SHIBASAKI Hiromi 柴崎浩美

… Alternative Names

柴崎浩美シバサキヒロミ

柴〓浩美シバサキヒロミ

Less

Researcher Number	20206121
Other IDs	https://orcid.org/0000-0002-9062-7370
Affiliation (Current)	2025: 東京薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 東京薬科大学, 薬学部, 准教授 2004 – 2006: 東京薬科大学, 薬学部, 講師 2001 – 2002: 東京薬科大学, 薬学部, 講師 1995 – 2000: 東京薬科大学, 薬学部, 助手 1991 – 1993: 東京薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related Except Principal Investigator 応用薬理学・医療系薬学 / Physical pharmacy / Medical pharmacy / Chemical pharmacy
Keywords	Principal Investigator LC-MS/MS / 6β-hydroxycortisol / コルチゾール / シトクロムP450 3A / 薬物代謝酵素活性評価 Except Principal Investigator GC-MS / cortisone / cortisol / GC-MS-SIM / 体内動態 … More / コルチゾン / コルチゾール / hypertension / GC-MS分析 / MS / GC / 安定同位体標識体 / Urocanic Acid / 安定同位体 / ウロカニン酸 / stable isotope methodology / 11β-HSD2酵素活性評価 / 安定同位体標識 / 6β-hydroxycortisol / corticosteroids / cortisol ratio / urinary cortisone / 高血圧 / 速度論的解析 / 安定同位体トレーサー法 / Stable Isotopes / In Vivo Enzyme Activities / Histidine Ammonia-Lyase / 代謝異常症 / in vivo酵素活性 / L-ヒスチジン / Pharmacokinetics / L-Histidine / 脱離反応 / ヒスチジンアンモニア・リアーゼ / 酵素反応機構 / _L-ヒスチジン / renal disease / 11β-activity / グリチルリチン酸 / 11β-HSD2の酵素活性 / 腎疾患患者 / F比 / 尿中E / 11β-HSD2酵素活性 / pharmacokinetic analysis / 13C_4-and 2H_1-label / 11β-HSD activity / 速度論解析 / ^<13>C及び^2H標識 / 11β-HSD活性 / indan synthon method / stable isotopes / carbone-13 / deuterium / prednisolone / indan法 / carbon-13 / pharmacokinetics / 11β-HSD actitity / stabel isotope methodology / IIβ-HSD / 重水素標識体 / ヒト in vivo 酵素活性 / GC-MS 分析 / ヒトin vivo酵素活性 / 尿中代謝物 / 重水素標識コルチゾン / 重水素標識コルチゾール / 高血圧症 / cortisol濃度比 / 尿中cortisone / 11β-HSD酵素活性 / Metabolism / In Vivo Enzyme Mechanism / 代謝 / in vivo酵素反応機構 / ヒスチジンアンモニアリアーゼ / Metabolic Disorders / _L-Histidine / 酵素反応 / 同位体希釈質量分析 / 安定同位体標識体合成 / Prednisone / Prednisolone / Cortisone / Cortisol / Deuterium labeling / Stable isotopes / ステロイドホルモン分泌異常機構 / GC‐MS法 / 小児ネフローゼ患者 / プレドニゾン / プレドニゾロン / 安定同位体標識ステロイド / Deuterium Isotope Effect / Reversibility / Rate-limiting Step / Enzymatic Reaction / beta-Elimination / Histidine Ammonia-lyase / 同位体効果 / histidine ammoniaーlyase / urocanic acid / Lーhistidine / 重水素同位体効果 / 律速段階 / β‐脱離反応 / L‐ヒスチジン / 重水素-水素交換 / 可逆反応性 / β-脱離反応 / ヒスチジンアンモニア・リアーゼ Less

臨床で利用可能なCYP3A活性評価法と活性に基づく個別化投与設計アルゴリズム構築Principal Investigator
- Principal Investigator
  
  柴崎浩美
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Sciences
Enantioselective synthesis of glucocorticoids by the indan synthon method and its application to the preparation of the multi-labeled glucocorticoids with stable isotopes
- Principal Investigator
  
  FURUTO Takashi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and life Science
A New Method for Assessing the In Vitro and In Vivo Enzyme Reaction Mechanisms Using Stable Isotope Methodology
- Principal Investigator
  
  FURUTA Takashi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and Life Science
A New Assessment of In Vivo Enzyme Activities in Metbolic Disorders Using Stable Isotope Methodology
- Principal Investigator
  
  FURUTA Takashi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and Life Science
Mechanistic Study on the Cortisol Metabolism and Secretion in the Endocrinological Disorders
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo College of Pharmacy
Study on the Enzymatic Reaction Mechanism catalyzed by Histidine Ammonia-Lyase Using Stable Isotope Methodology
- Principal Investigator
  
  FURUTA Takashi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo College of Pharmacy

All 2005

All Journal Article

[Journal Article] Use of 11α-deuterium labeled cortisol as a tracer for assessing reduced 11β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject2005
- Author(s)
  Kasuya Y, Yokokawa A, Takashima S, Furuta T, Shibasaki H
- Journal Title
  
  Steroids 70・2
  
  Pages: 117-125
- Data Source
  KAKENHI-PROJECT-16590126
[Journal Article] Use of 11 a-deuterium labeled cortisol as a tracer for assessing reduced 11 β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject.2005
- Author(s)
  Y.Kasuya, A.Yokokawa, S.Takashima, H.Shibasaki, T.Futruta
- Journal Title
  
  Steroids 70-2
  
  Pages: 117-125
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590126
[Journal Article] Validation of the plasma half-life of 11α-deuterium cortisol as a sensitive indexr for the analysis of 11β-HSD2 activity in vivo.2005
- Author(s)
  Kasuya Y, Yokokawa A, Hamura K, Shibasaki H, Furuta T
- Journal Title
  
  Steroids 70・12
  
  Pages: 811-816
- Data Source
  KAKENHI-PROJECT-16590126
[Journal Article] Validation of the plasma half-life of 1la-deuterium cortisol as a sensitive index for the analysis of human 11β-HSD2 activity in vivo.2005
- Author(s)
  Y.Kasuya, A.Yokokawa, K.Hamura, H.Shibasaki, T.Futruta
- Journal Title
  
  Steroids 70-12
  
  Pages: 811-816
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590126

1. FURUTA Takashi (70120152)

# of Collaborated Projects: 8 results

# of Collaborated Products: 2 results
2. KASUYA Yasuji (90096686)

# of Collaborated Projects: 8 results

# of Collaborated Products: 4 results
3. YOKOKAWA Akitomo (70328558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 三宅映己 (80573659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIBASAKI Hiromi 柴崎 浩美

柴崎 浩美 シバサキ ヒロミ

柴〓 浩美 シバサキ ヒロミ

Research Projects

Research Products

Co-Researchers

臨床で利用可能なCYP3A活性評価法と活性に基づく個別化投与設計アルゴリズム構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Use of 11α-deuterium labeled cortisol as a tracer for assessing reduced 11β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject2005

Author(s)

Journal Title

Data Source

[Journal Article] Use of 11 a-deuterium labeled cortisol as a tracer for assessing reduced 11 β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Validation of the plasma half-life of 11α-deuterium cortisol as a sensitive indexr for the analysis of 11β-HSD2 activity in vivo.2005

Author(s)

Journal Title

Data Source

[Journal Article] Validation of the plasma half-life of 1la-deuterium cortisol as a sensitive index for the analysis of human 11β-HSD2 activity in vivo.2005

Author(s)

Journal Title

Description

Data Source

SHIBASAKI Hiromi 柴崎浩美

柴崎浩美シバサキヒロミ

柴〓浩美シバサキヒロミ