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KAWAHARA Kazuyoshi  川原 一芳

… Alternative Names

KAWAHARA Yoshikazu  川原 一芳

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Researcher Number 20195126
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1215-5240
Affiliation (Current) 2025: 関東学院大学, 理工学部, 教授
Affiliation (based on the past Project Information) *help 2013 – 2014: 関東学院大学, 理工学部, 教授
2011 – 2012: 関東学院大学, 工学部, 教授
2004: Kanto Gakuin University, College of Engineering, Professor, 工学部, 教授
2003: 社団法人北里研究所, 基礎研究所, 室長
2002: 財団法人北里研究所, 基礎研究所, 室長 … More
2001: Kitazato Research Institute, Division of Bacteriology, Chief, 基礎研究所・細菌研究室, 室長
2001: 北里研究所, 基礎研究所細菌研究室, 室長
2000: 北里研究所, 基礎研究所細菌研究室, 室長(研究職)
1999: 北里研究所, 基礎研究所細菌研究室, 室長
1989: The Kitasato Institute, Dep. Bacteriol. 2nd Lab., Subchief of Laboratory, 細菌部第2室, 室長補佐
1989: 北里研究所、細菌部第2室, 室長補佐
1988: 北里研究所, 細菌部第2室, 研究員 Less
Review Section/Research Field
Principal Investigator
Bacteriology (including Mycology) / Bacteriology (including Mycology)
Except Principal Investigator
細菌学 / 応用薬理学・医療系薬学 / Environmental pharmacy
Keywords
Principal Investigator
Clonine / Acyl transferase / Pathogenicity / Growth temperature / Chemical structure / Lipid A / Endotoxin / Yersinia pestis / マクロファージ活性化 / コア糖鎖 … More / 発現調節 / 培養温度 / クローニング / 脂肪酸転移酵素 / 病原性 / 生育温度 / 化学構造 / リピドA / エンドトキシン / ペスト菌 / 乳酸菌 / ペプチドグリカン / 糖脂質 / 自然免疫 … More
Except Principal Investigator
Salmonella choleraesuis / Bacteremia / Virulence plasmid / Salmonella / 毒力プラスミド / 菌血症 / 毒カプラスミド / サルモネラ / neutrophil / renal damage / lipopoly saccharide / verotoxin / E-coli O157 / 時間薬理 / IL6 / 腎障害 / 抗好中球抗体 / O-157 / 好中球 / 臓器障害 / リポ多糖 / ベロ毒素 / 大腸菌O-157 / 除染 / サリン / 神経ガス / Sphingobium / 固定化酵素 / 有機リン分解酵素 / 神経剤 / 有機リン系化合物 Less
  • Research Projects

    (5 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (14 People)
  •  The role of glycolipids and peptidoglycan of lactic acid bacteria for the stimulation of innate immunityPrincipal Investigator

    • Principal Investigator
      KAWAHARA Kazuyoshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Kanto Gakuin University
  •  Investigation of decontamination of nerve agents using organophosphorus hydrolase

    • Principal Investigator
      OHMORI Takeshi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental pharmacy
    • Research Institution
      National Research Institute of Police Science
  •  Chemical structure of Yersinia pestis endotoxin and its role in the infectionPrincipal Investigator

    • Principal Investigator
      KAWAHARA Kazuyoshi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Kanto Gakuin University
      Kitasato Institute
  •  Study on Escherichia coli O-157-induced renal damage

    • Principal Investigator
      FUJIMURA Akio
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Jichi Medical University
  •  Correlation between infection mechanisms and virulence plasmid of Salmonella choleraesuis

    • Principal Investigator
      DANBARA Hirofumi
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      細菌学
    • Research Institution
      The Kitasato Institute

All 2014 2013 2012 2011 2004 2003 2002 Other

All Journal Article Presentation Book

  • [Book] エンドトキシン研究6 ペスト菌LPSの培養温度による構造変化とその病原性発現における意義(編集:日本エンドトキシン研究会、楠本正一、小玉正智、谷徹)2003

    • Author(s)
      川原一芳, 塚野尋子, 渡辺治雄, Buko Lindner, Otto Holst, 松浦基博
    • Publisher
      医学図書出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570255
  • [Journal Article] Improvement of organophosphorus hydrolase activity toward nerve agents by amino acid substitutions2014

    • Author(s)
      Kosuke Nakayama, Satoshi Ishikawa, Kazuyoshi Kawahara, Takeshi Ohmori, Yasuo Seto
    • Journal Title

      Forensic Toxicology

      Volume: 32 Issue: 2 Pages: 208-213

    • DOI

      10.1007/s11419-013-0223-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Journal Article] Improvement of organophosphorus hydrolase activity toward nerve agents by amino acid substitutions2014

    • Author(s)
      Nakayama K, Ishikawa S, Kawahara K, Ohmori T, Seto Y
    • Journal Title

      Forensic Toxicology

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-23590163
  • [Journal Article] CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells.2013

    • Author(s)
      Sanderson, J. P., Brennan, P. J., Mansour, S., Matulis, G., Patel, O., Lissin, N., Godgrey, D. I., Kawahara, K., Zahringer, U., Rossjohn, J., Brenner, M. B., and Gadola, S. D.
    • Journal Title

      Eur. J. Immunol.

      Volume: 43 Pages: 815-825

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590537
  • [Journal Article] Decontamination of nerve agents by immobilized organophosphorus hydrolase2013

    • Author(s)
      Ohmori T, Kawahara K, Nakayama K, Shioda A, Ishikawa S, Kanamori-Kataoka M, Kishi S, Komano A, Seto Y
    • Journal Title

      Forensic Toxicology

      Volume: 31 Pages: 37-43

    • Data Source
      KAKENHI-PROJECT-23590163
  • [Journal Article] Method for estimation of toxic endotoxin in inactivated Salmonella vaccine in D-galactosamine-sensitized mice2004

    • Author(s)
      N.Takikawa, K.Kawahara, A.Sawata, K.Kume
    • Journal Title

      The Journal of Veterinary Medical Science 66

      Pages: 1591-1593

    • NAID

      130000448694

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570255
  • [Journal Article] Method for estimation of toxic endotoxin in inactivated Salmonella vaccine in D-galactosamine-sensitized mice2004

    • Author(s)
      N.Takikawa, K.Kawahara, A.Sawata, K.Kume
    • Journal Title

      The Journal of Veterinary Medical Science 66(12)

      Pages: 1591-1593

    • NAID

      130000448694

    • Data Source
      KAKENHI-PROJECT-14570255
  • [Journal Article] Modification of the structure of Yersinia pestis LPS by growth temperature and its significance for the expression of the pathogenicity2003

    • Author(s)
      K.Kawahara, H.Tsukano, H.Watanabe, B.Lindner, O.Holst, M.Matsuura
    • Journal Title

      Endotoxin Research 6(Eds : S.Kusumoto, M.Kodama, T.Tani, Japan Endotoxin Society)(Igaku Tosho Shuppan Co.)

      Pages: 60-71

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570255
  • [Journal Article] Structure of the core-oligosaccharide with a characteristic D-glycero-α-D-talo-oct-2-ulosylonate-(2→4)-3-deoxy-D-manno-oct-2-ulosonate[α-Ko-(2→4)-Kdo] disaccharide in the lipopolysaccharide from Burkholderia cepacia2003

    • Author(s)
      Y.Isshiki, U.Zahringer, K.Kawahara
    • Journal Title

      Carbohydrate Research 338

      Pages: 2659-2666

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570255
  • [Journal Article] Structure of the core-oligosaccharide with a characteristic D-glycero-α-D-talo-oct-2-ulosylonate-(2→4)-3-deoxy-D-manno-oct-2-ulosonate [α-Ko-(2→4)-Kdo] disaccharide in the lipopolysaccharide from Burkholderia cepacia2003

    • Author(s)
      Y.Isshiki, U.Zahringer, K.Kawahara
    • Journal Title

      Carbohydrate Research 338

      Pages: 2659-2666

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570255
  • [Journal Article] Modification of the structure and activity of lipid A in Yersinia pestis lipopolysaccharide by growth temperature2002

    • Author(s)
      K.Kawahara, H.Tsukano, H.Watanabe, B.Lindner, M.Matsuura
    • Journal Title

      Infection and Immunity 70

      Pages: 4092-4098

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570255
  • [Presentation] 有機リン系神経剤を分解するOrganophosphorus hydrolase の固定化2014

    • Author(s)
      中山 公介、大森 毅、瀬戸 康雄、有路 沙織、石川 暁志、川原 一芳
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      川崎市 明治大学
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] Improvement of activity and immobilization of organophosphorus hydrolase for the decontamination of nerve agents2014

    • Author(s)
      Nakayama K , Ishikawa S, Ohmori T , Seto Y , Kawahara K
    • Organizer
      International Union of Microbiological Societies Congress
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] 有機リン系神経剤を分解するOrganophosphorus hydrolaseの固定化2014

    • Author(s)
      中山公介、大森毅、瀬戸康雄、有路沙織、石川暁志、川原一芳
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      川崎 (講演番号4DO2a10)
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] Organophosphorus hydrolaseによる神経剤分解2014

    • Author(s)
      大森毅、川原一芳、石川暁志、中山公介、瀬戸康雄
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      (発表番号28amL-039)
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] Improvement of activity and immobilization of organophosphorus hydrolase for the decontamination of nerve agents2014

    • Author(s)
      Kosuke Nakayama, Satoshi Ishikawa, Takeshi Ohmori, Yasuo Seto, Kazuyoshi Kawahara
    • Organizer
      International Union of Microbiological Societies Congress
    • Place of Presentation
      モントリオール カナダ
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] Organophosphorus hydrolaseによる神経剤分解2014

    • Author(s)
      大森 毅、川原 一芳、石川 暁志、中山 公介、瀬戸 康雄
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市 熊本市民体育館
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] 神経剤高分解能を有する変異Organophosphorus hydrolaseの性状と迅速精製法の検討2013

    • Author(s)
      中山公介、大森毅、瀬戸康雄、有路沙織、石川暁志、川原一芳
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台 (講演番号3C12p08)
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] Organophosphorus hydrolaseのアミノ酸置換による改良と精製法の検討2012

    • Author(s)
      中山公介、大森毅、瀬戸康雄、有路沙織、石川暁志、川原一芳
    • Organizer
      2012年度日本農芸化学会
    • Place of Presentation
      京都 (演題番号2C09p19)
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] Decomposition of nerve agents by organophosphorus hydrolase2012

    • Author(s)
      Ohmori T, Kawahara K, Ishikawa S, Nakayama K, Kanamori-Kataoka M, Seto Y
    • Organizer
      The Meeting of the International Association of Forensic Toxicologist 2012 #P-159, 50th annual meeting abstract p108
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] 変異導入したOrganophosphorus hydrolaseの神経剤分解活性(第二報)2012

    • Author(s)
      大森毅、川原一芳、石川暁志、中山公介、瀬戸康雄
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      (演題番号3P-304)
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] Organophosphorus hydrolaseのアミノ酸置換による改良と精製法の検討2012

    • Author(s)
      中山 公介、大森 毅、瀬戸 康雄、有路 沙織、石川 暁志、川原 一芳
    • Organizer
      2012年度日本農芸化学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] 変異導入したOrganophosphorous hydrolaseの神経剤分解活性2011

    • Author(s)
      大森 毅、川原 一芳、石川 暁志、中山 公介、金森 美江子、瀬戸 康雄
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] 変異導入したOrganophosphorus hydrolaseの神経剤分解活性2011

    • Author(s)
      大森毅、川原一芳、石川暁志、中山公介、金森美江子、瀬戸康雄
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都 (演題番号2p-0207)
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] Decomposition of nerve agents by organophosphorus hydrolase

    • Author(s)
      akeshi Ohmori, Kazuyoshi Kawahara, Satoshi Ishikawa, Kosuke Nakayama,Mieko Kataoka-Kanamori, and Yasuo Seto
    • Organizer
      50th annual meeting of the International Association of Forensic Toxicologist
    • Place of Presentation
      浜松
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] 神経剤高分解能を有する変異Organophosphorus hydrolaseの性状と迅速精製法の検討

    • Author(s)
      中山 公介、大森 毅、瀬戸 康雄、有路 沙織、石川 暁志、川原 一芳
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] 変異を導入したOrganophosphorous hydrolaseの神経剤分解活性(第二報)

    • Author(s)
      大森 毅、川原 一芳、石川 暁志、中山 公介、瀬戸 康雄
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23590163
  • [Presentation] Enterococcus faecium由来グリセロ糖脂質の化学的性状

    • Author(s)
      川原一芳
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      岐阜県岐阜市
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24590537
  • [Presentation] 乳酸菌由来リゾチーム可溶化ペプチドグリカンのサイトカイン産生活性

    • Author(s)
      尾之上さくら、川原一芳
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      岐阜県岐阜市
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24590537
  • 1.  OHMORI Takeshi (70356195)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 19 results
  • 2.  ONOUE Sakura (60214194)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  FUJIMURA Akio (90156901)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  TSURUOKA Shu-ich (50285798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  SUGIMOTO Koh-ichi (90244491)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MATSUURA Motohiro (20150089)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  DANBARA Hirofumi (40114558)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MATSUI Hidenori (30219373)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  MORIGUCHI Ryozo (30101299)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KINJO Yuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  MIZUGUCHI Yuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TAKADA Haruhiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TADA Hiroyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  IIDA Hirokazu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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