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KAMISAKO Toshinori  上硲 俊法

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上硲 俊法  カミサコ トシノリ

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Researcher Number 20233934
Other IDs
Affiliation (Current) 2025: 近畿大学, 大学病院, 教授
Affiliation (based on the past Project Information) *help 2019 – 2023: 近畿大学, 大学病院, 教授
2011 – 2018: 近畿大学, 医学部附属病院, 教授
2003 – 2004: 近畿大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Eating habits / Applied pharmacology / Eating habits, studies on eating habits
Except Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Food science
Keywords
Principal Investigator
diosgenin / ethinylestradiol / MRP3 / MRP2 / ABC transporter / 魚油 / ezetimibe / 脂質代謝 / 糞便中性ステロール / pemafibrate … More / TICE / エゼチミブ / 経小腸コレステロール排泄 / エピジェネティックス / 脂肪酸代謝 / 後成的影響 / 高脂肪食 / 性差 / エピジェネティック / 胆汁酸代謝 / bile acid / bilirubin / cholestasis / 臓器相関 / ABCトランスポーター / 薬物輸送蛋白質 / 胆汁酸 / ビリルビン / 胆汁うっ滞 / ラード / 大豆油 / 脂肪酸組成 / 高コレステロール食 / 脂質組成 / 脂肪酸 / Nrf2 / 酸化ストレス … More
Except Principal Investigator
ABCG5/G8 / エゼチミブ / TICE / コレステロールトランスポーター / 小腸 / 総胆管結紮 / 胆汁鬱滞 / 解毒機構 / 毒性 / 植物ステロール / NPC1L1阻害剤 / ペマフィブラート / 脂質代謝異常 / 鉄過剰蓄積 / 非アルコール性脂肪肝炎 / 食品機能 / 脂肪肝炎 / 酸化ストレス / Nrf2 Less
  • Research Projects

    (7 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (2 People)
  •  Role of TICE in the efficacy and toxicity of plant sterols

    • Principal Investigator
      TANAKA Yuji
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Kindai University
  •  Role of the small intestine in dyslipidemia associated with cholestasis

    • Principal Investigator
      TANAKA Yuji
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Kindai University
  •  Effect of dietary lipid composition on trans-intestinal cholesterol excretionPrincipal Investigator

    • Principal Investigator
      KAMISAKO Toshinori
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Kindai University
  •  Effect of maternal nutrition during pregnancy on lipid metabolism including lipid absorption of offspringPrincipal Investigator

    • Principal Investigator
      KAMISAKO Toshinori
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Eating habits
    • Research Institution
      Kindai University
  •  Role of dietary lipid composition on the crosstalk mechanism between lipid metabolism and oxidative stress regulation.Principal Investigator

    • Principal Investigator
      KAMISAKO Toshinori
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Eating habits, studies on eating habits
    • Research Institution
      Kinki University
  •  Elucidation of the mechanism of onset of steatohepatitis and prevention of pathogenesis with the food ingredients by targeting Nrf2

    • Principal Investigator
      TANAKA Yuji
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Food science
    • Research Institution
      Kinki University
  •  Role of renal and inteslinal ABC transporters during cholestatic liver diseasePrincipal Investigator

    • Principal Investigator
      KAMISAKO Toshinori
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      KINKI UNIVERSITY

All 2024 2023 2020 2019 2018 2016 2014 2013 2012 2004 Other

All Journal Article Presentation

  • [Journal Article] Ezetimibe Markedly Reduces Hepatic Triglycerides and Cholesterol in Rats Fed on Fish Oil by Increasing the Expression of Cholesterol Efflux Transporters2020

    • Author(s)
      Tanaka Yuji、Ikeda Takanori、Ogawa Hiroshi、Kamisako Toshinori
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 374 Issue: 1 Pages: 175-183

    • DOI

      10.1124/jpet.120.265660

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11006, KAKENHI-PROJECT-18K11115
  • [Journal Article] Gender-divergent expression of lipid and bile acid metabolism related genes in adult mice offspring of dams fed a high-fat diet2018

    • Author(s)
      Yuji Tanaka, Takanori Ikeda, Kazuo Yamamoto, Shiori Masuda, Hiroshi Ogawa, Toshinori Kamisako
    • Journal Title

      J Biosciences

      Volume: ー

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K00860
  • [Journal Article] Role of Nrf2 in the alteration of cholesterol and bile acid metabolism-related gene expression by dietary cholesterol in high fat-fed mice2014

    • Author(s)
      Toshinori Kamisako, Yuji Tanaka, Yoshizumi Kishino, Takanori Ikeda, Kazuo Yamamoto, Shiori Masuda, Hiroshi Ogawa
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 54 Issue: 2 Pages: 90-94

    • DOI

      10.3164/jcbn.13-92

    • NAID

      130004879357

    • ISSN
      0912-0009, 1880-5086
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24501010
  • [Journal Article] Ezetimibe increases hepatic iron levels in mice fed a high-fat diet2013

    • Author(s)
      Yoshizumi Kishino ,Yuji Tanaka, Takanori Ikeda, Kazuo Yamamoto, Hiroshi Ogawa, Yoshinori Iwatani, Toshinori Kamisako.
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 345 Issue: 3 Pages: 483-491

    • DOI

      10.1124/jpet.113.203448

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501010
  • [Journal Article] Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2-null mice2012

    • Author(s)
      Tanaka Y, Ikeda T, Yamamoto K, Ogawa H, Kamisako T.
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 27 Issue: 11 Pages: 1711-1717

    • DOI

      10.1111/j.1440-1746.2012.07180.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23580188
  • [Journal Article] Effects of pravastatin and bezafibrate on biliary lipid excretion and hepatic expressions of Abcg5 and Abcg8 in the rats.2004

    • Author(s)
      Toshinori Kamisako, Hiroshi Ogawa
    • Journal Title

      J Gastroenterol Hepatol 19

      Pages: 879-883

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590473
  • [Journal Article] Effects of pravastatin and bezafibrate on biliary lipid excretion and hepatic expressions of Abcg5 and Abcg8 in the rats.2004

    • Author(s)
      Toshinori Kamisako, Hiroshi Ogawa
    • Journal Title

      Journal of Gastroenterology and Hepatology 19

      Pages: 879-883

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590473
  • [Journal Article] Alteration of the expression of ATP binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis.

    • Author(s)
      Toshinori Kamisako, Hiroshi Ogawa
    • Journal Title

      Journal of Gastroenterology and Hepatology (in press)

    • Data Source
      KAKENHI-PROJECT-15590473
  • [Journal Article] Alteration of the expression of ATP binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis.

    • Author(s)
      Toshinori Kamisako, Hiroshi Ogawa
    • Journal Title

      J Gastroenterol Hepatol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590473
  • [Journal Article] Alteration of the expression of ATP binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis.

    • Author(s)
      Toshinori Kamisako, Hiroshi Ogawa
    • Journal Title

      Journal of Gastroenterology and Hepatology (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590473
  • [Presentation] Differential regulation of intestinal sterol efflux transporters and non-biliary cholesterol excretion by dietary oil in bile duct-ligated rats.2024

    • Author(s)
      Tanaka Yuji, Kamisako Toshinori
    • Organizer
      The Society of Toxicology (SOT) 63rd Annual Meeting and ToxExpo
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K11740
  • [Presentation] 油脂成分の体内蓄積が小腸コレステロール排泄機構に及ぼす影響-大豆油と魚油の比較2023

    • Author(s)
      田中裕滋, 上硲俊法
    • Organizer
      第62回日本栄養・食糧学会 近畿支部大会
    • Data Source
      KAKENHI-PROJECT-21K11740
  • [Presentation] Adaptive regulation of bile acid and cholesterol transporters in mouse kidney and intestine during alpha-naphthylisothiocyanate (ANIT)-induced cholestasis2020

    • Author(s)
      Tanaka Yuji、Ikeda Takanori、Ogawa Hiroshi、Kamisako Toshinori
    • Organizer
      The59th Annual Meeting of the Society of toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11006
  • [Presentation] 高脂肪食摂取マウスにおけるワサビ由来6-メチルスルフィニルヘキシルイソチオシアネートのNrf2を介した脂肪改善作用2019

    • Author(s)
      田中裕滋, 池田高紀, 小川 博, 上硲俊法
    • Organizer
      第73回日本栄養・食糧学会大会
    • Data Source
      KAKENHI-PROJECT-18K11006
  • [Presentation] 高脂肪食を摂取した母親から生まれた仔マウスの成長後の胆汁酸関連遺伝子発現の性差2019

    • Author(s)
      田中裕滋, 上硲俊法
    • Organizer
      第55回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-18K11006
  • [Presentation] Increased non-biliary cholesterol excretion during alpha-naphthylisothiocyanate (ANIT)-induced cholestasis in mice2019

    • Author(s)
      Yuji Tanaka, Takanori Ikeda, Hiroshi Ogawa, Toshinori Kamisako
    • Organizer
      The 58th Annual Meeting of the Society of Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11006
  • [Presentation] Ezetimibe markedly reduces hepatic triglycerides and cholesterol in fishoil-fed rats2019

    • Author(s)
      Yuji Tanaka, Takanori Ikeda, Hiroshi Ogawa, Toshinori Kamisako
    • Organizer
      The 70th Annual Meeting of the American Association for theStudy of Liver Diseases
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11006
  • [Presentation] EZETIMIBE MARKEDLY REDUCES HEPATIC TRIGLYCERIDES AND CHOLESTEROL IN FISH OIL-FED RATS2019

    • Author(s)
      Yuji Tanaka, Takanori Ikeda, Kazuo Yamamoto, Hiroshi Ogawa, Toshinori Kamisako.
    • Organizer
      Liver Meeting 2019, The American Association for Study of the Liver Disease (Boston)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11115
  • [Presentation] 魚油含有食摂取がマウスの脂質・胆汁酸代謝に及ぼす影響2018

    • Author(s)
      田中裕滋, 池田高紀, 山本和夫, 小川 博, 上硲俊法
    • Organizer
      第72回日本栄養・食糧学会大会
    • Data Source
      KAKENHI-PROJECT-18K11006
  • [Presentation] Gender-divergent expression of lipid and bile acid metabolism related genes in adult offspring of dams fed a long-term high fat diet before and during pregnancy and lactation.2016

    • Author(s)
      Yuji Tanaka, Takanori Ikeda, Kazuo Yamamoto, Hiroshi Ogawa, Toshinori Kamisako.
    • Organizer
      Liver Meeting 2016, The American Association for Study of the Liver Disease
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2016-11-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K00860
  • [Presentation] ワサビ由来6-メチルスルフィニルヘキシルイソチオシアネートはマウスの高脂肪食誘発性脂肪肝をNrf2依存性に改善する2014

    • Author(s)
      田中裕滋、池田高紀、山本和夫、小川博、上硲俊法
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23580188
  • [Presentation] Wasabi derivative 6-methylsulfinylhexyl isothiocyanate, a potent Nrf2 activator, prevents the fatty liver produced by a high-fat diet but did not attenuate hepatic iron overload in mice2013

    • Author(s)
      Yuji Tanaka, Toshinori Kamisako
    • Organizer
      64th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Washington, D.C., USA
    • Data Source
      KAKENHI-PROJECT-23580188
  • [Presentation] 高脂肪食摂取マウスにおけるエゼチミブ投薬による肝内鉄値増加2013

    • Author(s)
      田中裕滋 岸野好純 池田高紀 山本和夫 小川博 上硲俊法
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24501010
  • [Presentation] 高脂肪食摂取Nrf2欠損マウスにおけるオルチプラズによる肝障害の改善効果2013

    • Author(s)
      田中裕滋 池田高紀 山本和夫 小川博 上硲俊法
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24501010
  • [Presentation] ワサビ由来6-メチルスルフィニルヘキシルイソチオシアネートはマウスの高脂肪食誘発性脂肪肝をNrf2依存性に改善する

    • Author(s)
      田中裕滋 池田高紀 山本和夫 小川博 上硲俊法
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京(ホテルニューオータニ)
    • Year and Date
      2014-05-29 – 2014-05-30
    • Data Source
      KAKENHI-PROJECT-24501010
  • 1.  TANAKA Yuji (00465650)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 19 results
  • 2.  OGAWA Hiroshi (00133546)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results

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