Tsukada Junichi 塚田順一

… Alternative Names

塚田順一ツカダジユンイチ

TSUKADA Junichi 塚田順一

TSUKADA Jyunichi 塚田順一

Less

Researcher Number	20227367
Other IDs
External Links
Affiliation (Current)	2025: 産業医科大学, 大学病院, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 産業医科大学, 大学病院, 准教授 2009 – 2011: 産業医科大学, 大学病院, 准教授 2007 – 2008: 産業医科大学, 医学部, 准教授 2005 – 2006: 産業医科大学, 医学部, 助教授 2000 – 2003: Univ.of Occupational Environmental Health, School of Medicine, Associate Professor, 医学部, 助教授 1996 – 1999: 産業医科大学, 医学部, 助手 1993 – 1994: 産業医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Hematology / Hematology Except Principal Investigator 内科学一般 / 内分泌・代謝学 / Hematology / Basic Section 52010:General internal medicine-related / Hematology / Structural biochemistry
Keywords	Principal Investigator 成人T細胞白血病 / HTLV-I / Tax / MyD88 / adult T-cell leukemia / STAT / インターロイキン 1 / 成人T細胞性白血病 / インターロイキン1 / Toll-like receptor … More / Toll likeレセプター / Toll-like レセプター / リポポリサッカライド / HTLV-1 / signal transduction / leukemia / Receptor / cvtokine / gene transcription / interleukin 1 / adult T cell leukemia / インターロイキン / シグナル伝達 / 白血病 / レセプター / サイトカイン / 遺伝子転写 / Interleukin 1 / transcription / 転写 / Tax蛋白 … More Except Principal Investigator サイトカイン / ATL / 白血病 / adhesion molecules / T細胞 / ICAM-1 / CD44 / Asn-linked glycan / アスパラギン結合型糖鎖 / estrogen / androgen / bone formation / parathyroid hormone-related peptide / interleukin-6 / interleukin-4 / BDNF / インフラマゾーム / FGビーズ / ステロイド様抗がん剤 / RNASeq / ステロイド / 薬剤耐性 / organ-tropism / homing molecules / co-stimulatory molecules / integrin / endothelial cells / T cells / systemic lupus erythematosus / リンパ球 / 全身エリテマトーデス / 共刺激分子 / 臓器特異的浸潤 / 帰巣分子 / 細胞表面抗原 / インテグリン / 血管内皮細胞 / 全身性エリテマトーデス / G-CSF receptor / swainsonine / deoxynojirimycin / neutrophil maturation / G-CSF受容体 / スワンソニン / デオキシノジリマイシン / 好中球成熟 / apoptosis / cell cycle / hyaluronan / synovial cells / Rheumatoid arthritis / 細胞増殖 / 細胞死 / Fas / アポトーシス / 細胞周期 / 滑膜細胞 / ヒアルロン酸 / 接着分子 / 慢性関節リウマチ / TAX protein / IL-1 gene / Cell Adhesion Molecules / Hypercalcemia / 核内転写因子 / IL-1β遺伝子 / Tax蛋白 / G蛋白 / イソテグン / LFA-1 / 細胞接着 / TAX蛋白 / TAX蛋白質 / IL-1遺伝子 / 細胞接着分子 / 高Ca血症 / Promoter / alpha-mannosidase II^x / alpha-mannosidase II / N-glycan / アルファマンノシダーゼII^x / プロモーター / アルファマンノシダーゼII^X / アルファマンノシダーゼII / N-グリカン / bone resorption / osteoclast / エストロゲン / アンドロゲン / 骨芽細胞 / 破骨細胞 / インターロイキン-4 / bone rescrption / ostecclast / NFAT / RhoA / TrkB / Treg(制御性T細胞) / Treg / マクロファージ Less

Elucidation of the mechanism of steroid-structure anticancer drug resistance to leukemia cells and application to personalized diagnosis
- Principal Investigator
  
  中西司
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  University of Occupational and Environmental Health, Japan
BDNF produced by leukemia cells induced regulatory T cells
- Principal Investigator
  
  YOSHIDA Yasuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Occupational and Environmental Health, Japan
Effect of BDNF on proliferation of leukemic cells and application to the treatment.
- Principal Investigator
  
  YOSHIDA Yasuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Occupational and Environmental Health, Japan
Growth inhibition of adult T-cell leukemia cells through the Toll-like receptor signalingPrincipal Investigator
- Principal Investigator
  
  TSUKADA Junichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Occupational and Environmental Health, Japan
Identification of organ-specific cell surface molecules on T cells and endothelial cells in patients with systemic lupus erythematosus
- Principal Investigator
  
  TANAKA Yoshiya
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  University of Occupational and Environmental Health, Japan
Transcriptional activation of the HTLV-I gene in monocytes and macrophages.Principal Investigator
- Principal Investigator
  
  TSUKADA Junichi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Occupational and Environmental Health, Japan
The functional heterogeneity of synovial cells in patients with rheumatoid arthritis.
- Principal Investigator
  
  TANAKA Yoshiya
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  University of Occupational and Environmental Health
Studies on the biological role of N-glycan in the maturation process of neutrophilic cells
- Principal Investigator
  
  MISAGO Masahiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Occupational and Environmental Health
Constitutive activation of LIL-Stat in adult T cell leukemia cellsPrincipal Investigator
- Principal Investigator
  
  TSUKADA Junichi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Occupational and Environmental Health
(Specific Regulation of Mechanism of Hypercalcemia Induction in Adult T Cell Leukemia.)
- Principal Investigator
  
  ETO Sumiya
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Occupational and Environmental Health
Induction of Human Prointerleukin 1beta Gene by Human T-Cell Leukemia VirusPrincipal Investigator
- Principal Investigator
  
  TSUKADA Junichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Occupational and Environmental Health
Studies on the role of N-glycan by analysis of Golgi alpha-mannosidase II gene
- Principal Investigator
  
  MISAGO Masahiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Occupational and Environmental Health
  University Occupational and Environmental Health, School of Nursing and Medical Technology
Effects of Sex Hormone and Interleukin on Bone Resorption
- Principal Investigator
  
  MORIMOTO Isao
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Occupational & Environmental Health

All 2022 2011 2010 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Pentacyclic triterpenoid ursolic acid induces apoptosis with mitochondrial dysfunction in adult T-cell leukemia MT-4 cells to promote surrounding cell growth2022
- Author(s)
  Mengyue Shen, Tsukasa Nakanishi, Junichi Tsukada, Yasuhiro Yoshida,
- Journal Title
  
  Mol Onco
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07406
[Journal Article] Apoptosis induction through proteasome inhibitory activity of cucurbitacin D in human T-cell leukemia2011
- Author(s)
  Ding, N., Yamashita, U., Matsuoka, H., Sugiura, T., Tsukada, J., Noguchi, J. and Yoshida, Y.
- Journal Title
  
  Cancer
  
  Volume: 117 Issue: 12 Pages: 2735-46
- DOI
  10.1002/cncr.25711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591253
[Journal Article] The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation2011
- Author(s)
  Tsukada, J., Yoshida Y., et al
- Journal Title
  
  Cytokine
  
  Volume: 54 Pages: 6-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591253
[Journal Article] The CCAAT/enhancer(C/EBP) family of basic-leucine zipper(bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation2011
- Author(s)
  Tsukada, J., Yoshida, Y., Kominato, Y. and Auron, P. E.
- Journal Title
  
  Cytokine
  
  Volume: 54 Pages: 6-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591253
[Journal Article] Intracellular HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1.2008
- Author(s)
  Mouri, F., Tsukada, J., Mizobe, T., Higashi, T., Yoshida, Y., Minami, Y., Izumi, H., Kominato, Y., Kohno, K., Tanaka, Y.
- Journal Title
  
  Eur J Heamatology 80
  
  Pages: 10-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591147
[Journal Article] Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU.1 and non-phosphorylated Stat1 is critical for LPS induction of the IL1B gene.2007
- Author(s)
  Unlu, S., Kumar, A., Waterman, WR., Tsukada, J., Wang, KZ., Galson, DL., Auron, PE.
- Journal Title
  
  Mol Immunol 44
  
  Pages: 3364-3379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591147
[Journal Article] Auron PE Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU. 1 and non-phosphorylated Statl is critical for LPS induction of the IL1B gene.2007
- Author(s)
  Unlu S, Kumar A, Waterman WR, Tsukada J, Wang KZ, Galson DL
- Journal Title
  
  Mol Immunol. 44(13)
  
  Pages: 3364-79
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591018
[Journal Article] Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU.1 and non-phosphorylated Stat1 is critical for LPS induction of the IL1B gene.2007
- Author(s)
  Unlu S, Kumar A, Waterman WR, Tsukada J, Wang KZ, Galson DL, Auron PE
- Journal Title
  
  Mol Immunol 44(13)
  
  Pages: 3364-3379
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591018
[Journal Article] Constitutive association of MyD88 to IRAK1 in HTLV-1-transformed T-cells.2007
- Author(s)
  Mizobe, T., Tsukada, J., Higashi, T., Mouri, F., Matsuura, A., Taniguchi, R., Minami, Y., Yoshida, Y., Tanaka, Y.
- Journal Title
  
  Exp Hematology 38
  
  Pages: 1812-1822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591147
[Journal Article] Growth suppression of human mast cells expressing constitutively active c-kit receptors by JNK inhibitor SP600125.2006
- Author(s)
  Wang B, Tsukada J.Higashi T, Mizobe T, Matsuura A, Mouri F, Sawamukai N, Ra C, Tanaka Y.
- Journal Title
  
  Genes Cells. 11(9)
  
  Pages: 983-992
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591018
[Journal Article] Retrospective analysis of cord blood transplantation on 62 adult patients with advanced hematological malignancies.2006
- Author(s)
  Tamura K, Kawano F, Etoh T, Utsunomiya A, Imamura Y, Okamura S, Tsukada J, Uike N, Takamatsu Y, Kyushu Hematology Organization for Treatment Study Group.
- Journal Title
  
  Fukuoka Igaku Zasshi. 97(6)
  
  Pages: 175-182
- NAID
  120002548748
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591018
[Journal Article] Glucocorticoid inhibits the human pro-interleukin lbeta gene (ILIB) by decreasing DNA binding of transactivators to the signal-responsive enhancer2006
- Author(s)
  Waterman WR, Xu LL, Tetradis S, Motyckova G, Tsukada J, Saito K, Webb AC, Robinson DR, Auron PE.
- Journal Title
  
  Mol Immunol. 43(7)
  
  Pages: 773-782
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591018
[Journal Article] Growth suppression of human mast cells expressing constitutively active c-kit receptors by JNK inhibitor SP6001252006
- Author(s)
  Wang B, Tsukada J, Higashi T, Mizobe T, Matsuura A, Mouri F, Sawamukai N, Ra C, Tanaka Y
- Journal Title
  
  Genes Cells 11(9)
  
  Pages: 983-992
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591018
[Journal Article] Glucocorticoid inhibits the human pro-interleukin 1beta gene (ILIB) by decreasing DNA binding of transactivators to the signal-responsive enhancer.2006
- Author(s)
  Waterman WR, Xu LL, Tetradis S, Motyckova G, Tsukada J, Saito K, Webb AC, Robinson DR, Auron PE
- Journal Title
  
  Mol Immunol 43(7)
  
  Pages: 773-782
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591018
[Journal Article] Mismatch of minor histocompatibility antigen contributes to a graft-versus-leukemia effect rather than to acute GVHD, resulting in long-term survival after HLA-identical stem cell transplantation in Japan. 20062006
- Author(s)
  Katagiri T, Shiobara S, Nakao S, Wakano M, Muranaka E, Kuba N, Furukawa T, Tsukada J, Takeda H, Aizawa Y, Harada M
- Journal Title
  
  Bone Marrow Transplant. 38(10)
  
  Pages: 681-686
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591018
[Journal Article] Mismatch of minor histocompatibility antigen contributes to a graft-versus-leukemia effect rather than to acute GVHD, resulting in long-term survival after HLA-identical stem cell transplantation in Japan.2006
- Author(s)
  Katagiri T, Shiobara S, Nakao S, Wakano M, Muranaka E, Kuba N, Furukawa T, Tsukada J, Takeda H, Aizawa Y, Harada M.
- Journal Title
  
  Bone Marrow Transplant. 38(10)
  
  Pages: 681-686
- NAID
  120000809813
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591018
[Journal Article] Kyushu Hematology Organization for Treatment Study Group. Retrospective analysis of cord blood transplantation on 62 adult patients with advanced hematological malignancies.2006
- Author(s)
  Tamura K, Kawano F, Etoh T, Utsunomiya A, Imamura Y, Okamura S, Tsukada J, Uike N, Takamatsu Y
- Journal Title
  
  Fukuoka Igaku Zasshi. 97(6)
  
  Pages: 175-82
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591018
[Journal Article] Constitutive tyrosine and serine phosphorylation of STAT4 in T-cells transformed with HTLV-I2005
- Author(s)
  Higashi T, Tsukada J, Yoshida Y, Mizobe T, Mouri F, Minami Y, Tanaka Y
- Journal Title
  
  Genes to Cell 10(12)
  
  Pages: 1153-1162
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591018
[Journal Article] Constitutive tyrosine and serine phosphorylation of STAT4 in T-cells transformed with HTLV-I2005
- Author(s)
  Higashi T, Tsukada J, Yoshida Y, Mizobe T, Mouri F, Minami Y, Tanaka Y
- Journal Title
  
  Genes to Cells 10(12)
  
  Pages: 1153-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591018
[Presentation] BDNF produced by leukemia cells attenuates cytokine production in macrophages and induced Foxp3 positive cells through NF-AT, Smad and RhoA.2010
- Author(s)
  Yoshida, Y., Tsukada, J.
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸(神戸国際会議場)
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21591253
[Presentation] BDNF produced by leukemia cells attenuates cytokine production in macrophages and induced Foxp3 positive cells through NF-AT, Smad and RhoA2010
- Author(s)
  Yoshida, Y. and Tsukada, J.
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸ポートアイランド(神戸)
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21591253

1. ETO Sumiya (90010347)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. YOSHIDA Yasuhiro (10309958)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
3. MISAGO Masahiro (30157474)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. TANAKA Yoshiya (30248562)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. MORIMOTO Isao (80145234)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OKADA Kazumasa (30341499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OKADA Yosuke (80333243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAITO Kazuyoshi (30279327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OSADA Yoshio (80282515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. UENO Susumu (00279324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中西司 (00772609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Tsukada Junichi 塚田 順一

塚田 順一 ツカダ ジユンイチ

TSUKADA Junichi 塚田 順一

TSUKADA Jyunichi 塚田 順一

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Growth inhibition of adult T-cell leukemia cells through the Toll-like receptor signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transcriptional activation of the HTLV-I gene in monocytes and macrophages.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Constitutive activation of LIL-Stat in adult T cell leukemia cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction of Human Prointerleukin 1beta Gene by Human T-Cell Leukemia VirusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pentacyclic triterpenoid ursolic acid induces apoptosis with mitochondrial dysfunction in adult T-cell leukemia MT-4 cells to promote surrounding cell growth2022

Author(s)

Journal Title

Data Source

Tsukada Junichi 塚田順一

塚田順一ツカダジユンイチ

TSUKADA Junichi 塚田順一

TSUKADA Jyunichi 塚田順一