KAKAZU Naoki 嘉数直樹

… Alternative Names

Researcher Number	20264757
Other IDs
External Links
Affiliation (Current)	2019: 九州工業大学, 保健センター, 教授
Affiliation (based on the past Project Information) *help	2018: 島根大学, 医学部, 准教授 2007 – 2014: Shimane University, Shimane University School of Medicine, Associate Professor 2006: 島根大学, 医学部, 助教授 2004 – 2005: 京都府立医科大学, 医学研究科, 助手 1999 – 2003: 京都府立医科大学, 医学部, 助手 1994 – 1996: 京都府立医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Hematology / Biological Sciences / Experimental pathology / Human genetics / Human pathology / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Hematology / Experimental pathology Except Principal Investigator Hygiene / Hematology / Pathological medical chemistry
Keywords	Principal Investigator SKY法 / 染色体解析 / 融合遺伝子 / cytogenetic analysis / 染色体カラーバンディング法 / 造血器腫瘍 / SCAN法 / Gバンド法 / 悪性中皮腫 / SKY … More Except Principal Investigator FISH / メタボリックシンドローム / CGH / Stat / 肥満 / 糖尿病 / 身体活動 / γδT細胞 / ヒストンアセチル化 / Fond / hematopoietic stem cell / 生活習慣 / 異種間移植 / 炭水化物 / 遺伝子診断 / SKY / γδ T cell / Genetic polymorphism / サイトカイン / histone modification / 胃がん / 疫学 / T cell antigen receptor / 造血幹細胞 / クロマチン / 遺伝子多型 / Metabolic syndrome / 転写共役因子 / Exercise / multiclor-banding / MDS / Diabetes / 日本 / chromatin / cytokine / 前糖尿病 / 介入 / サイトカインレセプター / 発症要因 / flow cytometry / 悪性リンパ腫 / 染色体異常 / シグナル伝達 / T細胞抗原受容体 / ヒストン修飾 / Obesity / 中国 / DNA recombination / 遺伝子増幅 / フローサイトメトリー / 耐糖能異常 / signal transduction / Carbohydrate / 遺伝 / がん / DNA組換え / サイトカインレセプタ / dual karyotyping / FISH法 / xenotransplantation / 食生活 Less

石綿関連悪性中皮腫の次世代シークエンスで同定した融合遺伝子の発癌・治療標的性解析Principal InvestigatorOngoing
- Principal Investigator
  
  嘉数直樹
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Shimane University
Identification of novel causative genes in mesothelioma and the elucidation of the carcinogenic mechanismPrincipal Investigator
- Principal Investigator
  
  KAKAZU Naoki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Shimane University
Identification of a novel chimera gene not involving PAX family gene in rhabdomyosarcoma cell linesPrincipal Investigator
- Principal Investigator
  
  KAKAZU Naoki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Shimane University
Predictive study for metabolic syndrome and prediabetes
- Principal Investigator
  
  SHIWAKU Kuninori
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Shimane University
The identification of the novel causative genes in embryonal rhabdomyosarcoma and the elucidation of the molecular mechanismPrincipal Investigator
- Principal Investigator
  
  KAKAZU Naoki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Shimane University
Interaction between genetic and environmental factors in metabolic syndrome
- Principal Investigator
  
  SHIWAKU Kuninori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Shimane University
The study of the molecular mechanism underlying leukemogenesis caused by the translocation involving a novel polycomb-group gene, ASXH2Principal Investigator
- Principal Investigator
  
  KAKAZU Naoki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto Prefectural University of Medicine
A challenge for long-term human lymphohemopoietic reconstitution in mice with normal immunity
- Principal Investigator
  
  KIMURA Takafumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto Prefectural University of Medicine
ゲノム資源を活用した新規間期核FISH法の開発と癌ゲノム異常の包括的解析への応用Principal Investigator
- Principal Investigator
  
  嘉数直樹
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Prefectural University of Medicine
Recombination control of lymphocyte antigen receptor loci by chromati modification
- Principal Investigator
  
  IKUTA Koichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University
Spectral color banding(SCAN)法によるゲノム構造の解析Principal Investigator
- Principal Investigator
  
  嘉数直樹
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Prefectural University of Medicine
Development of automated karyotyping that allows for accurate identification of the origin of chromosome bands and subtelomeres.Principal Investigator
- Principal Investigator
  
  KAKAZU Naoki, 阿部達生
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human genetics
- Research Institution
  Kyoto Prefectural University of Medicine
造血器腫瘍および固形がんにおける遺伝子異常の解析とその診断への応用
- Principal Investigator
  
  ABE Tatsuo
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto Prefectural University of Medicine
Development of new spectral karyotyping (SKY) techniques in cytogenetic analysisPrincipal Investigator
- Principal Investigator
  
  KAKAZU Naoki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto Prefectural University of Medicine
FISH法による癌悪性度判定法の開発
- Principal Investigator
  
  稲澤譲治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
DNA fiber FISH法による造血器腫瘍における融合遺伝子の検出Principal Investigator
- Principal Investigator
  
  嘉数直樹
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Kyoto Prefectural University of Medicine
骨髄異形成症候群に検出した11q23転座切断点の単離Principal Investigator
- Principal Investigator
  
  嘉数直樹
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2014 2010 2009 2007 2006 Other

All Journal Article Presentation

[Journal Article] Identification of the 12q15 Amplicon within the Homogeneously Staining Regions in the Embryonal Rhabdomyosarcoma Cell Line RMS-YM2014
- Author(s)
  Kakazu N, Yamane H, Miyachi M, Shiwaku K, Hosoi H
- Journal Title
  
  Cytogenet Genome Res
  
  Volume: 142 Pages: 167-173
- DOI
  10.1159/000357930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590464
[Journal Article] PAX3-NCOA2 fusion gene has a dual role in promoting the proliferation and inhibiting the myogenic differentiation of rhabdomyosarcoma cells.2014
- Author(s)
  Yoshida H, Miyachi M, Sakamoto K, Ouchi K, Yagyu S, Kikuchi K, Kuwahara Y, Tsuchiya K, Imamura T, Iehara T, Kakazu N, Hojo H, Hosoi H.
- Journal Title
  
  Oncogene.
  
  Volume: in press Pages: 5601-8
- DOI
  10.1038/onc.2013.491
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590464, KAKENHI-PROJECT-25253095, KAKENHI-PROJECT-21249085, KAKENHI-PROJECT-24659500, KAKENHI-PROJECT-24791078
[Journal Article] Chromosomal manipulation by site-specific recombinases and fluorescent protein-based vectors.2010
- Author(s)
  Uemura M, Niwa Y, Kakazu N, Adachi N, Kinoshita K.
- Journal Title
  
  PLoS One 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590365
[Journal Article] Restoration of p53 pathway by Nutlin-3 induces cell cycle arrest and apoptosis in human rhabdomyosarcoma cells2009
- Author(s)
  Miyachi M, Kakazu N, Yagyu S, Katsumi Y, Tsubai-Shimizu S, Kikuchi K, Tsuchiya K, Iehara T, Hosoi H.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 15 Pages: 4077-4084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590365
[Journal Article] Restoration of p53 pathway by nutlin-3 induces cell cycle arrest and apoptosis in human rhabdomyosarcoma cells.2009
- Author(s)
  Miyachi M, Kakazu N, et al.
- Journal Title
  
  Clin Cancer Res 15
  
  Pages: 4077-4084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590365
[Journal Article] The chromosomal constitution of postmitotic neurons, assessed by neuronal nuclear transfer into oocytes and in ES cell lines derived from them.2009
- Author(s)
  Osada T, Kakazu N, et al.
- Journal Title
  
  Cytogenet Genome Res 125
  
  Pages: 201-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590365
[Journal Article] A novel PAX3 rearrangement in embryonal rhabdomyosarcoma2009
- Author(s)
  Hosoi H, Kakazu N, et al.
- Journal Title
  
  Cancer Genet Cytogenet 189
  
  Pages: 98-104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590365
[Journal Article] Clinical features of hypereosinophilic syndrome (HES): FIP1L1-PDGFRA fusion gene positive-HES is a distinct clinical entity with myeloproliferative features and a poor response to corticosteroid2007
- Author(s)
  Miyazawa K, Kakazu N, et. al.
- Journal Title
  
  Int J Hematol 85
  
  Pages: 5-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590378
[Journal Article] AID promotes B cell lymphomagenesis in Emu-cmyc transgenic mice2007
- Author(s)
  Kotani A, Kakazu N, et. al.
- Journal Title
  
  Proc Nat1 Acad Sci USA 104
  
  Pages: 1616-1620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590378
[Journal Article] Multicolor banding technique, spectral color banding (SCAN) : new development and applications.2006
- Author(s)
  Kakazu N
- Journal Title
  
  Cytogenet Genome Res 114
  
  Pages: 250-256
- Data Source
  KAKENHI-PROJECT-18590378
[Journal Article] Multicolor banding technique, spectral color banding (SCAN) : new development and applications2006
- Author(s)
  Kakazu N, et al.
- Journal Title
  
  Cytogenet Genome Res 114
  
  Pages: 250-256
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590378
[Journal Article] Multicolor banding technique, spectral color banding (SCAN): new development and applications2006
- Author(s)
  Kakazu N, et al.
- Journal Title
  
  Cytogenet Genome Res 114
  
  Pages: 250-256
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590378
[Journal Article] Multicolor Banding Technique, Spectral Color Banding (SCAN) : New Development and Applications
- Author(s)
  Kakazu N
- Journal Title
  
  Cytogenet Genome Res (in press)
- Data Source
  KAKENHI-PROJECT-16590956
[Journal Article] Multicolor banding technique, spectral color banding (SCAN) : new development and applications
- Author(s)
  Kakazu N, et al.
- Journal Title
  
  Cytogenet Genome Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590956
[Journal Article] Multicolor Banding Technique, Spectral Color Banding (SCAN): New Development and Applications
- Author(s)
  Kakazu N
- Journal Title
  
  Cytogenet Genome Res (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590956
[Presentation] 健康教育介入によるメタボリックシンドロームの改善2007
- Author(s)
  渡部麻実子, 山崎雅之, 嘉数直樹, 塩飽邦憲
- Organizer
  第80日本産業衛生学会
- Place of Presentation
  大阪
- Year and Date
  2007-04-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590557
[Presentation] 次世代シークエンサーによる悪性中皮腫における融合転写産物の網羅的同定
- Author(s)
  嘉数直樹、山根史嗣
- Organizer
  日本衛生学会学術総会
- Place of Presentation
  ホテルアバローム紀の国（和歌山市）
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-23590464

1. ABE Tatsuo (60079746)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. SHIWAKU Kuninori (10108384)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. YAMASAKI Masayuki (60379683)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. IWAMOTO Mamiko (90432616)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 稲澤譲治 (30193551)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. IKUTA Koichi (90193177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KIMURA Takafumi (30275193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SONODA Yoshiaki (60206688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IKEHARA Susumu (90108986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NOGI Akiko (90312305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 三澤信一 (40117908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 阪倉長平 (10285257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 谷脇雅史 (80163640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YE Sang-kyu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HOSOI Hajime

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 北條洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 家原知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 土屋邦彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 宮地充

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAKAZU Naoki 嘉数 直樹

嘉数 直樹 カカズ ナオキ

Research Projects

Research Products

Co-Researchers

石綿関連悪性中皮腫の次世代シークエンスで同定した融合遺伝子の発癌・治療標的性解析Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel causative genes in mesothelioma and the elucidation of the carcinogenic mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of a novel chimera gene not involving PAX family gene in rhabdomyosarcoma cell linesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Predictive study for metabolic syndrome and prediabetes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The identification of the novel causative genes in embryonal rhabdomyosarcoma and the elucidation of the molecular mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interaction between genetic and environmental factors in metabolic syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of the molecular mechanism underlying leukemogenesis caused by the translocation involving a novel polycomb-group gene, ASXH2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A challenge for long-term human lymphohemopoietic reconstitution in mice with normal immunity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ゲノム資源を活用した新規間期核FISH法の開発と癌ゲノム異常の包括的解析への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Recombination control of lymphocyte antigen receptor loci by chromati modification

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Spectral color banding(SCAN)法によるゲノム構造の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of automated karyotyping that allows for accurate identification of the origin of chromosome bands and subtelomeres.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

造血器腫瘍および固形がんにおける遺伝子異常の解析とその診断への応用

Principal Investigator

Project Period (FY)

KAKAZU Naoki 嘉数直樹

嘉数直樹カカズナオキ