MURAKAMI Teruo 村上照夫

Researcher Number	20136055
Other IDs
Affiliation (based on the past Project Information) *help	2010 – 2015: 広島国際大学, 薬学部, 教授 2006 – 2007: 広島国際大学, 薬学部, 教授 2002: Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 1996 – 2001: 広島大学, 医学部, 助教授 1991 – 1994: 広島大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Medical pharmacy / Environmental pharmacy / Biological pharmacy / Physical pharmacy / Science and Engineering Except Principal Investigator Biological pharmacy / Medical pharmacy / Physical pharmacy
Keywords	Principal Investigator ABCトランスポーター / Caco-2 / MRP2 / ABC transporter / P-glycoprotein / LLC-GA5-COL150 / 内分泌撹乱物質 / チトクロームP-450 / P-糖蛋白質 / ゲニステイン … More / natural products / pharmacokinetics / isoflavone / flavone / reversing agent for multidrug resistance / リポソーム / BCRP / MRP / 多剤耐性 / リボソーム / DDS / 薬物動態解析 / 天然植物成分 / 薬物動態 / P-糖タンパク質 / イソフラボン / フラボン / 多剤耐性克服剤 / host defense mechanism / cytochrome P450 3A / genistein / endocrine disruptor / 誘導 / di-2-ethylhexyl phthalate / 生体防御 / ステロイドホルモン / トリブチルスズ / タモキシフェン / エストラジオール / チトクロームP4503A / 内分泌かく乱物質 / 生体防御機構 / チトクーロームP-450 / Kinetic Analysis / Cerebrospinal Fluids Distribution / Brain Distribution / Recovery Percent / Caffeine / Cerebrospinal Fluid / Brain / Microdialysis / 速度論的解析 / 脳脊髄液分布 / 脳分布 / 回収率 / カフェイン / 脳脊髄液 / 脳 / マイクロダイアリシス / 経皮適用製剤 / イトラコナゾール / グリセオフルビン / 難水溶性薬物 / 溶解補助剤 / 大環状構造 / 生体膜透過 / 生物薬剤学的応用 / 包接化合物 / 両親媒性包接化合物 / サイクリックビスビスデスモシド / シクロデキストリン / 吸収改善 / 溶解度改善 / 包接複合体 / 難水溶性化合物 / サイクリックビスデスモシド / 植物エストロゲン … More Except Principal Investigator ClC-5 / 培養腎上皮細胞 / エンドサイトーシス / 腎尿細管 / renal tubules / receptor / hypercalciuria / proteinuria / endocytosis / chloride channel / Dent's disease / 遺伝性腎疾患 / 蛋白尿 / エンドソーム内酸性化 / 高カルシウム尿症 / レセプター / 高カルシウム尿 / タンパク尿 / クロライドチャネル / デント病 / endocrine disrupting chemical / multidrug resistance / estrogen / corticosterone / endogenous inhibitor / hepatic failure / renal failure / P-glycoprotein / 内因性物質 / ローダミン123 / 内分泌かく乱物質 / エストロゲン / コルチコステロン / 多剤耐性 / 内因性阻害物質 / 肝障害 / 腎障害 / P-糖蛋白質 / Guinea-pigs / Rabbits / Mice / Rats / Phosphatidylserine / Weakly basic drugs / Quinidine / Tissue distribution / ヒトでの分布予測 / アニマルスケールアップ / 相互作用 / 種差 / ホスファチジルセリン含量 / 塩基性薬物 / フォスファチジルセリン / モルモット / 家兎 / マウス / ラット / フオスファチジルセリン / 弱塩基性薬物 / キニジン / 組織分布 / Mrp2 / P-gp / 異物排出ポンプ / 妊娠 / 医療薬剤学 / アミノグリコシド / アルブミン / カルシウム結合蛋白 / メガリン / 膜流動性 / テトラエテルアンモニウム / 有機カチオン輸送系 / 刷子縁膜 / 発育 Less

Evaluation of biopharmaceutical usefulness of cyclic-bis-desmosides, an amphiphilic inclusion compoundPrincipal Investigator
- Principal Investigator
  
  Murakami Teruo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hiroshima International University
Interaction of hydrophobic components in female urine before and after childbirth with P-glycoprotein in vitro
- Principal Investigator
  
  MORI Nobuhiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hiroshima International University
Development of reversing agent for multidrug resistance and new chemotherapy by utilizing genisteinPrincipal Investigator
- Principal Investigator
  
  MURAKAMI Teruo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hiroshima International University
植物エストロゲンの体内動態と生体防御・解毒機構に及ぼす影響解析Principal Investigator
- Principal Investigator
  
  村上照夫
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  Hiroshima University
Studies on the mechanisms underlying renal tubular deficiency due to the lack of the expression and function of CLCN5, a gene responsible for Dent's disease
- Principal Investigator
  
  TAKANO Mikihisa
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY
Effect of endocrine disrupting chemicals on host defense mechanism (transpoter, enzymes)Principal Investigator
- Principal Investigator
  
  MURAKAMI Teruo
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY
Search for the new, endogenous compound with multidrug resistance modulating activity and its application to cancer chemotherapy
- Principal Investigator
  
  TAKANO Mikihisa
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
メガリン(gp330)の分子・細胞生物学的解析と新規薬物送達システム開発への応用
- Principal Investigator
  
  高野幹久
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hiroshima University
発育に伴う薬物腎排泄能変化の分子機構に関する研究
- Principal Investigator
  
  TAKANO Mikihisa
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
Study on interspecies-difference in tissue distribution of weakly basic drugs and prediction of the distribution in human
- Principal Investigator
  
  YATA Noboru
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY
Study on Drug Distribution into Brain and Cerebrospinal Fluid by MicrodialysisPrincipal Investigator
- Principal Investigator
  
  MURAKAMI Teruo
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY

All 2016 2015 2013 2012 2011 2008 2007

All Journal Article Presentation

[Journal Article] Characterization of intestinal absorp-tion of quinidine2012
- Author(s)
  Nobuhiro Mori, Haruka Iwamoto,Tomoharu Yokooji, Teruo Murakami
- Journal Title
  
  P-glycoproteinsubstrate, given as a powder in rats.Parmazie
  
  Volume: 67(5) Pages: 384-388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590162
[Journal Article] Fate of quinidine, a P-glycoprotein substrate, in the gastrointestinal tract after oral administration in rats2008
- Author(s)
  Mori N, Yokooji T, Murakami T.
- Journal Title
  
  Pharmazie 63(3)
  
  Pages: 241-244
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590162
[Journal Article] Characterization of intestinal absorption of mizoribine mediated by concentrative nucleoside transporters in rats.2008
- Author(s)
  Mori N, Yokooji T, Kamio Y, Murakami T.
- Journal Title
  
  Eur J Pharmacol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590162
[Journal Article] Site-specific bidirectional efflux of 2, 4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells.2007
- Author(s)
  Yokooji T, Murakami T, Yumoto R, Nagai J, Takano M.
- Journal Title
  
  J Pharm Pharmacol. 59(4)
  
  Pages: 513-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590162
[Journal Article] Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function.2007
- Author(s)
  Patanasethanont D, Nagai J, Yumoto R, Murakami T, Sutthanut K, Sripanidkulchai BO, Yenjai C, Takano M.
- Journal Title
  
  J Pharm Sci. 96(1)
  
  Pages: 223-233
- NAID
  120000875409
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590162
[Journal Article] Role of intestinal efflux transporters in the intestinal absorption of methotrexate in rats.2007
- Author(s)
  Yokooji T, Murakami T, Yumoto R, Nagai J, Takano M.
- Journal Title
  
  J Pharm Pharmacol. 59(9)
  
  Pages: 1263-1270
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590162
[Presentation] 難水溶性薬物の溶解・消化管吸収に及ぼす両親媒性包接化合物サイクリックビスデスモシドの影響2016
- Author(s)
  小田　啓祐、森　信博、猪山　陽輔、村上　照夫
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25460052
[Presentation] ABCトランスポーター基質の消化管吸収に及ぼすポリフェノール含有飲料水の影響2015
- Author(s)
  小田　啓祐1 、金城　拓也、石岡　朋子、山田　千晴、森　信博、村上　照夫
- Organizer
  日本薬剤学会第３０年会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460052
[Presentation] Modulation of ABC transporter- mediated host defense and detoxify- cation mechanism by endogenous and exogenous compounds2013
- Author(s)
  村上照夫、横大路智治、森信博
- Organizer
  9th Retrometabolism Based DrugDesign and Targeting Conference
- Year and Date
  2013-05-14
- Data Source
  KAKENHI-PROJECT-22590162
[Presentation] 妊娠期・授乳期尿中の内因性物質とABCトランスポーターとの相互作用解析2012
- Author(s)
  亀田祐希、横大路智治、森信博、村上照夫
- Organizer
  第51回日本薬学会日本病院薬剤師会
- Place of Presentation
  中国四国支部学術大会
- Year and Date
  2012-11-11
- Data Source
  KAKENHI-PROJECT-22590162
[Presentation] Characterization of intestinalabsorption of quinidine, a Pglycoproteinsubstrate2011
- Author(s)
  森信博、横大路智治、岩元陽香、村上照夫
- Organizer
  日本薬物動態学会第26回年会
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-22590162
[Presentation] Transporter-mediated intestinal absorption and secretion of immunosuppressants2008
- Author(s)
  Murakami T
- Organizer
  Curative workshop for refractory nephrotic syndrome
- Place of Presentation
  Tokyo
- Year and Date
  2008-01-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590162
[Presentation] 免疫抑制剤のトランスポーター介在性消化管吸収・分泌挙動2008
- Author(s)
  村上照夫
- Organizer
  難治性ネフローゼ症候群治療研究会
- Place of Presentation
  東京
- Year and Date
  2008-01-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590162
[Presentation] Participation of efflux transporters in the intestinal drug absorption.2007
- Author(s)
  Murakami T, Yokooji T, Mori N.
- Organizer
  Retrometabolism based drug design and targeting 6th Conference
- Place of Presentation
  Hungary
- Year and Date
  2007-07-04
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590162
[Presentation] Participation of efflux transporters in the intestinal drug absorption2007
- Author(s)
  Teruo Murakami
- Organizer
  6th Retrometabolism based Drug Design and Targeting Conference
- Place of Presentation
  Hungary
- Year and Date
  2007-06-04
- Data Source
  KAKENHI-PROJECT-18590162
[Presentation] Participation of efflux transporters in the intestinal drug absorption2007
- Author(s)
  Murakami T
- Organizer
  Retrometabolism based drug design and targeting 6th conference
- Place of Presentation
  Hungary
- Year and Date
  2007-06-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590162

1. TAKANO Mikihisa (20211336)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. NAGAI Junya (20301301)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MORI Nobuhiro (70412351)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
4. YOKOOJI Tomoharu (70389120)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
5. HIGASHI Yutaka (90127697)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ODA Keisuke (60712594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. YATA Noboru (70028835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. UNE Mizuho (20144826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 堂官留美子 (20435069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 金子哲夫 (00389107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 笠井良次 (10034018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MURAKAMI Teruo 村上 照夫

Research Projects

Research Products

Co-Researchers

Evaluation of biopharmaceutical usefulness of cyclic-bis-desmosides, an amphiphilic inclusion compoundPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interaction of hydrophobic components in female urine before and after childbirth with P-glycoprotein in vitro

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of reversing agent for multidrug resistance and new chemotherapy by utilizing genisteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

植物エストロゲンの体内動態と生体防御・解毒機構に及ぼす影響解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on the mechanisms underlying renal tubular deficiency due to the lack of the expression and function of CLCN5, a gene responsible for Dent's disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of endocrine disrupting chemicals on host defense mechanism (transpoter, enzymes)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for the new, endogenous compound with multidrug resistance modulating activity and its application to cancer chemotherapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

メガリン(gp330)の分子・細胞生物学的解析と新規薬物送達システム開発への応用

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

発育に伴う薬物腎排泄能変化の分子機構に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on interspecies-difference in tissue distribution of weakly basic drugs and prediction of the distribution in human

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on Drug Distribution into Brain and Cerebrospinal Fluid by MicrodialysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Characterization of intestinal absorp-tion of quinidine2012

Author(s)

Journal Title

Data Source

[Journal Article] Fate of quinidine, a P-glycoprotein substrate, in the gastrointestinal tract after oral administration in rats2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Characterization of intestinal absorption of mizoribine mediated by concentrative nucleoside transporters in rats.2008

MURAKAMI Teruo 村上照夫