Kawakubo Hirofumi 川久保博文

… Alternative Names

KAWAKUBO Hirofumi 川久保博文

Hirofumi Kawakubo 川久保博文

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Researcher Number	20286496
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 慶應義塾大学, 医学部(信濃町), 准教授 2017 – 2018: 慶應義塾大学, 医学部(信濃町), 准教授 2016: 慶應義塾大学, 医学部(信濃町), 講師 2013 – 2015: 慶應義塾大学, 医学部, 講師 2000: Keio University, Department of Surgery, Assistant, 医学部, 助手 1999 – 2000: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor diagnostics / Tumor therapeutics Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Digestive surgery
Keywords	Principal Investigator 食道癌 / 薬剤耐性 / 放射線耐性遺伝子 / 抗癌剤耐性遺伝子 / トランスポゾン / 放射線耐性 / 治療抵抗性 / 集学的治療 / マルチオミックス / 炎症凝固 … More / 薬剤反応性 / 遺伝子 / 癌 / 5FU / 放射線療法 / 薬剤耐性遺伝子 / 化学療法 / 放射線 / シスプラチン / 5-FU / 網羅的解析 / 5FU耐性遺伝子 / シスプラチン耐性遺伝子 / JAK2 / シスプラチン耐性 / 網羅的遺伝子解析 / 抗癌剤耐性 … More Except Principal Investigator プレシジョンメディシン / クリニカルシーケンス / 遺伝子発現 / がんゲノム / 癌ゲノム医療 / オミックスデータ解析 / 医療情報の構造化 / 医学用語の構造化 / 自然言語処理 / オミックスデータ / バイオインフォマティクス / がんゲノム医療 / FGF / 血管新生 / RNase / VEGF / 血管新生阻害剤 / 生理活性物質 / 食道癌 Less

Overcoming the drug resistance through drug repositioning in esophageal cancerPrincipal Investigator
- Principal Investigator
  
  川久保博文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Keio University
Overcoming the drug resistance through muti-omics analysis in esophageal cancerPrincipal Investigator
- Principal Investigator
  
  KAWAKUBO Hirofumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Keio University
Construction of platform for clinical application of cancer omics data
- Principal Investigator
  
  KITAGAWA Yuko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Keio University
The Novel and Comprehensive Screening of Genes Resistant to an Anticancer Drug and Radiation in Esophageal Squamous Cell CarcinomaPrincipal Investigator
- Principal Investigator
  
  Kawakubo Hirofumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Keio University
The novel and comprehensive screening of genes resistant to an anticancer drug and radiation in esophageal squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  Hirofumi Kawakubo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Keio University
Research of recombinant human RNase fused protein on angiogenesis and tumor growth
- Principal Investigator
  
  OZAWA Soji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Keio University

All 2022 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Elevation of the Prognostic Factor Plasma Fibrinogen Reflects the Immunosuppressive Tumor Microenvironment in Esophageal Squamous Cell Carcinoma2022
- Author(s)
  Hoshino Shota、Matsuda Satoru、Kawakubo Hirofumi、Yamaguchi Shigeo、Nakamura Kohei、Aimono Eriko、Matsui Kazuaki、Irino Tomoyuki、Fukuda Kazumasa、Nakamura Rieko、Okita Hajime、Nishihara Hiroshi、Takeuchi Hiroya、Kitagawa Yuko
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 29 Issue: 11 Pages: 6894-6904
- DOI
  10.1245/s10434-022-11974-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07664
[Journal Article] Downregulation of cytochrome c oxidase 1 induced radioresistance in esophageal squamous cell carcinoma.2017
- Author(s)
  Takesue T, Kawakubo H, Hayashida T, Tsutsui M, Miyao K, Fukuda K, Nakamura R, Takahashi, , Wada N, Takeuchi H, Kitagawa Y
- Journal Title
  
  Oncology letter
  
  Volume: 14(4) Issue: 4 Pages: 4220-4224
- DOI
  10.3892/ol.2017.6699
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07149
[Journal Article] Comprehensive screening of genes resistant to an anticancer drug in esophageal squamous cell carcinoma2015
- Author(s)
  Tsutsui M, Kawakubo H,Hayashida T, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Takeuchi H, Kitagawa Y
- Journal Title
  
  International Journal of Oncology
  
  Volume: 47 Pages: 867-874
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25430159
[Presentation] The novel and comprehensive screening of genes resistant to an anticancer drug and radiation in esophageal squamous cell carcinoma2016
- Author(s)
  Hirofumi Kawakubo
- Organizer
  2016 AACR Annual Meeting
- Place of Presentation
  New Orleans, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07149
[Presentation] 食道癌抗癌剤耐性遺伝子としてJAK2遺伝子の検討2015
- Author(s)
  気賀澤悠，川久保博文，福田和正，中村理恵子，高橋常浩,和田則仁，竹内裕也，北川雄光
- Organizer
  第26回日本消化器癌発生学会総会
- Place of Presentation
  米子全日空ホテル（鳥取県米子市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25430159
[Presentation] トランスポゾンを用いた食道癌薬剤耐性遺伝子の網羅的解析法
- Author(s)
  筒井麻衣，川久保博文，林田哲，福田和正，竹内裕也，北川雄光
- Organizer
  第68回日本食道学会学術集会
- Place of Presentation
  東京都文京区，東京ドームホテル
- Year and Date
  2014-07-03 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-25430159
[Presentation] トランスポゾンを用いた網羅的遺伝子解析による食道癌放射線耐性遺伝子の同定
- Author(s)
  武居友子，川久保博文，林田哲，福田和正，中村理恵子，高橋常浩，和田則仁，竹内裕也，才川義朗，大森泰，北川雄光
- Organizer
  第52回日本癌治療学会学術集会
- Place of Presentation
  神奈川県横浜市，パシフィコ横浜
- Year and Date
  2014-08-28 – 2014-08-30
- Data Source
  KAKENHI-PROJECT-25430159
[Presentation] The Novel Comprehensive Screening of Anticancer Drug Resist Genes of Esophageal Cancer.
- Author(s)
  Tsutsui M, Kawakubo H, Hayashida T, Fukuda K, Takeuchi H, Kitagawa Y.
- Organizer
  14th World Congress of International Society for Diseases of the Esophagus (ISDE)
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2014-09-22 – 2014-09-25
- Data Source
  KAKENHI-PROJECT-25430159
[Presentation] トランスポゾンを用いた、薬剤耐性遺伝子の網羅的解析法
- Author(s)
  筒井麻衣、川久保博文、林田哲、福田和正、竹内裕也、北川雄光
- Organizer
  第22回日本がん転移学会学術集会・総会
- Place of Presentation
  長野県，ブエナビスタ松本
- Data Source
  KAKENHI-PROJECT-25430159

1. 松田諭 (30594725)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. HAYASHIDA Tetsu (80327543)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. TSUTSUI Mai (90573460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. OZAWA Soji (10169287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MORI Katsuaki (40286505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KITAGAWA Yuko (20204878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 岡林剛史 (00338063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 北郷実 (70296599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 阿部雄太 (70327526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 信末博行 (90525685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kawakubo Hirofumi 川久保 博文

KAWAKUBO Hirofumi 川久保 博文

Hirofumi Kawakubo 川久保 博文

Research Projects

Research Products

Co-Researchers

Overcoming the drug resistance through drug repositioning in esophageal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Overcoming the drug resistance through muti-omics analysis in esophageal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of platform for clinical application of cancer omics data

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The Novel and Comprehensive Screening of Genes Resistant to an Anticancer Drug and Radiation in Esophageal Squamous Cell CarcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The novel and comprehensive screening of genes resistant to an anticancer drug and radiation in esophageal squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of recombinant human RNase fused protein on angiogenesis and tumor growth

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Elevation of the Prognostic Factor Plasma Fibrinogen Reflects the Immunosuppressive Tumor Microenvironment in Esophageal Squamous Cell Carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Downregulation of cytochrome c oxidase 1 induced radioresistance in esophageal squamous cell carcinoma.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive screening of genes resistant to an anticancer drug in esophageal squamous cell carcinoma2015

Author(s)

Journal Title

Data Source

[Presentation] The novel and comprehensive screening of genes resistant to an anticancer drug and radiation in esophageal squamous cell carcinoma2016

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 食道癌抗癌剤耐性遺伝子としてJAK2遺伝子の検討2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] トランスポゾンを用いた食道癌薬剤耐性遺伝子の網羅的解析法

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] トランスポゾンを用いた網羅的遺伝子解析による食道癌放射線耐性遺伝子の同定

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The Novel Comprehensive Screening of Anticancer Drug Resist Genes of Esophageal Cancer.

Kawakubo Hirofumi 川久保博文

KAWAKUBO Hirofumi 川久保博文

Hirofumi Kawakubo 川久保博文