Okuya Shigeru 奥屋茂

… Alternative Names

奥屋茂オクヤシゲル

OKUYA Shigeru 奥屋茂

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Researcher Number	20214083
Other IDs
Affiliation (Current)	2025: 山陽小野田市立山口東京理科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 山口大学, 教育・学生支援機構, 教授 2018 – 2019: 山口大学, 大学教育機構, 教授 2010: Yamaguchi University, 准教授 2009: Yamaguchi University, 大学教育機構, 准教授 2008: Yamaguchi University, 大学院・医学系研究科, 准教授 … More 2006: Yamaguchi University, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授 2005: 山口大学, 大学院・医学系研究科, 助教授 2004: Yamaguchi University, Graduate School of Medicine, Associate Professor, 大学院・医学研究科, 助教授 2003: 山口大学, 医学部附属病院, 講師 1999 – 2000: Yamaguchi University School of Medicine, Research Associate,, 医学部, 助手 1994: 山口大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related / Metabolomics Except Principal Investigator 内分泌・代謝学 / Basic Section 58070:Lifelong developmental nursing-related
Keywords	Principal Investigator GLUT4 / インスリン / 膵α細胞 / グルカゴン / adipocyte / insulin / glucose uptake / adaptor protein / recycling / translocation … More / 脂肪細胞 / 糖取り込み / アダプター蛋白 / リサイクリング / トランスロケーション / SHIP(SH2-containing inositol 5'-phosphatase) / GLUT4 translocation / 交感神経系 / 神経ネットワーク / 褐色脂肪細胞 / 高蛋白 / 新生 / 高蛋白質 / 低炭水化物 / ANK structure / アンキリン構造 / glucose transporter / 糖輸送担体 / PI 3, 4-P_2 / PI 3, 4, 5-P_3 / phosphatidylinositol 3-kinase / phosphatidylinositol / insulin-induced glucose uptake / SHIP(SH2-containing inositol 5-phosphatase) / PI(3,4)P_2 / PI(3,4,5)P_3 / GLUT4translocation / SHIP (SH2-containing inositol 5'-phosphatase) / PI 3,4,5-P_3 / PI 3,4-P_2 / PI 3,4,5-p_3 / phosphatidylinositol-3-kinase / フォスファチジルイノシトール / インスリン依存性糖取り込み / 蛋白 / 糖取り込み調節 / 蛋白質 / 糖尿病 … More Except Principal Investigator PDK1 / Grp1 / Akt / GLUT4 / インスリン / 支援 / 運動 / 職域 / がんサバイバー / 女性 / PH domain / PI3 kinase / Glucose transport / Insulin / ARNO / P13キナーゼ / PHドメイン / PI3キナーゼ / 糖輸送 / dot blot hybridization / gene mutation / mitochondrial gene / insulin secretion / diabetes mellitus / グルコキナーゼ / ミトコンドリア / 遺伝子異常 / 糖尿病 / Kチャネル / グリセロールリン酸シャトル / インスリン分泌 / ミトコンドリア遺伝子 / fructose transport / molecular engineering / glucose transport / glucose transporter / フルクトース輸送 / 遺伝子工学 / グルコース輸送 / 糖輸送担体 Less

女性のがんサバイバーを対象とする職域での運動促進プログラムの作成と実施の試み
- Principal Investigator
  
  上田真寿美
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58070:Lifelong developmental nursing-related
- Research Institution
  Yamaguchi University
臓器間ネットワークによる膵α細胞新生機構と代謝制御の解明Principal Investigator
- Principal Investigator
  
  奥屋茂
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Yamaguchi University
Elucidation of the mechanism of pancreatic alfa cell mass increase and white adipocyte browning induced by a low-carbohydrate/high-protein dietPrincipal Investigator
- Principal Investigator
  
  Okuya Shigeru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Yamaguchi University
新規GLUT4結合蛋白による新たなインスリン依存性糖取り込み調節機構の解明Principal Investigator
- Principal Investigator
  
  奥屋茂
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Yamaguchi University
The analysis of a GLUT4 binding ANK structure protein, which may facilitate insulin induced-glucose uptake.Principal Investigator
- Principal Investigator
  
  OKUYA Shigeru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Yamaguchi University
The functional analysis of a novel adaptor protein binding to GLUT4Principal Investigator
- Principal Investigator
  
  OKUYA Shigeru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Yamaguchi University
The role of phosphatidylinositol turnover on insulin-induced GLUT4 translocation and glucose uptake.Principal Investigator
- Principal Investigator
  
  OKUYA Shigeru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Yamaguchi University
Intracellular sorting of glucose transporter and insulin action
- Principal Investigator
  
  OKA Yoshitomo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  内分泌・代謝学
- Research Institution
  Yamaguchi University
MOLECULAR ANALYSIS OF STRUCTURE-FUNCTION RELATIONSHIP OF GLUCOSE TRANSPORTER AND INSULIN ACTION
- Principal Investigator
  
  OKA Yoshitomo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  YAMAGUCHI UNIVERSITY
Genes involved in insulin secretion and improvement of detection method for gene mutations in diabetic patients
- Principal Investigator
  
  OKA Yoshitomo
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Yamaguchi University School of Medicine

All 2023 2022 2021 2020 2019 2018 2009 2008 2005

All Journal Article Presentation

[Journal Article] Hachimijiogan, a traditional herbal medicine, modulates adipose cell function and ameliorates diet-induced obesity and insulin resistance in mice2023
- Author(s)
  Kagawa Syota、Tanabe Katsuya、Hiromura Makoto、Ogawa Kakuyou、Koga Takayuki、Maeda Takahiro、Amo-Shiinoki Kikuko、Ochi Hiroyuki、Ichiki Yui、Fukuyama Shogo、Suzuki Saori、Suizu Natsuki、Ohmine Takaaki、Hamachi Sakurako、Tsuneki Hiroshi、Okuya Shigeru、Sasaoka Toshiyasu、Tanizawa Yukio、Nagashima Fumihiro
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 14 Pages: 1167934-1167934
- DOI
  10.3389/fphar.2023.1167934
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08581, KAKENHI-PROJECT-23K08011, KAKENHI-PROJECT-23K10862, KAKENHI-PROJECT-23K10960, KAKENHI-PROJECT-21K07332, KAKENHI-PROJECT-21K07382
[Journal Article] Gsk-3-Mediated Proteasomal Degradation of ATF4 Is a Proapoptotic Mechanism in Mouse Pancreatic β-Cells2022
- Author(s)
  Nagao Y, Amo-Shiinoki K, Nakabayashi H, Hatanaka M, Kondo M, Matsunaga K, Emoto M, Okuya S, Tanizawa Y, Tanabe K
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 23 Issue: 21 Pages: 13586-13586
- DOI
  10.3390/ijms232113586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08581, KAKENHI-PROJECT-20K08887
[Journal Article] Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes.2021
- Author(s)
  Amo-Shiinoki K, Tanabe K, Hoshii Y, Matsui H, Harano R, Fukuda T, Takeuchi T, Bouchi R, Takagi T, Hatanaka M, Takeda K, Okuya S, Nishimura W, Kudo A, Tanaka S, Tanabe M, Akashi T, Yamada T, Ogawa Y, Ikeda E, Nagano H, Tanizawa Y.
- Journal Title
  
  JCI Insight
  
  Volume: 6 Issue: 1 Pages: 143791-143791
- DOI
  10.1172/jci.insight.143791
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09843, KAKENHI-PROJECT-19K07506, KAKENHI-PROJECT-19K09041, KAKENHI-PROJECT-20K08887, KAKENHI-PROJECT-20K08915, KAKENHI-PROJECT-20K21627, KAKENHI-PROJECT-19H01055, KAKENHI-PROJECT-18H02859, KAKENHI-PROJECT-18K08516, KAKENHI-PROJECT-19H03710
[Journal Article] An ANK structure protein p61 binding to GLUT4 facilitates insulin-induced glucose uptake.2005
- Author(s)
  Shigeru Okuya, et al.
- Journal Title
  
  Journal of the Japan Diabetes Society Vol.48,Supple.2
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590939
[Journal Article] GLUT4と結合するANK構造蛋白p61は、インスリン依存性糖取り込みを促進する2005
- Author(s)
  奥屋茂
- Journal Title
  
  糖尿病第48巻
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590939
[Presentation] 血糖制御と臓器間コミュニケーション：神経ネットワークを介した膵α細胞量の調節2023
- Author(s)
  椎木幾久子, 田部勝也, 井泉知仁, 吉村充弘, 西村渉, 今井淳太, 奥屋茂, 上田陽一, 片桐秀樹, 谷澤幸生
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08581
[Presentation] グルカゴン研究の歩みとこれからの展開：グルカゴン受容体異常症の臨床像と病態2023
- Author(s)
  田部勝也, 椎木幾久子, 奥屋茂, 谷澤幸生
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08581
[Presentation] Txnipは褐色脂肪の先天性熱産生能力を維持する2023
- Author(s)
  鄒朦, 田部勝也, 椎木幾久子, 河野大輔, 香川正太, 田口昭彦, 池田賢司, 山田哲也, 太田康晴, 奥屋茂, 北村忠弘, 増谷弘, 谷澤幸生
- Organizer
  第34回分子糖尿病学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K08581
[Presentation] Txnipはマウスにおいて先天性BAT熱産生機能を維持する2023
- Author(s)
  Zou Meng, 田部勝也, 椎木幾久子, 河野大輔, 田口昭彦, 奥屋茂, 北村忠弘, 増谷弘, 谷澤幸生
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08581
[Presentation] 機能的な膵β細胞維持に向けた膵島研究の最前線：糖尿病における膵島細胞の可塑性と脱分化2022
- Author(s)
  椎木幾久子、田部勝也、幡中雅行、奥屋茂、谷澤幸生
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08581
[Presentation] Txnipは褐色脂肪の先得的発熱活性を維持する2022
- Author(s)
  Zou Meng、田部勝也、椎木幾久子、田口昭彦、河野大輔、北村忠弘、奥屋茂、増谷弘、谷澤幸生
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08581
[Presentation] 臨床・基礎におけるグルカゴン研究の進歩：グルカゴン需要増大に対するα細胞の挙動と細胞量調節機構2022
- Author(s)
  田部勝也、椎木幾久子、谷澤幸生、奥屋茂
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08581
[Presentation] 八味地黄丸は熱産生を亢進し、抗肥満作用を有する2021
- Author(s)
  香川正太、田部勝也、廣村信、古賀貴之、椎木幾久子、鈴木早織、水津菜月、大嶺貴亮、濱地桜子、奥屋茂、木村郁子、谷澤幸生、長島史裕
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08581
[Presentation] 膵β細胞脱分化は2型糖尿病の病態進展に関連する2020
- Author(s)
  椎木幾久子、田部勝也、幡中雅行、奥屋茂、福田達也、竹内崇人、坊内良太郎、山田哲也、小川佳宏、谷澤幸生
- Organizer
  第63回日本糖尿病学会年次学術集会、大津
- Data Source
  KAKENHI-PROJECT-18K08516
[Presentation] 膵β細胞脱分化は糖尿病患者の膵β細胞不全に関連する2019
- Author(s)
  椎木幾久子、田部勝也、佐藤吉彦、駒津光久、奥屋茂、谷澤幸生
- Organizer
  第69回日本体質医学会総会、下関
- Data Source
  KAKENHI-PROJECT-18K08516
[Presentation] 高齢糖尿病患者の認知機能評価におけるMRI・MRAと早期アルツハイマー型認知症支援ソフトVSRADスコアの有用性の検討2019
- Author(s)
  奥屋茂、浅江文枝、下瀬茂美、秋山優、田部勝也、谷澤幸生、古川又一
- Organizer
  第62回日本糖尿病学会年次学術集会、仙台
- Data Source
  KAKENHI-PROJECT-18K08516
[Presentation] 健康成人における朝と夜の糖代謝の比較検討.2018
- Author(s)
  藤本留理子, 太田康晴, 松村卓郎, 田口昭彦, 山本薫, 秋山優, 竹田孔明, 奥屋茂, 谷澤幸生
- Organizer
  日本糖尿病学会中国四国地方会第56回総会
- Data Source
  KAKENHI-PROJECT-18K08516
[Presentation] 時計遺伝子E4BP4/DBPの膵β細胞における役割の解明.2018
- Author(s)
  田口昭彦, 太田康晴, 松村卓郎, 中林容子, 秋山優, 山本薫, 藤本留理子, 末冨吏佐, 柳井章江, 篠田晃, 奥屋茂, 谷澤幸生
- Organizer
  日本糖尿病学会中国四国地方会第56回総会
- Data Source
  KAKENHI-PROJECT-18K08516
[Presentation] 脂肪細胞のGlut4結合蛋白p61は、発現量変化によりインスリン依存性糖取り込みを調節する2009
- Author(s)
  奥屋茂
- Organizer
  第47回日本糖尿病学会中国四国地方会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-20591061
[Presentation] 新規Glut4結合蛋白p61は、発現量変化によりインスリン依存性糖取り込みに影響する2008
- Author(s)
  奥屋茂
- Organizer
  日本糖尿病学会中国四国地方会第46回総会
- Place of Presentation
  宇部市
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-20591061
[Presentation] インスリン依存性糖取り込みを促進するANK構造蛋白p61は、インスリン抵抗性状態では発現が低下する2008
- Author(s)
  奥屋茂
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-23
- Data Source
  KAKENHI-PROJECT-20591061

1. TANIZAWA Yukio (00217142)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. OKA Yoshitomo (70175256)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. MATSUTANI Akira (10190464)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MATSUBARA Atsushi (40311815)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. UEDA Kohei (50325221)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 井上康 (10176448)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 矢賀健 (10166473)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 田部勝也 (00397994)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
9. YOSHIDA Tuyoshi

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. EMOTO Masahiro (50294640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TSURU Masatoshi (20379960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 竹田孔明 (60467793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 浅野知一郎 (70242063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 上田真寿美 (30332810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 齊田菜穂子 (00279233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 前田訓子 (10738876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 上田毅 (90254648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ZAITU Yuzuru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TAKEUCHI Yasuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TAKEUCHI Hideo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KATAGIRI Hideki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SASAKI Terumasa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 財津謙

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. MICHAEL P.Cz

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. JAMES E.Davi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. NISHIMURA Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okuya Shigeru 奥屋 茂

奥屋 茂 オクヤ シゲル

OKUYA Shigeru 奥屋 茂

Research Projects

Research Products

Co-Researchers

女性のがんサバイバーを対象とする職域での運動促進プログラムの作成と実施の試み

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

臓器間ネットワークによる膵α細胞新生機構と代謝制御の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of pancreatic alfa cell mass increase and white adipocyte browning induced by a low-carbohydrate/high-protein dietPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規GLUT4結合蛋白による新たなインスリン依存性糖取り込み調節機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of a GLUT4 binding ANK structure protein, which may facilitate insulin induced-glucose uptake.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The functional analysis of a novel adaptor protein binding to GLUT4Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of phosphatidylinositol turnover on insulin-induced GLUT4 translocation and glucose uptake.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Intracellular sorting of glucose transporter and insulin action

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MOLECULAR ANALYSIS OF STRUCTURE-FUNCTION RELATIONSHIP OF GLUCOSE TRANSPORTER AND INSULIN ACTION

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genes involved in insulin secretion and improvement of detection method for gene mutations in diabetic patients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hachimijiogan, a traditional herbal medicine, modulates adipose cell function and ameliorates diet-induced obesity and insulin resistance in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gsk-3-Mediated Proteasomal Degradation of ATF4 Is a Proapoptotic Mechanism in Mouse Pancreatic β-Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes.2021

Author(s)

Journal Title

DOI

Okuya Shigeru 奥屋茂

奥屋茂オクヤシゲル

OKUYA Shigeru 奥屋茂