YAMADA Takashi 山田剛司

… Alternative Names

山田剛司ヤマダタケシ

YAMADA Takeshi 山田剛司

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Researcher Number	20278592
Other IDs
Affiliation (Current)	2025: 大阪医科薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2016: 大阪薬科大学, 薬学部, 准教授(移行) 2011 – 2015: 大阪薬科大学, 薬学部, 准教授 2009 – 2010: 大阪薬科大学, 薬学部, 講師 1998 – 2001: 大阪薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Natural medicines / Chemical pharmacy Except Principal Investigator Chemical pharmacy / Physical pharmacy
Keywords	Principal Investigator 海洋菌類 / 海洋天然物 / 抗腫瘍性物質 / 細胞毒性物質 / 真菌 / 海洋生物 / altercrasin A / pseurotins / tandyukisins / 天然有機化合物 … More / 新規細胞毒性物質 / Chaetomium globosum / Aspergillus fumigatus / Alternaria属真菌 / Trichoderma harzianum / 細胞毒性物質産生菌 … More Except Principal Investigator marine microorganism / marine organism / cytotoxicity / 菌代謝産物 / 細胞増殖阻害 / 海洋微生物 / 海洋生物 / 細胞毒性 / 抗腫瘍性物質 / cell adhesion inhibition / tubulin inhibition / topoisomerase inhibition / protein kinase inhibition / antitumor compound / トポイソメラーゼ阻害 / チューブリン阻害 / 細胞接着阻害 / プロテインキナーゼ阻害 / 抗腫瘍性 / metabolite / antineoplastic compound / レセプター / リガンド / 糖尿病血管合併症 / 合理的創薬 / 超遠心分析 / 超遠心分析用蛍光測定装置 / 分子間相互作用 / 糖尿病合併症 / 終末糖化産物 / 水和 / 等温滴定型熱量計 / PPARγ / AGE-RAGE相互作用 / AGE受容体 / 合理的薬物設計 / NMR / バーチャルスクリーニング / SBDD / RAGE / AGE / 最終糖化産物 / 糖尿病 / 創薬 Less

Search of the seeds of an antineoplastic drug and development of a lead compound which marine organism origin fungi producePrincipal Investigator
- Principal Investigator
  
  Yamada Takeshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Osaka University of Pharmaceutical Sciences
Search of the seeds of an antineoplastic drug and development of a lead compound which marine organism origin fungi producePrincipal Investigator
- Principal Investigator
  
  YAMADA Takeshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Research and development of drugs of prevention and treatment for complication of diabetes targeting the receptor of advanced glycation end products(RAGE)
- Principal Investigator
  
  KOBAYASHI Yuji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Search and development of antitumor sed compounds produced yb microorganisms from marine organisms
- Principal Investigator
  
  NUMATA Atsushi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University of pharmaceutical Sciences, Assistant
Development of antitumor lead compounds produced by microorganisms from marine organisms
- Principal Investigator
  
  NUMATA Atsushi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences

All 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Assignment of the CD Cotton Effect to the Chiral Center in Pseurotins, and the Stereochemical Revision of Pseurotin A22016
- Author(s)
  Takeshi Yamada, Mina Ohshima, Kaori Yuasa, Takashi Kikuchi, Reiko Tanaka
- Journal Title
  
  Marine Drugs
  
  Volume: 14 Issue: 4 Pages: 74-80
- DOI
  10.3390/md14040074
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460136
[Journal Article] Tandyukisins E and F, novel cytotoxic decalin derivatives isolated from a marine sponge-derived fungus2016
- Author(s)
  Mayo Suzue, Takashi Kikuchi, Reiko Tanaka, Takeshi Yamada
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 57 Issue: 46 Pages: 5070-5073
- DOI
  10.1016/j.tetlet.2016.10.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460136
[Journal Article] Determination of the chemical Structures of tandyukisins B–D, isolated from a marine sponge-derived fungus2015
- Author(s)
  Takeshi Yamada, Yoshihide Umebayashi, Maiko Kawashima, Yuma Sugiura, Takashi Kikuchi, Reiko Tanaka
- Journal Title
  
  Marine Drugs
  
  Volume: 13 Issue: 5 Pages: 3231-3240
- DOI
  10.3390/md13053231
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460136
[Journal Article] Altercrasin A, a novel decalin derivative with spirotetramic acid, produced by a sea urchin-derived Alternaria sp.2015
- Author(s)
  Takeshi Yamada, Takashi Kikuchi, Reiko Tanaka
- Journal Title
  
  Tetrahedron Letter
  
  Volume: 56 Issue: 10 Pages: 1229-1232
- DOI
  10.1016/j.tetlet.2015.01.066
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460136
[Journal Article] Tandyukisin, a novel ketoaldehyde decalin derivative, produced by a marine sponge-derived Trichoderma harzianum2014
- Author(s)
  Takeshi Yamada, Yuki Mizutani, Yoshihide Umebayashi, Naoko Inno, Maiko Kawashima, Takashi Kikuchi, Reiko Tanaka
- Journal Title
  
  Tetrahedton Lett
  
  Volume: 55 Issue: 3 Pages: 662-664
- DOI
  10.1016/j.tetlet.2013.11.107
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590028, KAKENHI-PROJECT-26460136
[Journal Article] Anthcolorins A–F, novel cytotoxic metabolites from a sea urchin-derived Aspergillus versicolor2013
- Author(s)
  Kyouko Nakanishi, Mitsunobu Doi, Yoshihide Usami, Taro Amagata, Katsuhiko Minoura, Reiko Tanaka, Atsushi Numata, Takeshi Yamada
- Journal Title
  
  Tetrahedron
  
  Volume: 69 Issue: 23 Pages: 4617-4623
- DOI
  10.1016/j.tet.2013.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590028
[Journal Article] Three new azaphilones produced by a marine fish-derived Chaetomium globosum2012
- Author(s)
  Takeshi Yamada, Masaaki Jinno, Takashi Kikuchi, Tetsuya Kajimoto, Atsushi Numata, Reiko Tanaka
- Journal Title
  
  Journal of Antibiotics
  
  Volume: 65 Issue: 8 Pages: 413-417
- DOI
  10.1038/ja.2012.40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590028
[Journal Article] Novel pyridino-α-pyrone sesquiterpene type pileotin produced by a sea urchin-derived Aspergillus sp.2012
- Author(s)
  Mayumi Kitano
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 53 Issue: 32 Pages: 4192-4194
- DOI
  10.1016/j.tetlet.2012.05.144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590028
[Journal Article] Three new azaphilones produced by a marine fish-derived Chaetomium globosum2012
- Author(s)
  Takeshi Yamada
- Journal Title
  
  Journal of Antibiotics
  
  Volume: 65 Issue: 49 Pages: 6685-6688
- DOI
  10.1016/j.tetlet.2012.09.108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590028
[Journal Article] Halichoblelides B and C, potent cytotoxic macrolides from a Streptomyces species separated from a marine fish2012
- Author(s)
  Takeshi Yamada, Takashi Kikuchi, Reiko Tanaka, Atsushi Numata
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 53 Issue: 23 Pages: 2842-2846
- DOI
  10.1016/j.tetlet.2012.03.114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590028
[Journal Article] New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities.2011
- Author(s)
  山田　剛司
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 19 Issue: 13 Pages: 4106-4113
- DOI
  10.1016/j.bmc.2011.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590028
[Journal Article] New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities2011
- Author(s)
  Takeshi Yamada, Yasuhide Muroga, Masaaki Jinno, Tetsuya Kajimoto, Yoshihide Usami, Atsushi Numata, Reiko Tanaka
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 19 Pages: 4106-4113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590028
[Journal Article] Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base2010
- Author(s)
  T. Nakamura, S. Meshitsuka, S. Kitagawa, N. Abe, J. Yamada, T. Ishino, H. Nakano, T. Tsuzuki, T. Doi, S. Fujii, Y. Kobayashi, M. Sekiguchi, Y. Yamagata J
- Journal Title
  
  Biol. Chem
  
  Volume: 285 Pages: 444-452
- URL
  http://www.jbc.org/content/285/1/444.long
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390013
[Presentation] ムラサキウニ由来真菌の産生する新規decalin 誘導体2016
- Author(s)
  田中亜純、久住祐介、山田剛司、菊地崇、田中麗子
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-26460136
[Presentation] クロイソカイメン由来真菌の産生する新規ジテルペンの化学構造2016
- Author(s)
  鈴江真世、新井貴順、山田剛司、菊地崇、田中麗子
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-26460136
[Presentation] ワカメ表皮から分離した真菌の産生する新規細胞毒性物質2016
- Author(s)
  広瀬恵美、松田美和、山田剛司、菊地崇、田中麗子
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-26460136
[Presentation] 海水魚由来真菌の産生するspiro-heterocyclic g-lactam -Pseurotin A の立体異性体の絶対構造-2016
- Author(s)
  湯浅香織、篠原莉奈、山田剛司、菊地崇、田中麗子
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-26460136
[Presentation] カイメン由来真菌の産生する新規細胞毒性物質の絶対構造2016
- Author(s)
  山田　剛司，鈴江　真世，杉浦　右真，菊地　崇，田中　麗子
- Organizer
  日本薬学会　第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460136
[Presentation] ムラサキウニ由来真菌の新規代謝産物altercrasin類の構造2016
- Author(s)
  田中　亜純，西井　拓巳，菊地　崇，田中　麗子，山田　剛司
- Organizer
  日本薬学会　第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460136
[Presentation] イソギンチャク由来真菌の産生するポリフェノール2016
- Author(s)
  徳水彩乃、工藤真希、山田剛司、菊地崇、田中麗子
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-26460136
[Presentation] クロイソカイメン由来真菌の産生する新規代謝物の絶対構造2014
- Author(s)
  山田剛司
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-29
- Data Source
  KAKENHI-PROJECT-23590028
[Presentation] クロイソカイメン由来真菌の産生する新規代謝物の絶対構造2014
- Author(s)
  山田　剛司，梅林　良英，河島　舞子，菊地　崇，田中　麗子
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-23590028
[Presentation] 海水魚由来真菌の代謝産物の絶対構造2012
- Author(s)
  山田　剛司
- Organizer
  日本薬学会　第132年会
- Place of Presentation
  北海道（札幌）
- Data Source
  KAKENHI-PROJECT-23590028
[Presentation] 海水魚由来真菌の代謝産物の絶対構造2012
- Author(s)
  山田剛司
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23590028
[Presentation] カイメン由来真菌の産生する新規代謝物の絶対構造（２）
- Author(s)
  山田　剛司，河島　舞子，杉浦　右真，菊地　崇，田中　麗子
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460136
[Presentation] 海水魚由来真菌の代謝産物の絶対構造
- Author(s)
  山田剛司
- Organizer
  第19回天然薬物の開発と応用シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23590028

1. NUMATA Atsushi (50067279)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. USAMI Yoshihide (70278589)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KOBAYASHI Yuji (20127228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. NISHIMURA Mitsuhiro (40510285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. IWAMOTO Chika

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMADA Takashi 山田 剛司

山田 剛司 ヤマダ タケシ

YAMADA Takeshi 山田 剛司

Research Projects

Research Products

Co-Researchers

Search of the seeds of an antineoplastic drug and development of a lead compound which marine organism origin fungi producePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search of the seeds of an antineoplastic drug and development of a lead compound which marine organism origin fungi producePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research and development of drugs of prevention and treatment for complication of diabetes targeting the receptor of advanced glycation end products(RAGE)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search and development of antitumor sed compounds produced yb microorganisms from marine organisms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of antitumor lead compounds produced by microorganisms from marine organisms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Assignment of the CD Cotton Effect to the Chiral Center in Pseurotins, and the Stereochemical Revision of Pseurotin A22016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tandyukisins E and F, novel cytotoxic decalin derivatives isolated from a marine sponge-derived fungus2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Determination of the chemical Structures of tandyukisins B&#8211;D, isolated from a marine sponge-derived fungus2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Altercrasin A, a novel decalin derivative with spirotetramic acid, produced by a sea urchin-derived Alternaria sp.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tandyukisin, a novel ketoaldehyde decalin derivative, produced by a marine sponge-derived Trichoderma harzianum2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anthcolorins A–F, novel cytotoxic metabolites from a sea urchin-derived Aspergillus versicolor2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three new azaphilones produced by a marine fish-derived Chaetomium globosum2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel pyridino-α-pyrone sesquiterpene type pileotin produced by a sea urchin-derived Aspergillus sp.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three new azaphilones produced by a marine fish-derived Chaetomium globosum2012

Author(s)

Journal Title

DOI

YAMADA Takashi 山田剛司

山田剛司ヤマダタケシ

YAMADA Takeshi 山田剛司

[Journal Article] Determination of the chemical Structures of tandyukisins B–D, isolated from a marine sponge-derived fungus2015