NIWA Toshimitsu 丹羽利充

… Alternative Names

丹羽利充ニワトシミツ

丹羽利允ニワトシミツ

丹羽利光ニワトシミツ

舟羽利充ニワトシミツ

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Researcher Number	20208268
Other IDs
Affiliation (Current)	2025: 修文大学, 医療科学部, 教授
Affiliation (based on the past Project Information) *help	2021: 修文大学, 医療科学部, 教授 2018 – 2020: 修文大学, 看護学部, 教授 2002 – 2005: 名古屋大学, 医学部附属病院, 助教授 1992 – 2000: 名古屋大学, 医学部, 助教授 1993: Nagoya University, School of Medicine, Associate Professor 1991: 名古屋大学, 医学部, 構師
Review Section/Research Field	Principal Investigator Kidney internal medicine / 老化(加齢) / Kidney internal medicine Except Principal Investigator Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 質量分析法 / 脳 / diabetes mellitus / 3-deoxyglucosone / 3-デオキシグルコソン / 腎不全 / ガスクロマトグラフィー / uremia / AGE / 糖尿病 … More / 糖尿病性腎症 / メイラード反応 / N-メチルノルサルソリノール / N-メチルサルソリノール / N-メチルドーパミン / テトラヒドロイソキノリン / MPTP類似物質 / パーキンソン病 / anti-hyperuricemia drug / genetic analysis / renal hypouricemia / urate transport / renal tubule / URAT1 / トランスポーター / 尿酸 / 高尿酸血症治療薬 / 遺伝子解析 / 腎性低尿酸血症 / 尿酸輸送体 / 腎尿細管 / indoxyl sulfate / protein metabolite theory / organic anion transporter / progression of renal failure / TGF-β / 蛋白代謝物説 / 有機アニオントランスポーター / 腎不全進行 / インドキシル硫酸 / peritoneal dialysis / 酸化ストレス / グルタチオンペルオキシダーゼ / 腹膜透析 / amyloid / imidazolone / 動脈硬化 / 透析アミロイドーシス / カルボキシメチルリシン / アミロイド / イミダゾロン / diabetic nephropathy / mass spectrometry / gas chromatography / Maillard reaction / HPLC / 電気泳動 / グルコース / 架橋重合 / タンパク質 / 糖尿病患者 / 質量分析 / Akt基質蛋白 / Retシグナル伝達 / 腎臓発生 / ウレアーゼ / 乳酸菌 / 遺伝子組み替え / メサンギウム細胞 / 遺伝子多系性 / グルタミン連続配列 / ミトコンドリア呼吸抑制 / 神経毒性 / 1-フェニル-N-メチルTIQ / MS / GC / MPTP / 1-フェニルNMTIQ / 1-フェニルTIQ / マイクロダイアリシス / ガスマロマトグラフィ- / Nーメチルサルソリノ-ル / Nーメチルノルサルソリノ-ル / テトラヒドロイソキノリン(TIQ) / MPTP類析物質 / パ-キンソン病 … More Except Principal Investigator 尿毒素 / 動脈硬化 / 動脈石灰化 / インフラマソーム / 尿毒症性心筋症 / Notchシグナル / インドキシル硫酸 Less

Pathophysiology of vascular injury via Notch signaling and metabolic reprogramming by urea toxins.
- Principal Investigator
  
  Takeshita Kyosuke
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Saitama Medical University
腎臓発生に重要なRetシグナル伝達下流で活性化される新規Akt基質蛋白の機能解析Principal Investigator
- Principal Investigator
  
  丹羽利充
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Nagoya University
Identification of urate transporter, genetic analysis of renal hypouricemia and the development of anti-hyperuricemia drugPrincipal Investigator
- Principal Investigator
  
  NIWA Toshimitsu
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Nagoya University
遺伝子組み換え乳酸菌の作製とその腎不全治療への応用Principal Investigator
- Principal Investigator
  
  丹羽利充 (丹羽利允)
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Nagoya University
Induction of cellualar dysfunction by 3-deoxyglucosome as a mechanism of uremic and diabetic complicationsPrincipal Investigator
- Principal Investigator
  
  NIWA Toshimitsu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Kidney internal medicine
- Research Institution
  NAGOYA UNIVERSITY
Stimulating effect of indoxyl sulfate on progression of renal failure and development of an inhibitor of its productionPrincipal Investigator
- Principal Investigator
  
  NIWA Toshimitsu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Kidney internal medicine
- Research Institution
  NAGOYA UNIVERSITY
腎メサンギウム細胞におけるグルタミン連続配列遺伝子のクローニングPrincipal Investigator
- Principal Investigator
  
  丹羽利充
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Nagoya University
Role of 3-deoxyglucosone in the pathogenesis of uremic and diabetic complicationsPrincipal Investigator
- Principal Investigator
  
  NIWA Toshimitsu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Nagoya University
新規TIQ関連化合物の検出と細胞死の機序の解明Principal Investigator
- Principal Investigator
  
  丹羽利光
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
テトラヒドロイソキノリン関連化合物による細胞死に関する研究Principal Investigator
- Principal Investigator
  
  丹羽利充
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
内因性MPTP類似化合物であるTIQ関連化合物の代謝と病因論的意義に関する研究Principal Investigator
- Principal Investigator
  
  丹羽利充
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
内因性MPTP類以物質であるTIQ関連化合物の代謝と神経毒性に関する研究Principal Investigator
- Principal Investigator
  
  丹羽利充
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
Mass spectrometric analysis of crosslinker of aging proteins formed by Maillard reactionPrincipal Investigator
- Principal Investigator
  
  NIWA Toshimitsu
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Nagoya University
内因性MPTP類似物質であるテトラヒドロイソキノリンの代謝と神経毒性に関する研究Principal Investigator
- Principal Investigator
  
  舟羽利充
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University

All 2022 2020 2004 2003 2002

All Journal Article

[Journal Article] Indoxyl Sulfate Activates NLRP3 Inflammasome to Induce Cardiac Contractile Dysfunction Accompanied by Myocardial Fibrosis and Hypertrophy2022
- Author(s)
  Yamaguchi Kazutoshi、Yisireyili Maimaiti、Goto Sumie、Cheng Xian Wu、Nakayama Takayuki、Matsushita Tadashi、Niwa Toshimitsu、Murohara Toyoaki、Takeshita Kyosuke
- Journal Title
  
  Cardiovascular Toxicology
  
  Volume: 22 Issue: 4 Pages: 365-377
- DOI
  10.1007/s12012-021-09718-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02729, KAKENHI-PROJECT-20K08711
[Journal Article] Indoxyl Sulfate-induced Vascular Calcification is mediated through Altered Notch Signaling Pathway in Vascular Smooth Muscle Cells2020
- Author(s)
  Yamaguchi Kazutoshi、Yisireyili Maimaiti、Goto Sumie、Kato Katsuhiro、Cheng Xian Wu、Nakayama Takayuki、Matsushita Tadashi、Niwa Toshimitsu、Murohara Toyoaki、Takeshita Kyosuke
- Journal Title
  
  International Journal of Medical Sciences
  
  Volume: 17 Issue: 17 Pages: 2703-2717
- DOI
  10.7150/ijms.43184
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08711, KAKENHI-PROJECT-18H02729
[Journal Article] Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs.2004
- Author(s)
  Hasannejad H, Takeda M, ‥Niwa T, ‥Endou H.
- Journal Title
  
  Eur J Pharmacol. 499(1-2)
  
  Pages: 45-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Interactions of human organic anion transporters with diuretics.2004
- Author(s)
  Hasanne jad H, Takeda M, Taki K, Shin HJ, Babu E, Jutabha P, Khamdang S, Aleboyeh M, Onozato ML, Tojo A, Enomoto A, Anzai N, Narikawa S, Huang XL, Niwa T, Endou H
- Journal Title
  
  J Pharmacol Exp The 308(3)
  
  Pages: 1021-1029
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs.2004
- Author(s)
  Hasannejad H, Takeda M, Narikawa S, Huang XL, Enomoto A, Taki K, Niwa T, Jung SH, Onozato ML, Tojo A, Endou H.
- Journal Title
  
  Eur.J.Pharmacol. 499(1-2)
  
  Pages: 45-51
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Interactions of human organic anion transporters with diuretics.2004
- Author(s)
  Hasannejad H, Takeda M, ……Niwa T, Endou H
- Journal Title
  
  Pharmacol Exp The 308(3)
  
  Pages: 1021-1029
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs.2004
- Author(s)
  Hasanne jad H, Takeda M, Narikawa S, Huang XL, Enomoto A, Taki K, Niwa T, Jung SH, Onozato ML, Tojo A, Endou H.
- Journal Title
  
  Eur J Phannacol. 499(1-2)
  
  Pages: 45-51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Interactions of human organic anion transporters with diuretics.2004
- Author(s)
  Hasannejad H, Takeda M, Taki K, Jung SH, Babu E, Jutabha P, Khamdang S, Aleboyeh M, Onozato ML, Tojo A, Enomoto A, Anzai N, Narikawa S, Huang XL, Niwa T, Endou H
- Journal Title
  
  Pharmacol Exp The 308(3)
  
  Pages: 1021-1029
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Interactions of human organic anion as well as cation transporters with indoxyl sulfate.2003
- Author(s)
  Enomoto A, Takeda M, ……Niwa T, Endou H
- Journal Title
  
  Eur J Pharmacol. 466
  
  Pages: 13-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Interactions of human organic anion as well as cation transporters with indoxyl sulfate.2003
- Author(s)
  Enomoto A, Takeda M, Taki K, Takayama F, Noshiro R, Niwa T, Endou H
- Journal Title
  
  Eur J Phannacol. 466
  
  Pages: 13-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Molecular identification of a novel carnitine transporter specific to human testis : Insights into the mechanism of carnitine recognitiio2002
- Author(s)
  Enomoto A, Wempe MF, …Niwa T, ………Endou H
- Journal Title
  
  J Biol Chem 277(39)
  
  Pages: 36262-36271
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Role of organic anion transporters in the tubular transport of indoxyl dulfate and the induction of its nephrotoxicity.2002
- Author(s)
  Enomoto A, Takeda M, Tojo A, Sekine T, Cha SH, Khamdang S, Takayama F, Aoyama I, Nakamura S, Endou H, Niwa T
- Journal Title
  
  J Am Soc Nephrol 13
  
  Pages: 1711-1720
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Role of organic anion transporters in the tubular transport of indoxyl dulfate and the induction of its nephrotoxicity.2002
- Author(s)
  Enomoto A, Takeda M, ………Endou H, Niwa T
- Journal Title
  
  J Am Soc Nephrol 13
  
  Pages: 1711-1720
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Molecular identification of a renal urate anion exchanger that regulates blood urate levels.2002
- Author(s)
  Enomoto A, Kimira H, Chairoungdua A, Shigeta Y, Jutabha P, Ho Cha S, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Ehdou H
- Journal Title
  
  Nature 417(6887)
  
  Pages: 447-452
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Molecular identification of a renal urate anion exchanger that regulates blood urate levels.2002
- Author(s)
  Enomoto A, Kimura H, …Niwa T, Kanai Y, Endou H
- Journal Title
  
  Nature 417(6887)
  
  Pages: 447-452
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370318
[Journal Article] Molecular identification of a novel camitine transporter specific to human testis : Insights into the mechanism of camitine recognition.2002
- Author(s)
  Enomoto A, Wempe MF, Tsuchida H, Shin HJ, Cha SH, Anzai N, Goto A, Sakamoto A, Niwa T, Kanai Y, Anders MW, Endou H
- Journal Title
  
  J Biol Chem 277(39)
  
  Pages: 36262-26271
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370318

1. 永津俊治 (40064802)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. 宮崎高志

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. NAGAYA Takashi (80262913)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Takeshita Kyosuke (70444403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 神部福司 (00211871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 村田善晴 (80174308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 高橋雅英 (40183446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 片岡浩巳 (80398049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中山享之 (00456659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 佐藤稔 (70449891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 松下正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NIWA Toshimitsu 丹羽 利充

丹羽 利充 ニワ トシミツ

丹羽 利允 ニワ トシミツ

丹羽 利光 ニワ トシミツ

舟羽 利充 ニワ トシミツ

Research Projects

Research Products

Co-Researchers

Pathophysiology of vascular injury via Notch signaling and metabolic reprogramming by urea toxins.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腎臓発生に重要なRetシグナル伝達下流で活性化される新規Akt基質蛋白の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of urate transporter, genetic analysis of renal hypouricemia and the development of anti-hyperuricemia drugPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

遺伝子組み換え乳酸菌の作製とその腎不全治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction of cellualar dysfunction by 3-deoxyglucosome as a mechanism of uremic and diabetic complicationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Stimulating effect of indoxyl sulfate on progression of renal failure and development of an inhibitor of its productionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腎メサンギウム細胞におけるグルタミン連続配列遺伝子のクローニングPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of 3-deoxyglucosone in the pathogenesis of uremic and diabetic complicationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規TIQ関連化合物の検出と細胞死の機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

テトラヒドロイソキノリン関連化合物による細胞死に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

内因性MPTP類似化合物であるTIQ関連化合物の代謝と病因論的意義に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

内因性MPTP類以物質であるTIQ関連化合物の代謝と神経毒性に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Mass spectrometric analysis of crosslinker of aging proteins formed by Maillard reactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

NIWA Toshimitsu 丹羽利充

丹羽利充ニワトシミツ

丹羽利允ニワトシミツ

丹羽利光ニワトシミツ

舟羽利充ニワトシミツ