Yui Naoko 油井直子

… Alternative Names

YUI NAOKO 油井直子

油井直子ユイナオコ

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Researcher Number	20266696
Affiliation (Current)	2025: 聖マリアンナ医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2015 – 2023: 聖マリアンナ医科大学, 医学部, 講師 2012 – 2014: 聖マリアンナ医科大学, 医学部, 助教 1999 – 2000: 東京慈恵会医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 59020:Sports sciences-related / Orthopaedic surgery / Orthopaedic surgery Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator 軟骨細胞 / 変形性関節症 / メカニカルストレス / 半月板細胞 / 核酸修復酵素 / 半月細胞 / 細胞エネルギー代謝 / 酸化ストレス / 細胞老化 / 核酸修復 … More / 機械的ストレス / 核酸損傷 / 力学的ルストレス / 軟骨変性 / mechanical stress / meniscus cell / chondrocyte / DNA repair enzyme / ＡＰＥＸ２ / 変性 / DNA修復酵素 / ＤＮＡ修復酵素 / 生化学的分析 / Collagen / 足関節 … More Except Principal Investigator 細胞エネルギー代謝 / メカニカルストレス / 軟骨変性 / 核酸損傷修復酵素 / 核酸修復酵素 / 軟骨細胞 / 変形性関節症 / ストレス応答蛋白 / NAD依存性脱アセチル化酵素活性 / ストレス応答能 / エネルギー代謝 / 軟骨代謝 / 活性酸素種 / DNA修復酵素 / ATPエネルギー / 酸化ストレス Less

力学的ストレスに応答する軟骨・半月細胞の核酸修復とエネルギー代謝の相関、治療応用Principal Investigator
- Principal Investigator
  
  油井直子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  St. Marianna University School of Medicine
Mechanical stress regulates the DNA repair and energy metabolism in chondrocytes and meniscus cells.Principal Investigator
- Principal Investigator
  
  Yui Naoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  St. Marianna University School of Medicine
Mechanical stress regulates the chondrocyte activity through the cellular energy metabolism in osteoarthritis.
- Principal Investigator
  
  Yudo Kazuo
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  St. Marianna University School of Medicine
Mechanical stress regulates the DNA repair enzymes in chondrocytes and meniscus cells.Principal Investigator
- Principal Investigator
  
  Naoko Yui
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  St. Marianna University School of Medicine
Role of chondrocyte DNA repair enzymes in the degeneration of articular cartilage in osteoarthritis.
- Principal Investigator
  
  YUDO KAZUO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  St. Marianna University School of Medicine
The analysis between degeneration of chondrocytes in Osteoarthritis and DNA repair enzyme APEX2.Principal Investigator
- Principal Investigator
  
  YUI NAOKO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  St. Marianna University School of Medicine
ヒト足関節周囲の腱、靭帯におけるコラーゲン分析Principal Investigator
- Principal Investigator
  
  油井直子
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Jikei University School of Medicine

All 2021 2019 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] Sirtuin in bone and cartilage biology, SIRTUIN BIOLOGY IN MEDICINE2021
- Author(s)
  Kazuo Yudoh, Naoko Yui, Ko Terauchi, Hajime Kobayashi, Takanori Kumai, Shu Somemura.
- Publisher
  Academic press
- Data Source
  KAKENHI-PROJECT-17K11035
[Journal Article] A novel, self-assembled artificial cartilage and hydroxyapatite conjugate for combined articular cartilage and subchondral bone repair: histopathological analysis of cartilage tissue engineering in rat knee joints.2019
- Author(s)
  Kumai Takanori、Yui Naoko、Yatabe Kanaka、Sasaki Chizuko、Fujii Ryoji、Takenaga Mitsuko、Fujiya Hiroto、Niki Hisateru、Yudoh Kazuo
- Journal Title
  
  International Journal of Nanomedicine
  
  Volume: Volume 14 Pages: 1283-1298
- DOI
  10.2147/ijn.s193963
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11035, KAKENHI-PROJECT-16K10922
[Journal Article] Cartilage Tissue Engineering-A Novel Biomaterial for Cartilage Repair Generated by Self- Assembly: Creation of a Self-Organized Articular Cartilage-like Tissue.2017
- Author(s)
  Yudoh K, Kumai T, Fujiya H, Yui N, Karasawa R.
- Journal Title
  
  Novel Techniques in Arthritis & Bone Research
  
  Volume: 1（2） Pages: 1-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11035
[Journal Article] The Nicotinamide Adenine Dinucleotide (NAD)-Dependent Deacetylase Sirtuin-1 Regulates Chondrocyte Energy Metabolism through the Modulation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) in Osteoarthritis (OA).2017
- Author(s)
  Kobayashi H, Terauchi K, Yui N, Yatabe K, Kamada T, Fujiya H, Niki H, Musha H, Yudoh K.
- Journal Title
  
  Journal of Arthritis
  
  Volume: 6（238）
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11035
[Journal Article] Cell-to-Cell Interactions of Activated T Cells with Adjacent Cells in Inflamed Tissue in Inflammatory Diseases.2017
- Author(s)
  Yudoh K, Yui N, Kumai T, Karasawa R.
- Journal Title
  
  Novel Techniques in Arthritis & Bone Research
  
  Volume: 2（3） Pages: 1-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11035
[Journal Article] Therapeutic Potential of Nanocarbon C60 Fullerene in Osteoarthritis.2017
- Author(s)
  Yudoh K, Yoshioka H, Yui N, Karasawa R.
- Journal Title
  
  International Journal of Development Research
  
  Volume: 7（４） Pages: 12450-12453
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11035
[Journal Article] Mechanical stress and oxidative stress in osteoarthritis.2016
- Author(s)
  Naoko Yui, Haruki Musha, Kazuo Yudoh
- Journal Title
  
  Journal of Physical Fitness and Sports Medicine
  
  Volume: 5 Pages: 81-86
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462323
[Journal Article] The NAD-Dependent deacetylase sirtuin-1 regulates the expression of osteogenic transcriptional activator runt-related transcription factor 2 (Runx2) and production of matrix metalloproteinase (MMP)-13 in chondrocytes in osteoarthritis.2016
- Author(s)
  Terauchi K, Kobayashi H, Yatabe K, Yui N, Fujiya H, Niki H, Musha H, Yudoh K (Corresponding author).
- Journal Title
  
  Int. J Molecular Science.
  
  Volume: 1019 Pages: 1033-1033
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462323
[Journal Article] Polyhydroxylated C60 fullerenes prevent chondrocyte catabolic activity at the concentration of nanomolar order in osteoarthritis.2016
- Author(s)
  Yoshioka H, Yui N, Fujiya H, Musha H, Niki H, Karasawa R, Yudoh K (Corresponding author).
- Journal Title
  
  International Journal of Clinical Rheumatology
  
  Volume: 11(5) Pages: 70-76
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462323
[Journal Article] The DNA Repair Enzyme Apurinic/Apyrimidinic Endonuclease (Apex Nuclease) 2 Has the Potential to Protect against Down-Regulation of Chondrocyte Activity in Osteoarthritis2014
- Author(s)
  油井直子
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 15 Issue: 9 Pages: 14921-14934
- DOI
  10.3390/ijms150914921
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592286, KAKENHI-PROJECT-26462323
[Journal Article] Water-Soluble C60-(OH)24 Fullerene Hydroxide Protects against the Catabolic Stress-Induce Downregulation of Chondrocyte Activity in Osteoarthritis.2014
- Author(s)
  Yoshioka H, Yui N, Fujiya H, Musha H, Beppu M, Karasawa R, Yudoh K.
- Journal Title
  
  J Nanotech Smart Mater
  
  Volume: １（４０１） Pages: 1-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462323
[Presentation] 三次元培養下における骨芽細胞および破骨細胞の力学的ストレス応答能の解析2019
- Author(s)
  熊井隆智, 遊道和雄, 小谷貴史, 谷田部かなか, 油井直子, 仁木久照, 藤谷博人
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K11035
[Presentation] NAD依存性脱アセチル化酵素Sirtuin1と骨形成転写因子Runx2の変性軟骨細胞における役割2016
- Author(s)
  寺内昂, 遊道和雄, 小林創, 油井直子, 藤谷博人, 仁木久照, 武者春樹.
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡県福岡市福岡国際会議場
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26462323
[Presentation] The Role of ATP-Activeted Protein Kinase(AMPK) in the Chondrocyte Energy Balance and IL-β-induced Production of MMP-13 in Osteoarthritis(OA).2016
- Author(s)
  Yui N, Musha H, Fujiya H, Yatabe K, Yoshioka H, Terauchi K, Yudoh K.
- Organizer
  OARSI 2016 World Congress
- Place of Presentation
  RAIコンベンションセンター　アムステルダム（オランダ王国）
- Year and Date
  2016-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462323
[Presentation] 変形性関節症の軟骨細胞におけるエネルギー代謝とSirtuin1との関連について.2016
- Author(s)
  小林創, 油井直子, 寺内昂, 藤谷博人, 遊道和雄, 仁木久照, 武者春樹.
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡県福岡市福岡国際会議場
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26462323
[Presentation] Significance of defence mechanism for oxidative DNA damages in osteoarthritis: DNA repair enzyme, apurinic/apyrimidinic endonuclease (APEX"), protects against the catabolysis of articular cartilage in OA.2015
- Author(s)
  Yui N, Musha H, Fujiya H, Yatabe K, Yoshioka H, Terauchi K, Yudoh K.
- Organizer
  15th International Conference on ISANH Antioxidants
- Place of Presentation
  Paris, France
- Year and Date
  2015-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462323
[Presentation] Water-soluble C60－【OH)24 fullerene hydroxide as a therapeutic agent in the degeneration of articular cartilage in osteoarthritis.2015
- Author(s)
  Yui N, Yoshioka H, Fujiya H, Musha H, Karasawa R, Yudoh K.
- Organizer
  World congress on Osteoarthritis 2015.
- Place of Presentation
  Seattle, USA.
- Year and Date
  2015-04-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462323
[Presentation] DNA REPAIR ENZYME, APURINIC/APYRIMIDINIC ENDONUCLEASE 2 (APEX2), HAS A POTENTIAL TO PROTECT AGAINST THE DOWN-REGULATION OF CONDROCYTE ACTIVITY IN OSTEOARTHRITIS.
- Author(s)
  Yui N, Yoshioka H, Karasawa R, Yudoh K.
- Organizer
  2014 World Congress on Osteoarthritis.
- Place of Presentation
  Paris, France
- Year and Date
  2014-04-24 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-26462323
[Presentation] DNA repair enzyme Apurinic/Apyrimidinic Endonuclease 2 (APEX2) has a potential to protect against the down-regulation of chondrocyte activity in osteoarthritis
- Author(s)
  油井直子
- Organizer
  国際変形性関節症学会 (OARSI 2014)
- Place of Presentation
  The Center of New Industries and Technologies （フランス・パリ）
- Year and Date
  2014-04-24 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24592286

1. YUDOH Kazuo (60272928)

# of Collaborated Projects: 6 results

# of Collaborated Products: 17 results
2. 唐澤里江 (50434410)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KARASAWA Rie (50424410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results

Yui Naoko 油井 直子

YUI NAOKO 油井 直子

油井 直子 ユイ ナオコ

Research Projects

Research Products

Co-Researchers

力学的ストレスに応答する軟骨・半月細胞の核酸修復とエネルギー代謝の相関、治療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanical stress regulates the DNA repair and energy metabolism in chondrocytes and meniscus cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanical stress regulates the chondrocyte activity through the cellular energy metabolism in osteoarthritis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanical stress regulates the DNA repair enzymes in chondrocytes and meniscus cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of chondrocyte DNA repair enzymes in the degeneration of articular cartilage in osteoarthritis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis between degeneration of chondrocytes in Osteoarthritis and DNA repair enzyme APEX2.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト足関節周囲の腱、靭帯におけるコラーゲン分析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Sirtuin in bone and cartilage biology, SIRTUIN BIOLOGY IN MEDICINE2021

Author(s)

Publisher

Data Source

[Journal Article] A novel, self-assembled artificial cartilage and hydroxyapatite conjugate for combined articular cartilage and subchondral bone repair: histopathological analysis of cartilage tissue engineering in rat knee joints.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cartilage Tissue Engineering-A Novel Biomaterial for Cartilage Repair Generated by Self- Assembly: Creation of a Self-Organized Articular Cartilage-like Tissue.2017

Author(s)

Journal Title

Data Source

[Journal Article] The Nicotinamide Adenine Dinucleotide (NAD)-Dependent Deacetylase Sirtuin-1 Regulates Chondrocyte Energy Metabolism through the Modulation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) in Osteoarthritis (OA).2017

Author(s)

Journal Title

Data Source

[Journal Article] Cell-to-Cell Interactions of Activated T Cells with Adjacent Cells in Inflamed Tissue in Inflammatory Diseases.2017

Author(s)

Journal Title

Data Source

[Journal Article] Therapeutic Potential of Nanocarbon C60 Fullerene in Osteoarthritis.2017

Author(s)

Journal Title

Data Source

[Journal Article] Mechanical stress and oxidative stress in osteoarthritis.2016

Author(s)

Journal Title

Data Source

[Journal Article] The NAD-Dependent deacetylase sirtuin-1 regulates the expression of osteogenic transcriptional activator runt-related transcription factor 2 (Runx2) and production of matrix metalloproteinase (MMP)-13 in chondrocytes in osteoarthritis.2016

Author(s)

Journal Title

Yui Naoko 油井直子

YUI NAOKO 油井直子

油井直子ユイナオコ