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OKUBO Satoko  大久 保聡子

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OHKUBO Satoko  大久保 聡子

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Researcher Number 20274954
External Links
Affiliation (based on the past Project Information) *help 2010: 国立医薬品食品衛生研究所, 研究員
2008: 国立医薬品食品衛生研究所, 研究員
2007 – 2008: 医薬品食品衛生研, 研究員
2005 – 2007: 国立医薬品食品衛生研究所, 薬理部, 研究員
2001 – 2003: 東北大学, 大学院・薬学研究科, 助手
1999: Fukushima Med.Univ.Pharmacol. Research Assistant, 医学部, 助手
Review Section/Research Field
Principal Investigator
Neurochemistry/Neuropharmacology / Biological pharmacy
Except Principal Investigator
Biological pharmacy / Biological Sciences / General pharmacology / Neurochemistry/Neuropharmacology
Keywords
Principal Investigator
adenosine / methyo-β-cyclodextrin / ecto-nucleotidase / NG108-15 / アデノシン / β-シクロデキストリン / フロティリン / P2Y_2受容体 / ATP / 細胞内Ca^<2+>濃度 / マイクロドメイン / 脂質ラフト … More
Except Principal Investigator
… More ATP / P2受容体 / ミクログリア / アストロサイト / 4.1G / G_<12> / ecto-nucleotidase / RT-PCR / mRNA / 炎症 / UTP / Adngiotension / Pressure-natriuresis] / Hypertension / 庄-利尿 / アンジオテンシン / 圧-利尿 / 高血圧 / two hybrid system / Tctes-1 / proteasme / PTH receptor / thromboxane A_2 receptor / G protein-coupled receptor / α7 / PA28γ / TP-β / TP-α / two hybrid システム / two hybridシステム / Tctex-1 / プロテアソーム / 副甲状腺ホルモン受容体 / トロンボキサンA_2受容体 / Gタンパク質共役型受容体 / adenosine / P1 purinoceptor / central nervous system / P2 purinoceptor / P_2プリン受容体 / 膀胱平滑筋 / 妊娠子宮 / 末梢組織 / アデノシン / P1プリン受容体 / 中枢神経 / P2プリン受容体 / 神経細胞障害 / サイトカイン / 脳傷害 / TNF-α / TGF-β / 傷害 / 貪食センサー / モーダルシフト / ATPセンサー / UDP / 神経細胞傷害 / 貪食 / カルシウム / P2Y受容体 / グリア-神経細胞連関 / アセチルコリンM1受容体 / グリアー神経細胞連関 / 開口放出 / 海馬 / 可塑性 / P2 受容体 / グリア細胞 / フィブロネクチン / P2X4 / 脊髄 / 神経因性疼痛 Less
  • Research Projects

    (8 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (9 People)
  •  脳ミクログリアの細胞外環境感知機構における脂質ラフトの役割に関する研究Principal Investigator

    • Principal Investigator
      大久保 聡子
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      National Institute of Health Sciences
  •  Information processing by the interaction of the ATP-sensors and mechano-sensors

    • Principal Investigator
      KOIZUMI Schuichi
    • Project Period (FY)
      2006 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Yamanashi
  •  脊髄グリア回路網による痛覚伝達回路制御に関する研究

    • Principal Investigator
      KOIZUMI Schuichi
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Health Sciences
  •  Mechanisms of synaptic plasticity mediated by glia

    • Principal Investigator
      KOIZUMI Schuichi
    • Project Period (FY)
      2005 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      University of Yamanashi
      National Institute of Health Sciences
  •  Research for the molecular mechanism regulating multu-functresponses mediated via G protein-coupled receptors

    • Principal Investigator
      NAKAHATA Norimichi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      TOHOKU UNIVERSITY
  •  Role and mechanisms of pressure-natriuresis relation ship in hypertensive rats

    • Principal Investigator
      YOSHIDA Makoto
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tohoku University
  •  細胞外ATPのマイクロドメインにおける代謝と受容体活性化機構に関する研究Principal Investigator

    • Principal Investigator
      大久保 聡子
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tohoku University
  •  Tissue distribution and physiorogical function of ATP receptors

    • Principal Investigator
      MATSUOKA Isao
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Fukushima Medical University, School of Medicine

All 2007 2006

All Journal Article Presentation

  • [Journal Article] ATP stimulates interleukin-6 production via P2Y receptors in human H_aC_aT keratinocytes.2006

    • Author(s)
      Yoshida H, Kobayashi D, Ohkubo S, Nakahata N
    • Journal Title

      Eur J Pharmacol. 540

      Pages: 1-9

    • Data Source
      KAKENHI-PLANNED-18077011
  • [Journal Article] Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C.2006

    • Author(s)
      Saito M, Hori M, Obara Y, Ohizumi Y, Ohkubo S, Nakahara N.
    • Journal Title

      Eur J Pharm Sci. 28(4)

      Pages: 263-271

    • Data Source
      KAKENHI-PROJECT-17300124
  • [Journal Article] Contribution of extracellular signal-regulated kinase to UTP-induced interleukin-6 biosynthesis in H_aC_aT keratinocytes.2006

    • Author(s)
      Kobayashi D, Ohkubo S, Nakahata N
    • Journal Title

      J Pharmacol Sci. 102 (4)

      Pages: 368-376

    • Data Source
      KAKENHI-PLANNED-18077011
  • [Presentation] Enhancement of P2Y6 receptor-mediated signaling by lipopolysaccharide in rat hippocampal astrocytes.2007

    • Author(s)
      Ohkubo, S., Koizumi, S.
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-17300124
  • [Presentation] Adenosine enhances fluoxetine-induced BDNF production in rat hippocampal astrocytes2007

    • Author(s)
      Suto, K., Ohkubo, S., Honda, K. and Koizumi, S.
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-17300124
  • [Presentation] Lipopolysaccharide alters P2Y receptor-mediated signaling in rat astrocytes via RGS-mediated mechanisms2006

    • Author(s)
      Ohkubo, S. and Koizumi, S
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      Atlanta, USA
    • Data Source
      KAKENHI-PROJECT-17300124
  • [Presentation] Intimate interaction mediated by P2Y_2 receptors between astrocytes and pericytes2006

    • Author(s)
      Koizumi, S., Fujishita, K. Sueishi, K., Kataoka, Y., Ohkubo, S. and Inoue, K.
    • Organizer
      8^<th> ISAAN
    • Place of Presentation
      Ferrara, Italy
    • Data Source
      KAKENHI-PROJECT-17300124
  • [Presentation] ラットアストロサイトにおけるリポポリサッカライドによるP2 受容体シグナルの変化2006

    • Author(s)
      大久保聡子、多田薫、斉藤秀俊、小泉修一
    • Organizer
      第79回日本薬理学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-17300124
  • 1.  KOIZUMI Schuichi (10280752)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 2.  FUJISHITA Kayoko (10443102)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  NAKAHATA Norimichi (60045804)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  YOSHIDA Makoto (90201011)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  KATAOKA Yasufumi (70136513)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  SHIBATA Keisuke (50580411)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  MATSUOKA Isao (10145633)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  HONMA Shigeyoshi (20344682)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  SUKEGAWA Jun (30187687)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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