Nukaga Michiyoshi 額賀路嘉

… Alternative Names

NUKAGA Michiyoshi 額賀路嘉

額賀路嘉ヌカガミチヨシ

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Researcher Number	20251150
Affiliation (Current)	2025: 城西国際大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 城西国際大学, 薬学部, 教授 2016: 城西国際大学, 薬学部, 教授 2010 – 2016: 城西国際大学, 薬学部, 准教授 2006: Josai International University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 教授 2005 – 2006: 城西国際大学, 薬学部, 助教授 1998: 千葉大, 薬学部, 助手 1996: 千葉大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 49050:Bacteriology-related / Drug development chemistry / Bacteriology (including mycology) / Bacteriology (including Mycology)
Keywords	Principal Investigator X線結晶解析 / 抗生物質 / 薬剤耐性 / β-ラクタマーゼ / 構造生物学 / 蛋白質 / 感染症 / 分子動力学計算 / タンパク質 / 酵素 … More / 細胞壁合成阻害剤 / PBP / MRSA / Ｘ線結晶解析 / 抗生物質耐性 / ARM / 第五世代セフェム / カルバペネム / バークホルデリア・セパシア細菌群 / メチシリン耐性黄色ブドウ球菌 / カルバペネマーゼ / 抗菌薬 / 耐性菌 / ペニシリン結合タンパク質 / X-ray Crystallography / Protein / Enzyme / Antibiotics / Infection Disease / β-ラクタム剤 / オキシイミノ系β-ラクタム剤 / ループ構造 / 部位特異変異導入 / 基質特異性 Less

X-ray crystallographic analysis of penicillin-recognizing enzyme for the search of non-covalent inhibitorsPrincipal Investigator
- Principal Investigator
  
  NUKAGA Michiyoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Josai International University
Structure basis of reaction mechanism of beta-lactamases and new inhibitor searchPrincipal Investigator
- Principal Investigator
  
  Nukaga Michiyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Josai International University
Ultra high resolution Xray crystallographic study for antibiotic mechanisms of action and resistancePrincipal Investigator
- Principal Investigator
  
  NUKAGA Michiyoshi
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Josai International University
X-ray Crystallographic Study of Antibiotics resistant ProteinsPrincipal Investigator
- Principal Investigator
  
  NUKAGA Michiyoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Josai International University
基質特異性拡張型β−ラクタマーゼの活性中心構造とその分子進化Principal Investigator
- Principal Investigator
  
  額賀路嘉
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
クラスCβ-ラクタマーゼHelix8,9間ループの基質特異性に与える影響Principal Investigator
- Principal Investigator
  
  額賀路嘉
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University

All 2024 2021 2020 2017 2016 2015 2013 2012 2011 2010 2006 2005

All Journal Article Presentation

[Journal Article] Development of Inhibitory Compounds for Metallo-beta-lactamase through Computational Design and Crystallographic Analysis2024
- Author(s)
  Kamo Taichi、Kuroda Keiichi、Nimura Saki、Guo Yan、Kondo Shota、Nukaga Michiyoshi、Hoshino Tyuji
- Journal Title
  
  Biochemistry
  
  Volume: - Issue: 10 Pages: 1278-1286
- DOI
  10.1021/acs.biochem.4c00069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07484
[Journal Article] Assessing the Potency of β-Lactamase Inhibitors with Diverse Inactivation Mechanisms against the PenA1 Carbapenemase from Burkholderia multivorans.2021
- Author(s)
  Nukaga M, Yoon MJ, Taracilia MA, Hoshino T, Becka SA, Zeiser ET, Johnson JR, Papp-Wallace KM
- Journal Title
  
  ACS Infect Dis.
  
  Volume: 7 Issue: 4 Pages: 826-837
- DOI
  10.1021/acsinfecdis.0c00682
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07484
[Journal Article] Identification of the Inhibitory Compounds for Metallo-β-lactamases and Structural Analysis of the Binding Modes2021
- Author(s)
  Kamo T, Kuroda K, Kondo S, Hayashi U, Fudo S, Yoneda T, Takaya A, Nukaga M, Hoshino T.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 69 Issue: 12 Pages: 1179-1183
- DOI
  10.1248/cpb.c21-00611
- NAID
  130008123292
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2021-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07484, KAKENHI-PROJECT-21K07050
[Journal Article] Overcoming an Extremely Drug Resistant (XDR) Pathogen: Avibactam Restores Susceptibility to Ceftazidime for Burkholderia cepacia Complex Isolates from Cystic Fibrosis Patients.2017
- Author(s)
  Papp-Wallace KM, Becka SA, Zeiser ET, Ohuchi N, Mojica MF, Gatta JA, Falleni M, Tosi D, Borghi E, Winkler ML, Wilson BM, LiPuma JJ, Nukaga M, Bonomo RA.
- Journal Title
  
  ACS Infect Dis.
  
  Volume: 印刷中 Issue: 7 Pages: 502-511
- DOI
  10.1021/acsinfecdis.7b00020
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460534
[Journal Article] クラスCβ-ラクタマーゼー構造、反応機構、進化2015
- Author(s)
  額賀路嘉
- Journal Title
  
  臨床と微生物
  
  Volume: 42 Pages: 35-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460534
[Journal Article] In- sights intoβ-lactamases from Burkholderia species, two phylogenetically related yet dis- tinct resistance determinants2013
- Author(s)
  Papp-Wallace KM, Taracila MA, Gatta JA, Ohuchi N., Bonomo R. A., Nukaga M
- Journal Title
  
  Journal of Bi- ological Chemistry
  
  Volume: Vol.288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590401
[Journal Article] β-ラクタマーゼの構造から考える耐性獲得機構、オキシイミノ系およびカルバペネム系β-ラクタム剤を中心に2013
- Author(s)
  額賀路嘉
- Journal Title
  
  日本化学療法学会雑誌
  
  Volume: Vol.61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590401
[Journal Article] Insights into β-lactamases from Burkholderia species, two phylogenetically related yet distinct resistance determinants.2013
- Author(s)
  Krisztina M. Papp-Wallace, Magdalena A. Taracila, Julian A. Gatta, Nozomi Ohuchi, Robert A. Bonomo, and Michiyoshi Nukaga
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 288 Issue: 26 Pages: 19090-19102
- DOI
  10.1074/jbc.m113.458315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590401
[Journal Article] β-ラクタマーゼの構造から考える耐性獲得機構2013
- Author(s)
  額賀路嘉
- Journal Title
  
  化学療法学会雑誌
  
  Volume: 61 Pages: 479-491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590401
[Journal Article] 14員環マクロライド抗生物質が核質タンパク性因子の細胞内動態に及ぼす影響2012
- Author(s)
  懸川友人、古荘論美、額賀路嘉、小澤実香、小嶋文良、吉田ルシア幸子、大室弘美
- Journal Title
  
  The Japanese Journal of Antibiotic
  
  Volume: Vol.65 Pages: 116-120
- Data Source
  KAKENHI-PROJECT-22590401
[Journal Article] Thrombin-stimulated prolifera- tion is mediated by endothelin-1 in cultured rat gingival fibroblasts2010
- Author(s)
  Ohuchi N, Hayashi K, Iwamoto K, Koike K, Kizawa Y, Nukaga M, Kakegawa T, Mu- rakami H
- Journal Title
  
  Fundam. Clin. Phar- macol
  
  Volume: Vol.16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590401
[Journal Article] SHV-1β-ラクタマーゼ・メロペネム複合体のX線結晶解析2006
- Author(s)
  額賀路嘉
- Journal Title
  
  第79回日本細菌学会総会 (学会発表)(金沢)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] Inhibition of the Class A Beta-Lactamases by Carbapenems : Crystallographic Observation of Two Conformations of Meropenem in SHV-12006
- Author(s)
  M.Nukaga, C.R.Bethel, J.M.Thomson, J.R.Knox, R.A.Bonomo
- Journal Title
  
  46^<th> Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, California, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] X-ray Crystallographic study of SHV-1 : meropenem complex.2006
- Author(s)
  M.Nukaga
- Journal Title
  
  79^<th> Annual Meeting of Japanese Society for Microbiology. Kanazawa, JAPAN
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] SHV-1β-ラクタマーゼ・メロペネム複合体のX線結晶解析(学会抄録)2006
- Author(s)
  額賀路嘉
- Journal Title
  
  日本細菌学雑誌 61・1
  
  Pages: 114-114
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] Inhibition of the Class A Beta-Lactamases by Carbapenems : Crystallographic Observation of Two Conformations of Meropenem in SHV-12006
- Author(s)
  M.Nukaga, C.R.Bethel, J.M.Thomson, J.R.Knox, R.A.Bonomo
- Journal Title
  
  46^<th> Interscience Conference of Antimicrobial Agents and Chemotherapy Abstract Book
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] Inhibition of the Class A Beta-Lactamases by Carbapenems : Crystallogra phic Observation of Two Conformations of Meropenem in SHV-12006
- Author(s)
  M.Nukaga, C.R.Bethel, J.M.Thomson, J.R.Knox, R.A.Bonomo
- Journal Title
  
  46^<th> Interscience Conference on Antimicrobial Agents and Chemotherapy (学会発表)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] Inhibition of class D beta-lactamases by diaroyl phosphates2005
- Author(s)
  Majumdar S, Adediran SA, Nukaga M, Pratt RF
- Journal Title
  
  Biochemistry 44・49
  
  Pages: 16121-16129
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] The D-methyl group in beta-lactamase evolution : evidence from the Y221G and GC1 mutants of the class C beta-lactamase of Enterobacter cloacae P99.2005
- Author(s)
  Adediran SA, Zhang Z, Nukaga M, Palzkill T, Pratt RF
- Journal Title
  
  Biochemistry 44
  
  Pages: 7543-7552
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] Inhibition of class D beta-lactamases by acyl phosphates and phosphonates.2005
- Author(s)
  Adediran SA, Nukaga M, Baurin S, Frere JM, Pratt RF.
- Journal Title
  
  Antimicrob Agents Chemother. 49・10
  
  Pages: 4410-4412
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] Inhibition of class D beta-lactamases by diaroyl phosphates2005
- Author(s)
  Adediran SA, Nukaga M, Baurin S, Frere JM, Pratt RF
- Journal Title
  
  Antimicrob Agents Chemother. 44
  
  Pages: 4410-4412
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] Inhibition of class D beta-lactamases by acyl phosphates and phosphonates.2005
- Author(s)
  Adediran SA, Nukaga M, Baurin S, Frere jM, Pratt RF.
- Journal Title
  
  Antimicrob Agents Chemother. Vol.49
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] The D-methyl group in beta-lactamase evolution : evidence from the Y221G and GC1 mutants of the class C beta-lactamase of Enterobacter cloacae P99.2005
- Author(s)
  Adediran SA, Zhang Z, Nukaga M, Palzkill T, Pratt RF.
- Journal Title
  
  Biochemistry Vol.44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] Inhibition of class D beta-lactamases by diaroyl phosphates2005
- Author(s)
  Majumdar S, Adediran SA, Nukaga M, Pratt RF
- Journal Title
  
  Biochemistry 44
  
  Pages: 16121-16129
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] The D-methyl group in beta-lactamase evolution : evidence from the Y221G and GC1 mutants of the class C beta-lactamase of Enterobacter cloacae P99.2005
- Author(s)
  Adediran SA, Zhang Z, Nukaga M, Palzkill T, Pratt RF.
- Journal Title
  
  Biochemistry 44・20
  
  Pages: 7543-7552
- Data Source
  KAKENHI-PROJECT-17590090
[Journal Article] Inhibition of class D beta-lactamases by diaroyl phosphates2005
- Author(s)
  Majumdar S, Adediran SA, Nukaga M, Pratt RF
- Journal Title
  
  Biochemistry Vol.44
  
  Pages: 16121-16129
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590090
[Presentation] Burkholderia multivorans由来の薬剤耐性因子PenRのX線結晶構造解析2024
- Author(s)
  渋谷明日香、坂本翔、星野忠次、Maria F Mojica、額賀路嘉
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-20K07484
[Presentation] Characterizing the resistance mechanisms present in an unusually, highly multi-drug resistant isolate of Burkholderia multivorans（ASM Microbe online, ePoster）2020
- Author(s)
  M. Nukaga, S. A. Becka, E. T. Zeiser, J. J. LiPuma, K. M. Papp-Wallace
- Organizer
  5th ASM Microbe Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07484
[Presentation] “Size matters”: Probing the Mechanisms of Inactivation of Class C beta-lactamases with Avibactam (AVI)2016
- Author(s)
  M. Nukaga, S. Lefurgy, K. Papp-Wallace, RA Bonomo
- Organizer
  Interscience Conference of Antimicrobial Agents and Chemotherapy 2016,Boston, MA
- Place of Presentation
  Boston
- Year and Date
  2016-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460534
[Presentation] Size Matters”: Probing the Mechanisms of Inactivation of Class C β-Lactamases with Avibactam (AVI)2016
- Author(s)
  M. Nukaga, S. T. Lefurgy, M. D. Barnes, K. M. Papp-Wallace and R. A. Bonomo
- Organizer
  56th Interscience Conference of Antimicrobial Agents and　Chemotherapy(ICAAC)
- Place of Presentation
  Boston, MA, USA.
- Year and Date
  2016-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460534
[Presentation] Exploring the Inactivation Mechanism by Avibactam (AVI) of an Inhibitor-Resistant Carbapenemase, PenA from Burkholderia multivorans (Bm)2015
- Author(s)
  K. M. Papp-Wallace, J. A. Gatta, N. Ohuchi, M. L. Winkler, S. A. Becka, J. J. LiPuma, R. A. Bonomo, M. Nukaga
- Organizer
  Interscience Conference of Antimicrobial Agents and Chemotherapy 2015,San Diego, CA
- Place of Presentation
  San Diego Convention Center
- Year and Date
  2015-09-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460534
[Presentation] Studies on the Inactivation of Enterobacter cloacae P99 Class C beta-Lactamase by Carbapenems: Doripenem, Panipenem, Imipenem and Biapenem2015
- Author(s)
  M. Nukaga, N. Ohuchi, C. R. Bethel, R. A. Bonomo
- Organizer
  Interscience Conference of Antimicrobial Agents and Chemotherapy 2015,San Diego, CA
- Place of Presentation
  San Diego Convention Center
- Year and Date
  2015-09-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460534
[Presentation] Studies on the Inactivation of Enterobacter cloacae P99 Class C beta-Lactamases by Carbapenems: Doripenem and Panipenem2013
- Author(s)
  M. Nukaga1, N. Ohuchi, C. Bethel, R. A. Bonomo
- Organizer
  53th ICAAC (Interscience Conference on Antimicrobial Agents and Chemotherapy)
- Place of Presentation
  デンバー、コロラド州、アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] Studies on the Inactivation of Enterobacter cloacae P99 Class C beta- Lactamases by Carbapenems : Doripenem and Panipenem2013
- Author(s)
  M. Nukaga, N. Ohuchi, C. Bethel, R. A. Bonomo
- Organizer
  53th ICAAC (Interscience Conference on Antimicrobial Agents and Chemotherapy)
- Place of Presentation
  デンバー(コロラド州), USA
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] The Contribution of Ambler Position P167 in Ceftazidime(TAZ) Resistance in PenI of Burkholderia pseudomallei (Bp)2012
- Author(s)
  K. M. Papp-Wallace, M. Nukaga, R. A. Bonomo
- Organizer
  52th ICAAC (Interscience Conference on Antimicrobial Agents and Chemotherapy)
- Place of Presentation
  サンフランシスコ
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] クラスCβ-ラクタマーゼの構造・反応機構・耐性化メカニズム、シンポジウム;βラクタマーゼ学2012
- Author(s)
  額賀路嘉
- Organizer
  第59回日本化学療法学会東日本支部総会
- Place of Presentation
  お台場、日航ホテル
- Invited
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] The Contribution of Ambler Po- sition P167 in Ceftazidime(TAZ) Resistance in PenI of Burkholderia pseudomallei (Bp)2012
- Author(s)
  K. M. Papp-Wallace, M. Nukaga, R. A. Bonomo
- Organizer
  52th Interscience Conference on Antimi- crobial Agents and Chemotherapy(ICAAC), Sept
- Place of Presentation
  サンフランシスコ, USA
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] クラスC β-ラクタマーゼの構造・反応機構・耐性化メカニズム2012
- Author(s)
  額賀路嘉
- Organizer
  シンポジウム；βラクタマーゼ学：構造・活性からその特徴を再考する
- Place of Presentation
  お台場、東京
- Invited
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] Crystal Structures of the Pen beta-Lactamases of Burkholde- ria cepacia (Bc) and Burkholderia pseudo- mallei (Bp)2012
- Author(s)
  K. M. Papp-Wallace, R. A. Bonomo, N. Ohuchi, M. Nukaga
- Organizer
  52th Interscience Conference on Antimicrobial Agents and Chemother- apy(ICAAC), Sept
- Place of Presentation
  サンフランシスコ, USA
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] Crystal Structures of the Pen beta-Lactamases of Burkholderia cepacia (Bc) and Burkholderia pseudomallei (Bp)2012
- Author(s)
  K. M. Papp-Wallace, R. A. Bonomo, N. Ohuchi, M. Nukaga
- Organizer
  52th ICAAC (Interscience Conference on Antimicrobial Agents and Chemotherapy)
- Place of Presentation
  サンフランシスコ
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] Structure-function studies of PenAβ-lactamase : insights into single amino acid substitutions that mediate ceftazidime (TAZ) resistance in Burkholderia pseudomallei (Bp)2011
- Author(s)
  K. M. Papp-Wallace, M. Nukaga, D.A. Rholl, H. P. Schweizer, M. Taracila, R. A. Bonomo
- Organizer
  51th Interscience Conference on Antimicro- bial Agents and Chemotherapy (ICAAC) Sept 17–20
- Place of Presentation
  Chicago, IL, USA
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] Studies on the Inactiva- tion of Class C beta-Lactamases by Aztre- onam (ATM)2011
- Author(s)
  M. Nukaga, C. R. Bethel, S. M. Drawz, R. A. Bonomo
- Organizer
  51th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Sept 17–20
- Place of Presentation
  Chicago, IL, USA
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] 14員環マクロライド抗生物質が核質タンパク性因子の細胞内動態に及ぼす影響2011
- Author(s)
  懸川友人、古庄諭美、額賀路嘉、小澤美香、小嶋文良
- Organizer
  第18回マクロライド新作用研究会
- Place of Presentation
  北里大学白金キャンパス薬学部コンベンションホール
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] Studies on the Inactivation of Class C beta-Lactamases by Aztreonam (ATM)2011
- Author(s)
  M.Nukagal, C.R.Bethel, S.M.Drawz, R.A.Bonomo
- Organizer
  51th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Sept 17-20, Chicago, IL, USA
- Place of Presentation
  Chicago, IL, USA
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] Structure-function studies of PenA β-lactamase : insights into single amino acid substitutions that mediate ceftazidime (TAZ) resistance in Burkholderia pseudomallei (Bp)2011
- Author(s)
  K.M.Papp-Wallace, M.Nukaga, D.A.Rholl, H.P.Schweizer, M.Taracila, R.A.Bonomo
- Organizer
  51th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Sept 17-20, Chicago, IL, USA
- Place of Presentation
  Chicago, IL, USA
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] Studies on the Inactivation of Class C beta-Lactamases by Carbapenems : Panipenem and P992010
- Author(s)
  NUKAGA Michiyoshi
- Organizer
  50th Interscience Conference on Antimicrobial Agents and Chemotherapy
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-22590401
[Presentation] Studies on the Inactivation of Class C beta-Lactamases by Carbapen- ems : Panipenem and P992010
- Author(s)
  M. Nukaga, C. R. Bethel, S. Drawz, R. A. Bonomo
- Organizer
  50th Inter- science Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Sept. 12–15
- Place of Presentation
  Boston, MA, USA
- Data Source
  KAKENHI-PROJECT-22590401

1. HOSHINO Chuji (90257220)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. OHUCHI Nozomi (20398556)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. TANAKA Nobutada (00286866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KAKEGAWA Tomohito (80169391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. BONOMO Robert

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
6. James R Knox

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Robert Bonomo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nukaga Michiyoshi 額賀 路嘉

NUKAGA Michiyoshi 額賀 路嘉

額賀 路嘉 ヌカガ ミチヨシ

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X-ray crystallographic analysis of penicillin-recognizing enzyme for the search of non-covalent inhibitorsPrincipal Investigator

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Structure basis of reaction mechanism of beta-lactamases and new inhibitor searchPrincipal Investigator

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Ultra high resolution Xray crystallographic study for antibiotic mechanisms of action and resistancePrincipal Investigator

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X-ray Crystallographic Study of Antibiotics resistant ProteinsPrincipal Investigator

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基質特異性拡張型β−ラクタマーゼの活性中心構造とその分子進化Principal Investigator

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クラスCβ-ラクタマーゼHelix8,9間ループの基質特異性に与える影響Principal Investigator

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[Journal Article] Development of Inhibitory Compounds for Metallo-beta-lactamase through Computational Design and Crystallographic Analysis2024

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[Journal Article] Assessing the Potency of β-Lactamase Inhibitors with Diverse Inactivation Mechanisms against the PenA1 Carbapenemase from Burkholderia multivorans.2021

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[Journal Article] Identification of the Inhibitory Compounds for Metallo-β-lactamases and Structural Analysis of the Binding Modes2021

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[Journal Article] Overcoming an Extremely Drug Resistant (XDR) Pathogen: Avibactam Restores Susceptibility to Ceftazidime for Burkholderia cepacia Complex Isolates from Cystic Fibrosis Patients.2017

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[Journal Article] クラスCβ-ラクタマーゼー構造、反応機構、進化2015

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[Journal Article] In- sights intoβ-lactamases from Burkholderia species, two phylogenetically related yet dis- tinct resistance determinants2013

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[Journal Article] β-ラクタマーゼの構造から考える耐性獲得機構、オキシイミノ系およびカルバペネム系β-ラクタム剤を中心に2013

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[Journal Article] Insights into β-lactamases from Burkholderia species, two phylogenetically related yet distinct resistance determinants.2013

Author(s)

Nukaga Michiyoshi 額賀路嘉

NUKAGA Michiyoshi 額賀路嘉

額賀路嘉ヌカガミチヨシ