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YASUGI Toshiharu  八杉 利治

ORCIDConnect your ORCID iD *help
Researcher Number 20251267
Affiliation (based on the past Project Information) *help 2009: がん・感染症センター, 都立駒込病院婦人科, 医長
2008: 東大, 医学部附属病院, 講師
2007: The University of Tokyo, 医学部・附属病院, 講師
2005 – 2007: 東京大学, 医学部附属病院, 講師
2005 – 2006: 東京大学, 医学部, 講師 … More
2001 – 2004: 東京大学, 医学部, 助手
1998 – 2000: 東京大学, 医学部・附属病院, 助手
1995: Univ.Tokyo Hospital, Dept.Ob & Gyn, Associate, 医学部, 助手
1994 – 1995: 東京大学, 医学部(病), 助手 Less
Review Section/Research Field
Principal Investigator
Obstetrics and gynecology / Obstetrics and gynecology
Except Principal Investigator
Obstetrics and gynecology / Obstetrics and gynecology / Biological Sciences
Keywords
Principal Investigator
PI3K pathway / p53 / prognosis / tumor suppressor protein / endometrial carcinomas / 予後 / 癌抑制蛋白 / 子宮体癌 / 治療ワクチン / 乳酸菌 … More / ヒトパピローマウイルス(HPV) / 子宮頸癌 / 婦人科腫瘍 / hUBC9 / E2蛋白 / ヒトパピローマウイルス / TACC3 / EIF3A / 変異導入 / E1蛋白 / DNA複製 / ヒトパピローマウィルス … More
Except Principal Investigator
HPV / CIN / 子宮頸癌 / E6 / VLP / L2 / Cervical Cancer / 子宮頚癌 / 中和抗体 / ワクチン / HLA / HPV IgG / L2 epitope / neutralizing antibody / E7 / variant / PCR / PTEN / metaanalysis / cervical cancer / vaccine / 腺癌 / 免疫 / CIN消失 / IgG抗体 / コホート / 細胞性免疫 / L1-capsids / 液性免疫 / メタアナリシス / II trial / Phase I / Vaccine / variants / VLP抗体 / 子宮頚がん / II相試験 / 第I / Human Papillomavirus (HPV) / Variant / DNAワクチン / ヒトパピローマウイルス(HPV) / ヒトパピローマウィルス(HPV) / Vulvar Cancer / 血清疫学 / 分子疫学 / 外陰癌 / PI3K / 婦人科腫瘍 / 悪性転化 / PIK3CA / 乳癌 / 子宮体癌 / gynecologic malignancy / PI3' kinase / Ras / エピトープ / バキュロウイルス / キメラワクチン / L2ワクチン / VLPワクチン / 地域差 / 発癌リスク / 変異体 / HLA Class II / HPV16 / DQB1 / DRB1 / リスク因子 / 症;例対照研究 / 民族差 Less
  • Research Projects

    (10 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (12 People)
  •  Development of a prophylactic vaccine effective against a broader spectrum of HPVs associated with cervical cancer and basic research on therapeutic HPV vaccine for cervical cancer

    • Principal Investigator
      YOSHIKAWA Hiroyuki
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      University of Tsukuba
  •  ヒトパピローマウイルス持続感染排除を目指した乳酸菌ワクチンの基礎的研究Principal Investigator

    • Principal Investigator
      八杉 利治
    • Project Period (FY)
      2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      The University of Tokyo
  •  Role of Ras signaling pathway activation in oncogenic transformation of gynecologic malignancies

    • Principal Investigator
      ODA Katsutoshi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      The University of Tokyo
  •  子宮頚部発がんの宿主要因としてのHLA遺伝子多型に関する民族疫学的研究

    • Principal Investigator
      YOSHIKAWA Hiroyuki
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba
  •  Basic research of cell proliferation and apoptosis through p53/PTEN/Ras pathwayPrincipal Investigator

    • Principal Investigator
      YASUGI Toshiharu
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      The University of Tokyo
  •  Study on development of HPV vaccine and the use for prevention of cervical cancer

    • Principal Investigator
      YOSHIKAWA Hiroyuki
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      University of Tsukuba
  •  Basic Research on development of HPV vaccine for prevention of cervical cancer

    • Principal Investigator
      YOSHIKAWA Hiroyuki
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      UNIVERSITY OF TSUKUBA
  •  Immunological study for prevention and treatment of HPV-positive cervical cancer.

    • Principal Investigator
      YOSHIKAWA Hiroyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      University of Tokyo
  •  変異導入を用いたHPV16EIとその細胞内結合蛋白の機能解析Principal Investigator

    • Principal Investigator
      八杉 利治
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      The University of Tokyo
  •  Epidemiologic study on HPV infection for protecting generation of cervical cancer

    • Principal Investigator
      YOSHIKAWA Hiroyuki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      University of Tokyo

All 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article

  • [Journal Article] Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E72010

    • Author(s)
      Adachi K, Kawana K(13人中2番目), Yasugi T(13人中11番目), et al.
    • Journal Title

      Vaccine (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390424
  • [Journal Article] The Optimal Debulking After Neoadjuvant Chemotherapy in Ovarian Cancer ; Proposal Based on Interval Look During Upfront Surgery Setting Treatment2010

    • Author(s)
      Onda T, Yoshikawa H (5人中2番目), Yasugi T (5人中3番目), et al.
    • Journal Title

      Jpn J Clin Oncol 40(1)

      Pages: 36-41

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390424
  • [Journal Article] Human papillomavirus vaccines : current issues & future2009

    • Author(s)
      Kawana K (3人中1番目), Yasugi T (3人中2番目), et al.
    • Journal Title

      Indian J Med Res.Review 130(3)

      Pages: 341-347

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390424
  • [Journal Article] a human homologue of Drosophila neoplastic tumor suppressor, is a novel death substrate targeted by caspase during the process of apoptosis2008

    • Author(s)
      Sone K, Nakagawa S, Nakagawa K, Takizawa S, Matsumoto Y, Nagasaka K, Tsuruga T, Hiraike H, Hiraike-Wada O, Miyamoto Y, Oda K, Yasugi T, Kugu K, Yano T, Taketani Y. hScrib
    • Journal Title

      Genes Cells 13(7)

      Pages: 771-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19599005
  • [Journal Article] Neutralizing antibodies against human papillomavirus types of 16, 18, 31, 52, and 58 in the serum samples from Japanese women with low grade cervical intraepithelial neoplasia2008

    • Author(s)
      Ochi H, Matsumoto K (9人中3番目), Yasugi T (9人中5番目), Yoshikawa H (9人中8番目), et al.
    • Journal Title

      Clin Vaccine Immunol 15(10)

      Pages: 1536-1540

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390424
  • [Journal Article] Analysis of the status of the novel estrogen receptor alpha (Eralpha) coactivator p72 in endometrial cancer and its cross talk with erbB-2 in the transactivation of Eralpha2008

    • Author(s)
      Zhao L Watanabe M, Yano T, Yanagisawa J, Nakagawa S, Oishi H, Wada-Hiraike O, Oda K, Minaguchi, T, Yasugi T, Kato S, Taketani Y
    • Journal Title

      Molecular Medicine Reports 1

      Pages: 387-390

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19599005
  • [Journal Article] Combined phospho-Akt and PTEN expressions associated with post-treatment hysterectomy after conservative progestin therapy in complex atypical hyperplasia and stage Ia, G1 adenocarcinoma of the endometrium.2007

    • Author(s)
      Minaguchi T, Nakagawa S, Takazawa Y, Nei T, Horie K, Fujiwara T, Osuga Y, Yasugi T, Kugu K, Yano T, Yoshikawa H, Taketani Y.
    • Journal Title

      Cancer Lett 248(1)

      Pages: 112-122

    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] Loss of Hugl-1 expression associates with lymph node metastasis in endometrial cancer.2007

    • Author(s)
      Tsuruga T, Nakagawa S, Watanabe M, Takizawa S, Matsumoto Y, Nagasaka K, Sone K, Hiraike H, Miyamoto Y, Hiraike O, Minaguchi T, Oda K, Yasugi T, Yano T, Taketani Y.
    • Journal Title

      Oncologic Research 16(9)

      Pages: 431-435

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591926
  • [Journal Article] Treatment with paclitaxel plus carboplatin, alone or with irradiation, of advanced or recurrent endometrial carcinoma.2007

    • Author(s)
      Arimoto T, Nakagawa S, Yasugi T, Yoshikawa H, Kawana K, Yano T, Taketani Y.
    • Journal Title

      Gynecol Oncol 104(1)

      Pages: 32-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] Treatment with paclitaxel plus carboplatin, alone or with irradiation, of advanced or recurrent endometrial carcinoma.2007

    • Author(s)
      Arimoto T, Nakagawa S, Yasugi T, Yoshikawa H, Kawana K, Yano T, Taketani Y
    • Journal Title

      Gynecol Oncol 104(1)

      Pages: 32-35

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women.2007

    • Author(s)
      Ushijima K, Yahata H, Yoshikawa H, Konishi I, Yasugi T, Saito T, Nakanishi T, Sasaki H, Saji F, Iwasaka T, Hatae M, Kodama S, Saito T, Terakawa N, Yaegashi N, Hiura M, Sakamoto A, Tsuda H, Fukunaga M. Kamura T.
    • Journal Title

      Journal of Clinical Oncology 25(19)

      Pages: 2798-2803

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591926
  • [Journal Article] Fertility-Sparing Treatment with Medroxyprogesterone Acetate for Endometrial Carcinoma and Atypical Hyperplasia in Young Women : A Multicenter Phase II Study2007

    • Author(s)
      Ushijima K, Yoshikawa H (20人中3番目), Yasugi T (20人中5番目), et al.
    • Journal Title

      J Clin Oncol 25(19)

      Pages: 2798-2803

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390424
  • [Journal Article] Treatment with paclitaxel plus carboplatin, alone or with irradiation, of advanced or recurrent endometrial carcinoma2007

    • Author(s)
      Arimoto T, Yasugi T (7人中3番目), Yoshikawa H (7人中4番目), Kawana K (7人中5番目), et al.
    • Journal Title

      Gynecol Oncol 104(1)

      Pages: 32-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390424
  • [Journal Article] Combined phospho-AKt and PTEN expressions associated with post-treatment hysterectomy after conservative progestin therapy in complex atypical hyperplasia and stage Ia, G1 adenocarcinoma of the endometrium.2007

    • Author(s)
      Minaguchi T, Nakagawa S, Takazawa Y, Nei T, Horie K, Fujiwara T, Osuga Y, Yasugi T, Kugu K, Yano T, Yoshikawa H, Taketani Y.
    • Journal Title

      Cancer Lett. Apr 8,248(1)

      Pages: 112-122

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] Combined phospho-Akt and PTEN expressions associated with post-treatment hysterectomy after conservative progestin therapy in complex atypical hyperplasia and stage Ia, G1 adenocarcinoma of the endometrium2007

    • Author(s)
      Minaguchi T, Yasugi T (12人中8番目), Yoshikawa H (12人中11番目), et al.
    • Journal Title

      Cancer Letters 248(1)

      Pages: 112-122

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390424
  • [Journal Article] Combined phospho-Akt and PTEN expressions associated with post-treatment hysterectomy after conservative progestin therapy in complex atypical hyperplasia and stage Ia, G1 adenocarcinoma of the endometrium.2007

    • Author(s)
      Minaguchi T, Nakagawa S, Takazawa Y, Nei T, Horie K, Fujiwara T, Osuga Y, Yasugi T, Kugu K, Yano T, Yoshikawa H, Taketani Y
    • Journal Title

      Cancer Lett 248(1)

      Pages: 112-122

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] Loss of Hugl-1 expression associates with lymph node metastasis in endometrial cancer2007

    • Author(s)
      Tsuruga T, Nakagawa S, Watanabe M, Takizawa S, Matsumoto Y, Nagasaka K, Sone K, Hiraike H, Miyamoto Y, Hiraike O, Minaguchi T, Oda K, Yasugi T, Yano T, Taketani Y
    • Journal Title

      Oncol Res 16(9)

      Pages: 431-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19599005
  • [Journal Article] Human papillomavirus type 16 P670 promoter is negatively regulated by CCAAT2007

    • Author(s)
      Sato K, Takeuchi T, Kukimoto I, Mori S, Yasugi T, Yano T, Taketani Y, Kanda T.
    • Journal Title

      Virus Genes 35(3)

      Pages: 473-481

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591926
  • [Journal Article] Do we need a different strategy for HPV screening and vaccination in East Asia?2006

    • Author(s)
      Miura S, Matsumoto K, Oki A, Satoh T, Tsunoda H, Yasugi T, Taketani Y, Yoshikawa H.
    • Journal Title

      Int J Cancer Dec 1,119(11)

      Pages: 2713-2715

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6.2006

    • Author(s)
      Matsumoto Y, Nakagawa S, Yano T, Takizawa S, Nagasaka K, Nakagawa K, Minaguchi T, Wada O, Ooishi H, Matsumoto K, Yasugi T, Kanda T, Huibregtse JM, Taketani Y.
    • Journal Title

      Journal of Medical Virology 78(4)

      Pages: 501-507

    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] Methylation and expression analysis of 15 genes and three normally-methylated genes in 13 Ovarian cancer cell lines.2006

    • Author(s)
      Imura M, Yamashita S, Cai LY, Furuta JI, Wakabayashi M, Yasugi T, Ushijima T.
    • Journal Title

      Cancer Letters 19(印刷中)

    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] Do we need a different strategy for HPV screening and vaccination in East Asia?2006

    • Author(s)
      Miura S, Matsumoto K, Oki A, Satoh T, Tsunoda H, Yasugi T, Taketani Y, Yoshikawa H.
    • Journal Title

      Int J Cancer 119(11)

      Pages: 2713-2715

    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] 3-D fractal tumor growth of epithelial ovarian cancer.2006

    • Author(s)
      Kikuchi A, Kozuma S, Yasugi T, Taketani Y
    • Journal Title

      Eur J Gynaecol Oncol 27(6)

      Pages: 561-565

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia.2006

    • Author(s)
      Matsumoto K, Yasugi T, Oki A, Fujii T, Nagata C, Sekiya S, Hoshiai H, Taketani Y, Kanda T, Kawana T, Yoshikawa H.
    • Journal Title

      Cancer Letters 18

      Pages: 309-313

    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] Do we need a different strategy for HPV screening and vaccination in East Asia?2006

    • Author(s)
      Miura S, Matsumoto K, Oki A, Satoh T, Tsunoda H, Yasugi T, Taketani Y, Yoshikawa H
    • Journal Title

      Int J Cancer 119(11)

      Pages: 2713-2715

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] 3-D fractal tumor growth of epithelial ovarian cancer.2006

    • Author(s)
      Kikuchi A, Kozuma S, Yasugi T, Taketani Y.
    • Journal Title

      Eur J Gynaecol Oncol 27(6)

      Pages: 561-565

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] Comparison between conventional surgery and radiotherapy for FIGO stage I-II cervical carcinoma : a retrospective Japanese study2005

    • Author(s)
      Yamashita H, Nakagawa K, Tago M, Shiraishi K, Nakamura N, Ohtomo K, Oda K, Nakagawa S, Yasugi T, Taketani Y.
    • Journal Title

      Gynecologic Oncology 97(3)

      Pages: 834-839

    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha.2005

    • Author(s)
      Wada-Hiraike O, Yano T, Nei T, Matsumoto Y, Nagasaka K, Takizawa S, Oishi H, Arimoto T, Nakagawa S, Yasugi T, Kato S, Taketani Y.
    • Journal Title

      British Journal of Cancer 92(12)

      Pages: 2286-2291

    • Data Source
      KAKENHI-PROJECT-17591720
  • [Journal Article] A novel method of preoperative autologous blood donation with a large volume of plasma for surgery in gynecologic malignancies.2004

    • Author(s)
      Miki A, Yoshikawa H, Yasugi T, et al.
    • Journal Title

      Transfus Apheresis Sci. 31(1)

      Pages: 21-28

    • Data Source
      KAKENHI-PROJECT-16390472
  • [Journal Article] Association of PTEN mutation with HPV-negative adenocarcinoma of the uterine cervix.2004

    • Author(s)
      Minaguchi T, Yoshikawa H, Yasugi T, et al.
    • Journal Title

      Cancer Lett. 210(1)

      Pages: 57-62

    • Data Source
      KAKENHI-PROJECT-16390472
  • [Journal Article] IgG antibodies to HPV 16,52,58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia

    • Author(s)
      Matsumoto K, Yasugi T, Yoshikawa H, et al.
    • Journal Title

      Cancer Lett (In press)

    • Data Source
      KAKENHI-PROJECT-16390472
  • 1.  YOSHIKAWA Hiroyuki (40158415)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 8 results
  • 2.  MATSUMOTO Kouji (30302714)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 3.  KAWANA Kei (60311627)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 4.  ODA Katsutoshi (30359608)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 5.  TSUNODA Hajime (60197754)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  TADAUCHI Kaoru (90260497)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  ONDA Takeshi (40251269)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  YOKOTA Harusige (40182696)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  OKI Akinori (60334067)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  高塚 直能 (00293556)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  前田 平生 (30134597)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  市川 喜仁 (30302425)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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