MISHIMA Hiromu 三嶋弘

Researcher Number	20034100
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2005: 広島大学, 大学院・医歯薬総合研究科, 教授 2004 – 2005: 広島大学, 大学院・医歯薬学総合研究科, 教授 2002: Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 1996 – 2001: Hiroshima Univ.Sch.of Med.Professor, 医学部, 教授 1995: 広島大学, 医学部, 助教授 1988 – 1993: 広島大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Ophthalmology / Ophthalmology Except Principal Investigator Ophthalmology
Keywords	Principal Investigator 網膜神経節細胞 / グルタミン酸 / griseolic acid / cyclic AMP / Caspase-3 / Wnt14 / BDNF / 緑内障 / nitric oxide synthase / nitric oxide … More / 網膜 / 一酸化窒素合成酵素 / 一酸化窒素 / 神経保護 / PACAP / VIP / 神経細胞死 / 培養網膜 / 眼圧 / 毛様体上皮 / melanin / ocular penetration / aqueous humor dynamics / Morphological change / intraocular pressure / cAMP-phosphodiesterase inhibitor / 眼圧下降 / CAMP-poshodi esterase阻害剤 / 房水循環動態 / cAMP分解酵素阻害剤 / メラニン色素 / 眼内移行 / 房水質循環動態 / 形態学的変化 / CAMP分解酵素阻害剤 / グリセオ-ル酸 / neuroprotection / R28 cells / retina / chick embryo / protemiomcs / 3次元培養 / cell-sorting system / 組み合わせプロテオミクス解析 / マススペストロメトリー / 神経保護作用 / R28細胞 / 家鶏胚 / プロテオミクス解析 / PDGFR / プロテオミクス / 神経 / antibody / NMDA receptor / SAM mouse / retinal ganglion cell death / glaucoma / ODAG / 網膜分化 / グルタミン酸受容体 / NOS / 神経節細胞死 / 抗体 / NMDA受容体 / SAMマウス / 網膜神経節細胞死 / novel gene / cDNA microarray / glutamate receptor / intracellular Ca^<2+> concentration / glutamate neurotoxity / retinal ganglion / differential display / 新規遺伝子 / 発生 / 細胞内カルシウム濃度 / magnetic cell sorter / retinal ganglion cell / glutamate / 逆行性標識 / 細胞培養 / Thy-1 / 磁気細胞分離システム / Acidosis / Patch-clamp / Calcium ion / Glutamate / Neuronal death / Retinal culture / 血管作動性腸管ペプチド / プロテインキナーゼC / アシドーシス / パッチクランプ法 / カルシウムイオン / Intraocular pressure / Blood aqueous barrier / Ciliary epithelia / Cyclic AMP (_cAMP) / Inositol triphospholipid (IP_3) / Intra-cellular signaling system / Prostaglandins / イノシトール1,4,5・三燐酸(IP_3) / 血液眼房水柵 / サイクリックAMP(cAMP) / イノシトール1,4,5-三燐酸(IP_3) / 細胞内情報伝達系 / プロスタグランディン / Cultured ciliary epithelia (CE) / Cross-talk between cellular signalling systems / Inositol phospholipid turnover system / Protein kinase C (PKC) / Adenosine 3' : 5'-cyclic monophosphate (cAMP) / 眼圧調整機構 / イノシト-ル1、4、5ー三燐酸(IP3) / プロテインキナ-ゼC(PKC) / プロテインキナ-ゼ C / 培養毛様体上皮 / 情報伝達系のクロ-スト-ク / イノシト-ル燐脂質代謝回転系 / プロテインキナ-ゼC / cyclic AMP系 … More Except Principal Investigator RAD51B / homologous recombination / embryonal stem cell / knockout mouse / recombinational repair / Nervous system / 細胞周期 / ES細胞(胚性幹細胞) / Rad51B / 相同組み換え / 胚性幹細胞 / ノックアウトマウス / 遺伝子損傷修復 / 神経系 Less

Protein screening and analysis for the retina degenerationPrincipal Investigator
- Principal Investigator
  
  MISHIMA Hiromu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  HIROSHIMA UNIVERSITY
Molecular biological and molecular genetic studies in apoptosis of retinal ganglion cells and retinal differentiation.Principal Investigator
- Principal Investigator
  
  MISHIMA Hiromu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  HIROSHIMA UNIVERSITY
Research of RAD51B in the pathogenesis of ocular vascular occlusive disease
- Principal Investigator
  
  MINAMOTO Atsushi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  HIROSHIMA UNIVERSITY
Neuroprotection for Cell Death of Retinal Ganglion Cells and Molecular Biological Study for Nervi-RegenerationPrincipal Investigator
- Principal Investigator
  
  MISHIMA Hiromu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Hiroshima University
Neurophysiological study for excitatory amino acids-induced neurotoxicity and apoptosis in cultured retinal neurons.Principal Investigator
- Principal Investigator
  
  MISHIMA Hiromu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  HIROSHIMA UNIVERSITY
Neurophysiological examination in relationship of glaucomatous neurodegeneration and glutamate neurotoxicityPrincipal Investigator
- Principal Investigator
  
  MISHIMA Hiromu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  HIROSHIMA UNIVERSITY
Ocular hypotensive effect and intra-cellular signal transduction system of prostaglardins.Principal Investigator
- Principal Investigator
  
  MISHIMA Hiromu
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  HIROSHIMA UNIVERSITY
Roll of cellular Signalling systems on intraocular pressure regulation mechanisms.Principal Investigator
- Principal Investigator
  
  MISHIMA Hiromu
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Hiroshima University
Experimental Study on Changes of Intraocular Pressure by the Application of Griseolic AcidPrincipal Investigator
- Principal Investigator
  
  MISHIMA Hiromu
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  HIROSHIMA UNIVERSITY

All 2005

All Journal Article

[Journal Article] Neuroprotective effects of erythropoietin on glutamate and nitric oxide toxicity in primary cultured retinal ganglion cells.2005
- Author(s)
  Yamasaki M, Mishima HK, et al.
- Journal Title
  
  Brain Research 1050
  
  Pages: 15-26
- Data Source
  KAKENHI-PROJECT-16591756

1. MINAMOTO Atushi (10253072)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. KIUCHI Yoshiaki (40214738)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. FURUMOTO Atsuhito (80238691)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KOSAKA Toshiya (50253084)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OKADA Koji (80294578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 広田篤 (10243560)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. NIKAIDO Hirotoshi (80237651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KANAMOTO Takashi (20359889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHIMADA Sigeaki (30196480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKANO Kensuke (30164247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 鈴木雅信 (40206529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 永田淳士

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MISHIMA Hiromu 三嶋 弘

Research Projects

Research Products

Co-Researchers

Protein screening and analysis for the retina degenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular biological and molecular genetic studies in apoptosis of retinal ganglion cells and retinal differentiation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of RAD51B in the pathogenesis of ocular vascular occlusive disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neuroprotection for Cell Death of Retinal Ganglion Cells and Molecular Biological Study for Nervi-RegenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neurophysiological study for excitatory amino acids-induced neurotoxicity and apoptosis in cultured retinal neurons.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neurophysiological examination in relationship of glaucomatous neurodegeneration and glutamate neurotoxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ocular hypotensive effect and intra-cellular signal transduction system of prostaglardins.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roll of cellular Signalling systems on intraocular pressure regulation mechanisms.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental Study on Changes of Intraocular Pressure by the Application of Griseolic AcidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Neuroprotective effects of erythropoietin on glutamate and nitric oxide toxicity in primary cultured retinal ganglion cells.2005

Author(s)

Journal Title

Data Source

MISHIMA Hiromu 三嶋弘