OHSAWA Takako 大沢多加子

Researcher Number	20073017
Affiliation (based on the past Project Information) *help	2002: 東京都老人総合研究所, 遺伝子情報研究グループ, 主任研究員 1996: Tokyo Metropolitan Institute of Gerontology Department of Cell Chemistry Senior, 細胞化学部門, 研究員 1995 – 1996: (財)東京都老人総合研究所, 分子老化学研究系・細胞化学部門, 研究員
Review Section/Research Field	Except Principal Investigator Experimental pathology / Functional biochemistry
Keywords	Except Principal Investigator peptidylarginine deiminase / ペプチジルアルギニンデイミナーゼ / proteome / aging / astrocyte / myelin basic protein / citrullinated protein / Alzheimer's disease / neurodegenerative disorder / グリア細胞 … More / チュブリン / シトルリン / 脱イミノ化蛋白質 / 蛋白質脱イミノ化酵素 / プロテオーム / 老化 / アストロサイト / ミエリン塩基性蛋白質 / シトルリン化蛋白質 / アルツハイマー病 / 神経変性疾患 / filaggrin / keratins / cornification / keratinocytes / deiminated proteins / ペプチジルアルギニンデミナーゼ / フィラグリン / ケラチン / 角化 / 表皮細胞 / 脱イミノ化タンパク質 Less

Molecular pathological analysis of citrullinated proteins in the brain from neurodegenerative disorder patients.
- Principal Investigator
  
  ISHIGAMI Akihito
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
Functional Significance of Protein Deimination during the Cornification of Epidermis
- Principal Investigator
  
  SENSHU Tatsuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Metropolitan Institute of Gerontology

All 2005 2004 2002

All Journal Article

[Journal Article] Abnormal accumulation of deiminated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.2005
- Author(s)
  Ishigami, A., Ohsawa, T., Hiratsuka, M., Taguchi, H., Kobayashi, S., Saito, Y., Murayama, S., Asaga, H., Toda, T., Kimura, N., Maruyama, N.
- Journal Title
  
  J.Neurosci.Res. 80
  
  Pages: 120-128
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570210
[Journal Article] Abnormal accumulation of deiminated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.2005
- Author(s)
  Ishigami, A., Ohsawa, T., Hiratsuka, M., Taguchi, H.et al.
- Journal Title
  
  J.Neurosci.Res. (in press)
- Data Source
  KAKENHI-PROJECT-14570210
[Journal Article] Abnormal accumulation of deiminated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.2005
- Author(s)
  Ishigami, A., Ohsawa, T.et al.
- Journal Title
  
  J.Neurosci.Res. 80
  
  Pages: 120-128
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570210
[Journal Article] SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span.2004
- Author(s)
  Ishigami, A., Kondo, Y., Nanba, R., Ohsawa, T., Handa, S.et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 315
  
  Pages: 575-580
- NAID
  40006236477
- Data Source
  KAKENHI-PROJECT-14570210
[Journal Article] Human peptidylarginine deiminase type II : Molecular cloning, gene organization and expression in human skin.2002
- Author(s)
  Ishigami, A., Ohsawa, T., Asaga, H., Akiyama, K, Kuramoto, M., Maruyama, N.
- Journal Title
  
  Arch.Biochem.Biophys. 407
  
  Pages: 25-31
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570210
[Journal Article] Human peptidylarginine deiminase type II : Molecular cloning, gene organization and expression in human skin.2002
- Author(s)
  Ishigami, A., Ohsawa, T.et al.
- Journal Title
  
  Arch.Biochem.Biophys. 407
  
  Pages: 25-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570210
[Journal Article] Protein deimination and peptidylarginine deiminase expression during cornification of rat epidermal keratinocytes.2002
- Author(s)
  Ishigami, A., Asaga, H., Ohsawa, T., Akiyama, K., Maruyama, N.
- Journal Title
  
  Biomed.Res. 23
  
  Pages: 145-151
- NAID
  130004713403
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570210
[Journal Article] Increased and type II-specific expression of peptidylarginine deiminase in activated microglia but not hyperplastic astrocytes following kainic acid-evoked neurodegeneration in the rat brain.2002
- Author(s)
  Asaga, H., Akiyama, K., Ohsawa, T., Ishigami, A.
- Journal Title
  
  Neurosci.Lett. 326
  
  Pages: 129-132
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570210

1. ISHIGAMI Akihito (50270658)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. ASAGA Hiroaki (80231877)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. SENSHU Tatsuo (60072998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. AKIYAMA Kyoichi (10110024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MARUYAMA Naoki (00115940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. HANDA Setsuko (30360697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

OHSAWA Takako 大沢 多加子

Research Projects

Research Products

Co-Researchers

Molecular pathological analysis of citrullinated proteins in the brain from neurodegenerative disorder patients.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional Significance of Protein Deimination during the Cornification of Epidermis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Abnormal accumulation of deiminated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Abnormal accumulation of deiminated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.2005

Author(s)

Journal Title

Data Source

[Journal Article] Abnormal accumulation of deiminated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span.2004

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Human peptidylarginine deiminase type II : Molecular cloning, gene organization and expression in human skin.2002

Author(s)

Journal Title

Description

Data Source

[Journal Article] Human peptidylarginine deiminase type II : Molecular cloning, gene organization and expression in human skin.2002

Author(s)

Journal Title

Description

Data Source

[Journal Article] Protein deimination and peptidylarginine deiminase expression during cornification of rat epidermal keratinocytes.2002

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Increased and type II-specific expression of peptidylarginine deiminase in activated microglia but not hyperplastic astrocytes following kainic acid-evoked neurodegeneration in the rat brain.2002

Author(s)

Journal Title

Description

Data Source

OHSAWA Takako 大沢多加子