ONO Shinichi 小野真一

Researcher Number	20246862
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2015: 日本大学, 薬学部, 教授 2009 – 2010: Nihon University, 薬学部, 准教授
Review Section/Research Field	Principal Investigator Laboratory medicine / Neurology Except Principal Investigator Social dentistry
Keywords	Principal Investigator バイオマーカー / 筋萎縮性側索硬化症 / テトラチオモリブデン酸 / 銅イオンキレート / 変異SOD1 / Ammonium tetrathiomolybdate / 銅イオン / 銅 / メタロチオネイン / 蛋白質 / 薬学 / 脳神経疾患 … More Except Principal Investigator … More 薬力学 / 摂食・嚥下機能 / 嚥下潜時時間 / 脳梗塞 / 嚥下内視鏡 / 嚥下障害 / 血中濃度 / プラミペキソール / パーキンソン治療薬 / 舌骨最大拳上量 / 2次元動画解析ソフト / 嚥下動態 / 誤嚥 / 嚥下運動パターン / パーキンソン病 / 嚥下造影検査 / 嚥下機能 / 薬物動態 Less

pharmacokinetic and pharmacodynamics effect of neuropsychiatric disease to maintain the swallow function
- Principal Investigator
  
  Kikutani Takeshi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  The Nippon Dental University
An attempt to elucidate a biomarker for the diagnosis of amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  ONO Shinichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Nihon University
細胞内の銅イオン制御による筋萎縮性側索硬化症の新規治療Principal Investigator
- Principal Investigator
  
  小野真一
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Nihon University

All 2013 2012 2011 2010 2009

All Journal Article Presentation Book Patent

[Book] Brain Diseases and Metalloproteins.2012
- Author(s)
  Ono S, Tokuda E, Okawa E, Watanabe S
- Publisher
  Pan Stanford Publishing, Singapore
- Data Source
  KAKENHI-PROJECT-23659309
[Book] 病気と薬パーフェクトガイド (薬局増刊）の筋脱力の項2012
- Author(s)
  小野真一、渡邊俊輔
- Total Pages
  3
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-23659309
[Book] Brain Diseases and Metalloproteins.2012
- Author(s)
  Ono S, Tokuda E, Okawa E, Watanabe S
- Total Pages
  39
- Publisher
  Pan Stanford Publishing
- Data Source
  KAKENHI-PROJECT-23659309
[Book] An attempt to treat amyotrophic lateral sclerosis by intracellular copper modification using anmmonium tetrathiomolybdate and/or metallothionein.Fund amentals and perspective.2011
- Author(s)
  Ono S., Tokuda E, Okawa E, Watanabe S
- Publisher
  Pan Stanford Publishing, Singapore(in press)
- Data Source
  KAKENHI-PROJECT-21659222
[Book] 病気と薬パーフェクトBOOK 2011 (薬局増刊号)2011
- Author(s)
  小野真二、徳田栄一
- Total Pages
  4
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-21659222
[Journal Article] Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities.2013
- Author(s)
  Tokuda E, Okawa E, Watanabe S, Ono S, Marklund SL
- Journal Title
  
  Neurobiology of Disease
  
  Volume: in press Pages: 308-319
- DOI
  10.1016/j.nbd.2013.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659309
[Journal Article] Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities.2013
- Author(s)
  Tokuda E, Okawa E, Watanabe S, Ono S, Marklund S
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 54 Pages: 308-319
- Data Source
  KAKENHI-PROJECT-23659309
[Journal Article] A possible novel pharmacological therapy for Parkinson disease using the pleiotropic property of selegiline.2013
- Author(s)
  Ono S, Sone R, Tokuda E.
- Journal Title
  
  Journal of Alzheimer's disease and Parkinsonism.
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23659309
[Journal Article] Dysregulation of intracellular copper homeostasis is common for dismutase active and inactive form of SOD1 mutants (abst).2011
- Author(s)
  Tokuda E, Okawa E, Watanabe S, Ono S
- Journal Title
  
  Amyotrophic Lateral Sclerosis
  
  Volume: 12 (suppl 1) Pages: 120-121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659309
[Journal Article] Administration of recombinant metallothionein-I starting at onset prolongs survival in a mouse model of mutant SOD1-linked familial ALS.2010
- Author(s)
  Tokuda E, Ono S
- Journal Title
  
  Amyotrophic Lateral Sclerosis
  
  Volume: 41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659222
[Journal Article] Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis2009
- Author(s)
  Tokuda E, Okawa E, Ono SI
- Journal Title
  
  Journal of Neurochemistry 111
  
  Pages: 181-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659222
[Patent] 筋萎縮性側策硬化症治療薬2012
- Inventor(s)
  小野真一、徳田栄一
- Industrial Property Rights Holder
  学校法人日本大学
- Acquisition Date
  2012-10-05
- Data Source
  KAKENHI-PROJECT-23659309
[Presentation] Psychoactive agent may affect swallowing function in elderly people.2011
- Author(s)
  Tejima C, Tamura F, Kikutani T, Ono S, Matsumoto Y
- Organizer
  The59th Annual Meeting of Japanese Association for Dental Research
- Place of Presentation
  広島国際会議場(広島)
- Data Source
  KAKENHI-PROJECT-23593108
[Presentation] Psychoactive agents may affect swallowing function in elderly people.2011
- Author(s)
  Tejima C, Kikutani T, Tamura F, Matumoto Y, Ono S
- Organizer
  59th Annual Meeting of Japanese Association for Dental Research.
- Place of Presentation
  Hiroshima, Japan
- Data Source
  KAKENHI-PROJECT-23659309
[Presentation] Dysregulation of intracellular copper homeostasis is common for dismutase active and inactive form of SOD1 mutants.2011
- Author(s)
  Tokuda E、Okawa E, Watanabe S, Ono S, Marklund SL
- Organizer
  22nd International Conference on ALS/MND
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-23659309
[Presentation] Dysregulation of intracellular copper trafficking in common for active and inactive form of SOD1 mutants.2011
- Author(s)
  Tokuda E, Ono S, Marklund SL
- Organizer
  9th Meeting of the European Network for the Cure of Amyotrophic Lateral Sclerosis.
- Place of Presentation
  Hannover, Germany
- Data Source
  KAKENHI-PROJECT-23659309
[Presentation] Dysregulation of intracellular copper homeostasis is common for dismutase active and inactive form of SOD1 mutants2011
- Author(s)
  Tokuda E、Okawa E, Watanabe S, Ono S, Marklund SL
- Organizer
  The 22nd International Conference on ALS/MND
- Place of Presentation
  Sydney, Australia
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23659309
[Presentation] Dysregulation of intracellular copper trafficking in common for active and inactive form of SOD1 mutants2011
- Author(s)
  Tokuda E, Ono S, Marklund SL
- Organizer
  9th Meeting of the European Network for the Cure of Amyotrophic Lateral Sclerosis.
- Place of Presentation
  Hannover, Germany
- Data Source
  KAKENHI-PROJECT-23659309
[Presentation] Cu結合たん白質メタロチオネイン-Iは進行期のALSモデルマウスに奏効する2010
- Author(s)
  小野真一,徳田栄一
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21659222
[Presentation] 神経変性疾患に有効なフラクションと化合物のスクリーニングとライブラリー化2010
- Author(s)
  小野真一, 草間國子, 渡邊雅紀
- Organizer
  平成19年度選定文部科学省学術フロンティア推進事業研究プロジェクト「天然物フラクション・化合物ライブラリーの構築―細胞傷害活性と保護性に基づく難病の治療薬開発を目指して―」平成21年度研究報告会
- Place of Presentation
  船橋(千葉)
- Year and Date
  2010-02-26
- Data Source
  KAKENHI-PROJECT-21659222
[Presentation] Administration of recombinant metallothionein-I prolongs survival in a mouse model of mutant SODI-linked familial ALS.2010
- Author(s)
  Tokuda E, Ono S
- Organizer
  The 21^<st> International Conference on ALSIMND
- Place of Presentation
  Orland, USA
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21659222
[Presentation] Metallothionein 誘導は筋萎縮性側索硬化症マウスの運動ニューロン死を抑制し、ALS様症状を改善する2009
- Author(s)
  徳田栄一, 渡邊俊輔, 大川枝里子, 鈴木孝, 内倉和雄, 小野真一
- Organizer
  第27回日本神経治療学会総会
- Place of Presentation
  熊本
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21659222
[Presentation] 外因性 metallothionein-Iは筋萎縮性側索硬化症マウスのALS様症状に奏功する2009
- Author(s)
  徳田栄一, 鈴木孝, 小野真一
- Organizer
  第20回日本大学薬学部学術講演会
- Place of Presentation
  船橋(千葉)
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-21659222
[Presentation] メタロチオネインによる筋萎縮性側索硬化症の治療. その理論的背景と展望2009
- Author(s)
  小野真一, 徳田栄一, 渡邊俊輔, 大川枝里子
- Organizer
  第7回メタロチオネインおよびメタルバイオサイエンス研究会
- Place of Presentation
  東京
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-21659222
[Presentation] 外因性Mt-Iは進行期の筋萎縮性側索硬化症マウスにさえ奏効する2009
- Author(s)
  徳田栄一, 小野真一
- Organizer
  第7回メタロチオネインおよびメタルバイオサイエンス研究会
- Place of Presentation
  東京
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-21659222
[Presentation] 細胞内銅イオン制御による筋萎縮性側索硬化症治療の試み2009
- Author(s)
  小野真一
- Organizer
  平成19年度文部科学省選定日本大学薬学部学術フロンティア推進事業研究プロジェクトシンポジウム「天然物フラクション。化合物ライブラリーの構築 -細胞傷害性と保護性に基づく難病の治療薬開発を目指して-」
- Place of Presentation
  東京
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-21659222
[Presentation] Overexpression of glial metallothionein slows disease progression in a mouse model of mutant SOD1-linked familial ALS2009
- Author(s)
  徳田栄一, 小野真一
- Organizer
  20th International Symposium on ALS/MND.
- Place of Presentation
  Berlin
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21659222

1. Kikutani Takeshi (20214744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. Matsumoto Nobuaki (10199896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. SUZUKI Utaka (10287625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ONO Shinichi 小野 真一

Research Projects

Research Products

Co-Researchers

pharmacokinetic and pharmacodynamics effect of neuropsychiatric disease to maintain the swallow function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An attempt to elucidate a biomarker for the diagnosis of amyotrophic lateral sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞内の銅イオン制御による筋萎縮性側索硬化症の新規治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Brain Diseases and Metalloproteins.2012

Author(s)

Publisher

Data Source

[Book] 病気と薬パーフェクトガイド (薬局 増刊） の筋脱力の項2012

Author(s)

Total Pages

Publisher

Data Source

[Book] Brain Diseases and Metalloproteins.2012

Author(s)

Total Pages

Publisher

Data Source

[Book] An attempt to treat amyotrophic lateral sclerosis by intracellular copper modification using anmmonium tetrathiomolybdate and/or metallothionein.Fund amentals and perspective.2011

Author(s)

Publisher

Data Source

[Book] 病気と薬パーフェクトBOOK 2011 (薬局 増刊号)2011

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities.2013

Author(s)

Journal Title

Data Source

[Journal Article] A possible novel pharmacological therapy for Parkinson disease using the pleiotropic property of selegiline.2013

Author(s)

Journal Title

Data Source

[Journal Article] Dysregulation of intracellular copper homeostasis is common for dismutase active and inactive form of SOD1 mutants (abst).2011

Author(s)

Journal Title

Data Source

[Journal Article] Administration of recombinant metallothionein-I starting at onset prolongs survival in a mouse model of mutant SOD1-linked familial ALS.2010

Author(s)

Journal Title

Data Source

[Journal Article] Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis2009

Author(s)

Journal Title

Data Source

[Patent] 筋萎縮性側策硬化症治療薬2012

Inventor(s)

Industrial Property Rights Holder

Acquisition Date

Data Source

[Presentation] Psychoactive agent may affect swallowing function in elderly people.2011

Author(s)

Organizer

Place of Presentation

Data Source

ONO Shinichi 小野真一

[Book] 病気と薬パーフェクトガイド (薬局増刊）の筋脱力の項2012

[Book] 病気と薬パーフェクトBOOK 2011 (薬局増刊号)2011