SHIONO Hiroshi 塩野寛

Researcher Number	20112451
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2004 – 2005: 旭川医科大学, 医学部, 副学長 1997 – 2003: 旭川医科大学, 医学部, 教授 1992 – 1995: 旭川医科大学, 医学部, 教授 1991 – 1992: 島根医科大学, 医学部, 教授 1988 – 1989: Shimane Medical University, 医学部, 教授
Review Section/Research Field	Principal Investigator Legal medicine / Legal medicine Except Principal Investigator Legal medicine
Keywords	Principal Investigator 性染色体 / マイクロサテライト / sex chromosome / microsatellite / allele distribution / Paternity testing / DNA polymorphisms / VNTR makers / Polymerase Chain Reaction / Personal identification … More Except Principal Investigator ECD / β-カルボリン / パーキンソン氏病 / 神経毒性 / N-メチル化酵素 / 人脳 / 環境毒 / 農薬 / パラコート / 神経変性疾患 / 神経興奮毒性 / パーキンソン病 / 線条体 / 遠隔授業 / 法医学 / コンピュータ / ネットワーク / 情報処理 / 単位互換 / 自己学習 / DNA分析 / 性別判定 / ポリメレース連鎖反応(PCR) / 性染色体 / アメロゲニン遺伝子 / ヘモグロビン / ヘマチン / ポリメレース・チェイン・リアクション(PCR)法 / DNA分解 / ポリメレ-ス・チェイン・リアクション(PCR)法 / DYZ1 / 縦列型反復配列遺伝子 / 単一コピ-遺伝子 / DNA analysis / Sex determination / Polymerase chain reaction / Sex chromosomes / Amelogenin gene / Degradation of DNA / Hemoglobin / Hematin / 自殺 / 脳内アミン / 遺伝子頻度 / DNA型 / セロトニンレセプター / トリプトファンハイドロキシレース / セロトニントランスポーター / Suicide / Neurotransmitter / Allele Frequency / DNA Type / Serotonin Receptor 1A Gene / Tryptophan Hydroxylase Gene / 大麻 / Δ^9ーテトラヒドロカンナビノール / キャピラリーカラムー電子捕獲型検出器付ガスクロマトグラフ / △^9-テトラヒドロカンナビノール / キャピラリーカラム-電子補獲型検出器付ガスクロマトグラフ / マリファナ喫煙 / キャピラリーGC / ダ液 / Toxicology / Marihuana smoking / ^9-Tetrahydrocannabinol / Capillary GC / Saliva Less

Study on the toxicological mechanism of paraquat-induced pulmonary fibrosis and its tentative therapeuticsPrincipal Investigator
- Principal Investigator
  
  SHIONO Hiroshi, 清水惠子
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Asahikawa Medical College
パラコート中毒における中枢毒性発現機序に関する研究
- Principal Investigator
  
  SHIMIZU Keiko (清水恵子)
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Asahikawa Medical College
法医学授業の他大学との連携・単位互換性の検討
- Principal Investigator
  
  YOSHIOKA Naofumi
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Akita University
The Establishment of diagnosis and the forensic pathological study on death in the cold.Principal Investigator
- Principal Investigator
  
  SHIONO Hiroshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Asahikawa Medical College
Association study between the polymorphisms of neurotransmitter-related genes and suicide behavior.
- Principal Investigator
  
  YOSHIOKA Naofumi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Legal medicine
- Research Institution
  Akita University
Polymorphism of Microsatellite Markers on Human Sex Chromosomes and analysis of mutation rate in the same individual.Principal Investigator
- Principal Investigator
  
  SHIONO Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Asahikawa Medical College
Polymorphism and Genetic Instability of Microsatellite Markers on Human Sex Chromosomes.Principal Investigator
- Principal Investigator
  
  SHIONO Hiroshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Asahikawa Medical College
性染色体上マーカーの分子生物学的解析と法医学試料への応用Principal Investigator
- Principal Investigator
  
  塩野寛
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Asahikawa Medical College
分子生物学的手法を用いた性染色体DNA多型の法医学試料への応Principal Investigator
- Principal Investigator
  
  塩野寛
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Asahikawa Medical College
β-カルボリンの脳内での活性化による神経毒の生成機序と肝における解毒化活性
- Principal Investigator
  
  松原和夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Shimane Medical University
Investigation on dual PCR technique and its application to sex determination of forensic specimensPrincipal Investigator
- Principal Investigator
  
  MATSUBARA Kazuo, 塩野寛
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Shimane Medical University
DNA解析の法医遺伝学的応用Principal Investigator
- Principal Investigator
  
  塩野寛
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Shimane Medical University
Study of the proof for marihuana smoking by gas chromatographic analysis
- Principal Investigator
  
  TAKAHASHI Setsunori
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Shimane Medical University

All 2006 2004 2003

All Journal Article

[Journal Article] Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions.2006
- Author(s)
  K.Matsubara, K Shimizu, M Suno, K.Ogawa, T.Awaya, T.Yamada, T.Noda, M.Satomi, K.Ohtaki, K.Chiba, Y.Tasaki, H.Shiono
- Journal Title
  
  Brain Research (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590571
[Journal Article] Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions.2006
- Author(s)
  K.Matsubara, K.Shimizu, M.Suno, K.Ogawa, T.Awaya, T.Yamada, T.Noda, M.Satomi, K.Ohtaki, K.Chiba, Y.Tasaki, H.Shiono
- Journal Title
  
  Brain Research, (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590571
[Journal Article] 急性パラコート中毒による末梢毒性機構の解明とその阻止薬の探索2004
- Author(s)
  清水恵子, 塩野寛他
- Journal Title
  
  日本法医学雑誌 58・1
  
  Pages: 77-77
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590571
[Journal Article] 急性パラコート中毒による末梢毒性機構の解明とその阻止薬の探索2004
- Author(s)
  清水恵子, 塩野寛他
- Journal Title
  
  日本法医学雑誌 58・1
  
  Pages: 77-77
- Data Source
  KAKENHI-PROJECT-15590571
[Journal Article] Study on the mechanism of peripheral acute toxicity induced by paraquat and its tentative therapeutics.2004
- Author(s)
  K Shimizu, M Asari, H Shiono, K Matsubara, K Ohotaki, T Awaya
- Journal Title
  
  Japanese Journal of Legal Medicine 58
  
  Pages: 77-77
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590571
[Journal Article] Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release.2004
- Author(s)
  K.Ohtaki, K.Matsubara, S.Fujimaru, K.Shimizu, T.Awaya, M.Suno, K.Chiba, N.Hayase, H.Shiono
- Journal Title
  
  Journal of Neural Transmission 12
  
  Pages: 1523-1535
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590571
[Journal Article] Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture.2003
- Author(s)
  K.Shimizu, K.Matsubara, K.Ohtaki, H.Shiono
- Journal Title
  
  Brain Research 46
  
  Pages: 523-532
- NAID
  10016207557
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590571
[Journal Article] Pralidoxime iodide (2-pAM) penetrates across the blood-brain barrier.2003
- Author(s)
  K.Sakurada, K.Matsubara, K.Shimizu, H.Shiono, Y.Seto, K.Tsuge, M.Yoshino, I.Sakai, H.Mukoyama, T.Takatori
- Journal Title
  
  Neurochemical Research 28
  
  Pages: 1401-1407
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590571
[Journal Article] Pralidoxime iodide(2-pAM)penetrates across the blood-brain barrier.2003
- Author(s)
  K.Sakurada, K.Matsubara, K.Shimizu, H.Shiono, Y.Seto, K.Tsuge, M.Yoshino, I.Sakai, H.Mukoyama, T.Takatori
- Journal Title
  
  Neurochemical Research 28:
  
  Pages: 1401-7
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590571
[Journal Article] Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture.2003
- Author(s)
  K.Shimizu, K.Matsubara, K.Ohtaki, H.Shiono
- Journal Title
  
  Brain Research 46:
  
  Pages: 523-32
- NAID
  10016207557
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590571
[Journal Article] Paraquat induces long-lasting toxicity to striatal dopaminergic terminals through the excitotoxic pathway.2003
- Author(s)
  K.Shimizu, K.Matsubara, K.Ohtaki, S.Fujimaru, O.Saito, H.Shiono
- Journal Title
  
  Brain Research 976
  
  Pages: 243-52
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590571

1. MATSUBARA Kazuo (20127533)

# of Collaborated Projects: 7 results

# of Collaborated Products: 9 results
2. SHIMIZU Keiko (90312462)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
3. TAKAHASHI Setsunori (90032226)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. SASAKI Masahiro (80250546)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. AKANE Atsushi (70202520)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. YOSHIOKA Naofumi (80108935)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. UEZONO Takashi (70294387)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KIMURA Kojiro (30153191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FUKUSHIMA Tohru (30199210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHIZU Hideo (70033157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KATSUMATA Yoshinao (30109326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKASONO Ichirou (30108287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ASARI Masaru (40360979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. AZUMI Jun-ichi (00045551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 池淵淳 (30150361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 権守邦夫 (10006744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 中村彰 (20155815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 福永龍繁 (70156800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 福島弘文 (70135218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 浜久美子 (50167590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIONO Hiroshi 塩野 寛

Research Projects

Research Products

Co-Researchers

Study on the toxicological mechanism of paraquat-induced pulmonary fibrosis and its tentative therapeuticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

パラコート中毒における中枢毒性発現機序に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

法医学授業の他大学との連携・単位互換性の検討

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Establishment of diagnosis and the forensic pathological study on death in the cold.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Association study between the polymorphisms of neurotransmitter-related genes and suicide behavior.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Polymorphism of Microsatellite Markers on Human Sex Chromosomes and analysis of mutation rate in the same individual.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Polymorphism and Genetic Instability of Microsatellite Markers on Human Sex Chromosomes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

性染色体上マーカーの分子生物学的解析と法医学試料への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

分子生物学的手法を用いた性染色体DNA多型の法医学試料への応Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

β-カルボリンの脳内での活性化による神経毒の生成機序と肝における解毒化活性

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Investigation on dual PCR technique and its application to sex determination of forensic specimensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNA解析の法医遺伝学的応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of the proof for marihuana smoking by gas chromatographic analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

SHIONO Hiroshi 塩野寛