KIZAKI Masahiro 木崎昌弘

… Alternative Names

Researcher Number	20161432
Other IDs
External Links
Affiliation (Current)	2020: 埼玉医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2007 – 2017: Saitama Medical University, 医学部, 教授 2006: 慶應義塾大学, 医学部・内科学教室, 講師 2005 – 2006: 慶応大学, 医学部・内科学教室, 講師 2005 – 2006: 慶應義塾大学, 医学部, 講師 2001 – 2004: 慶應義塾大学, 医学部, 専任講師 … More
Review Section/Research Field	Principal Investigator Hematology / Hematology Except Principal Investigator Hematology / 病態科学系歯学(含放射線系歯学) / Biological pharmacy
Keywords	Principal Investigator アポトーシス / 細胞分化 / 多発性骨髄腫 / 細胞周期 / 白血病 / GM-CSF / 急性前骨髄球性白血病 / 転写因子 / NF-κB / 活性酸素 … More Except Principal Investigator TGF-β / PML-RARα / ODF / BMP / TGFβ / IL-1 / co-repressor / all-trans retinoic acid (ATRA) / BMP-2 / p21 / アクチビン / 破骨細胞 / ビタミンD3 / 骨芽細胞 / 骨吸収 / IL-1α / プロスタグランジンE2 / activin / osteoclast / vitamin D3 / チオレドキシン / 造血幹細胞移植 / 遺伝子治療 / 薬剤耐性 / thioredoxin / hematopoietic stem cell transplantation / gene therapy / drug resistance / 急性前骨髄球性白血病 / all-trans retinoic acid(ATRA) / ATRA抵抗性 / acute promyelocytic leukemia / ATRA resistance / 骨髄腫 / アポプトーシス / G1期停止 / アポトーシス / myeloma / apoptosis / G1 arrest / トロンボポエチン / 巨核球 / リン酸化 / 造血 / セリン残基 / レセプター / thrombopoietin / megakaryocyte / Phosphorylation / hematopoiesis / 白血病 / ユビキチン・リガーゼ / 薬学 / 転写因子 / 癌 / シグナル伝達 Less

Fundamental research for developing new therapeutic approach of multiple myeloma targeting its progenitor cells by reactive oxygen species (ROS)Principal Investigator
- Principal Investigator
  
  Kizaki Masahiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saitama Medical University
Development of new therapeutic approach for multiple myeloma targeted against biological properties of bone marrow microenvironmentPrincipal Investigator
- Principal Investigator
  
  KIZAKI Masahiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saitama Medical University
Development of novel molecular-targeting therapy for multiple myeloma against its progenitor cellsPrincipal Investigator
- Principal Investigator
  
  KIZAKI Masahiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saitama Medical University
Regulation of human leukemic stem cell by reactive oxygen species (ROS) and its therapeutic applications in the clinicsPrincipal Investigator
- Principal Investigator
  
  KIZAKI Masahiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saitama Medical University
白血病発症におけるE3ユビキチン・リガーゼの機能解析とその臨床応用
- Principal Investigator
  
  武藤章弘
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hoshi University
Establishment of new molecular-targeted therapy for leukemia mediated through HIF-1 regulation by ROSPrincipal Investigator
- Principal Investigator
  
  KIZAKI Masahiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  KEIO UNIVERSITY
エピジェネティックな転写制御による新たな多発性骨髄腫の治療法の開発Principal Investigator
- Principal Investigator
  
  木崎昌弘
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Keio University
Establishment of novel differentiation-inducing therapy for leukemia with hematopoietic growth factors and arsenic trioxidePrincipal Investigator
- Principal Investigator
  
  KIZAKI Masahiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Keio University
Roles of serine phosphorylation of thrombopoietin receptor
- Principal Investigator
  
  MIYAKAWA Yoshitaka
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Keio University
Anti-myeloma activity of members of the TGF-β family with induction of growth arrest and apoptosis^*
- Principal Investigator
  
  YAMATO Kenji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Tokyo Medical and Dental University
Mechanisms of apoptosis and differentiation induced by arsenic trioxide in leukemic cells and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  KIZAKI Masahiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Keio University
Molecular mechanisms and in vivo models for retinoid resistance in leukemic cells
- Principal Investigator
  
  TAKAYAMA Nobuyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Keio University
The effect of activin A, an antagonist of IL-1 and IL-6, on osteoclast formation.
- Principal Investigator
  
  YAMATO Kenji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Tokyo Medical and Dental University
Establishment of Novel Method for Hematopoietic Stem Cell Transplantation Using Thioredoxin-Gene Transfer Technique
- Principal Investigator
  
  HATTORI Yutaka
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Keio University
脂溶性リガンドによる造血調節:新たな体外増幅を目指してPrincipal Investigator
- Principal Investigator
  
  木崎昌弘
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University
Molecular mechanisms of leukemic cell differentiation and apoptosis by retinoids.Principal Investigator
- Principal Investigator
  
  KIZAKI Masahiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Department of Internal Medicine, Keio University School of Medicine
Role of retinoic acid receptor in normal and leukemic bone marrow stromal cellsPrincipal Investigator
- Principal Investigator
  
  KIZAKI Masahiro
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Keio University

[Book] 多発性骨髄腫治療マニュアル2012
- Author(s)
  木崎昌弘
- Total Pages
  316
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-24591409
[Book] 医薬ジャーナル社2012
- Author(s)
  木崎昌弘
- Total Pages
  251
- Publisher
  造血器腫瘍とエピジェネテイクスー治療への応用と新たな展開ー
- Data Source
  KAKENHI-PROJECT-24591409
[Book] 多発性骨髄腫に対する治療の進め方と治療指針,多発性骨髄腫治療マニュアル2012
- Author(s)
  木崎昌弘
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-21591219
[Book] 多発性骨髄腫。血液疾患最新の治療2011-20132010
- Author(s)
  木崎昌弘
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-21591219
[Book] 多発性骨髄腫。診療ガイドラインUp-To-Date 2010-20112010
- Author(s)
  木崎昌弘, 門脇孝、宮地良樹、小室一成
- Publisher
  メデイカルビュー社
- Data Source
  KAKENHI-PROJECT-21591219
[Book] 急性リンパ性白血病(今日の治療指針 2009 年版)2009
- Author(s)
  木崎昌弘(山口徹、北原光夫、福井次夫(総編集))
- Publisher
  医学書院、東京
- Data Source
  KAKENHI-PROJECT-19591137
[Book] WHO分類第4版による白血病・リンパ系腫瘍の病態学2009
- Author(s)
  木崎昌弘, 他
- Total Pages
  433
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21591219
[Book] 医療スタッフのための白血病ハンドブック2009
- Author(s)
  木崎昌弘(編集)
- Total Pages
  236
- Publisher
  中外医学社、東京
- Data Source
  KAKENHI-PROJECT-19591137
[Book] 今日の治療指針2008
- Author(s)
  木崎昌弘
- Total Pages
  1753
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19591137
[Book] 医療スタッフのための白血病ハンドブック2008
- Author(s)
  木崎昌弘
- Total Pages
  236
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19591137
[Book] 分子標的療法(分子細胞生物学辞典(第2版))2008
- Author(s)
  木崎昌弘(村松正実(編集代表))
- Total Pages
  803
- Publisher
  東京化学同人、東京
- Data Source
  KAKENHI-PROJECT-19591137
[Book] 今日の治療指針2007年版2007
- Author(s)
  木崎昌弘
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19591137
[Book] 造血器腫瘍の分類(カラーテキスト血液学)2007
- Author(s)
  木崎昌弘(押味和夫(編))
- Publisher
  中外医学社、東京
- Data Source
  KAKENHI-PROJECT-19591137
[Book] 急性骨髄性白血病(今日の治療指針 2007 年版)2007
- Author(s)
  木崎昌弘(山口徹、北原光夫、福井次夫(総編集))
- Publisher
  医学書院, 東京
- Data Source
  KAKENHI-PROJECT-19591137
[Book] カラーテキスト血液学2007
- Author(s)
  木崎昌弘
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19591137
[Book] 急性白血病(カラーテキスト血液学)2007
- Author(s)
  木崎昌弘(押味和夫(編))
- Publisher
  中外医学社、東京
- Data Source
  KAKENHI-PROJECT-19591137
[Book] New perspectives in the treatment of hematological malignancies2006
- Author(s)
  Kizaki M, editor
- Total Pages
  393
- Publisher
  Bentham Science Publishers LTD
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591010
[Book] New perspectives in the treatment of hematological malignancies.2006
- Author(s)
  Kizaki M(editor)
- Total Pages
  393
- Publisher
  Bentham Science Publishers Ltd
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591010
[Journal Article] Ribonucleotide Reductase Catalytic Subunit M1 (RRM1) as a Novel Therapeutic Target in Multiple Myeloma.2017
- Author(s)
  Sagawa M, Ohguchi H, Harada T, Samur MK, Tai YT, Munshi NC, Kizaki M, Hideshima T, Anderson KC.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 23 Pages: 5225-5237
- DOI
  10.1158/1078-0432.ccr-17-0263
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09490
[Journal Article] The Role of Intracellular Signaling Pathways in the Pathogenesis of Multiple Myeloma and Novel Therapeutic Approaches2016
- Author(s)
  Kizaki M, Tabayashi T
- Journal Title
  
  J Clin Exp Hematopathol
  
  Volume: 56 Issue: 1 Pages: 20-27
- DOI
  10.3960/jslrt.56.20
- NAID
  130005158798
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09490
[Journal Article] TM-233, a novel analog of 1’-acetoxychavicol acetate (ACA), induces cell death in myeloma cells by inhibiting both JAK/STAT and proteasome activities.2015
- Author(s)
  Sagawa M, Tabayashi T, Kimura Y, Tomikawa T, Nemoto-Anan T, Watanabe R, Tokuhira M, Ri M, Hashimoto Y, Iida S, Kizaki M.
- Journal Title
  
  Cancer Science
  
  Volume: 106 Pages: 438-446
- DOI
  10.1111/cas.12616
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591409, KAKENHI-PROJECT-15K09490
[Journal Article] Structure-activity relationships of benzhydrol derivatives based on 1'-acetoxychavicol acetate (ACA) and their inhibitory activities on multiple myeloma cell growth via inactivation of the NF-κB pathway2015
- Author(s)
  Takashi Misawa, Kosuke Dodo, Minoru Ishikawa, Yuichi Hashimoto, Morihiko Sagawa, Masahiro Kizaki, Hiroshi Aoyama
- Journal Title
  
  Bioorganic Medicinal Chemistry
  
  Volume: 23 Pages: 2241-2246
- DOI
  10.1016/j.bmc.2015.02.039
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670053, KAKENHI-PROJECT-25893038, KAKENHI-PROJECT-15K09490, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-25293027
[Journal Article] Lipopolisaccharide-induced CXCL10 mRNA and six stimulant-mRNA combinations in whole blood: Novel biomarkers for bortezomib responses obtained from a prospective multicenter observation trial for patients with multiple myeloma.2015
- Author(s)
  Watanabe T, Mitsuhashi M, Sagawa M, Ri M, Suzuki K, Abe M, Ohmachi K, Nakagawa Y, Nakamura S, Chosa M, Iida, Kizaki M
- Journal Title
  
  PLoS One
  
  Volume: 10 (6)
- DOI
  10.1371/journal.pone.0128662
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09490
[Journal Article] Shikonin, a naphthoquinone compound, rapidly induces cell death of human myeloma cells via production of reactive oxygen species.2014
- Author(s)
  Kimura T, Nakazato T, Kizaki M.
- Journal Title
  
  Int J Myeloma
  
  Volume: 4 Pages: 13-20
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591409
[Journal Article] A naphthoquinon compound, shikonin, rapidly induces cell death of human multiple myeloma cells via production of reactive oxygen species.2014
- Author(s)
  Kimura T, Nakazato A, Kizaki M
- Journal Title
  
  Int J Myeloma
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591409
[Journal Article] Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway.2014
- Author(s)
  Sadahira K, Sagawa M, Nakazato T, Uchida H, Ikeda Y, Okamoto S, Nakajima H, Kizaki M.
- Journal Title
  
  Int J Oncol.
  
  Volume: 45 Pages: 2278-2286
- DOI
  10.3892/ijo.2014.2652
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591409
[Journal Article] Triptolide induces apoptotic cell death of multiple myeloma cells via transcriptional repression of Mcl-1.2014
- Author(s)
  Nakazato T, Sagawa M, Kizaki M.
- Journal Title
  
  Int J Oncol.
  
  Volume: 44 Pages: 1131-1138
- DOI
  10.3892/ijo.2014.2280
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591409
[Journal Article] Phytohemagglutinin-induced IL-2 mRNA in whole blood can predict bortezomib-induced peripheral neuropathy for multiple myeloma patients.2013
- Author(s)
  Watanabe T, Mitsuhashi M, Sagawa M, Ri M, Suzuki K, Abe M, Ohmachi K, Nakagawa Y, Nakamura S, Chosa M, Iida S, and Kizaki M.
- Journal Title
  
  Blood Cancer J.
  
  Volume: 3
- DOI
  10.1038/bcj.2013.47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591390, KAKENHI-PROJECT-24591409
[Journal Article] In vivo behavior of multiple myeloma cells and their niche in immunodeficiency mice.2012
- Author(s)
  Iriuchishima H, Kizaki M, et al
- Journal Title
  
  PLos ONE
  
  Volume: 7(2)
- DOI
  10.1371/journal.pone.0030557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591219, KAKENHI-PROJECT-21689040, KAKENHI-PROJECT-22591049, KAKENHI-PUBLICLY-23118527, KAKENHI-PROJECT-23249053, KAKENHI-PROJECT-23592231, KAKENHI-PROJECT-23689049, KAKENHI-PROJECT-24591409
[Journal Article] A new disulfide-linked dimmer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells in vitro and in vivo via the HIF-1a pathway : A possible new agent for B-CLL2011
- Author(s)
  Sagawa M, Kizaki M, et al
- Journal Title
  
  Cancer Science
  
  Volume: 102(6) Pages: 1208-1215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591219
[Journal Article] The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-kB activity2011
- Author(s)
  Nakaya A, Kizaki M, et al
- Journal Title
  
  Leukemia Research
  
  Volume: 35(2) Pages: 243-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591219
[Journal Article] Quinone methide tripterine, celastrol, induces apoptosis in human multiple myeloma cells via NF-kB pathway2011
- Author(s)
  Tozawa K, Sagawa M and Kizaki M
- Journal Title
  
  International Journal of Oncology
  
  Volume: 39 Pages: 1117-1122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591219
[Journal Article] Successful treatment of bortezomib with modified schedules up to weekly administration for the patients with refractory/resistance multiple myeloma2011
- Author(s)
  Tokuhira M, Kizaki M, et al
- Journal Title
  
  Leukemia Research
  
  Volume: 35 Pages: 591-597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591219
[Journal Article] メシル酸イマチニブによる慢性骨髄性白血病のマネージメント2010
- Author(s)
  木崎昌弘
- Journal Title
  
  臨床血液
  
  Volume: 51 Pages: 1377-1385
- NAID
  10026727720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591219
[Journal Article] Capsaicin inhibits the mitochondrial function of prohibitin 2 and induces apoptosis2009
- Author(s)
  Kuramori C, Kizaki M, et al
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 379(2) Pages: 519-525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591219
[Journal Article] Cantharidine, a derivative of blister beatles, induces apoptosis in human multiple myeloma cells via inhibition of JAK/STAT pathway.2008
- Author(s)
  Sagawa M, Nakazato T, Uchida H, Ikeda Y, Kizaki M
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 1820-1826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591137
[Journal Article] New tubulin-polymerization inhibitor derived from thalidomide: implications for anti-myeloma effect.2008
- Author(s)
  Kizaki M, Hashimoto Y
- Journal Title
  
  Curr Med Chem. 15
  
  Pages: 754-765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591137
[Journal Article] New tubulin-polymerization inhibitor derived from thalidomide : implications for anti-myeloma effect.2008
- Author(s)
  Kizaki M, et al
- Journal Title
  
  Current Medical Chemistry 15
  
  Pages: 754-765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591137
[Journal Article] New therapeutic approaches to acute myeloid leukemia (AML).2008
- Author(s)
  Uchida H, Inokuchi K, Watanabe R, Tokuhira M, Kizaki M
- Journal Title
  
  Exp Opin Drug Dis. 3
  
  Pages: 689-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591137
[Journal Article] Biological significance of myeloperoxidase (MPO) on green teacomponent, EGCG-induced apoptosis: its therapeutic potential for myeloid leukemia.2008
- Author(s)
  Kizaki M
- Journal Title
  
  Target Oncol. 3
  
  Pages: 45-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591137
[Journal Article] Biological significance of myeloperoxidase (MPO) on green tea component, EGCG-induced apoptosis : its therapeutic potential for myeloid leukemia.2008
- Author(s)
  Kizaki M
- Journal Title
  
  Targeted Oncology 3
  
  Pages: 45-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591137
[Journal Article] Novel tubulin-polymerization inhibitor derived thalidomide directly induces apoptosis of human multiple myeloma cells: possible anti-myeloma mechanism of thalidomide.2008
- Author(s)
  Iguchi T, Noguchi-Yachide T, Hashimoto Y, Nakazato T, Sagawa M, Ikeda Y, Kizaki M
- Journal Title
  
  Int J Mol Med. 21
  
  Pages: 163-168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591137
[Journal Article] A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis in human multiple myeloma cells.2007
- Author(s)
  Sato M, Sagawa M, Nakazato T, Ikeda Y, Kizaki M
- Journal Title
  
  Int J Oncol. 30
  
  Pages: 1453-1459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591137
[Journal Article] Zoledronate induced S phase arrest accompanied by the DNA damage and the activation of ATM/Chk1/cdc25 pathway in human osteosarcoma cells.2007
- Author(s)
  Iguchi T, Miyakawa Y, Saio K, Nakanishi M, Saya H, Ikeda Y, Kizaki M
- Journal Title
  
  Int J Oncol. 31
  
  Pages: 285-291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591137
[Journal Article] Zerumbone, a bioactive sesquterpene, induces G2/M cell cycle arrest and apoptosis of NB4 promyelocytic leukemic cells via a Fas/CD95- and mitochondria-mediated pathway.2007
- Author(s)
  Xian M, Ito K, Nakazato T, Shimizu T, Chen C-K, Yamato K, Murakami A, Ohigashi H, Ikeda Y, Kizaki M
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 118-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591137
[Journal Article] Myeloperoxidase is a key regulator of oxidative stress-mediated apoptosis of myeloid leukemia cells.2007
- Author(s)
  Nakazato T, Sagawa M, Yamato K, Xian M, Yamato T, Suematsu M, Ikeda Y, Kizaki M
- Journal Title
  
  Clin Cancer Res. 13
  
  Pages: 5436-5445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591137
[Journal Article] Induction of apoptosis via the modulation of reactive oxygen species (ROS) production in the treatment of myeloid leukemia.2006
- Author(s)
  Kizaki M
- Journal Title
  
  Curr Pharmaceut Biotechnol 7(5)
  
  Pages: 323-329
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591010
[Journal Article] Induction of apoptosis via modulation of ROS production by natural compounds.2006
- Author(s)
  Kizaki M
- Journal Title
  
  Int J Hematol 83 (4)
  
  Pages: 283-288
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591010
[Journal Article] Induction of apoptosis via the modulation of reactive oxygen species (ROS) production in the treatment of myeloid leukemia.2006
- Author(s)
  Kizaki M, et al.
- Journal Title
  
  Curr Phramaceut Biotechnol 7 (5)
  
  Pages: 323-329
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591010
[Journal Article] Induction of apoptosis via modulation of ROS production by natural compounds2006
- Author(s)
  Kizaki M
- Journal Title
  
  Int.J.Hematol. (In press)
- Data Source
  KAKENHI-PROJECT-17591010
[Journal Article] Induction of apoptosis via modulation of ROS production by natural compounds.2006
- Author(s)
  Kizaki M
- Journal Title
  
  Int J Hematol 83(4)
  
  Pages: 283-288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591010
[Journal Article] A green tea component, catechin, rapidly induces apoptosis of myeloid leukemic cells via modulation of ROS production in vitro and in vivo.2005
- Author(s)
  Nakazato T, Kizaki M, et al.
- Journal Title
  
  Haematologica (印刷中)
- Data Source
  KAKENHI-PROJECT-15659231
[Journal Article] Fucoidan induces apoptosis of human HS-Sultan cells accompanied by the activation of caspase-3 and down-regulation of ERK pathway.2005
- Author(s)
  Aisa Y, Kizaki M et al.
- Journal Title
  
  Am J Hematol 78(1)
  
  Pages: 7-14
- Data Source
  KAKENHI-PROJECT-15659231
[Journal Article] Tubulin-polymerization inhibitors derived from thalidomide.2005
- Author(s)
  Inatsuki S, Kizaki M, et al.
- Journal Title
  
  Bioorg Med chem. Lett 15(2)
  
  Pages: 321-325
- Data Source
  KAKENHI-PROJECT-15659231
[Journal Article] TEL/AML1 overcomes resistance through transcriptional repression of multidrug resistance-1 (MDR-1) gene expression.2004
- Author(s)
  Asakura k, Kizaki M, et al.
- Journal Title
  
  Mol Cancer Res 2(6)
  
  Pages: 339-347
- Data Source
  KAKENHI-PROJECT-15659231
[Journal Article] Induction of apoptosis in human myeloid leukemic cells by ACA through a mitochondrial- and Fas-mediated dual pathway.2004
- Author(s)
  Ito k, Kizaki M, et al.
- Journal Title
  
  Clin Cancer Res 10(6)
  
  Pages: 2120-2130
- Data Source
  KAKENHI-PROJECT-15659231
[Journal Article] A novel mechanism for imatinib mesylate (STI571) resistance in CML cell line KT-1:Role of TC-PTP for modulation signals down stream from the BCR/ABL fusion protein.2004
- Author(s)
  Shimizu T, Kizaki M, et al.
- Journal Title
  
  Exp Hematol 32(11)
  
  Pages: 1057-1063
- Data Source
  KAKENHI-PROJECT-15659231
[Presentation] 多発性骨髄腫におけるRibonucleotide reductase large subunit (RRM1)の新規治療標的としての有用性2017
- Author(s)
  佐川森彦、大口裕人、原田武志、Samur MK、Tai Y-Z、Munshi NC, 木崎昌弘、秀島輝、Anderson KC
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09490
[Presentation] 分子標的療法：ビタミンから創薬へ2017
- Author(s)
  木崎昌弘
- Organizer
  第79回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09490
[Presentation] 細胞周期チェックポイントキナーゼを標的とした多発性骨髄腫に対する新しい治療2017
- Author(s)
  多林孝之、田中佑加、高橋康之、富川武樹、佐川森彦、阿南朋恵、渡部玲子、得平道英、木崎昌弘
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09490
[Presentation] Inhibition of WEE1 induces cell death of both bortezomib- and lenalidomide-resistant multiple myeloma cells: a novel therapeutic approach targeting cell-cycle checkpoint kinase.2016
- Author(s)
  Tabayashi T, Tanaka Y, Takahashi Y, Kimura Y, Tomikawa T, Sagawa M, Anan-Nemoto T, Watanabe R, Tokuhira M, Kizaki M
- Organizer
  58th Annual Meeting of American Society of Hematology
- Place of Presentation
  San Diego（アメリカ合衆国）
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-15K09490
[Presentation] 造血器腫瘍における治療の進歩：ビタミンから分子標的治療薬へ2016
- Author(s)
  木崎昌弘
- Organizer
  第14回日本臨床腫瘍学会
- Place of Presentation
  神戸国際展示場・会議場（神戸）
- Year and Date
  2016-07-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K09490
[Presentation] 分子病態に基づく造血器腫瘍の診断と治療2016
- Author(s)
  木崎昌弘
- Organizer
  第17回日本検査血液学会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2016-08-06
- Invited
- Data Source
  KAKENHI-PROJECT-15K09490
[Presentation] The efficacy and safety of weekly bortezomib containing VMP followed by bortezomib maintenance therapy in unfit or frail multiple myeloma patients.2016
- Author(s)
  Takezako N, Tokuhira M, Sekiguchi N, Kurihara Y, Ito K, Kurimoto M, Suzuki K, Kizaki M
- Organizer
  58th Annual Meeting of American Society of Hematology
- Place of Presentation
  San Diego（アメリカ合衆国）
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-15K09490
[Presentation] Novel therapy for both bortezomib- and lenalidomide-resistant multiple myeloma targeting TOPK.2016
- Author(s)
  高橋康之、多林孝之、田中佑加、木村勇太、富川武樹、佐川森彦、阿南朋恵、渡部玲子、得平道英、木崎昌弘
- Organizer
  第78回日本血液学会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K09490
[Presentation] TM-233, a novel analog of ACA, induces cell death in multiple myeloma cells by targeting JAK/STAT and proteasome dual pathways.2015
- Author(s)
  Kizaki M, Tabayashi T, Sagawa M, Tomikawa T, Tokuhira M, Iida S, Li M, Hashimoto Y
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15K09490
[Presentation] 新規NF-κB阻害剤TM-233による骨髄腫細胞におけるボルテゾミブ耐性の克服2015
- Author(s)
  多林孝之、佐川森彦、富川武樹、高橋康之、木村勇太、阿南朋恵、渡部玲子、得平道英、李政樹、飯田真介、木崎昌弘
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  ホテル金沢（石川県・金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K09490
[Presentation] Novel Therapeutic approach to overcome both bortezomib and lenalidomide resistant multiple myeloma by targeting TOPK/PBK.2015
- Author(s)
  Tabayashi T, Takahashi T, Kimura Y, Tomikawa T, Nemoto Anan T, Watanabe R, Tokuhira M, Mori S, Kizaki M
- Organizer
  57th Annual Meeting of American Society of Hematology
- Place of Presentation
  オーランド（アメリカ合衆国）
- Year and Date
  2015-12-05
- Data Source
  KAKENHI-PROJECT-15K09490
[Presentation] 多発性骨髄腫の治療：現状と展望2014
- Author(s)
  木崎昌弘
- Organizer
  日本内科学会東北地方会第63回生涯教育講演会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2014-06-21
- Invited
- Data Source
  KAKENHI-PROJECT-24591409
[Presentation] TM-233 exerts anti-myeloma activity bortezomib-resistance in human multiple myeloma cells by targeting NF-κB and JAK/STAT dual-signaling pathways.2013
- Author(s)
  Sagawa M, Tomikawa T, Anan T, Tabayashi T, Watanabe R, Tokuhira M, Ri M, Hashimoto Y, Iida S, and Kizaki M
- Organizer
  55th Amecican Society of Hematology Annual Meeting
- Place of Presentation
  New Orleans (Ernest N. Morial Convention Center), LA, USA
- Data Source
  KAKENHI-PROJECT-24591409
[Presentation] Interim analysis of clinical trial of MPB followed by bortezomib maintenance therapy for elderly patients with newly diagnosed multiple myeloma.2013
- Author(s)
  Tokuhira M, Takezako N, Nakazato T, Sasaki M, Handa T, Ikuta K, Ikezoe T, Matsumoto M, Aotsuka N, Taguchi J, Shimomura S, Chin K, Ichikawa K, Usuki K, Ohyashiki K, Nara M, Kishi K, Kuroda Y, Nakamura Y, Kizaki M, et al.
- Organizer
  International Myeloma Workshop
- Place of Presentation
  Kyoto (ICC), Japan
- Data Source
  KAKENHI-PROJECT-24591409
[Presentation] 造血器腫瘍に対する分子標的療法の最前線2012
- Author(s)
  木崎昌弘
- Organizer
  第59回日本臨床検査医学会
- Place of Presentation
  京都国際会館（京都）
- Invited
- Data Source
  KAKENHI-PROJECT-24591409
[Presentation] Quinone methide triptrine, celastrol, induces apoptosis in human myeloma cells via NF-kB pathway2011
- Author(s)
  Sagawa M, Kizaki M, et al
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] 多発性骨髄腫の新たな治療展開2011
- Author(s)
  木崎昌弘
- Organizer
  第33回腎臓病セミナー
- Place of Presentation
  東京(海運クラブ)(招待講演)
- Year and Date
  2011-08-27
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] New therapeutic approach for multiple myeloma : Dvelopment of novel molecular targeting agents2011
- Author(s)
  Kizaki M
- Organizer
  The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
- Place of Presentation
  Tokyo (The University of Tokyo, Hongo Campus)(招待講演)
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] New therapeutic approach for multiple myeloma : Dvelopment of novel molecular targeting agents2011
- Author(s)
  Kizaki M
- Organizer
  The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] シンポジウム:WHO分類第4版の概要と改訂のポイント2010
- Author(s)
  木崎昌弘
- Organizer
  第11回日本検査血液学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-07-24
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] 教育講演:メシル酸イマチニブによる慢性骨髄性白血病のマネージメント2010
- Author(s)
  木崎昌弘
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] 造血器腫瘍治療薬の作用と治療効果:チロシンキナーゼ阻害薬と慢性骨髄性白血病2009
- Author(s)
  木崎昌弘
- Organizer
  第10回検査血液学会
- Place of Presentation
  甲府
- Year and Date
  2009-07-04
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] 形質細胞腫瘍の病態研究と治療開発の最近の進歩2009
- Author(s)
  木崎昌弘
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] 形質細胞腫瘍と類縁疾患の治療:現状と将来展望2009
- Author(s)
  木崎昌弘
- Organizer
  第49回日本リンパ網内系学会
- Place of Presentation
  淡路島
- Year and Date
  2009-07-10
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] Gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-kB activity with clinical potential2009
- Author(s)
  Kizaki M
- Organizer
  12th International Conference on Differentiation Therapy
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] 形質細胞腫瘍の病態研究と治療開発の最近の進歩2009
- Author(s)
  木崎昌弘
- Organizer
  第68回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] Gold compound auranofin(RIDAURA〇! R) induces apoptosis of human myeloma cells by targeting STAT3 and NF-kB pathways, with clinical potential.2009
- Author(s)
  Sagawa M, Kizaki M, et al
- Organizer
  51th Annual Meeting of American Society of Hematology
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] Gold compound auranofin(RIDAURA)induces apoptosis of human multiple myeloma cells by targeting STAT3 and NF-κB pathway, with clinical potential2009
- Author(s)
  Sagawa M, Kizaki M, et al
- Organizer
  51^<th> Annual Meeting of American Society of Hematology
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2009-12-06
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] Gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and NF-κB activity with clinical potential2009
- Author(s)
  木崎昌弘
- Organizer
  12^<th> International Conference on Differentiation Therapy
- Place of Presentation
  Chicago, IL, USA
- Year and Date
  2009-11-25
- Data Source
  KAKENHI-PROJECT-21591219
[Presentation] 多発性骨髄腫に対する新たな分子標的療法の開発。腫瘍別シンポジウム3 造血器腫瘍における分子・細胞療法の開発2008
- Author(s)
  木崎昌弘
- Organizer
  第67 回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19591137
[Presentation] 多発性骨髄腫に対する新たな分子標的療法の開発2008
- Author(s)
  木崎昌弘
- Organizer
  第67回日本癌学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19591137
[Presentation] Gossypol induces apoptosis in myeloma cells by modulating phosphorylation of Bcl-2.2007
- Author(s)
  Sadahira K, Sagawa M, Uchida H, Ikeda Y, and Kizaki M
- Organizer
  第66 回日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591137
[Presentation] Oxidative stress-induced apoptosis in myeloid leukiemia: biological significance of myeloperoxidase (MPO) and its implications for prognosis.2007
- Author(s)
  Kizaki M
- Organizer
  Korean Society of Hematology The Fourth AML/MDS Working Party Symposium.
- Place of Presentation
  Busan, Korea
- Data Source
  KAKENHI-PROJECT-19591137
[Presentation] Oxidative stress-induced apoptosis in myeloid leukiemia:biological significance of myeloneroxidase(MPO)and its implications for prognosis2007
- Author(s)
  Kizaki M
- Organizer
  韓国血液学会日韓ジョイントシンポジウム
- Place of Presentation
  プサン、韓国
- Data Source
  KAKENHI-PROJECT-19591137
[Presentation] A novel putative mechanism of anti-myloma activity targeted against heat shock protein 27 by derivative of artemisinin, artesnate.2007
- Author(s)
  Chizuka A, Uchida H, Xian MJ, Shimizu T, Ikeda Y, Kizaki M
- Organizer
  49th Annual Meeting of American Society of Hematolog.
- Place of Presentation
  米国、Atlanta
- Data Source
  KAKENHI-PROJECT-19591137
[Presentation] IL-6 シグナル伝達経路阻害による金製剤auranofin の多発性骨髄腫に対するアポトーシス誘導2007
- Author(s)
  佐川森彦、中谷綾、仲里朝周、内田秀夫、武藤章弘、池田康夫、木崎昌弘
- Organizer
  第69 回日本血液学会・第49 回日本臨床血液学会合同総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591137
[Presentation] Targeting Wnt/β-catenin signaling pathway in multiple myeloma: A possible new therapeutic approach to overcome bortezomib-resistance
- Author(s)
  Tabayashi T, Takahashi T, Kimura Y, Tomikawa T, Sagawa M, Nemoto T, Watanabe R, Tokuhira M, Mori S, Kizaki M
- Organizer
  56th Annual Meeting of American Society of Hematology
- Place of Presentation
  サンフランシスコ（アメリカ合衆国）
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-24591409
[Presentation] TriptolideによるMcl-1抑制を介した多発性骨髄腫に対する抗腫瘍効果の解析
- Author(s)
  佐川森彦、富川武樹、得平道英、木崎昌弘
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24591409
[Presentation] Triptolide induces apoptotic cell death of myeloma cells via transcriptional repression of Mcl-1
- Author(s)
  佐川森彦、仲里朝周、木村勇太、富川武樹、阿南朋恵、多林孝之、渡部玲子、得平道英、木崎昌弘
- Organizer
  第76回日本血液学会総会
- Place of Presentation
  大阪国際会議場（大阪府・大阪市）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24591409
[Presentation] 多発性骨髄腫の診断•治療の進歩と臨床検査の果たす役割り
- Author(s)
  木崎昌弘
- Organizer
  第61回日本臨床検査医学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2014-11-24 – 2014-11-26
- Invited
- Data Source
  KAKENHI-PROJECT-24591409
[Presentation] Targeting Wnt/β-catenin signaling pathway in multiple myeloma
- Author(s)
  多林孝之、佐川森彦、中林千佳、高橋康之、木村勇太、富川武樹、根本朋恵、渡部玲子、得平道英、森茂久、木崎昌弘
- Organizer
  第76回日本血液学会総会
- Place of Presentation
  大阪国際会議場（大阪府・大阪市）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24591409

1. IKEDA Yasuo (00110883)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. MIYAKAWA Yoshitaka (50250238)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. YAMATO Kenji (50174751)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KAMATA Tamihiro (90265794)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HATTORI Yutaka (20189575)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OKUDA Akihiko (60201993)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. NISHIHARA Tatsuji (80192251)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 武藤章弘 (90239468)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 仲里朝周 (10296569)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. ETO Yuzuru

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. UEYAMA Yoshito (30072408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FUKUCHI Yumi (40250237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKAYAMA Nobuyuki (50206893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KINJO Kentaro (90317115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 吉田正 (00182767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 金田利夫 (70339521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MIYAUCHI Yoshiteru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. ISHIKAWA Minoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. MISAWA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 安部正博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIZAKI Masahiro 木崎 昌弘

木ざき 昌弘 キザキ マサヒロ

Research Projects

Research Products

Co-Researchers

Fundamental research for developing new therapeutic approach of multiple myeloma targeting its progenitor cells by reactive oxygen species (ROS)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new therapeutic approach for multiple myeloma targeted against biological properties of bone marrow microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel molecular-targeting therapy for multiple myeloma against its progenitor cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of human leukemic stem cell by reactive oxygen species (ROS) and its therapeutic applications in the clinicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

白血病発症におけるE3ユビキチン・リガーゼの機能解析とその臨床応用

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of new molecular-targeted therapy for leukemia mediated through HIF-1 regulation by ROSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エピジェネティックな転写制御による新たな多発性骨髄腫の治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of novel differentiation-inducing therapy for leukemia with hematopoietic growth factors and arsenic trioxidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of serine phosphorylation of thrombopoietin receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Anti-myeloma activity of members of the TGF-β family with induction of growth arrest and apoptosis^*

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of apoptosis and differentiation induced by arsenic trioxide in leukemic cells and its clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms and in vivo models for retinoid resistance in leukemic cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of activin A, an antagonist of IL-1 and IL-6, on osteoclast formation.

Principal Investigator

Project Period (FY)

KIZAKI Masahiro 木崎昌弘

木ざき昌弘キザキマサヒロ