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AOKI Takashi  青木 孝

ORCIDConnect your ORCID iD *help
Researcher Number 20053283
External Links
Affiliation (based on the past Project Information) *help 2009 – 2010: 順天堂大学, 医学部, 教授
1995 – 2007: 順天堂大学, 医学部, 教授
1992 – 1993: 順天堂大学, 医学部, 教授
1990: Juntendo Univ. Parasitol. Professor, 医学部, 教授
1989: 順天堂大学, 医学部, 助教授
1987: Juntendo University School of Medicine, 医学部・寄生虫学講座, 助教授
1986: 順天堂大, 医学部, 助教授
Review Section/Research Field
Principal Investigator
寄生虫学(含医用動物学) / 寄生虫学(含医用動物学) / Parasitology (including Sanitary zoology)
Except Principal Investigator
Chemical pharmacy / Sociology
Keywords
Principal Investigator
Trypanosoma / c-FLIP / トリパノソーマ / Acivicin / affinity labeling / Crithidia fasciculata / INHIBITION OF APOPTOSIS / TRYPANOSOMA CRUZI / アポトーシス抑制 / ピリミジンヌクレオチド … More / Trypanosoma cruzi / AZT / Allopurinol / Leishmania / Crithidia / glutamine antagonist / carbamoyl-phosphate synthetase II (EC 6.3.5.5) / pyrimidine nucleotides / parasitic protozoa (Trypanosomatidae) / グルタミン / 代謝調節 / カルバミルリン酸合成酵素(EC6.3.5.5) / 増殖阻害 / グルタミン拮抗剤 / acivicin / カルバミルリン酸合成酵素II(EC6.3.5.5) / トリパノソーマ科寄生原虫 / UPREGULATION OF PROLIFERATION INHIBITORS / TRANSCRIPTOME / PYRIMIDINE -BIOSYNTHETIC GENE CLUSTER / CHAGAS' DISEASE / UBIQUITINATION OF cFLIP / INFECTED HUMAN CELLS / 海草抽出物 / 塩基置換頻度(SNPs) / 原虫の生残り / cDNAチップ / cFLIPのユビキチン化 / 増殖抑制因子のupregulation / 増殖促進因子のdownregulation / リアルタイムPCR / 増殖促進遺伝子のdownregulation / 増殖抑制遺伝子のuregulation / マイクロアレイ / 遺伝子の起原と分子進化 / ピリミジン合成遺伝子 / 翻訳後プロセッシング / ACT-DHOD融合遺伝子 / 増殖抑制遺伝子のupregulation / トランスクリプトーム / ピリミジン合成遺伝子クラスター / Chagas病 / cFLIP のユビキチン化 / 感染ヒト細胞 / PHAGE DISPLAY / PROTEIN-PROTEIN INTERACTION BETWEEN T CRUZI AND HOST CELLS / PYRIMIDINE BIOSYNTHESIS / FAS-MEDIATED SIGNALING PATHWAY / 原虫-宿主たんぱく質相互作用 / ピリミジン生合成第1酵素 / DNAマイクロアレイ / c FLIP / ファージデイスプレイ / ファージディスプレイ / 原虫-宿主タンパク質相互作用 / ピリミジン生合成酵素 / Fasシグナル伝達系 / Evolution of a metabolic pathway / Enzyme assays for recombinant pyr sene products / pyr genes knockout by homologous recombination / Over-expression of pyr gene products / Pyrimidine-biosynthetic (pyr) gene cluster / Pyrimidine nucleotide biosynthesis / 多機能タンパク質 / リーシュマニア / 遺伝子クラスター / pyr遺伝子群 / RNAi / 過剰発現 / 遺伝子共発現 / pyr遺伝子 / 新生合成経路 / 代謝経路の進化 / 海藻抽出液 / 組換え酵素活性 / 遺伝子過剰発現 / 遺伝子ノックアウト / pyr遺伝子クラスター / ピリミジンヌクレオチド生合成経路 / natural plant drugs / synthetic peptides / Calcium antagonist / drug-screening system / Changas' disease / anti-trypanosomal drugs / 抗エイズ薬 / アロプリノール / イノシン誘導体 / アジア原産生薬 / 抗菌ペプチド / カルシウム拮抗剤 / 薬剤スクリーニング法 / シャーガス病 / クルーズトリパノソーマ / 抗トリパノソーマ薬 / gene mapping / pulsed field gel electrophoresis / single copy gene / spliced leader (SL) / ACT / CPS II / pyrimidine synthesis / スプライストリーダー(SL) / アスパラギン酸トランスカルバモイラーゼ / スプライスリーダー(SL) / 遺伝子マッピング / パルスフィールド・ゲル電気泳動 / 単一コピー遺伝子 / スプライス リーダー(SL) / アスパラギン酸カルバモイルトランスフェラーゼ / カルバモイルーリン酸合成酵素 / ピリミジン合成 / Cellular fractionation / Localization / Gene cloning / Carbamoyl-phosphate synthetase II / Orotate phosphoribo-syltransferase / Pyrimidine biosynthesis / Glycosome / OMPデカルボキシラーゼ / オロト酸ホスホリボシルトランスフェラーセ / 細胞分画 / 細胞内局在性 / 遺伝子クローニング / カルバモイルリン酸合成酵素 / オロト酸ホスホリボシルトランスフェラーゼ / ピリミジン塩基生合成 / glycosome / Inhibition of cell growth / Chemotherapy / Nucleic acid precursors / Trypanosomatids / 化学療法 / 細胞増殖阻害 / 核酸前駆体 / トリパノソ-マ科原虫 … More
Except Principal Investigator
Trypanosoma cruzi / sesquiterpene lactone / 生化学 / 抗マラリア剤 / 呼吸鎖 / ミトコンドリア / ネズミマラリア原虫 / hydroperoxide / Chenopodium ambrosioides / terpenoid / trypanosomiasis / monoterpene / dasymachaline-N-oxide / Desmos dasymachalus / Laurus nobilis / Alpinia galanga / トリパノソーマ / HeLa cell / Michelea alba / epimastigote / terpineol / limonene / β-resorcylic acid ester / HeLa細胞 / Michelia alba / natural medicines / Hela infection assay / ローレル / 天然薬物 / dasymacharine-N-oxide / 1′-acetoxychavicol acetate / Vietnam / natural medicine / HeLa infection assay / 政策への信頼・協力 / リスク評価 / 教育的介入 / リスク回避 / リスク認知 Less
  • Research Projects

    (14 results)
  • Research Products

    (56 results)
  • Co-Researchers

    (12 People)
  •  新型インフルエンザ; リスク認知とリスク回避行動の関係についての実証的研究

    • Principal Investigator
      TSUBOUCHI AKIKO
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Sociology
    • Research Institution
      Juntendo University
  •  TRYPANASOMAGRUZI : MOLECULAR BASES FOR INTRACELLULAR PARASITISM, PROLIFERATION, AND PATHOGENICITY IN INFECTED HUMAN CELLSPrincipal Investigator

    • Principal Investigator
      AOKI Takashi
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Parasitology (including Sanitary zoology)
    • Research Institution
      Juntendo University
  •  MOLECULAR STRATEGIES OF TRYPANOSOMA CRUZI IN REMODELING AND CONTROLLING THE INFECTED HOST CELLSPrincipal Investigator

    • Principal Investigator
      AOKI Takashi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Parasitology (including Sanitary zoology)
    • Research Institution
      JUNTENDO UNIVERSITY
  •  Molecular characterization of all the six enzymes and their corresponding genes involved in de novo pyrimidine biosynthesis in trypanosomatidsPrincipal Investigator

    • Principal Investigator
      AOKI Takashi
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      寄生虫学(含医用動物学)
    • Research Institution
      Juntendo University
  •  Development of Anti-trypanosomal Drugs Based on Terpene Structure as an Active Unit

    • Principal Investigator
      KIUCHI Fumiyuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      KYOTO UNIVERSITY
  •  ネズミマラリア原虫ミトコンドリア呼吸鎖成分の生化学解析

    • Principal Investigator
      高宮 信三郎
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Juntendo University
  •  A Search for Naturally Occurring Anti-trypanosomal Compounds Using a HeLa Cell Infection Assay System

    • Principal Investigator
      KIUCHI Fumiyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      KYOTO UNIVERSITY
  •  ネズミマラリア原虫ミトコンドリア呼吸鎖成分の生化学的解析

    • Principal Investigator
      高宮 信三郎
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Juntendo University
  •  ネズミマラリア原虫ミトコンドリア呼吸鎖成分の生化学的解析

    • Principal Investigator
      TAKAMIYA Shinzaburo
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Juntendo University
  •  Molecular characterization of CPS II and ACT genes form Trypanosoma cruziPrincipal Investigator

    • Principal Investigator
      AOKI Takashi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      寄生虫学(含医用動物学)
    • Research Institution
      Juntendo University
  •  Establishment of an in vitro screening system for anti-Trypanosoma cruzi agentsPrincipal Investigator

    • Principal Investigator
      AOKI Takashi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      寄生虫学(含医用動物学)
    • Research Institution
      Juntendo University
  •  Molecular and biochemical studies on the enzymes of nucleic acid precursor synthesis unique to trypanosomatid parasitesPrincipal Investigator

    • Principal Investigator
      AOKI Takashi
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      寄生虫学(含医用動物学)
    • Research Institution
      Juntendo University School of Medicine
  •  Biosynthesis of Nucleic Acid Precursors and Its Inhibition in Trypanosomatid ParasitesPrincipal Investigator

    • Principal Investigator
      AOKI Takashi
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      寄生虫学(含医用動物学)
    • Research Institution
      Juntendo University School of Medicine
  •  Comparative studies on pyrimidine nucleotide biosynthesis characteristic of parasitic protozoaPrincipal Investigator

    • Principal Investigator
      AOKI Takashi
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      寄生虫学(含医用動物学)
    • Research Institution
      Juntendo University School of Medicine

All 2010 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

  • [Book] ハリソン内科学(原著第16版), Part 6感染症, Section 17〜19(第192〜204章)(監訳)福井次矢・黒川清(日本語版監修)2006

    • Author(s)
      青木 孝
    • Total Pages
      83
    • Publisher
      メディカル・サイエンス・インターナショナル,東京
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Book] ハリソン内科学(原著第16版)、Part 6 感染症、Section 17-19(第192-204章)(監訳) 福井次矢, 黒川清(日本語版監修)2006

    • Author(s)
      青木孝
    • Total Pages
      83
    • Publisher
      メディカル・サイエンス・インターナショナル、東京
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Book] Metabolism of parasitic protozoa. In Progress of Medical Parasitology in Japan, Vol.7 (edited by M Otsuru et al.) Chapter III.2003

    • Author(s)
      Aoki T
    • Publisher
      Megro Parasitological Museum, Tokyo
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Evolutionary analysis of synteny and gene fusion for pyrimidine biosyntheticenzymes in Euglenozoa:the gap between kinetoplastids and diplonemids2008

    • Author(s)
      Makiuchi T, Annoura T, Hashimoto T, Murata E, Aoki T, Nara T
    • Journal Title

      Protist (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Evolutionary analysis of synteny and gene fusion for pyrimidine biosynthetic enzymes in Euglenozoa : an extraordinary gap between kinetoplastids and diplonemids2008

    • Author(s)
      Makiuchi, T., Annoura, T., Hashimoto, T., Murata, E., Aoki, T., Nara, T
    • Journal Title

      Protist (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Evolutionary analysis of synteny and gene fusion for pyrimidine biosynthetic enzymes in Euglenozoa:the gap between kinetoplastids and diplonemids2008

    • Author(s)
      Makiuchi T, Annoura T, Hashimoto T, Murata E, Aoki T, Nara T
    • Journal Title

      Protist (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Transcriptome profile of Trypanosoma cruzrinfected cells : simultaneous up- and down-regulation of proliferation inhibitors and promoters2008

    • Author(s)
      Shigihara, T., Hashimoto, M., Shindo, N., Aoki, T
    • Journal Title

      Parasitol Res (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Transcriptome profile of Trypanosoma cruzi-infected cells:simultaneous up-and down-regulation of proliferation inhibitors and promoters2008

    • Author(s)
      Shigihara T, Hashimoto M, Shindo N, Aoki T
    • Journal Title

      Parasitology Research (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Dihydroorotate dehydrogenase arises from novel fused gene product with aspartate carbamoyltransferase in Bodo saliens2007

    • Author(s)
      Annoura T, Sariego I, Nara T, Makiuchi T, Fujimura T, Taka H, Mineki R, Murayama K, Aoki T
    • Journal Title

      Biochemical and Biophysical Research Communications 358

      Pages: 253-258

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Occurrence of multiple,independent gene fusion events for the fifth and sixth enzymes of pyrimidine biosynthesis in different eukaryotic groups2007

    • Author(s)
      Makiuchi T, Nara T, Annoura T, Hashimoto T, Aoki T
    • Journal Title

      Gene 394

      Pages: 78-86

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Dihydroorotate dehydrogenase arises from novel fused gene product with aspartate carbamoyl-transferase in Bodo saliens2007

    • Author(s)
      Annoura, T., Sariego, I., Nara, T., Makiuchi, T., Fujimura, T., Taka, H., Mineki, R, Murayama, K., Aoki, T
    • Journal Title

      Biochem Biophys Res Comm un 358

      Pages: 253-258

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Dihydroorotate dehydrogenase arises from novel fused gene product with aspartate carbamoyltransferase in Bodo saliensfus2007

    • Author(s)
      Annoura T, Sariego I, Nara T, Makiuchi T, Fujimura T, Taka H, Mineki R, Murayama K, Aoki T
    • Journal Title

      Biochemical and Biophysical ResearchCommunications 358

      Pages: 253-258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Antibody isotype responses to paramyosin, a vaccine candidate for schistosomiasis, and their correlations with resistance and fibrosis in patients infected with Schistosomiasis japonicum in Leyte, The Philippines2007

    • Author(s)
      Nara T, Iizumi K, Ohmae H, Sy OS, Tsubota S, Inaba Y, Tsubouchi A, Tanabe M, Kojima S, Aoki T
    • Journal Title

      American Journal of Tropical Medicine and Hygiene 76

      Pages: 384-391

    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Occurrence of multiple, independent gene fusion events for the fifth and sixth enzymes of pyrimidine biosynthesis in different eukaryotic groups2007

    • Author(s)
      Makiuchi, T., Nara, T., Annoura, T., Hashimoto, T., Aoki, T
    • Journal Title

      Gene 394

      Pages: 78-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms2006

    • Author(s)
      Sariego I, Annoura T, Nara T, Hashimoto M, Tsubouchi A, Iizumi K, Makiuchi T, Murata E, Kita K, Aoki T
    • Journal Title

      Parasitology International 55

      Pages: 11-16

    • NAID

      10017321391

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Molecular cloning and characterization of ouabain-insensitive Na+-ATPase in the parasitic protist, Trypanosoma cruzi2006

    • Author(s)
      Iizumi, K., Mikami, Y., Hashimoto, M., Nara, T., Hara, Y., Aoki
    • Journal Title

      Biochim BiophysActa Biomembranes 1758

      Pages: 738-746

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Molecular cloning and characterization of ouabain-insensitive Na^+-ATPase in the parasitic protist, Trypanosoma cruzi2006

    • Author(s)
      Iizumi K, Mikami Y, Hashimoto M, Nara T, Hara Y, Aoki T
    • Journal Title

      Biochimica et Biophysica Acta-Biomembranres 1758

      Pages: 738-746

    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Molecular cloning and characterization of ouabain-insensitive Na^+-ATPase in the parasitic protist,Trypanosoma cruzi2006

    • Author(s)
      Iizumi K, Mikami Y, Hashimoto M, Nara T, Hara Y, Aoki T
    • Journal Title

      Biochimica et Biophysica Acta-Biomembranres 1758

      Pages: 738-746

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms2006

    • Author(s)
      Sariego, I., Annoura, T., Nara, T., Hashimoto, M., Tsubouchi, A., Iizumi, K., Makiuchi, T., Murata, E., Kita, K., Aoki, T
    • Journal Title

      Parasitollnt 55

      Pages: 11-16

    • NAID

      10017321391

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme2005

    • Author(s)
      Uchiyama N, Kabututu Z, Kubata BK, Kiuchi F, Ito M, Nakajima-Shimada J, Aoki T, Ohkubo K, Fukuzumi S, Martin SK, Honda G, Urade Y
    • Journal Title

      Antimicrobial Agents and Chemotherapy 49

      Pages: 5123-5126

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate2005

    • Author(s)
      Inaoka, DK., Takashima, E., Osanai, A., Shimizu, H., Nara, T., Aoki, T., Harada, S., Kita, K
    • Journal Title

      Acta Cryst F61

      Pages: 875-878

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Expression,purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate2005

    • Author(s)
      Inaoka DK, Takashima E, Osanai A, Shimizu H, Nara T, Aoki T, Harada S, Kita K
    • Journal Title

      Acta Crystallographica F61

      Pages: 875-878

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Gene expression profiles in response to Fas stimulation in Trypanosoma cruzi-infected host cells2005

    • Author(s)
      Hashimoto M, Nakajima-Shimada J, Ishidoh K, Aoki T
    • Journal Title

      International Journal for Parasitology 35

      Pages: 1587-1594

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions2005

    • Author(s)
      Annoura, T., Nara, T., Makiuchi, T., Hashimoto, T., Aoki, T
    • Journal Title

      JMol Evol 60

      Pages: 113-127

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydro-genase activity and on the protozoan growth in mammalian cells.2005

    • Author(s)
      Nara T, Kamei Y, Tsubouchi A, Annoura T, Hirota K, Iizumi K, Dohmoto Y, Ono T, Aoki T
    • Journal Title

      Parasitol Int 54

      Pages: 59-64

    • NAID

      10015455204

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells2005

    • Author(s)
      Nara T, Kamei Y, Tsubouchi A, Annoura T, Hirota K, Iizumi K, Dohmoto Y, Ono T, Aoki T
    • Journal Title

      Parasitology International 54

      Pages: 59-64

    • NAID

      10015455204

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids,with special reference to their biological significance and adaptation to anaerobic,parasitic conditions2005

    • Author(s)
      Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T
    • Journal Title

      Journal of Molecular Evolution 60

      Pages: 113-127

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Trypanosoma cruzi post-transcriptionally upregulates and exploits cellular FLIP for inhibition of death-inducing signal2005

    • Author(s)
      Hashimoto, M., N.-Shimada, J., Aoki, T
    • Journal Title

      Mol Biol Cell 16

      Pages: 3521-3528

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Gene Expression profiles in response to Fas stimulation in Trypanosoma cruzrinfected host cells2005

    • Author(s)
      Hashimoto, M., Nakajima-Shimada, J., Ishidoh, K., Aoki, T
    • Journal Title

      Int J Parasitol 35

      Pages: 1587-1594

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells2005

    • Author(s)
      Nara T, Kamei Y, Tsubouchi A, Annoura T, Hirota K, Iizumi K, Dohmoto Y, Ono T, Aoki T
    • Journal Title

      Parasitology International 54

      Pages: 59-64

    • NAID

      10015455204

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions.2005

    • Author(s)
      Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T
    • Journal Title

      J Mol Evol 60

      Pages: 113-127

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Trypanosoma cruzi posttranscriptionally up-regulates and exploits cellular FLIP for inhibition of death-inducing signal2005

    • Author(s)
      Hashimoto M, N.-Shimada J, Aoki T
    • Journal Title

      Molecular Biology of the Cell 16

      Pages: 3521-3528

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Trypanosoma cruzi post-transcriptionally upregulates cellular FLIP for inhibition of death-inducing signal2005

    • Author(s)
      Hashimoto M, N.-Shimada J, Aoki T
    • Journal Title

      Molecular Biology of the Cell (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Trypanosome cruzi posttranscriptionally up-regulates and exploits cellular FLIP for inhibition of death-inducing signal2005

    • Author(s)
      Hashimoto M, N.-Shimada J, Aoki T
    • Journal Title

      Molecular Biology of the Cell 16

      Pages: 3521-3528

    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions2005

    • Author(s)
      Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T
    • Journal Title

      Journal of Molecular Evolution 60

      Pages: 113-127

    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase and on the protozoan growth in mammalian cells2005

    • Author(s)
      Nara T, Kamei Y, Tsubouchi A, Annoura T, Hirota K, Iizumi K, Dohmoto Y, Ono T, Aoki T
    • Journal Title

      Parasitology International 54

      Pages: 59-64

    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme2005

    • Author(s)
      Uchiyama, N., Kabututu, Z., Kubata, BK., Kiuchi, F., Ito, M., Nakajima-Shimada, J., Aoki, T., Ohkubo, K., Fukuzumi, S., Martin, SK., Honda, G., Urade, Y
    • Journal Title

      Antimicrob Agents Chemother 49

      Pages: 5123-5126

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate2005

    • Author(s)
      Inaoka DK, Takashima E, Osanai A, Shimizu H, Nara T, Aoki T, Harada S, Kita K
    • Journal Title

      Acta Crystallographica F61

      Pages: 875-878

    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions2005

    • Author(s)
      Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T
    • Journal Title

      Journal of Molecular Evolution 50

      Pages: 112-127

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions2005

    • Author(s)
      Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T
    • Journal Title

      Journal of Molecular Evolution 60

      Pages: 113-127

    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells2005

    • Author(s)
      Nara, T., Kamei, Y., Tsubouchi, A., Annoura, T., Hirota, K., Iizumi, K., Dohmoto, Y, Ono, T., Aoki, T
    • Journal Title

      Parasitollnt 54

      Pages: 59-64

    • NAID

      10015455204

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390123
  • [Journal Article] Trypanosoma cruzi抗原と作用するヒト心筋細胞タンパク質のファージディスプレイ法による解析2004

    • Author(s)
      吉田彩子, 奈良武司, 青木孝
    • Journal Title

      第73回日本寄生虫学会大会プログラム・抄録集

      Pages: 60-60

    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Inhibition of Trypanosome cruzi growth in mammalian cells by nimodipine, with low cytotoxicity to host cells2004

    • Author(s)
      Hirota K, Tsubouchi A, N.-Shimada J, Nara T, Aoki T
    • Journal Title

      Tropical Medicine and Health 32

      Pages: 181-188

    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Inhibition of Trypanosoma cruzi growth in mammalian cells by nimodipine, with low cytotoxicity to host cells2004

    • Author(s)
      Hirota K, Tsubouchi A, N.-Shinada J, Nara T, Aoki T
    • Journal Title

      Tropical Medicine and Health 32

      Pages: 181-188

    • NAID

      10013297272

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Inhibition of Trypanosoma cruzi growth in mammalian cells by nimodipine, with low cytotoxicity to host cells.2004

    • Author(s)
      Hirota K, Tsubouchi A, N.-Shimada J, Nara T, Aoki T
    • Journal Title

      Trop Med Health 32

      Pages: 181-188

    • NAID

      10013297272

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Trypanosoma cruzi抗原と作用するヒト心筋細胞タンパク質のファージデイスプレイ法による解析2004

    • Author(s)
      吉田彩子, 奈良武司, 青木孝
    • Journal Title

      第73回日本寄生虫学会大会プログラム・抄録集

      Pages: 60-60

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Trypanocidal constituents from Michelia alba.2003

    • Author(s)
      Asaruddin MR, Honda G, Tsubouchi A, Nakajima-Shimada J, Aoki T, Kiuchi F
    • Journal Title

      Natural Medicines 57

      Pages: 61-63

    • NAID

      50000804055

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection.2003

    • Author(s)
      Miyahira Y, Katae M, Kobayashi S, Takeuchi T, Fukuchi Y, Abe R, Okumura K, Yagita H, Aoki T
    • Journal Title

      Infect Immun 71

      Pages: 3131-3137

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Metabolism parasitic protozoa2003

    • Author(s)
      Aoki T
    • Journal Title

      Progress of Medical Parasitology in Japan (edited by M Otsuru et al.)(Megro Parasitological Museum, Tokyo) Vol.7,Chapter III

      Pages: 175-191

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection2003

    • Author(s)
      Miyahira Y, Katae M, Kobayashi S, Takeuchi T, Fukuchi Y, Abe R, Okumura K, Yagita H, Aoki T
    • Journal Title

      Infect Immun 71

      Pages: 3131-3137

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Trypanocidal constituents from Michelia alba2003

    • Author(s)
      Asaruddin MR.Honda G, Tsubouchi A, N.-Shinada J, Aoki T, Kiuchi F
    • Journal Title

      Natural Medicines 57

      Pages: 61-63

    • NAID

      50000804055

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Diversity of aspartate carbamoyltransferase genes of Trypanosoma cruzi2003

    • Author(s)
      Nara T, Hirayama-Noguchi Y, Gao G, Murai E, Annoura T, Aoki T
    • Journal Title

      Int J Parasitol 33

      Pages: 845-852

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Diversity of aspartate carbamoyltransferase genes of Trypanosoma cruzi.2003

    • Author(s)
      Nara T, Hirayama-Noguchi Y, Gao G, Murai E, Annoura T, Aoki T
    • Journal Title

      Int J Parasitol 33

      Pages: 845-852

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Trypanosoma cruzi post-transcriptionally upregulates cellular FLIP for inhibition of death-inducing signal.

    • Author(s)
      Hashimoto M, N.-Shimada J, Aoki T
    • Journal Title

      Mol Biol Cell (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390138
  • [Journal Article] Occurrence of multiple, independent gene fusion events for the fifth and sixth enzymes of pyrimidine biosynthesis in different eukaryotic groups

    • Author(s)
      Makiuchi T, Nara T, Annoura T, Hashimoto T, Aoki T
    • Journal Title

      Gene (in press)

    • Data Source
      KAKENHI-PROJECT-17390123
  • [Presentation] Evolutionary analysis of synteny and gene fusion for pyrimidine biosynthetic enzymes in Euglenozoa : An extraordinary gap between kinetoplastids and diplonemids2010

    • Author(s)
      Makiuchi T, Annoura T, Hashimoto T, Aoki T, Nara T
    • Organizer
      XIIth International Congress of Parasitology (ICOPA)
    • Place of Presentation
      Melbourne, Australia
    • Data Source
      KAKENHI-PROJECT-21653043
  • 1.  SHIMADA Junko (20211964)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 5 results
  • 2.  TAKAMIYA Shinzaburo (90138206)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  NARA Takeshi (40276473)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 37 results
  • 4.  SHIMOGAWARA Rieko (50146776)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  TSUBOUCHI AKIKO (10398662)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 6.  KIUCHI Fumiyuki (60161402)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  YAMASAKI Hiroshi (00138207)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  YOSHIDA Ayako (20343486)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 9.  HASHIMOTO Muneaki (30407308)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 21 results
  • 10.  ANNOURA TAKESHI (90407239)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 16 results
  • 11.  KITA Kiyoshi (90134444)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  丸井 英二 (30111545)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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