YANAGIHARA Kazuyoshi 柳原五吉

… Alternative Names

柳原五吉ヤナギハラカズヨシ

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Researcher Number	20158025
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 研究所, 外来研究員
Affiliation (based on the past Project Information) *help	2018 – 2021: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 特任研究員 2017: 国立研究開発法人国立がん研究センター, その他部局等, その他 2014: 国立研究開発法人国立がん研究センター, 臨床開発センター, 研究員 2014: 国立研究開発法人国立がん研究センター, 臨床開発センター 2013: 独立行政法人国立がん研究センター, 臨床開発センター, 特任研究員 … More 2012: 独立行政法人国立がん研究センター, 早期・探索臨床研究センター, 特任研究員 2012: 独立行政法人国立がん研究センター, 臨床開発センター, 研究員 1990: 広島大学, 原爆放射能医学研究所, 助手 Less
Review Section/Research Field	Except Principal Investigator Basic Section 37010:Bio-related chemistry / Chemical biology / Human pathology / Applied pharmacology
Keywords	Except Principal Investigator 脂質 / 核酸医薬 / コンジュゲート / Lipid修飾 / コンジュゲート核酸 / エクソソーム / 免疫チェックポイント / siRNA / ナノバイオ / 生体機能利用 … More / 核酸 / バイオテクノロジー / 脂肪酸 / コンジュゲートsiRNA / RNAi効果 / 肝転移がん / in vivoでのRNAi効果 / マルチジーンサイレンシング / in vivo RNAi / マルチ遺伝子サイレンシング / 抗腫瘍効果 / DDS / RNAi / 20番染色体 / 治療 / DDX27 / 20q13 / 胃癌 / 食欲不振 / サイトカイン / グレリン / 六君子湯 / がん悪液質 / 遺伝子導入 / インタ-フェロンーγ / 腫瘍免疫 Less

Development of the immune checkpoint inhibitor using the Lipid-siRNA conjugates encapsulated with exosome
- Principal Investigator
  
  KUBO TAKANORI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Yasuda Women's University
Antitumor Effect of Lipid-Conjugated siRNA using multi-gene silencing method
- Principal Investigator
  
  Kubo Takanori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Yasuda Women's University
Screening of target genes for chromosome 20q
- Principal Investigator
  
  TSUKAMOTO Yoshiyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Oita University
Improvement of QOL for cancer patients by a traditional Japanese medicine: Ameliorative effects of cachexia by rikkunshito through ghrelin receptors
- Principal Investigator
  
  TERAWAKI Kiyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  National Cancer Center Japan
インタ-フェロンーγ遺伝子導入腫瘍細胞の免疫原性の増強機構の解析
- Principal Investigator
  
  栗林景容
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University

All 2022 2021 2020 2019 2018 2017 2016 2013 2012 2011

All Journal Article Presentation

[Journal Article] A Comparative Study of Patient-Derived Tumor Models of Pancreatic Ductal Adenocarcinoma Involving Orthotopic Implantation2022
- Author(s)
  Yanagihara Kazuyoshi、Iino Yuki、Yokozaki Hiroshi、Kubo Takanori、Oda Tatsuya、Kubo Takashi、Komatsu Masayuki、Sasaki Hiroki、Ichikawa Hitoshi、Kuwata Takeshi、Seyama Toshio、Ochiai Atsushi
- Journal Title
  
  Pathobiology
  
  Volume: 89 Issue: 4 Pages: 222-232
- DOI
  10.1159/000521714
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05703, KAKENHI-PROJECT-20K07373, KAKENHI-PROJECT-23K24172, KAKENHI-PROJECT-23K24297
[Journal Article] Sixteen Different Types of Lipid-Conjugated siRNAs Containing Saturated and Unsaturated Fatty Acids and Exhibiting Enhanced RNAi Potency.2021
- Author(s)
  Takanori Kubo , Yoshio Nishimura , Yuichiro Sato , Kazuyoshi Yanagihara , Toshio Seyama
- Journal Title
  
  ACS chemical biology
  
  Volume: 16 Pages: 150-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05703
[Journal Article] ADAR2 Regulates Malignant Behaviour of Mesothelioma Cells Independent of RNA-editing Activity.2020
- Author(s)
  Sakata KI, Maeda K, Sakurai N, Liang S, Nakazawa S, Yanagihara K, Kubo T, Yoshiyama H, Kitagawa Y, Hamada JI, Iizasa H.
- Journal Title
  
  ANTICANCER RESEARCH
  
  Volume: 40 Issue: 3 Pages: 1307-1314
- DOI
  10.21873/anticanres.14072
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21361, KAKENHI-PROJECT-19K05703, KAKENHI-PROJECT-18K07148
[Journal Article] Development and characterization of a cancer cachexia model employing a rare human duodenal neuroendocrine carcinoma-originating cell line2019
- Author(s)
  Yanagihara Kazuyoshi、Kubo Takanori、Iino Yuki、Mihara Keichiro、Morimoto Chie、Seyama Toshio、Kuwata Takeshi、Ochiai Atsushi、Yokozaki Hiroshi
- Journal Title
  
  Oncotarget
  
  Volume: 10 Issue: 25 Pages: 2435-2450
- DOI
  10.18632/oncotarget.26764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K01939, KAKENHI-PROJECT-19K05703
[Journal Article] Antitumor effect of palmitic acid‐conjugated Dsi RNA for colon cancer in a mouse subcutaneous tumor model2019
- Author(s)
  Kubo Takanori、Nishimura Yoshio、Hatori Yuta、Akagi Reiko、Mihara Keichiro、Yanagihara Kazuyoshi、Seyama Toshio
- Journal Title
  
  Chemical Biology & Drug Design
  
  Volume: 93 Issue: 4 Pages: 570-581
- DOI
  10.1111/cbdd.13454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K01939, KAKENHI-PROJECT-16K08335, KAKENHI-PROJECT-19K05703
[Journal Article] Development and biological analysis of a novel orthotopic peritoneal dissemination mouse model generated using a pancreatic ductal adenocarcinoma cell line2019
- Author(s)
  Yanagihara K, Kubo T, Mihara K, Kuwata T, Ochiai A, Seyama T, Yokozaki H
- Journal Title
  
  Pancreas
  
  Volume: 48 Issue: 3 Pages: 315-322
- DOI
  10.1097/mpa.0000000000001253
- NAID
  120006867373
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08693, KAKENHI-PROJECT-16K01939
[Journal Article] Establishment of a novel cell line from a rare human duodenal poorly differentiated neuroendocrine carcinoma2018
- Author(s)
  Yanagihara K, Kubo T, Mihara K, Kuwata T, Ochiai A, Seyama T, Yokozaki H
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 92 Pages: 36503-36514
- DOI
  10.18632/oncotarget.26367
- NAID
  120006867372
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08693, KAKENHI-PROJECT-16K01939
[Journal Article] In Vivo RNAi Efficacy of Palmitic Acid-Conjugated Dicer-Substrate siRNA in a Subcutaneous Tumor Mouse Model.2016
- Author(s)
  Kubo T, Yanagihara K, Seyama T.
- Journal Title
  
  Chem Biol Drug Des
  
  Volume: in press Issue: 6 Pages: 811-823
- DOI
  10.1111/cbdd.12720
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26870770, KAKENHI-PROJECT-16K01939
[Journal Article] Inhibitory effects of isoflavones on tumor growth and cachexia in newly established cachectic mouse models carrying human stomach cancers.2013
- Author(s)
  Yanagihara K, Takigahira M, Mihara K, Kubo T, Morimoto C, Morita Y, Terawaki K, Uezono Y
- Journal Title
  
  Nutr Cancer
  
  Volume: 65 Issue: 4 Pages: 578-89
- DOI
  10.1080/01635581.2013.776089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590510, KAKENHI-PROJECT-23590282
[Journal Article] Changes in the melancortin receptors in the hypothalamus of a rat model of cancer cachexia.2012
- Author(s)
  Suzuki M, Narita M, Ashikawa M, Furuta S, Matoba M, Sasaki H, Yanagihara K, Terawaki K, Suzuki T, Uezono Y
- Journal Title
  
  Synapse
  
  Volume: 66 (9) Issue: 8 Pages: 759-769
- DOI
  10.1002/syn.21559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590510, KAKENHI-PROJECT-24590740
[Journal Article] The sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied expression of substance P and by changes in the μ-opioid receptors in the spinal cord of mice.2012
- Author(s)
  Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashikawa M, Miyano K, Yanagihara K, Chiwaki F, Ochiya T, Suzuki T, Matoba M, Sasaki H, Uezono Y
- Journal Title
  
  Anesthesiology
  
  Volume: 117 (4) Issue: 4 Pages: 847-856
- DOI
  10.1097/aln.0b013e31826a4ac8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590510, KAKENHI-PROJECT-23390374
[Journal Article] Inhibition by pregnenolone sulphate, a metabolite of the neurosteroid pregnenolone, of voltage-gated sodium channels express- ed in Xenopus Oocytes.2012
- Author(s)
  Horishita T, Ueno S, Yanagihara N, Sudo Y, Uezono Y, Okura D, Sata T
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 120 (1) Pages: 54-58
- URL
  https://www.jstage.jst.go.jp/article/jphs/120/1/120_12106SC/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590510
[Presentation] 脂質コンジュゲートsiRNAのRNAi効果について2022
- Author(s)
  久保貴紀、西村良夫、佐藤雄一郎、柳原五吉、瀬山敏雄
- Organizer
  日本薬学会　第142年会
- Data Source
  KAKENHI-PROJECT-19K05703
[Presentation] 同所移植を用いた患者由来膵臓がんモデルの特性の比較2021
- Author(s)
  飯野由貴、柳原五吉、横崎宏、久保貴紀、久保崇、小松将之、佐々木博己、市川仁、桑田健、瀬山敏雄、落合淳志
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K05703
[Presentation] 飽和脂肪酸および不飽和脂肪酸結合型siRNAの細胞導入性とRNAi効果について2020
- Author(s)
  久保貴紀、柳原五吉、瀬山敏雄
- Organizer
  第61回日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-19K05703
[Presentation] マウス皮下腫瘍モデルに対する脂肪酸コンジュゲートDicer-substrate siRNAの抗腫瘍効果2019
- Author(s)
  久保貴紀、西村良夫、柳原五吉、瀬山敏雄
- Organizer
  第11回日本RNAi研究会
- Data Source
  KAKENHI-PROJECT-19K05703
[Presentation] 免疫チェックポイント(PD-L1)を標的とした脂肪酸結合型siRNAのRNAi効果2019
- Author(s)
  徳山美紅、久保貴紀、佐藤雄一郎、西村良夫、柳原五吉、瀬山敏雄
- Organizer
  第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-19K05703
[Presentation] In vitroおよびin vivoで高いRNAi効果を示すパルミチン酸コンジュゲートDicer-substrate siRNAの開発2019
- Author(s)
  久保貴紀、西村良夫、佐藤雄一郎、羽鳥勇太、赤木玲子、柳原五吉、瀬山敏雄
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-19K05703
[Presentation] 脂肪酸結合型siRNAを用いた免疫チェックポイント阻害剤の開発2019
- Author(s)
  中本麻美、久保貴紀、佐藤雄一郎、西村良夫、寺田美沙樹、徳山美紅、宮崎真有、柳原五吉、瀬山敏雄
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-19K05703
[Presentation] 脂肪酸コンジュゲートDicer-substrate siRNAの抗腫瘍効果2019
- Author(s)
  久保貴紀、西村良夫、柳原五吉、瀬山敏雄
- Organizer
  第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-19K05703
[Presentation] RNAi効果が高い脂肪酸結合型siRNAの開発2018
- Author(s)
  久保貴紀、西村良夫、柳原五吉、瀬山敏雄
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K01939
[Presentation] Development and biological analysis of a novel orthotopic peritoneal dissemination mouse model using newly established pancreatic cancer cell line2018
- Author(s)
  Kazuyoshi Yanagihara, Takanori Kubo, Keichiro Mihara, Takeshi Kuwata, Atsushi Ochiai, Toshio Seyama, Hiroshi Yokozaki
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K01939
[Presentation] In vitroおよびin vivoで高いRNAi効果を示す脂肪酸siRNAコンジュゲートの開発2018
- Author(s)
  久保貴紀、西村良夫、柳原五吉、瀬山敏雄
- Organizer
  日本核酸医薬学会第4回年会
- Data Source
  KAKENHI-PROJECT-16K01939
[Presentation] RNA干渉効果が高いパルミチン酸結合型Dicer-substrate siRNAの開発2017
- Author(s)
  橋本優里、久保貴紀、岩尾采未、西村良夫、平野真、柳原五吉、瀬山敏雄
- Organizer
  第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16K01939
[Presentation] 標的遺伝子の発現を効果的にノックダウンできる脂肪酸コンジュゲートsiRNAの開発2017
- Author(s)
  岩尾采未、久保貴紀、橋本優里、上藤明日香、田中一絵、西村良夫、平野真、柳原五吉、瀬山敏雄
- Organizer
  第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16K01939
[Presentation] Development of lipid-siRNA conjugates having efficient cellular uptake and a potent RNAi effect2017
- Author(s)
  Takanori Kubo, Yoshio Nishimura, Makoto Hirano, Kazuyoshi Yanagihara, Toshio Seyama
- Organizer
  The 44th International Symposium on Nucleic Acids Cemistry 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01939
[Presentation] シス型不飽和脂肪酸結合siRNAの高い細胞導入性と強い遺伝子発現抑制効果について2017
- Author(s)
  上藤明日香、久保貴紀、岩尾采未、田中一絵、橋本優里、西村良夫、平野真、柳原五吉、瀬山敏雄
- Organizer
  第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16K01939
[Presentation] 新規がん悪液質モデルラットの作製及び同モデルに対する漢方薬六君子湯の改善効果2011
- Author(s)
  寺脇潔、柳原五吉、鈴木雅美、宮野加奈子、須藤結香、白石成二、上園保仁
- Organizer
  第16回日本緩和医療学会学術大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590510
[Presentation] 胃がん悪液質マウスモデルの樹立:イソフラボンは悪液質と腫瘍増殖を阻害する2011
- Author(s)
  柳原五吉
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590510

1. Kubo Takanori (90435751)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
2. 瀬山敏雄 (90163120)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. TERAWAKI Kiyoshi (20572465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. UEZONO Yasuhito (20213340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. MATOBA Motohiro (20199904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. TSUKAMOTO Yoshiyuki (00433053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 栗林景容 (10064578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 横崎宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 坂田健一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YANAGIHARA Kazuyoshi 柳原 五吉

柳原 五吉 ヤナギハラ カズヨシ

Research Projects

Research Products

Co-Researchers

Development of the immune checkpoint inhibitor using the Lipid-siRNA conjugates encapsulated with exosome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Antitumor Effect of Lipid-Conjugated siRNA using multi-gene silencing method

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening of target genes for chromosome 20q

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement of QOL for cancer patients by a traditional Japanese medicine: Ameliorative effects of cachexia by rikkunshito through ghrelin receptors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

インタ-フェロンーγ遺伝子導入腫瘍細胞の免疫原性の増強機構の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] A Comparative Study of Patient-Derived Tumor Models of Pancreatic Ductal Adenocarcinoma Involving Orthotopic Implantation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sixteen Different Types of Lipid-Conjugated siRNAs Containing Saturated and Unsaturated Fatty Acids and Exhibiting Enhanced RNAi Potency.2021

Author(s)

Journal Title

Data Source

[Journal Article] ADAR2 Regulates Malignant Behaviour of Mesothelioma Cells Independent of RNA-editing Activity.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development and characterization of a cancer cachexia model employing a rare human duodenal neuroendocrine carcinoma-originating cell line2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antitumor effect of palmitic acid‐conjugated Dsi RNA for colon cancer in a mouse subcutaneous tumor model2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development and biological analysis of a novel orthotopic peritoneal dissemination mouse model generated using a pancreatic ductal adenocarcinoma cell line2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Establishment of a novel cell line from a rare human duodenal poorly differentiated neuroendocrine carcinoma2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] In Vivo RNAi Efficacy of Palmitic Acid-Conjugated Dicer-Substrate siRNA in a Subcutaneous Tumor Mouse Model.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibitory effects of isoflavones on tumor growth and cachexia in newly established cachectic mouse models carrying human stomach cancers.2013

Author(s)

Journal Title

DOI

Data Source

YANAGIHARA Kazuyoshi 柳原五吉

柳原五吉ヤナギハラカズヨシ