Hara Nobumasa 原伸正

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HARA Nobumasa 原伸正

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Researcher Number	20284028
Other IDs
Affiliation (based on the past Project Information) *help	2023: 島根大学, 医学部, 特別協力研究員 2018 – 2022: 島根大学, 学術研究院医学・看護学系, 講師 2009 – 2011: Shimane University, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Food science
Keywords	Principal Investigator ポリ（ADP-リボース）ポリメラーゼ / NAD+代謝 / サーチュイン / ポリ(ADP-リボース)ポリメラーゼ / 老化 / CD38 / PARP-1 / ニコチンアミドホスホリボシルトランスフェラーゼ / ポリ（ADP-リボース)ポリメラーゼ / ニコチンアミドホスホリボシルトランスフェラーゼ … More / sirtuin / Nampt / NAD+ / 高脂血症薬 / 細胞死 / ストレス / 心筋細胞 / Sirt1 / NAD / ニコチン酸 Less

Identification of NAD+-degrading enzymes for the breakdown of NAD+ under the resting conditionsPrincipal Investigator
- Principal Investigator
  
  Hara Nobumasa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Shimane University
Transomic analysis of NAD+ metabolismPrincipal Investigator
- Principal Investigator
  
  Hara Nobumasa
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Shimane University
Cardioprotective effects of nicotinic acid via Sirt1 activationPrincipal Investigator
- Principal Investigator
  
  HARA Nobumasa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Shimane University

All 2024 2022 2021 2020 2019 2018 2011 2010 2009

All Journal Article Presentation

[Journal Article] The rate of NAD+ breakdown is maintained constant against deletion or overexpression of NAD+-degrading enzymes in mammalian cells2024
- Author(s)
  Nobumasa Hara, Harumi Osago, Mineyoshi Hiyoshi, and Mikiko Kobayashi-Miura
- Journal Title
  
  Journal of Nutritional Science and Vitaminology
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11696
[Journal Article] Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells2021
- Author(s)
  Takeshi Nakamura, Nobumasa Hara, Harumi Osago, Mineyoshi Hiyoshi, Mikiko Kobayashi-Miura, Mikako Tsuchiya
- Journal Title
  
  Shimane J. Med. Sci.
  
  Volume: 38 Pages: 59-66
- NAID
  130008119412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11696
[Journal Article] Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry.2019
- Author(s)
  Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 3 Pages: e0214000-e0214000
- DOI
  10.1371/journal.pone.0214000
- NAID
  120006882593
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01821, KAKENHI-PROJECT-17K00568, KAKENHI-PROJECT-18K11072, KAKENHI-PROJECT-19K09600
[Journal Article] Nicotinamide phospho-ribosyltransferase/Visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma2011
- Author(s)
  Hara N, Yamada K, Shibata T, Osago H, Tsuchiya M
- Journal Title
  
  PLoS ONE
  
  Volume: Vol 6, No.8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580139
[Journal Article] Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma2011
- Author(s)
  Nobumasa Hara
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580139
[Journal Article] Interferon-γelevates nicotinamide N-methyltransferase activity and nicotinamide level in human glioma cells2010
- Author(s)
  Yamada K, Miyazaki T, Hara N, Tsuchiya M
- Journal Title
  
  J. Nutr. Sci. Vitaminol
  
  Volume: Vol 56, No.2 Pages: 83-86
- NAID
  10026476527
- URL
  http://dx.doi.org/10.3177/jnsv.56.83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580139
[Presentation] Involvement of CD38 in NAD+ turnover in mammalian cells2022
- Author(s)
  Nobumasa Hara, Harumi Osago, Mineyoshi Hiyoshi, Mikiko Kobayashi-Miura
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K11696
[Presentation] Global acetylation levels of histone H4 lysine 16 and H3 lysine 9 may not represent cellular SIRT1 activity2021
- Author(s)
  Nobumasa Hara, Takeshi Nakamura, Harumi Osago, Mineyoshi Hiyoshi, Mikiko Kobayashi-Miura, Mikako Tsuchiya
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-21K11696
[Presentation] Global acetylation levels of histone H4 lysine 16 and H3 lysine 9 may not represent cellular SIRT1 activity2021
- Author(s)
  Nobumasa Hara, Takeshi Nakamura, Harumi Osago, Mineyoshi Hiyoshi, Mikiko Kobayashi-Miura, Mikako Tsuchiya
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-18K11072
[Presentation] NAD+分解におけるSARM1の関与について2020
- Author(s)
  原伸正、長子晴美、日吉峰麗、三浦美樹子、土屋美加子
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K11072
[Presentation] 哺乳動物初代培養細胞におけるNAD+代謝の解析2019
- Author(s)
  原　伸正、長子　晴美、日吉　峰麗、三浦　美樹子、土屋　美加子
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K11072
[Presentation] NAD+代謝におけるSIRT1の関与について2018
- Author(s)
  原伸正, 長子晴美, 日吉峰麗, 三浦美樹子, 土屋美加子
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K11072
[Presentation] ニコチン酸の薬理作用は細胞内NADレベルの増加を介するか?2011
- Author(s)
  原伸正, 山田和夫, 柴田朋子, 長子晴美, 土屋美加子
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都市)
- Data Source
  KAKENHI-PROJECT-21580139
[Presentation] LC/MS/MSを用いた細胞の酸処理による酸化および還元型NADPの同時定量法の確立2011
- Author(s)
  山田和夫, 原伸正, 長子晴美, 土屋美加子
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都市)
- Data Source
  KAKENHI-PROJECT-21580139
[Presentation] Visfatin/nicotinamide phosphoribosyltransferase dose not function as an extracellular NAD synthetic enzyme2010
- Author(s)
  原伸正
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21580139
[Presentation] Visfatin/nicotinamide phosphoribosyltransferase does not function as an extracellular NAD synthetic enzyme2010
- Author(s)
  Hara N, Yamada K, Osago H, Shibata T, Tsuchiya M
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸国際展示場(神戸市)
- Data Source
  KAKENHI-PROJECT-21580139
[Presentation] 質量分析によるNADH酸分解産物を用いたNADH定量法とこの方法の細胞の酸化還元状態の解析への応用の検討2010
- Author(s)
  山田和夫, 原伸正, 長子晴美, 柴田朋子, 土屋美加子
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸国際展示場(神戸市)
- Data Source
  KAKENHI-PROJECT-21580139
[Presentation] Quantitative determination of NAD turnover using deuterium-labeled nicotinamide and nicotinic acid2009
- Author(s)
  原伸正, 山田和夫, 柴田朋子, 長子晴美, 土屋美加子
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(神戸市)
- Data Source
  KAKENHI-PROJECT-21580139
[Presentation] (招待講演) Elevation of Cellular NAD Levels by Nicotinic Acid and Involvement of Nicotinic Acid Phosphoribosyltransferase in Human cells2009
- Author(s)
  Hara N, Yamada K, Shibata K, Osago H, Tsuchiya M
- Organizer
  NAD METABOLISM AND SIGNALING
- Place of Presentation
  CAREFREE, ARIZONA, USA
- Data Source
  KAKENHI-PROJECT-21580139
[Presentation] Quantitative determination of NAD turnover using deuterium-labeled nicotinamide and nicotinic aced2009
- Author(s)
  原伸正
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21580139
[Presentation] Elevation of Cellular NAD Levels by Nicotinic Acid and Involvement of Nicotinic Acid Phosphoribosyltransferase in Human Cells2009
- Author(s)
  Hara N.(招待講演)
- Organizer
  NAD METABOLISM AND SIGNALING
- Place of Presentation
  CAREFREE, ARIZONA
- Data Source
  KAKENHI-PROJECT-21580139

1. MIURA Mikiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Nobumasa 原 伸正

HARA Nobumasa 原 伸正

Research Projects

Research Products

Co-Researchers

Identification of NAD+-degrading enzymes for the breakdown of NAD+ under the resting conditionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Transomic analysis of NAD+ metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cardioprotective effects of nicotinic acid via Sirt1 activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The rate of NAD+ breakdown is maintained constant against deletion or overexpression of NAD+-degrading enzymes in mammalian cells2024

Author(s)

Journal Title

Data Source

[Journal Article] Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Nicotinamide phospho-ribosyltransferase/Visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma2011

Author(s)

Journal Title

Data Source

[Journal Article] Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma2011

Author(s)

Journal Title

Data Source

[Journal Article] Interferon-γelevates nicotinamide N-methyltransferase activity and nicotinamide level in human glioma cells2010

Author(s)

Journal Title

NAID

URL

Data Source

[Presentation] Involvement of CD38 in NAD+ turnover in mammalian cells2022

Author(s)

Organizer

Data Source

[Presentation] Global acetylation levels of histone H4 lysine 16 and H3 lysine 9 may not represent cellular SIRT1 activity2021

Author(s)

Organizer

Data Source

[Presentation] Global acetylation levels of histone H4 lysine 16 and H3 lysine 9 may not represent cellular SIRT1 activity2021

Author(s)

Organizer

Data Source

[Presentation] NAD+分解におけるSARM1の関与について2020

Author(s)

Organizer

Data Source

[Presentation] 哺乳動物初代培養細胞におけるNAD+代謝の解析2019

Author(s)

Organizer

Data Source

[Presentation] NAD+代謝におけるSIRT1の関与について2018

Author(s)

Organizer

Data Source

[Presentation] ニコチン酸の薬理作用は細胞内NADレベルの増加を介するか?2011

Author(s)

Organizer

Place of Presentation

Hara Nobumasa 原伸正

HARA Nobumasa 原伸正