Kitamoto Tetsuyuki 北本哲之

… Alternative Names

Researcher Number	20192560
Other IDs
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Affiliation (Current)	2021: 東北大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2020: 東北大学, 医学系研究科, 教授 2012 – 2015: 東北大学, 医学(系)研究科(研究院), 教授 2010 – 2012: 東北大学, 大学院・医学系研究科, 教授 2007 – 2008: Tohoku University, 大学院・医学系研究科, 教授 2006: 東北大学, 大学院医学系研究科, 教授 … More
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / Neurology / Neurology / Experimental pathology / Medium-sized Section 52:General internal medicine and related fields / Virology / Nerve anatomy/Neuropathology / Basic Section 52020:Neurology-related Except Principal Investigator Biological Sciences / Neurology … More
Keywords	Principal Investigator プリオン / プリオン蛋白 / クロイツフェルト・ヤコブ病 / トランスジェニックマウス / prion protein / ノックインマウス / 遺伝子置換 / 感染実験 / FFI / Creutzfeldt-Jakob disease … More Except Principal Investigator プリオン / クロイツフェルト・ヤコブ病 / プリオン蛋白 / CJD / 神経変性 / アミロイド / プリオン病 / コンフォメーション / 変異 / トランスジェニックマウス / prion protein / Creutzfeldt-Jakob disease / 濾胞樹状細胞 / アルツハイマー病 / バイオアッセイ / prion / bioassay / マウス / tau / SCIDマウス / 遺伝子治療 / GPIアンカー / polymorphism / プリオン蛋白遺伝子 / PHFtau / Alzheimer's disease / 血液 / 感染性 / blood / 軸策内輸送 / コルヒチン / IDPN / PHF / βタンパク / リン酸化 / CJD感受性 / 脾細胞 / ブリオン / 実験的治療 / ペントサンポリサルフェート / 脳室内持続注入 / 国際会議 / トランスレーショナルリサーチ / 公開講座 / 包括的治療 / タウ / αシヌクレイン / TDP-43 / C9ORF72 / 伝播 / 感染 / 前頭側頭葉変性症 / プログラニュリン / 神経変性疾患 / 脳神経疾患 / APP / ゲルストマン・ストロイスラ-症候群 / 多形性 / 多型性 / Creutzfeld-Jakob disease / Gerstmann-Straussler syndrome / モデル動物 / コンジェニック / 濾胞樹伏細胞 / 戻し交配 / PCR法 / 遺伝子診断 / コンジェニックマウス / animal model / Creutzfeldt-Jakob disease(CJD) / prion disease / congenic mouse / SCID mouse / follicular dendritic cell(FDC) / Creutzfeldt-Jakob / follicular dendritic cell / 無酸素脳症 / 磁気共鳴画像 / 病理 / 層状壊死 / 磁気共鳴画像(MRI) / 低酸素脳症 / 皮質の層状壊死 / 剖検脳 / 組織学的所見 / 虚血性変化 / Anoxic brain damage / Magnetic resonance / Pathology / Laminar necrosis / 痴呆 / アポリポ蛋白E / 分子生物学 / 前頭側頭型痴呆 / ピック病 / 前頭-側頭型痴呆 / dementia / apolipoproteinE / molecular biology / frontotemporal dementia / Pick's desease / 伝達性海綿状脳症 / スクレイピー / 神経疾患 / スクレイピ- / 牛海綿状脳症 / scrapie / transmissible spongiform encephalopath / neurological diseases / prion diseases / 神経原線維変化 / τ蛋白 / PHFτ / tau蛋白 / タウ蛋白 / トランスジェニック / neurofibrillary tangles / 遺伝子導入マウス / プリオン感染 / ヒト化モデル / 感染力価 / follicular dendritic cells / knock-in mouse / prions / conformation / mutation / gene therapy / amyloid / neuronal degeneration / transgenic mice / CJD患者 / 感染症 / プリオン感染力価 / infectivity / 多形 / 硬膜移植 / 異常プリオン蛋白 / サブタイプ / dura mater grafting / abnormal isoform / subtype / アルツハイマ-病 / β蛋白 / 老年痴呆 / beta-protein / 試験管内増幅 / 獲得型CJD / 医原性プリオン病 / PMCA / in vitro / 医原性クロイツフェルトヤコブ病 Less

視床型クロイツフェルト・ヤコブ病の新しい分類法の樹立Principal InvestigatorOngoing
- Principal Investigator
  
  北本哲之
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tohoku University
FFI SFIに見られる新しいプリオンの同定と新分類の確立のための国際共同研究Principal InvestigatorOngoing
- Principal Investigator
  
  北本哲之
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tohoku University
各種プリオンによる末梢からの感染力評価法の樹立Principal InvestigatorOngoing
- Principal Investigator
  
  北本哲之
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tohoku University
Rapid diagnosis of aqcuired Creutzfeldt-jakob disease with protein misfolding cyclic anplification
- Principal Investigator
  
  Takeuchi Atsuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Molecular bases of pathogenic proteins and mechanisms of the propagation
- Principal Investigator
  
  HASEGAWA Masato
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Is thalamic CJD a sporadic form of fatal familial insomnia?Principal Investigator
- Principal Investigator
  
  Kitamoto Tetsuyuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Study for highly sensitive PMCA amplification with vCJD prionsPrincipal Investigator
- Principal Investigator
  
  KITAMOTO TETSUYUKI
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
new classification of sporadic CJD with MV2.Principal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
To establish a rapid diagnostic test in a vCJD patient with Codon 129 Val/ValPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
To study the molecular mechanism of prion protein conversionPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Study of the pathomechanism in the prion infectionPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
ヤコブ病に対する実験的治療法に関する国際連絡会議の企画
- Principal Investigator
  
  堂浦克美
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
プリオン蛋白の神経障害機構とGPIアンカーの役割
- Principal Investigator
  
  村本環
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
プリオン蛋白の神経障害機構とGPIアンカーの役割
- Principal Investigator
  
  村本環
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Analysis of the influence of residue 219 polymorphism of prion protein on human prion diseases
- Principal Investigator
  
  MURAMOTO Tamaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tohoku University
変異プリオン蛋白のプリオン増殖抑制効果とその遺伝子治療への応用
- Principal Investigator
  
  MURAMOTO Tamaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
プリオン蛋白特異的モノクローナル抗体を用いたプリオン病の血清学的診断方法の確立Principal Investigator
- Principal Investigator
  
  北本哲之
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Virology
- Research Institution
  Tohoku University
Transmission experiment of the model mouse expressed with the secretary from of the prion proteinPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
Bioassay for human prions with the follicular dendritic cellsPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Detection of prion infectivity of vibrinogen in human blood
- Principal Investigator
  
  MOURI Shirou
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyushu University
Analyois of infectivity in the blood from patients with prion disease
- Principal Investigator
  
  MURAMOTO Tamaki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Analyses of prion structure using deletion mutants of prion protein
- Principal Investigator
  
  MURAMOTO Tamaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
Cellular Distribution of Prion ProteinPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  TOHOKU UNIVERSITY
家族制アルツハイマー病原因遺伝子presenilin-1結合因子の探索Principal Investigator
- Principal Investigator
  
  北本哲之
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
Molecular pathogenesis of transmissible spongiform encephalopathy
- Principal Investigator
  
  YAMANOUCHI Kazuya
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Institution
  Nippon Institute for Biological Science
Transmission Experiment with transgenic modelPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  TOHOKU UNIVERSITY
種特異的プリオン蛋白結合因子の同定Principal Investigator
- Principal Investigator
  
  北本哲之
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
A production of animal model for neurofibrillary tangles of Alzheimer's disease
- Principal Investigator
  
  SHIN Ryoung-Woon
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
ヒトプリオン蛋白過剰発現モデルの確立Principal Investigator
- Principal Investigator
  
  北本哲之
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
ApolipoproteinE gene polymorphism in frontotemporal dementia in Japan
- Principal Investigator
  
  OGOMORI Koji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  KYUSHU UNIVERSITY
アルツハイマー病脳内蓄積物質の形成機序
- Principal Investigator
  
  井原康夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
SCIDマウスにおけるプリオン病耐性のメカニズム
- Principal Investigator
  
  毛利資郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  佐賀医科大学
The establishment of prion protein humanaized mice using homologous recombinationPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki, 立石潤
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
  Kyushu University
Hypoxic brain damage : MR imaging findings and its correlation with histological findings
- Principal Investigator
  
  TAKAHASHI Shoki
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
CJD感染因子の軸索内輸送と濾胞樹状細胞の役割
- Principal Investigator
  
  MOHRI Shirou
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  佐賀医科大学
Study on pathologic mechanism of wild or mutant prion protein gene.Principal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  KYUSHU UNIVERSITY
Study on the mechanism of prion protein accumulations in follicular dendritic cells.
- Principal Investigator
  
  TATEISHI Jun
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  KYUSHU UNIVERSITY
Identification of synaptic accumulation of prion proten in Creutzfeldt-Jakob disease.Principal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  KYUSHU UNIVERSITY
Studies on polymorphism of the prion protein gene in familial Creutzfeldt-Jakob disease.
- Principal Investigator
  
  TATEISHI Jun
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kyusyu University
Development of a congenic strain on the mouse prion protein gene
- Principal Investigator
  
  HANDA Sumio
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  KYUSHU UNIVERSITY
Establishment of Prion Protein Immunoassay for Creutzfeldt-Jakob Disease.Principal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyushu University
Comparative study on cerebral amyloids of senile dementia and Creutzfeldt-Jakob disease.
- Principal Investigator
  
  TATEISHI Jun
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University

[Journal Article] A case of M232R genetic Creutzfeldt-Jakob disease with Lewy bodies2020
- Author(s)
  Akagi Akio、Iwasaki Yasushi、Hashimoto Rina、Aiba Ikuko、Inukai Akira、Mimuro Maya、Riku Yuichi、Miyahara Hiroaki、Kitamoto Tetsuyuki、Yoshida Mari
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 409 Pages: 116605-116605
- DOI
  10.1016/j.jns.2019.116605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] Eliminating transmissibility of bovine spongiform encephalopathy by dry-heat treatment2020
- Author(s)
  Matsuura Yuichi、Ishikawa Yukiko、Murayama Yuichi、Yokoyama Takashi、Somerville Robert A.、Kitamoto Tetsuyuki、Mohri Shirou
- Journal Title
  
  Journal of General Virology
  
  Volume: 101 Pages: 136-142
- DOI
  10.1099/jgv.0.001335
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] Correlating diffusion-weighted MRI intensity with type 2 pathology in mixed MM-type sporadic Creutzfeldt-Jakob disease.2020
- Author(s)
  Ikeda Toshimasa、Iwasaki Yasushi、Sakurai Keita、Akagi Akio、Riku Yuichi、Mimuro Maya、Miyahara Hiroaki、Kitamoto Tetsuyuki、Matsukawa Noriyuki、Yoshida Mari
- Journal Title
  
  J Neurol Sci.
  
  Volume: 408 Pages: 116515-116515
- DOI
  10.1016/j.jns.2019.116515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-17K09761
[Journal Article] The characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins2019
- Author(s)
  Rossi Marcello、Kai Hideaki、Baiardi Simone、Bartoletti-Stella Anna、Carla Benedetta、Zenesini Corrado、Capellari Sabina、Kitamoto Tetsuyuki、Parchi Piero
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 7 Pages: 53-53
- DOI
  10.1186/s40478-019-0706-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] A novel combination of prion strain co-occurrence in patients with sporadic Creutzfeldt-Jakob disease.2019
- Author(s)
  Kobayashi Atsushi、Iwasaki Yasushi、Takao Masaki、Saito Yuko、Iwaki Toru、Qi Zechen、Torimoto Ryouta、Shimazaki Taishi、Munesue Yoshiko、Isoda Norikazu、Sawa Hirofumi、Aoshima Keisuke、Kimura Takashi、Kondo Hinako、Mohri Shirou、Kitamoto Tetsuyuki
- Journal Title
  
  American Journal of Pathology
  
  Volume: 印刷中 Pages: 1276-1283
- DOI
  10.1016/j.ajpath.2019.02.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18K06506, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02738
[Journal Article] Intermolecular crosslinking of abnormal prion protein is efficiently induced by a primuline-sensitized photoreaction.2019
- Author(s)
  Teruya Kenta、Nishizawa Keiko、Oguma Ayumi、Sakasegawa Yuji、Kitamoto Tetsuyuki、Doh-ura Katsumi
- Journal Title
  
  Biochim Biophys Acta Gen Subj
  
  Volume: 1863 Pages: 384-394
- DOI
  10.1016/j.bbagen.2018.11.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07518, KAKENHI-PROJECT-17K19540, KAKENHI-PROJECT-16H05317, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22479
[Journal Article] An autopsied case of MM1-type sporadic Creutzfeldt- Jakob disease with pathology of Wernicke encephalopathy2019
- Author(s)
  Iwasaki Y, Hashimoto R, Saito Y, Aiba I, Inukai A, Akagi A, Mimuro M, Miyahara H, Kitamoto T, Yoshida M
- Journal Title
  
  Prion
  
  Volume: 13(1) Pages: 13-20
- DOI
  10.1080/19336896.2018.1545525
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02738
[Journal Article] Correction to: In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation.2019
- Author(s)
  Wang Z, Yuan J, Shen P, Abskharon R, Lang Y, Dang J, Adornato A, Xu L, Chen J, Feng J, Moudjou M, Kitamoto T, Lee HG, Kim YS, Langeveld J, Appleby B, Ma J, Kong Q, Petersen RB, Zou WQ, Cui L
- Journal Title
  
  Mol Neurobiol
  
  Volume: 56 Pages: 5470-5470
- DOI
  10.1007/s12035-019-1508-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] Autopsy case of MV2K‐type sporadic Creutzfeldt‐Jakob disease with spongiform changes of the cerebral cortex2019
- Author(s)
  Iwasaki Yasushi、Hiraga Keita、Ito Shota、Ando Tetsuo、Akagi Akio、Riku Yuichi、Mimuro Maya、Miyahara Hiroaki、Kobayashi Atsushi、Kitamoto Tetsuyuki、Yoshida Mari
- Journal Title
  
  Neuropathology
  
  Volume: 39 Pages: 452-460
- DOI
  10.1111/neup.12595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] Autopsied case of sporadic Creutzfeldt‐Jakob disease classified as MM1+2C‐type2019
- Author(s)
  Iwasaki Y, Kato H, Ando T, Akagi A, Mimuro M, Miyahara H, Kobayashi A, Kitamoto T, Yoshida M.
- Journal Title
  
  Neuropathology
  
  Volume: 印刷中 Pages: 240-247
- DOI
  10.1111/neup.12557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] Clinicopathological findings of an MM2-cortical-type sporadic Creutzfeldt-Jakob disease patient with cortical blindness during a course of glaucoma and age-related macular degeneration2019
- Author(s)
  Hayashi Yuichi、Iwasaki Yasushi、Waza Masahiro、Shibata Hideaki、Akagi Akio、Kimura Akio、Inuzuka Takashi、Satoh Katsuya、Kitamoto Tetsuyuki、Yoshida Mari、Shimohata Takayoshi
- Journal Title
  
  Prion
  
  Volume: 13 Pages: 124-131
- DOI
  10.1080/19336896.2019.1631680
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] Age at onset in genetic prion disease and the design of preventive clinical trials2019
- Author(s)
  Minikel Eric Vallabh、Kitamoto Tetsuyuki、Mead Simon、et al(32人,18番目)
- Journal Title
  
  Neurology
  
  Volume: 93
- DOI
  10.1212/wnl.0000000000007745
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-17H04194, KAKENHI-PROJECT-18H02738
[Journal Article] In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation2019
- Author(s)
  Wang Z, Yuan J, Shen P, Abskharon R, Lang Y, Dang J, Adornato A, Xu L, Chen J, Feng J, Moudjou M, Kitamoto T, Langeveld J, Appleby B, Ma J, Kong Q, Petersen RB, Zou WQ, Cui L
- Journal Title
  
  Mol Neurobiol
  
  Volume: -
- DOI
  10.1007/s12035-018-1459-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02738
[Journal Article] A domain responsible for spontaneous conversion of bank vole prion protein.2019
- Author(s)
  Kobayashi Atsushi、Matsuura Yuichi、Takeuchi Atsuko、Yamada Masahito、Miyoshi Ichiro、Mohri Shirou、Kitamoto Tetsuyuki
- Journal Title
  
  Brain Pathol
  
  Volume: 29 Pages: 155-163
- DOI
  10.1111/bpa.12638
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18K07490, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-17K07129
[Journal Article] Ganglioside synthase knock-out reduces prion disease incubation time in mouse models2019
- Author(s)
  Kobayashi Atsushi、Qi Zechen、Shimazaki Taishi、Munesue Yoshiko、Miyamoto Tomomi、Isoda Norikazu、Sawa Hirofumi、Aoshima Keisuke、Kimura Takashi、Mohri Shirou、Kitamoto Tetsuyuki、Yamashita Tadashi、Miyoshi Ichiro
- Journal Title
  
  Am J Pathol.
  
  Volume: 189 Pages: 677-686
- DOI
  10.1016/j.ajpath.2018.11.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-17K07129
[Journal Article] Autopsy case of V180I genetic Creutzfeldt-Jakob disease presenting with early disease pathology2018
- Author(s)
  Iwasaki Y, Kato H, Ando T, Akagi A, Mimuro M, Miyahara H, Kitamoto T, Yoshida M
- Journal Title
  
  Neuropathology
  
  Volume: 38(6) Pages: 638-645
- DOI
  10.1111/neup.12516
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02738
[Journal Article] Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study2018
- Author(s)
  Cali I, Cohen ML, Haik S, Parchi P, Giaccone G, Collins SJ, Kofskey D, Wang H, McLean CA, Brandel JP, Privat N, Sazdovitch V, Duyckaerts C, Kitamoto T, et al
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 6 Pages: 5-5
- DOI
  10.1186/s40478-017-0503-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738
[Journal Article] Pathological progression of genetic Creutzfeldt-Jakob disease with a PrP V180I mutation.2018
- Author(s)
  Akagi A, Iwasaki Y, Mimuro M, Kitamoto T, Yamada M, Yoshida M.
- Journal Title
  
  Prion
  
  Volume: 12 Pages: 54-62
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117005
[Journal Article] An autopsy report of three kindred in a Gerstmann-Sträussler-Scheinker disease P105L family with a special reference to prion protein, tau, and beta-amyloid2018
- Author(s)
  Ishizawa Keisuke、Mitsufuji Takashi、Shioda Kei、Kobayashi Atsushi、Komori Takashi、Nakazato Yoshihiko、Kitamoto Tetsuyuki、Araki Nobuo、Yamamoto Toshimasa、Sasaki Atsushi
- Journal Title
  
  Brain Behav
  
  Volume: 8
- DOI
  10.1002/brb3.1117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18H02738
[Journal Article] Neuroimaging-pathological correlations of [18F]THK5351 PET in progressive supranuclear palsy.2018
- Author(s)
  Ishiki A, Harada R, Kai H, Sato N, Totsune T, Tomita N, Watanuki S, Hiraoka K, Ishikawa Y, Funaki Y, Iwata R, Furumoto S, Tashiro M, Sasano H, Kitamoto T, Kudo Y, Yanai K, Furukawa K, Okamura N, Arai H.
- Journal Title
  
  Acta Neuropathol Commun.
  
  Volume: 6 Pages: 53-53
- DOI
  10.1186/s40478-018-0556-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-16H05383, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-16K15570, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003
[Journal Article] Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures: a case report and literature review2018
- Author(s)
  Miyake K, Hara T, Oshima E, Kawada K, Ishizu H, Yamauchi Y, Satoh K, Kitamoto T, Takenoshita S, Terada S, Yamada N
- Journal Title
  
  BMC Neurol
  
  Volume: 18(1) Pages: 54-54
- DOI
  10.1186/s12883-018-1055-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09759, KAKENHI-PROJECT-18H02738
[Journal Article] Specific amyloid-β42 deposition in the brain of a Gerstmann-Straussler-Scheinker disease patient with a P105L mutation on the prion protein gene2018
- Author(s)
  Furukawa F, Sanjo N, Kobayashi A, Hamaguchi T, Yamada M, Kitamoto T, Mizusawa H, Yokota T
- Journal Title
  
  Prion
  
  Volume: 12 Pages: 315-319
- DOI
  10.1080/19336896.2018.1541689
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09752, KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18H02738
[Journal Article] Autopsied case of non-plaque-type dura mater graft-associated Creutzfeldt-Jakob disease presenting with extensive amyloid-β deposition2018
- Author(s)
  Iwasaki Y, Imamura K, Iwai K, Kobayashi Y, Akagi A, Mimuro M, Miyahara H, Kitamoto T, Yoshida M
- Journal Title
  
  Neuropathology
  
  Volume: 38(5) Pages: 549-556
- DOI
  10.1111/neup.12503
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02738
[Journal Article] Pathological progression of genetic Creutzfeldt-Jakob disease with a PrP V180I mutation2018
- Author(s)
  Akagi A, Iwasaki Y, Mimuro M, Kitamoto T, Yamada M, Yoshida M.
- Journal Title
  
  Prion
  
  Volume: 12 Pages: 54-62
- DOI
  10.1080/19336896.2017.1414130
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-18H02738
[Journal Article] PrPres deposition in the retina is a common finding of sporadic, familial and iatrogenic Creutzfeldt-Jakob diseases(CJD)2018
- Author(s)
  Takao M, Kimura H, Kitamoto T, Mihara B.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 6 Pages: 78-78
- DOI
  10.1186/s40478-018-0582-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06506, KAKENHI-PROJECT-18H02738
[Journal Article] Biochemical features of genetic Creutzfeldt-Jakob disease with valine-to-isoleucine substitution at codon 180 on the prion protein gene.2018
- Author(s)
  Ito Yoko、Sanjo Nobuo、Hizume Masaki、Kobayashi Atsushi、Ohgami Tetsuya、Satoh Katsuya、Hamaguchi Tsuyoshi、Yamada Masahito、Kitamoto Tetsuyuki、Mizusawa Hidehiro、Yokota Takanori
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 496 Pages: 1055-1061
- DOI
  10.1016/j.bbrc.2018.01.119
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18790, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738
[Journal Article] Iatrogenic Creutzfeldt-Jakob disease2018
- Author(s)
  Kobayashi A, Kitamoto T, Mizusawa H
- Journal Title
  
  Handb Clin Neurol
  
  Volume: 153 Pages: 207-218
- DOI
  10.1016/b978-0-444-63945-5.00012-x
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02738
[Journal Article] Development of a quick bioassay for the evaluation of transmission properties of acquired prion diseases2018
- Author(s)
  Munesue Y, Shimazaki T, Qi Z, Isoda N, Sawa H, Aoshima K, Kimura T, Mohri S, Kitamoto T, Kobayashi A
- Journal Title
  
  Neurosci Lett
  
  Volume: 668 Pages: 43-47
- DOI
  10.1016/j.neulet.2018.01.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-16K18790, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738
[Journal Article] Application of protein misfolding cyclic amplification for the rapid diagnosis of acquired Creutzfeldt-Jakob disease2017
- Author(s)
  Takeuchi A, Kobayashi A, Morita M, Kitamoto T
- Journal Title
  
  Medical Research Archives
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09307
[Journal Article] An autopsied case of MM1 + MM2-cortical with thalamic-type sporadic Creutzfeldt-Jakob disease presenting with hyperintensities on diffusion-weighted MRI before clinical onset.2017
- Author(s)
  Iwasaki Y, Mori K, Ito M, Mimuro M, Kitamoto T, Yoshida M.
- Journal Title
  
  Neuropathology
  
  Volume: 37(1) Pages: 78-85
- DOI
  10.1111/neup.12327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-15K08369
[Journal Article] Application of protein misfolding cyclic amplification for the rapid diagnosis of acquired Creutzfeldt-Jakob disease.2017
- Author(s)
  Takeuchi A, Kobayashi A, Morita M, Kitamoto T
- Journal Title
  
  Medical Research Archives
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09307
[Journal Article] Specific clinical signs and symptoms are predictive of clinical course in sporadic Creutzfeldt-Jakob disease.2016
- Author(s)
  Nakatani E, Kanatani Y, Kaneda H, Nagai Y, Teramukai S, Nishimura T, Zhou B, Kojima S, Kono H, Fukushima M, Kitamoto T, Mizusawa H.
- Journal Title
  
  Eur J Neurol.
  
  Volume: 23(9) Pages: 1455-62
- DOI
  10.1111/ene.13057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506
[Journal Article] Distinctive properties of plaque-type dura mater graft-associated Creutzfeldt-Jakob disease in cell-protein misfolding cyclic amplification.2016
- Author(s)
  Atsuko Takeuchi, Atsushi Kobayashi, Piero Parchi, Masahito Yamada, Masanori Morita, Shusei Uno and Tetsuyuki Kitamoto
- Journal Title
  
  Lab Invest
  
  Volume: in press Pages: 581-587
- DOI
  10.1038/labinvest.2016.27
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09307, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-16K18790
[Journal Article] Efficient propagation of variant Creutzfeldt-Jakob disease prion protein using the cell-protein misfolding cyclic amplification technique with samples containing plasma and heparin.2016
- Author(s)
  Oshita M, Yokoyama T, Takei Y, Takeuchi A, Ironside JW, Kitamoto T, Morita M.
- Journal Title
  
  Transfusion.
  
  Volume: 56(1) Pages: 223-30
- DOI
  10.1111/trf.13279
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-25257506
[Journal Article] An autopsy-verified case of FTLD-TDP type A with upper motor neuron-predominant motor neuron disease mimicking MM2-thalamic-type sporadic Creutzfeldt-Jakob disease.2016
- Author(s)
  Hayashi Y, Iwasaki Y, Takekoshi A, Yoshikura N, Asano T, Mimuro M, Kimura A, Satoh K, Kitamoto T, Yoshida M, Inuzuka T.
- Journal Title
  
  Prion
  
  Volume: 10(6) Pages: 492-501
- DOI
  10.1080/19336896.2016.1243192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26460861
[Journal Article] Significant association of cadaveric dura mater grafting with subpial Abeta deposition and meningeal amyloid angiopathy.2016
- Author(s)
  Hamaguchi T, Taniguchi Y, Sakai K, Kitamoto T, Takao M, Murayama S, Iwasaki Y, Yoshida M, Shimizu H, Kakita A, Takahashi H, Suzuki H, Naiki H, Sanjo N, Mizusawa H, Yamada M
- Journal Title
  
  Acta Neuropathol
  
  Volume: 132(2) Pages: 313-315
- DOI
  10.1007/s00401-016-1588-3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-26430060, KAKENHI-PROJECT-26860234, KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-16H06277
[Journal Article] Neuropathological and biochemical criteria to identify acquired Creutzfeldt-Jakob disease among presumed sporadic cases2016
- Author(s)
  Kobayashi A, Parchi P, Yamada M, Mohri S, Kitamoto T.
- Journal Title
  
  Neuropathology
  
  Volume: - Pages: 305-310
- DOI
  10.1111/neup.12270
- NAID
  120006219897
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-16K18790
[Journal Article] Sporadic Creutzfeldt-Jakob disease MM1+2C and MM1 are identical in transmission properties.2016
- Author(s)
  Kobayashi A, Matsuura Y, Iwaki T, Iwasaki Y, Yoshida M, Takahashi H, Murayama S, Takao M, Kato S, Yamada M, Mohri S, Kitamoto T.
- Journal Title
  
  Brain Pathol.
  
  Volume: in press Pages: 95-101
- DOI
  10.1111/bpa.12264
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-26430060, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-25257506
[Journal Article] Preserved regional cerebral blood flow in the occipital cortices, brainstem, and cerebellum of patients with V180I-129M genetic Creutzfeldt-Jakob disease in serial SPECT studies.2016
- Author(s)
  Hayashi Y, Yoshikura N, Takekoshi A, Yamada M, Asano T, Kimura A, Satoh K, Kitamoto T, Inuzuka T.
- Journal Title
  
  J Neurol Sci
  
  Volume: 370 Pages: 145-151
- DOI
  10.1016/j.jns.2016.09.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26460861
[Journal Article] Quantifying prion disease penetrance using large population control cohorts.2016
- Author(s)
  Minikel EV, Vallabh SM, Lek M, Estrada K, Samocha KE, et al
- Journal Title
  
  Sci Transl Med.
  
  Volume: 8
- DOI
  10.1126/scitranslmed.aad5169
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-25257506
[Journal Article] Analysis of Conformational Stability of Abnormal Prion Protein Aggregates across the Spectrum of Creutzfeldt-Jakob Disease Prions.2016
- Author(s)
  Cescatti M, Saverioni D, Capellari S, Tagliavini F, Kitamoto T, Ironside J, Giese A, Parchi P.
- Journal Title
  
  J Virol.
  
  Volume: 90(14) Pages: 6244-54
- DOI
  10.1128/jvi.00144-16
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25257506
[Journal Article] Factors influencing the survival period in Japanese patients with sporadic Creutzfeldt-Jakob disease.2015
- Author(s)
  Iwasaki Y, Akagi A, Mimuro M, Kitamoto T, Yoshida M.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 357 Pages: 63-8
- DOI
  10.1016/j.jns.2015.06.065
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Decreased regional cerebral blood flow in the bilateral thalami and medulla oblongata determined by an easy Z-score (eZIS) analysis of 99mTc-ECD-SPECT images in a case of MM2-thalamic-type sporadic Creutzfeldt-Jakob disease.2015
- Author(s)
  Hayashi Y, Iwasaki Y, Yoshikura N, Asano T, Hatano T, Tatsumi S, Satoh K, Kimura A, Kitamoto T, Yoshida M, Inuzuka T.
- Journal Title
  
  Journal of Neurological Science
  
  Volume: 358 Pages: 447-452
- DOI
  10.1016/j.jns.2015.09.356
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-26461290, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-25461290, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-26305030
[Journal Article] Transmission properties of atypical Creutzfeldt-Jakob disease: a clue to disease etiology?2015
- Author(s)
  Kobayashi A, Parchi P, Yamada M, Brown P, Saverioni D, Matsuura Y, Takeuchi A, Mohri S, Kitamoto T
- Journal Title
  
  J Virol.
  
  Volume: 89(7) Pages: 3939-46
- DOI
  10.1128/jvi.03183-14
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435, KAKENHI-PLANNED-26117005
[Journal Article] Descriptive Epidemiology of Prion Disease in Japan: 1999–20122015
- Author(s)
  Nakamaura Y, Ae R, Takumi I, Sanjo N, Kitamoto T, Yamada M, Mizusawa H.
- Journal Title
  
  Journal of Epidemiology
  
  Volume: 25(1) Issue: 1 Pages: 8-14
- DOI
  10.2188/jea.je20140022
  10.2188/jea.JE20140022
- NAID
  130004694366
- ISSN
  0917-5040, 1349-9092
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26670435
[Journal Article] The influence of PRNP polymorphisms on human prion disease susceptibility: an update.2015
- Author(s)
  Kobayashi A, Teruya K, Matsuura Y, Shirai T, Nakamura Y, Yamada M, Mizusawa H, Mohri S, Kitamoto T.
- Journal Title
  
  Acta Neuropathol.
  
  Volume: 130 Pages: 159-170
- DOI
  10.1007/s00401-015-1447-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K01804, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-25280109
[Journal Article] Creutzfeldt-Jakob disease with homozygous M232R mutation: A case report.2015
- Author(s)
  Kon T, Miki Y, Arai A, Funamizu Y, Ueno T, Haga R, Nishijima H, Suzuki C, Nunomura J, Baba M, Oyama Y, Shiga Y, Kitamoto T, Tomiyama M.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 352 Pages: 108-9
- DOI
  10.1016/j.jns.2015.03.017
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Evaluating prion models on comprehensive mutation data of mouse PrP.2014
- Author(s)
  Shirai T, Saito M, Kobayashi A, Asano M, Hizume M, Ikeda S, Teruya K, Morita M, Kitamoto T.
- Journal Title
  
  Structure
  
  Volume: 22 Pages: 560-571
- DOI
  10.1016/j.str.2013.12.019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23550195, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-25280109, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26670435
[Journal Article] Molecular barriers to zoonotic transmission of prions.2014
- Author(s)
  Barria MA, Balachandran A, Morita M, Kitamoto T, Barron R, Manson J, Knight R, Ironside JW, Head MW.
- Journal Title
  
  Emerg Infect Dis.
  
  Volume: Jan;20(1) Pages: 88-97
- DOI
  10.3201/eid2001.130858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Extensive cortical spongiform changes with cerebellar small amyloid plaques: the clinicopathological case of MV2K+C subtype in Creutzfeldt-Jakob disease.2014
- Author(s)
  Araki K, Nakano Y, Kobayashi A, Matsudaira T, Sugiura A, Takao M, Kitamoto T, Murayama S, Obi T
- Journal Title
  
  Neuropathology.
  
  Volume: 34(6) Pages: 541-546
- DOI
  10.1111/neup.12133
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26430060, KAKENHI-PROJECT-26670435
[Journal Article] Relation between clinical findings and progression of cerebral cortical pathology in MM1-type sporadic Creutzfeldt-Jakob disease: Proposed staging of cerebral cortical pathology.2014
- Author(s)
  Iwasaki Y, Tatsumi S, Mimuro M, Kitamoto T, Hashizume Y, Yoshida M
- Journal Title
  
  J Neurol Sci.
  
  Volume: 341(1-2) Pages: 97-104
- DOI
  10.1016/j.jns.2014.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Panencephalopathic-type sporadic Creutzfeldt-Jakob disease with circumscribed spongy foci2014
- Author(s)
  Iwasaki Y, Tatsumi S, Mimuro M, Mori K, Ito M, Kitamoto T, Yoshida M.
- Journal Title
  
  Clin Neuropathol
  
  Volume: Mar-Apr;33(2) Pages: 160-4
- DOI
  10.5414/np300684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Distinct origins of dura mater graft-associated Creutzfeldt-Jakob disease: past and future problems.2014
- Author(s)
  Kobayashi A, Matsuura Y, Mohri S, Kitamoto T.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 2 Pages: 32-32
- DOI
  10.1186/2051-5960-2-32
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26670435
[Journal Article] Gerstmann-Straeussler-Scheinker disease with P102L prion protein gene mutation presenting with rapidly progressive clinical course.2014
- Author(s)
  Iwasaki Y, Mori K, Ito M, Nokura K, Tatsumi S, Mimuro M, Kitamoto T, Yoshida M.
- Journal Title
  
  Clin Neuropathol
  
  Volume: 33(5) Pages: 344-53
- DOI
  10.5414/np300733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26670435
[Journal Article] Clinical features of genetic Creutzfeldt-Jakob disease with V180I mutation in the prion protein gene.2014
- Author(s)
  Qina, T., N. Sanjo, M. Hizume, M. Higuma, M. Tomita, R. Atarashi, K. Satoh, I. Nozaki, T. Hamaguchi, Y. Nakamura, A. Kobayashi, T. Kitamoto, S. Murayama, H. Murai, M. Yamada and H. Mizusawa
- Journal Title
  
  BMJ Open.
  
  Volume: 4
- DOI
  10.1136/bmjopen-2014-004968
- NAID
  120005451799
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24591268, KAKENHI-PROJECT-25257506, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26670435
[Journal Article] Comparison of the clinical course of Japanese MM1-type sporadic Creutzfeldt-Jakob disease between subacute spongiform encephalopathy and panencephalopathic-type.2014
- Author(s)
  Iwasaki Y, Tatsumi S, Mimuro M, Kitamoto T, Yoshida M.
- Journal Title
  
  Clin Neurol Neurosurg.
  
  Volume: 121 Pages: 59-63
- DOI
  10.1016/j.clineuro.2014.03.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Creutzfeldt-Jakob disease with a codon 210 mutation: first pathological observation in a Japanese patient.2014
- Author(s)
  Tajima Y, Satoh C, Mito Y, Kitamoto T
- Journal Title
  
  Intern Med
  
  Volume: 53 Pages: 483-7
- NAID
  130003392674
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117005
[Journal Article] Creutzfeldt-Jakob Disease with a Codon 210 Mutation: First Pathological Observation in a Japanese Patient2014
- Author(s)
  Tajima Y, Satoh C, Mito Y, Kitamoto T.
- Journal Title
  
  Internal Medicine
  
  Volume: 53(5) Issue: 5 Pages: 483-487
- DOI
  10.2169/internalmedicine.53.0916
- NAID
  130003392674
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Critical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion protein2013
- Author(s)
  Taguchi Y, Mistica AM, Kitamoto T, Schatzl HM
- Journal Title
  
  PLoS Pathog
  
  Volume: 9(6)
- DOI
  10.1371/journal.ppat.1003466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Glycoform-selective prion formation in sporadic and familial forms of prion disease2013
- Author(s)
  Xiao X, Yuan J, Haik S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Insight into the frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease in Japan2013
- Author(s)
  Hamaguchi T, Sakai K,Noguchi-Shinohara M, Nozaki I, Takumi I, Sanjo N, Sadakane A, Nakamura Y, Kitamoto T, Saito N, Mizusawa H, Yamada M
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] An autopsied case of Creutzfeldt-Jakob disease with mutation in the prion protein gene codon 232 and type 1+2prion protein2013
- Author(s)
  Iwasaki Y, Yokoi F, Tatsumi S, Mimuro M, Iwai K, Kitamoto T, Yoshida M.
- Journal Title
  
  Neuropathology
  
  Volume: Jan 16;33(5) Pages: 568-75
- DOI
  10.1111/neup.12013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-22249034
[Journal Article] Glycoform-selective prion formation in sporadic and familial forms of prion disease2013
- Author(s)
  Xiao X, Yuan J, Haïk S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M/V and type 2 abnormal prion protein2013
- Author(s)
  Kobayashi A, Iwasaki Y, Otsuka H, Yamada M, Yoshida M, Matsuura Y, Mohri S, Kitamoto T.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: Nov 13;1(1) Pages: 74-74
- DOI
  10.1186/2051-5960-1-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Quantitative analysis of wet-heat inactivation in bovine spongiform encephalopathy2013
- Author(s)
  Matsuura Y, Ishikawa Y, Bo X, Murayama Y, Yokoyama T, Somerville RA, Kitamoto T, Mohri S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 432(1) Pages: 86-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Insight into the frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease in Japan2013
- Author(s)
  Hamaguchi T, Sakai K, Noguchi-Shinohara M, Nozaki I, Takumi I, Sanjo N, Sadakane A, Nakamura Y, Kitamoto T, Saito N, Mizusawa H, Yamada M
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 84(10) Pages: 1171-5
- DOI
  10.1136/jnnp-2012-304850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Graft-related disease progression in dura mater graft-associated Creutzfeldt-Jakob disease: a cross-sectional study2013
- Author(s)
  Sakai K, Hamaguchi T, Noguchi-Shinohara M, Nozaki I, Takumi I, Sanjo N, Nakamura Y, Kitamoto T, Saito N, Mizusawa H, Yamada M.
- Journal Title
  
  BMJ Open
  
  Volume: Aug 23;3(8)
- DOI
  10.1136/bmjopen-2013-003400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Glycoform-selective prion formation in sporadic and familial forms of prion disease2013
- Author(s)
  Xiao X, Yuan J, Haïk S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ
- Journal Title
  
  PLoS One
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185
[Journal Article] Characterization of variant Creutzfeldt-Jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes2013
- Author(s)
  Takeuchi A, Kobayashi A, Ironside JW, Mohri S, Kitamoto T
- Journal Title
  
  J Biol Chem
  
  Volume: 288(30) Pages: 21659-66
- DOI
  10.1074/jbc.m113.470328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Relationships between Clinicopathological Features and Cerebrospinal Fluid Biomarkers in Japanese Patients with Genetic Prion Diseases2013
- Author(s)
  Higuma M, Sanjo N, Satoh K, Shiga Y, Sakai K, Nozaki I, Hamaguchi T, Nakamura Y, Kitamoto T, Shirabe S, Murayama S, Yamada M, Tateishi J, Mizusawa H
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- DOI
  10.1371/journal.pone.0060003
- NAID
  120005231333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Relationships between Clinicopathological Features and Cerebrospinal Fluid Biomarkers in Japanese Patients with Genetic Prion Diseases2013
- Author(s)
  Higuma M, Sanjo N, Satoh K, Shiga Y, Sakai K, Nozaki I, Hamaguchi T, Nakamura Y, Kitamoto T, Shirabe S, Murayama S, Yamada M, Tateishi J, Mizusawa H
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- NAID
  120005231333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Glycoform-selective prion formation in sporadic and familial forms of prion disease2013
- Author(s)
  Xiao X, Yuan J, Haik S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ.
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- DOI
  10.1371/journal.pone.0058786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Quantitative analysis of wet-heat inactivation in bovine spongiform encephalopathy2013
- Author(s)
  Matsuura Y, Ishikawa Y, Bo X, Murayama Y, Yokoyama T, Somerville RA, Kitamoto T, Mohri S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: Mar 1;432(1)(Epub 2013 Jan 30) Pages: 86-91
- DOI
  10.1016/j.bbrc.2013.01.081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Enhanced antigen retrieval of amyloid β immunohistochemistry: re-evaluation of amyloid β pathology in Alzheimer disease and its mouse model2012
- Author(s)
  Kai H, Shin RW, Ogino K, Hatsuta H, Murayama S, Kitamoto T
- Journal Title
  
  J Histochem Cytochem
  
  Volume: 60 Pages: 761-769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185
[Journal Article] Enhanced antigen retrieval of amyloid β immunohistochemistry: re-evaluation of amyloid β pathology in Alzheimer disease and its mouse model2012
- Author(s)
  Kai H, Shin RW, Ogino K, Hatsuta H, Murayama S, Kitamoto T
- Journal Title
  
  J Histochem Cytochem
  
  Volume: 60 Pages: 761-769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Creutzfeldt-Jakob disease with the M232R mutation in the prion protein gene in two cases showing different disease courses: A clinicopathological study2012
- Author(s)
  Takeda N, Yokota O, Terada S, Haraguchi T, Nobukuni K, Mizuki R, Honda H, Yoshida H, Kishimoto Y, Oshima E, Ishizu H, Katsuya Satoh K, Kitamoto T, Ihara Y, Uchitomi Y.
- Journal Title
  
  J Neurol Sci
  
  Volume: 312 Pages: 108-108
- DOI
  10.1016/j.jns.2011.08.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591708, KAKENHI-PROJECT-24591714, KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-22249034
[Journal Article] Creutzfeldt-Jakob disease with the M232R mutation in the prion protein gene in two cases showing different disease courses: A clinicopathological study2012
- Author(s)
  Takeda N, Yokota O, Terada S, Haraguchi T, Nobukuni K, Mizuki R, Honda H, Yoshida H, Kishimoto Y, Oshima E, Ishizu H, Satoh K, Kitamoto T, Ihara Y, Uchitomi Y
- Journal Title
  
  J Neurol Sci
  
  Volume: 312 Pages: 108-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185
[Journal Article] Survival to akinetic mutism state in Japanese cases of MM1-type sporadic Creutzfeldt-Jakob disease is similar to Caucasians2011
- Author(s)
  Iwasaki Y, Mimuro M, Yoshida M, Kitamoto T, Hashizume Y
- Journal Title
  
  Eur J Neurol
  
  Volume: 18 Pages: 999-1002
- DOI
  10.1111/j.1468-1331.2010.03185.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] An autopsy case of MM2-cortical+thalamic-type sporadic Creutzfeldt-Jakob disease2011
- Author(s)
  Saito, Y, et al
- Journal Title
  
  Neuropathology
  
  Volume: 31 Pages: 523-530
- DOI
  10.1111/j.1440-1789.2010.01181.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500339, KAKENHI-PROJECT-22249034
[Journal Article] Serial diffusion-weighted MRI and SPECT findings in a Creutzfeldt-Jakob disease patient with V180I mutation2011
- Author(s)
  Kono S, Manabe Y, Fujii D, Sakai Y, Narai H, Omori N, Kitamoto T, Abe K
- Journal Title
  
  J Neurol Sci
  
  Volume: 301 Pages: 100-103
- DOI
  10.1016/j.jns.2010.10.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Deduction of the evaluation limit and termination timing ofmulti-round protein misfolding cyclic amplification from a titration curve2011
- Author(s)
  Takeuchi A, Komiya M, Kitamoto T, Morita M
- Journal Title
  
  Microbiol Immunol
  
  Volume: 55(7) Pages: 502-509
- DOI
  10.1111/j.1348-0421.2011.00340.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] An autopsied case of V180I Creutzfeldt-Jakob disease presenting with panencephalopathic-type pathology and a characteristic prion protein type2011
- Author(s)
  Iwasaki Y, Mori K, Ito M, Nagaoka M, Ieda T, Kitamoto T, Yoshida M, Hashizume Y
- Journal Title
  
  Neuropathology
  
  Volume: 31 Pages: 540-548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion2011
- Author(s)
  Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N
- Journal Title
  
  Nat Med
  
  Volume: 17 Pages: 175-178
- DOI
  10.1038/nm.2294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Heparin enhances the cell-protein misfolding cyclic amplification efficiency of variant Creutzfeldt-Jakob disease2011
- Author(s)
  Yokoyama T, Takeuchi A, Yamamoto M, Kitamoto T, Ironside JW, Morita M
- Journal Title
  
  Neurosci Lett
  
  Volume: 498 Pages: 119-123
- DOI
  10.1016/j.neulet.2011.04.072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Deduction of the evaluation limit and termination timing of multi-round protein misfolding cyclic amplification from a titration curve2011
- Author(s)
  Takeuchi A, Komiya M, Kitamoto T, Morita M
- Journal Title
  
  Microbiol Immunol
  
  Volume: 55(7) Pages: 502-9
- NAID
  10031121496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Co-occurrence of types 1 and 2 PrPres in sporadic Creutzfeldt-Jakob disease MM12011
- Author(s)
  Kobayashi A, Mizukoshi K, Iwasaki Y, Miyata H, Yoshida Y, Kitamoto T
- Journal Title
  
  Am J Pathol
  
  Volume: 178 Pages: 1309-1315
- DOI
  10.1016/j.ajpath.2010.11.069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Slow-progressive ataxia with amethionine-to-arginine point mutation in codon 232 in the prion protein gene (PRNP)2011
- Author(s)
  Yoshinori Nishimoto, Daisuke Ito, Shigeaki Suzuki, Toshihiko Shimizu, Tetsuyuki Kitamoto and Norihiro Suzuki.
- Journal Title
  
  Clin Neurol Neurosurg
  
  Volume: 113 Pages: 696-698
- DOI
  10.1016/j.clineuro.2011.04.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791002, KAKENHI-PROJECT-22249034
[Journal Article] A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells2010
- Author(s)
  Shimizu Y, Kaku-Ushiki Y, Iwamaru Y, Muramoto T, Kitamoto T, Yokoyama T, Mohri S, Tagawa Y
- Journal Title
  
  Microbiol Immunol
  
  Volume: 54 Pages: 112-121
- DOI
  10.1111/j.1348-0421.2009.00190.x
- NAID
  10029544087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Discordant clinicopathologic phenotypes in a Japanese kindred of fatal familial insomnia2010
- Author(s)
  Saitoh Y, Ogawa M, Naito Y, Komatsuzaki Y, Tagaya H, Arima K, Tamaoka A, Kitamoto T, Murata M
- Journal Title
  
  Neurology
  
  Volume: 74 Pages: 86-89
- DOI
  10.1212/wnl.0b013e3181c7da09
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Prospective 10-year surveillance of human prion diseases in Japan2010
- Author(s)
  Nozaki I, Hamaguchi T, Sakai K, Noguchi-Shinohara M, Nakamura Y, Sato T, Kitamoto T, Mizusawa H, Sanjo N, Morikawa F, Shiga Y, Kuroiwa Y, Nishizawa M, Kuzuhara S, Inuzuka T, Takeda M, Kuroda S, Abe K, Murai H, Murayama S, Tateishi J, Takumi I, Sirabe S, Harada M
- Journal Title
  
  Brain
  
  Volume: 133 Pages: 3043-3057
- DOI
  10.1093/brain/awq216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591117, KAKENHI-PROJECT-22249034
[Journal Article] Amino acid conditions near the GPI anchor attachment site of prion protein for the conversion and the GPI anchoring2010
- Author(s)
  Hizume M, Kobayashi A, Mizusawa H, Kitamoto T
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 391(4) Pages: 1681-1686
- DOI
  10.1016/j.bbrc.2009.12.128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Experimental verification of a traceback phenomenon in prion infection2010
- Author(s)
  Kobayashi A, Sakuma N, Matsuura Y, Mohri S, Aguzzi A, Kitamoto T
- Journal Title
  
  J.Virol
  
  Volume: 84(7) Pages: 3230-3238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Less protease-resistant PrP in a patient with sporadic CJD treated with intraventricular pentosan polysulphate2010
- Author(s)
  Terada T, Tsuboi Y, Obi T, Doh-Ura K, Murayama S, Kitamoto T, Yamada T, Mizoguchi K
- Journal Title
  
  Acta Neurol Scand
  
  Volume: 121 Pages: 127-130
- DOI
  10.1111/j.1600-0404.2009.01272.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Experimental verification of a traceback phenomenon in prion infection2010
- Author(s)
  Kobayashi A, Sakuma N, Matsuura Y, Mohri S, Aguzzi A, Kitamoto T
- Journal Title
  
  J. Virol
  
  Volume: 84 Pages: 3230-3238
- DOI
  10.1128/jvi.02387-09
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Age-dependent increase inlysosome-associated membrane protein1 and early-onset behavioral deficits in APPSL transgenic mouse model of Alzheimer's disease2010
- Author(s)
  Hashimoto T, Ogino K, Shin RW, Kitamoto T, Kikuchi T, Shimizu N
- Journal Title
  
  Neurosci Lett
  
  Volume: 469 Pages: 273-277
- DOI
  10.1016/j.neulet.2009.12.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Yamada M Medical procedures and risk for sporadic Creutzfeldt-Jakob disease, Japan, 1999-20082009
- Author(s)
  Hamaguchi T, Noguchi-Shinohara M, Nozaki I, Nakamura Y, Sato T, Kitamoto T, Mizusawa H
- Journal Title
  
  Emerg Infect Dis. 15
  
  Pages: 265-271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Human PrP219K is converted to PrPSc but shows heterozygous inhibition in vCJD infection2009
- Author(s)
  Hizume M, Kobayashi A, Teruya K, Ohashi H, Ironside JW, Mohri S, Kitamoto T
- Journal Title
  
  J Biol Chem 284
  
  Pages: 3603-3609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Medical procedures and risk for sporadic Creutzfeldt-Jakob disease, Japan, 1999-20082009
- Author(s)
  Hamaguchi T, Noguchi-Shinohara M, Nozaki I, Nakamura Y, Sato T, Kitamoto T, Mizusawa H, Yamada M
- Journal Title
  
  Emerg Infect Dis 15
  
  Pages: 265-71
- NAID
  120002104596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Heterozygous inhibition in prion infection The stone fence model2009
- Author(s)
  Kobayashi A, Hizume M, Teruya K, Mohri S, Kitamoto T
- Journal Title
  
  Prion 3
  
  Pages: 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] The number of octapeptide repeat affects the expression and conversion of prion protein2009
- Author(s)
  Hiraga C, Kobayashi A, Kitamoto T.
- Journal Title
  
  Biochem Biophys Res Commun (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology : An autopsy case showing typical clinical features of Creutzfeldt-Jakob disease2009
- Author(s)
  Haraguchi T, Terada S, Ishizu H, Sakai K, Tanabe Y, Nagai T, Takata H, Nobukuni K, Ihara Y, Kitamoto T, Kuroda S.
- Journal Title
  
  Neuropathology (in press)
- NAID
  10028191795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Heterozygous inhibition in prion infection-The stone fence model2009
- Author(s)
  Kobayashi A, Hizume M, Teruya K, Mohri S, Kitamoto T
- Journal Title
  
  Prion 3
  
  Pages: 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] The number of octapeptide repeat affects the expression and conversion of prion protein2009
- Author(s)
  Hiraga C, Kobayashi A, Kitamoto T
- Journal Title
  
  Biochem Biophys Res Commun (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] MM1-type sporadic Creutzfeldt-Jakob disease with unusually prolonged disease duration presenting with panencephalopathic-type pathology2008
- Author(s)
  Hoshino A, Iwasaki Y, Izumi M, Kimura S, Ibi T, Kitamoto T, Yoshida M, Hashizume Y, Sahashi K
- Journal Title
  
  Neuropathology 28(3)
  
  Pages: 326-332
- NAID
  10029319665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Plaque-type deposition of prion protein in the damaged white matter of sporadic Creutzfeldt-Jakob disease MM1 patients2008
- Author(s)
  Kobayashi A, Arima K, Ogawa M, Murata M, Fukuda T, Kitamoto T
- Journal Title
  
  Acta Neuropathol 116(5)
  
  Pages: 561-566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Human PrP 219K is converted to PrPsc but shows heterozygous inhibition in vCJD infection2008
- Author(s)
  Hizume M, Kobayashi A, Teruya K, Ohashi H, Ironside J W, Mohri S, and Kitamoto T.
- Journal Title
  
  J. Biol. Chem 284
  
  Pages: 3603-3609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] MM2-cortical-type sporadic Creutzfeldt-Jakob disease with early stage cerebral cortical pathology presenting with a rapidly progressive clinical course2008
- Author(s)
  Niimi Y, Iwasaki Y, Umemura T, Tanaka F, Yoshida M, Hashizume Y, Kitamoto T, Hirayama M, Sobue G.
- Journal Title
  
  Neuropathology 28(6)
  
  Pages: 645-651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] MM2-cortical-type sporadic Creutzfeldt-Jakob disease with early stage cerebral cortical pathology presenting with a rapidly progressive clinical course2008
- Author(s)
  Niimi Y, Iwasaki Y, Umemura T, Tranaka F, Yoshida M, Hashizume Y, Kitamoto T, Hirayama M, Sobue G
- Journal Title
  
  Neuropathology 28(6)
  
  Pages: 645-651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Thr but Asn of the N-glycosylation sites of PrP is indispensable for its misfolding2008
- Author(s)
  Ikeda s, kobayashi A, Kitamoto T
- Journal Title
  
  Biochem Biophys Res Commun 369(4)
  
  Pages: 1195-1198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Clinicopathologic characteristics of five autopsied cases of duramater-associated Creutzfeldt-Jakob disease2008
- Author(s)
  Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Kitamoto T, Sobue G.
- Journal Title
  
  Neuropathology 28(1)
  
  Pages: 51-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] MM1-type sporadic Creutzfeldt-Jakob disease with unusually prolonged disease duration presenting with panencephalopathic-type pathology2008
- Author(s)
  Hoshino A, Iwasaki Y, Izumi M, Kimura S, Ibi T, Kitamoto T, Yoshida M, Hashizume Y, Sahashi K.
- Journal Title
  
  Neuropathology 28(3)
  
  Pages: 326-332
- NAID
  10029319665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Plaque-type deposition of prion protein in the damaged white matter of sporadic Creutzfeldt-Jakob disease MM1 patients2008
- Author(s)
  Kobayashi A, Arima K, Ogawa M, Murata M, Fukuda T, Kitamoto T.
- Journal Title
  
  Acta Neuropathol 116(5)
  
  Pages: 561-566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Thr but Asn of the N-glycosylation sites of PrP is dispensable for its misfolding2008
- Author(s)
  Ikeda S, Kobayashi A, Kitamoto T
- Journal Title
  
  Biochem Biophys Res Commun 369
  
  Pages: 1195-1198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Clinicopathologic characteristics of five autopsied cases of dura mater-associated Creutzfeldt-Jakob disease2008
- Author(s)
  Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Kitamoto T, Sobue G
- Journal Title
  
  Neuropathology 28(1)
  
  Pages: 51-61
- NAID
  10025824159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Thr but Asn of the N-glycosylation sites of PrP is indispensable for its misfolding2008
- Author(s)
  Ikeda S, Kobayashi A, Kitamoto T.
- Journal Title
  
  Biochem Biophys Res Commun 364(9)
  
  Pages: 1195-1198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution.2007
- Author(s)
  Shiga Y, Satoh K, Kitamoto T, Kanno S, Nakashima I, Sato S, Fujihara K, Takata H, Nobukuni K, Kuroda S, Takano H, Umeda Y, Konno H, Nagasato K, Satoh A, Matsuda Y, Hidaka M, Takahashi H, Sano Y, Kim K, Konishi T, Doh-Ura K, Sato T, Sasaki K, Nakamura Y, Yamada M,Mizusawa H,Itoyama Y.
- Journal Title
  
  J Neurol. 254
  
  Pages: 1509-1517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Amyloid precursor protein cytoplasmic domain with phospho- Th668 accumulates in Alzheimer's disease and its transgenic models: a role tomediate interaction of A beta and tau.2007
- Author(s)
  Shin RW, Ogino K, Shimabuku A, Taki T, Nakashima H, Ishihara T, Kitamoto T.
- Journal Title
  
  Acta Neuropathol 113
  
  Pages: 627-636
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain2007
- Author(s)
  Kobayashi A, Asano M, Mohri S, Kitamoto T
- Journal Title
  
  J Biol Chem 282
  
  Pages: 30022-30028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Clinical features and diagnosis of dura mater graft associated Creutz feldt Jakob disease2007
- Author(s)
  Noguchi-Shinohara M, Hamaguchi T, Kitamoto T, Sato T, Nakamura Y, Mizusawa H, Yamada M.
- Journal Title
  
  Neurology 69
  
  Pages: 360-367
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Ophthalmic surgery in prion diseases.2007
- Author(s)
  Hamaguchi T, oguchi-Shinohara M, Nakamura Y, Sato T, Kitamoto T, Mizusawa H, Yamada M.
- Journal Title
  
  Emerg Infect Dis 13
  
  Pages: 162-164
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Enhanced Aquaporin-4 immunoreactivity in sporadic Creutzfeldt-Jakob disease.2007
- Author(s)
  Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Ito M, Kitamoto T, Wakayama Y, Sobue G.
- Journal Title
  
  Neuropathology. 27
  
  Pages: 314-323
- NAID
  10021235965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Amyloid precursor protein cytoplasmic domainwithphospho-Thr668accumulates inAlzheimer's disease and its transgenic models : a role tomediate interaction of Abeta and tau2007
- Author(s)
  Shin RW, Ogino K, Shimabuku A, Taki T, Nakashima H, Ishihara T, KitamotoT
- Journal Title
  
  Acta Neuropathol(Berl) 113(6)
  
  Pages: 627-636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain.2007
- Author(s)
  Kobayashi A, Asano M, Mohri S, Kitamoto T.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 30022-30028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Ophthalmic surgery in prion diseases2007
- Author(s)
  Hamaguchi T, Noguchi-Shinohara M, Nakamura Y, Sato T, KitamotoT,Mizusawa H, Yamada M
- Journal Title
  
  Emerg Infect Dis 13(1)
  
  Pages: 162-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Thr but Asn of the N-glycosylation sites of PrP is indispensable for its misfolding.2007
- Author(s)
  Ikeda S Kobayashi A, Kitamoto T
- Journal Title
  
  Biochem Biophys Res Commun 369
  
  Pages: 1195-1198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Enhanced Aquaporin-4 immunoreactivity in sporadic Creutzfeldt-Jakob disease2007
- Author(s)
  Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Ito M, Kitamoto T, Wakayama Y, Sobue G
- Journal Title
  
  Neuropathology 27
  
  Pages: 314-323
- NAID
  10021235965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Clinical features and diagnosis of dura mater graft associatedCreutzfeldt Jakob disease2007
- Author(s)
  Noguchi-Shinohara M, Hamaguchi T, Kitamoto T, Sato T, Nakamura Y,Mizusawa H, Yamada M
- Journal Title
  
  Neurology 69(4)
  
  Pages: 360-367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution2007
- Author(s)
  Shiga Y, Satoh K, Kitamoto T, Kanno S, Nakashima I, Sato S, Fujihara K, Takata H, Nobukuni K, Kuroda S, Takano H, Umeda Y, Konno H, Nagasato K, Satoh A, Matsuda Y, Hidaka M, Takahashi H, Sano Y, Kim K, Konishi T, Doh-ura K, Sato T, Sasaki K, Nakamura Y, Yamada M, Mizusawa H, Itoyama Y
- Journal Title
  
  J Neurol 254(11)
  
  Pages: 1509-1517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Severe cortical involvement in MV2 Creutzfeldt-Jakob disease : an autopsy case report2006
- Author(s)
  Ishihara K, Sugie M, Shiota J, Kawamura M, Kitamoto T, Nakano I
- Journal Title
  
  Neuropathology 26(5)
  
  Pages: 433-437
- NAID
  10019264032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Autopsy case of Creutzfeldt-Jakob disease with Met/Val heterozygosity at codon 129 and type 1 protease-resistant prion protein presenting some florid-type plaques and many Kuru plaques in the cerebellum2006
- Author(s)
  Kawauchi Y, Kamitani T, Yagishita S, Kitamoto T, Kishida H
- Journal Title
  
  Neuropathology 26(4)
  
  Pages: 313-317
- NAID
  10018059032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Autopsy case of sporadic Creutzfeldt-Jakob disease presenting with signs suggestive of brainstem and spinal cord involvement2006
- Author(s)
  Iwasaki Y, Iijima M, Kimura S, Yoshida M, Hashizume Y, Yamada M, Kitamoto T, sobue G
- Journal Title
  
  Neuropathology 26(6)
  
  Pages: 550-556
- NAID
  10019264481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Clinicopathologic characteristics of sporadic Japanese Creutzfeldt-Jakob disease classified according to prion protein gene polymorphism and prion protein type2006
- Author(s)
  Iwasaki Y, Yoshida M, Hashizume Y, Kitamoto T, Sobue
- Journal Title
  
  Acta Neuropathol(Berl) 112(5)
  
  Pages: 561-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] The MM2-cortical form of sporadic Creutzfeldt-Jakob disease presenting with visual disturbance2006
- Author(s)
  Nozaki I, Hamaguchi T, Noguchi-Shimohara M, Ono k, Shirasaki H, Komai K, Kitamoto T, Yamada M
- Journal Title
  
  Neurology 67(3)
  
  Pages: 531-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] MM2-thalamic-type sporadic Creutzfeldt-Jakob disease with widespread neocortical pathology2006
- Author(s)
  Hirose K, Iwasaki Y, Izumi M, Yoshida M, Hashizume Y, Kitamoto T, Sahashi K
- Journal Title
  
  Acta Neuropathol(Berl) 112(4)
  
  Pages: 503-511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Analyses of Gerstmann-Straussler syndrome with 102Leu219Lys using monoclonal antibodies that specifically deted human prion protein with 219Glu.2000
- Author(s)
  Muramoto T, Tanaka T, Kitamoto N, et al.
- Journal Title
  
  Neuroscience Letters 288(3)
  
  Pages: 179-182
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-11680731
[Journal Article] Analyses of Gerstmann-Straussler syndrome with 102Leu219Lys using monoclonal antibodies that specifically detect human prion protein with 219Glu.2000
- Author(s)
  Muramoto T, Tanaka T, Kitamoto N, Sano C, Hayashi Y, Kutomi T, Yutani C, Kitamoto T
- Journal Title
  
  Neurosci Lett 288(3)
  
  Pages: 179-182
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-11680731
[Presentation] Diagnosis of MMiK type acquired Creutzfeldt-Jakob disease with cell- protein misfolding amplification (PMCA)2017
- Author(s)
  Takeuchi A, Kobayashi A, Morita M, Kitamoto T
- Organizer
  日本認知症学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09307
[Presentation] Identification of the origin of Creutzfeldt-Jakob disease after cadaver-sourced pituitary growth hormone treatment using an amplification property in protein misfolding cyclic amplificatiton2016
- Author(s)
  Takeuchi A, Yamamoto M, Parchi P, HaiK S, Morita M, Kobayashi A, Kitamoto T
- Organizer
  PRION2016
- Place of Presentation
  学術総合センター（東京）
- Year and Date
  2016-05-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09307
[Presentation] cell-PMCA of acquired Creutzfeldt-Jakob disease2015
- Author(s)
  Atsuko Takeuchi, Atsushi Kobayashi, Piero Parchi, Masahito Yamada, Masanori Morita, Shuusei Uno and Tetsuyuki Kitamoto
- Organizer
  Asia Pacific Society of Prion Research
- Place of Presentation
  金沢 (石川県立音楽堂)
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09307

1. TATEISHI Jun (70033305)

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Kitamoto Tetsuyuki 北本 哲之

KITAMOTO Tetsuyuki 北本 哲之

北本 哲之 キタモト テツユキ

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視床型クロイツフェルト・ヤコブ病の新しい分類法の樹立Principal InvestigatorOngoing

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FFI SFIに見られる新しいプリオンの同定と新分類の確立のための国際共同研究Principal InvestigatorOngoing

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各種プリオンによる末梢からの感染力評価法の樹立Principal InvestigatorOngoing

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Is thalamic CJD a sporadic form of fatal familial insomnia?Principal Investigator

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Study for highly sensitive PMCA amplification with vCJD prionsPrincipal Investigator

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new classification of sporadic CJD with MV2.Principal Investigator

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To establish a rapid diagnostic test in a vCJD patient with Codon 129 Val/ValPrincipal Investigator

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To study the molecular mechanism of prion protein conversionPrincipal Investigator

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Study of the pathomechanism in the prion infectionPrincipal Investigator

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Kitamoto Tetsuyuki 北本哲之

KITAMOTO Tetsuyuki 北本哲之

北本哲之キタモトテツユキ