OZONO Keiichi 大薗恵一

… Alternative Names

Researcher Number	20270770
Other IDs
External Links
Affiliation (Current)	2019: 大阪大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 大阪大学, 医学系研究科, 教授 2013 – 2014: 大阪大学, 医学(系)研究科(研究院), 教授 2002 – 2012: Osaka University Graduate School of Medicine, Department of Pediatrics, Professor, 医学系研究科, 教授 2011: 大阪大学, 医学系・研究科, 教授 2003: Osaka University Graduate School Medicine, Department of Pediatrics, Professor, 大学院・医学研究科・生体統合医学・小児発達医学, 教授 … More
Review Section/Research Field	Principal Investigator Pediatrics / Kidney internal medicine / 内分泌・代謝学 / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Pediatrics / Pediatrics / Orthodontics/Pediatric dentistry
Keywords	Principal Investigator ビタミンD / 骨系統疾患 / transgenic mouse / ビタミンD応答配列 / 骨粗鬆症 / SHOX / vitamin D / ビタミンD受容体 / メガリン / PTPN11遺伝子 … More Except Principal Investigator 肝線維化 / IL-6 / TGF-β / 遺伝子治療 / osteoprotegerin / RANKL / pQCT / Lrp6 / Grb10 / VDR / ステロイド・ホルモン / cAMP / 核内受容体 / PTHrP / Gsα protein / 乳歯の早期脱落 / 催奇性薬剤 / 偽胆管 / 骨形成不全症 / Wntシグナル / bone metastasis / 肝細胞障害 / spina bifida / チロシンキナーゼ型受容体 / Peptide / cyclic AMP / 乳癌 / スクリーニング / 初代培養肝細胞 / Hepatocyte damage / 筋肉内遺伝子導入 / 低ホスファターゼ症 / primary culture of hepatocytes / Hepatic fibrosis / Pagets disease / 遺伝子転写 / レチノイド / osteoclast / McCune-Albright syndrome / ビタミンD / Jagged1遺伝子 / 酵素補充療法 / Liver fibrosis / 骨転移 / 神経芽細胞腫 / 胆管上皮細胞 / Wnt signaling / fibrous dysplasia / gene therapy / McCune-Albright症候群 / 肝星細胞 / 共役因子 / Gsαタンパク変異 / 肝硬変 / TGFβ / hepatic fibrosis / bile duct epithelial cell / ビタミンD受容体 / 核受容体 / セメント質形成不全 / 破骨細胞 / ER / 葉酸 / 白血病 / 骨系統疾患 / 象牙質形成不全 / 二分脊椎 / Gsalpha mutation / 前立腺癌 / AR / Tyrosine kinase type receptor / neuroblastoma / Jagged 1 gene / ペプチド / SH2ドメイン / Hepatic stellate cell Less

Analysis of mechanism of bone fragility and effects of drugs in osteogenesis imperfecta using a graft model for enchondral bone formationPrincipal InvestigatorOngoing
- Principal Investigator
  
  大薗恵一
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka University
Basic and clinical approaches for dental problems associated with skeletal diseases
- Principal Investigator
  
  OKAWA RENA
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Osaka University
Ozono KeiichiPrincipal Investigator
- Principal Investigator
  
  OZONO Keiichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Role of FGF23 in metabolic bone diseasesPrincipal Investigator
- Principal Investigator
  
  OZONO Keiichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
The effect of calcitropic hormone on bone forming action of・-cateninsignalPrincipal Investigator
- Principal Investigator
  
  OZONO Keiichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Molecular biological assessment of hepatocyte damage and fibrosis in intractable pediatric liver diseases
- Principal Investigator
  
  MUSHIAKE Sotaro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Study for the development of screening method for the teratogenic medicine using spina bifida model mice
- Principal Investigator
  
  SAKAI Norio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Analysis of height-determining gene.Principal Investigator
- Principal Investigator
  
  OZONO Keiichi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
A Study for Clinical Application of TGP-β Activation-Inhibitory Peptide "LSKL" for Progressive Liver Damage
- Principal Investigator
  
  MUSHIAKE Sotaro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Development of Organ-specific Treatment for Bone Metastasis in Neuroblastoma
- Principal Investigator
  
  MICHIGAMI Toshimi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka Medical Center and Research Institute for Maternal and Child Health
Functional analysis of megalin, a key molecule of reabsorption in renal tubular cells ; making and using RAP-transgenic micePrincipal Investigator
- Principal Investigator
  
  OZONO Keiichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Osaka University
  Research Institute, Osaka Medical Center for Maternal and Child Health
Characterization of the expression of 1 alpha-hydroxylase in kidney and application to renal failurePrincipal Investigator
- Principal Investigator
  
  OZONO Keiichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Research Institute, Osaka Medical Center for Maternal and Child Health
ホルモンによるがん増殖制御機構とその臨床応用
- Principal Investigator
  
  尾形悦郎
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Japanese Foundation For Cancer Research
A Study of Expression and Function of Jagged 1 Gene Relating the Development of Intrahepatic Bile Ducts and Bile Ductule Proliferation in Hepatic Fibrosis.
- Principal Investigator
  
  TAJIRI Hitoshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
ビタミンD応答配列(VDRE)の解析 positive vs negative VDREPrincipal Investigator
- Principal Investigator
  
  大薗恵一
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Research Institute, Osaka Medical Center for Maternal and Child Health
ビタミンD受容体の遺伝子転写制御活性を有する部位の検討
- Principal Investigator
  
  NAKAJIMA Shigeo
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Research Institute, Osaka Medical Center for Maternal and Child Health
骨芽細胞におけるPTHrP産生とビタミンDによる調節Principal Investigator
- Principal Investigator
  
  大薗恵一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Research Institute, Osaka Medical Center for Maternal and Child Health
Gsalpha mutation and increased production of cAMP and IL-6 in patients with McCune-Albright syndrome.
- Principal Investigator
  
  SHIMA Masaaki, 山本威久
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University

All 2017 2016 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] 骨研究最前線　アンチ・エイジングシリーズ　No.3 代謝・疾患のメカニズムから再生医療・創薬・リハビリ機器・機能性食品開発まで2013
- Author(s)
  大薗恵一
- Publisher
  エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-24390264
[Book] ビタミンDと疾患　改訂版　-基礎の理解と臨床への応用-2013
- Author(s)
  大薗恵一
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-24390264
[Book] 今日の小児治療指今日の小児治療指針第15版2012
- Author(s)
  大薗恵一
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21591319
[Book] 小児腎臓病学2012
- Author(s)
  大薗恵一
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-21591319
[Book] 今日の治療指針私はこう治療している2012
- Author(s)
  大薗恵一
- Total Pages
  1188
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21591319
[Book] 今日の小児治療指針第15版2012
- Author(s)
  大薗恵一
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21591319
[Book] 骨粗鬆症診療ハンドブック改訂5版2012
- Author(s)
  大薗恵一
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-24390264
[Book] 小児科診療ガイドライン-最新の診療指針-第2版2011
- Author(s)
  大薗恵一
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-21591319
[Book] 今日の治療指針-私はこう治療している-くる病2008
- Author(s)
  大薗恵一
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19591204
[Book] 今日の治療指針-私はこう治療している-2008
- Author(s)
  大薗恵一
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19591204
[Book] 小児科学第3版8章先天代謝異常症, 代謝疾患Jくる病Rickets2008
- Author(s)
  大薗恵一
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19591204
[Book] 小児科学第3版 8章先天代謝異常症, 代謝疾患 J くる病 Rickets2008
- Author(s)
  大薗恵一
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19591204
[Book] 小児科診療ガイドライン-最新の診療指針-2007
- Author(s)
  大薗恵一
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-19591204
[Journal Article] Early exfoliation of permanent tooth in patient with hypophosphatasia2017
- Author(s)
  Okawa Rena、Miura Jiro、Kokomoto Kazuma、Kubota Takuo、Kitaoka Taichi、Ozono Keiichi、Nakano Kazuhiko
- Journal Title
  
  Pediatric Dental Journal
  
  Volume: 27 Pages: 173-178
- DOI
  10.1016/j.pdj.2017.08.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11364
[Journal Article] Gene therapy improves dental manifestations in hypophosphatasia model mice2017
- Author(s)
  Okawa R, Iijima O, Kishino M, Okawa H, Toyosawa S, Sugano-Tajima H, Shimada T, Okada T, Ozono K, Ooshima T, Nakano K.
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: 印刷中
- DOI
  10.1111/jre.12412
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11364
[Journal Article] Oral manifestations of Japanese patients with osteogenesis imperfecta2017
- Author(s)
  Okawa R, Kubota T, Kitaoka T, Kokomoto K, Ozono K, Nakano K.
- Journal Title
  
  Pediatric Dental Journal
  
  Volume: 印刷中
- DOI
  10.1016/j.pdj.2017.02.001
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11364
[Journal Article] Report of two dental patients diagnosed with hypophosphateasia2016
- Author(s)
  Rena Okawa, Taichi Kitaoka, Kanae Saga, Keiich Ozono and Kazuhiko Nakano
- Journal Title
  
  Journal of Clinical Case Reports
  
  Volume: 6 Pages: 704-704
- DOI
  10.4172/2165-7920.1000704
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11364
[Journal Article] 小児における血清NT-proCNP値測定の意義－年齢，成長速度及びGH治療反応性－2014
- Author(s)
  窪田拓生，三浦弘司，王薇，北岡太一，大幡泰久，山本景子，藤原誠，橘真紀子，三善陽子，難波範行，大薗恵一
- Journal Title
  
  ホルモンと臨床
  
  Volume: 60 Pages: 41-43
- Data Source
  KAKENHI-PROJECT-24390264
[Journal Article] Overgrowth syndrome associated with a gain-of-functionmutation of the natriuretic 　　peptide receptor 2 (NPR2) gene.2014
- Author(s)
  Miura K, Kim OH, Lee HR, Namba N, Michigami T, Yoo WJ, Choi H, Ozono K, Cho TJ.
- Journal Title
  
  Am J Med Genet A
  
  Volume: 164A Pages: 156-163
- DOI
  10.1002/ajmg.a.36218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390264
[Journal Article] Weaver syndrome and EZH2 mutations:Clarifying the clinical phenotype.2013
- Author(s)
  Ozono K
- Journal Title
  
  Am J Med Gene A
  
  Volume: 161A(12) Pages: 2972-2980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390264
[Journal Article] 遺伝性骨粗鬆症2013
- Author(s)
  大薗恵一
- Journal Title
  
  最新の骨粗鬆症学-骨粗鬆症の最新知見-
  
  Volume: 71 　増刊号2 Pages: 583-588
- Data Source
  KAKENHI-PROJECT-24390264
[Journal Article] Pediatric aspects of skeletal dysplasia.2012
- Author(s)
  Ozono K
- Journal Title
  
  Pediatr Endocrinol Rev
  
  Volume: 10 Suppl 1 Pages: 35-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390264
[Journal Article] 現代の栄養欠乏としてのビタミンD欠乏2012
- Author(s)
  大薗恵一
- Journal Title
  
  Vitamins(Japan)
  
  Volume: 86(1) Pages: 28-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] 現代の栄養欠乏としてのビタミンD欠乏2012
- Author(s)
  大薗恵一
- Journal Title
  
  Vitamins (Japan)
  
  Volume: 86(1) Pages: 28-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] 可溶型α-Klotho濃度測定の意義2012
- Author(s)
  大幡泰久, 大薗恵一
- Journal Title
  
  季刊腎と骨代謝
  
  Volume: 25(1) Pages: 41-46
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] Linear nevus sebaceous syndrome with hypophosphatemic rickets with elevated FGF-232012
- Author(s)
  Narazaki R, Ihara K, Namba N, Matsuzaki H, Ozono K, Hara T.
- Journal Title
  
  Pediatr Nephrol
  
  Volume: 27(5) Pages: 861-863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] Lysosomal storage causes cellular dysfunction in mucolipidosis II skin fibroblasts2011
- Author(s)
  Otomo T, Higaki K, Nanba E, Ozono K, Sakai N.
- Journal Title
  
  J Biol Chem
  
  Volume: 286(40) Pages: 35283-35290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] A Male Patient with Humoral Hypercalcemia of Malignancy(HHM) with Leukocytosis Caused by Cutaneous Squamous Cell Carcinoma Resulting from Recessive Dystrophic Epidermolysis Bullosa2011
- Author(s)
  Miura K, Umegaki N, Kitaoka T, Kubota T, Namba N, Etani Y, Hirai H, Kogaki S, Nakajima S, Takahashi Y, Tamai K, Katayama I, Ozono K.
- Journal Title
  
  Clin Pediatr Endocrinol
  
  Volume: 20(3) Pages: 65-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] 小児とビタミンD2011
- Author(s)
  大薗恵一
- Journal Title
  
  THE BONE
  
  Volume: 25(3) Pages: 105-110
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] 子どもの骨・関節疾患.診断と治療2011
- Author(s)
  大薗恵一
- Journal Title
  
  総合臨床
  
  Volume: 60(10) Pages: 2151-2152
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] Circulating levels of soluble alpha-Klotho are markedly elevated in human umbilical cord blood2011
- Author(s)
  Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y, Ozono K.
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: 96(6) Pages: 943-947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] Kitaoka T, Namba N, Miura K, Kubota T, Ohata Y, Fujiwara M, Hirai H, Yamamoto T, Ozono K.2011
- Author(s)
  Kitaoka T, Namba N, Miura K, Kubota T, Ohata Y, Fujiwara M, Hirai H, Yamamoto T, Ozono K.
- Journal Title
  
  J Bone Miner Metab
  
  Volume: 29(5) Pages: 598-605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] 主要な生体調節臓器としての骨2011
- Author(s)
  大薗恵一
- Journal Title
  
  生産と技術
  
  Volume: 63(3) Pages: 77-82
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] 小児とビタミン2011
- Author(s)
  大薗恵一
- Journal Title
  
  D. THE BONE
  
  Volume: 25(3) Pages: 105-110
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] カルシウム感知受容体における病態2011
- Author(s)
  難波範行, 大薗恵一
- Journal Title
  
  臨床検査
  
  Volume: 55(10) Pages: 973-978
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] Elevated Bone Turnover in an Infantile Patient with Mucolipidosis II ; No Association with Hyperparathyroidism2011
- Author(s)
  Otomo T, Yamamoto T, Fujikawa Y, Shimotsuji T, Ozono K.
- Journal Title
  
  Clin Pediatr Endocrinol
  
  Volume: 20(1) Pages: 7-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] Both FGF23 and extracellular phosphate activate Raf/ MEK/ ERK pathway via FGF receptors in HEK293 cells2010
- Author(s)
  Yamazaki M, Ozono K, Okada T, Tachikawa K, Kondou H, Ohata Y, Michigami T.
- Journal Title
  
  J Cell Biochem
  
  Volume: 111(5) Pages: 1210-1221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] Signaling of extracellular inorganic phosphate up-regulates cyclin D1 expression in proliferating chondrocytes via the Na+/ Pi cotransporter Pit-1 and Raf/ MEK/ ERK pathway2010
- Author(s)
  Kimata M, Michigami T, Tachikawa K, Okada T, Koshimizu T, Yamazaki M, Kogo M, Ozono K.
- Journal Title
  
  Bone
  
  Volume: 47(5) Pages: 938-947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] Severe arterial hypertension : a possible complication of McCune-Albright syndrome2009
- Author(s)
  Ohata Y, Yamamoto T, Ozono K(9番目),(他6名)
- Journal Title
  
  Eur J Pediate (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591204
[Journal Article] Wnt signaling in bone metabolism.2009
- Author(s)
  Kubota T, Michigami T, Ozono K.
- Journal Title
  
  J Bone Miner Metab
  
  Volume: 27(3) Pages: 265-271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] Oncogenic nucleoporin CAN/ Nup214 interacts with vitamin D receptor and modulates its function2009
- Author(s)
  Miyauchi Y, Sakaguchi N, Okada T, Makishima M, Ozono K, Michigami T.
- Journal Title
  
  J Cell Biochem
  
  Volume: 106(6) Pages: 1090-1101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319
[Journal Article] Causes and Differential Diagnosis of Hypocalcemia - Recommendation Proposed by Expert Panel Supported by Ministry of Health2009
- Author(s)
  Fukumoto S, Namba N, Ozono K,(他8名)
- Journal Title
  
  Labour and Welfare.Japan -Endocr J (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591204
[Journal Article] PTH/cAMP/PKA Signaling Facilitates Canonical Wnt Signaling Via Inactivation of Glycogen Synthase Kinase-3βin Osteoblastic saos-2 Cells.Journal of Cellular2008
- Author(s)
  Suzuki A, Ozono K, Kubota T, (他3名)
- Journal Title
  
  Biochemistry 104(1)
  
  Pages: 304-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591204
[Journal Article] Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients : proposal of diagnostic criteria using FGF23 measurement2008
- Author(s)
  Endo I, Fukumoto S, Ozono K,(他8名)
- Journal Title
  
  Bone 42(6)
  
  Pages: 1235-1239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591204
[Journal Article] 低リン血症性疾患の病態と治療-クル病/骨軟化症を含めて-2008
- Author(s)
  大薗恵一
- Journal Title
  
  THE BONE 22(6)
  
  Pages: 747-751
- Data Source
  KAKENHI-PROJECT-19591204
[Journal Article] Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings2008
- Author(s)
  Miyoshi Y, Akagi M, Ozono K(14番目),(他11名)
- Journal Title
  
  Clin Genet 73(6)
  
  Pages: 535-544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591204
[Journal Article] Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd2008
- Author(s)
  Kubota T, Michigami T, Ozono K(10番目),(他7名)
- Journal Title
  
  J Bone Miner Res 23(10)
  
  Pages: 1661-1671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591204
[Journal Article] 低リン血症性疾患の病態と治療-クル病/骨軟化症を含めて-2008
- Author(s)
  大薗恵一
- Journal Title
  
  THE BONE 22(6)
  
  Pages: 747-751
- Data Source
  KAKENHI-PROJECT-19591204
[Journal Article] The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity2008
- Author(s)
  Gordillo M, Vega H, Ozono K(23番目)(他23名)
- Journal Title
  
  Hum Mol Genet 17(14)
  
  Pages: 2172-2180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591204
[Journal Article] Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARg pathway.2007
- Author(s)
  Kawai M, Namba N, Mushiake S, Etani Y, Nishimura R, Makishima M, Ozono K
- Journal Title
  
  J Mol Endocrinol. 38(1)
  
  Pages: 19-34
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591087
[Journal Article] Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARγ pathway.2007
- Author(s)
  Kawai M, Namba N, Mushiake S, Etani Y, Nishimura R, Makishima M, Ozono K
- Journal Title
  
  J Mol Endocrinol. 38(1)
  
  Pages: 19-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591087
[Journal Article] Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPAR{gamma} pathway.2007
- Author(s)
  Kawai M, Namba N, Mushiake S, Etani Y, Nishimura R, Makishima M, Ozono K
- Journal Title
  
  J Mol Endocrinol. 38(1)
  
  Pages: 19-34
- Data Source
  KAKENHI-PROJECT-17591087
[Journal Article] Pathological variations in pediatric liver diseases characterized by fatty deposition to the hepatocytes.2007
- Author(s)
  Mushiake S, Etani Y, Miyoshi Y, Bessho K, Kawamoto K, Ozono K
- Journal Title
  
  Hepatology 42(4)suppl
  
  Pages: 473-473
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591087
[Journal Article] Novel mutation of gene coding for glial fibrillary acidic protein in a Japanese patient with Alexander disease2006
- Author(s)
  Kawai M, Sakai N, Miyake S, Tsukamoto H, Akagi M, Inui K, Mushiake S, Taniike M, Ozono K.
- Journal Title
  
  Brain Dev 28(6)
  
  Pages: 60-62
- Data Source
  KAKENHI-PROJECT-16591026
[Journal Article] Novel mutation of gene coding for glial fibrillary acidic protein in a Jananese patient with Alexander disease2006
- Author(s)
  Kawai M, Sakai N, Miyake S, Tsukamoto H, Akagi M, Inui K, Mushiake S, Taniike M, Ozono K.
- Journal Title
  
  Brain Dev 28(6)
  
  Pages: 60-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591026
[Journal Article] Novel mutation of gene coding for glial fibrillary acidic protein in a Japanese patient with Alexander disease2006
- Author(s)
  Kawai M, Sakai N, Miyake S, Tsukamoto H, Akagi M, Inui K, Mushiake S, Taniike M, Ozono K.
- Journal Title
  
  Brain Dev 28.6
  
  Pages: 60-62
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591026
[Journal Article] Characterization of the sensitivity of lymphoblastoid cell lines to various stress agents in Roberts syndrome2006
- Author(s)
  Gordillo M, Vega H, Sakai N, Tsukamoto H, Ozono K, Inui K
- Journal Title
  
  Med J Osaka Univ 49(1-4)
  
  Pages: 29-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591026
[Journal Article] Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion2005
- Author(s)
  Vega H, Waisfisz Q, Gordillo M, Sakai N, Yanagihara I, Yamada M, van Gosliga D, Kayserili H, Xu C, Ozono K, Jabs EW, Inui K, Joenje H.
- Journal Title
  
  Nat Genet 37.5
  
  Pages: 468-470
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591026
[Journal Article] Pathological variations in pediatric liver diseases characterized by fatty deposition to the hepatocytes.2005
- Author(s)
  Mushiake S, Etani Y, Miyoshi Y, Bessho K, Kawamoto K, Ozono K
- Journal Title
  
  Hepatology. 42(4)(suppl.)
  
  Pages: 473-473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591087
[Journal Article] Pathological variations in pediatric liver diseases characterized by fatty deposition to the hepatocytes.2005
- Author(s)
  Mushiake S, Etani Y, Miyoshi Y, Bessho K, Kawamoto K, Ozono K
- Journal Title
  
  Hepatology 42(4)(suppl.)
  
  Pages: 473-473
- Data Source
  KAKENHI-PROJECT-17591087
[Journal Article] Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion2005
- Author(s)
  Vega H, Waisfisz Q, Gordillo M, Sakai N, Yanagihara I, Yamada M, van Gosliga D, Kayserili H, Xu C, Ozono K, Jabs EW, Inui K, Joenie H.
- Journal Title
  
  Nat Genet 37(5)
  
  Pages: 468-470
- Data Source
  KAKENHI-PROJECT-16591026
[Journal Article] Successful stenting for renal artery stenosis in a patient with Alagille syndrome.2005
- Author(s)
  Hirai H, Santo Y, Kogaki S, Mushiake S, Nakatsuchi Y, Nakajima S, Ozono K.
- Journal Title
  
  Pediatric Nephrology 20(6)
  
  Pages: 831-833
- Data Source
  KAKENHI-PROJECT-17591087
[Journal Article] Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion2005
- Author(s)
  Vega H, Waisfisz Q, Gordillo M, Sakai N, Yanagihara I, Yamada M, van Gosliga D, Kayserili H, Xu C, Ozono K, Jabs EW, Inui K, Joenje H.
- Journal Title
  
  Nat Genet 37(5)
  
  Pages: 468-470
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591026
[Journal Article] Characterization of the sensitivity of lymphoblastoid cell lines to various stress agents in Roberts syndrome
- Author(s)
  Gordillo M, Vega H, Sakai N.Tsukamoto H, Ozono K, Inui K
- Journal Title
  
  Med J Osaka Univ in press
- Data Source
  KAKENHI-PROJECT-16591026
[Journal Article] Characterization of the sensitivity of lymphoblastoid cell lines to various stress agents in Roberts syndrome
- Author(s)
  Gordillo M, Vega H, Sakai N, Tsukamoto H, Ozono K, Inui K
- Journal Title
  
  Med J Osaka Univ in press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591026
[Journal Article] Six novel mutations detected in GALC gene in 17 Japanese patients with Krabbe disease and new genotype-phenotype correlation
- Author(s)
  Xu C, Sakai N, Taniike M, Inui K, Ozono K
- Journal Title
  
  J Hum Genet in press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591026
[Journal Article] Six novel mutations detected in GALC gene in 17 Japanese patients with Krabbe disease and new genotype-phenotype correlation
- Author(s)
  Xu C, Sakai N, Taniike M, Inui, Ozono K
- Journal Title
  
  J Hum Genet (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591026
[Journal Article] Six novel mutations detected in GALC gene in 17 Japanese patients with Krabbe disease and new genotype-phenotype correlation
- Author(s)
  Xu C, Sakai N, Taniike M, Inui, Ozono K
- Journal Title
  
  J Hum Genet in press
- Data Source
  KAKENHI-PROJECT-16591026
[Presentation] 小児科医と小児歯科医で共観している低ホスファターゼ症の5症例2017
- Author(s)
  大川玲奈，北岡太一，窪田拓生，大薗恵一，仲野和彦．
- Organizer
  第34回小児代謝性骨疾患研究会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府吹田市）
- Year and Date
  2017-01-21
- Data Source
  KAKENHI-PROJECT-15K11364
[Presentation] 生後1日目よりALP酵素補充を行った周産期重症型低ホスファターゼ症の4年間の経過2017
- Author(s)
  山村なつみ、道上敏美、一木容子、白石　淳、北島博之、立川加奈子、大川玲奈、仲野和彦、中野慎也、藤原香緒里、里村憲一、和田和子、大薗恵一、山本勝輔
- Organizer
  第12回ALPS研究会
- Data Source
  KAKENHI-PROJECT-15K11364
[Presentation] 小児内分泌-骨ミネラル異常症を中心として-2014
- Author(s)
  大薗恵一
- Organizer
  第23回　臨床内分泌代謝Update
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-24390264
[Presentation] 成長障害診療の現在と未来2013
- Author(s)
  大薗恵一
- Organizer
  第24回　日本小児科医会総会フォーラム
- Place of Presentation
  大阪市中央公会堂
- Data Source
  KAKENHI-PROJECT-24390264
[Presentation] 骨芽細胞・骨細胞の制御と疾患2013
- Author(s)
  大薗恵一
- Organizer
  第57回　日本リウマチ学会総会・学術集会第22回　国際リウマチシンポジウム
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24390264
[Presentation] 骨系統疾患の基礎と臨床-小児科医の立場から-2012
- Author(s)
  大薗恵一
- Organizer
  第28回小児成長研究会
- Place of Presentation
  霞山会館霞ヶ関コモンゲート(東京都)(招待講演)
- Year and Date
  2012-07-28
- Data Source
  KAKENHI-PROJECT-24390264
[Presentation] Height determination and chondrocyte development-JSPE/ESPE2012
- Author(s)
  Ozono K
- Organizer
  51st Annual Meeting of the European Society for Paediatric Endocrinology
- Place of Presentation
  The Congress Center Leipzig (Leipzig, Germany)(招待講演)
- Year and Date
  2012-09-22
- Data Source
  KAKENHI-PROJECT-24390264
[Presentation] 骨系統疾患2012
- Author(s)
  大薗恵一
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  京王プラザホテル(東京都)(招待講演)
- Year and Date
  2012-07-19
- Data Source
  KAKENHI-PROJECT-24390264
[Presentation] 骨系統疾患の新たな治療法2012
- Author(s)
  大薗恵一
- Organizer
  第10回日本胎児治療学会第5回胎児骨系統疾患フォーラム併催
- Place of Presentation
  仙台市情報・産業プラザ(宮城県)(招待講演)
- Year and Date
  2012-12-02
- Data Source
  KAKENHI-PROJECT-24390264
[Presentation] management of patients with achondroplasia/hypochondroplasia2011
- Author(s)
  Ozono K
- Organizer
  Sungkyunkwan University seminar
- Place of Presentation
  Samsung Medical Center (Korea)(Invited lecture)
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-21591319
[Presentation] Recent advances in research and clinical practice for rickets2011
- Author(s)
  Ozono K.
- Organizer
  the Research Center for Rare Disease(Invited lecture)
- Place of Presentation
  Seoul National University Children' s Hospital(Korea)
- Year and Date
  2011-11-23
- Data Source
  KAKENHI-PROJECT-21591319
[Presentation] Recent advances in research and clinical practice for rickets2011
- Author(s)
  Ozono K
- Organizer
  the Research Center for Rare Disease
- Place of Presentation
  Seoul National University Children's Hospital (Korea)(Invited lecture)
- Year and Date
  2011-11-23
- Data Source
  KAKENHI-PROJECT-21591319
[Presentation] 小児科医が知っておくべき骨系統疾患2011
- Author(s)
  大薗恵一
- Organizer
  第23回奈良小児内分泌研究会
- Place of Presentation
  奈良県立医科大学(奈良)(特別講演)
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-21591319
[Presentation] 小児科医が知っておくべき骨系統疾患2011
- Author(s)
  大薗恵一
- Organizer
  第23回奈良小児内分泌研究会(特別講演)
- Place of Presentation
  奈良県立医科大学(奈良)
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-21591319
[Presentation] Osteoporosis and osteopetrosis in the young2011
- Author(s)
  Ozono K
- Organizer
  IOF Regionals-2nd Asia-Pacific Osteoporosis and Bone Meeting being held in conjunction with the ANZBMS Annual Scientific Meeting and JSBMR
- Place of Presentation
  GOLD COAST CONVENTION CENTRE (Australia)
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-21591319
[Presentation] 周産期のカルシウムリン代謝2011
- Author(s)
  大薗恵一
- Organizer
  第19回Bone Research Joint Meeting
- Place of Presentation
  大阪大学(大阪)
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-21591319
[Presentation] management of patients with achondroplasia/ hypochondroplasia2011
- Author(s)
  Ozono K.
- Organizer
  Sungkyunkwan University seminar(Invited lecture)
- Place of Presentation
  Samsung Medical Center(Korea)
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-21591319
[Presentation] Osteoporosis and osteopetrosis in the young2011
- Author(s)
  Ozono K.
- Organizer
  IOF Regionals-2nd Asia-Pacific Osteoporosis and Bone Meeting being held in conjunction with the ANZBMS Annual Scientific Meeting and JSBMR
- Place of Presentation
  GOLD COAST CONVENTION CENTRE(Australia)
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-21591319
[Presentation] 現代の栄養欠乏としてのビタミンD欠乏2011
- Author(s)
  大薗恵一
- Organizer
  日本ビタミン学会第63回大会
- Place of Presentation
  安田女子大学(広島)
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-21591319
[Presentation] 骨量を規定する新たな遺伝子LRP6に変異を有するマウスの解析2008
- Author(s)
  大薗恵一
- Organizer
  第42回日本小児内分泌学会学術集
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-19591204
[Presentation] 血清カルシウム(Ca)・リン(P)値の異常とその原因2007
- Author(s)
  大薗恵一
- Organizer
  第173回大阪小児科学会
- Place of Presentation
  大阪市
- Year and Date
  2007-04-07
- Data Source
  KAKENHI-PROJECT-19591204
[Presentation] 低身長症例における血清NT-proCNP値測定の有用性-成長速度及びGH治療反応性-
- Author(s)
  窪田拓生，三浦弘司，王薇，北岡太一，大幡泰久，山本景子，藤原誠，橘真紀子，三善陽子，難波範行，大薗恵一
- Organizer
  第87回　日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24390264
[Presentation] 症例をもとに解説するカルシウム代謝異常症Update
- Author(s)
  大薗恵一
- Organizer
  第18回　鹿児島県小児内分泌研究会（特別講演）
- Place of Presentation
  ホテルパレスイン鹿児島4F鳳凰の間
- Data Source
  KAKENHI-PROJECT-24390264
[Presentation] 治療対象となってきた骨系統疾患
- Author(s)
  大薗恵一
- Organizer
  第13回　熊本内分泌代謝フォーラム（特別講演）
- Place of Presentation
  くまもと県民交流館パレア会議室2
- Invited
- Data Source
  KAKENHI-PROJECT-24390264
[Presentation] 軟骨無形成症の合併症とその治療、先進医療も含めて
- Author(s)
  大薗恵一
- Organizer
  第29回　つくしんぼ総会
- Place of Presentation
  大阪市長居障がい者スポーツセンター
- Data Source
  KAKENHI-PROJECT-24390264
[Presentation] Serum Levels of Amino-terminal Propepride of C-type Natriuretic Peptide may Predict Growth Response to Groeth Hormone Treatment in Patients with Achondroplasia /Hypochondroplasia.
- Author(s)
  Kubota k，Miura K，Wang W，Yamamoto K，Fujiwara M，Ohata Y，Tachabana M，Kitaoka T，Miyoshi Y，Namba N，Ozono K
- Organizer
  ASBMR2014
- Place of Presentation
  アメリカ合衆国，ヒューストン
- Year and Date
  2014-09-12 – 2014-09-15
- Data Source
  KAKENHI-PROJECT-24390264

1. MICHIGAMI Toshimi (00301804)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
2. MUSHIAKE Sotaro (90291947)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
3. NAKAJIMA Shigeo (30270771)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SHIMA Masaaki (10252660)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAJIRI Hitoshi (80183458)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MIURA Kohji (30625695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. FUJIWARA Makoto (50625697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. MATSUMOTO Sayuri (10281122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MIYOSHI Eiji (20322183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ETANI Yuri (80346220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SAKAI Norio (30314313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
12. OKINAGA Takeshi (30362734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TANIIKE Masako (30263289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
14. KONDOU Hiroki (10373515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OKAWA RENA (80437384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
16. NAKANO Kazuhiko (00379083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
17. KITAOKA Taichi (20599229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
18. NAKANO Michiyo (30359848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
19. 尾形悦郎 (70013761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 柳澤純 (50301114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 市川智彦 (20241953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 名和田新 (10038820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 首藤紘一 (50012612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 梅園和彦 (50183752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 加藤茂明 (60204468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 山本威久 (30231674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 妻木範行 (50303938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 仲周平 (10589774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
29. 柳原格

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 大園恵一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OZONO Keiichi 大薗 恵一

大薗 惠一 オオゾノ ケイイチ

大薗 恵一 オオゾノ ケイイチ

大ぞつ 恵一 オオゾツ ケイイチ

Research Projects

Research Products

Co-Researchers

Analysis of mechanism of bone fragility and effects of drugs in osteogenesis imperfecta using a graft model for enchondral bone formationPrincipal InvestigatorOngoing

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Ozono KeiichiPrincipal Investigator

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Role of FGF23 in metabolic bone diseasesPrincipal Investigator

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The effect of calcitropic hormone on bone forming action of・-cateninsignalPrincipal Investigator

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Analysis of height-determining gene.Principal Investigator

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Functional analysis of megalin, a key molecule of reabsorption in renal tubular cells ; making and using RAP-transgenic micePrincipal Investigator

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Characterization of the expression of 1 alpha-hydroxylase in kidney and application to renal failurePrincipal Investigator

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OZONO Keiichi 大薗恵一

大薗惠一オオゾノケイイチ

大薗恵一オオゾノケイイチ

大ぞつ恵一オオゾツケイイチ

[Book] 骨研究最前線　アンチ・エイジングシリーズ　No.3 代謝・疾患のメカニズムから再生医療・創薬・リハビリ機器・機能性食品開発まで2013

[Book] ビタミンDと疾患　改訂版　-基礎の理解と臨床への応用-2013

[Book] 骨粗鬆症診療ハンドブック改訂5版2012