SUGIMOTO Nakaba 杉本央

… Alternative Names

杉本央スギモトナカバ

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Researcher Number	20142317
Other IDs
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Affiliation (based on the past Project Information) *help	2010: Osaka University, 大学院・医学系研究科, 教授 2007 – 2010: Osaka University, 医学系研究科, 教授 1999 – 2001: Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 1999: 大阪大学, 大学院・医学系研究科, 教授 1997 – 1998: Osaka University, Res. Inst. Microb. Dis., Bact. Tox., Assoc. Prof., 微生物研究所, 助教授 … More 1992 – 1998: 大阪大学, 微生物病研究所, 助教授 1990: 大阪大学, 微生物病研究所, 助教授 1986: Research Institute for Microbial Diseases, Osaka University, 微生物病研究所, 助手 Less
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / 細菌学 Except Principal Investigator Bacteriology (including Mycology) / 細菌学
Keywords	Principal Investigator ウエルシュ菌 / θ毒素 / EDRF / ヒト型モノクローナル抗体 / ジフテリア / ハイブリドーマ / 抗毒素 / ボツリヌス中毒症 / 破傷風 / 血管内皮細胞 … More / ボツリヌス菌 / NO / チオール活性化溶血素 / 細菌毒素 / エンテロトキシン / neutralization / perfusion culture / hybridoma / tetanus anti-toxin / human monoclonal antibody / ボツリヌス毒素 / 連続培養 / bacterial protein toxin / ERDF / endothelium / ex vivo perfusion / renal clearance / acute renal failure / gas gangrene / C.perfringens / パラアミノ馬尿酸 / イヌリン / クリアランス機能 / 細菌性チオ-ル活性化溶血素 / ガス壊疸 / 腎不全 / ガス壊疽 / toxoid / myeloma / antitoxin / botulinun neurotoxin / human IgG / monoclonal antibody / tetanus / ヒト型抗毒素モノクローナル抗体 / トキソイド / ミエローマ / ヒト型モノクロナール抗体 / ARDS / vascular contractility / endothelial cell / theta toxin / botulinolysin / Clostridium pefringens / Clostridium botulinum / 成人呼吸促迫症候群 / 血管収縮性調節機構 / ボツリノリジン / Endothelial cells / Vascular contractility / Thiol-activated hemolysin / bacterial toxin / 内皮細胞 / 血管収縮性 / 嘔吐運動 / パターンジェネレーター / 消化管蠕動運動 / ブドウ球菌 / 食中毒 / 感染免疫 / 肝障害 / 膜障害 / 高カリウム血症 / 致死機序 / 蛋白毒素 … More Except Principal Investigator 毒素フラグメント / 破傷風毒素 / Toxin fragment / Tetanus toxin / テタノリジン / カルモデュリン / プロティンキナーゼC / クロマフィン細胞 / 開口分泌 / 細胞内局在 / Tetanus / Tetanus intoxication / 自律神経系活動異常 / 致死原因 / 自律神経系 / 破傷風 / 破傷風中毒症 / Toxic action / Cytotoxicity / Recombined toxin fragments / Diphtheria toxin / ヒトモノクロナール抗体 / 毒作用 / 細胞毒性 / キメラ毒素 / ジフテリア毒素 / Amino acid sequences of variable regions / Molecular cloning of variable region genes / Toxin-neutralizing antibody / Antitoxin applicable to humans / Human monoclonal antibody / Tetanus antitoxin / 可変部アミノ酸配列 / 可変部遺伝子のクローニング / 毒素中和抗体 / 抗毒素の実用化 / ヒトモノクローナル抗体 / 破傷風抗毒素 / 国際会議 / 治療法 / 病原因子 / クロストリジウム / C-キナーゼ / 副腎クロマフィン細胞 / 神経伝達物質 Less

Pathophysiological analysis of the emesis induced by Staphyrococcal enterotoxinPrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Nakaba
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka University
クロストリジュウムの病原性に関する第3回国際会議
- Principal Investigator
  
  林英生
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  University of Tsukuba
Establishment of a mass production system of human monoclonal anti-toxin antibodiesPrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Nakaba
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka University
Study on roles of α and θ toxins in the pathogenesis of the acute renal failure in gas gangrene of Clostridium perfringensPrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Nakaba
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka University
Development of human anti-toxin monoclonal antibodiesPrincipal Investigator
- Principal Investigator
  
  SUGMOTO Nakaba
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka University
Analysis of physiological functions of target proteins of tetanus and diphtheria toxins using complexes of homologous fragments of the toxins
- Principal Investigator
  
  MATSUDA Morihiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Koshien University
  Osaka University
Studies on the action of bacterial thiol-activated hemolysins on endothelial cells of pulmonary circulation.Principal Investigator
- Principal Investigator
  
  SUGIMOTO Nakaba
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka University
Studies on the application of anti-tetanus human monoclonal antibodies having high neutralizing activity to use in place of current polyclonal tetanus antitoxin preparations.
- Principal Investigator
  
  MATSUDA Morihiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka Unviresity
Study on the cardiotoxic actions of botulinolysin and other bacterial thiol-activated hemolysins.Principal Investigator
- Principal Investigator
  
  SUGIMOTO Nakaba
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka University
活性毒素フラグメント[A]を用いた破傷風毒素の神経伝達阻害作用の分子機構解明
- Principal Investigator
  
  MATSUDA Morihiro
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  Osaka University
活性毒素フラグメント〔A〕を用いた破傷風毒素の神経伝達阻害作用の分子機構の解明
- Principal Investigator
  
  松田守弘
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Institution
  Osaka University
ウエルシュ菌エンテロトキシンの静脈内注射による動物の致死機序の解析Principal Investigator
- Principal Investigator
  
  杉本央
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Osaka University
Analyses, using toxin fragment, of disturbances in autonomic nervous system in tetanus intoxication, a possible major cause of tetanus death
- Principal Investigator
  
  MATSUDA Morihiro
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  Osaka University

All 2011 2010 2009 2008 2007

All Journal Article

[Journal Article] Comparison of effects of botuhnum toxin subtyoe A1 and A2 using twitch tension assay and rat grip strength test.2011
- Author(s)
  鳥居恭司、杉本央
- Journal Title
  
  Toxicon
  
  Volume: 57 Pages: 93-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Comparison of effects of botulinum toxin subtyoe A1 and A2 using twitch tension assay and rat grip strength test.2011
- Author(s)
  Torii, Y., N. Kiyota, N. Sugimoto, Y. Mori, Y. Goto, T. Harakawa, S. Nakahira, R. Kaji, S. Kozaki, A. Ginnaga
- Journal Title
  
  Toxicon 57
  
  Pages: 93-99
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Activation of motility by sensing short-chain fatty acids via two steps in a glagellar gene regulatory cascade in enterohemorrhagic Escherichia coli.2010
- Author(s)
  Tobe, T., N. Nakanishi, N. Sugimoto
- Journal Title
  
  Infection and Immunity 79
  
  Pages: 1016-1024
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] NleC, a type III secretion protease, compromises NF-kB activation by targeting p65/RelA.2010
- Author(s)
  Yen, H., T. Ooka, A. Iguchi, T, Hayashi, N. Sugimoto, T. Tobe
- Journal Title
  
  PloS athogens 6(12)
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] PCR with quenching probes enables the rapid detection and identification of ganciclovir-resistance causing U69 gene mutations in human herpesvirus 6.2010
- Author(s)
  伊勢川裕二、杉本央
- Journal Title
  
  Molecular and Cellular Probes
  
  Volume: 24 Pages: 167-177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] NIeC, a type III secretion protease, compromises NF-kB activation by targeting p65/RelA.2010
- Author(s)
  顔宏哲、杉本央
- Journal Title
  
  PloS Pathogens
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Activation of motility by sensing short chain fatty acids via two stepsin a glagellar gene regulatory cascade in enterohemorrhagic Escherichiacoli.2010
- Author(s)
  戸邉亨、杉本央
- Journal Title
  
  Infection and Immunity
  
  Volume: 79 Pages: 1010-1020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] PCR with quenching probes enables the rapid detection and identification of ganciclovir-resistance causing U69 gene mutations in human herpesvirus 6.2010
- Author(s)
  Isegawa, Y., C. Matsumoto, K. Nishinaka, K. Nakano, N. Sugimoto, A. Oshima
- Journal Title
  
  Molecular and Cellular Probes 24
  
  Pages: 167-177
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Enterohemorrhagic Escherichia coli effector EspL2 induces actin microfilament aggregation through annexin 2 activation2009
- Author(s)
  A. Miyahara, N. Nakanishi, T. Ooka, T. Hayashi, N. Sugimoto, T. Tobe
- Journal Title
  
  Cellular Microbiology 11, 2
  
  Pages: 337-350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Enterohemorrhagic Escherichia coli effector EspL2 induces actin microfilament aggregation through annexin 2 activation.2009
- Author(s)
  A. Miyahara, N. Nakanishi, T. Ooka, T. Hayashi, N. Sugimoto, T. Tobe
- Journal Title
  
  Cellular Microbiology 11, 2
  
  Pages: 337-350
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Detection and identification of U69 gene mutations encoded by ganciclovir-resistant human herpesvirus 6 using denaturing high-performance liquid chromatography2009
- Author(s)
  Kazushi Nakano, Kazuko Nishinaka, Tatsuya Tanaka, Atsushi Ohshima, Nakaba Sugimoto, Yuji Isegawa
- Journal Title
  
  Journal of Virological Methods 161
  
  Pages: 223-230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Enterohemorrhagic Escherichia coli effector EspL2 induces actin microfilament aggregation through annexin 2 activation2009
- Author(s)
  A.Miyahara, N.Nakanishi, T.Ooka, T.Hayashi, N.Sugimoto, T.Tobe
- Journal Title
  
  Cellular Microbiology 11
  
  Pages: 337-350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Regulation of virulence by butyrate sensing in enterohaemorrhagic Escherichia coli2009
- Author(s)
  N. Nakanishi, K. Tashiro, S. Kuhara, T. Hayashi, N. Sugimoto, T. Tobe
- Journal Title
  
  Microbiology 155, 2
  
  Pages: 521-530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Regulation of virulence by butyrate sensing in entero-haemorrhagic Escherichia coli2009
- Author(s)
  N.Nakanishi, K.Tashiro, S.Kuhara, T.Hayashi, N.Sugimoto, T.Tobe
- Journal Title
  
  Microbiology 155
  
  Pages: 521-530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Detection and identification of U69 gene mutations encoded by ganciclovir-resistant human herpesvirus 6 using denaturing high-performance liquid chromatography.2009
- Author(s)
  Kazushi Nakano, Kazuko Nishinaka, Tatsuya Tanaka, Atsushi Ohshima, Nakaba Sugimoto, Yuji Isegawa
- Journal Title
  
  Journal of Virological Methods 161
  
  Pages: 223-230
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Regulation of virulence by butyrate sensing in enterohaemorrhagic Escherichia coli.2009
- Author(s)
  N. Nakanishi, K. Tashiro, S. Kuhara, T. Hayashi, N. Sugimoto, T. Tobe
- Journal Title
  
  Microbiology 155, 2
  
  Pages: 521-530
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Characterization of the human herpesuvirus 6 U69 gene product and identification of its nuclear localization signal.2008
- Author(s)
  Yuji Isegawa, Yoichi Miyamoto, Yoshinari Yasuda, Katsunori Semi, Kenji Tsujimura, Rikiro Fukunaga, Atsushi Ohshima, Yasuhiro Horiguchi, Yoshihiro Yoneda, Nakaba Sugimoto
- Journal Title
  
  Journal of Virology 82, No.2
  
  Pages: 710-718
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Characterization of the human herpesuvirus 6 U69 gene product and identification of its nuclear localization signal2008
- Author(s)
  Yuji Isegawa, Yoichi Miyamoto, Yoshinari Yasuda, Katsunori Semi, Kenji Tsujimura, Rikiro Fukunaga, Atsushi Ohshima, Yasuhiro Horiguchi, Yoshihiro Yoneda, Nakaba Sugimoto
- Journal Title
  
  Journal of Virology 82, No. 2
  
  Pages: 710-718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Reactivation of latent human immunodeficiency virus 1 by human herpesvirus 6 infection.2007
- Author(s)
  Y. Isegawa, J. Katahira, K. Yamanishi, N. Sugimoto
- Journal Title
  
  Acta Virologica 51
  
  Pages: 13-20
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Maturation of functional type III secretion machinery by activation of anaerobic respiration in enterohaemorrhagic Escherichia coli.2007
- Author(s)
  Hiroki Ando, Hiroyuki Abe, N.Sugimoto, Toru Tobe
- Journal Title
  
  Microbiology 153
  
  Pages: 464-473
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Maturation of functional type III secretion machinery by activation of anaerobic respiration in enterohaemorrhagic Escherichia coli2007
- Author(s)
  Hiroki Ando, Hiroyuki Abe, Nakaba Sugimoto, Toru Tobe
- Journal Title
  
  Microbiology 153
  
  Pages: 464-473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590444
[Journal Article] Real-time PCR determination of human herpes virus 6 antiviral drug susceptibility.2007
- Author(s)
  Yuji Isegawa, Masaya Takemoto, Koichi Yamanishi, Atsushi Ohshima, Nakaba Sugimoto
- Journal Title
  
  Journal of Virological Methods 140
  
  Pages: 25-31
- Data Source
  KAKENHI-PROJECT-19590444

1. MATSUDA Morihiro (20029771)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. HORIGUCHI Yasuhiko (00183939)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KOZAKI Shunji (10109895)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KATAHIRA Jun (30263312)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKAHASHI Motohide (00216764)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 岡部登志男 (80204014)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. HASHIZUME Shuichi

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OGUMA Keiji (00002262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUGIMOTO Hisashi (90127241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OZUTSUMI Kunihiro (00144519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HIRAI Toshihiro (50029790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 林英生 (40033203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 渡邊邦友 (70108067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 神谷茂 (10177587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 清水徹 (80235655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 雷殿良

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 孟筱埼

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. XIAOQI Meng

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. DIANLIANG Lei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SUGIMOTO Nakaba 杉本 央

杉本 央 スギモト ナカバ

Research Projects

Research Products

Co-Researchers

Pathophysiological analysis of the emesis induced by Staphyrococcal enterotoxinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

クロストリジュウムの病原性に関する第3回国際会議

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of a mass production system of human monoclonal anti-toxin antibodiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on roles of α and θ toxins in the pathogenesis of the acute renal failure in gas gangrene of Clostridium perfringensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of human anti-toxin monoclonal antibodiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of physiological functions of target proteins of tetanus and diphtheria toxins using complexes of homologous fragments of the toxins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the action of bacterial thiol-activated hemolysins on endothelial cells of pulmonary circulation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the application of anti-tetanus human monoclonal antibodies having high neutralizing activity to use in place of current polyclonal tetanus antitoxin preparations.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the cardiotoxic actions of botulinolysin and other bacterial thiol-activated hemolysins.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

活性毒素フラグメント[A]を用いた破傷風毒素の神経伝達阻害作用の分子機構解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

活性毒素フラグメント〔A〕を用いた破傷風毒素の神経伝達阻害作用の分子機構の解明

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ウエルシュ菌エンテロトキシンの静脈内注射による動物の致死機序の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses, using toxin fragment, of disturbances in autonomic nervous system in tetanus intoxication, a possible major cause of tetanus death

Principal Investigator

Project Period (FY)

Research Category

SUGIMOTO Nakaba 杉本央

杉本央スギモトナカバ