Nakashima Akira 中島昭

… Alternative Names

NAKASHIMA Akira 中島昭

中島昭ナカシマアキラ

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Researcher Number	20180276
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 藤田医科大学, 医学部, 教授 2014 – 2015: 藤田保健衛生大学, 医学部, 教授 2010 – 2013: 藤田保健衛生大学, 医学部, 准教授 2007: Fujita Health University, School of Medicine, Associate Professor 2002 – 2006: 藤田保健衛生大学, 医学部, 助教授 1998 – 1999: 藤田保健衛生大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Neurology / Basic Section 52030:Psychiatry-related / Basic Section 59040:Nutrition science and health science-related / Neurochemistry/Neuropharmacology Except Principal Investigator General physiology
Keywords	Principal Investigator チロシン水酸化酵素 / パーキンソン病 / リン酸化 / NT5DC2 / Stability / Tyrosine hydroxylase / PEST motif / 安定性 / Parkinson's disease / tyrosine hydroxylase … More / 14-3-3プロテイン / プロテアソーム分解 / 精神疾患 / カテコールアミン / 神経変性疾患 / 食品成分 / DOPAL / ドーパミン代謝 / キサンチン誘導体 / ドパール（DOPAL） / パーキンソン病、 / α-Synuclein / Phosphorylation / αシヌクレイン / Dopamine / Parkinson disease / dopamine / stability / PESTモチーフ / ドーパミン / feedback inhibition / gene therapy / mutant / フィードバック抑制 / 遺伝子治療 / 変異体 / 細胞内安定性制御機構 / 細胞内安定性 / 神経分子病態学 … More Except Principal Investigator Toll-like receptor / CD18 / CD14 / tumor necrotizing factorα / GTP cyclohydrolase "I" / lipopolysaccharide / 6R-tetrahydrobjopterin / NIE-115 cell line / 一酸化窒素合成酵素 / 一酸化窒素 / IκBキナーゼ / IκB / N1E-115細胞 / リポポリサッカライド受容体 / 腫瘍壊死因子-α / テトラヒドロビオプテリン / GTPシクロヒドロラーゼI / リポポリサッカライド / 神経芽細胞腫 Less

新規蛋白質NT5DC2のカテコールアミン合成における機能の解明：精神疾患との関連Principal Investigator
- Principal Investigator
  
  中島昭
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Fujita Health University
Study of food components to suppress the progress of Parkinson's disease: from the metabolism of dopaminePrincipal Investigator
- Principal Investigator
  
  Nakashima Akira
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Fujita Health University
Intracellular stability of tyrosine hydroxylase regulated by proteasomal degradation of the enzyme and neurodegeneration of dopaminergic cellsPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA AKIRA
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Fujita Health University
Regulating mechanism for intracellular stability of tyrosine hydroxylase and neurodegenerationPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Akira
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Fujita Health University
The relationship between the intracellular stability of tyrosine hydroxylase and the neurodegeneration regulated by α-synucleinPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Akira
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Fujita Health University
The relationship between the intracellular stability of tyrosine hydroxylase and the neurodegeneration on Parkison's diseasePrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Akira
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Fujita Health University
Mutant enzymes of tyrosine hydroxylase for an effective gene therapy of PDPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Akira
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Fujita Health University
Analysis of the Tetrahydrobiopterin Biosynthesizing System in Cultured Neuron-Derived Cells
- Principal Investigator
  
  OTA Akira
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Fujita Health University

All 2024 2023 2020 2019 2016 2015 2014 2013 2012 2011 2008 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] Role of NT5DC2 in tyrosine hydroxylase phosphorylation based on the analysis of NT5DC2-binding proteins2024
- Author(s)
  Yamaguchi Hisateru、Hara Satoshi、Ichinose Hiroshi、Nagasaki Hiroshi、Nakashima Akira
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 703 Pages: 149698-149698
- DOI
  10.1016/j.bbrc.2024.149698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07530
[Journal Article] NT5DC2 affects the phosphorylation of tyrosine hydroxylase regulating its catalytic activity.2020
- Author(s)
  Nakashima A, Yamaguchi H, Kondo M, Furumura T, Kodani Y, Kaneko YS, Kawata M, Nagasaki H, Ngatsu T, Ota A
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 127 Issue: 12 Pages: 1631-1340
- DOI
  10.1007/s00702-020-02236-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11655, KAKENHI-PROJECT-18K11004
[Journal Article] Monoamine Oxidase Inhibitor (MAO-I)-Mediated Neuroprotection for Treating Parkinson’s Disease2020
- Author(s)
  Nagatsu T,Nakashima A
- Journal Title
  
  NeuroPsychopharmacotherapy
  
  Volume: 3 Pages: 1-21
- DOI
  10.1007/978-3-319-56015-1_238-1
- ISBN
  9783319560151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11004
[Journal Article] Human tyrosine hydroxylase in Parkinson's disease and in related disorders.2019
- Author(s)
  Nagatsu T, Nakashima A, Ichinose H, Kobayashi K.
- Journal Title
  
  J Neural Transm (Vienna)
  
  Volume: 126(4) Issue: 4 Pages: 397-409
- DOI
  10.1007/s00702-018-1903-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11004, KAKENHI-PUBLICLY-17H05555, KAKENHI-PROJECT-16H06276
[Journal Article] Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells.2019
- Author(s)
  Nakashima A, Yamaguchi H, Kodani Y, Kaneko YS, Kawata M, Nagasaki H, Nagatsu T, Ota A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 516(4) Issue: 4 Pages: 1060-1065
- DOI
  10.1016/j.bbrc.2019.06.156
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11004, KAKENHI-PROJECT-19K11655
[Journal Article] Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells2016
- Author(s)
  Akira Nakashima, Syuhei Ohnuma, Yu Kodani, Yoko S. Kaneko, Hiroshi Nagasaki, Toshiharu Nagatsu, Akira Ota
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 472 Issue: 4 Pages: 598-602
- DOI
  10.1016/j.bbrc.2016.03.022
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461296
[Journal Article] Degradation rate of tyrosine hydroxylase by ubiquitin-proteasome pathway.2015
- Author(s)
  Syuhei Ohnuma, Yuri Nonaka, Yoko S. Kaneko, Yu Kodani, Hiroshi Nagasaki, Toshiharu Nagatsu, Akira Ota and Akira Nakashima
- Journal Title
  
  J Physiol Sci
  
  Volume: 65
- Data Source
  KAKENHI-PROJECT-25461296
[Journal Article] Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G1 phase and protects them from UV light-induced apoptosis.2014
- Author(s)
  Yoko S Kaneko, Akira Ota, Akira Nakashima, Hiroshi Nagasaki, Yu Kodani, Keiji Mori and Toshiharu Nagatsu.
- Journal Title
  
  J Neural Transm
  
  Volume: 122 Pages: 189-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461296
[Journal Article] Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells.2014
- Author(s)
  Yoko S Kaneko, Takeshi Takayanagi, Hiroshi Nagasaki, Yu Kodani, Akira Nakashima, Keiji Mori, Atsushi Suzuki, Mitsuyasu Itoh, Kazunao Kondo, Toshiharu Nagatsu, Miyuki Ota and Akira Ota.
- Journal Title
  
  J Neural Transm
  
  Volume: Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461296
[Journal Article] Intracellular stability of tyrosine hydroxylase: Phosphorylation and proteasomal digestion of the enzyme.2013
- Author(s)
  Akira Nakashima, Yoko S Kaneko, Yu Kodani, Keiji Mori, Hiroshi Nagasaki, Toshiharu Nagatsu and Akira Ota
- Journal Title
  
  Advances in Pharmacology
  
  Volume: 68 Pages: 3-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461296
[Journal Article] A possible pathophysiological role of tyrosine hydroxylase in Parkinson’s disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer.2013
- Author(s)
  Akira Nakashima, Akira Ota, Yoko S Kaneko, Keiji Mori, Hiroshi Nagasaki and Toshiharu Nagatsu
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 120 Pages: 49-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461296
[Journal Article] A possible pathophysiological role of tyrosine hydroxylase in Parkinson's disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer.2013
- Author(s)
  Akira Nakashima
- Journal Title
  
  J Neural Transm
  
  Volume: 120 Issue: 1 Pages: 49-54
- DOI
  10.1007/s00702-012-0828-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590946
[Journal Article] A possible pathophysiological role of tyrosine hydroxylase in Parkinson's disease suggested by postmortem brainbiochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer.2012
- Author(s)
  Nakashima A, Ota A, Kaneko YS, Mori K, Nagasaki H and Nagatsu T.
- Journal Title
  
  J Neural Transm.
  
  Volume: 120 Pages: 49-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590946
[Journal Article] Proteasomal degradation of tyrosine hydroxylase and neurodegeneration.2012
- Author(s)
  Nakashima A.
- Journal Title
  
  J Neurochem.
  
  Volume: 120 Pages: 199-201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590946
[Journal Article] Proteasomal degradation of tyrosine hydroxylase and neurodegeneration2012
- Author(s)
  Akira Nakashima
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 120 Issue: 2 Pages: 199-201
- DOI
  10.1111/j.1471-4159.2011.07562.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590946
[Journal Article] Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme.2011
- Author(s)
  Nakashima A, Mori K, Kaneko YS, Hayashi N, Nagatsu T and Ota A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 407 Pages: 343-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590946
[Journal Article] Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme2011
- Author(s)
  Akira Nakashima, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 407 Pages: 343-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590946
[Journal Article] RNAi of 14-3-3eta protein increases intracellular stability of tyrosine hydroxylase.2007
- Author(s)
  Nakashima A, et. al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 63
  
  Pages: 817-821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500301
[Journal Article] Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.2007
- Author(s)
  Mazzulli JR, Mishizen AJ, Giasson BI, Lynch DR, Thomas SA, Nakashima A, Nagatsu T, Ota A and Ischiropoulos H.
- Journal Title
  
  J Neurosci. 26(39)
  
  Pages: 10068-10078
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Journal Article] RNAi of 14-3-3eta protein increases intracellular stability of tyrosine hydroxvlase2007
- Author(s)
  Nakashima A., et. al.
- Journal Title
  
  Biochem.Biophys.Res.Common. 63
  
  Pages: 817-821
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500301
[Journal Article] RNAi of 14-3-3eta protein increases intracellular stability of tyrosine hydroxylase.2007
- Author(s)
  Nakashima A, Hayashi N, Kaneko YS, Mori K, Sabban EL, Nagatsu T and Ota A.
- Journal Title
  
  Biochem Biophys Res Commun. 363(3)
  
  Pages: 817-821
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Journal Article] The phosphorylation of Ser^<40> of tyrosine hydroxylase has no effect on the stability of the enzyme in PC12 cells.2005
- Author(s)
  Nakashima A, Kaneko YS, Mori K, Nagatsu T, Ota A
- Journal Title
  
  Biogenic Amines 19(4-5)
  
  Pages: 279-288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Deletion of N-terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT-20 cells.2005
- Author(s)
  Akira Nakashima, et al.
- Journal Title
  
  Journal of Neuroscience Research 81
  
  Pages: 110-120
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] The phosphorylation of Ser40 of tyrosine hydroxylase has no effect on the stability of the enzyme in PC12 cells.2005
- Author(s)
  Akira Nakashima, et al.
- Journal Title
  
  Biogenic Amines 19(4,5)
  
  Pages: 279-288
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Deletion of N-terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT-20 cells.2005
- Author(s)
  Akira Nakashima, et al.
- Journal Title
  
  Journal of Neuroscience Research 81(1)
  
  Pages: 110-120
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Corticotropin-releasing factor receptor antagonist attenuates LPS-induced increase of GTP cyclohydrolase I expression at murine locus coeruleus.2005
- Author(s)
  Kaneko YS, Mori K, Nakashima A, Nagatsu I, Nagatsu T, Ota A
- Journal Title
  
  Biogenic Amines 19(4-5)
  
  Pages: 289-297
- NAID
  130005448571
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Deletion of N-terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT-20 cells.2005
- Author(s)
  Nakashima A, Hayashi N, Kaneko YS, Mori K, Egusa H, Nagatsu T, Ota A.
- Journal Title
  
  J Neurosci Res 81(1)
  
  Pages: 110-120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Peripheral lipopolysaccharide induces apoptosis in the murine olfactory bulb.2005
- Author(s)
  Mori K, Kaneko YS, Nakashima A, Nagatsu I, Takahashi H, Ota A.
- Journal Title
  
  Brain Res 1039(1-2)
  
  Pages: 116-129
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Peripheral injection of lipopolysaccharide enhances expression of inflammatory cytokines in murine locus coeruleus : possible role of increased norepinephrine turnover.2005
- Author(s)
  Kaneko YS, Mori K, Nakashima A, Sawada M., Nagatsu I, Ota A
- Journal Title
  
  J Neurochem 94(2)
  
  Pages: 393-404
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] The phosphorylation of Ser40 of tyrosine hydroxylase has no effect on the stability of the enzyme in PC12 cells.2005
- Author(s)
  Akira Nakashima, et al.
- Journal Title
  
  Biogenic Amines 19
  
  Pages: 279-288
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Deletion of N-terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT-20 cells.
- Author(s)
  Akira Nakashima, et al.
- Journal Title
  
  Journal of Neuroscience Research (in press)
- Data Source
  KAKENHI-PROJECT-16500247
[Journal Article] Intracellular stability of tyrosine hydroxylase: Phosphorylation and proteasomal digestion of the enzyme.
- Author(s)
  Nakashima A, Kaneko YS, Kodani Y, Mori K, Nagasaki H, Nagatsu T and Ota A.
- Journal Title
  
  Adv Pharmacol.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] Nt5dc2 regulates the phosphorylation of tyrosine hydroxylase2023
- Author(s)
  H. YAMAGUCHI, S. HARA, H. ICHINOSE, H. NAGASAKI, A. NAKASHIMA
- Organizer
  Neuroscience 2023 (Society for Neuroscience)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07530
[Presentation] チロシン水酸化酵素のリン酸化とプロテアソーム分解2013
- Author(s)
  中島昭、金子葉子、小谷侑、長崎弘、太田明
- Organizer
  第45回藤田学園医学会　総会
- Place of Presentation
  愛知県豊明市藤田保健衛生大学
- Data Source
  KAKENHI-PROJECT-25461296
[Presentation] Intracellular stability of tyrosine hydroxylase: phosphorylation and proteasomal digestion of the enzyme2012
- Author(s)
  Akira Nakashima
- Organizer
  The Tenth International Catecholamine Symposium
- Place of Presentation
  Pacific Grove, CA, USA
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] Intracellular degradation and localization of tyrosine hydroxylase.2012
- Author(s)
  Nakashima A, Mori K, Kaneko YS, Nagasaki N, Nagatsu T and Ota A.
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本市
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] Intracellular degradation and localization of tyrosine hydroxylase2012
- Author(s)
  Akira Nakashima, et al, 他5名
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  長野県・松本市松本文化会館
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] Phosphorylation and proteasomal digestion of tyrosine hydroxylase.2012
- Author(s)
  Nakashima A, Kaneko YS, Mori K, Nagasaki H, Nagatsu T and Ota A.
- Organizer
  The 11th Biennial Meeting of APSN and 55th Meeting of JSN
- Place of Presentation
  Kobe, Japan
- Year and Date
  2012-10-01
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] Intracellular stability of tyrosine hydroxylase: phosphorylation and proteasomal digestion of the enzyme.2012
- Author(s)
  Nakashima A, Kaneko YS, Mori K, Nagasaki H, Nagatsu T and Ota A.
- Organizer
  The Tenth International Catecholamine Symposium
- Place of Presentation
  Asilomar, CA. USA.
- Year and Date
  2012-09-11
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] Intracellular degradation and localization of tyrosine hydroxylase; phosphorylation and proteasomal digestion of the enzyme.2011
- Author(s)
  Nakashima A, Mori K, Kaneko YS, Nagasaki H, Hayashi H, Nagatsu T and Ota A.
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington D.C., USA
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] Intracellular degradation and localization of tyrosine hydroxylase : phosphorylation and proteasomal digestion of the enzyme2011
- Author(s)
  Akira Nakashima, et al, 他6名
- Organizer
  Neuroscience 2011 (Annual Meeting of Society for Neuroscience)
- Place of Presentation
  Washington DC, USA Convention Centor
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-22590946
[Presentation] Down-regulation of 14-3-34 protein by RNAi increases stability of exogenous tyrosine hydroxylase in PC12D cells2008
- Author(s)
  Akira Nakashima, Nobuhiro Hayashi, Yoko S. Kaneko, Keiji Mori, Esther L. Sabban, Toshiharu Nagatsu, Akira Ota
- Organizer
  The 85th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] Down-regulation of 14-3-3η protein by RNAi increases stability of exogenous tyrosine hydroxylase in PC12D cells2008
- Author(s)
  Nakashima A., et. al.
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京都
- Year and Date
  2008-03-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] N-terminus of tyrosine hydroxylase regulates the intracellular stability of the enzyme2007
- Author(s)
  Nakashima A., et. al.
- Organizer
  第50回日本神経化学会大会
- Place of Presentation
  横浜市
- Year and Date
  2007-09-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] チロシン水酸化酵素のN端は本酵素の細胞内安定性を調節する2007
- Author(s)
  中島昭
- Organizer
  第39回藤田学園医学会総会
- Place of Presentation
  愛知県豊明市
- Year and Date
  2007-10-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] The PEST motif in the N-terminus of tyrosine hydroxylase affects the in tracellular stability of the enzyme2007
- Author(s)
  Nakashima A., et. al.
- Organizer
  第84回日本生理学会大会
- Place of Presentation
  大阪市
- Year and Date
  2007-03-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] Down-regulation of 14-3-3 eta protein by RNAi increases stability of exogenous tyrosine hydroxylase in PC12D cells2007
- Author(s)
  Nakashima A., et. al.
- Organizer
  Society for Neuroscience(SFN)meeting
- Place of Presentation
  San Diego,CA,USA
- Year and Date
  2007-11-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] N-terminus of tyrosine hydroxylase regulates the intracellular stability of the enzyme2007
- Author(s)
  Nakashima Akira, Hayashi Nobuhiro, Kaneko Yoko, Mori Keiji, Nagatsu Toshiharu, Ota Akira
- Organizer
  The 50th Annual Meeting of the Japanese Society for Neurochemistry
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] The PEST motif in the N-terminus of tyrosine hydroxylase affects the intracellular stability of the enzyme2007
- Author(s)
  Nakashima Akira, Kaneko Yoko, Mori Keiji, Nagatsu Toshiharu, Ota Akira
- Organizer
  The 84th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] Down-regulation of 14-3-3 eta protein by RNAi increases stability of exogenous tyrosine hydroxylase in PC12D cells2007
- Author(s)
  Akira Nakashima, Nobuhiro Hayashi, Yoko S. Kaneko, Keiji Mori, Esther L. Sabban, Toshiharu Nagatsu, Akira Ota
- Organizer
  Society for Neuroscience meeting 2007
- Place of Presentation
  San Diego, CA, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] N-terminus of tyrosine hydroxylase regulates the intracellular stability of the enzyme2006
- Author(s)
  Nakashima A., et. al.
- Organizer
  第49回日本神経化学会大会
- Place of Presentation
  名古屋市
- Year and Date
  2006-09-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] The phosphorylation of Ser40 of tyrosine hydroxylase has no effect on the stability of the enzyme.2006
- Author(s)
  Nakashima Akira, Kaneko Yoko, Mori Keiji, Nagatsu Toshiharu, Ota Akira
- Organizer
  The 49th Annual Meeting of the Japanese Society for Neurochemistry
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500301
[Presentation] Degradation rate of tyrosine hydroxylase by ubiquitin-proteasome pathway.
- Author(s)
  Syuhei Ohnuma, Yuri Nonaka, Yoko S. Kaneko, Yu Kodani, Hiroshi Nagasaki, Toshiharu Nagatsu, Akira Ota and Akira Nakashima
- Organizer
  第９２回日本生理学会
- Place of Presentation
  兵庫県神戸市・神戸国際会議場・展示場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25461296

1. OTA Akira (10247637)

# of Collaborated Projects: 6 results

# of Collaborated Products: 27 results
2. HAYASHI Nobuhiro (80267955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. MORI Keiji (40239596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAGATSU Toshiharu (40064802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. 山口央輝 (70319250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. NAGASAKI Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 金子葉子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 小谷侑

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 河田美穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakashima Akira 中島 昭

NAKASHIMA Akira 中島 昭

中島 昭 ナカシマ アキラ

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Co-Researchers

新規蛋白質NT5DC2のカテコールアミン合成における機能の解明：精神疾患との関連Principal Investigator

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Study of food components to suppress the progress of Parkinson's disease: from the metabolism of dopaminePrincipal Investigator

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Intracellular stability of tyrosine hydroxylase regulated by proteasomal degradation of the enzyme and neurodegeneration of dopaminergic cellsPrincipal Investigator

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Regulating mechanism for intracellular stability of tyrosine hydroxylase and neurodegenerationPrincipal Investigator

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The relationship between the intracellular stability of tyrosine hydroxylase and the neurodegeneration regulated by α-synucleinPrincipal Investigator

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The relationship between the intracellular stability of tyrosine hydroxylase and the neurodegeneration on Parkison's diseasePrincipal Investigator

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Mutant enzymes of tyrosine hydroxylase for an effective gene therapy of PDPrincipal Investigator

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Analysis of the Tetrahydrobiopterin Biosynthesizing System in Cultured Neuron-Derived Cells

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[Journal Article] Role of NT5DC2 in tyrosine hydroxylase phosphorylation based on the analysis of NT5DC2-binding proteins2024

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[Journal Article] NT5DC2 affects the phosphorylation of tyrosine hydroxylase regulating its catalytic activity.2020

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[Journal Article] Monoamine Oxidase Inhibitor (MAO-I)-Mediated Neuroprotection for Treating Parkinson’s Disease2020

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[Journal Article] Human tyrosine hydroxylase in Parkinson's disease and in related disorders.2019

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[Journal Article] Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells.2019

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Nakashima Akira 中島昭

NAKASHIMA Akira 中島昭

中島昭ナカシマアキラ