AZUMA Hiroshi 東洋

Researcher Number	20134736
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2008: 東京医科歯科大学, 生体材料工学研究所, 教授 2004: Institute of Biomaterials and Bioengineering, Department of Biosystem Regulation, Professor, 生体材料工学研究所, 教授 2002 – 2004: 東京医科歯科大学, 生体材料工学研究所, 教授 2003: Tokyo Medical and Dental University, Professor 2000 – 2001: 東京医科歯科大学, 生体工学研究所・分子設計部門, 助教授 … More 1999 – 2001: 東京医科歯科大学, 生体材料工学研究所, 助教授 1998: Ph.D., associate professor, Institute for Medical and Dental Engineering, Tokyo, 医学器材研究所, 助教授 1998: 東京医科歯科大学, 医用機材研究所, 助教授 1995 – 1998: 東京医科歯科大学, 医用器材研究所, 助教授 1996: TOKYO MEDICAL AND DENTAL UNIVERSITY,MEDICAL CHEMISTRY,FACULTY OF MEDICINE AND IN, 医用機材研究所, 助教授 1994: 東京医科歯科大学, 医用機材研究所, 助教授 Less
Review Section/Research Field	Principal Investigator 応用薬理学・医療系薬学 Except Principal Investigator Urology / Pediatrics / Obstetrics and gynecology / Cerebral neurosurgery
Keywords	Principal Investigator Aldose reductase / endothelin-1 / Ornithine aminotransferase / Ornithine decarboxylase / Polyamines / Endogenous NOS inhibitors / Enhanced arginase activity / Hyperglycemia / polyol pathway / 高血糖 … More / 内膜肥厚 / 内因性NOS阻害物質 / Endogenous arginase inhibitor / Acceleration of intimal hyperplasia / Vascular remodeling / Proline / Nitric oxide / Nitric oxide synthase / L-Arginine / Polyamine / OAT / ODC / Ornithine / DDAH / Arginase / NO synthase / omithine decarboxvlase (ODC) / putrescine / N^G-hydroxy-L-arginine / arginase活性亢進 / 内膜肥厚増悪 / Accelerated intimal hyperplasia / sorbitol / nitric oxide / hvperglycemia / endogenous NOS inhibitors / augmentation of intimal hvperplasia / alloxan / 内膜剥離術 / aldose reductase inhibitor (ARI) / ソルビトール / ポリオール経路 / 一酸化窒素 / エンドセリン-1 / 内膜肥厚の増悪 / アルドース還元酵素 / Extracellular matrices / Growth of smooth muscle cells / Endothelial cells / Vascular injury / Intimal hyperplasia / Inhibitors for NO synthesis / ADMA / L-NMMA / EDRF / p-53遺伝子発現 / p-53蛋白 / 内因性阻害物質 / NO合成酸素(NOS) / 動脈硬化 / 細胞外マトリックス / 高血圧 / 急性腎症 / 遠近調節 / 毛様体筋 / 細胞増殖 / NO … More Except Principal Investigator arginase / K^+ ion / EDHF / 一酸化窒素合成酵素(NOS) / 一酸化窒素(NO) / nitric oxide / cyclic GMP / penile erection / 陰茎海綿体 / 陰茎勃起 / 一酸化窒素 / エンドセリン / VIP / PACAP / prolonged QT / monocrotaline induced pulmonary artery hypertension model rats / in vivo electrophysiological studies / 心臓電気生理学的検査 / 病理的心筋リモデリング / 電気的心筋リモデリング / 肺高血圧ラット / QT延長 / モノクロタリン誘発肺高血圧ラット / 臨床心臓電気生理学的検査 / dimenthylarginine dimethylaminohydrolase (DDAH) / L-arginine / ornithine decarboxylase (ODC) / endogenos NOS inhibitors / nitric oxide synthase (NOS) / pulmonary vascular remodeling / pulmonary hypertension (PH) / DDAH / ODC / 内因性NO合成酵素阻害物質 / eNOS / 肺高血圧 / ジメチルアルギニン・ジメチルアミノハイドロラーゼ(DDAH) / L-アルギニン / オルニチン・デカルボキシラーゼ(ODC) / 内因性NO合成酵素阻害物質(NOS inhibitors) / アルギナーゼ / 肺血管リモデリング / 肺高血圧(PH) / metabolite(s) of P_<450> mono-oxygenase / CCh-induced relaxation / Hind-limb perfusion model / 内皮依存性過分極因子(EDHF) / 末梢血管 / H_2O_2 / 下肢還流モデル / 末梢血管抵抗 / 妊娠 / K^+ / 内皮依存性脱分極因子(EDHF) / ラットの下肢潅流モデル / ラット下肢潅流モデル / P_<450> mono-oxygenase代謝産物 / CCh誘発弛緩 / 後枝潅流モデル / endogenous NOS inhibitors / hyperglylcemia / ischemia / nitric oxide svnthase / corpus cavernosum / erectile dysfunction(ED) / 陰茎海面体 / guanylate cyclase / NOS / 勃起障害 / 内因性NOS阻害物質 / 高血糖 / 虚血 / nitric oxide synthase / impotence / vasoactive intestinal polypeptide (VIP) / pituitary adenylate activation polypeptide (PACAP) / neuropeptide / neurotransmitter / 精管 / アドレナリン受容体 / 尿道 / ムスカリン受容体 / インポテンス / 神経ペプチド / 神経伝達物質 / 子宮筋弛緩 / 子宮筋収縮 / ENDOTHELIN / INSULIN-LIKE GROWTH FACTOR (IGF) / ANDROGEN / PROSTATE / 培養細胞 / 成長因子 / アンドロジェン / パラクリン / IGF-II / エントセリン / インスリン様成長因子 / アンドロゲン / 前立腺 / 新生内膜増殖性病変 / 肺動脈性高血圧 / PAHモデルラット / 肺小動脈理モデリング / 血管内皮細胞増殖因子受容体阻害剤 / 精巣・卵巣摘出 / 性ステロイド / 性差 / 血管内皮細胞増殖因子受容体阻害剤SU-5416 / 肺細小動脈新生内膜増殖性変化 / 肺動脈性肺高血圧 / mRNA / SAH Less

Effects of sex steroids on pulmonary hypertension-From the standpoint of sex difference in idiopathic pulmonary arterial hypertension-
- Principal Investigator
  
  DOI Shouzaburou
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Medical and Dental University
Research for the clarification of the modulating mechanisms of pulmonary vascular remodeling associated with pulmonary hypertension
- Principal Investigator
  
  DOI Shozaburo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Medical and Dental University
Interaction Between Electrical and Pathological Myocardial Remodeling Induced by Right and Left Ventricular Pressure Overload
- Principal Investigator
  
  WAKIMOTO Hiroko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Medical and Dental University
Acceleration of intinul hyperplasia by the enhanced arginase activity due to hyperglycemiaPrincipal Investigator
- Principal Investigator
  
  AZUMA Hiroshi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo Medical and Dental University
Research for the role of endothelium-dependent relaxation in the change of maternal circulation during pregnancy
- Principal Investigator
  
  SAKAMOTO Shuichi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Tokyo Medical and Dental University
Possible involvement of facilitated aldose reductase activity in the accelerated vascular remodeling in rabbits with alloxan-induced hyperglycemiaPrincipal Investigator
- Principal Investigator
  
  AZUMA Hiroshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo Medical and Dental University
Role of endogenous nitric oxide synthase inhibitors in penile erection and their potential use in the treatment of erectile dysfunction.
- Principal Investigator
  
  TSUJII Toshihiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Dokkyo University School of Medicine
  Tokyo Medical and Dental University
PACAPによる脳幹部機能異常の調節に関する研究
- Principal Investigator
  
  ISOTANI Eiji
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tokyo Medical and Dental University
Study of the role of pituitary adenylate cyclase activating polypeptide (PACAP) as a neurotransmitter in the urogenital organs.
- Principal Investigator
  
  TSUJII Toshihiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Tokyo Medical and Dental University School of Medicine
子宮筋における各種収縮・弛緩因子の相互作用による収縮弛緩調節に関する研究
- Principal Investigator
  
  ASO Takeshi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Tokyo Medical and Dental University
Regulation of NOS activity by the endogenous inhibitors and modification of hyperplastic vascular diseases with the inhibitors.Principal Investigator
- Principal Investigator
  
  AZUMA Hiroshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo Medical & Dental University
REGULATION OF PROSTATIC GROWTH AND FUNCTION BY EPITHELIAL-STROMAL INTERACTION AND TESTICULAR FACTOR.
- Principal Investigator
  
  ISHIZAKA Kazuhiro
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  TOKYO MEDICAL AND DENTAL UNIVERSITY

All 2005 2004 2003 2002

All Journal Article

[Journal Article] Accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity attenuated dimethylarginine dimethylaminohydrolase activity and2005
- Author(s)
  Loyaga-Rendon RY, Sakamoto S, Beppu M, Aso T, Azuma H
- Journal Title
  
  Atherosclerosis 178
  
  Pages: 231-239
- Data Source
  KAKENHI-PROJECT-14572152
[Journal Article] Involvement of accumulated endogenous NOS inhibitors and accelerated arginase activity in impairing the NO production in pulmonary arterial hypertension of the rat.2005
- Author(s)
  Sasaki A, Doi S, Wakimoto H, Takahashi R, Azuma H.
- Journal Title
  
  American Journal of Respiratory and Critical Care Medicine Vol 2
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591090
[Journal Article] Involvement of accumulated endogenous NOS inhibitors and accelerated arginase activity in impairing the NO production in pulmonary arterial hypertension of the Rat.2005
- Author(s)
  Sasaki A, Doi S, Wakimoto H, Takahashi R, Azuma H.
- Journal Title
  
  American Journal of Respiratory and Critical Care Medicine 171(7)
- Data Source
  KAKENHI-PROJECT-15591090
[Journal Article] Mediators involved in decreasing peripheral vascular resistance with carbachol in the rat hind limb perfusion model.2005
- Author(s)
  Loyaga-Rendon RY, Sakamoto S, Aso T, Iwasaki-Kurashige, Takahashi R, Azuma H.
- Journal Title
  
  Journal of Pharmacological Science (in press)
- NAID
  10025728953
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572152
[Journal Article] Involvement of accumulated endogenous NOS inhibitors and accelerated arginase activity in impairing the NO production in pulmonary arterial hypertension of the rat2005
- Author(s)
  Sasaki A, Doi S, Wakimoto H, Takahashi R, Azuma H
- Journal Title
  
  American Thoracic Society 2005 San Diego International Conference Abstracts Issue Volume 2
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591090
[Journal Article] Accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, attenuated dimethylarginine dimethylaminohydrolase activity and intimal hyperplasia in premenopausal human uterine arteries2005
- Author(s)
  Loyaga-Rendon RY, Sakamoto S, Beppu M, Aso T, Ishizaka M, Takahashi R, Azuma H.
- Journal Title
  
  Atherosclerosis 178
  
  Pages: 231-239
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572152
[Journal Article] Involvement of increased arginase activity in the impaired cavernosal relaxation with aging in the rabbit2004
- Author(s)
  Sakai Y, Masuda H, Kihara K, Kurosaki E., Yamauchi Y, Azuma H
- Journal Title
  
  Journal of Pharmacological Sciencee 94(Suppl I)
  
  Pages: 182-182
- Data Source
  KAKENHI-PROJECT-14572152
[Journal Article] Modulation of NO production by arginase in the rabbit lower urinary tract2004
- Author(s)
  Yano M, Masuda H, Kawano K, Sakai Y, Kihara K, Azuma H
- Journal Title
  
  Journal of Pharmacological Science 94(Suppl I)
  
  Pages: 264-264
- Data Source
  KAKENHI-PROJECT-14572152
[Journal Article] Roles of endogenous NOS inhibitors and endothelin-1 for regulating myometrial contractions during gestation of the rat.2004
- Author(s)
  Momohara Y, Sakamoto S, Obayashi S, Aso T, Ooto M, Azuma H.
- Journal Title
  
  Molecular Human Reproduction 10
  
  Pages: 505-512
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572152
[Journal Article] Possible involvement of facilitated polyol pathway in augmentation of intimal hyperplasia in rabbits with alloxan-induced hyperglycemia2003
- Author(s)
  Goto M, Yamauchi Y, Kurosaki E, Azuma H.
- Journal Title
  
  Journal of Cardiovascular Pharmacology 41
  
  Pages: 265-227
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572152
[Journal Article] Possible involvement of facilitated polyol pathway in augmentation of intimal hyperplasia in rabbits with alloxan-induced hyperglycemia.2003
- Author(s)
  Goto M, Yamauchi Y, Kurosaki E, Azuma H.
- Journal Title
  
  Journal of Cardiovascular Pharmacology 41
  
  Pages: 265-275
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572152
[Journal Article] Changes in the responsiveness of peripheral resistant vessels during pregnancy of the rat.2002
- Author(s)
  R.Loyaga, S.Sakamoto, T.Aso, Y.Yamauchi, H.Azuma
- Journal Title
  
  Proceedings of 54^th Annual Congress of the Japan Society of Obstetrics and Gynecology
  
  Pages: 39-44
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13671700
[Journal Article] Changes in the responsiveness of peripheral resistant vessels during pregnancy of the rat2002
- Author(s)
  R.Loyaga, S.Sakamoto, T.Aso, Y.Yamauchi, H.Azuma
- Journal Title
  
  Proceedings of 54^<th> Annual Congress of the Japan Society of Obstetrics and Gynecology
  
  Pages: 39-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13671700

1. DOI Shouzaburou (80262195)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. OBAYASHI Satoshi (10262180)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
3. TSUJII Toshihiko (90217307)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. ISOTANI Eiji (90251529)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. ASO Takeshi (60093176)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. KUBOTA Toshiro (50126223)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KAGEYAMA Yukio (10211153)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. WAKIMOTO Hiroko (60345296)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. ISHIZAKA Kazuhiro (60168218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KITAHARA Satoshi (10186257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KIHARA Kazunori (40161541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MORITA Takashi (10006819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MASUDA Hitoshi (80301167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. SAKAMOTO Shuichi (90242198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. FURUKAWA Tetsushi (80251552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 今村公俊 (40422472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 佐々木章人 (20328454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 己斐秀樹 (20280969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 増田均 (60323680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 鈴木龍太

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AZUMA Hiroshi 東 洋

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Acceleration of intinul hyperplasia by the enhanced arginase activity due to hyperglycemiaPrincipal Investigator

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Possible involvement of facilitated aldose reductase activity in the accelerated vascular remodeling in rabbits with alloxan-induced hyperglycemiaPrincipal Investigator

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Regulation of NOS activity by the endogenous inhibitors and modification of hyperplastic vascular diseases with the inhibitors.Principal Investigator

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[Journal Article] Accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity attenuated dimethylarginine dimethylaminohydrolase activity and2005

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[Journal Article] Involvement of accumulated endogenous NOS inhibitors and accelerated arginase activity in impairing the NO production in pulmonary arterial hypertension of the rat.2005

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[Journal Article] Involvement of accumulated endogenous NOS inhibitors and accelerated arginase activity in impairing the NO production in pulmonary arterial hypertension of the Rat.2005

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AZUMA Hiroshi 東洋