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Higuchi Kazuhide  樋口 和秀

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… Alternative Names

HIGUCHI Kazuhide  樋口 和秀

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Researcher Number 20218697
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2022: 大阪医科薬科大学, 医学部, 名誉教授
2021: 大阪医科薬科大学, 医学部, 教授
2016 – 2020: 大阪医科大学, 医学部, 教授
2007 – 2009: Osaka Medical College, 医学部, 教授
2007: 大阪医科大学, 第二内科, 教授 … More
2006 – 2007: 大阪市立大学, 大学院・医学研究科, 准教授
2006: Osaka City university, Graduate School of Medicine, Department of Gastroenterology, Associate professor, 大学院医学研究科, 准教授
2006: 大阪市立大学, 大学院医学研究科, 助教授
2002 – 2005: Osaka City university, Graduate School of Medicine, Department of Gastroenterology, associate professor, 大学院・医学研究科, 助教授
2001: Osaka City University, Graduate School of Medicine, Lucturer, 大学院・医学研究科, 講師
1998 – 2000: Osaka City University, Medical School, Lecture, 医学部, 講師
1996 – 1997: 大阪市立大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related / Gastroenterology
Except Principal Investigator
Gastroenterology / Gastroenterology / General internal medicine(including psychosomatic medicine)
Keywords
Principal Investigator
Helicobacter pylori / 癌 / 糖尿病 / O-GlcNAc修飾 / costimulatory factor / 胃炎 / 炎症 / N-アセチルグルコサミン転移酵素 / α1,6-フコース転移酵素 / 癌微小環境 … More / 糖尿病合併癌 / コアフコース修飾 / 糖転移酵素 / 糖鎖 / GSK-3β / FOX-M1 / TGF-3β / FOXM1 / O-GlcNAc 修飾 / ユビキチン化 / FBXL2 / GSK3β / NF-κB / 大腸癌 / 胃癌 / Minimal Standard terminology / Voice recognition system / Reporting System / Endoscopic findings / Endoscopy / Gastroenterology / レポーティングシステム / MST / レポーティングシステ / 音声入力システム / 消化器内視鏡システム / gastric cancer / cytokines / T cells / immune response / inflammation / Gastritis / 接着分子 / 胃粘膜 / 抗原提示細胞 / T細胞抗原レセプター / リンパ球 / 食事因子 / ODC / COX-2 / ケモプリベンション / アポトーシス / 細胞増殖 / 胃粘膜傷害 / Costimulatory Factor / 胃ガン / サイトカイン / T細胞 / 免疫応答 / Interleukin-8 / interleukin-8 / tumor necrosis factor / tumor necrosis factor-・ / アディポネクチン / アディポサイトカイン … More
Except Principal Investigator
細胞増殖 / 遺伝子治療 / サイトカイン / プロスタグランジン / 胃癌細胞 / 大腸癌細胞 / 細胞内情報伝達 / cell proliferation / Helicobacter pylori / 炎症性サイトカイン / 癌 / 進行癌 / 桂枝茯苓丸 / 牛車腎気丸 / 補中益気湯 / IL-6 / 悪液質 / 漢方薬 / 漢方薬・悪液質 / Kanpo / Oncology / Peritoneal dissemination / Gene therapy / gastrointestinal cancer / Interleukin 10 / Peritoneal mesothelail cells / VEGF / COX-2 / Interleukin(IL)-10 / interleukin / interleikin / 腹膜中皮 / 腹膜播種転移 / 消化器癌 / interleukin 10 / 腹膜中皮細胞 / Wound healing / Inflammation / Regeneration therapy / Differentiation / Mesenchymal stem cell / Inflammatory bowel disease / 抗癌剤 / 大腸癌 / Apoptosis signal-regulating kinase / MAP kinase系 / 創傷治癒 / 炎症 / 再生治療 / 分化 / 骨髄間葉系幹細胞 / 炎症性腸疾患 / cytokine / cyclooxygenase / intracellular signal transduction / arachidonic acid cascade / 転写因子 / ODC / 細胞周期 / バレット腺癌 / PPAR / アデノウィルス / アポトーシス / AP-1 / MAP kinase / アデノウイルス / COX / アラキドン酸カスケード / neutrophil / epidermal growth factor / interleukin-1beta / inflammatory cytokine / gastric mucosa / cytotoxin / 胃潰瘍 / Halicobacter pylori / 好中球 / 上皮成長因子 / インターロイキン1β / 胃粘膜 / サイトトキシン / Helicobacfer pylori / 予後 / 増殖 / イメージング / 知覚過敏性 / 感覚受容器 / 化学受容器 / 受容体 / 分子イメージング / 味覚 / 消化器病学 / 内科 / 発現抑制 / 生理活性 / 発生・分化 / 発現制御 / 細胞・組織 / 食道腺癌 / バレット食道 Less
  • Research Projects

    (13 results)
  • Research Products

    (68 results)
  • Co-Researchers

    (18 People)
  •  Elucidation of glycosyltransferase-mediated regulatory mechanism of diabetes-cancer relationship and therapeutic strategyPrincipal Investigator

    • Principal Investigator
      Higuchi Kazuhide
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka Medical and Pharmaceutical University
  •  Regulatory effects of IL-6 by Kampo preparation for cancer chemotherapy and cachexia

    • Principal Investigator
      Shizuka takao
    • Project Period (FY)
      2017 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      Osaka Medical and Pharmaceutical University
  •  Effect of elevated O-GlcNAc modification on onset of gastric and colon cancerPrincipal Investigator

    • Principal Investigator
      Higuchi Kazuhide
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka Medical College
  •  Molecular brain imaging of efferent gastrointestinal signal via bitter taste receptors and the analyses of its physiological function

    • Principal Investigator
      TOMINAGA Kazunari
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka City University
  •  The Significance of Adiponectin in Atrophic Gastritis and Gastric CarcinogenesisPrincipal Investigator

    • Principal Investigator
      HIGUCHI Kazuhide
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka Medical College
  •  Roles of prostaglandin transporters and 15-hydroxyprostaglandin dehydrogenase in the pathogenesis of gastric cancer

    • Principal Investigator
      WATANABE Toshio
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka City University
  •  Role of arachidonic acid in development of Barrett's esophagus and cancer

    • Principal Investigator
      FUJIWARA Yasuhiro
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka City University
  •  Suppression for the peritoneal dissemination from gastric cancer mediated by gene therapeutic interleukin-10 induction targeted for peritoneal mesothelial cells

    • Principal Investigator
      TOMINAGA Kazunari
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka City University
  •  Therapeutic strategy for intractable inflammatory bowel diseases by mesenchymal stem cells

    • Principal Investigator
      ARAKAWA Tetsuo
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka City University
  •  Developing a Voice Recognition System for Data Entry of Gastrointestinal Endoscopic Findings to Meet the Demands in the IT AgePrincipal Investigator

    • Principal Investigator
      HIGUCHI Kazuhide
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka City University
  •  Molecular analysis for the regulation of gastric cancer cell proliferation regarding with arachidonic acid cascade and reactive oxygen species.

    • Principal Investigator
      ARAKAWA Tetsuo
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka City University
  •  Molecular biological mechanisms of mucosal inflammation in H. pylori-induced gastritisPrincipal Investigator

    • Principal Investigator
      HIGUCHI Kazuhide
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka City University
  •  Role of Helicobacter pylori cytotoxin in the gastric mucosa

    • Principal Investigator
      ARAKAWA Tetsuo
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka City University

All 2020 2019 2018 2017 2016 2010 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation

  • [Journal Article] Enhancement of O-linked N-acetylglucosamine modification promotes metastasis in patients with colorectal cancer and concurrent type 2 diabetes mellitus.2020

    • Author(s)
      Naka, Y., Okada, T., Nakagawa, T., Kobayashi, E., Kawasaki, Y., Tanaka, Y., Tawa, H., Hirata, Y., Kawakami, K., Kakimoto, K., Inoue, T., Takeuchi, T., Fukunishi, S., Hirose, Y., Uchiyama, K., Asahi, M., and Higuchi, K.
    • Journal Title

      Oncology Letter

      Volume: 20 Pages: 1171-1178

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08344
  • [Journal Article] Augmented <i>O</i>-GlcNAcylation alleviates inflammation-mediated colon carcinogenesis via suppression of acute inflammation2018

    • Author(s)
      Hirata Y, Nakagawa T, Moriwaki K, Koubayashi E, Kakimoto K, Takeuchi T, Inoue T, Higuchi K, Asahi M
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 62 Issue: 3 Pages: 221-229

    • DOI

      10.3164/jcbn.17-106

    • NAID

      130006730767

    • ISSN
      0912-0009, 1880-5086
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08678, KAKENHI-PROJECT-16K09296
  • [Journal Article] Augmented O-GlcNAcylation alleviates inflammation-mediated colon carcinogenesis via suppression of acute inflammation2018

    • Author(s)
      Y Hirata, T Nakagawa, K Moriwaki, E Koubayashi, K Kakimoto, T Takeuchi, T Inoue, K Higuchi1 and M Asah
    • Journal Title

      J. Clin. Biochem. Nutr.

      Volume: 印刷中

    • NAID

      130006730767

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09296
  • [Journal Article] Elevated O-GlcNAcylation stabilizes FOXM1 by its reduced degradation through GSK-3beta inactivation in a human gastric carcinoma cell line, MKN45 cells2018

    • Author(s)
      Y. Inoue, K. Moriwaki, Y. Ueda, T. Takeuchi, K. Higuchi, M. Asahi
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 495 Issue: 2 Pages: 1681-1687

    • DOI

      10.1016/j.bbrc.2017.11.179

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09296
  • [Journal Article] 胃癌における15-Hydroxyprostaglandin Dehydrogenaseの意義2010

    • Author(s)
      達脇大, 谷川徹也, 渡辺俊雄, 町田浩久, 岡崎博俊, 山上博一, 斯波将次, 渡辺憲治, 富永和作、藤原靖弘、押谷伸英、六車和也、澤田鉄二、平川弘聖、樋口和秀、荒川哲男
    • Journal Title

      Progress in Medicine 30巻3号

      Pages: 791-796

    • Data Source
      KAKENHI-PROJECT-19590733
  • [Journal Article] Leptin promotes gastric ulcer healing via upregulation of vascular endothelial growth factor.2010

    • Author(s)
      Tanigawa T, Watanabe T, Otani K, Nadatani Y, Machida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T.
    • Journal Title

      Digestion 81(2)

      Pages: 86-95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590732
  • [Journal Article] Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma2010

    • Author(s)
      Tatsuwaki H、Tanigawa T, Watanabe T, Machida H, Okazaki H, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Muguruma K, Sawada T, Hirakawa K, Higuchi K, Arakawa T
    • Journal Title

      Cancer Sci Vol.101

      Pages: 550-558

    • NAID

      10026588732

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590733
  • [Journal Article] Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid.2009

    • Author(s)
      Watanabe T, Nishio H, Tanigawa T, Yamagami H, Okazaki H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Asahara T, Nomoto K, Higuchi K, Takeuchi K, Arakawa T
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 297(3)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590731
  • [Journal Article] 胃潰瘍治癒過程におけるレプチンの意義2009

    • Author(s)
      谷川徹也, 渡辺俊雄, 町田浩久, 岡崎博俊, 山上博一, 渡辺憲治, 富永和作, 藤原靖弘, 押谷伸英, 樋口和秀, 荒川哲男
    • Journal Title

      Progress in Medicine 29巻3号

      Pages: 779-781

    • Data Source
      KAKENHI-PROJECT-19590732
  • [Journal Article] Long-term efficacy of Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura: 7-year follow-up prospective study.2009

    • Author(s)
      Tsumoto C, Tominaga K, Okazaki H, Tanigawa T, Yamagami H, Watanabe K, Nakao T, Koh K, Watanabe T, Fujiwara Y, Yamane T, Oshitani N, Hino M, Higuchi K, Arakawa T
    • Journal Title

      Ann Hematol 88(8)

      Pages: 789-93

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590731
  • [Journal Article] Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent.2008

    • Author(s)
      Watanabe T, Higuchi K, et. al.
    • Journal Title

      Gut 57

      Pages: 181-187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590731
  • [Journal Article] Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats.2008

    • Author(s)
      Ochi M, Tominaga K, Tanaka F, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T
    • Journal Title

      Life Sci 82(15-16)

      Pages: 862-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590731
  • [Journal Article] Concurrent assessment of reservoir and emptying of the stomach for dyspepsia patients.2008

    • Author(s)
      Tominaga K, Higuchi K, et al.
    • Journal Title

      Hepatogastroenterology 55

      Pages: 744-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590731
  • [Journal Article] A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma2008

    • Author(s)
      Sugawa T, Fujiwara Y, Yamagami H, Watanabe K, Tanigawa T, Shiba M, Watanabe T, Tominaga K, Oshitani N, Higuchi K, Arakawa T.
    • Journal Title

      Gut 57(5)

      Pages: 575-81

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent.2008

    • Author(s)
      Watanabe T, Higuchi K, Kobata A, Nishio H, Tanigawa T, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Asahara T, Nomoto K, Takeuchi K, Arakawa T
    • Journal Title

      Gut 57(2)

      Pages: 181-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590731
  • [Journal Article] Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats2008

    • Author(s)
      Tanaka F, Tominaga K, Ochi M, Tanigawa T, Watanabe T, Fujiwara Y, Ohta K, Oshitani N, Higuchi K, Arakawa T.
    • Journal Title

      Life Sci. 83(23-24)

      Pages: 771-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Perfectionism underlying psychological background correlated with the symptoms of functional dyspepsia.2008

    • Author(s)
      Ochi M, Tominaga K, Iketani T, Kadouchi K, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Kiriike N, Arakawa T
    • Journal Title

      J Gastroenterol 43(9)

      Pages: 699-704

    • NAID

      10022609751

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590731
  • [Journal Article] Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity.2008

    • Author(s)
      Tanaka F, Tominaga K, Shiota M, Ochi M, Kuwamura H, Tanigawa T, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Iwao H, Arakawa T
    • Journal Title

      Cancer Gene Ther 15(1)

      Pages: 51-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590731
  • [Journal Article] Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent.2008

    • Author(s)
      Watanabe T, Higuchi K, et. al.
    • Journal Title

      Gut 57

      Pages: 181-187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent2008

    • Author(s)
      Watanabe T, Higuchi K, Kobata A, Nishio H, Tanigawa T, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Asahara T, Nomoto K, Takeuchi K, Arakawa T.
    • Journal Title

      Gut 57(2)

      Pages: 181-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity2008

    • Author(s)
      Tanaka F, Tominaga K, Shiota M, Ochi M, Kuwamura H, Tanigawa T, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Iwao H, Arakawa T.
    • Journal Title

      Cancer Gene Ther 15(1)

      Pages: 51-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Concurrent assessment of reservoir and emptying of the stomach for dyspepsia patients.2008

    • Author(s)
      Tominaga K, Higuchi K, Ochi M, Kadouchi K, Kawamura E, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Shiomi S, Arakawa T
    • Journal Title

      Hepatogastroenterology 55(82-83)

      Pages: 744-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590731
  • [Journal Article] Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2, 4-dihydroxypyridine on 5-FU-resistant gastric cancer cells: possible role of a dihydropyrimidine dehydrogenase-independent mechanism.2007

    • Author(s)
      Sasaki E, Tominaga K, Kuwamura H, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T
    • Journal Title

      J Gastroenterol 42(10)

      Pages: 816-22

    • NAID

      10019970653

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590731
  • [Journal Article] Roles of ZO-1 and epidermal growth factor in esophageal epithelial defense against acid2007

    • Author(s)
      Okuyama M, Fujiwara Y, Tanigawa T, Watanabe K, Shiba M, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T.
    • Journal Title

      Digestion 75(2-3)

      Pages: 135-41

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-12007

    • Author(s)
      Kuwamura H, Tominaga K, Shiota M, Ashida R, Nakao T, Sasaki E, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Ichijo H, Arakawa T, Iwao H.
    • Journal Title

      Oncol Rep 17(4)

      Pages: 781-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Comparison of gastrointestinal symptoms and psychological factors of functional dyspepsia to peptic ulcer or panic disorder patients.2007

    • Author(s)
      Tominaaa K, Higuchi K, Iketani T, Ochi M, Kadouchi K, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Nagata T, Kiriike N, Arakawa T.
    • Journal Title

      Inflammopharmacology. 15(2)

      Pages: 84-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590617
  • [Journal Article] Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2, 4-dihydroxypyridine on 5-FU-resistant gastric cancer cells : possible role of a dihydropyrimidine dehydrogenase-independent mechanism2007

    • Author(s)
      Sasaki E, Tominaga K, Kuwamura H, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T.
    • Journal Title

      J Gastroenterol 42(10)

      Pages: 816-22

    • NAID

      10019970653

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Comparison of gastrointestinal symptoms and psychological factors of functional dyspepsia to peptic ulcer or panic disorder patients.2007

    • Author(s)
      Tominaga K, Higuchi K et al.
    • Journal Title

      Inflammopharmacology 15(2)

      Pages: 84-89

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590617
  • [Journal Article] Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1.2007

    • Author(s)
      Kuwamura H, Tominaaa K, Shiota M, Ashida R, Nakao T, Sasaki E, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Ichijo H, Arakawa T, lwao H.
    • Journal Title

      Oncol Rep. 17(4)

      Pages: 781-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590617
  • [Journal Article] Feasibility, safety, and efficacy of the Stretta procedure in Japanese patients with gastroesophageal reflux disease : first report from Asia.2007

    • Author(s)
      Higuchi K, Fujiwara Y, et al.
    • Journal Title

      J Gastroenterol 42

      Pages: 205-10

    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Comparison of gastrointestinal symptoms and psychological factors of functional dyspepsia to peptic ulcer or panic disorder patients.2007

    • Author(s)
      Tominaga K, Higuchi K, et. al.
    • Journal Title

      Inflammopharmacology. 15

      Pages: 84-89

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis2006

    • Author(s)
      Hayakawa T, Fujiwara Y, Hamaguchi M, Sugawa T, Okuyama M, Sasaki E, Watanabe T, Tominaga K, Oshitani N, Higuchi K, Arakawa T.
    • Journal Title

      Gut 55(4)

      Pages: 450-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Roles of epidermal growth factor and Na+/H+ exchanger-1 in esophageal epithelial defense against acid-induced injury.2006

    • Author(s)
      Fujiwara Y, Higuchi K, et al.
    • Journal Title

      Am J Physiol 290

    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Lafutidine can improve the quality of gastric ulcer healing in humans : a randomized, controlled, multicenter trial.2006

    • Author(s)
      Higuchi K, Watanabe T, et al.
    • Journal Title

      Inflammopharmacology 14

      Pages: 226-30

    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Production of reactive oxygen species in peripheral blood is increased in individuals with Helicobacter pylori infection and decreased after its eradication.2006

    • Author(s)
      Mashimo M, Higuchi K, et al.
    • Journal Title

      Helicobacter 11

      Pages: 266-71

    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Anti-inflammatory function induced by bone marrow-derived mesenchymal stem cells for dextran sulfate sodium-induced colitis in rats.2006

    • Author(s)
      Tanaka F, Tominaga K, Ochi M, Tanigawa T, Sasaki E, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T
    • Journal Title

      Ulcer Res (in press)

      Pages: 33-33

    • NAID

      10018262341

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590675
  • [Journal Article] Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis.2006

    • Author(s)
      Hayakawa T, Fujiwara Y, Hamaguchi M, Sugawa T, Okuyama M, Sasaki E, Watanabe T, Tominaaa k, Oshitani N, Higuchi K, Arakawa T.
    • Journal Title

      Gutt. 55(4)

      Pages: 450-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590617
  • [Journal Article] Roles of epidermal growth factor and Na+/H+ exchanger-1 in esophageal epithelial defense against acid-induced injury2006

    • Author(s)
      Fujiwara Y, Higuchi K, Takashima T, Hamaguchi M, Hayakawa T, Tominaga K, Watanabe T, Oshitani N, Shimada Y, Arakawa T.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 290(4)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590696
  • [Journal Article] Roles of epidermal growth factor and Na+/H+ exchanger-1 in esophageal epithelial defense against acid-induced injury.2006

    • Author(s)
      Fujiwara Y, Higuchi K, Takashima T, Hamaguchi M, Hayakawa T, Tominaga K, Watanabe T, Oshitani N, Shimada Y, Arakawa T
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 290(4)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590675
  • [Journal Article] Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis.2006

    • Author(s)
      Hayakawa T, Fujiwara Y, Hamaguchi M, Sugawa T, Okuyama M, Sasaki E, Watanabe T, Tominaga K, Oshitani N, Higuchi K, Arakawa T
    • Journal Title

      Gut. 55(4)

      Pages: 450-456

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590675
  • [Journal Article] Developing a new Japanese MST system2005

    • Author(s)
      Shiba M, Higuchi k, et al.
    • Journal Title

      Gastroenterological Endoscopy 47

      Pages: 704-704

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590677
  • [Journal Article] MSTを用いた内視鏡所見入力システムの開発と運用について2005

    • Author(s)
      斯波将次, 樋口和秀, 門内かおり
    • Journal Title

      Gastroenterological Endoscopy Vol. 47

      Pages: 704-704

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590677
  • [Journal Article] Dominant-negative mutant of c-Jun gene transfer : a novel therapeutic strategy for colorectal cancer.2004

    • Author(s)
      Suto R, Tominaga K, Mizuguchi H, Sasaki E, Higuchi K, Kim S, Iwao H, Arakawa T
    • Journal Title

      Gene Ther. 11(2)

      Pages: 187-193

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590675
  • [Journal Article] Indomethacin, but not Helicobacter pylori, inhibits adaptive relaxation in isolated guinea-pig stomach.2004

    • Author(s)
      Higuchi K et al.
    • Journal Title

      Drugs Exp Clin Res. 30(5-6)

      Pages: 235-241

    • Data Source
      KAKENHI-PROJECT-15590675
  • [Journal Article] MSTの汎用性における問題点について2004

    • Author(s)
      斯波将次, 樋口和秀
    • Journal Title

      Gastroenterological Endoscopy Vol. 46

      Pages: 797-797

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590677
  • [Journal Article] Problems on a Japanese MST system2004

    • Author(s)
      Shiba M, Higuchi k, et al.
    • Journal Title

      Gastroenterological Endoscopy 46

      Pages: 797-797

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590677
  • [Journal Article] Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha.2004

    • Author(s)
      Watanabe T, Higuchi K et al.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 287(4)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590617
  • [Journal Article] Dominant-negative mutant of c-Jun gene transfer : a novel therapeutic strategy for colorectal cancer.2004

    • Author(s)
      Suto R, Tominaaa K, Mizuguchi H, Sasaki E, Higuchi K, Kim S, lwao H, Arakawa T.
    • Journal Title

      Gene Ther. 11(2)

      Pages: 187-93

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590617
  • [Journal Article] Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha.2004

    • Author(s)
      Watanabe T, Higuchi K, Hamaguchi M, Shiba M, Tominaga K, Fujiwara Y, Matsumoto T, Arakawa T.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 287(4)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590617
  • [Journal Article] Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha.2004

    • Author(s)
      Watanabe T, Higuchi K, Hamaguchi M, Shiba M, Tominaga K, Fujiwara Y, Matsumoto T, Arakawa T
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 287(4)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590675
  • [Journal Article] Correlation of MAP kinases with COX-2; induction differs between MKN45 and HT29 cells.2004

    • Author(s)
      Tominaaa K, Higuchi K, Sasaki E, Suto R, Watanabe T, Fujiwara Y, Oshitani N, Matsumoto T, Kim S, lwao H, Arakawa T.
    • Journal Title

      Aliment Pharmacol Ther. 20 Suppl 1

      Pages: 143-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590617
  • [Journal Article] Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells.2004

    • Author(s)
      Tominaga K, Higuchi K, Sasaki E, Suto R, Watanabe T, Fujiwara Y, Oshitani N, Matsumoto T, Kim S, Iwao H, Arakawa T
    • Journal Title

      Aliment Pharmacol Ther. 20 Suppl 1

      Pages: 143-150

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590675
  • [Journal Article] Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells.2004

    • Author(s)
      Tominaga K, Higuchi K et al.
    • Journal Title

      Aliment Pharmacol Ther 20, Suppl 1

      Pages: 143-150

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590617
  • [Journal Article] Indomethacin, but not Helicobacter pylori, inhibits adaptive relaxation in isolated guinea-pig stomach.2004

    • Author(s)
      Higuchi K et al.
    • Journal Title

      Drugs Exp Clin Res. 30(5-6)

      Pages: 235-241

    • Data Source
      KAKENHI-PROJECT-16590617
  • [Journal Article] 汎用型MST所見入力システムの開発と運用について2003

    • Author(s)
      Shiba M, Higuchi K, Kadouchi K
    • Journal Title

      第70回日本消化器内視鏡学会近畿地方会抄録集

      Pages: 51-51

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590677
  • [Journal Article] 電子カルテにおける内視鏡データおよび画像運用の問題点と将来2003

    • Author(s)
      斯波将次, 樋口和秀, ほか
    • Journal Title

      Gastroenterological Endoscopy Vol. 45

      Pages: 1836-1836

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590677
  • [Journal Article] 汎用型MST所見入力システムの開発と運用について2003

    • Author(s)
      斯波将次, 樋口和秀, 門内かおり
    • Journal Title

      第70回日本消化器内視鏡学会近畿地方会抄録集

      Pages: 51-51

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590677
  • [Journal Article] Developing a Japanese MST system2003

    • Author(s)
      Shiba M, Higuchi k, et al.
    • Journal Title

      Gastroenterological Endoscopy 45

      Pages: 1836-1836

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590677
  • [Presentation] O-GlcNAcylation stabilizes FOXM1protein Via suppression-of its poly-ubquitination2019

    • Author(s)
      Kazumasa Moriwaki,Yasuhiro Ueda,Kazuhide Higuchi,and Michio Asahi
    • Organizer
      第92回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-16K09296
  • [Presentation] Elevated O-GlcNAcylation stabilizes FoxM1 protein via suppression of its proteasomal degradation2018

    • Author(s)
      Kazumasa Moriwaki, Yasuhiro Ueda, Kazuhide Higuchi, and Michio Asahi
    • Organizer
      第77回 日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K09296
  • [Presentation] O-GlcNAcylation promotes cell proliferation through the increase of FoxM1 expression in gastric cancer cells2017

    • Author(s)
      森脇一将, 井上陽介, 樋口和秀, 朝日通雄
    • Organizer
      日本薬理学会学術総会
    • Place of Presentation
      長崎ブリックホール、他
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16K09296
  • [Presentation] O-GlcNAc糖鎖修飾の上昇は転写因子FOXM1の分解を阻害することで癌細胞の増殖を促進する2017

    • Author(s)
      森脇 一将, 井上 陽介, 上田 康裕, 樋口 和秀, 朝日 通雄
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09296
  • [Presentation] Augmented O-GlcNAcylation Alleviates Inflammation-mediated Colon Carcinogenesis via Suppression of Acute Inflammation2017

    • Author(s)
      中川孝俊, 平田好正, 森脇一将, 光林栄子, 柿本一誠, 竹内利久, 井上拓也, 樋口和秀, 朝日通雄
    • Organizer
      第132回日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-16K09296
  • [Presentation] Relationship Between Gastric Cancer and O-GlcNacylation2016

    • Author(s)
      Yosuke Inoue, Kazumasa Moriwaki, Kazuhide Higuchi, and Michio Asahi
    • Organizer
      DDW2016
    • Place of Presentation
      San Diego Convention Center
    • Year and Date
      2016-05-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09296
  • [Presentation] 胃癌における15-hydroxyprostaglandin dehydrogenaseの発現動態とその意義2008

    • Author(s)
      達脇大, 谷川徹也, 渡辺俊雄, 町田浩久, 岡崎博俊, 斯波將次, 富永和作, 伊倉義弘, 藤原靖弘, 押谷伸英, 六車一哉, 澤田鉄二, 平川弘聖, 樋口和秀, 荒川哲男
    • Organizer
      第4回日本消化管学会総会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-07
    • Data Source
      KAKENHI-PROJECT-19590733
  • [Presentation] 胃癌組織における15-Hydroxyprostaglandin dehydrogenaseの発現動態の検討2008

    • Author(s)
      達脇大, 谷川徹也, 渡辺俊雄, 町田浩久, 岡崎博俊, 斯波將次, 富永和作, 藤原靖弘, 押谷伸英, 六車一哉, 澤田鉄二, 平川弘聖, 樋口和秀, 荒川哲男
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-19590733
  • [Presentation] A novel rat model to determine the pathogenic association between reflux esophagitis and bronchial asthma2007

    • Author(s)
      Sugawa T, Fujwiara Y, Okuyama M, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T.
    • Organizer
      米国消化器病学会
    • Place of Presentation
      WA, USA
    • Year and Date
      2007-05-19
    • Data Source
      KAKENHI-PROJECT-18590696
  • [Presentation] Role of aracidonic acid metabolism in rat acid reflux esophagitis2006

    • Author(s)
      Hayakawa T, Fujiwara Y, Hamaguchi M, Sugawa T, Okuyama M, Sasaki E, Watanabe T, Tominaga K, Oshitani N, Higuchi K, Arakawa T.
    • Organizer
      米国消化器病学会
    • Place of Presentation
      LA, CA, USA
    • Year and Date
      2006-05-21
    • Data Source
      KAKENHI-PROJECT-18590696
  • 1.  FUJIWARA Yasuhiro (40285292)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 36 results
  • 2.  TOMINAGA Kazunari (80336768)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 36 results
  • 3.  WATANABE Toshio (50336773)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 39 results
  • 4.  TANIGAWA Tetsuya (70423879)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 13 results
  • 5.  ARAKAWA Tetsuo (60145779)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 6.  朝日 通雄 (10397614)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 7.  SHIBA Masatsugu (40381991)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 8.  Shizuka takao (40795267)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  後藤 昌弘 (80351419)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  紀 貴之 (80465608)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  山口 敏史 (50806841)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  宮本 敬大 (20817572)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  島本 福太郎 (70879444)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  三善 英知 (20322183)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  Takeuchi Toshihisa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 16.  Inoue Takuya
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 17.  Nakagawa Takatoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 18.  Moriwaki Kazumasa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results

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