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Hisanaga Shin-ichi  久永 眞市

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… Alternative Names

HISANAGA Shin-ichi  久永 眞市

HISANAGA Shinichi  久永 真一

久永 眞市  ヒサナガ シンイチ

久永 真市  ヒサナカ゛ シンイチ

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Researcher Number 20181092
Other IDs
External Links
Affiliation (Current) 2025: 東京都立大学, 理学研究科, 客員教授
Affiliation (based on the past Project Information) *help 2020 – 2022: 東京都立大学, 理学研究科, 客員教授
2018 – 2019: 首都大学東京, 理学研究科, 客員教授
2018: 首都大学東京, 理学研究科, 教授
2018: 首都大学東京, 理工学研究科, 客員教授
2013 – 2017: 首都大学東京, 理工学研究科, 教授 … More
2011: 首都大学東京, 大学院理工学研究科, 教授
2007 – 2011: Tokyo Metropolitan University, 大学院・理工学研究科, 教授
2006 – 2009: 首都大学東京, 理工学研究科, 教授
2006: 首都大学東京, 大学院理工学研究科, 教授
2005: Tokyo Metropolitan University, Faculty of Urban Liberal Arts, Professor, 都市教養学部, 教授
2002 – 2004: 東京都立大学, 大学院・理学研究科, 教授
1998 – 2004: TOKYO METROPOLITAN UNIVERSITY, 理学研究科, 教授
1997: 東京都立大学, 大学院・理学研究科, 教授
1992 – 1996: 東京工業大学, 生命理工学部, 助教授
1990: Tokyo Institute of Technology Lab. Biodynamics. Ass. Prof., 生命理工学部, 助教授
1989: 東京大学, 医学部, 助手
1988: 東京大学, 医学部解剖学教室, 助手
1987: 東京大学, 医学部, 助手
1986: 東京大学, 医学部・解剖学教室, 助手
1986: 東京大学, 医学部解剖学教室, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Cell biology / Neurochemistry/Neuropharmacology / Functional biochemistry / Basic Section 46030:Function of nervous system-related / Neurochemistry/Neuropharmacology / Functional biochemistry / Neurochemistry/Neuropharmacology / 分子細胞生物学
Except Principal Investigator
分子遺伝学・分子生理学 … More / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / General anatomy (including Histology/Embryology) / Biological Sciences Less
Keywords
Principal Investigator
リン酸化 / Cdk5 / 神経細胞 / カルパイン / プロテアソーム / p35 / サイクリン / cdc2キナーゼ / 酵素 / CDK5 … More / タウ / ニューロフィラメント / アルツハイマー病 / 神経 / 蛋白分解 / 神経科学 / プロテインキナーゼ / シグナル伝達 / 脳 / タンパク質 / 脳・神経 / 細胞骨格 / がん / 細胞分裂 / Neuron / LMTK1 / エンドソーム / 老化 / 神経細胞死 / 記憶 / 長期増強 / カルシウム / 軸索 / cdk5 / 微小管 / 小胞輸送 / スパイン / Proteasome / Alzheimer / Protein kinase / Calpain / phosphorylation / proteasome / Rab / サイクリン依存性キナーゼ / タンパク分解 / 認知症 / 脳神経疾患 / 痴呆 / 蛋白質 / NMDA / シナプス / 細胞死 / 細胞増殖 / ヒ-ラ細胞 / PHF / キナーゼ / LMTK / 神経変性疾患 / 神経回路 / 高次脳機能 / APP / BACE1 / 記憶形成 / 神経突起伸長 / 細胞・組織 / 神経突起 / 発現解析 / 行動解析 / 膜輸送 / ノックアウトマウス / マウス / 自閉症 / Sienal transduction / Calo ain / Phosohorvlation / 細胞膜 / アルツハイマー / 細包膜 / 分解 / Siganal transduction / Phosphorylation / シナプ / グルタミン酸受容体 / Neuronal cell death / calpain / BDNF / neurons / cyclin / cdc2 kinase / 培養細胞 / two-hybridシステム / 神経栄養因子 / チロシンキナーゼ / CDK / 脳由来神経栄養因子 / Grab / GRAB / 発生・分化 / AATYK1 / AAYK1 / リサイクリング / エンドサイトーシス / AATYK / CIN85 / 増殖 / 分化 / 膜結合 / ミリストイル化 / プロテアーゼ / 酸素 / グルタミン酸 / Cdk / FTDP-17 / FTDP17 / p25 / 加齢 / 軸索輸送 / モーター蛋白 / 軸索変性疾患 / reelin / 脳形成 / 軸策再生 / 卵 / 減数分裂 / ヒトデ / cdc2 / ニューロフィメント / 老人性痴呆症 / HeLa細胞 / 中間径線維 / cdcキナーゼ / タウ蛋白 … More
Except Principal Investigator
微小管 / 細胞骨格 / リン酸化 / 分裂装置 / MAP / Alzheimer / Parkinson / NACP / NAC / Kinesin / キネシン / 収縮環 / 急速凍結法 / タウ / 細胞質分裂 / M期 / cdc2キナーゼ / アフリカツメガエル卵無細胞系 / 収縮環形成 / イメージング / リン酸化解析 / Tau / Thr231 / 核局在 / Cdk / タウアイソフォーム / phosphorylation / ピック病 / 皮質基底核変性症 / 嗜銀顆粒性認知症 / Phos-Tag / アルツハイマー病 / タウオパチー / マーモセット / Phos-Tag SDS-PAGE / Synaptic Transmission / Axonal transpsort / Morphogenesis / MAPs / Microtubule / Cytoskeleton / Neuron / ニューロフィラメント / シナプス / ニューロフィラメントアクチン / 分子構築と動態 / 軸索輸送のメカニズム / 蛍光消褪法 / ニューロフィラメントリン酸化 / ニューロフィラメントの重合メカニズム / カルパクチン1 / 伝達物質放出 / 副腎髄質細胞 / 微小管関連蛋白MAP1B / タウ蛋白 / ニュ-ロフィラメント / 軸索輸送 / 形態形成 / 微小管関連蛋白 / 神経細胞 / Gene regulation / Tubulin / Lewy bodies / 細胞毒性 / 神経変性 / Synuclein / tubulin / ロテノン / Lewy小体 / Dynein / Mitotic apparatus / Contractile ring / Intermediate filaments / Microtubules / Action filaments / Cytokinesis / ミオシン / 細胞接着装置 / ダイニン / 中間径繊維 / アクチン繊維 / chromotophore / Heterogeneity / actin-myosin / Phosphorylation / Radixin / neurofilaments / microtubule-dynein / cytoskeleton / 鞭毛外腕欠如株 / adherence junction / ヤリイカの巨大神経 / Map2 / in vitro再構成運動系 / ダイニンーチュ-ブリン / アクチンーミオシン / ニュ-ロフイラメント / 再構成運動系 / 動的不安定性 / ダイニン-チュ-ブリン / アクチン-ミオシン / 微細管関連蛋白(MAP) / クロスブリッジ / 微細管 / 免疫電子顕微鏡法 / 微小管関連蛋白(MAP) / 神経樹状突起 / 樹状突起 / 過活動 / 局在 / 脳神経疾患 / 神経科学 / 神経細胞死 / 凝集 / 脳機能 / 認知症 / 老化 / Aβ / タウタンパク質 / 低分子量G蛋白質 / Rho / 細胞周期 / MAP4 / アクチン・フィラメント Less
  • Research Projects

    (44 results)
  • Research Products

    (231 results)
  • Co-Researchers

    (53 People)
  •  Molecular function and a pathological role of LMTK1, a novel factor regulating spine formationPrincipal Investigator

    • Principal Investigator
      Hisanaga Shin-ichi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 46030:Function of nervous system-related
    • Research Institution
      Tokyo Metropolitan University
  •  Tauopathy Analysis of tau phosphorylation specific to neurodegenerative diseases and elucidation of pathogenic factors

    • Principal Investigator
      KIMURA Taeko
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
      National Institutes for Quantum and Radiological Science and Technology
  •  Studies on physiological function and neuropathology of novel brain protein kinase LMTK1Principal Investigator

    • Principal Investigator
      Hisanaga Shin-ichi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan University
  •  Mechanism of tau protein aging and neurodegeneration

    • Principal Investigator
      Takashima Akihiko
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Gakushuin University
      National Center for Geriatrics and Gerontology
  •  Physiology and pathology of endocytosis and recycling transport in neuronsPrincipal Investigator

    • Principal Investigator
      Hisanaga Shin-ichi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan University
  •  Regulation of endosome formation and recycling by Cdk5/p35 in neuronsPrincipal Investigator

    • Principal Investigator
      HISANAGA Shin-ichi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokyo Metropolitan University
  •  プロテアソームとカルパインのクロストークと神経機能制御に関する研究Principal Investigator

    • Principal Investigator
      久永 眞市
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan University
  •  Utilization of Cdk5/p35 and its role as a negative modulator in signal transduction pathways in neurons.Principal Investigator

    • Principal Investigator
      HISANAGA Shin-ichi
    • Project Period (FY)
      2007 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan University
  •  Cdk5の異常活性化機構の解明と抑制法開発及びアルツハイマー病細胞死への応用Principal Investigator

    • Principal Investigator
      久永 眞市 (久永 真市)
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan University
  •  Cdk5のシナプス可塑性における役割Principal Investigator

    • Principal Investigator
      久永 真市 (久永 眞市)
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan University
  •  Cdk5の異常活性化機構の解明と抑制法開発及びアルツハイマー病細胞死への応用Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan University
  •  Regulation of Cdk5 activity and function in neuronsPrincipal Investigator

    • Principal Investigator
      HISANAGA Shin-ichi
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan University
  •  アルツハイマー病神経細胞死におけるp25/Cdk5の役割Principal Investigator

    • Principal Investigator
      久永 眞市
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan University
  •  アルツハイマー病神経細胞死におけるp25/Cdk5の役割Principal Investigator

    • Principal Investigator
      久永 眞市
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan University
  •  アルツハイマー病における神経細胞死とCDK5活性化サブユニットp35の限定分解Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan University
  •  Cdk5のダウンレギュレーションと長期増強に関する研究Principal Investigator

    • Principal Investigator
      久永 眞市 (久永 真市)
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan University
  •  Molecular pathophysiology of α-Synuclein : Molecular mechanisms of neurodegenerative diseases

    • Principal Investigator
      UEDA Kenji
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  The novel function of cyclin-dependent kinase 5, a role in long term potentiationPrincipal Investigator

    • Principal Investigator
      HISANAGA Shin-ichi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Tokyo Metropolitan University
  •  CDK5活性化サブユニットp35の分解誘導と分解シグナルの解析Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan University
  •  アルツハイマー病における神経細胞死とCDK5活性化サブユニットp35の限定分解Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan University
  •  軸索再生のプライミング:成熟型軸索から再生型軸索への変換機構Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokyo Metropolitan University
  •  CDK5結合性新規細胞質型チロシンキナーゼの脳形成における役割Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan University
  •  老化に伴うニューロフィラメント軸索輸送障害の発生機序の解明と防御法の確立Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan University
  •  The regulation mechanism of degradation of p35 CDK5 activation subunit in neuronsPrincipal Investigator

    • Principal Investigator
      HISANAGA Shin-ichi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Tokyo Metropolitan University
  •  神経細胞におけるCDK5活性化サブユニットp35の選択的分解機構の解析Principal Investigator

    • Principal Investigator
      久永 眞市
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokyo Metropolitan University
  •  軸索再生のプライミング : 成熟型軸索から再生型軸索への変換機構Principal Investigator

    • Principal Investigator
      久永 眞市
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokyo Metropolitan University
  •  Activation or inactivation mechanism of brain cdc2-like kinase, cdk5Principal Investigator

    • Principal Investigator
      HISANAGA Shin-ichi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cell biology
    • Research Institution
      TOKYO METROPOLITAN UNIVERSITY
  •  無細胞系における収縮環の形成とその分子機構の解析

    • Principal Investigator
      岸本 健雄
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  M期サイクリン、サイクリンAとBの細胞分裂進行における機能分担に関する研究Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  無細胞系における収縮環の形勢とその分子機構の解析

    • Principal Investigator
      岸本 健雄
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  M期サイクリン,サイクリンAとBの細胞分裂進行における機能分担に関する研究Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  脳cdc2関連キナーゼ/cdk5の活性阻害因子の同定と精製Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokyo Institute of Technology
  •  PHF形成における脳cdc2様NFHキナーゼ/cdk5の役割Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  HeLa細胞分裂期における微小管再構築のcdc2キナーゼによる制御Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  脳cdc2様ニューロフィラメントキナーゼ/cdk5の活性制御に関する研究Principal Investigator

    • Principal Investigator
      久永 真市
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokyo Institute of Technology
  •  HeLa細胞分裂期における微小管再構築のcdc2キナーゼによる制御Principal Investigator

    • Principal Investigator
      久永 眞市
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokyo Institute of Technology
  •  PHF形成における脳cdc2様キナーゼの役割Principal Investigator

    • Principal Investigator
      久永 眞市
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  PHF形成における脳cdc2様キナーゼの役割Principal Investigator

    • Principal Investigator
      久永 眞市
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  哺乳動物脳のニューロフィラメントキナーゼの精製とその性質Principal Investigator

    • Principal Investigator
      久永 眞市
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      分子細胞生物学
    • Research Institution
      Tokyo Institute of Technology
  •  STUDIES ON DYNAMIC PROPERITIES OF CYTOSKELETAL FILAMENT SYSTEMS

    • Principal Investigator
      MABUCHI Issei
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      分子遺伝学・分子生理学
    • Research Institution
      UNIVERSITY OF TOKYO
  •  Dynamic Features of Cytoskeleton in Cell Motility

    • Principal Investigator
      MIKI-NOUMURA Taiko
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      分子遺伝学・分子生理学
    • Research Institution
      Ochanomizu University
  •  Molecular Architecture and Function of the Cytoskeleton

    • Principal Investigator
      HIROKAWA Nobutaka
    • Project Period (FY)
      1987 – 1991
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Research Institution
      University of Tokyo
  •  小脳プルキニエ細胞樹状突起・棘突起内細胞骨格の生後発達

    • Principal Investigator
      HIROKAWA Nobutaka
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      The University of Tokyo
  •  微細管関連細胞骨格の三次元構造及び関連蛋白の局在と機能

    • Principal Investigator
      広川 信隆
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      The University of Tokyo

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  • [Book] タウオパチー神経変性疾患と脳内炎症2020

    • Author(s)
      木村妙子, 久永眞市, 長谷川成人
    • Total Pages
      5
    • Publisher
      別冊BIO Clinica
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Book] Bio Clinica2020

    • Author(s)
      木村妙子、久永眞市、長谷川成人
    • Total Pages
      5
    • Publisher
      北隆館
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Book] 神経細胞におけるCDK5の機能とその異常活性化による神経変性疾患.2013

    • Author(s)
      斎藤太郎、久永眞市
    • Total Pages
      6
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-25290024
  • [Book] Neurofilaments in aged amimals. Cytoskeleton of the Nervous System. pp325-345. Advances in Neurobiology 3. Eds. By R. Nixon and A Yuan.2011

    • Author(s)
      Hisanaga, S., Sasaki, T., and Uchida, A.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Book] 第3版分子生物学、第12章「細胞機能」2011

    • Author(s)
      久永眞市
    • Total Pages
      14
    • Publisher
      丸善
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Book] 分子生物学(細胞機能)(田沼靖一編)第3版の第12章2011

    • Author(s)
      久永眞市
    • Publisher
      丸善
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Book] 細胞機能.「第3版分子生物学」第12章 田沼靖一編2011

    • Author(s)
      久永真市
    • Publisher
      丸善
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Book] Neurofilaments in aged amimals. Cytoskeleton of the Nervous System.2010

    • Author(s)
      Hisanaga, S., et al.
    • Total Pages
      11
    • Publisher
      Springer
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Book] 細胞周期フロンティア(神経細胞におけるCdk5-p35の活用戦略)(佐方功幸・稲垣昌樹・岸本健雄編集)2010

    • Author(s)
      久永眞市, 遠藤良
    • Publisher
      共立出版
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Book] Neurofilaments in aged amimals.Cytoskeleton of the Nervous System.2010

    • Author(s)
      Hisanaga, S., et al.
    • Total Pages
      11
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Book] 神経細胞におけるCdk5-p35の活用戦略.「細胞周期フロンティア」, 佐方功幸, 稲垣昌樹, 岸本健雄 編集, pp242-2472010

    • Author(s)
      久永眞市, 遠藤良
    • Publisher
      共立出版
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Book] 蛋白質 核酸 酵素(多様な神経機能を制御するキナーゼCdk5, 特集にあたって)2009

    • Author(s)
      久永眞市
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Book] The Kinase Activity of Cdk5 and Its Regulation. In Cdk5 book2008

    • Author(s)
      Hisanaga, S. and Ishiguro, K
    • Total Pages
      13
    • Publisher
      Splinger, NY
    • Data Source
      KAKENHI-PROJECT-19044036
  • [Book] The Kinase Activity of Cdk5 and Its Regulation. In Cdk5 book2008

    • Author(s)
      Hisanaga, S. and Ishiguro, K.
    • Total Pages
      13
    • Publisher
      SDlinger, NY
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Book] Cdk5 book(N. and Tsai, L-H., The Kinase Activity of Cdk5 and Its Regulation.)2008

    • Author(s)
      Hisanaga, S., Ishiguro, K.
    • Publisher
      Splinger
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Book] The Kinase Activity of Cdk5 and Its Regulation. In Cdk5 book(eds. Ip, N. and Tsai, L-H.)2008

    • Author(s)
      Hisanaga S., Ishiguro, K.
    • Publisher
      Splinger, NY
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Book] The Kinase Activity of Cdk5 and Its Regulation. In Cdk5 book2008

    • Author(s)
      Hisanaga, S., Ishiguro, K.
    • Total Pages
      13
    • Publisher
      Splinger, NY
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Book] Neurofilaments in aged amimals. Cytoskeleton of the Nervous System. Advances in Neurobiology 3.(Eds. By R. Nixon and A Yuan)

    • Author(s)
      Hisanaga S., Sasaki, T., Uchida, A.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Book] Cyclin-dependent kinase 5: preparation and measurement of kinase activity. In Protein kinase technologies. Neuromethods (Ed., H. Mukai)

    • Author(s)
      Minegishi, S., Hisanaga, S.
    • Publisher
      Springer(in press)
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] In vivo analysis of the phosphorylation of tau and the tau protein kinases Cdk5-p35 and GSK3beta by using Phos-tag SDS-PAGE.2022

    • Author(s)
      Hisanaga, S., Krishnankutty, A., Kimura, T.
    • Journal Title

      J. Proteomics,

      Volume: 262 Pages: 104591-104591

    • DOI

      10.1016/j.jprot.2022.104591

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Journal Article] Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells2022

    • Author(s)
      Kikuchi K, sakamoto S, Uezu A, Yamamoto H, Ishiguro K, Shimamura K, Saito T, Hisanaga S, Nakanishi H
    • Journal Title

      Life Science Alliance

      Volume: 5(8) Issue: 8 Pages: e202201390-e202201390

    • DOI

      10.26508/lsa.202201390

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06643, KAKENHI-PROJECT-21K06190, KAKENHI-PROJECT-22K06226, KAKENHI-PROJECT-19K06544, KAKENHI-PROJECT-19K06664, KAKENHI-PROJECT-19K06942
  • [Journal Article] Valproic acid-induced anxiety and depression behaviors are ameliorated in p39 Cdk5 activator-deficient mice.2022

    • Author(s)
      Takahashi, M., Takasugi, T., Kawakami, A., Wei, R., Ando, K., Ohshima, T., Hisanaga, S.
    • Journal Title

      Neurochem Res.

      Volume: 47 Issue: 9 Pages: 2773-2779

    • DOI

      10.1007/s11064-022-03642-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Journal Article] Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition.2022

    • Author(s)
      Im, D. S., Joselin, A., Svoboda, D., Takano, T., Rousseaux, M. W. C., Callaghan, S., Slack, R. S., Hisanaga, S., Davis, R. J., Park, D. S., Qu, D.
    • Journal Title

      BMC Biol.

      Volume: 20 Issue: 1 Pages: 115-115

    • DOI

      10.1186/s12915-022-01312-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Journal Article] エンドソーム結合性プロテインキナーゼLMTK1によるRab11活性制御と神経機能.2021

    • Author(s)
      高橋美由紀、友村美根子、久永眞市.
    • Journal Title

      生化学

      Volume: 93 Pages: 765-769

    • NAID

      40022742860

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Journal Article] Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE12021

    • Author(s)
      Komaki Keisuke、Takano Tetsuya、Sato Yutaka、Asada Akiko、Ikeda Shikito、Yamada Kaoru、Wei Ran、Huo Anni、Fukuchi Aoi、Saito Taro、Ando Kanae、Murayama Shigeo、Araki Wataru、Kametani Fuyuki、Hasegawa Masato、Iwatsubo Takeshi、Tomomura Mineko、Fukuda Mitsunori、Hisanaga Shin-ichi
    • Journal Title

      The Journal of Biochemistry

      Volume: 170 Issue: 6 Pages: 729-738

    • DOI

      10.1093/jb/mvab094

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07836, KAKENHI-PROJECT-19K06942, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-22K07550, KAKENHI-PROJECT-22K11708, KAKENHI-PROJECT-19K07988, KAKENHI-PROJECT-22H04923
  • [Journal Article] Distinct phosphorylation profiles of tau in brains of patients with different tauopathies.2021

    • Author(s)
      Samimi, N., Sharma, G., Kimura, T., Matsubara, T., Huo, A., Saito, S., Murayama, M., Akatsu, H., Hashizume, Y., Hasegawa, M., Farjam, M., Shahpasand, K., Ando, K., Hisanaga, S.
    • Journal Title

      Neurobiol. Aging

      Volume: 108 Pages: 72-79

    • DOI

      10.1016/j.neurobiolaging.2021.08.011

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06942, KAKENHI-PROJECT-19K07988, KAKENHI-PROJECT-16H06277
  • [Journal Article] Isoform-dependent subcellular localization of LMTK1A and LMTK1B and their roles in axon outgrowth and spine formation2020

    • Author(s)
      Wei Ran、Sugiyama Arika、Sato Yuta、Nozumi Motohiro、Nishino Hironori、Takahashi Miyuki、Saito Taro、Ando Kanae、Fukuda Mitsunori、Tomomura Mineko、Igarashi Michihiro、Hisanaga Shin-ichi
    • Journal Title

      The Journal of Biochemistry

      Volume: - Issue: 1 Pages: 23-32

    • DOI

      10.1093/jb/mvaa019

    • NAID

      40022279141

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06459, KAKENHI-PROJECT-17KK0144, KAKENHI-PUBLICLY-18H04670, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K06942, KAKENHI-PROJECT-18H04013
  • [Journal Article] α-synuclein strains that cause distinct pathologies differentially inhibit proteasome2020

    • Author(s)
      Suzuki Genjiro、Imura Sei、Hosokawa Masato、Katsumata Ryu、Nonaka Takashi、Hisanaga Shin-Ichi、Saeki Yasushi、Hasegawa Masato
    • Journal Title

      eLife

      Volume: 9

    • DOI

      10.7554/elife.56825

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06942, KAKENHI-PROJECT-18H03993, KAKENHI-PLANNED-18H05498, KAKENHI-ORGANIZER-18H05497
  • [Journal Article] LMTK1, a Novel Modulator of Endosomal Trafficking in Neurons2020

    • Author(s)
      Hisanaga Shin-ichi、Wei Ran、Huo Anni、Tomomura Mineko
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: 13 Pages: 112-112

    • DOI

      10.3389/fnmol.2020.00112

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Journal Article] Hyperactive and impulsive behaviors of LMTK1 knockout mice2020

    • Author(s)
      Takahashi Miyuki、Sugiyama Arika、Wei Ran、Kobayashi Shizuka、Fukuda Kimiko、Nishino Hironori、Takahashi Roka、Tsutsumi Koji、Kita Ichiro、Ando Kanae、Manabe Toshiya、Kamiguchi Hiroyuki、Tomomura Mineko、Hisanaga Shin-ichi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 15461-15461

    • DOI

      10.1038/s41598-020-72304-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06901, KAKENHI-PROJECT-19K06942, KAKENHI-PUBLICLY-19H04876, KAKENHI-PROJECT-19H03321, KAKENHI-PROJECT-18K10852
  • [Journal Article] Tau isoform expression and phosphorylateion in marmotset brains.2019

    • Author(s)
      Sharma G, Huo A, Kimura T, Shiozawa S, Kobayashi R, Sahara N, Ishibashi M, Ishigaki S, Saito T, Ando K, Murayama S, Hasegawa M, Sobue G, Okano H, Hisanaga SI.
    • Journal Title

      J Biol Chem.

      Volume: 26;294(30) Pages: 11433-11444

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Journal Article] Pathological progression induced by the frontotemporal dementia-associated R406W tau mutation in patient-derived iPSCs.2019

    • Author(s)
      Nakamura M, Shiozawa S, Tsuboi D, Amano M, Watanabe H, Maeda S, Kimura T, Yoshimatsu S, Kisa F, Karch CM, Miyasaka T, Takashima A, Sahara N, Hisanaga S, Ikeuchi T, Kaibuchi K, Okano H
    • Journal Title

      Stem Cell Reports.

      Volume: 8;13(4) Pages: 684-699

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Journal Article] Cytoplasmic control of Rab family small GTPases through BAG62019

    • Author(s)
      Takahashi Toshiki、Minami Setsuya、Tsuchiya Yugo、Tajima Kazu、Sakai Natsumi、Suga Kei、Hisanaga Shin‐ichi、Ohbayashi Norihiko、Fukuda Mitsunori、Kawahara Hiroyuki
    • Journal Title

      EMBO reports

      Volume: 20 Issue: 4

    • DOI

      10.15252/embr.201846794

    • NAID

      120007127921

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06468, KAKENHI-PUBLICLY-17H05682, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-19K06653, KAKENHI-PUBLICLY-19H05293, KAKENHI-PROJECT-17H03657
  • [Journal Article] CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway2019

    • Author(s)
      Furusawa K, Takasugi T, Chiu YW, Hori Y, Tomita T, Fukuda M, Hisanaga SI
    • Journal Title

      J. Biol. Chem.

      Volume: 294(28) Issue: 28 Pages: 10886-10899

    • DOI

      10.1074/jbc.ra118.005385

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06653, KAKENHI-PROJECT-19K06942, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-18J01378
  • [Journal Article] Tau isoform expression and phosphorylation in marmoset brains2019

    • Author(s)
      Sharma Govinda、Huo Anni、Kimura Taeko、Shiozawa Seiji、Kobayashi Reona、Sahara Naruhiko、Ishibashi Minaka、Ishigaki Shinsuke、Saito Taro、Ando Kanae、Murayama Shigeo、Hasegawa Masato、Sobue Gen、Okano Hideyuki、Hisanaga Shin-ichi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 30 Pages: 11433-11444

    • DOI

      10.1074/jbc.ra119.008415

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07367, KAKENHI-PROJECT-19K06472, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K06942, KAKENHI-PUBLICLY-19H05437, KAKENHI-WRAPUP-19H05447, KAKENHI-PROJECT-16H06277
  • [Journal Article] Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT1A receptor via phosphorylation2019

    • Author(s)
      Takahashi Miyuki、Kobayashi Yuki、Ando Kanae、Saito Yumiko、Hisanaga Shin-ichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 510 Issue: 3 Pages: 370-375

    • DOI

      10.1016/j.bbrc.2019.01.093

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05703, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-19K06739, KAKENHI-PROJECT-19K06942, KAKENHI-PROJECT-18K14742
  • [Journal Article] The LMTK1-TBC1D9B-Rab11A cascade regulates dendritic spine formation via endosome trafficking.2019

    • Author(s)
      Nishino, H., Saito. T., Wei, R., Takano, T., Tsutsumi, T., Taniguchi, M., Ando, K., Tomomura, M., Fukuda, M., Hisanaga, S.
    • Journal Title

      J. Neurosci.

      Volume: 39 Pages: 9491-9502

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Journal Article] S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy2018

    • Author(s)
      Chiku Tomoki、Hayashishita Motoki、Saito Taro、Oka Mikiko、Shinno Kanako、Ohtake Yosuke、Shimizu Sawako、Asada Akiko、Hisanaga Shin-ichi、Iijima Koichi M.、Ando Kanae
    • Journal Title

      Neurobiology of Aging

      Volume: 71 Pages: 255-264

    • DOI

      10.1016/j.neurobiolaging.2018.07.021

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05703, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K08637
  • [Journal Article] otent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.2018

    • Author(s)
      Tarutani A, Arai T, Murayama S, Hisanaga SI, Hasegawa M
    • Journal Title

      Acta Neuropathol Commun

      Volume: 6 Issue: 1 Pages: 29-29

    • DOI

      10.1186/s40478-018-0532-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-18K18443, KAKENHI-PROJECT-18K15359, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K07060
  • [Journal Article] Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy.2018

    • Author(s)
      Kimura T, Sharma G, Ishiguro K, Hisanaga SI.
    • Journal Title

      Front Neurosci.

      Volume: 12 Pages: 44-44

    • DOI

      10.3389/fnins.2018.00044

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K07060
  • [Journal Article] Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy2018

    • Author(s)
      Kimura T, Sharma G, Ishiguro K, Hisanaga SI
    • Journal Title

      Front Neurosci

      Volume: 12 Pages: 44-44

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Journal Article] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.2018

    • Author(s)
      Tuerde, D., Kimura, T., Miyasaka, T., Furusawa, K., Shimozawa, A., Hasegawa, M., Ando, A., Hisanaga, S.
    • Journal Title

      J. Biol, Chem.

      Volume: 293 Issue: 5 Pages: 1781-1793

    • DOI

      10.1074/jbc.m117.798918

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-17K07113, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-17J06398
  • [Journal Article] In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains.2017

    • Author(s)
      Krishnankutty, A., Kimura, T., Saito, T., Aoyagi, K., Asada, A., Takahashi, S., Ando, K., Ohara-Imaizumi, M., Ishiguro, K., Hisanaga, S.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 8602-8602

    • DOI

      10.1038/s41598-017-09239-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-17K07113, KAKENHI-PROJECT-17K08547, KAKENHI-PROJECT-17K09845, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-17J06398, KAKENHI-PROJECT-26460396
  • [Journal Article] Cdk5の多彩な機能-神経細胞から非神経系2017

    • Author(s)
      斎藤太郎、久永眞市
    • Journal Title

      生化学

      Volume: 89 Pages: 710-718

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Journal Article] Cdk5 regulation of the GRAB-mediated Rab8-Rab11 cascade in axon outgrowth.2017

    • Author(s)
      Furusawa, K., Asada, A., Urrutia, P., Gonzalez-Billault, C., Fukuda, M. and Hisanaga, S. I.
    • Journal Title

      J. Neurosci.

      Volume: 37 Issue: 4 Pages: 790-806

    • DOI

      10.1523/jneurosci.2197-16.2017

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01198, KAKENHI-PROJECT-15H04367, KAKENHI-PROJECT-16J06215, KAKENHI-PROJECT-16K07060
  • [Journal Article] 複雑怪奇なリン酸化タンパク質タウのPhos-tag解析2017

    • Author(s)
      木村妙子、久永眞市
    • Journal Title

      電気泳動

      Volume: 61 Pages: 49-52

    • NAID

      130006207357

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Journal Article] Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy2017

    • Author(s)
      Oka Mikiko、Fujisaki Naoki、Maruko-Otake Akiko、Ohtake Yosuke、Shimizu Sawako、Saito Taro、Hisanaga Shin-Ichi、Iijima Koichi M、Ando Kanae
    • Journal Title

      The Journal of Biochemistry

      Volume: 162 Issue: 5 Pages: 335-342

    • DOI

      10.1093/jb/mvx038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08637, KAKENHI-PUBLICLY-17H05703, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15K06712
  • [Journal Article] Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production.2017

    • Author(s)
      Keiko Akasaka-Manya, Masaki Kawamura, Hiroki Tsumoto, Yuko Saitoh, Yuriko Tachida, Shinobu Kitazume, Hiroyuki Hatsuta, Yuri Miura, Shin-ichi Hisanaga, Shigeo Murayama, Yasuhiro Hashimoto, Hiroshi Manya, Tamao Endo
    • Journal Title

      J. Biochem.

      Volume: 161 Issue: 1 Pages: 99-111

    • DOI

      10.1093/jb/mvw056

    • NAID

      40021091544

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460090, KAKENHI-PROJECT-26460394, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16H06277
  • [Journal Article] Phos-tag SDS-PAGE analysis of complicated phosphorylation of a neurodegenerative disease protein tau2017

    • Author(s)
      木村 妙子、久永 眞市
    • Journal Title

      Electrophoresis Letters

      Volume: 61 Issue: 2 Pages: 49-52

    • DOI

      10.2198/electroph.61.49

    • NAID

      130006207357

    • ISSN
      2189-2628, 2189-2636
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07113, KAKENHI-PROJECT-17J06398
  • [Journal Article] Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth.2017

    • Author(s)
      Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga SI.
    • Journal Title

      J Neurosci.

      Volume: 37 Issue: 4 Pages: 790-806

    • DOI

      10.1523/jneurosci.2197-16.2016

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Journal Article] Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.2016

    • Author(s)
      Tarutani A, Suzuki G, Shimozawa A, Nonaka T, Akiyama H, Hisanaga S, and Hasegawa M.
    • Journal Title

      J. Biol. Chem., J. Biol. Chem.

      Volume: 291 Issue: 36 Pages: 18675-18688

    • DOI

      10.1074/jbc.m116.734707

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K21650, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
  • [Journal Article] The kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons.2016

    • Author(s)
      Sharma S, Tsutsumi K, Saito T, Asada A, Ando K, Tomomura T, Hisanaga S.
    • Journal Title

      Genes Cells.

      Volume: 21 Issue: 10 Pages: 1080-1094

    • DOI

      10.1111/gtc.12404

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-16K11487
  • [Journal Article] Two degradation pathways of the p35 Cdk5 activation subunit, dependent and independent of ubiquitination.2016

    • Author(s)
      Takasugi et al.,
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Issue: 9 Pages: 4649-4657

    • DOI

      10.1074/jbc.m115.692871

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25290024, KAKENHI-PLANNED-24112007, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K07060
  • [Journal Article] α-Synuclein fibrils exhibit gain-of-toxic-function, promoting tau aggregation and inhibiting microtubule assembly.2016

    • Author(s)
      Oikawa T, Nonaka T, Hisanaga S, Hasegawa M.
    • Journal Title

      J Biol Chem.

      Volume: 291 Issue: 29 Pages: 15046-15056

    • DOI

      10.1074/jbc.m116.736355

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
  • [Journal Article] Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants.2016

    • Author(s)
      Kimura T, Hosokawa T, Taoka M, Tsutsumi K, Ando K, Ishiguro K, Hosokawa M, Hasegawa M, Hisanaga S.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 33479-33479

    • DOI

      10.1038/srep33479

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15K18366, KAKENHI-PROJECT-16K07060
  • [Journal Article] Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.2016

    • Author(s)
      Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
    • Journal Title

      J Biol Chem

      Volume: 291 Issue: 17 Pages: 8896-907

    • DOI

      10.1074/jbc.m115.713552

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02356, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K21650
  • [Journal Article] Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated.2016

    • Author(s)
      Ando K, Oka M, Ohtake M, Hayashishita M, Shimizu S, Hisanaga S, Iijima KM
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 478 (2) Issue: 2 Pages: 929-934

    • DOI

      10.1016/j.bbrc.2016.08.053

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01564, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15K06712, KAKENHI-PROJECT-16K08637
  • [Journal Article] The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method2016

    • Author(s)
      Kimura T, Hatsuta H, Masuda-Suzukake M, Hosokawa M, Ishiguro K, Akiyama H, Murayama S, Hasegawa M, Hisanaga S
    • Journal Title

      American Journal of Pathology

      Volume: 186 Issue: 2 Pages: 398-409

    • DOI

      10.1016/j.ajpath.2015.10.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09850, KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-25290024, KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-16H06277
  • [Journal Article] Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau.2015

    • Author(s)
      Takahashi M, Miyata H, Kametani F, Nonaka T, Akiyama H, Hisanaga SI, Hasegawa M.
    • Journal Title

      Acta Neuropathol.

      Volume: 129 Issue: 6 Pages: 895-907

    • DOI

      10.1007/s00401-015-1415-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-25290024
  • [Journal Article] Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau.2015

    • Author(s)
      Takahashi, M., Miyata, H., Kametani, F., Nonaka, T., Akiyama, H., Hisanaga, S., Hasegawa, M.
    • Journal Title

      Acta Neuropathol.

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Journal Article] Effects of p35 mutations associated with mental retardation on the cellular function of p35-CDK52015

    • Author(s)
      Takada S, Mizuno K, Saito T, Asada A, Giese KP, Hisanaga S.
    • Journal Title

      PLOSONE

      Volume: 10

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Journal Article] Valproic acid downregulates Cdk5 activity via transcription of p35 mRNA2014

    • Author(s)
      Takahashi, et al.
    • Journal Title

      Biochem. Biophysic Res Commun.

      Volume: 447 Issue: 4 Pages: 678-682

    • DOI

      10.1016/j.bbrc.2014.04.072

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25290024, KAKENHI-PLANNED-26117004
  • [Journal Article] The effect of Cyclin-dependent kinase 5 on voltage-dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state2014

    • Author(s)
      Furusawa et al.,
    • Journal Title

      J. Neurochem

      Volume: 130 Issue: 4 Pages: 498-506

    • DOI

      10.1111/jnc.12746

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25290024, KAKENHI-PLANNED-26117004
  • [Journal Article] LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes2014

    • Author(s)
      Takano et al
    • Journal Title

      Mol Biol. Cell

      Volume: 25 Issue: 11 Pages: 1755-1768

    • DOI

      10.1091/mbc.e14-01-0675

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25290024, KAKENHI-PLANNED-26117004
  • [Journal Article] Physiological and pathological phosphorylation of tau by Cdk52014

    • Author(s)
      Kimura, T., Ishiguro, K., Hisanaga, S.
    • Journal Title

      Frontiers Mol. Neurosci

      Volume: 7 Pages: 65-65

    • DOI

      10.3389/fnmol.2014.00065

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25290024, KAKENHI-PLANNED-26117004
  • [Journal Article] サイクリン依存性キナーゼ5の活性制御機構と神経細胞死における役割2014

    • Author(s)
      斎藤太郎、久永眞市
    • Journal Title

      生体の科学

      Volume: 65 Pages: 266-270

    • Data Source
      KAKENHI-PLANNED-26117004
  • [Journal Article] Phosphorylation of Cdk5 at Tyr15 is not an activation mechanism of Cdk5 downstream of tyrosine kinase activation.2014

    • Author(s)
      Kobayashi, H., Saito, T., Sato, K., Furusawa, K., Hosokawa, T., Tsutsumi, K., Asada, A., Kamada, S., Ohshima, T., and Hisanaga, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Issue: 28 Pages: 19627-19636

    • DOI

      10.1074/jbc.m113.501148

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25640063, KAKENHI-PLANNED-26117004
  • [Journal Article] Preferential targeting of p39-activated Cdk5 to Rac1-induced lamellipodia.2014

    • Author(s)
      Ito, Y., Asada, A., Kobayashi, H., Takano, T., Sharma, G., Saito, T., Ohta, Y., Amano, M., Kaibuchi, K., and Hisanaga, S.
    • Journal Title

      Molecular and Cellular Neurosciences

      Volume: 61 Pages: 34-45

    • DOI

      10.1016/j.mcn.2014.05.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590357, KAKENHI-PROJECT-25290024, KAKENHI-PLANNED-26117004
  • [Journal Article] Phos-tag を用いたCdk5制御サブユニットp35のin vivo リン酸化の定量的解析2012

    • Author(s)
      久永眞市
    • Journal Title

      生物物理化学

      Volume: 56

    • NAID

      130004809458

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Regulation of mitochondrial transport and inter-microtubule spacing by Tau phosphorylation at the sites hyperphosphorylated in Alzheimer’s disease.2012

    • Author(s)
      Shahpasand, S., Uemura, I., Saito, T., Asano, T., Hata, K., Shibata, K., Toyoshima, Y., Hasegawa, M., and Hisanaga, S.
    • Journal Title

      J. Neurosci.

      Volume: 32 Pages: 2430-2441

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.2011

    • Author(s)
      Sato, K., Minegishi, S., Takano, J., Plattner, F., Saito, T., Asada, A., Kawahara, H., Iwata, N., Saido, T. C., Hisanaga, S.
    • Journal Title

      J. Neurochem.

      Volume: 117 Pages: 504-515

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.2010

    • Author(s)
      Minegishi, S., Asada, A., Miyauchi, S., Fuchigami, T., Saito, T., Hisanaga, S.
    • Journal Title

      Biochemistry 49

      Pages: 5482-5493

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] AATYK1A phosphorylation by Cdk5 regulates the recycling endosome pathway.2010

    • Author(s)
      Takano, T., Tsutsumi, K., Saito, T., Asada, A., Tomomura, M., Fukuda, M., Hisanaga, S.
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 783-797

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Cdk5-シナプスにおけるネガティブレギュレーター2010

    • Author(s)
      細川智永、久永真市
    • Journal Title

      生体の科学特集号「シナプスをめぐるシグナリング」 61

      Pages: 470-471

    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] AATYK1A phosphorylation by Cdk5 regulates the recycling endosome pathway.2010

    • Author(s)
      Takano, T., Tsutsumi, K., Saito, T., Asada, A., Tomomura, M., Fukuda, M., Hisanaga S.
    • Journal Title

      Genes Cells 15

      Pages: 783-797

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation.2010

    • Author(s)
      Tsutsumi, K., Takano, T., Endo, R., Fukuda, M., Ohshima, T., Tomomura, M., and Hisanaga, S.
    • Journal Title

      PLoS ONE

      Volume: 5

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.2010

    • Author(s)
      Minegishi, S., Asada, A., Miyauchi, S., Fuchigami, T., Saito, T., and Hisanaga, S.
    • Journal Title

      Biochemistry

      Volume: 49 Pages: 5482-5493

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Regulation and role of Cdk5 kinase activity in neuronal survival and death.2010

    • Author(s)
      Hisanaga, S., and Endo, E.
    • Journal Title

      J. Neurochem.

      Volume: 115 Pages: 1309-1321

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Neuronal expression of two isoforms of mouse Septin 5.2010

    • Author(s)
      Asada, A., Takahashi, J., Taniguchi, M., Yamamoto, H., Kimura, T., Saito, T., Hisanaga S.
    • Journal Title

      J.Neurosci.Res. 88

      Pages: 1309-1316

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] Quantitative Measurement of In Vivo Phosphorylation States of Cdk5 Activator p35 by Phos-tag SDS-PAGE.2010

    • Author(s)
      Hosokawa T., Saito, T., Asada, A., Fukunaga, K., Hisanaga S.
    • Journal Title

      Mol.Cell.Proteomics. 9

      Pages: 1133-1143

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] Regulation and role of Cdk5 kinase activity in neuronal survival and death.2010

    • Author(s)
      Hisanaga, S., Endo, E.
    • Journal Title

      J. Neurochem. 115

      Pages: 1309-1321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] Quantitative Measurement of In Vivo Phosphorylation States of Cdk5 Activator p35 by Phos-tag SDS-PAGE.2010

    • Author(s)
      Hosokawa, T., Saito, T., Asada, A., Fukunaga, K., and Hisanaga, S.
    • Journal Title

      Mol. Cell. Proteomics.

      Volume: 9 Pages: 1133-1143

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation.2010

    • Author(s)
      Tsutsumi, K., Takano, T., Endo, R., Fukuda, M., Ohshima, T., Tomomura, M., Hisanaga S.
    • Journal Title

      PLoS ONE 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] Effect of pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant tau.2009

    • Author(s)
      Yotsumoto, K., Saito, T., Asada, A., Oikawa, T., Kimura, T., Uchida, C., Ishiguro, K., Uchida, T., Hasegawa, M., Hisanaga S.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 16840-16847

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] Commitment of MPP+-induced neuronal cell death by proteasome-mediated degradation of p35 Cdk5 activator.2009

    • Author(s)
      Endo, R., Saito, T.,Asada, A., Kawahara, H., Ohshima, T., Hisanaga S.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 26029-26039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] 多様な神経機能を制御するキナーゼCdk52009

    • Author(s)
      久永真市
    • Journal Title

      蛋白質核酸酵素 54

    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] Novel axonal distribution of neurofilament-H phosphorylated at the GSK3β-phosphorylation site in its E-segment.2009

    • Author(s)
      Sasaki, T., Ishiguro, K., and Hisanaga, S.
    • Journal Title

      J. Neurosci. Res.

      Volume: 87 Pages: 3088-3097

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Novel axonal distribution of neurofilament-H phosphorylated at the GSK3β-phosphorylation site in its E-segment.2009

    • Author(s)
      Sasaki, T., Ishiguro, K., Hisanaga S.
    • Journal Title

      J.Neurosci.Res. 87

      Pages: 3088-3097

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] Effect of pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant tau.2009

    • Author(s)
      Yotsumoto, K., Saito, T., Asada, A., Oikawa, T., Kimura, T., Uchida, C., Ishiguro, K., Uchida, T., Hasegawa, M., Hisanaga, S.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 16840-16847

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Commitment of MPP+-induced neuronal cell death by proteasome-mediated degradation of p35 Cdk5 activator.2009

    • Author(s)
      Endo, R., Saito, T., Asada, A., Kawahara, H., Ohshima, T., and Hisanaga, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 284 Pages: 26029-26039

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Effect of pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant tau.2009

    • Author(s)
      Yotsumoto, K., Saito, T., Asada, A., Oikawa, T., Kimura, T., Uchida, C., Ishiguro, K., Uchida, T., Hasegawa, M., and Hisanaga, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 284 Pages: 16840-16847

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Commitment of MPP+-induced neuronal cell death by proteasome-mediated degradation of p35 Cdk5 activator.2009

    • Author(s)
      Endo, R., Saito, T., Asada, A., Kawahara, H., Ohshima, T., Hisanaga, S.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 26029-26039

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 (Cdk5) complexes.2008

    • Author(s)
      Asada, A., Yamamoto, N., Gohda, M., Saito, T., Hayashi, N., and Hisanaga, S.
    • Journal Title

      J. Neurochem.

      Volume: 106 Pages: 1325-1336

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src.2008

    • Author(s)
      Tsutsumi, K., Tomomura, M., Furuichi, T., Hisanaga S.
    • Journal Title

      Genes to Cells 13

      Pages: 949-964

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 (Cdk5) complexes.2008

    • Author(s)
      Asada, A., Yamamoto, N., Gohda, M., Saito, T., Hayashi, N., Hisanaga S.
    • Journal Title

      J.Neurochem. 106

      Pages: 1325-1336

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.2008

    • Author(s)
      Kaminosono, S., Saito, T., Oyama, F., Ohshima, T., Asada, A., Nagai, Y., Nukina, N., Hisanaga, S.
    • Journal Title

      J. Neurosci 28

      Pages: 8747-8755

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 (Cdk5) complexes.2008

    • Author(s)
      Asada, A., Yamamoto, N., Gohda, M., Saito, T., Hayashi, N., Hisanaga, S.
    • Journal Title

      J. Neuroche 106

      Pages: 1325-1336

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src.2008

    • Author(s)
      Tsutsumi, K., Tomomura, M., Furuichi, T., and Hisanaga, S.
    • Journal Title

      Genes to Cells

      Volume: 13 Pages: 949-964

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.2008

    • Author(s)
      Kaminosono, S., Saito, T., Oyama, F., Ohshima, T., Asada, A., Nagai, Y., Nukina, N., Hisanaga S.
    • Journal Title

      J.Neurosci. 28

      Pages: 8747-8755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.2008

    • Author(s)
      Kaminosono, S., Saito, T., Oyama, F., Ohshima, T., Asada, A., Nagai, Y., Nukina, N., and Hisanaga, S.
    • Journal Title

      J. Neurosci.

      Volume: 28 Pages: 8747-8755

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] p25/Cdk5 promotes the progression of cell death in nucleus of ER-stressed neurons.2007

    • Author(s)
      Saito, T., Konno, T., Asada, A. and Hisanaga, S.
    • Journal Title

      J. Neurochem.

      Volume: 102 Pages: 133-140

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Regulation of the interaction of Disabled-1 with CIN85 by phosphorylation with Cyclin-dependent kinase 5.2007

    • Author(s)
      Sato, Y., Taoka, M., Sugiyama, N., Kubo, K., Fuchigami, T., Asada, A., Saito, T., Nakajima, K., Isobe, T. and Hisanaga, S.
    • Journal Title

      Genes Cells

      Volume: 12 Pages: 1315-1327

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Phosphorylation of adult type sept5 (cdcrel-1) by cyclin-dependent kinase 5 inhibits interaction with syntaxin-1.2007

    • Author(s)
      Taniguchi, T., Taoka, M., Itakura, M., Asada, A., Saito, T., Kinoshita, M., Takahashi, M., Isobe, T., and Hisanaga, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 282 Pages: 7869-7876

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] p25/Cdk5 promotes the progression of cell death in nucleus of ER-stressed neurons.2007

    • Author(s)
      Saito, T., Konno, T., Asada, A., Hisanaga, S.
    • Journal Title

      J. Neurochem 102

      Pages: 133-140

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Supression of calpain-dependent cleavage of the cdk5 activator p35 to p25 by site-specific phosphorylation.2007

    • Author(s)
      Kamei, H., Saito, T, Ozawa, O., Fujita, Y., Asada, A., Bibb, J. A., Saido, T. C., Sorimachi, S., and Hisanaga, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 282 Pages: 1687-1694

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Regulation of the membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.2007

    • Author(s)
      Sato, K., Zhu, Y-S., Saito, T., Yotsumoto, K., Asada, A., Hasegawa, M. and Hisanaga, S.
    • Journal Title

      J. Neurosci. Res.

      Volume: 85 Pages: 3071-3078

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] 神経細胞におけるCdk5活性化サブユニットp35の選択的分解機構。2004

    • Author(s)
      久永眞市
    • Journal Title

      現代医療

    • Data Source
      KAKENHI-PROJECT-16026237
  • [Journal Article] 神経細胞におけるCdk5活性化サブユニットp35の選択的分解機構。2004

    • Author(s)
      久永眞市
    • Journal Title

      現代医療

    • Data Source
      KAKENHI-PROJECT-16015293
  • [Journal Article] Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.

    • Author(s)
      Sato, K., Minegishi, S., Takano, J., Plattner, F., Saito, T., Asada, A., Kawahara, H., Iwata, N., Saido, T.C., Hisanaga S.
    • Journal Title

      J. Neurochem. In press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Journal Article] LMTK1/AATYK1 Is a Novel Regulator of Axonal Outgrowth That Acts via Rab11 in a Cdk5-Dependent Manner.

    • Author(s)
      Takano, T., Tomomura, M., Yoshioka, N., Tsutsumi, K., Terasawa, Y., Saito, T., Kawano, H., Kamiguchi, H., Fukuda, M., Hisanaga, S.
    • Journal Title

      J. Neurosci.

      Volume: (in press)

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Journal Article] Subcellular localization of active Cdk5 is determined by its own kinase activity.

    • Author(s)
      Asada, A., Saito, T., and Hisanaga, S.
    • Journal Title

      J. Cell Sci.

      Volume: (in press)

    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Cellular and in vivo function of LMTK1 in mouse neurons2023

    • Author(s)
      Hisanaga, S.
    • Organizer
      1st LMTK International Virtual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Presentation] The role of Cdk5 activity in valproic acid-induced anxiety- and depression-like behaviors.2021

    • Author(s)
      高橋美由紀、Ran Wei、安藤香奈絵、大島登志男、久永眞市
    • Organizer
      第64回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Presentation] GSK3bとタウのin vivoリン酸化のPhos-tag電気泳動法による解析2021

    • Author(s)
      久永眞市、木村妙子、Ambika Krishnankutty、 Nastaran Samimi
    • Organizer
      第72回日本電気泳動学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Presentation] Analysis of the phosphorylation of neurodegenerative disease protein Tau by Phos-tag phosphoaffinity SDS-PAGE.2021

    • Author(s)
      Shin-ichi Hisanaga, Taeko Kimura, Masato Hasegawa
    • Organizer
      The International Chemical Congress of Pacific Basin Societies
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Presentation] Distinct phosphorylation profiles of tau in brains of patients with different tauopathies2021

    • Author(s)
      Nastaran Samimi, Taeko Kimura, Tomoyasu Matsubara, Yuko Saito, Shigeo Murayama, Masato Hasegawa, Kanae Ando, Shin-ichi Hisanaga
    • Organizer
      第64回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Presentation] Hyperactive and impulsive behaviors of LMTK1 knockout mice2020

    • Author(s)
      Takahashi, M., Takahashi, R., Sugiyama, A., Kobayashi, S., Fukuda, K., Nishino, H., Wei, R., Kita, I., Ando, K., Manabe, T., Kamiguchi, H., Tomomura, M., Hisanaga, S.
    • Organizer
      第63回日本神経化学会年会
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Presentation] 脳に高発現するキナーゼLMTK1のアイソフォーム依存的な機能解析2020

    • Author(s)
      魏冉、西野尋紀、佐藤勇太、杉山亜梨華、高橋美由紀、浅田明子、福田光則、五十嵐道弘、友村美根子、久永真市
    • Organizer
      第63回日本神経化学会年会
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Presentation] Disease-dependent phosphorylation of tau in tauopathies2020

    • Author(s)
      Samimi, N., Sharma, G., Kimura, T., Huo, A., Chiba, K., Murayama, S., Akatsu, H., Hashizume, Y., Hasegawa, M., Farjam, M., Shahpasand, K., Ando, K., Hisanaga, S.
    • Organizer
      第63回日本神経化学会年会
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Presentation] Tau phosphorylation at AT8 pathological site during brain development.2019

    • Author(s)
      T. Dilina, K. Furusawa, T. Takasugi, S. Ishigaki, K. Ando, G. Sobue, S. Hisanaga.
    • Organizer
      ISN/ASN2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Presentation] Tau in marmoset brains, its isoform expression and phosphorylation.2019

    • Author(s)
      Sharma, G., Huo, A., Kimura, T., Shiozawa, S., Kobayashi, R., Sahara, N., Ishibashi, M., Ishigaki, S., Saito, T., Ando, K., Murayama, S., Hasegawa, H., Sobue, G., Okano, H., Hisanaga, S.
    • Organizer
      AD/PD 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Presentation] Tau in marmoset brains, its isoform expression and phosphorylation.2019

    • Author(s)
      Sharma, G., Huo, A., Kimura, T., Shiozawa, S., Kobayashi, R., Sahara, N., Ishibashi, M., Ishigaki, S., Saito, T., Ando, K., Murayama, S., Hasegawa, M., Sobue, G., Okano, H., Hisanaga, S.
    • Organizer
      AD/PD 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] CD2-associated protein (CD2AP) sorts amyloid precursor protein (APP) to late endosomes from early endosomes.2019

    • Author(s)
      Furusawa, K., Takasugi, T., Fukuda, M., Hisanaga, S.
    • Organizer
      AD/PD 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] CD2-associated protein (CD2AP) sorts amyloid precursor protein (APP) to late endosomes from early endosomes.2019

    • Author(s)
      Furusawa, K., Takasugi, T., Fukuda, M., Hisanaga, S.
    • Organizer
      AD/PD 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Presentation] Tau phosphorylation at AT8 pathological site during brain development.2019

    • Author(s)
      T. Dilina, K. Furusawa, T. Takasugi, S. Ishigaki, K. Ando, G. Sobue, S. Hisanaga.
    • Organizer
      Neuro2019
    • Data Source
      KAKENHI-PROJECT-19K06942
  • [Presentation] Lemur kinase 1 (LMTK1A) regulates dendritic spine formation through the TBC1D9B Rab11 GAP and Rab11 cascade.2018

    • Author(s)
      Nishino, H., Saito, T., Takano, T., Tsutsumi, K., Ando, K., Tomomura, M., Fukuda, M., Hisanaga, S.
    • Organizer
      第69回日本細胞生物学会
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Tau phosphorylation at AT8 pathological site during brain development(ポスター)2018

    • Author(s)
      Tuerde D, Furusawa K, Takasugi T, Kimura T, Ishigaki S, Ando K, Sobue G, Hisanaga SI.
    • Organizer
      The 48th Society for Neuroscience annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] In vitro disease modeling of the FTDP-17 TAU R406W mutation using patient-derived iPSCs.2018

    • Author(s)
      Nakamura M, Watanabe H, Shiozawa S, Maeda S, Hisanaga SI, Sahara N, Kimura T, Miyasaka T, Takashima A, Ikeuchi T, Okano H
    • Organizer
      Neuroscience 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Lemur kinase 1 (LMTK1) regulates dendritic spine formation through Rab11-dependent endosomal trafficking.2018

    • Author(s)
      Nishino, H., Saito, T., Ando, K., Tomomura, M., Fukuda, M., Hisanaga, S.
    • Organizer
      アメリカ神経科学会大会 (Neuroscience 2018)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] In vivo phosphorylation of tau in brains of Marmoset, a non-human Primate.2018

    • Author(s)
      Hisanaga, S., et al.
    • Organizer
      15 meeting of APSN
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07060
  • [Presentation] Cdk5-dependent phosphorylation of GRAB, a guanine nucleotide exchange factor for Rab8, regulates neuronal migration in the developing cerebral cortex.2018

    • Author(s)
      Furusawa, K., Asada, A., Urrutia, P., Gonzalez-Billault, C., Fukuda, M., Hisanaga, S.
    • Organizer
      ASCB/EMBO 2017 Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07060
  • [Presentation] 複雑怪奇なリン酸化タンパク質タウのPhos-tag解析2018

    • Author(s)
      木村妙子、久永眞市
    • Organizer
      電気泳動学会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07060
  • [Presentation] The role of Thr231 phosphorylation of tau on its localization into the nucleus.2018

    • Author(s)
      Zhu, Y., Kimura, T., Kikuchi, C., Wei, R., Ando, K., Hisanaga, S.
    • Organizer
      15th meeting of APSN
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] In vivo phosphorylation of tau in brains of Marmoset, a non-human Primate.2018

    • Author(s)
      Hisanaga, S., Shiozawa, S., Kobayashi, R., Murayama, S., Saito, T., Ando, K., Okano, H., Kimura, T., Sharma, G.
    • Organizer
      第61回日本神経化学会大会
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] アルツハイマー病危険因子CD2APはAPPの初期エンドソームから後期エンドソームへの輸送を促進する.2018

    • Author(s)
      Furusawa, K., Fukuda, M., Hisanaga, S.
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] エンドソームのトラッフィキング制御と軸索形成及び維持2018

    • Author(s)
      久永眞市
    • Organizer
      SAM研究会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07060
  • [Presentation] Cyclin-dependent kinase 5, its role in neuronal differentiation, synaptic activity and neurodegeneration.2018

    • Author(s)
      Hisanaga, S.
    • Organizer
      Royan International Conference
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07060
  • [Presentation] Phospho-tau bar code-死後脳でのタウリン酸化解析はタウオパチーの診断に役立つか?2018

    • Author(s)
      久永眞市
    • Organizer
      新学術領域研究「コホート・生体試料支援プラットフォーム」研究者対象シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07060
  • [Presentation] Cdk5-dependent phosphorylation of GRAB, a guanine nucleotide exchange factor for Rab8, regulates neuronal migration in the developing cerebral cortex.2017

    • Author(s)
      Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga S.
    • Organizer
      ASCB/EMBO 2017 Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] 複雑怪奇なリン酸化タンパク質タウのPhos-Tag解析2017

    • Author(s)
      木村妙子,久永眞市
    • Organizer
      第68回日本電気泳動学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Presentation] LMTK1 is a novel membrane bound kinase involved in anxiety and depression.2017

    • Author(s)
      Takahashi M, Sugiyama A, Takahashi R, Fukuda K, Tomomura M, Ando K, Hisanaga S.
    • Organizer
      ISN-ESN Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Cdk5 regulation of the GRAB-mediated Rab11-Rab8 cascade in axon outgrowth.2017

    • Author(s)
      Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga S.
    • Organizer
      第60回日本神経化学会
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] エンドソームのトラッフィキング制御と軸索形成及び維持2017

    • Author(s)
      久永眞市
    • Organizer
      SAM研究会シンポジウム
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] 複雑怪奇なリン酸化タンパク質タウのPhos-tag解析2017

    • Author(s)
      木村妙子、久永眞市
    • Organizer
      電気泳動学会シンポジウム
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Phospho-tau bar code-死後脳でのタウリン酸化解析はタウオパチーの診断に役立つか?2017

    • Author(s)
      久永眞市
    • Organizer
      新学術領域研究「コホート・生体試料支援プラットフォーム」研究者対象シンポジウム
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.2017

    • Author(s)
      Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, Hisanaga S.
    • Organizer
      The International Society of Neurochemistry (ISN) and the European Society for Neurochemistry (ESN)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Dendritic spine formation is regulated by Lemur kinase 1A (LMTK1A) via Rab11A-positive endosome trafficking.2017

    • Author(s)
      Nishino H, Takano T, Tsutsumi K, Asada A, Saito T, Ando K, Hisanaga S.
    • Organizer
      ISN-ESN Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] アルツハイマー型認知症関連因子βセクレターゼ(BACE1)の細胞内輸送におけるLemur kinase1A(LMTK1A)の役割2017

    • Author(s)
      駒木圭介、池田識人、佐藤裕、淺田明子、斉藤太郎、久永眞市
    • Organizer
      第40回日本分子生物学会
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Phosphorylation of serotonin 1A receptor (5HT1AR) by Cdk5.2017

    • Author(s)
      Takahashi M, Kobayashi Y, Ando K, Saito Y, Hisanaga S.
    • Organizer
      第60回日本神経化学会大会
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Cyclin-dependent kinase 5, its role in neuronal differentiation, synaptic activity and neurodegeneration.2017

    • Author(s)
      Hisanaga S.
    • Organizer
      Royan International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.2017

    • Author(s)
      Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, Hisanaga S.
    • Organizer
      Cell symposium: Big question in Neuroscience
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Ubiquitin-dependent and -independent degradation of p35 activation subunit of neuronal Cdk, Cdk5.2017

    • Author(s)
      Takasugi T, Minegishi S, Asada A, Saito T, Hiroyuki K, Hisanaga S.
    • Organizer
      Experimental Biology 2017 (Annual meeting of American Socity of Biochemistry and Molecullar Biology)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] In vivo regulation of GSK3b activity unveiled by the quantitative measurement of its phospho-isotypes2016

    • Author(s)
      Krishnankutty, K., Kimura, T., Saito, T., Aoyagi, K.,Asada, A., Ando, K., Ohara-Imaizumi, M., Ishiguro, K., Hisanaga, S.
    • Organizer
      46th annual meeting of Society for Neuroscience
    • Place of Presentation
      サンディエゴ、アメリカ
    • Year and Date
      2016-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07060
  • [Presentation] 樹状突起スパイン形成におけるLemur kinase1A(LMTK1A) の役割.2016

    • Author(s)
      西野尋紀, 堤弘次, 浅田明子, 斎藤太郎, 久永眞市
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-16K07060
  • [Presentation] In vivo regulation of GSK3b activity unveiled by the quantitative measurement of its phospho-isotypes.2016

    • Author(s)
      Krishnankutty K, Kimura T, Saito T, Aoyagi K, Asada A, Ando K, Ohara-Imaizumi M, Ishiguro K, Hisanaga S.
    • Organizer
      46th annual meeting of Society for Neuroscience
    • Place of Presentation
      サンディエゴ、アメリカ
    • Year and Date
      2016-11-12
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] βセクレターゼ(BACE1)の細胞内輸送におけるLemur kinase1(LMTK1)の役割2016

    • Author(s)
      駒木圭介、池田識人、高野哲也、友村美根子、淺田明子、斎藤太郎、安藤香奈絵、久永眞市
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] 樹状突起スパイン形成におけるLemur kinase1A(LMTK1A) の役割2016

    • Author(s)
      西野尋紀、堤弘次、浅田明子、斎藤太郎、久永眞市
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Phosphorylation and Isoform Expression of Microtubule-Associated Protein Tau are Regulated Independently during Brain Development.2016

    • Author(s)
      Tuerde D, Kimura T, Miyasaka T, Asada A, Saito1 T, Ando, K, Hisanaga S.
    • Organizer
      Asian-Pacific Society for Neurochemistry
    • Place of Presentation
      クアラルンプール、マレーシア
    • Year and Date
      2016-08-26
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Cdk5-dependent phosphorylation of GRAB, a guanine nucleotide exchange factor for Rab8, regulates axon outgrowth by directing Rab8A to Rab11A-positive endosomes.2016

    • Author(s)
      Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga S.
    • Organizer
      American Society for Cell Biology
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2016-12-03
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] 小胞体輸送を制御する脳キナーゼLMTK1の膜貫通型と非膜貫通型アイソフォームの発現と機能解析2016

    • Author(s)
      杉山亜梨華、高橋路佳、魏冉、福田公子、友村美根子、安藤香奈絵、久永眞市.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16K07060
  • [Presentation] Cdk5-dependent phosphorylation of GRAB, a guanine nucleotide exchange factor for Rab8, regulates axon outgrowth by directing Rab8A to Rab11A-positive endosomes.2016

    • Author(s)
      Furusawa, K., Asada, A., Urrutia, P., Gonzalez-Billault, C., Fukuda, M., Hisanaga, S
    • Organizer
      American Society for Cell Biology 20162016
    • Place of Presentation
      サンフランシスコ、アメリカ
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07060
  • [Presentation] Phosphorylation and Isoform Expression of Microtubule-Associated Protein Tau are Regulated Independently during Brain Development.2016

    • Author(s)
      Tuerde, D., Kimura, T., Miyasaka, T., Asada, A., Saito1, T.,Ando, K., Hisanaga, S.
    • Organizer
      14th Asian-Pacific Society for Neurochemistry
    • Place of Presentation
      クアラルンプール、マレーシア
    • Year and Date
      2016-08-26
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07060
  • [Presentation] Phos-tag SDS-PAGE法による神経変性疾患タウのリン酸化解析2015

    • Author(s)
      木村 妙子 久永 眞市
    • Organizer
      日本電気泳動学会
    • Place of Presentation
      東京、東京工科大学
    • Year and Date
      2015-09-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-25290024
  • [Presentation] 軸索伸長に関わる膜供給の新たな制御系―Cdk5によるGRAB(Rab8GEF)のリン酸化はRab8及びRab11を介して軸索伸長を制御する.2015

    • Author(s)
      古澤孝太郎, 淺田明子, 福田光則, 久永眞市.
    • Organizer
      第38回日本分子生物年会第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸、国際会議場
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25290024
  • [Presentation] GRAB, a GEF of Rab8, regulates axonal outgrowth in a Cdk5 phosphorylation-dependent manner.2015

    • Author(s)
      Furusawa, K., Asada, A., Fukuda, M., Hisanaga, S.
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      さいたま市、大宮ソニックシティー
    • Year and Date
      2015-09-11
    • Data Source
      KAKENHI-PROJECT-25290024
  • [Presentation] Reevaluation of physiological and pathological phosphorylation of tau in vitro to human brains2015

    • Author(s)
      Hisanaga, S., Kimura, T
    • Organizer
      25th International Society for Neurochemistry meeting
    • Place of Presentation
      Australia, Cairns
    • Year and Date
      2015-08-23
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25290024
  • [Presentation] Phosphorylation of serotonin 1A receptor (5HT1AR) by Cdk5 activity.2015

    • Author(s)
      Takahashi, M., and Hisanaga, S.
    • Organizer
      25th International Society for Neurochemistry meeting
    • Place of Presentation
      Australia, Cairns
    • Year and Date
      2015-08-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25290024
  • [Presentation] 脳特異的キナーゼCdk5の活性制御と生理および病理2014

    • Author(s)
      久永眞市
    • Organizer
      第4回メトロポリタン脳の老化・認知症ファーラム 特別講演
    • Place of Presentation
      東京
    • Year and Date
      2014-12-04
    • Invited
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] New aspects of tau phosphorylation obtained by Phos-tag SDS-PAGE.2014

    • Author(s)
      Kimura, T., Hosokawa, T., Tsutsumi, K., Masuda-Suzukake, M., Hosokawa, M., Ishiguro, K., Akiyama, H., Murayama, S., Hasegawa, M., Hisanaga, S.
    • Organizer
      第12回アジア太平洋神経化学会
    • Place of Presentation
      台湾
    • Year and Date
      2014-08-24
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] PP1-binding neuronal protein kinase LMTK1 suppresses neurite outgrowth through the regulation of Rab11-dependent endosomal trafficking.2014

    • Author(s)
      Takano, T., Tsutsumi, K., Fukuda, M., Tomomura, M., Hisanaga, S.
    • Organizer
      第11回国際フォスファターゼコンファレンス
    • Place of Presentation
      仙台市
    • Year and Date
      2014-11-13
    • Invited
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] New insights in tau phosphorylation obtained by Phos-tag SDS-PAGE analysis.2014

    • Author(s)
      Kimura, T., Hatsuta, H., Masuda-Suzukake, M., Ishiguro, K., Akiyama, H., Murayama, S., Hasegawa, M., Hisanaga, S.
    • Organizer
      第57回日本神経化学会大会
    • Place of Presentation
      奈良市
    • Year and Date
      2014-09-29
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] アミロイド前駆体タンパクAPPの細胞内輸送に対するCD2APおよびCIN85の役割2014

    • Author(s)
      金子秀一郎、浅田明子、斎藤太郎、久永真市
    • Organizer
      第37回日本分子生物学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-27
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] 微小管結合タンパク質タウのGSK3βによる生理的および病理的リン酸化のPhos-tag法を用いた再検証2014

    • Author(s)
      米澤遼、 網本紫、木村妙子、斎藤太郎、 久永眞市
    • Organizer
      第57回日本神経化学会
    • Place of Presentation
      奈良市
    • Year and Date
      2014-09-29
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Cdk5活性化因子p35のプロテアソーム分解について2014

    • Author(s)
      高杉俊之、嶺岸正治、小林弘侑、斎藤太郎、浅田明子、久永眞市.
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都市
    • Year and Date
      2014-10-18
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] The effect of Cyclin-dependent kinase 5 on voltage-dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state.2014

    • Author(s)
      Furusawa, K., Asada, A., Saito, T., Hisanaga, S.
    • Organizer
      第12回アジア太平洋神経化学会
    • Place of Presentation
      台湾
    • Year and Date
      2014-08-25
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Phosphorylation of Drebrin by Cyclin-dependent kinase 5 and Its Role in Neuronal Migration.2014

    • Author(s)
      Tanabe, K., Yamazaki, H., Inaguma, Y., Asada, A., Kimura, T., Takahashi, J., Taoka, M., Ohshima, T., Furuichi, T., Isobe, T., Nagata, K., Shirao, T., Hisanaga, S.
    • Organizer
      第12回アジア太平洋神経化学会
    • Place of Presentation
      台湾
    • Year and Date
      2014-08-25
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] 新規の神経セリン/スレオニンキナーゼ LMTK1 の新生ニューロンの移動や形態における役割2014

    • Author(s)
      漆原智己、高橋路佳、網本紫、高野哲也、土屋幸憲、斎藤太郎、友村美根子、久永眞市.
    • Organizer
      第37回日本分子生物学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-27
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] 電位依存性カルシウムチャネル活性に対するCdk5の影響2014

    • Author(s)
      古澤孝太郎、浅田明子、斎藤太郎、久永眞市
    • Organizer
      第57回日本神経化学会大会
    • Place of Presentation
      奈良市
    • Year and Date
      2014-09-30
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] 脳特異的キナーゼCdk5の活性制御と生理および病理2014

    • Author(s)
      久永眞市
    • Organizer
      第4回メトロポリタン脳の老化・認知症ファーラム
    • Place of Presentation
      東京
    • Year and Date
      2014-12-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-25290024
  • [Presentation] p39で活性化されるCdk5のRac1依存的ラメリポディアへの選択的集積2014

    • Author(s)
      淺田明子、伊藤有紀, 高野哲也, Sharma Govinda, 斉藤太郎, 太田安隆、天野睦紀, 貝淵弘三, 久永眞市.
    • Organizer
      第57回日本神経化学会大会
    • Place of Presentation
      奈良市
    • Year and Date
      2014-09-30
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Effect of valproic acid on Cdk5 activity and mouse behavior.2014

    • Author(s)
      Takahashi, M., Ishida, M., Saito, T., Ohshima, T., Hisanaga, S.
    • Organizer
      第12回アジア太平洋神経化学会
    • Place of Presentation
      台湾
    • Year and Date
      2014-08-24
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] Rab結合タンパク質GRABのCdk5-p35によるリン酸化とその役割2014

    • Author(s)
      古澤孝太郎、浅田明子、斎藤太郎、福田光則、久永眞市
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-27
    • Data Source
      KAKENHI-PLANNED-26117004
  • [Presentation] 神経細胞の軸索と樹状突起形成に関わる新たな膜輸送制御経路Cdk5-LMTK1-Rab112014

    • Author(s)
      久永眞市他
    • Organizer
      第86回日本生化学会大
    • Place of Presentation
      横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-25290024
  • [Presentation] Regulation of mitochondrial transport and inter-microtubule spacing by Tau phosphorylation at the sites hyperphosphorylated in Alzheimer’s disease.2013

    • Author(s)
      Hisanaga
    • Organizer
      第11回世界生物学的精神医学会国際会議
    • Place of Presentation
      京都
    • Invited
    • Data Source
      KAKENHI-PROJECT-25290024
  • [Presentation] LMTK1 regulates dendritic arborization by regulating movement of Rab11A-positive endosomes.2013

    • Author(s)
      Hisanaga et al.
    • Organizer
      The 43th annual meeting of the Society for Neuroscience.
    • Place of Presentation
      アメリカ・サンディエゴ
    • Data Source
      KAKENHI-PROJECT-25290024
  • [Presentation] Cdk5 and neuron cell death.2011

    • Author(s)
      Hisanaga, S., Asada, A., and Saito, T.
    • Organizer
      Pep Con-2010
    • Place of Presentation
      北京
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Phos-tag SDS-PAGEによって新しく出来たこと2011

    • Author(s)
      久永眞市
    • Organizer
      日本生化学会フォーラム
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Phos-tag SDS-PAGEによって新しく出来たこと2011

    • Author(s)
      久永眞市
    • Organizer
      日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Regulation of the kinase activity and function of Cyclin-dependent kinase 5 in post-mitotic neurons.2011

    • Author(s)
      Hisanaga, S.
    • Organizer
      第23回国際神経化学会シンポジウム
    • Place of Presentation
      アテネ
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Normal and abnormal phosphorylation of Tau by Cyclin-dependent kinase 52010

    • Author(s)
      Hisanaga, S.
    • Organizer
      Aging, Tau Protein and Dementias.
    • Place of Presentation
      東京
    • Year and Date
      2010-10-20
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] Normal and abnormal phosphorylation of Tau by Cyclin-dependent kinase 5.2010

    • Author(s)
      久永眞市
    • Organizer
      Aging, Tau Protein and Dementias.
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] Normal and abnormal phosphorylation of Tau by Cyclin-dependent kinase 5.2010

    • Author(s)
      Hisanaga, S.
    • Organizer
      Aging, Tau Protein and Dementias
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Cdk5 and neuron cell death.2010

    • Author(s)
      久永眞市
    • Organizer
      Pep Con-2010
    • Place of Presentation
      北京
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] Normal and abnormal phosphorylation of Tau by Cyclin-dependent kinase 5.2010

    • Author(s)
      Hisanaga, S.
    • Organizer
      Aging, Tau Protein and Dementias.
    • Place of Presentation
      東京
    • Year and Date
      2010-10-20
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] タンパク質リン酸化研究へのフォスタグSDS-PAGEの応用2009

    • Author(s)
      久永眞市
    • Organizer
      第4回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] Effect of PIN1 and microtubules binding on dephosphorylation of FTDP-17 mutant Tau.2009

    • Author(s)
      Hisanaga, S.
    • Organizer
      2009 International Conference on Alzheimer’s Disease
    • Place of Presentation
      ウィーン
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Neuronal development and neurodegeneration on Cdk5 and related signaling.2009

    • Author(s)
      久永眞市
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] サイクリン依存性キナーゼ5(Cdk5)の異常活性化と神経変性疾患2009

    • Author(s)
      久永眞市
    • Organizer
      「筋萎縮性側索硬化症の病態に基づく画期的治療法の開発」班のワークショップ
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] タンパク質リン酸化研究へのフォスタグSDS-PAGEの応用2009

    • Author(s)
      久永眞市, 細川智永, 浅田明子, 斎藤太郎
    • Organizer
      第4回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] dk5 and Microtubules in Neurodegenerative Diseases.2009

    • Author(s)
      Hisanaga, S.
    • Organizer
      The International Symposium on “Cell Cycle and Cell Architecture”
    • Place of Presentation
      名古屋
    • Year and Date
      2009-02-26
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Pro-survival and pro-apoptotic activity of neuron-specific protein kinase Cdk5.2009

    • Author(s)
      Hisanaga, S.
    • Organizer
      27th Annual conference of Indian Academy of Neuroscience
    • Place of Presentation
      インド
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Cdk5 and Neuron Cell Death.2009

    • Author(s)
      久永眞市
    • Organizer
      3^<rd> Annual Protein and Peptide Conference (PepCon-2010)
    • Place of Presentation
      北京
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] Effect of PIN1 and micro- tubules binding on dephosphorylation of FTDP-17 mutant Tau.2009

    • Author(s)
      Hisanaga, S.
    • Organizer
      International Conference on Alzheimer's Disease
    • Place of Presentation
      ウィーン
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Neuronal development and neurodegeneration on Cdk5 and related signaling2009

    • Author(s)
      Hisanaga, S
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] フォスタグSDS-PAGEを用いたタンパク質リン酸化の解析-Cdk5活性化サブユニットp35の場合-2009

    • Author(s)
      久永眞市
    • Organizer
      第7回ヒトプロテオーム学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] Pro-survival and pro-apoptotic activity of neuron-specific protein kinase Cdk5.2009

    • Author(s)
      久永眞市
    • Organizer
      27th Annual conference of Indian Academy of Neuroscience
    • Place of Presentation
      インド
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] フォスタグSDS-PAGEを用いたタンパク質リン酸化の解析-Cdk5活性化サブユニットp35の場合-2009

    • Author(s)
      久永眞市, 他3名
    • Organizer
      第7回日本ヒトプロテオーム学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-27
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Reconsideration of the activation mechanism of Cdk5 by p35 and p39.2009

    • Author(s)
      Hisanaga, S.
    • Organizer
      2^<nd> International Symposium on Cdk5
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] サイクリン依存性キナーゼ5の活性制御と神経変性疾患2009

    • Author(s)
      久永眞市
    • Organizer
      第31回日本分子生物学会シンポジウム
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] Cdk5 and Microtubules in Neurodegenerative Diseases.2009

    • Author(s)
      久永眞市
    • Organizer
      The International Symposium on "Cell Cycle and Cell Architecture".
    • Place of Presentation
      Nagoya
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] Reconsideration of the activation mechanism of Cdk5 by p35 and p39.2009

    • Author(s)
      久永眞市
    • Organizer
      2^<nd> International Symposium on Cdk5.
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] Effect of PIN1 and microtubules binding on dephosphorylation of FTDP-17 mutant Tau.2009

    • Author(s)
      久永眞市
    • Organizer
      2009 International Conference on Alzheimer's Disease.
    • Place of Presentation
      ウィーン
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] サイクリン依存性キナーゼ5の活性制御と神経変性疾患2008

    • Author(s)
      久永眞市, 淺田明子, 斎藤太郎
    • Organizer
      第31回日本分子生物学会シンポジウム
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] サイクリン依存性キナーゼ5の活性制御と神経変性疾患2008

    • Author(s)
      久永眞市、淺田明子、斎藤太郎
    • Organizer
      第31回日本分子生物学会シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Data Source
      KAKENHI-PROJECT-19044036
  • [Presentation] Filament assembly abnormality of neurofilament-L with Charcot-Marie-Tooth disease mutation.2008

    • Author(s)
      久永眞市
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] サイクリン依存性キナーゼ5の活性制御と神経変性疾患。2008

    • Author(s)
      久永眞市, 淺田明子, 斎藤太郎
    • Organizer
      第31回日本分子生物学会シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Data Source
      KAKENHI-PROJECT-20370047
  • [Presentation] サイクリン依存性キナーゼ5の活性制御と神経変性疾患2008

    • Author(s)
      久永眞市, 淺田明子, 斎藤太郎
    • Organizer
      第31回日本分子生物学会シンポジウム
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] 神経細胞の生死を決めるCdk5の膜結合と核移行2007

    • Author(s)
      久永 真市, ら
    • Organizer
      第30回分子生物学会ワークショップ
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2007-12-15
    • Data Source
      KAKENHI-PROJECT-18023030
  • [Presentation] 神経細胞の生死を決めるCdk5の膜結合と核移行2007

    • Author(s)
      久永真市, ら
    • Organizer
      第30回分子生物学会ワークショツプ
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2007-12-15
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] 神経細胞の生死を決めるCdk5の膜結合と核移行2007

    • Author(s)
      久永 真市, ら
    • Organizer
      第30回分子生物学会ワークショップ
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2007-12-15
    • Data Source
      KAKENHI-PROJECT-19044036
  • [Presentation] Filament assembly abnormality of neurofilament-L with Charcot-Marie-Tooth disease mutation2007

    • Author(s)
      Hisanaga, S., Gotow, T., Shiozaki, M., Sasaki, T., Asada, A., Saito, T., Uchiyama, Y., Yasuki, J.
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] 神経細胞の生死を決めるCdk5の膜結合と核移行2007

    • Author(s)
      久永真市, 浅田明子, 斉藤太郎
    • Organizer
      第30回分子生物学会ワークショップ
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] 神経細胞の生死を決めるCdk5の膜結合と核移行。2007

    • Author(s)
      久永真市, ら
    • Organizer
      第30回分子生物学会ワークショップ
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2007-12-15
    • Data Source
      KAKENHI-PROJECT-17300119
  • [Presentation] 神経細胞の生死を決めるCdk5の膜結合と核移行2007

    • Author(s)
      久永 真市, ら
    • Organizer
      第30回分子生物学会ワークショップ
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2007-12-15
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17300119
  • [Presentation] サイクリン依存性キナーゼ5(Cdk5)の異常活性化と神経変性疾患

    • Author(s)
      久永眞市
    • Organizer
      「筋萎縮性側索硬化症の病態に基づく画期的治療法の開発」班のワークショップ
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Neuronal development and neurodegeneration on Cdk5 and related signaling.

    • Author(s)
      Hisanaga, S.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] PP1-binding neuronal protein kinase LMTK1 suppresses neurite outgrowth through the regulation of Rab11-dependent endosomal trafficking

    • Author(s)
      Hisanaga, S.
    • Organizer
      第11回国際フォスファターゼコンファレンス
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-12 – 2014-11-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-25290024
  • [Presentation] フォスタグSDS-PAGEを用いたタンパク質リン酸化の解析-Cdk5活性化サブユニットp35の場合-

    • Author(s)
      久永眞市, 細川智永, 浅田明子, 斎藤太郎
    • Organizer
      第7回ヒトプロテオーム学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] アルツハイマー病でみられるタウの異常リン酸化とプロテインフォスファターゼ

    • Author(s)
      久永眞市, 斎藤太郎
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Neuronal development and neurodegeneration on Cdk5 and related signaling.

    • Author(s)
      Hisanaga, S.
    • Organizer
      第32回日本神経科学大会シンポジウム
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PLANNED-19057007
  • [Presentation] Analysis of tau phosphorylation in Tauopathy using Phos-tag SDS-PAGE.

    • Author(s)
      Kimura, T., Hisanaga, S.
    • Organizer
      日本神経病理学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-05 – 2014-06-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-25290024
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