Matsuura Motohiro 松浦基博

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MATSUURA Motohiro 松浦基博

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Researcher Number	20150089
Other IDs
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Affiliation (Current)	2025: 京都大学, 医学研究科, 非常勤講師
Affiliation (based on the past Project Information) *help	2012 – 2014: 京都大学, 医学(系)研究科(研究院), 非常勤講師 2001 – 2006: 自治医科大学, 医学部, 助教授 1997 – 1998: 自治医科大学, 医学部, 助教授 1991 – 1994: 自治医科大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / 細菌学 Except Principal Investigator 細菌学 / Bacteriology (including Mycology) / Immunology
Keywords	Principal Investigator エンドトキシン / IL-18 / IL-12 / Endotoxin / IL-6 / TNF / LPS / リポ多糖(LPS) / 腫瘍壊死因子(TNF) / 合成リピドA類縁化合物 … More / エンドトキシントレランス / エンドトキシンショック / LPS antagonist / regulation of IL-12 expression / endotoxin / lipopolysaccharide (LPS) / LPSアンタゴニスト / IL-12発現調節 / 内毒素 / 細菌リポ多糖(LPS) / Nitric oxide / Interferon-γ / Lipopolysaccharidc / 一酸化窒素 / インターフェロン-γ / 細菌リポ多糖 / Human macrophages / Lipid A / Lipopolysaccharide / TNF-α / リボ多糖 / ヒトマクロファージ / リピドA / リポ多糖 / TLR4 / 免疫回避 / 細菌感染 / 自然免疫 / 細菌リポ多糖LPS / 細菌内毒素 / リポポリサッカライド … More Except Principal Investigator Microcystin / gamma-linolenic acid / Microcystis aeruginosa / Clonine / Acyl transferase / Pathogenicity / Growth temperature / Chemical structure / Lipid A / Endotoxin / Yersinia pestis / マクロファージ活性化 / コア糖鎖 / 発現調節 / 培養温度 / クローニング / 脂肪酸転移酵素 / 病原性 / 生育温度 / 化学構造 / リピドA / エンドトキシン / ペスト菌 / HIV-6 / Component vaccine of influenza virus / Hanta virus / Synthetic DNA / Lipid A derivatives / Artificial polysaccharide immunoadjuvants / Microbial-derived immunomodulators / Muramyldipeptide derivatives / ヒトヘルペスウイルス6 / インフルエンザコンポーネントワクチン / ハンタウイルス / 合成DNA / リピドA誘導体 / 人工多糖アジュバント / 微生物由来免疫調節剤 / ムラミルジペプチド誘導体 / monoclonal antibody / Interleukin-6 / culture method / antibacterial substance / Cyanobacteria / ミクロキスチン / 腫瘍壊死因子 / 凍結保存法 / ミクロキスチス / γ-linolenic acid / モノクローナル抗体 / インターロイキン6 / 培養法 / 抗菌活性物質 / ミクロシスチン / シアノバクテリア / Monokine / Salmonella / Legionella / Plastin / Protein Phosphorylation / Macrophages / Bacterial Lipopolysaccharide (LPS) / Bacterial Infection / Lーアルギニン / マクロファ-ジ / 緑膿菌 / 腫瘍壊死因子(TNF) / モノカイン / サルモネラ / レジオネラ / プラスチン / 蛋白リン酸化 / マクロファージ / 細菌リポ多糖(LPS) / 細菌感染 Less

Role of structural alteration of bacterial lipopolysaccharide on bacterial evasion of host innate immune responsesPrincipal Investigator
- Principal Investigator
  
  MATSUURA Motohiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto University
Mechanisms for regulation of excessive host responses to LPSPrincipal Investigator
- Principal Investigator
  
  MATSUURA Motohiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Jichi Medical University
Chemical structure of Yersinia pestis endotoxin and its role in the infection
- Principal Investigator
  
  KAWAHARA Kazuyoshi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kanto Gakuin University
  Kitasato Institute
Endogenous interferon-γ induced by bacterial lipopolysaccbaride ; its production mechanism and roles as a mediatorPrincipal Investigator
- Principal Investigator
  
  MATSUURA Motohiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Jichi Medical School
Studies on regulatory mechanisms of LPS signal transductions in human cells.Principal Investigator
- Principal Investigator
  
  MATSUURA Motohiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Jichi Medical School
エンドトキシンショックの抑制機構に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  松浦基博
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Jichi Medical University
内毒素の素性に対するトレランス誘導機構の分子生物学的研究Principal Investigator
- Principal Investigator
  
  松浦基博
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Jichi Medical University
Immunopotentiation by immunoadjuvants of human viral vaccines
- Principal Investigator
  
  AZUMA Ichiro
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Immunology
- Research Institution
  (Institute of Immunological Science) Hokkaido University
Molecular biology on murine macrophage activated by bacterial infection or bacterial components
- Principal Investigator
  
  NAKANO Masayasu
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  Jichi Medical School
Gross culture system for cyanobacteria & its application for medication
- Principal Investigator
  
  NAKANO Masayasu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  Jichi Medical School

All 2016 2013 2012 2005 2003 2002 Other

All Journal Article Presentation Book

[Book] エンドトキシン・自然免疫研究2016
- Author(s)
  松浦基博（編集：長岡功他）
- Publisher
  医学図書出版株式会社
- Data Source
  KAKENHI-PROJECT-24590523
[Book] エンドトキシン研究6 ペスト菌LPSの培養温度による構造変化とその病原性発現における意義(編集:日本エンドトキシン研究会、楠本正一、小玉正智、谷徹)2003
- Author(s)
  川原一芳, 塚野尋子, 渡辺治雄, Buko Lindner, Otto Holst, 松浦基博
- Publisher
  医学図書出版株式会社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570255
[Journal Article] Structural modification of bacterial lipopolysaccharide that facilitate Gram-negative bacteria evasion of host innate immunity2013
- Author(s)
  Motohiro Matsuura
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 4 Pages: 1-9
- DOI
  10.3389/fimmu.2013.00109
- NAID
  120005333787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590523
[Journal Article] Listeria monocytogenes strain-specific impairment of the TetR regulator underlies the drastic increase in cyclic di-AMP secretion and beta interferon-inducing ability2012
- Author(s)
  Yamamoto T, Hara H, Tsuchiya K, Sakai S, Fang R, Matsuura M, Nomura T, Sato F, Mitsuyama M, Kawamura I
- Journal Title
  
  Infect Immun
  
  Volume: 80 Issue: 7 Pages: 2323-2332
- DOI
  10.1128/iai.06162-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390082, KAKENHI-PROJECT-23590504, KAKENHI-PROJECT-24590523, KAKENHI-PROJECT-24590524, KAKENHI-PROJECT-24659196
[Journal Article] Evasion of human innate immunity without antagonizing TLR4 by mutant Salmonella enterica serovar Typhimurium having penta-acylated lipid A2012
- Author(s)
  M. Matsuura, K. Kawasaki, K. Kawahara and M. Mitsuyama
- Journal Title
  
  Innate Immunity
  
  Volume: 18 Issue: 5 Pages: 764-773
- DOI
  10.1177/1753425912440599
- NAID
  120005398390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590523
[Journal Article] ERK1/2経路の過剰活性化によるLPS誘導IL-12p40の抑制調節機構2005
- Author(s)
  斎藤慎二, 松浦基博, 平井義一
- Journal Title
  
  第52回毒素シンポジウム予稿集(ISSN-1334-934) 52
  
  Pages: 140-145
- Data Source
  KAKENHI-PROJECT-17590397
[Journal Article] Modification of the structure of Yersinia pestis LPS by growth temperature and its significance for the expression of the pathogenicity2003
- Author(s)
  K.Kawahara, H.Tsukano, H.Watanabe, B.Lindner, O.Holst, M.Matsuura
- Journal Title
  
  Endotoxin Research 6(Eds : S.Kusumoto, M.Kodama, T.Tani, Japan Endotoxin Society)(Igaku Tosho Shuppan Co.)
  
  Pages: 60-71
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570255
[Journal Article] Modification of the structure and activity of lipid A in Yersinia pestis lipopolysaccharide by growth temperature2002
- Author(s)
  K.Kawahara, H.Tsukano, H.Watanabe, B.Lindner, M.Matsuura
- Journal Title
  
  Infection and Immunity 70
  
  Pages: 4092-4098
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570255
[Presentation] Modification of lipid A structure in lipopolysaccharide of Yersinia pestis that fasilitate bacterial evasion of human innate immunity2013
- Author(s)
  Motohiro Matsuura
- Organizer
  Cold Spring Harbor Asia Conferences, Yersinia 11 - the 11th international symposium on Yersinia
- Place of Presentation
  中国、蘇州市
- Invited
- Data Source
  KAKENHI-PROJECT-24590523
[Presentation] Evasion of human innate immunity without antagonizing TLR4 by mutant Salmonella enterica serovar Typhimurium having penta-acylated lipid A2012
- Author(s)
  M. Matsuura, K. Kawasaki, K. Kawahara and M. Mitsuyama
- Organizer
  European Congress of Immunology
- Place of Presentation
  Scottish Exhibition & Conference Centre (Glasgow, England)
- Data Source
  KAKENHI-PROJECT-24590523
[Presentation] リピドＡアシル基数減少がグラム陰性菌の病原性増強に果たす役割
- Author(s)
  松浦基博
- Organizer
  第２０回日本エンドトキシン・自然免疫研究会
- Place of Presentation
  順天堂大学本郷キャンパス
- Year and Date
  2014-12-05 – 2014-12-06
- Data Source
  KAKENHI-PROJECT-24590523

1. SAITO Shinji (50195989)

# of Collaborated Projects: 7 results

# of Collaborated Products: 1 results
2. NAKANO Masayasu (70048958)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KIRIKAE Teruo (50192563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SHIRAI Makoto (10007792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TAKI Tatuo (70049097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. AZUMA Ichiro (50028411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMANISHI Koichi (10029811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TOKURA Seiichi (40000806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ISHIZUKA Masaaki (80159722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. IKUTA Kazuyoshi (60127181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAWAHARA Kazuyoshi (20195126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 有川二郎 (10142704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 大隈邦夫

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 光山正雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Matsuura Motohiro 松浦 基博

MATSUURA Motohiro 松浦 基博

Research Projects

Research Products

Co-Researchers

Role of structural alteration of bacterial lipopolysaccharide on bacterial evasion of host innate immune responsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms for regulation of excessive host responses to LPSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemical structure of Yersinia pestis endotoxin and its role in the infection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Endogenous interferon-γ induced by bacterial lipopolysaccbaride ; its production mechanism and roles as a mediatorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on regulatory mechanisms of LPS signal transductions in human cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エンドトキシンショックの抑制機構に関する分子生物学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

内毒素の素性に対するトレランス誘導機構の分子生物学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunopotentiation by immunoadjuvants of human viral vaccines

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular biology on murine macrophage activated by bacterial infection or bacterial components

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gross culture system for cyanobacteria & its application for medication

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] エンドトキシン・自然免疫研究2016

Author(s)

Publisher

Data Source

[Book] エンドトキシン研究6 ペスト菌LPSの培養温度による構造変化とその病原性発現における意義(編集:日本エンドトキシン研究会、楠本正一、小玉正智、谷徹)2003

Author(s)

Publisher

Description

Data Source

[Journal Article] Structural modification of bacterial lipopolysaccharide that facilitate Gram-negative bacteria evasion of host innate immunity2013

Author(s)

Journal Title

DOI

NAID

Data Source

Matsuura Motohiro 松浦基博

MATSUURA Motohiro 松浦基博