SHIBASAKI Hiromi 柴崎浩美

… Alternative Names

柴崎浩美シバサキヒロミ

柴〓浩美シバサキヒロミ

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Researcher Number	20206121
Other IDs	https://orcid.org/0000-0002-9062-7370
Affiliation (Current)	2024: 東京薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2004 – 2006: 東京薬科大学, 薬学部, 講師 2001 – 2002: 東京薬科大学, 薬学部, 講師 1995 – 2000: 東京薬科大学, 薬学部, 助手 1991 – 1993: 東京薬科大学, 薬学部, 助手
Review Section/Research Field	Except Principal Investigator 応用薬理学・医療系薬学 / Physical pharmacy / Medical pharmacy / Chemical pharmacy
Keywords	Except Principal Investigator GC-MS / cortisone / cortisol / GC-MS-SIM / 体内動態 / コルチゾン / コルチゾール / hypertension / GC-MS分析 / MS … More / GC / 安定同位体標識体 / Urocanic Acid / 安定同位体 / ウロカニン酸 / stable isotope methodology / 11β-HSD2酵素活性評価 / 安定同位体標識 / 6β-hydroxycortisol / corticosteroids / cortisol ratio / urinary cortisone / 高血圧 / 速度論的解析 / 安定同位体トレーサー法 / Stable Isotopes / In Vivo Enzyme Activities / Histidine Ammonia-Lyase / 代謝異常症 / in vivo酵素活性 / L-ヒスチジン / Pharmacokinetics / L-Histidine / 脱離反応 / ヒスチジンアンモニア・リアーゼ / 酵素反応機構 / _L-ヒスチジン / renal disease / 11β-activity / グリチルリチン酸 / 11β-HSD2の酵素活性 / 腎疾患患者 / F比 / 尿中E / 11β-HSD2酵素活性 / pharmacokinetic analysis / 13C_4-and 2H_1-label / 11β-HSD activity / 速度論解析 / ^<13>C及び^2H標識 / 11β-HSD活性 / indan synthon method / stable isotopes / carbone-13 / deuterium / prednisolone / indan法 / carbon-13 / pharmacokinetics / 11β-HSD actitity / stabel isotope methodology / IIβ-HSD / 重水素標識体 / ヒト in vivo 酵素活性 / GC-MS 分析 / ヒトin vivo酵素活性 / 尿中代謝物 / 重水素標識コルチゾン / 重水素標識コルチゾール / 高血圧症 / cortisol濃度比 / 尿中cortisone / 11β-HSD酵素活性 / Metabolism / In Vivo Enzyme Mechanism / 代謝 / in vivo酵素反応機構 / ヒスチジンアンモニアリアーゼ / Metabolic Disorders / _L-Histidine / 酵素反応 / 同位体希釈質量分析 / 安定同位体標識体合成 / Prednisone / Prednisolone / Cortisone / Cortisol / Deuterium labeling / Stable isotopes / ステロイドホルモン分泌異常機構 / GC‐MS法 / 小児ネフローゼ患者 / プレドニゾン / プレドニゾロン / 安定同位体標識ステロイド / Deuterium Isotope Effect / Reversibility / Rate-limiting Step / Enzymatic Reaction / beta-Elimination / Histidine Ammonia-lyase / 同位体効果 / histidine ammoniaーlyase / urocanic acid / Lーhistidine / 重水素同位体効果 / 律速段階 / β‐脱離反応 / L‐ヒスチジン / 重水素-水素交換 / 可逆反応性 / β-脱離反応 / ヒスチジンアンモニア・リアーゼ Less

Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Sciences
Enantioselective synthesis of glucocorticoids by the indan synthon method and its application to the preparation of the multi-labeled glucocorticoids with stable isotopes
- Principal Investigator
  
  FURUTO Takashi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and life Science
A New Method for Assessing the In Vitro and In Vivo Enzyme Reaction Mechanisms Using Stable Isotope Methodology
- Principal Investigator
  
  FURUTA Takashi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and Life Science
A New Assessment of In Vivo Enzyme Activities in Metbolic Disorders Using Stable Isotope Methodology
- Principal Investigator
  
  FURUTA Takashi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and Life Science
Mechanistic Study on the Cortisol Metabolism and Secretion in the Endocrinological Disorders
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo College of Pharmacy
Study on the Enzymatic Reaction Mechanism catalyzed by Histidine Ammonia-Lyase Using Stable Isotope Methodology
- Principal Investigator
  
  FURUTA Takashi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo College of Pharmacy

All 2005

All Journal Article

[Journal Article] Use of 11α-deuterium labeled cortisol as a tracer for assessing reduced 11β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject2005
- Author(s)
  Kasuya Y, Yokokawa A, Takashima S, Furuta T, Shibasaki H
- Journal Title
  
  Steroids 70・2
  
  Pages: 117-125
- Data Source
  KAKENHI-PROJECT-16590126
[Journal Article] Use of 11 a-deuterium labeled cortisol as a tracer for assessing reduced 11 β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject.2005
- Author(s)
  Y.Kasuya, A.Yokokawa, S.Takashima, H.Shibasaki, T.Futruta
- Journal Title
  
  Steroids 70-2
  
  Pages: 117-125
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590126
[Journal Article] Validation of the plasma half-life of 11α-deuterium cortisol as a sensitive indexr for the analysis of 11β-HSD2 activity in vivo.2005
- Author(s)
  Kasuya Y, Yokokawa A, Hamura K, Shibasaki H, Furuta T
- Journal Title
  
  Steroids 70・12
  
  Pages: 811-816
- Data Source
  KAKENHI-PROJECT-16590126
[Journal Article] Validation of the plasma half-life of 1la-deuterium cortisol as a sensitive index for the analysis of human 11β-HSD2 activity in vivo.2005
- Author(s)
  Y.Kasuya, A.Yokokawa, K.Hamura, H.Shibasaki, T.Futruta
- Journal Title
  
  Steroids 70-12
  
  Pages: 811-816
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590126

1. FURUTA Takashi (70120152)

# of Collaborated Projects: 8 results

# of Collaborated Products: 2 results
2. KASUYA Yasuji (90096686)

# of Collaborated Projects: 8 results

# of Collaborated Products: 4 results
3. YOKOKAWA Akitomo (70328558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

SHIBASAKI Hiromi 柴崎 浩美

柴崎 浩美 シバサキ ヒロミ

柴〓 浩美 シバサキ ヒロミ

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[Journal Article] Use of 11α-deuterium labeled cortisol as a tracer for assessing reduced 11β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject2005

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[Journal Article] Use of 11 a-deuterium labeled cortisol as a tracer for assessing reduced 11 β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject.2005

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[Journal Article] Validation of the plasma half-life of 11α-deuterium cortisol as a sensitive indexr for the analysis of 11β-HSD2 activity in vivo.2005

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[Journal Article] Validation of the plasma half-life of 1la-deuterium cortisol as a sensitive index for the analysis of human 11β-HSD2 activity in vivo.2005

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SHIBASAKI Hiromi 柴崎浩美

柴崎浩美シバサキヒロミ

柴〓浩美シバサキヒロミ