Shinya Kazuo 新家一男

… Alternative Names

Researcher Number	20251481
Affiliation (Current)	2020: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長
Affiliation (based on the past Project Information) *help	2017 – 2020: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長 2016: 国立研究開発法人産業技術総合研究所, その他部局等, 研究員 2015: 国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 上級主任研究員 2014: 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 上級主任研究員 2013: 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 研究グループ長 … More
Review Section/Research Field	Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Bioproduction chemistry/Bioorganic chemistry / Biological Sciences / Medium-sized Section 37:Biomolecular chemistry and related fields Except Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Science and Engineering / Drug development chemistry / Applied molecular and cellular biology / Basic Section 40040:Aquatic life science-related
Keywords	Principal Investigator グルタミン酸毒性 / kaitocephalin / 脳虚血疾患 / AMPA / 海馬神経細胞 / スクリーニング / 天然化合物 / NMDA / halxazone / 神経細胞 … More Except Principal Investigator TANGO-HMBC / BE-40644 / グルタミン酸レセプター / decoupled-HMBC / D-HMBC / メバロン酸経路 / 非メバロン酸経路 / longestin / carquinostatin / HMG CoA reductase / novobiocin / 2-C-methyl-D-erythritol 2,4-cyclodiphosphate / 3-hydroxy-3-methylglutaryl coenzyme A reductase / 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol / Kaitocephalin / Telomestatin / ビオチン化 / テロメラーゼ / テロメア / 神経細胞保護 / グルタミンレセプター / 神経細胞毒性 / カイトセファリン / アンタゴニスト / 立体選択的合成 / アンダゴニスト / 小胞体ストレス / 分子シャペロン / GRP78 / アデノウイルスがん遺伝子 / versipelostatin / piericidin / efrapeptin / thioviridamide / ammocidin / IGF / tyroscherin / 立体異性体 / 構造活性相関 / レポーターアッセイ / prunustatin A / Tolypocladium / 固形癌 / 呼吸阻害剤 / アポトーシス / アデノウイルス / がん遺伝子 / チオアミド / 天然生理活性物質 / 標的分子 / エピジェネティクス / 合成致死遺伝子 / 分子間相互作用 / モルスコープ / コンピューターによる立体構造解析 / プロモインドシン / スタキボシン / プロモチオシン / ゲニンチオシン / セコスリキサイド / コンピュータによる立体構造解析 / MolSkop / analysis of stereo-structures by computer calculation / naphterpin / BE-40644の生合成 / テルペノイド化合物の生合成 / Streptomyces aeriouvider / HMG CoAreducatase / Streptomyces aeriouvifer / ナフテルピンの生合成 / メナキノンの生合成 / Streptomyces argenteolus / ロンゲスチンの生合成研究 / non-mevalonate pathway / HMG Co-A reductase / Streptomyces aureouvifer / 3-hydroxy-3-methylglutaryl coezyme A reductase / 2-C-methyl-D-erythritol4-phosphate / 4-(cytidine5'-diphospho)-2-C-methyl-D-erythritol / 2-phospho-4-(cytidine5'-diphospho)-2-C-methyl-D-erythritol / 1-deoxyxylulose5-phosphate reductoisomerase / 2-C-methyl-D-erythriitol 4-phosphate / 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase / 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase / 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol / 1-deoxyxylulose / ノボビオシン / 2-C-methylerythritol / 1-deoxyxylulose 5-phosphate reductoisomerase / 2-C-methyl-D-erythritol 4-phosphate / 2-phospho-4-(cytidine 5' -diphospho)-2-C-methyl-D-erythritol / 1- deoxyxylulose 5-phosphate reductoisomerase / mevalonate pathway / nonmevalonate pathway / メタゲノム / 海洋天然物 / 生合成遺伝子 / 海綿 / 共生微生物 Less

メタゲノミクスによる海綿における天然有機化合物生産機構の解明Ongoing
- Principal Investigator
  
  末永光
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 40040:Aquatic life science-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Fermentative production of rare natural compounds found in marine organisms living in the seas of ThailandPrincipal InvestigatorOngoing
- Principal Investigator
  
  新家一男
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Development of novel methods for target identification of natural products and chemical epigeneticsOngoing
- Principal Investigator
  
  吉田稔
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Institute of Physical and Chemical Research
Studies on screening for substances which act on cancer stem cells established from tumors surgically excised from brain tumor patients.Principal Investigator
- Principal Investigator
  
  SHIN-YA Kazuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Studies on screening for bioactive compounds targeting gene repair, recombination and splicing systems.Principal Investigator
- Principal Investigator
  
  SHINYA Kazuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Screening for microbial metabolites that regulate cellular stress response
- Principal Investigator
  
  早川洋一
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Science
グルタミン酸毒性の発現・抑制機講解明を指向したカイトセファリンの合成と応用研究
- Principal Investigator
  
  渡邉秀典
- Project Period (FY)
  2002 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
微生物由来のテロメラーゼ阻害物質telomestatinに関する研究Principal Investigator
- Principal Investigator
  
  新家一男
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
BIAcoreを用いた標識化低分子化合物をプローブとした複合タンパク質の探索研究
- Principal Investigator
  
  HAYAKAWA Yoichi
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
Studies on apoptosis regulators substances of microbial origin aiming at neuroprotectionPrincipal Investigator
- Principal Investigator
  
  SHIN-YA Kazuo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
Biosynthetic studies on terpenoids produced by Actinomycetes by focusing on the nonmevalonate pathway
- Principal Investigator
  
  SETO Haruo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
Studies on substances of microbial origin which protect central nervous systemPrincipal Investigator
- Principal Investigator
  
  SHIN-YA Kazuo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
微生物の生産する脳中枢神経細胞保護物質に関する研究Principal Investigator
- Principal Investigator
  
  新家一男
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
Biosynthetic Studies of terpenoids produced by actinomycetes
- Principal Investigator
  
  SETO Haruo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
脳中枢神経細胞保護物質の微生物からの探索研究Principal Investigator
- Principal Investigator
  
  新家一男
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
中枢神経細胞保護物質の微生物からの探索研究Principal Investigator
- Principal Investigator
  
  新家一男
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
DEVELOPMENT OF NEW NMR TECHNIQUES AND THEIR APPLICATION TO STRUCTURAL ANALYSIS OF NATURAL PRODUCTS
- Principal Investigator
  
  SETO Haruo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES,UNIVERSITY OF TOKYO

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] JBIR-150, a novel 20-membered polyene macrolactam from marine-derived Streptomyces sp. OPMA000712018
- Author(s)
  Kawahara T, Fujiwara T, Kagaya N, Shin-ya K
- Journal Title
  
  J. Antibiot.
  
  Volume: 71 Pages: 390-392
- DOI
  10.1038/s41429-017-0010-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221204
[Journal Article] Neothioviridamide, a poly thioamide compound produced by heterologous expression of a Streptomyces sp. cryptic RiPP biosynthetic gene cluster2018
- Author(s)
  Kawahara T, Izumikawa M, Kozone I, Hashimoto J, Kagaya N, Koiwai H, Komatsu M, Fujie M, Sato N, Ikeda H, Shin-Ya K.
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 81 Pages: 264-269
- DOI
  10.1021/acs.jnatprod.7b00607
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07674, KAKENHI-PLANNED-16H06447, KAKENHI-PROJECT-26221204
[Journal Article] Novel arginine-containing peptides MBJ-0173 and MBJ-0174 from Mortierella alpina f28740.2017
- Author(s)
  Kawahara T, Itoh M, Kozone I, Izumikawa M, Sakata N, Tsuchida T, Shin-ya K.
- Journal Title
  
  J. Antibiot.
  
  Volume: 70 Pages: 226-229
- DOI
  10.1038/ja.2016.116
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221204
[Journal Article] MBJ-0110, a novel cyclopeptide isolated from the fungus Penicillium sp. f252672016
- Author(s)
  Kawahara, T., Itoh, M., Kozone, I., Izumikawa, M., Sakata, N., Tsuchida, T., and Shin-ya, K.
- Journal Title
  
  J. Antibiot.
  
  Volume: 69 Pages: 66-68
- DOI
  10.1038/ja.2015.78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221204
[Journal Article] JBIR-76 and JBIR-77, modified naphthoquinones from Streptomyces sp. RI-77.2016
- Author(s)
  Motohashi K, Izumikawa M, Kagaya N, Takagi M, Shin-ya K.
- Journal Title
  
  J. Antibiot.
  
  Volume: 69 Pages: 707-708
- DOI
  10.1038/ja.2015.135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221204
[Journal Article] Pyrrolidine-containing peptides, JBIR-126, -148 and -149, from Streptomyces sp. NBRC 1112282015
- Author(s)
  Izumikawa, M., Kawahara, T., Kagaya, N., Yamamura, H., Hayakawa, M., Takagi, M., Yoshida, M., Doi, T., and Shin-ya, K.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 56 Pages: 5333-5336
- DOI
  10.1016/j.tetlet.2015.07.080
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221204
[Journal Article] Novel thioviridamide derivative--JBIR-140: heterologous expression of the gene cluster for thioviridamide biosynthesis.2015
- Author(s)
  Izumikawa M, Kozone I, Hashimoto J, Kagaya N, Takagi M, Koiwai H, Komatsu M, Fujie M, Satoh N, Ikeda H, Shin-Ya K.
- Journal Title
  
  J. Antibiot (Tokyo)
  
  Volume: 印刷中 Pages: 533-536
- DOI
  10.1038/ja.2015.20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25450112, KAKENHI-PROJECT-26221204
[Journal Article] Foxo3a inhibitors of microbial origin, JBIR-141 and JBIR-1422015
- Author(s)
  Teppei Kawahara, Noritaka Kagaya, Yuichi Masuda, Takayuki Doi, Miho Izumikawa, Kumiko Ohta, Atsushi Hirao, Kazuo Shin-ya
- Journal Title
  
  Org Lett.
  
  Volume: 17 Pages: 5476-5479
- DOI
  10.1021/acs.orglett.5b02842
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19548, KAKENHI-PROJECT-26850068, KAKENHI-PUBLICLY-15H01509, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-15H02361
[Journal Article] New hydroxamate metabolite, MBJ-0003, from Micromonospora sp. 298672014
- Author(s)
  Teppei Kawahara, Masashi Itoh, Miho Izumikawa, Ikuko Kozone, Noriaki Sakata, Toshio Tsuchida and Kazuo Shin-ya
- Journal Title
  
  J. Antibiot.
  
  Volume: 67 (3)(sp. 29867) Pages: 21-263
- DOI
  10.1038/ja.2013.124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380067
[Journal Article] New chaetoglobosin derivatives, MBJ-0038, MBJ-0039 and MBJ-0040, isolated from the fungus Chaetomium sp. f242302013
- Author(s)
  Teppei Kawahara, Masashi Itoh, Miho Izumikawa, Noriaki Sakata, Toshio Tsuchida and Kazuo Shin-ya
- Journal Title
  
  J. Antibiot.
  
  Volume: 66 (12)(sp. F24230) Pages: 727-730
- DOI
  10.1038/ja.2013.75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380067
[Journal Article] Cytotoxic sesquiterpenoids MBJ-0009 and MBJ-0010 from a saprobic fungus Nectria sp. f261112013
- Author(s)
  Teppei Kawahara, Masashi Itoh, Miho Izumikawa, Noriaki Sakata, Toshio Tsuchida and Kazuo Shin-ya
- Journal Title
  
  J. Antibiot.
  
  Volume: 66 (9)(sp. F26111) Pages: 567-569
- DOI
  10.1038/ja.2013.45
- NAID
  10031201655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380067
[Journal Article] JBIR-137 and JBIR-138, new secondary metabolites from Aspergillus sp. fA75J.2012
- Author(s)
  Teppei Kawahara, Aya Nagai, Motoki Takagi and Kazuo Shin-ya
- Journal Title
  
  J. Antibiot.
  
  Volume: 65 (10)(sp.fA75J) Pages: 535-538
- DOI
  10.1038/ja.2012.64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380067
[Journal Article] JBIR-129 and -139, cytotoxic 34-membered polyol macrolides of microbial origin.2012
- Author(s)
  Teppei Kawahara, Ji-Hwan Hwang, Miho Izumikawa, Junko Hashimoto, Motoki Takagi and Kazuo Shin-ya
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 133 (10) Pages: 1638-1641
- DOI
  10.1021/np3004358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380067
[Journal Article] A new cyclizidine analog-JBTR-102-from Saccharopolyspora sp.RL78 isolated from mangrove soil2012
- Author(s)
  Miho Izumikawa, Takahiro Hosoya, Motoki Takagi and Kazuo Shin-ya
- Journal Title
  
  J.Antibiot.
  
  Volume: 65 (1) Pages: 41-43
- DOI
  10.1038/ja.2011.99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380067
[Journal Article] Relative configuration of JBIR-129, a cytotoxic 34-membered glycosidic polyol macrolide from Streptomyces sp. RK74.2012
- Author(s)
  Teppei Kawahara, Miho Izumikawa Motoki Takagi and Kazuo Shin-ya
- Journal Title
  
  Org. Lett.
  
  Volume: 14 (17)(sp.RK74) Pages: 4434-4437
- DOI
  10.1021/ol301940q
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380067
[Journal Article] New angucycline C-glycosides from Streptomyces sp.RI332011
- Author(s)
  Jun-ya Ueda, Miho Izumikawa, Akira Mukai, Aya Nagai, Ji-Hwan Hwang, Motoki Takagi and Kazuo Shin-ya
- Journal Title
  
  J.Antibiot.
  
  Volume: 64(5)(sp.RI33) Pages: 367-372
- DOI
  10.1038/ja.2011.8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380067
[Journal Article] A new angucycline and a new butenolide isolated from lichen-derived Streptomyces spp.2010
- Author(s)
  K.Motohashi, M.Takagi, H.Yamamura, M.Hayakawa, K.Shin-ya
- Journal Title
  
  J.Antibiot.
  
  Volume: 63(9) Pages: 545-548
- NAID
  10030710013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] Anti-influenza virus compound from Streptomyces sp.RI18.2010
- Author(s)
  M.Takagi, K.Motohashi, A.Nagai, M.Izumikawa, M.Tanaka, S.Fuse, T.Doi, K.Iwase, A.Kawaguchi, K.Nagata, T.Takahashi, K.Shin-ya
- Journal Title
  
  Org.Lett.
  
  Volume: 12(20) Pages: 4664-4666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] A new angucycline and a new butenolide isolated from lichen-derived Streptomyces spp.2010
- Author(s)
  Keiichiro Motohashi, Motoki Takagi, Hideki Yamamura, Masayuki Hayakawa, Kazuo Shin-ya.
- Journal Title
  
  J.Antibiot. 63(9)
  
  Pages: 545-548
- NAID
  10030710013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] JBIR-97, -98 and -99, obtained from marine sponge-derived fungus Tritirachium sp.SpB081112MEf2.2010
- Author(s)
  J.Ueda, M.Takagi, K.Shin-ya
- Journal Title
  
  J.Antibiot.
  
  Volume: 63(10) Pages: 627-629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] JBIR-69, a new peptide metabolite from Streptomyces sp.OG05.2010
- Author(s)
  Takeshi Fujiwara, Aya Nagai, Motoki Takagi, Kazuo Shin-ya.
- Journal Title
  
  J.Antibiot. 63(2)
  
  Pages: 95-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] JBIR-69, a new peptide metabolite from Streptomyces sp.OG05.2010
- Author(s)
  Takeshi Fujiwara, Aya Nagai, Motoki Takagi, Kazuo Shin-ya
- Journal Title
  
  J.Antibiot. 63
  
  Pages: 95-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] New xanthoquinodin-like compounds, JBIR-97, -98 and -99, obtained from marine sponge-derived fungus Tritirachium sp.SpB081112MEf2.2010
- Author(s)
  Jun-ya Ueda, Motoki Takagi, Kazuo Shin-ya
- Journal Title
  
  J.Antibiot. 63(10)
  
  Pages: 615-618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] JBIR-52, a novel antimycin-like compound, from Streptomyces sp.ML552009
- Author(s)
  Ikuko Kozone, Jun-ya Ueda, Motoki Takagi, Kazuo Shin-ya
- Journal Title
  
  J.Antibiot. 62
  
  Pages: 593-595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea.2009
- Author(s)
  Takeshi Fujiwara, Ji-Hwan Hwang, Akihiko Kanamoto, Hiroshi Nagai, Motoki Takagi, Kazuo Shin-ya.
- Journal Title
  
  J.Antibiot. 62(7)
  
  Pages: 393-395
- NAID
  10030635826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB272009
- Author(s)
  K. Motohashi, J. -H. Hwang, M. Takagi, K Shin-ya
- Journal Title
  
  Org. Lett. 11
  
  Pages: 285-288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] JBIR-17, a novel trichostatin analogue from Streptomyces sp.266342009
- Author(s)
  Jun-ya Ueda, Ji-Hwan Hwang, Taira Kato, Atsushi Ochiai, Kunio Isshiki, Motoki Takagi, Kazuo Shin-ya
- Journal Title
  
  J.Antibiot. 62
  
  Pages: 283-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp2009
- Author(s)
  Murakami, R., Shinozaki, J., Kajiura, T., Kozone, I., Takagi, M., Shin-ya, K., Seto, H., Hayakawa, Y.
- Journal Title
  
  AJ9571. J. Antibiot. 62
  
  Pages: 123-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390031
[Journal Article] JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea.2009
- Author(s)
  Takeshi Fujiwara, Ji-Hwan Hwang, Akihiko Kanamoto, Hiroshi Nagai, Motoki Takagi, Kazuo Shin-ya
- Journal Title
  
  J.Antibiot. 62
  
  Pages: 393-395
- NAID
  10030635826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] New glycosylated derivatives of versipelostatin, the GRP78/Bipmolecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS6.2009
- Author(s)
  Ping Zhao, Jun-ya Ueda, Ikuko Kozone, Shuhei Chijiwa, Motoki Takagi,Fumitaka Kudo, Makoto Nishiyama, Kazuo Shin-ya, Tomohisa Kuzuyama.
- Journal Title
  
  Org.Biomol.Chem. 7(7)
  
  Pages: 144-1460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] JBIR-17, a novel trichostatin analogue from Streptomyces sp.26634.2009
- Author(s)
  Jun-ya Ueda, Ji-Hwan Hwang, Taira Kato, Atsushi Ochiai, Kunio Isshiki, Motoki Takagi, Kazuo Shin-ya.
- Journal Title
  
  J.Antibiot. 62(5)
  
  Pages: 283-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB27.2009
- Author(s)
  Keiichiro Motohashi, Ji-Hwan Hwang, Motoki Takagi, Kazuo Shin-ya.
- Journal Title
  
  Org.Lett. 11(2)
  
  Pages: 285-288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin.2009
- Author(s)
  Junichi Matsuo, Yoshinori Tsukumo, Junko Sakurai, Satomi Tsukahara, Hae-Ryong Park, Kazuo Shin-ya, Toshiki Watanabe, Takashi Tsuruo, Akihiro Tomida.
- Journal Title
  
  Cancer Sci. 100(2)
  
  Pages: 327-333
- NAID
  10025142654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS62009
- Author(s)
  P. Zhao, J. Ueda, I. Kozone, S. Chijiwa, M. Takagi, F. Kudo, M. Nishiyama, K. Shin-ya, T. Kuzuyama
- Journal Title
  
  Org. Biomol. Chem. 7
  
  Pages: 1454-1460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] JBIR-52, a novel antimycin-like compound, from Streptomyces sp.ML55.2009
- Author(s)
  Ikuko Kozone, Jun-ya Ueda, Motoki Takagi, Kazuo Shin-ya.
- Journal Title
  
  J.Antibiot. 62(10)
  
  Pages: 593-595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] Macrocyclic hexaoxazoles as sequence- and mode-selective G-quadruplex binders2008
- Author(s)
  M. Tera, H. Ishizuka, M. Takagi, M. Suganuma, K. Shin-ya, K. Nagasawa
- Journal Title
  
  Angew. Chem. Int. Ed 47
  
  Pages: 5557-5560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability2008
- Author(s)
  Y. Wu, K. Shin-ya, R. M. Brosh, Jr.
- Journal Title
  
  Mol. Cell Biol. 28
  
  Pages: 4116-4128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] Studying telomere replication by Q-CO-FISH : the effect of telomestatin, a potent G-quadruplex ligand2008
- Author(s)
  N. Arnoult, K. Shin-ya, J. -A. Londono-Vallejo
- Journal Title
  
  Cytogenet. Genome Res. 122
  
  Pages: 229-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6.2008
- Author(s)
  Jun-ya Ueda, Shuhei Chijiwa, Motoki Takagi, Kazuo Shin-ya.
- Journal Title
  
  J.Antibiot. 61(12)
  
  Pages: 752-755
- NAID
  10024825100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] JBIR-26, a novel natural compound from Streptomyces sp. AK-AH76, regulates mammalian circadian clock.2008
- Author(s)
  Miho Izumikawa, Hideki Ukai, Motoki Takagi, Hiroki R. Ueda, Kazuo Shin-ya.
- Journal Title
  
  J.Antibiot. 61(12)
  
  Pages: 756-758
- NAID
  10024825110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] Efrapeptin J, a new down-regulator of the molecular chaperone GRP78 from a marine Tolypocladium sp.2008
- Author(s)
  Y. Hayakawa, Y. Hattori, T. Kawasaki, K. Kanoh, K. Adachi, Y. Shizuri, K. Shin-ya
- Journal Title
  
  J. Antibiot. 28
  
  Pages: 365-371
- NAID
  10021927947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] Macrocyclic hexaoxazoles as sequence-and mode-selective G-quadruplex binders.2008
- Author(s)
  Masayuki. Tera, Hiromichi Ishizuka, Motoki Takagi, Masami Suganuma, Kazuo Shin-ya, Kazuo Nagasawa.
- Journal Title
  
  Angew.Chem.Int.Ed. 47(30)
  
  Pages: 5557-5560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin2008
- Author(s)
  J. Matsuo, Y. Tsukumo, J. Sakurai, S. Tsukahara, H. -R. Park, K. Shin-ya, T. Watanabe, T. Tsuruo, A. Tomida
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 327-333
- NAID
  10025142654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS62008
- Author(s)
  J. Ueda, S. Chijiwa, M. Takagi, K. Shin-ya
- Journal Title
  
  J. Antibiot 61
  
  Pages: 725-755
- NAID
  10024825100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] JBIR-26, a novel natural compound from Streptomyces sp. AK-AH76, regulates mammalian circadian clock2008
- Author(s)
  M. Izumikawa, H. Ukai, M. Takagi, H. Ueda, K. Shin-ya
- Journal Title
  
  J. Antibiot 61
  
  Pages: 326-329
- NAID
  10024825110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] Efrapeptin J, a new down-regulator of the molecular chaperone GRP78 from a marine Tolypocladium sp2008
- Author(s)
  Hayakawa, Y., Hattori, Y., Kawasaki, T., Kanoh, K., Adachi, K., Shizuri, Y., Shin-ya, K.
- Journal Title
  
  J. Antibiot. 61
  
  Pages: 365-371
- NAID
  10021927947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390031
[Journal Article] Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells.2008
- Author(s)
  R. Betous, N. Puget, J. Selves, D. S. Biard, K. Shin-ya, K. M. Vasquez, C. Cazaux, J. -S. Hoffmann, et al.
- Journal Title
  
  Mol. Carcinog. 48
  
  Pages: 369-378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380070
[Journal Article] Relative and absolute configuration of versipelostatin, a down-regulator of molecular chaperone GRP78 expression2007
- Author(s)
  Park, H.-R., Chijiwa, S., Furihata, K., Hayakawa, Y., Shin-ya, K.
- Journal Title
  
  Org. Lett. 9
  
  Pages: 1457-1460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390031
[Journal Article] Burkholone, a new cytotoxic antibiotic against IGF-I dependent cells from Burkholderia sp2007
- Author(s)
  Mori, T., Yamashita, T., Furihata, K., Nagai, K., Suzuki, K., Hayakawa, Y., Shin-ya, K.
- Journal Title
  
  J. Antibiot. 60
  
  Pages: 713-716
- NAID
  10019972488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390031
[Journal Article] Structure of thioviridamide, a novel apoptosis inducer from Streptomyces olivoviridis2006
- Author(s)
  Hayakawa, Y., Sasaki, K., Nagai, K., Shin-ya, K., Furihata, K.
- Journal Title
  
  J. Antibiot. 59
  
  Pages: 6-10
- NAID
  10017147062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390031
[Journal Article] Thioviridamide, a novel apoptosis inducer in transformed cells from Streptomyces olivoviridis2006
- Author(s)
  Hayakawa, Y., Sasaki, K., Adachi, H., Furihata, K., Nagai, K., Shin-ya, K.
- Journal Title
  
  J. Antibiot. 59
  
  Pages: 1-5
- NAID
  10017147044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390031
[Journal Article] Novel antitumor and neuroprotective substances discovered by characteristic screenings based on specific molecular targets.2005
- Author(s)
  Kazuo Shin-ya
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry 69・5
  
  Pages: 867-872
- NAID
  130000030314
- Data Source
  KAKENHI-PROJECT-17390031
[Journal Article] Mevashuntin, a novel metabolite produced by inhibition of the mevalonate pathway in Streptomyces prunicolor2005
- Author(s)
  Shin-ya, K., Umeda, Y., Chijiwa, S., Furihata, K., Furihata, K., Hayakawa, Y., Seto, H.
- Journal Title
  
  Tetrahedron Lett. 46
  
  Pages: 1273-1276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390031
[Presentation] 巨大生合成遺伝子クラスターを応用した異種発現システムの開発2017
- Author(s)
  新家　一男
- Organizer
  「生合成リデザイン」第３回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-26221204
[Presentation] Heterologous expression of large biosynthetic gene clusters originated from actinomycetes and Pseudomonas2017
- Author(s)
  Kazuo Shin-ya
- Organizer
  U.S./Japan Seminar on Natural Product Biosynthesis Enzymology, Structural Biology, Drug Discovery, and Genome Mining
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221204
[Presentation] Application of advanced technology of natural product chemistry for drug discovery2017
- Author(s)
  Kazuo Shin-ya
- Organizer
  APAC DAEWG Events at Bio Japan 2017
- Invited
- Data Source
  KAKENHI-PROJECT-26221204
[Presentation] Continued Efforts to Discover New Drugs using Natural Resources2017
- Author(s)
  Kazuo Shin-ya
- Organizer
  日本製薬工業協会、第6回アジア製薬団体連携会議; Asia Partnership Conference of Pharmaceutical Associations (APAC), 創薬連携 (Drug Discovery Alliances；DA)
- Invited
- Data Source
  KAKENHI-PROJECT-26221204
[Presentation] Cloning and heterologous expression of bacterial secondary metabolites produced in actinomycetes and Pseudomonas hosts2017
- Author(s)
  Kazuo Shin-ya
- Organizer
  China/Japan Symposium on Natural Product Biosynthesis
- Invited
- Data Source
  KAKENHI-PROJECT-26221204
[Presentation] 世界最大級の天然物ライブラリーの大規模HTS への応用2013
- Author(s)
  新家一男
- Organizer
  第333回CBI 学会研究講演会
- Place of Presentation
  東京, 東京大学山上会館
- Year and Date
  2013-01-22
- Data Source
  KAKENHI-PROJECT-23380067
[Presentation] 世界最大の天然物ライブラリーを用いたハイスループットランダムスクリーニング2013
- Author(s)
  新家　一男
- Organizer
  第31回　日本ヒト細胞学会学術集会
- Place of Presentation
  埼玉県、所沢
- Invited
- Data Source
  KAKENHI-PROJECT-23380067
[Presentation] 世界最大級の天然物ライブラリーの大規模HTSへの応用2013
- Author(s)
  新家　一男
- Organizer
  第333回CBI学会研究講演会 (招待講演)
- Place of Presentation
  東京都、東京大学
- Invited
- Data Source
  KAKENHI-PROJECT-23380067
[Presentation] 世界最大の天然物ライブラリーを用いたハイスループットランダムスクリーニング2013
- Author(s)
  新家一男
- Organizer
  第31回日本ヒト細胞学会学術集会
- Place of Presentation
  埼玉県, 所沢市民文化センター
- Year and Date
  2013-08-10
- Data Source
  KAKENHI-PROJECT-23380067
[Presentation] 天然物のハイスループットランダムスクリーニングへの応用2012
- Author(s)
  新家一男
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  神奈川県、慶應義塾大学(招待講演)
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-23380067
[Presentation] 天然物のハイスル-プットランダムスクリーニングへの応用2012
- Author(s)
  新家一男
- Organizer
  日本化学会第92 春季年会
- Place of Presentation
  神奈川県, 慶應義塾大学キャンパス
- Year and Date
  2012-03-20
- Data Source
  KAKENHI-PROJECT-23380067
[Presentation] プロテアソーム形成を阻害する化合物JBIR-22に関する研究2010
- Author(s)
  泉川美穂、橋本絢子、広川貴次、杉本聡、加藤平、高木基樹、新家一男
- Organizer
  2010年日本農芸化学会総会
- Place of Presentation
  東京
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20380070
[Presentation] JBIR-23, a novel compound of microbial origin, induces cytotoxicity against malignant mesothelioma cells by tubulin polymerization and apoptosis2010
- Author(s)
  新家一男、村上秀樹、Hwang Ji-Hwan、関戸好孝、高木基樹
- Organizer
  8th AACR-JCA Joint meeting
- Place of Presentation
  Waikoloa, Hawaii
- Year and Date
  2010-02-09
- Data Source
  KAKENHI-PROJECT-20380070
[Presentation] 新規GRP78発現抑制物質JBIR-52に関する研究2010
- Author(s)
  小曽根郁子、上田純也、高木基樹、新家一男
- Organizer
  2010年日本農芸化学会総会
- Place of Presentation
  東京
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20380070
[Presentation] JBIR-23, a novel compound of microbial origin, induces cytotoxicity against malignant mesothelioma cells by tubulin polymerization and apoptosis2010
- Author(s)
  高木基樹、村上秀樹、Hwang Ji-Hwan、関戸好孝、新家一男
- Organizer
  AACR Cell Death Mechanisms and Cancer Therapy
- Place of Presentation
  San Diego
- Year and Date
  2010-02-03
- Data Source
  KAKENHI-PROJECT-20380070
[Presentation] 海綿由来の放線菌より単離した新規anthracycline2010
- Author(s)
  本橋慶一郎、高木基樹、新家一男
- Organizer
  2010年日本農芸化学会総会
- Place of Presentation
  東京
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20380070
[Presentation] 新規化合物JBIR-23の中皮腫細胞に対する殺細胞活性発現メカニズムに関する報告2009
- Author(s)
  J. -H. Hwang, 本橋慶一郎, 関戸好孝, 高木基樹, 新家一男
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20380070
[Presentation] 新規抗酸化化合物JBIR-12に関する研究2009
- Author(s)
  泉川美穂, 永井文, 土井隆行, 高木基樹, 新家一男
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20380070
[Presentation] 新規化合物JBIR-23の中皮腫細胞に対する殺細胞活性発現メカニズムに関する報告2009
- Author(s)
  Hwang Ji-Hwan、本橋慶一郎、関戸好孝、高木基樹、新家一男
- Organizer
  2009年日本農芸化学会総会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20380070
[Presentation] 中皮腫細胞に対して抗癌活性を示す化合物のスクリーニング2009
- Author(s)
  本橋慶一郎, J. -H. Hwang, 関戸好孝, 高木基樹, 新家一男
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20380070
[Presentation] 新種のStreptomyces属から単離された新規化合物に関する研究2009
- Author(s)
  本橋慶一郎、Tabrez Shams Khan、小牧久幸、小曽根育子、向井啓、高木基樹、新家一男
- Organizer
  天然有機化合物討論会
- Place of Presentation
  名古屋
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-20380070
[Presentation] 中皮腫細胞に対して抗がん活性を示す化合物のスクリーニング2009
- Author(s)
  本橋慶一郎、Hwang Ji-Hwan、関戸好孝、高木基樹、新家一男
- Organizer
  2009年日本農芸化学会総会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20380070
[Presentation] アデノウィルス癌遺伝子導入細胞に対して選択的アポトーシスを誘導するthioviridamideの研究2006
- Author(s)
  早川洋一、佐々木佳穂里、足立久、新家一男、降旗一夫、永井浩二
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-17390031
[Presentation] 世界最大級の天然物ライブラリーを用いたハイスループットランダムスクリーニング
- Author(s)
  新家　一男
- Organizer
  第２０回天然薬物の開発と応用シンポジウム薬学セミナー
- Place of Presentation
  東京都文京区（東京大学弥生講堂一条ホール）
- Year and Date
  2014-11-05 – 2014-11-06
- Invited
- Data Source
  KAKENHI-PROJECT-26221204
[Presentation] 放線菌二次代謝産物異種発現生産の大規模検証
- Author(s)
  新家　一男
- Organizer
  生物工学会第66回大会　シンポジウム「天然物生合成研究の最前線」
- Place of Presentation
  北海道札幌市白石区（札幌コンベンションセンター）
- Year and Date
  2014-09-09 – 2014-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-26221204

1. HAYAKAWA Yoichi (20208606)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. SETO Haruo (10013335)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. FURIHATA Kazuo (20219091)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KAWASAKI Takashi (00408733)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. KUZUYAMA Tomohisa (30280952)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 末永光 (90357252)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. FURIHATA Keiko

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 渡邉秀典 (00202416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 石神健 (70292787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 吉田稔 (80191617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 中尾洋一 (60282696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 工藤慧 (80828161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. FUJITA Ken-ich

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HIGUCHI Keiichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 降旗圭子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KOMATSU Mamoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 池田治生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 平尾敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 大田久美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 増田裕一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shinya Kazuo 新家 一男

SHIN-YA Kazuo 新家 一男

Research Projects

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Co-Researchers

メタゲノミクスによる海綿における天然有機化合物生産機構の解明Ongoing

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Fermentative production of rare natural compounds found in marine organisms living in the seas of ThailandPrincipal InvestigatorOngoing

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Development of novel methods for target identification of natural products and chemical epigeneticsOngoing

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Studies on screening for substances which act on cancer stem cells established from tumors surgically excised from brain tumor patients.Principal Investigator

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Studies on screening for bioactive compounds targeting gene repair, recombination and splicing systems.Principal Investigator

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Screening for microbial metabolites that regulate cellular stress response

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グルタミン酸毒性の発現・抑制機講解明を指向したカイトセファリンの合成と応用研究

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微生物由来のテロメラーゼ阻害物質telomestatinに関する研究Principal Investigator

Principal Investigator

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Review Section

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BIAcoreを用いた標識化低分子化合物をプローブとした複合タンパク質の探索研究

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Studies on apoptosis regulators substances of microbial origin aiming at neuroprotectionPrincipal Investigator

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Biosynthetic studies on terpenoids produced by Actinomycetes by focusing on the nonmevalonate pathway

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Studies on substances of microbial origin which protect central nervous systemPrincipal Investigator

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微生物の生産する脳中枢神経細胞保護物質に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Shinya Kazuo 新家一男

SHIN-YA Kazuo 新家一男