MAKITA Koshi 槇田浩史

… Alternative Names

Researcher Number	20199657
Other IDs
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Affiliation (based on the past Project Information) *help	2016 – 2019: 東京医科歯科大学, 大学院医歯学総合研究科, 教授 2013 – 2016: 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 2006 – 2007: 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 1999 – 2002: Tokyo Medical & Dental University, Professor, 大学院・医歯学総合研究科, 教授 1999: 東京医科歯科大学, 医学部, 教授 … More
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies / Anesthesiology Except Principal Investigator Anesthesiology/Resuscitation studies / Anesthesiology / 麻酔学 / Medical sociology / Emergency medicine / Medical and hospital managemen
Keywords	Principal Investigator 毒性評価 / iPS細胞 / セボフルラン / iPS細胞由来神経細胞 / 麻酔薬 / ケタミン / ミトコンドリア / アポトーシス / 神経幹細胞 / 麻酔薬毒性 … More Except Principal Investigator ARDS / Partial liquid ventilation / Liquid ventilation / 一酸化窒素 / 液体換気 / partial liquid ventilation / Perfluorocarbon / Perflubron / 肺動脈圧 / 肺毛細管静水圧 / アムリノン / 呼吸不全 / 肺毛細管圧 / 肺高血圧 / ケタンセリン / EDRF / Garr定数 / 肺動脈閉塞法 / 一酸化窒素(NO) / 敗血症性ショック / MRS / LPS / carboxy-PTIO / エンドトキシン / NO / nitiic oxid / Corboxy-PITO / gravity / stress / analgesia / rat / Stress induced analgesia / 鎮痛 / 重力ストレス / perflubron / perflubyon / 急性呼吸不全 / オレイン酸肺傷害 / Vasodilator / プロスタグランディンE1 / プロスタサイクリン / Perfluoro Carbon / Prostaglandin E_1 / Prostacyclin / エンドトキシン血症 / perfluorocarbon / Endotoxemia / 周術期医学 / 医療安全 / 医療情報 / データベース / PERIOPERATIVE MEDICINE / PATIENT SAFETY / MEDICAL INFORMATICS / DATA BASE / 細胞外トラップ / 周術期腎障害 / 臓器障害 / 急性腎障害 / 血液凝固 / 好中球 / cell free DNA / 麻酔科 / 医療の質 / 安全性 / 国際比較 / 燃え尽き / 医療・福祉 / 神経炎症 / 認知機能障害 / セボフルラン / 脳 / 脳・神経 / 麻酔 / 敗血症 / プロポフォール / ミトコンドリア / 毒性評価 / プロポフォール注入症候群 / 心筋細胞 / アポトーシス / オートファジー Less

ヒトiPS細胞由来神経細胞の分化成熟過程における全身麻酔薬の毒性とそのメカニズムPrincipal Investigator
- Principal Investigator
  
  槇田浩史
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Tokyo Medical and Dental University
International comparison of quality and safety in anesthesia and perioperative care
- Principal Investigator
  
  Oshima Tsutomu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical and hospital managemen
- Research Institution
  Tokyo Medical and Dental University
Pathophysiology of sepsis-related encephalopathy and investigation of therapeutic agents
- Principal Investigator
  
  SATOMOTO Maiko
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Toho University
  Nagoya University
Cytotoxicity of propofol in human induced pluripotent stem cell-derived cardiomyocytes and hepatocytes
- Principal Investigator
  
  Kido Koji
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Tokyo Medical and Dental University
Relationship between perioperative neutrophil extracellular trap formation and organ dysfunction
- Principal Investigator
  
  UCHIDA Tokujiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokyo Medical and Dental University
Neurotoxicity of anesthetics in the developing neurons: in vitro model to assess the neurotoxicity in human induced pluripotent stem cell derived neurons.Principal Investigator
- Principal Investigator
  
  MAKITA Koshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Anesthesiology
- Research Institution
  Tokyo Medical and Dental University
Designing and implementing a large-scale perioperative database and data analysis
- Principal Investigator
  
  SAWA Tomohiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical sociology
- Research Institution
  Teikyo University
重力ストレス環境下における痛みの変調とその機序
- Principal Investigator
  
  川内泰子
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical and Dental University
Partial liquid ventilation as an anti-inflammatory treatment in ARDS
- Principal Investigator
  
  NAKAZAWA Koichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical & Dental University
Pulmonary administration of vasodilators during partial liquid ventilation in ARDS.
- Principal Investigator
  
  KOICHI Nakazawa
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical & Dental University
各種吸入麻酔薬の虚血肝エネルギー代謝に及ぼす影響
- Principal Investigator
  
  豊岡秀訓
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Tsukuba
  Tokyo Medical and Dental University
Uptake and elimination of sevoflurane in rabbit tissues-An in vivo 19F magnetic resonance studyPrincipal Investigator
- Principal Investigator
  
  MAKITA Koshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical and Dental University
エンドトキシンショックにおける呼気中一酸化窒素濃度と重症度の関連についてPrincipal Investigator
- Principal Investigator
  
  槙田浩史, 槇田浩史
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical and Dental University
急性呼吸不全における肺毛細管静水圧とその操作に関する研究
- Principal Investigator
  
  豊岡秀訓
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  麻酔学
- Research Institution
  Tokyo Medical and Dental University

All 2019 2018 2017 2016 2015 2004 2001 2000 Other

All Journal Article Presentation

[Journal Article] Blood-brain Barrier Disruption Caused by Neonatal Sevoflurane-Induced Depends on Exposure Time and Is Reversible in Mice2019
- Author(s)
  Sun Z, Satomoto M, Adachi YU, Makita K.
- Journal Title
  
  Korean J Anesthesiol.
  
  Volume: 72 Pages: 389-391
- DOI
  10.4097/kja.d.19.00029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10928
[Journal Article] Cytotoxicity of propofol in human induced pluripotent stem cell-derived cardiomyocytes2018
- Author(s)
  Kido K, Ito H, Yamamoto Y, Makita K, Uchida T
- Journal Title
  
  Journal of Anesthesia
  
  Volume: 32 Pages: 120-131
- DOI
  10.1007/s00540-017-2441-0
- NAID
  40021468186
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10929, KAKENHI-PROJECT-16K20380
[Journal Article] Neonatal Sevoflurane Exposure Induces Adulthood Fear-induced Learning Disability and Decreases Glutamatergic Neurons in the Basolateral Amygdala.2018
- Author(s)
  Satomoto Maiko、Sun Zhongliang、Adachi Yushi U.、Makita Koshi
- Journal Title
  
  J Neurosurg Anesthesiol.
  
  Volume: 30 Pages: 59-64
- DOI
  10.1097/ana.0000000000000387
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10930, KAKENHI-PROJECT-16K10928
[Journal Article] Sevoflurane preconditioning ameliorates lipopolysaccharide-induced cognitive impairment in mice2018
- Author(s)
  里元麻衣子　孫忠良　足立裕史　木下浩之　槇田浩史
- Journal Title
  
  Experimental Animals
  
  Volume: Nov 29 Issue: 2 Pages: 193-200
- DOI
  10.1538/expanim.17-0102
- NAID
  130006733608
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10928, KAKENHI-PROJECT-16K10930
[Journal Article] Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction.2016
- Author(s)
  Qi Y, Uchida T, Yamamoto M, Yamamoto Y, Kido K, Ito H, Ohno N, Asahara M, Yamada Y, Yamaguchi O, Mitaka C, Tomita M, Makita K.
- Journal Title
  
  Anesthesiol Res Pract
  
  Volume: 2016 Pages: 2794364-2794364
- DOI
  10.1155/2016/2794364
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05004, KAKENHI-PROJECT-25462427
[Journal Article] Ketamine causes mitochondrial dysfunction in human induced pluripotent stem cell-derived neurons.2015
- Author(s)
  Ito H, Uchida T, Makita K.
- Journal Title
  
  PLOS ONE
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670666
[Journal Article] Ketamine causes mitochondrial dysfunction in human induced pluripotent stem cell-derived neurons.2015
- Author(s)
  Ito H, Uchida T, Makita K
- Journal Title
  
  PLoS One
  
  Volume: 10
- DOI
  10.1371/journal.pone.0128445
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05004, KAKENHI-PROJECT-25670759
[Journal Article] Interactions between rat alveolar epithelial cells and bone marrow-derived mesenchymal stem cells: an in vitro co-culture model.2015
- Author(s)
  Ito H, Uchida T, Makita K.
- Journal Title
  
  Intensive Care Med Exp.
  
  Volume: 3 Pages: 53-53
- DOI
  10.1186/s40635-015-0053-2
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05004, KAKENHI-PROJECT-25670759
[Journal Article] Nociceptive threshold can be changed by gravity stimulation in rats2004
- Author(s)
  Kawauchi Y, Zeredo JL, Takeuchi Y, Kimoto M, Kumei Y, Makita K, Toda K
- Journal Title
  
  Stress and Heaith 20
  
  Pages: 45-50
- Data Source
  KAKENHI-PROJECT-14770760
[Journal Article] Hypergravity and opioid-mediated pain suppression in rats.2001
- Author(s)
  Kumei Y, Shimokawa R, Terasawa M, Shimokawa H, Kawauchi Y, Makita
- Journal Title
  
  Journal of Gravity Physiology 8
  
  Pages: 111-112
- Data Source
  KAKENHI-PROJECT-14770760
[Journal Article] Hypergravity modulates ret hypothalamic response.2001
- Author(s)
  Kumei Y, Shimokawa R, Toda K, Kawauchi Y, Makita K, Shimokawa H.
- Journal Title
  
  Space Utilization Reserch 17
  
  Pages: 35-38
- Data Source
  KAKENHI-PROJECT-14770760
[Journal Article] Gravity stress modulates pain sensation of rat via hypothalamus.2001
- Author(s)
  Kumei Y, Shimokawa R, Kimoto R, Kawauchi Y, Shimokawa H, Makita K
- Journal Title
  
  Biology Science of Space 15
  
  Pages: 258-259
- NAID
  10007425378
- Data Source
  KAKENHI-PROJECT-14770760
[Journal Article] Nociceptive responses and immunohistochemical changes in the rat brain under gravity stress2000
- Author(s)
  Kumei Y, Toda K, Kawauchi Y, Shimokawa R, Shimokawa H, Makita K
- Journal Title
  
  Journal of Gravity Physiology 7
  
  Pages: 91-92
- Data Source
  KAKENHI-PROJECT-14770760
[Presentation] プロポフォール高用量・長時間曝露によるヒト人工多能性幹細胞由来心筋細胞での毒性評価：プロポフォール注入症候群の病態機序の解明にむけて2017
- Author(s)
  木戸浩司、内田篤治郎、山本雄大、槇田浩史
- Organizer
  日本麻酔科学会　第64回学術集会
- Data Source
  KAKENHI-PROJECT-16K10929
[Presentation] プロポフォール高用量・長時間曝露によるヒト人工多能性幹細胞由来心筋細胞での毒性評価：プロポフォール注入症候群の病態機序の解明にむけて2017
- Author(s)
  木戸浩司, 内田篤治郎, 山本雄大 , 槇田浩史
- Organizer
  日本麻酔科学会第64回学術集会
- Place of Presentation
  神戸国際会議場、兵庫県神戸市
- Year and Date
  2017-06-08
- Data Source
  KAKENHI-PROJECT-16K10929
[Presentation] セボフルランの前投与は、LPS投与後の全身性炎症反応による認知機能低下を減弱させる効果がある2017
- Author(s)
  里元麻衣子　孫忠良　足立裕史　木下浩之　槇田浩史
- Organizer
  日本麻酔科学会大64回学術集会
- Data Source
  KAKENHI-PROJECT-16K10928
[Presentation] セボフルランの前投与は、LPS投与後の全身性炎症反応による認知機能低下を減弱させる効果がある2017
- Author(s)
  里元麻衣子、孫忠良、張愛玲、足立裕史、槇田浩史
- Organizer
  日本麻酔科学会第64回学術集会
- Place of Presentation
  神戸ポートピアホテル(兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-16K10928
[Presentation] Ketamine Causes Mitochondrial Dysfunction in Human Induced Pluripotent Stem Cell-derived Neurons2015
- Author(s)
  Ito H, Uchida T, Makita K
- Organizer
  Anesthesiology 2015
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-10-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05004
[Presentation] Retrospective Analysis for Intra-Operative Ventilatory Management During General Anesthesia: Is Lung Protective Ventilation Accepted as a Common Practice in the Operating Room?2015
- Author(s)
  Itoh Y, Kasuga T, Toyama S, Uchida T, Makita K
- Organizer
  Anesthesiology 2015
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-10-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05004
[Presentation] Perioperative Elevation in Cell Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction: A Multicenter Observational Study.2015
- Author(s)
  5.Yamamoto Y, Uchida T, Ito H, Kido K, Yamamoto Y, Yamada Y, Ohno N, Asahara M, Yamaguchi O, Makita K.
- Organizer
  Anesthesiology 2015
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-10-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05004
[Presentation] ヒト人工多能性幹細胞由来神経細胞を用いたケタミンの毒性評価：ミトコンドリア機能障害およびアポトーシス誘導に関する検討
- Author(s)
  伊藤裕之、内田篤治郎、槇田浩史
- Organizer
  日本麻酔科学会　第62回学術集会
- Place of Presentation
  神戸
- Year and Date
  2015-05-28 – 2015-05-30
- Data Source
  KAKENHI-PROJECT-25670666

1. UCHIDA Tokujiro (40262183)

# of Collaborated Projects: 6 results

# of Collaborated Products: 11 results
2. YOKOYAMA Kuninori (00014176)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. KOICHI Nakazawa (10207756)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MATSUZAWA Yoshiyasu (90311654)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SATOMOTO Maiko (10611551)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. 豊岡秀訓 (80010362)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 天羽敬祐 (30045992)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. ITO Hiroyuki (80595554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. YAMADA Ichiro (90182518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SAWA Tomohiro (50349247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. IRITA Kazuo (80168541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TSUZAKI Koichi (90138107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MORITA Kiyoshi (40108171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKATUKA Hideki (70263580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAKEDA Junzo (30101968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Oshima Tsutomu (50223805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Kido Koji (60772621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. 宇田川友之 (80213429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 川内泰子 (00323717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 戸田一雄 (80134708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. 粂井康宏 (30161714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
22. 横山訓典 (80133841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 三高千恵子 (20126254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 佐藤元 (70272424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. ADACHI Yushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

MAKITA Koshi 槇田 浩史

槇田 浩史 マキタ ヒロシ

槙田 浩史 マキタ コウシ

まき田 浩史 マキタ コウシ

Research Projects

Research Products

Co-Researchers

ヒトiPS細胞由来神経細胞の分化成熟過程における全身麻酔薬の毒性とそのメカニズムPrincipal Investigator

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Neurotoxicity of anesthetics in the developing neurons: in vitro model to assess the neurotoxicity in human induced pluripotent stem cell derived neurons.Principal Investigator

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Uptake and elimination of sevoflurane in rabbit tissues-An in vivo 19F magnetic resonance studyPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

エンドトキシンショックにおける呼気中一酸化窒素濃度と重症度の関連についてPrincipal Investigator

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Principal Investigator

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MAKITA Koshi 槇田浩史

槇田浩史マキタヒロシ

槙田浩史マキタコウシ

まき田浩史マキタコウシ