AOKI Takashi 青木孝

Researcher Number	20053283
External Links
Affiliation (based on the past Project Information) *help	2009 – 2010: 順天堂大学, 医学部, 教授 1995 – 2007: 順天堂大学, 医学部, 教授 1992 – 1993: 順天堂大学, 医学部, 教授 1990: Juntendo Univ. Parasitol. Professor, 医学部, 教授 1989: 順天堂大学, 医学部, 助教授 1987: Juntendo University School of Medicine, 医学部・寄生虫学講座, 助教授 1986: 順天堂大, 医学部, 助教授
Review Section/Research Field	Principal Investigator 寄生虫学(含医用動物学) / 寄生虫学(含医用動物学） / Parasitology (including Sanitary zoology) Except Principal Investigator Chemical pharmacy / Sociology
Keywords	Principal Investigator Trypanosoma / c-FLIP / トリパノソーマ / Acivicin / affinity labeling / Crithidia fasciculata / INHIBITION OF APOPTOSIS / TRYPANOSOMA CRUZI / アポトーシス抑制 / ピリミジンヌクレオチド … More / Trypanosoma cruzi / AZT / Allopurinol / Leishmania / Crithidia / glutamine antagonist / carbamoyl-phosphate synthetase II (EC 6.3.5.5) / pyrimidine nucleotides / parasitic protozoa (Trypanosomatidae) / グルタミン / 代謝調節 / カルバミルリン酸合成酵素(EC6.3.5.5) / 増殖阻害 / グルタミン拮抗剤 / acivicin / カルバミルリン酸合成酵素II(EC6.3.5.5) / トリパノソーマ科寄生原虫 / UPREGULATION OF PROLIFERATION INHIBITORS / TRANSCRIPTOME / PYRIMIDINE -BIOSYNTHETIC GENE CLUSTER / CHAGAS' DISEASE / UBIQUITINATION OF cFLIP / INFECTED HUMAN CELLS / 海草抽出物 / 塩基置換頻度(SNPs) / 原虫の生残り / cDNAチップ / cFLIPのユビキチン化 / 増殖抑制因子のupregulation / 増殖促進因子のdownregulation / リアルタイムPCR / 増殖促進遺伝子のdownregulation / 増殖抑制遺伝子のuregulation / マイクロアレイ / 遺伝子の起原と分子進化 / ピリミジン合成遺伝子 / 翻訳後プロセッシング / ACT-DHOD融合遺伝子 / 増殖抑制遺伝子のupregulation / トランスクリプトーム / ピリミジン合成遺伝子クラスター / Chagas病 / cFLIP のユビキチン化 / 感染ヒト細胞 / PHAGE DISPLAY / PROTEIN-PROTEIN INTERACTION BETWEEN T CRUZI AND HOST CELLS / PYRIMIDINE BIOSYNTHESIS / FAS-MEDIATED SIGNALING PATHWAY / 原虫-宿主たんぱく質相互作用 / ピリミジン生合成第1酵素 / DNAマイクロアレイ / c FLIP / ファージデイスプレイ / ファージディスプレイ / 原虫-宿主タンパク質相互作用 / ピリミジン生合成酵素 / Fasシグナル伝達系 / Evolution of a metabolic pathway / Enzyme assays for recombinant pyr sene products / pyr genes knockout by homologous recombination / Over-expression of pyr gene products / Pyrimidine-biosynthetic (pyr) gene cluster / Pyrimidine nucleotide biosynthesis / 多機能タンパク質 / リーシュマニア / 遺伝子クラスター / pyr遺伝子群 / RNAi / 過剰発現 / 遺伝子共発現 / pyr遺伝子 / 新生合成経路 / 代謝経路の進化 / 海藻抽出液 / 組換え酵素活性 / 遺伝子過剰発現 / 遺伝子ノックアウト / pyr遺伝子クラスター / ピリミジンヌクレオチド生合成経路 / natural plant drugs / synthetic peptides / Calcium antagonist / drug-screening system / Changas' disease / anti-trypanosomal drugs / 抗エイズ薬 / アロプリノール / イノシン誘導体 / アジア原産生薬 / 抗菌ペプチド / カルシウム拮抗剤 / 薬剤スクリーニング法 / シャーガス病 / クルーズトリパノソーマ / 抗トリパノソーマ薬 / gene mapping / pulsed field gel electrophoresis / single copy gene / spliced leader (SL) / ACT / CPS II / pyrimidine synthesis / スプライストリーダー(SL) / アスパラギン酸トランスカルバモイラーゼ / スプライスリーダー(SL) / 遺伝子マッピング / パルスフィールド・ゲル電気泳動 / 単一コピー遺伝子 / スプライスリーダー(SL) / アスパラギン酸カルバモイルトランスフェラーゼ / カルバモイルーリン酸合成酵素 / ピリミジン合成 / Cellular fractionation / Localization / Gene cloning / Carbamoyl-phosphate synthetase II / Orotate phosphoribo-syltransferase / Pyrimidine biosynthesis / Glycosome / OMPデカルボキシラーゼ / オロト酸ホスホリボシルトランスフェラーセ / 細胞分画 / 細胞内局在性 / 遺伝子クローニング / カルバモイルリン酸合成酵素 / オロト酸ホスホリボシルトランスフェラーゼ / ピリミジン塩基生合成 / glycosome / Inhibition of cell growth / Chemotherapy / Nucleic acid precursors / Trypanosomatids / 化学療法 / 細胞増殖阻害 / 核酸前駆体 / トリパノソ-マ科原虫 … More Except Principal Investigator Trypanosoma cruzi / sesquiterpene lactone / 生化学 / 抗マラリア剤 / 呼吸鎖 / ミトコンドリア / ネズミマラリア原虫 / hydroperoxide / Chenopodium ambrosioides / terpenoid / trypanosomiasis / monoterpene / dasymachaline-N-oxide / Desmos dasymachalus / Laurus nobilis / Alpinia galanga / トリパノソーマ / HeLa cell / Michelea alba / epimastigote / terpineol / limonene / β-resorcylic acid ester / HeLa細胞 / Michelia alba / natural medicines / Hela infection assay / ローレル / 天然薬物 / dasymacharine-N-oxide / 1′-acetoxychavicol acetate / Vietnam / natural medicine / HeLa infection assay / 政策への信頼・協力 / リスク評価 / 教育的介入 / リスク回避 / リスク認知 Less

新型インフルエンザ; リスク認知とリスク回避行動の関係についての実証的研究
- Principal Investigator
  
  TSUBOUCHI AKIKO
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Sociology
- Research Institution
  Juntendo University
TRYPANASOMAGRUZI : MOLECULAR BASES FOR INTRACELLULAR PARASITISM, PROLIFERATION, AND PATHOGENICITY IN INFECTED HUMAN CELLSPrincipal Investigator
- Principal Investigator
  
  AOKI Takashi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Juntendo University
MOLECULAR STRATEGIES OF TRYPANOSOMA CRUZI IN REMODELING AND CONTROLLING THE INFECTED HOST CELLSPrincipal Investigator
- Principal Investigator
  
  AOKI Takashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  JUNTENDO UNIVERSITY
Molecular characterization of all the six enzymes and their corresponding genes involved in de novo pyrimidine biosynthesis in trypanosomatidsPrincipal Investigator
- Principal Investigator
  
  AOKI Takashi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  Juntendo University
Development of Anti-trypanosomal Drugs Based on Terpene Structure as an Active Unit
- Principal Investigator
  
  KIUCHI Fumiyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
ネズミマラリア原虫ミトコンドリア呼吸鎖成分の生化学解析
- Principal Investigator
  
  高宮信三郎
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Juntendo University
A Search for Naturally Occurring Anti-trypanosomal Compounds Using a HeLa Cell Infection Assay System
- Principal Investigator
  
  KIUCHI Fumiyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
ネズミマラリア原虫ミトコンドリア呼吸鎖成分の生化学的解析
- Principal Investigator
  
  高宮信三郎
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Juntendo University
ネズミマラリア原虫ミトコンドリア呼吸鎖成分の生化学的解析
- Principal Investigator
  
  TAKAMIYA Shinzaburo
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Juntendo University
Molecular characterization of CPS II and ACT genes form Trypanosoma cruziPrincipal Investigator
- Principal Investigator
  
  AOKI Takashi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  Juntendo University
Establishment of an in vitro screening system for anti-Trypanosoma cruzi agentsPrincipal Investigator
- Principal Investigator
  
  AOKI Takashi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  Juntendo University
Molecular and biochemical studies on the enzymes of nucleic acid precursor synthesis unique to trypanosomatid parasitesPrincipal Investigator
- Principal Investigator
  
  AOKI Takashi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  寄生虫学(含医用動物学）
- Research Institution
  Juntendo University School of Medicine
Biosynthesis of Nucleic Acid Precursors and Its Inhibition in Trypanosomatid ParasitesPrincipal Investigator
- Principal Investigator
  
  AOKI Takashi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  寄生虫学(含医用動物学）
- Research Institution
  Juntendo University School of Medicine
Comparative studies on pyrimidine nucleotide biosynthesis characteristic of parasitic protozoaPrincipal Investigator
- Principal Investigator
  
  AOKI Takashi
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  寄生虫学(含医用動物学）
- Research Institution
  Juntendo University School of Medicine

All 2010 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] ハリソン内科学(原著第16版), Part 6感染症, Section 17〜19(第192〜204章)(監訳)福井次矢・黒川清(日本語版監修)2006
- Author(s)
  青木孝
- Total Pages
  83
- Publisher
  メディカル・サイエンス・インターナショナル,東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Book] ハリソン内科学(原著第16版)、Part 6 感染症、Section 17-19(第192-204章)(監訳) 福井次矢, 黒川清(日本語版監修)2006
- Author(s)
  青木孝
- Total Pages
  83
- Publisher
  メディカル・サイエンス・インターナショナル、東京
- Data Source
  KAKENHI-PROJECT-17390123
[Book] Metabolism of parasitic protozoa. In Progress of Medical Parasitology in Japan, Vol.7 (edited by M Otsuru et al.) Chapter III.2003
- Author(s)
  Aoki T
- Publisher
  Megro Parasitological Museum, Tokyo
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Evolutionary analysis of synteny and gene fusion for pyrimidine biosyntheticenzymes in Euglenozoa:the gap between kinetoplastids and diplonemids2008
- Author(s)
  Makiuchi T, Annoura T, Hashimoto T, Murata E, Aoki T, Nara T
- Journal Title
  
  Protist (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Evolutionary analysis of synteny and gene fusion for pyrimidine biosynthetic enzymes in Euglenozoa : an extraordinary gap between kinetoplastids and diplonemids2008
- Author(s)
  Makiuchi, T., Annoura, T., Hashimoto, T., Murata, E., Aoki, T., Nara, T
- Journal Title
  
  Protist (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Evolutionary analysis of synteny and gene fusion for pyrimidine biosynthetic enzymes in Euglenozoa:the gap between kinetoplastids and diplonemids2008
- Author(s)
  Makiuchi T, Annoura T, Hashimoto T, Murata E, Aoki T, Nara T
- Journal Title
  
  Protist (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Transcriptome profile of Trypanosoma cruzrinfected cells : simultaneous up- and down-regulation of proliferation inhibitors and promoters2008
- Author(s)
  Shigihara, T., Hashimoto, M., Shindo, N., Aoki, T
- Journal Title
  
  Parasitol Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Transcriptome profile of Trypanosoma cruzi-infected cells:simultaneous up-and down-regulation of proliferation inhibitors and promoters2008
- Author(s)
  Shigihara T, Hashimoto M, Shindo N, Aoki T
- Journal Title
  
  Parasitology Research (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Dihydroorotate dehydrogenase arises from novel fused gene product with aspartate carbamoyltransferase in Bodo saliens2007
- Author(s)
  Annoura T, Sariego I, Nara T, Makiuchi T, Fujimura T, Taka H, Mineki R, Murayama K, Aoki T
- Journal Title
  
  Biochemical and Biophysical Research Communications 358
  
  Pages: 253-258
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Occurrence of multiple,independent gene fusion events for the fifth and sixth enzymes of pyrimidine biosynthesis in different eukaryotic groups2007
- Author(s)
  Makiuchi T, Nara T, Annoura T, Hashimoto T, Aoki T
- Journal Title
  
  Gene 394
  
  Pages: 78-86
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Dihydroorotate dehydrogenase arises from novel fused gene product with aspartate carbamoyl-transferase in Bodo saliens2007
- Author(s)
  Annoura, T., Sariego, I., Nara, T., Makiuchi, T., Fujimura, T., Taka, H., Mineki, R, Murayama, K., Aoki, T
- Journal Title
  
  Biochem Biophys Res Comm un 358
  
  Pages: 253-258
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Dihydroorotate dehydrogenase arises from novel fused gene product with aspartate carbamoyltransferase in Bodo saliensfus2007
- Author(s)
  Annoura T, Sariego I, Nara T, Makiuchi T, Fujimura T, Taka H, Mineki R, Murayama K, Aoki T
- Journal Title
  
  Biochemical and Biophysical ResearchCommunications 358
  
  Pages: 253-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Antibody isotype responses to paramyosin, a vaccine candidate for schistosomiasis, and their correlations with resistance and fibrosis in patients infected with Schistosomiasis japonicum in Leyte, The Philippines2007
- Author(s)
  Nara T, Iizumi K, Ohmae H, Sy OS, Tsubota S, Inaba Y, Tsubouchi A, Tanabe M, Kojima S, Aoki T
- Journal Title
  
  American Journal of Tropical Medicine and Hygiene 76
  
  Pages: 384-391
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Occurrence of multiple, independent gene fusion events for the fifth and sixth enzymes of pyrimidine biosynthesis in different eukaryotic groups2007
- Author(s)
  Makiuchi, T., Nara, T., Annoura, T., Hashimoto, T., Aoki, T
- Journal Title
  
  Gene 394
  
  Pages: 78-86
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms2006
- Author(s)
  Sariego I, Annoura T, Nara T, Hashimoto M, Tsubouchi A, Iizumi K, Makiuchi T, Murata E, Kita K, Aoki T
- Journal Title
  
  Parasitology International 55
  
  Pages: 11-16
- NAID
  10017321391
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Molecular cloning and characterization of ouabain-insensitive Na+-ATPase in the parasitic protist, Trypanosoma cruzi2006
- Author(s)
  Iizumi, K., Mikami, Y., Hashimoto, M., Nara, T., Hara, Y., Aoki
- Journal Title
  
  Biochim BiophysActa Biomembranes 1758
  
  Pages: 738-746
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Molecular cloning and characterization of ouabain-insensitive Na^+-ATPase in the parasitic protist, Trypanosoma cruzi2006
- Author(s)
  Iizumi K, Mikami Y, Hashimoto M, Nara T, Hara Y, Aoki T
- Journal Title
  
  Biochimica et Biophysica Acta-Biomembranres 1758
  
  Pages: 738-746
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Molecular cloning and characterization of ouabain-insensitive Na^+-ATPase in the parasitic protist,Trypanosoma cruzi2006
- Author(s)
  Iizumi K, Mikami Y, Hashimoto M, Nara T, Hara Y, Aoki T
- Journal Title
  
  Biochimica et Biophysica Acta-Biomembranres 1758
  
  Pages: 738-746
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms2006
- Author(s)
  Sariego, I., Annoura, T., Nara, T., Hashimoto, M., Tsubouchi, A., Iizumi, K., Makiuchi, T., Murata, E., Kita, K., Aoki, T
- Journal Title
  
  Parasitollnt 55
  
  Pages: 11-16
- NAID
  10017321391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme2005
- Author(s)
  Uchiyama N, Kabututu Z, Kubata BK, Kiuchi F, Ito M, Nakajima-Shimada J, Aoki T, Ohkubo K, Fukuzumi S, Martin SK, Honda G, Urade Y
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 49
  
  Pages: 5123-5126
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate2005
- Author(s)
  Inaoka, DK., Takashima, E., Osanai, A., Shimizu, H., Nara, T., Aoki, T., Harada, S., Kita, K
- Journal Title
  
  Acta Cryst F61
  
  Pages: 875-878
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Expression,purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate2005
- Author(s)
  Inaoka DK, Takashima E, Osanai A, Shimizu H, Nara T, Aoki T, Harada S, Kita K
- Journal Title
  
  Acta Crystallographica F61
  
  Pages: 875-878
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Gene expression profiles in response to Fas stimulation in Trypanosoma cruzi-infected host cells2005
- Author(s)
  Hashimoto M, Nakajima-Shimada J, Ishidoh K, Aoki T
- Journal Title
  
  International Journal for Parasitology 35
  
  Pages: 1587-1594
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions2005
- Author(s)
  Annoura, T., Nara, T., Makiuchi, T., Hashimoto, T., Aoki, T
- Journal Title
  
  JMol Evol 60
  
  Pages: 113-127
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydro-genase activity and on the protozoan growth in mammalian cells.2005
- Author(s)
  Nara T, Kamei Y, Tsubouchi A, Annoura T, Hirota K, Iizumi K, Dohmoto Y, Ono T, Aoki T
- Journal Title
  
  Parasitol Int 54
  
  Pages: 59-64
- NAID
  10015455204
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells2005
- Author(s)
  Nara T, Kamei Y, Tsubouchi A, Annoura T, Hirota K, Iizumi K, Dohmoto Y, Ono T, Aoki T
- Journal Title
  
  Parasitology International 54
  
  Pages: 59-64
- NAID
  10015455204
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids,with special reference to their biological significance and adaptation to anaerobic,parasitic conditions2005
- Author(s)
  Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T
- Journal Title
  
  Journal of Molecular Evolution 60
  
  Pages: 113-127
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Trypanosoma cruzi post-transcriptionally upregulates and exploits cellular FLIP for inhibition of death-inducing signal2005
- Author(s)
  Hashimoto, M., N.-Shimada, J., Aoki, T
- Journal Title
  
  Mol Biol Cell 16
  
  Pages: 3521-3528
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Gene Expression profiles in response to Fas stimulation in Trypanosoma cruzrinfected host cells2005
- Author(s)
  Hashimoto, M., Nakajima-Shimada, J., Ishidoh, K., Aoki, T
- Journal Title
  
  Int J Parasitol 35
  
  Pages: 1587-1594
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells2005
- Author(s)
  Nara T, Kamei Y, Tsubouchi A, Annoura T, Hirota K, Iizumi K, Dohmoto Y, Ono T, Aoki T
- Journal Title
  
  Parasitology International 54
  
  Pages: 59-64
- NAID
  10015455204
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions.2005
- Author(s)
  Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T
- Journal Title
  
  J Mol Evol 60
  
  Pages: 113-127
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Trypanosoma cruzi posttranscriptionally up-regulates and exploits cellular FLIP for inhibition of death-inducing signal2005
- Author(s)
  Hashimoto M, N.-Shimada J, Aoki T
- Journal Title
  
  Molecular Biology of the Cell 16
  
  Pages: 3521-3528
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Trypanosoma cruzi post-transcriptionally upregulates cellular FLIP for inhibition of death-inducing signal2005
- Author(s)
  Hashimoto M, N.-Shimada J, Aoki T
- Journal Title
  
  Molecular Biology of the Cell (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Trypanosome cruzi posttranscriptionally up-regulates and exploits cellular FLIP for inhibition of death-inducing signal2005
- Author(s)
  Hashimoto M, N.-Shimada J, Aoki T
- Journal Title
  
  Molecular Biology of the Cell 16
  
  Pages: 3521-3528
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions2005
- Author(s)
  Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T
- Journal Title
  
  Journal of Molecular Evolution 60
  
  Pages: 113-127
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase and on the protozoan growth in mammalian cells2005
- Author(s)
  Nara T, Kamei Y, Tsubouchi A, Annoura T, Hirota K, Iizumi K, Dohmoto Y, Ono T, Aoki T
- Journal Title
  
  Parasitology International 54
  
  Pages: 59-64
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme2005
- Author(s)
  Uchiyama, N., Kabututu, Z., Kubata, BK., Kiuchi, F., Ito, M., Nakajima-Shimada, J., Aoki, T., Ohkubo, K., Fukuzumi, S., Martin, SK., Honda, G., Urade, Y
- Journal Title
  
  Antimicrob Agents Chemother 49
  
  Pages: 5123-5126
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate2005
- Author(s)
  Inaoka DK, Takashima E, Osanai A, Shimizu H, Nara T, Aoki T, Harada S, Kita K
- Journal Title
  
  Acta Crystallographica F61
  
  Pages: 875-878
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions2005
- Author(s)
  Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T
- Journal Title
  
  Journal of Molecular Evolution 50
  
  Pages: 112-127
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions2005
- Author(s)
  Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T
- Journal Title
  
  Journal of Molecular Evolution 60
  
  Pages: 113-127
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells2005
- Author(s)
  Nara, T., Kamei, Y., Tsubouchi, A., Annoura, T., Hirota, K., Iizumi, K., Dohmoto, Y, Ono, T., Aoki, T
- Journal Title
  
  Parasitollnt 54
  
  Pages: 59-64
- NAID
  10015455204
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Trypanosoma cruzi抗原と作用するヒト心筋細胞タンパク質のファージディスプレイ法による解析2004
- Author(s)
  吉田彩子, 奈良武司, 青木孝
- Journal Title
  
  第73回日本寄生虫学会大会プログラム・抄録集
  
  Pages: 60-60
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Inhibition of Trypanosome cruzi growth in mammalian cells by nimodipine, with low cytotoxicity to host cells2004
- Author(s)
  Hirota K, Tsubouchi A, N.-Shimada J, Nara T, Aoki T
- Journal Title
  
  Tropical Medicine and Health 32
  
  Pages: 181-188
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Inhibition of Trypanosoma cruzi growth in mammalian cells by nimodipine, with low cytotoxicity to host cells2004
- Author(s)
  Hirota K, Tsubouchi A, N.-Shinada J, Nara T, Aoki T
- Journal Title
  
  Tropical Medicine and Health 32
  
  Pages: 181-188
- NAID
  10013297272
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Inhibition of Trypanosoma cruzi growth in mammalian cells by nimodipine, with low cytotoxicity to host cells.2004
- Author(s)
  Hirota K, Tsubouchi A, N.-Shimada J, Nara T, Aoki T
- Journal Title
  
  Trop Med Health 32
  
  Pages: 181-188
- NAID
  10013297272
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Trypanosoma cruzi抗原と作用するヒト心筋細胞タンパク質のファージデイスプレイ法による解析2004
- Author(s)
  吉田彩子, 奈良武司, 青木孝
- Journal Title
  
  第73回日本寄生虫学会大会プログラム・抄録集
  
  Pages: 60-60
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Trypanocidal constituents from Michelia alba.2003
- Author(s)
  Asaruddin MR, Honda G, Tsubouchi A, Nakajima-Shimada J, Aoki T, Kiuchi F
- Journal Title
  
  Natural Medicines 57
  
  Pages: 61-63
- NAID
  50000804055
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection.2003
- Author(s)
  Miyahira Y, Katae M, Kobayashi S, Takeuchi T, Fukuchi Y, Abe R, Okumura K, Yagita H, Aoki T
- Journal Title
  
  Infect Immun 71
  
  Pages: 3131-3137
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Metabolism parasitic protozoa2003
- Author(s)
  Aoki T
- Journal Title
  
  Progress of Medical Parasitology in Japan (edited by M Otsuru et al.)(Megro Parasitological Museum, Tokyo) Vol.7,Chapter III
  
  Pages: 175-191
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection2003
- Author(s)
  Miyahira Y, Katae M, Kobayashi S, Takeuchi T, Fukuchi Y, Abe R, Okumura K, Yagita H, Aoki T
- Journal Title
  
  Infect Immun 71
  
  Pages: 3131-3137
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Trypanocidal constituents from Michelia alba2003
- Author(s)
  Asaruddin MR.Honda G, Tsubouchi A, N.-Shinada J, Aoki T, Kiuchi F
- Journal Title
  
  Natural Medicines 57
  
  Pages: 61-63
- NAID
  50000804055
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Diversity of aspartate carbamoyltransferase genes of Trypanosoma cruzi2003
- Author(s)
  Nara T, Hirayama-Noguchi Y, Gao G, Murai E, Annoura T, Aoki T
- Journal Title
  
  Int J Parasitol 33
  
  Pages: 845-852
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Diversity of aspartate carbamoyltransferase genes of Trypanosoma cruzi.2003
- Author(s)
  Nara T, Hirayama-Noguchi Y, Gao G, Murai E, Annoura T, Aoki T
- Journal Title
  
  Int J Parasitol 33
  
  Pages: 845-852
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Trypanosoma cruzi post-transcriptionally upregulates cellular FLIP for inhibition of death-inducing signal.
- Author(s)
  Hashimoto M, N.-Shimada J, Aoki T
- Journal Title
  
  Mol Biol Cell (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390138
[Journal Article] Occurrence of multiple, independent gene fusion events for the fifth and sixth enzymes of pyrimidine biosynthesis in different eukaryotic groups
- Author(s)
  Makiuchi T, Nara T, Annoura T, Hashimoto T, Aoki T
- Journal Title
  
  Gene (in press)
- Data Source
  KAKENHI-PROJECT-17390123
[Presentation] Evolutionary analysis of synteny and gene fusion for pyrimidine biosynthetic enzymes in Euglenozoa : An extraordinary gap between kinetoplastids and diplonemids2010
- Author(s)
  Makiuchi T, Annoura T, Hashimoto T, Aoki T, Nara T
- Organizer
  XIIth International Congress of Parasitology (ICOPA)
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-21653043

1. SHIMADA Junko (20211964)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
2. TAKAMIYA Shinzaburo (90138206)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. NARA Takeshi (40276473)

# of Collaborated Projects: 5 results

# of Collaborated Products: 37 results
4. SHIMOGAWARA Rieko (50146776)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. TSUBOUCHI AKIKO (10398662)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. KIUCHI Fumiyuki (60161402)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YAMASAKI Hiroshi (00138207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YOSHIDA Ayako (20343486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. HASHIMOTO Muneaki (30407308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
10. ANNOURA TAKESHI (90407239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
11. KITA Kiyoshi (90134444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 丸井英二 (30111545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AOKI Takashi 青木 孝

Research Projects

Research Products

Co-Researchers

新型インフルエンザ; リスク認知とリスク回避行動の関係についての実証的研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TRYPANASOMAGRUZI : MOLECULAR BASES FOR INTRACELLULAR PARASITISM, PROLIFERATION, AND PATHOGENICITY IN INFECTED HUMAN CELLSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MOLECULAR STRATEGIES OF TRYPANOSOMA CRUZI IN REMODELING AND CONTROLLING THE INFECTED HOST CELLSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular characterization of all the six enzymes and their corresponding genes involved in de novo pyrimidine biosynthesis in trypanosomatidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of Anti-trypanosomal Drugs Based on Terpene Structure as an Active Unit

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ネズミマラリア原虫ミトコンドリア呼吸鎖成分の生化学解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

A Search for Naturally Occurring Anti-trypanosomal Compounds Using a HeLa Cell Infection Assay System

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ネズミマラリア原虫ミトコンドリア呼吸鎖成分の生化学的解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ネズミマラリア原虫ミトコンドリア呼吸鎖成分の生化学的解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Molecular characterization of CPS II and ACT genes form Trypanosoma cruziPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of an in vitro screening system for anti-Trypanosoma cruzi agentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular and biochemical studies on the enzymes of nucleic acid precursor synthesis unique to trypanosomatid parasitesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biosynthesis of Nucleic Acid Precursors and Its Inhibition in Trypanosomatid ParasitesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comparative studies on pyrimidine nucleotide biosynthesis characteristic of parasitic protozoaPrincipal Investigator

AOKI Takashi 青木孝