SHIGA Hidetoshi 志賀英敏

… Alternative Names

志賀英敏シガヒデトシ

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Researcher Number	20282478
Other IDs
External Links
Affiliation (Current)	2025: 帝京大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2002 – 2005: 千葉大学, 医学部附属病院, 講師 2000 – 2001: Chiba University, University Hospital, Lecturer, 医学部・附属病院, 講師 1999: 千葉大学, 医学部・附属病院, 助手 1998: 千葉大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Emergency medicine Except Principal Investigator General surgery / Emergency medicine
Keywords	Principal Investigator RT-PCR / IL-10 / IL-6 / IL-1 / SIRS / TNF-alpha / cytokine / gene expression / IL-1β / TNFα / サイトカイン / 遺伝子発現 … More Except Principal Investigator … More 多臓器不全 / サイトカイン / hypercytokinemia / cytokine / SIRS / 遺伝子多型 / Critical Care / 高サイトカイン血症 / 全身性炎症反応症候群 / T-SAAF / MPC-FX / multiple organ failure / SOFA / CIS / アポトーシス / tailor-made therapy / cytokine adsorbing column / genetic high resk / septic multiple organ failure / genetic polymorphism / 血液浄化法 / 個別化診療 / サイトカイン吸着 / 個別化治療 / サイトカイン吸着カラム / 遺伝的ハイリスク症例 / 敗血症性多臓器不全 / Tailor-made medicine / Hypercytokinemia / Multiple organ failure / Polymorphism (Genetics) / Cytokines / Tailor-made医療 / selective adsorption / 免疫吸着 / 選択的吸着剤 / 敗血症性ショック / 選択的吸着カラム / apoptosis modulation / cytokine modulation / apoptosis / アポトーシスモデュレーション / サイトカインモデュレーション / CHDF / Mortality Prediction / Apoptosis / Anoxic Necrosis / Cellular Injury / Severity Scoring System / Multiple Organ Failure / アノキシックネクローシス / ODAS / 予後予測 / アノキシック・ネクローシス / 細胞障害 / 重症度評価法 / 初期免疫 / 炎症反応 / 自然免疫 / 侵襲 / 敗血症 / 生体反応 / 遺伝学 / 医学 Less

Tailor-made therapy for patients with septic multiple organ failure using a cytokine adsorbing column based on genetic analysis of cytokine related gene polymorphisms
- Principal Investigator
  
  ODA Shigeto
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Chiba University
Predicting Onset of Secondary Multiple Organ Failure by Profiling of Cytokine Gene ExpressionPrincipal Investigator
- Principal Investigator
  
  SHIGA Hidetoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Chiba University
DNAマイクロアレイを用いた侵襲による生体反応に関する遺伝子分析と個別化治療
- Principal Investigator
  
  HIRASAWA Hiroyuki
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Chiba University
TAILOR-MADE MEDICINE AGAINST PATHOPHYSIOLOGICAL RESPONSE TO STRESS BASED ON THE GENOME ANALYSIS
- Principal Investigator
  
  HIRASAWA Hiroyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  CHIBA UNIVERSITY
DEVELOPMENT OF CYTOKINE ADSORPTION COLUMN AND THE TREATMENT OF MULTIPLE ORGAN FAILURE BY CYTOKINE ADSORPTION COLUMN
- Principal Investigator
  
  ODA Shigeto
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  CHIBA UNIVERSITY
Cytokine modulation with continuous hemodiafiltration for treatment and prevention of multiple organ failure
- Principal Investigator
  
  HIRASAWA Hiroyuki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Chiba University
Establishment of a new Severity Scoring System for the Patients with Multiple Organ Failure from the Aspect of Cellular Injury - Anoxic Necrosis and Apoptosis
- Principal Investigator
  
  ODA Shigeto
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Chiba University

All 2006 2005 2004 2003

All Journal Article

[Journal Article] Blood purification for hypercytokinemia.2006
- Author(s)
  Nakada T, Hirasawa H, Oda S, Shiga H, Matsuda K
- Journal Title
  
  Transfus Apher Sci 35
  
  Pages: 253-264
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] Blood purification for hypercytokinemia.2006
- Author(s)
  Taka-aki Nakada, Hiroyuki Hirasawa, Shigeto Oda, Hidetoshi Shiga, Ken-ichi Matsuda
- Journal Title
  
  Transfus Apher Sci 35
  
  Pages: 253-264
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] Cytokine-related genotypic differences in peak interleukin-6 blood levels of patients with SIRS and septic complications.2005
- Author(s)
  Watanabe E, Hirasawa H, Oda S, Shiga H, Matsuda K, et al.
- Journal Title
  
  J Trauma 59
  
  Pages: 1181-1190
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] Influence of toll-like receptor 4, CD14, tumor necrosis factor, and interleukine-10 gene polymorphisms on clinical outcome in Japanese critically ill patients.2005
- Author(s)
  Taka-aki Nakada, Hiroyuki Hirasawa, Shigeto Oda, Hidetoshi Shiga, Ken-ichi Matsuda, Masataka Nakamura, Eizo Watanabe, Ryuzo Abe, Masahiko Hatano, Takeshi Tokuhisa
- Journal Title
  
  J Surg Res 129
  
  Pages: 322-328
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] Indication and perspective of acute blood purifications for the treatment of septic shock2005
- Author(s)
  Watanabe E, Hirasawa H, Oda S, Shiga H, Matsuda K, Nakamura M, Abe R, Nakada T.
- Journal Title
  
  ICU & CCU 29(suppl)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591806
[Journal Article] Cytokine-related genotypic differences in peak interleukin-6 blood levels of patients with SIRS and septic complications.2005
- Author(s)
  Watanabe E, Hirasawa H, Oda S, Shiga H, Matsuda K, Nakamura M, Abe R, Nakada T.
- Journal Title
  
  Journal of Trauma 59・5
  
  Pages: 1181-1189
- Data Source
  KAKENHI-PROJECT-15659426
[Journal Article] Sequential measurement of IL-6 blood levels in patients with systemic inflammatory response syndrome (SIRS) /sepsis.2005
- Author(s)
  Shigeto Oda, Hiroyuki Hirasawa, Hidetoshi Shiga, et al.
- Journal Title
  
  Cytokine 29
  
  Pages: 169-175
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] Sequential measurement of IL-6 blood levels in patients with systemic inflammatory response syndrome (SIRS)/sepsis.2005
- Author(s)
  Shigeto Oda, Hiroyuki Hirasawa, Hidetoshi Shiga, Kazuya Nakanishi, Ken-ichi Matsuda, Masataka Nakamura
- Journal Title
  
  Cytokine 29
  
  Pages: 169-175
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] Cytokine-related genotypic differences in peak interleukin-6 blood levels of patients with SIRS and septic complications.2005
- Author(s)
  Eizo Watanabe, Hiroyuki Hirasawa, Shigeto Oda, Hidetoshi Shiga, Kenichi Matsuda, Masataka Nakamura, Eizo Watanabe, Ryuzo Abe, Takaaki Nakada
- Journal Title
  
  J Trauma 59
  
  Pages: 1181-1190
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] 緩徐持続血液浄化療法の適応と実際2005
- Author(s)
  幸部吉郎, 平澤博之, 織田成人, 志賀英敏, 松田兼一, ほか
- Journal Title
  
  内科 96
  
  Pages: 22-28
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] Influence of toll-like receptor 4, CD14, tumor necrosis factor, and interleukine-10 gene polymorphisms on clinical outcome in Japanese critically ill patients.2005
- Author(s)
  Nakada TA, Hirasawa M, Oda S, Shiga H, Matsuda K, Nakamura M, Watanabe E, Abe R, Hatano M, Tokuhisa T.
- Journal Title
  
  Journal of Surgical Research 129・2
  
  Pages: 322-328
- Data Source
  KAKENHI-PROJECT-15659426
[Journal Article] Sequential measurement of IL-6 blood levels in patients with systemic inflammatory response syndrome (SIRS)/sepsis2005
- Author(s)
  Oda S, Hirasawa H, Shiga H, Nakanish K, Matsuda K, Nakamura M
- Journal Title
  
  Cytokine 29・4
  
  Pages: 169-175
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] Influence of toll-like receptor 4,CD14, tumor necrosis factor, and interleukin-10 gene polymorphism on clinical outcome in Japanese critically ill patients.2005
- Author(s)
  Nakada K, Hirasawa H, Oda S, Shiga H, Matsuda K, et al.
- Journal Title
  
  J Surg Res 129
  
  Pages: 322-328
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] Management of intra-abdominal hypertension in patients with severe acute pancreatitis with continuous hemodiafiltration using a polymethyl methacrylate membrane hemofilter (PMMA-CHDF)2005
- Author(s)
  Oda S, Hirasawa H, Shiga H, Matsuda K, Nakamura M, et al.
- Journal Title
  
  Ther Apher Dial 9
  
  Pages: 355-361
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] SIRS・Shock患者におけるCytokine遺伝子多型別にみたCytokine血中濃度および臨床経過の検討2004
- Author(s)
  渡邉栄三, 平澤博之, 織田成人, 志賀英敏, 松田兼一, 仲村将高, 安部隆三, 中田孝明
- Journal Title
  
  日本Shock学会雑誌 19
  
  Pages: 43-49
- NAID
  10025680447
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370348
[Journal Article] Cytokine adsorptive property of various adsorbents in immunoadsorption columns and a newly developed adsorbent : An in vitro study2004
- Author(s)
  Oda S, Hirasawa H, Shiga H, Nakanish K, Matsuda K, Nakamura M, et al.
- Journal Title
  
  Blood Purification 22・6
  
  Pages: 530-536
- NAID
  120005908158
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] Cytokine adsorptive property of various adsorbents in immunoadsorption columns and a newly developed adsorbent : An in vitro study.2004
- Author(s)
  Oda S, Hirasawa H, Shiga H, et al.
- Journal Title
  
  Blood Purif 22
  
  Pages: 530-553
- NAID
  120005908158
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] SIRS・Shock患者におけるCytokine遺伝子多型別にみたCytokine血中濃度および臨床経過の検討2004
- Author(s)
  渡邊栄三, 平澤博之, 織田成人, 志賀英敏, 松田兼一, 仲村将高, 安部隆三, 中田孝明
- Journal Title
  
  日本Shock学会雑誌 19
  
  Pages: 43-49
- NAID
  10025680447
- Data Source
  KAKENHI-PROJECT-14370348
[Journal Article] Cytokine adsorptive property of various adsorbents in immunoadsorption columns and a newly developed adsorbent : An in vitro study.2004
- Author(s)
  Shigeto Oda, Hiroyuki Hirasawa, Hidetoshi Shiga, Kazuya Nakanishi, Ken-ichi Matsuda, Masataka Nakamura, Hiroyuki Ikeda, Masamune Sakai
- Journal Title
  
  Blood Purif 22
  
  Pages: 530-536
- NAID
  120005908158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] Cytokine-related genotypic differences in the cytokine blood levels and the clinical courses of the patients with SIRS and shock2004
- Author(s)
  Eizo Watanabe, Hiroyuki Hirasawa, Shigeto Oda, Hidetoshi Shiga, Kenichi Matsuda, Masataka Nakamura, Ryuzo Abe, Takaaki Nakada
- Journal Title
  
  Shock 19
  
  Pages: 43-49
- NAID
  10025680447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370348
[Journal Article] SIRS・Shock患者におけるCytokine遺伝子多型別にみたCytokine血中濃度および臨床経過の検討2004
- Author(s)
  渡邉栄三, 平澤博之, 織田成人, 志賀英敏, 松田兼一, 仲村将高, ほか
- Journal Title
  
  Shock 19・2
  
  Pages: 43-49
- NAID
  10025680447
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] 敗血症性ショックに対するPMMA-CHDF2004
- Author(s)
  織田成人, 平澤博之, 志賀英敏, 松田兼一, 仲村将高, 渡邉栄三
- Journal Title
  
  救急医学 28・11
  
  Pages: 1195-1199
- Data Source
  KAKENHI-PROJECT-16390514
[Journal Article] 重症感染症の病態とメディエーター2003
- Author(s)
  織田成人, 平澤博之, 志賀英敏, 松田兼一, 上野博一, 仲村将高, 渡邉栄三
- Journal Title
  
  日本外科学会雑誌 104
  
  Pages: 511-517
- NAID
  110003890303
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370348

1. HIRASAWA Hiroyuki (80114320)

# of Collaborated Projects: 7 results

# of Collaborated Products: 23 results
2. ODA Shigeto (90204205)

# of Collaborated Projects: 7 results

# of Collaborated Products: 23 results
3. MATSUDA Ken-ichi (60282480)

# of Collaborated Projects: 6 results

# of Collaborated Products: 21 results
4. NAKANISHI Kazuya (80272326)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. NAKAMURA Masataka (30315436)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
6. WATANABE Eizo (40375639)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
7. 菅井桂雄 (10187627)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SADAHIRO Tomohito (00436437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MORITA Yasumasa (20400971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OSHIMA Taku (50375789)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 上野博一 (70292688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 渡辺圭祐 (10375800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIGA Hidetoshi 志賀 英敏

志賀 英敏 シガ ヒデトシ

Research Projects

Research Products

Co-Researchers

Tailor-made therapy for patients with septic multiple organ failure using a cytokine adsorbing column based on genetic analysis of cytokine related gene polymorphisms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Predicting Onset of Secondary Multiple Organ Failure by Profiling of Cytokine Gene ExpressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNAマイクロアレイを用いた侵襲による生体反応に関する遺伝子分析と個別化治療

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TAILOR-MADE MEDICINE AGAINST PATHOPHYSIOLOGICAL RESPONSE TO STRESS BASED ON THE GENOME ANALYSIS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEVELOPMENT OF CYTOKINE ADSORPTION COLUMN AND THE TREATMENT OF MULTIPLE ORGAN FAILURE BY CYTOKINE ADSORPTION COLUMN

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cytokine modulation with continuous hemodiafiltration for treatment and prevention of multiple organ failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of a new Severity Scoring System for the Patients with Multiple Organ Failure from the Aspect of Cellular Injury - Anoxic Necrosis and Apoptosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Blood purification for hypercytokinemia.2006

Author(s)

Journal Title

Data Source

[Journal Article] Blood purification for hypercytokinemia.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Cytokine-related genotypic differences in peak interleukin-6 blood levels of patients with SIRS and septic complications.2005

Author(s)

Journal Title

Data Source

[Journal Article] Influence of toll-like receptor 4, CD14, tumor necrosis factor, and interleukine-10 gene polymorphisms on clinical outcome in Japanese critically ill patients.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Indication and perspective of acute blood purifications for the treatment of septic shock2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Cytokine-related genotypic differences in peak interleukin-6 blood levels of patients with SIRS and septic complications.2005

Author(s)

Journal Title

Data Source

[Journal Article] Sequential measurement of IL-6 blood levels in patients with systemic inflammatory response syndrome (SIRS) /sepsis.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Sequential measurement of IL-6 blood levels in patients with systemic inflammatory response syndrome (SIRS)/sepsis.2005

SHIGA Hidetoshi 志賀英敏

志賀英敏シガヒデトシ