KUMAGAI Naoki 熊谷直樹

… Alternative Names

熊谷真樹クマガイナオキ

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Researcher Number	20234510
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2006: Yamaguchi University, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授 2001 – 2005: Yamaguchi University, School of Medicine, Assistant professor, 医学部, 助教授 1998 – 2000: 山口大学, 医学部・附属病院, 講師 1998: Yamaguchi University Hospital, Assistant Professor, 医学部附属病院, 講師 1996 – 1997: 山口大学, 医学部・附属病院, 助手 1995: 横浜市立大学, 医学部・眼科, 講師 1993 – 1995: 横浜市立大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Ophthalmology / Ophthalmology Except Principal Investigator Ophthalmology
Keywords	Principal Investigator アレルギー性結膜炎 / スーパー抗原 / コラーゲン分解 / 角膜 / サイトカイン / IL-4 / IL-13 / LPS / IL-8 / MCP-1 … More / ICAM-1 / TLR-4 / CD14 / LBP / マウス / 肥満細胸 / サブスタンスP / 動物モデル / 肥満細胞 / 細菌感染 / ぶどう球菌 / 緑膿菌 / 角膜実質細胞 / エオタキシン / TARC / TNF-α / 角膜上皮細胞 / Corneal fibroblasts / eotaxin / thymus and activation-regulated chemokines / TNG-α / 角膜線維芽細胞 / corneal fibroblasts / ケモカイン / 接着分子 / allergic conjunctiva / cornea / chemokine / adhesion molecule / cytokine … More Except Principal Investigator substance P / IGF-1 / 分子生物学 / ベーチェット病 / サルコイドーシス / HLA / 神経麻痺性角膜症 / 角膜上皮創傷治癒 / protein kinase C / コラーゲン分解 / 炎症性眼疾患 / 疾患感受性遺伝子 / アレルギー性眼疾患 / アデノウイルス結膜炎 / クラミジア結膜炎 / ぶどう膜炎 / 原田病 / 免疫遺伝学 / 難治性ぶどう膜炎 / 分子遺伝学 / 分子免疫学 / 実験的自己免疫性網膜ぶどう膜炎 / UVEITIS / BEHCET'S DISEASE / VOGT-KOYANAGI-HARADA'S DISEASE / MOLECULAR BIOLOGY / IMMUNOGENETICS / 角膜上皮 / 創傷治癒 / 細胞内シグナル / インテグリン / 細胞接着 / フィブロネクチン / 遷延性角膜上皮欠損 / PKC / focal adhesion kinase / corneal epithelium / neurotrophic keratopathy / wound healing / intracellular signal / integrin / cell adhesion / substnce P / 細胞内信号伝達系 / IL-1受容体アンタゴニスト / corneal epithelial wound healing / neuro-paralytic keratopathy / intracellular signal transduction / collagenolysis / IL-1 receptor antagonist / 角膜 / 上皮細胞 / 線維芽細胞 / 増殖 / リン酸化 / 酸素 / 上皮-実質複合体 / 培養細胞 / 角膜上皮細胞 / バリアー機能 / サイトカイン / 密着結合 / 角膜実質細胞 / 3次元ゲル内培養 / 細胞外マトリックス / 細胞増殖 / apoptosis / 成長因子 / アポトーシス / Akt / Rho / cornea / epithelial cell / fibroblasts / cellular proliferation / phosphorylation / oxygen / epithelium-stroma complex / cultured cells Less

Role of corneal-conjunctival interaction on the pathogenesis of allergic conjunctivitisPrincipal Investigator
- Principal Investigator
  
  KUMAGAI Naoki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Yamaguchi University
Characterization of the regulation of corneal epithelial and stromal functions in order to further the development of an artificial cornea
- Principal Investigator
  
  NISHIDA Teruo
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Yamaguchi University
Research on the innate immune system of the corneaPrincipal Investigator
- Principal Investigator
  
  KUMAGAI Naoki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Yamaguchi University
Reciprocal interaction between epithelial cells and keratocytes in neurotrophic keratopathy
- Principal Investigator
  
  NISHIDA Teruo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Yamaguchi University
Role for corneal fibroblasts in the pathogenesis of allergic conjunctival diseasesPrincipal Investigator
- Principal Investigator
  
  KUMAGAI Naoki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Yamaguchi University
緑膿菌性角膜潰瘍における病原体と生体の相互作用Principal Investigator
- Principal Investigator
  
  熊谷直樹
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Yamaguchi University
Investigation on the pathology of neurotrophic keratopathy and development of new drugs
- Principal Investigator
  
  NISHIDA Teruo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Yamaguchi University
フリクテン性角結膜炎におけるスーパー抗原の関与Principal Investigator
- Principal Investigator
  
  熊谷直樹
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Yamaguchi University
炎症性眼疾患の分子生物学的研究
- Principal Investigator
  
  OHNO Shigeaki
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Yokohama City University
重症アレルギー性結膜炎におけるスーパー抗原の関与Principal Investigator
- Principal Investigator
  
  熊谷直樹
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Yokohama City University
実験的慢性アレルギー性結膜炎における局所免疫Principal Investigator
- Principal Investigator
  
  熊谷直樹
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Yokohama City University
実験的アレルギー性粘膜炎における局所免疫Principal Investigator
- Principal Investigator
  
  熊谷真樹
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Yokohama City University
MOLECULAR IMMUNOLOGICAL STUDIES ON ITRACTABLE UVEITIS FREQUENTLY SEEN IN JAPAN.
- Principal Investigator
  
  OHNO Shigeaki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Yokohama City University

All 2006 2005 2004 2003 2002

All Journal Article

[Journal Article] Vernal keratoconjunctivitis2006
- Author(s)
  Naoki Kumagai
- Journal Title
  
  Japanese Journal of Clinical Ophthalmology 60・2
  
  Pages: 111-115
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Role of structural cells of the cornea and conjunctiva in the pathogensis of vernal keratoconjunctivitis.2006
- Author(s)
  Naoki Kumagai.
- Journal Title
  
  Progress in Rentinal and Eye Research 25・2
  
  Pages: 165-187
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Role of structural cells of the cornea and conjunctiva in the pathogenesis of vernal keratoconjunctivitis.2006
- Author(s)
  Naoki Kumagai et al.
- Journal Title
  
  Progress in Retinal and Eye Research 25-2
  
  Pages: 165-187
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591837
[Journal Article] Role of structural cells of the cornea and conjunctiva in the pathogenesis of vernal keratoconjunctivitis.2006
- Author(s)
  Naoki Kumagai et al.
- Journal Title
  
  Progress in Retinal and Eye Research 25・2
  
  Pages: 165-187
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591837
[Journal Article] 春季カタル2006
- Author(s)
  熊谷直樹
- Journal Title
  
  臨床眼科 60・2
  
  Pages: 111-115
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Role of structural cells of the cornea and conjunctiva in the pathogensis of vernal keratoconjunctivitis.2006
- Author(s)
  Naoki Kumagai.
- Journal Title
  
  Progress in Rentinal and Eye Research. 25・2
  
  Pages: 165-187
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Role of structural cells of the cornea and conjunctiva in the pathogenesis of vernal keratocon junctivitis2006
- Author(s)
  Naoki Kumagai et al.
- Journal Title
  
  Progress in Retinal and Eye Research 25・2
  
  Pages: 165-187
- Data Source
  KAKENHI-PROJECT-17591837
[Journal Article] Lipopolysaccharide-induced expression of intercellular adhesion molecule-1 and chemokines in cultured human corneal fibroblasts.2005
- Author(s)
  Naoki Kumagai.
- Journal Title
  
  Invest Ophthalmol Vis Sci. 46
  
  Pages: 114-120
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Lipopolysaccharide-induced expression of intercellular adhesion molecule-1 and chemokines in cultured human corneal fibroblasts.2005
- Author(s)
  Naoki Kumagai.
- Journal Title
  
  Invest Ophthalmol Vis Sci 46
  
  Pages: 114-120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] アレルギー性結膜炎の診断と治療2005
- Author(s)
  熊谷直樹
- Journal Title
  
  眼科 48
  
  Pages: 1963-1971
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Lipopolysaccharide-induced expression of intercellular adhesion molecule-1 and chemokines in cultured human corneal fibroblasts.2005
- Author(s)
  Kumagai N et al.
- Journal Title
  
  Invest Ophthalmol Vis Sci. 46・1
  
  Pages: 114-120
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Treatment of Corneal Lesions in Individuals with Vernal Keratoconjunctivitis.2005
- Author(s)
  Naoki Kumagai.
- Journal Title
  
  Allergol Int. 54
  
  Pages: 51-59
- NAID
  10014468619
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Treatment of Corneal Lesions in Individuals with Vernal Keratoconjunctivitis.2005
- Author(s)
  Naoki Kumagai.
- Journal Title
  
  Allergol Int 54
  
  Pages: 51-59
- NAID
  10014468619
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Diagnosis and treatment of allergic conjunctivitis2005
- Author(s)
  Naoki Kumagai
- Journal Title
  
  GANKA 47
  
  Pages: 1963-1971
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] 花粉症における結膜の増殖性変化と化学伝達物質2004
- Author(s)
  熊谷直樹
- Journal Title
  
  臨床医 30・2
  
  Pages: 203-206
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Vernal keratoconjunctivitis2004
- Author(s)
  Naoki Kumagai
- Journal Title
  
  Medical ASAHI 33
  
  Pages: 26-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] 特集「花粉症治療UPDATE : 鼻と眼の症状を改善する薬物療法」 : 春季カタル角膜病変を生じる重症型アレルギー眼疾患2004
- Author(s)
  熊谷直樹
- Journal Title
  
  メディカル朝日 33
  
  Pages: 26-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Conjunctival proliferative lesion and chemical mediators in ocula allergic disease2004
- Author(s)
  Naoki Kumagai
- Journal Title
  
  Rinsyoui 30・2
  
  Pages: 203-206
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Synergistic effect of TNF-α and either IL-4 or IL-13 on VCAM-1 expression by cultured human corneal fibrobalsts.2003
- Author(s)
  Naoki Kumagai.
- Journal Title
  
  Cornea 22
  
  Pages: 557-561
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Synergistic effect of TNF-α and either IL-4 of IL-13 on VCAM-1 expression by cultured human corneal fibrobalsts.2003
- Author(s)
  Naoki Kumagai.
- Journal Title
  
  Cornea. 22
  
  Pages: 557-561
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Expression of functional ICAM-l on cultured human keratocytes induced by tumor neurosis factor-α.2003
- Author(s)
  Naoki Kumagai.
- Journal Title
  
  Jpn J Ophthalmol. 47
  
  Pages: 134-141
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Expression of functional ICAM-1 on cultured human keratocytes induced by tumor neurosis factor-α.2003
- Author(s)
  Naoki Kumagai.
- Journal Title
  
  Jpn J Ophthalmol 47
  
  Pages: 134-141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis.2002
- Author(s)
  Naoki Kumagai.
- Journal Title
  
  J Allergy Clin Immunol 110
  
  Pages: 489-491
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207070
[Journal Article] Active matrix metalloproteinases in the tear fluid of individuals with vemal keratoconjunctivitis.2002
- Author(s)
  Naoki Kumagai.
- Journal Title
  
  J Allergy Clin Immunol. 110
  
  Pages: 489-491
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207070

1. NISHIDA Teruo (80036475)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. FUKUDA Ken (70335751)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. OHNO Shigeaki (50002382)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAKAMURA Satoshi (00237398)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SEKI Keisuke (50318820)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. UCHIO Eiichi (70232840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TANAKA Toshiro (30236608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ENOKI Miho (00274176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. CHIKAMA Tai-ichiro (00263765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 伊藤典彦 (80264654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 杉田美由紀 (90235888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 磯部裕 (30193402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松本覚

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUMAGAI Naoki 熊谷 直樹

熊谷 真樹 クマガイ ナオキ

Research Projects

Research Products

Co-Researchers

Role of corneal-conjunctival interaction on the pathogenesis of allergic conjunctivitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of the regulation of corneal epithelial and stromal functions in order to further the development of an artificial cornea

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on the innate immune system of the corneaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reciprocal interaction between epithelial cells and keratocytes in neurotrophic keratopathy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role for corneal fibroblasts in the pathogenesis of allergic conjunctival diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

緑膿菌性角膜潰瘍における病原体と生体の相互作用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation on the pathology of neurotrophic keratopathy and development of new drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

フリクテン性角結膜炎におけるスーパー抗原の関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

炎症性眼疾患の分子生物学的研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

重症アレルギー性結膜炎におけるスーパー抗原の関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

実験的慢性アレルギー性結膜炎における局所免疫Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

実験的アレルギー性粘膜炎における局所免疫Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MOLECULAR IMMUNOLOGICAL STUDIES ON ITRACTABLE UVEITIS FREQUENTLY SEEN IN JAPAN.

Principal Investigator

Project Period (FY)

KUMAGAI Naoki 熊谷直樹

熊谷真樹クマガイナオキ