Takenouchi Takato 竹之内敬人

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TAKENOUCHI Takato 竹之内敬人

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Researcher Number	20292518
Other IDs
Affiliation (Current)	2025: 国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門, グループ長
Affiliation (based on the past Project Information) *help	2023 – 2025: 国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門, グループ長 2018: 国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門, 主席研究員 2017: 国立筑波農業資源研究所, 主任研究員 2016 – 2017: 国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門動物機能利用研究領域, 主席研究員 2015: 国立研究開発法人農業生物資源研究所, 動物生体防御研究ユニット, 上級研究員 … More 2015: 国立研究開発法人農業生物資源研究所, 動物生体防御研究ユニット, 主任研究員 2011 – 2014: 独立行政法人農業生物資源研究所, 動物生体防御研究ユニット, 主任研究員 2010: 独立行政法人農業生物資源研究所, 遺伝子組換え家畜研究センター, 主任研究員 2008: National Institute of Agrobiological Sciences, 遺伝子組換え家畜研究センター, 主任研究員 2007: National Institute of Agrobiological Sciences, 遺伝子組換え家畜研究センター, 主任研究員 2006: 独立行政法人農業生物資源研究所, 遺伝子組換え家畜研究センター, 主任研究員 Less
Review Section/Research Field	Principal Investigator Applied molecular and cellular biology / Basic Section 42030:Animal life science-related / Applied biochemistry Except Principal Investigator Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Neurochemistry/Neuropharmacology / Animal production science / Neurophysiology and muscle physiology
Keywords	Principal Investigator 非典型的分泌機構 / マクロファージ / P2X7受容体 / 日本脳炎ウイルス / 豚繁殖・呼吸障害症候群ウイルス / アフリカ豚熱ウイルス / 宿主-病原体相互作用 / アカカワイノシシマクロファージ / 細胞応答 / 神経調節因子 … More / 自然免疫応答 / エキソソーム / GAPDH / アラーミン / P2×7受容体 / P2X7 受容体 / ミクログリア / プリオン / 平滑筋細胞 / 内皮細胞 / ウシ細胞株 / プリオン蛋白質 / 神経前駆細胞 / 新規ウシ細胞株 / ウシプリオン蛋白 / BSE / プリオン蛋白 / 神経様細胞株 / 内皮細胞様細胞株 / ウシ脳由来細胞株 … More Except Principal Investigator 多型 / ブタ / 視床下部 / 酸化ストレス / ドーパミン / 黒質 / 慢性ストレス / 青斑核 / ノルアドレナリン / ストレス / ミクログリア / 腸-肺軸 / ウイルス / パターン認識受容体 / ポストイムノバイオティクス / 鬱病 / 交感神経系 / 腹側被蓋野 / パーキンソン病 / マクロファージ / プロモータ / マイクロアレイ / 育種 / 選抜 / 免疫 / 抗病性 / 感染症 / 脳内炎症 / 副腎ステロイド / 海馬 / 神経科学 / 神経免疫 / ニトロタイロシン / 脳内免疫 / アドレナリン受容体 Less

Development of in vitro models for analysis of livestock pathogens using a red river hog macrophage cell linePrincipal Investigator
- Principal Investigator
  
  竹之内敬人
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  National Agriculture and Food Research Organization
家畜健全育成向上戦略：イムノバイオティクスと自然免疫受容体の腸-肺軸シンフォニー
- Principal Investigator
  
  北澤春樹
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Tohoku University
The role of neuromodulatory factors in innate immune systemPrincipal Investigator
- Principal Investigator
  
  TAKENOUCHI Takato
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  National Agriculture and Food Research Organization
Investigation of microglia and chronic stress in the onset of Parkinson disease
- Principal Investigator
  
  Sugama Shuei
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Nippon Medical School
Elucidation of genetic change associated with selection of immune competence in swine
- Principal Investigator
  
  Shinkai Hiroki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Animal production science
- Research Institution
  National Institute of Agrobiological Sciences
Secretome analysis for the search for novel danger signal alarmins in ATP-stimulated macrophagesPrincipal Investigator
- Principal Investigator
  
  TAKENOUCHI Takato
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  National Institute of Agrobiological Sciences
Investigation of microglial activation through noradrenaline in the process of neurodegenerative disease
- Principal Investigator
  
  SUGAMA Shuei
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Nippon Medical School
Study on the molecular mechanisms of prion secretion from microglial cellsPrincipal Investigator
- Principal Investigator
  
  TAKENOUCHI Takato
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  National Institute of Agrobiological Sciences
Establishment and characterization of immortalized cell lines derived from bovine brain tissuesPrincipal Investigator
- Principal Investigator
  
  TAKENOUCHI Takato
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  National Institute of Agrobiological Sciences

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book

[Book] EMERGING DRUGS AND TARGETS FOR PARKINSON´S DISEASE2014
- Author(s)
  Takenouchi T, Sekiyama K, Sugama S, Iwamaru Y, Kitani H, Hashimoto M
- Total Pages
  402
- Publisher
  RSC publishing
- Data Source
  KAKENHI-PROJECT-25450521
[Book] Role of autophagy in P2X7 receptor-mediated maturation and unconventional secretion of IL-1β in microglia. AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection2013
- Author(s)
  Takenouchi T, Sekiyama K, Tsukimoto M, Iwamaru Y, Fujita M, Sugama S, Kitani H, Hashimoto M.
- Publisher
  Elsevier (in press)
- Data Source
  KAKENHI-PROJECT-22580389
[Book] AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection (CHAPTER: ROLE OF AUTOPHAGY IN P2X7 RECEPTOR-MEDIATED MATURATION AND UNCONVENTIONAL SECRETION OF IL-1β IN MICROGLIA)2013
- Author(s)
  Takenouchi T, Sekiyama K, Tsukimoto M, Iwamaru Y, Fujita M, Sugama S, Kitani H, Hashimoto M
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-22580389
[Journal Article] Evolvability of amyloidogenic proteins in human brain2018
- Author(s)
  Hashimoto M, Ho G, Sugama S, Takamatsu Y, Shimizu Y, Takenouchi T, Waragai M, Masliah E
- Journal Title
  
  J Alzheimers Dis
  
  Volume: 62 Issue: 1 Pages: 73-83
- DOI
  10.3233/jad-170894
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783
[Journal Article] Potential application of centrifuges to protect the CNS in space and on earth2018
- Author(s)
  Hashimoto M, Ho G, Shimizu Y, Sugama S, Takenouchi T, Waragai M, Wei J, Takamatsu Y
- Journal Title
  
  Curr Alzheimer Res
  
  Volume: 15 Issue: 6 Pages: 544-551
- DOI
  10.2174/1567205015666171229225501
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783
[Journal Article] Importance of adiponectin activity in the pathogenesis of Alzheimer's disease2017
- Author(s)
  Waragai M, Ho G, Takamatsu Y, Sekiyama K, Sugama S, Takenouchi T, Masliah E, Hashimoto M
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume: 4 Issue: 8 Pages: 591-600
- DOI
  10.1002/acn3.436
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-15K09820
[Journal Article] Immortalization and Characterization of Porcine Macrophages That Had Been Transduced with Lentiviral Vectors Encoding the SV40 Large T Antigen and Porcine Telomerase Reverse Transcriptase2017
- Author(s)
  Takenouchi Takato、Kitani Hiroshi、Suzuki Shunichi、Nakai Michiko、Fuchimoto Dai-ichiro、Tsukimoto Mitsutoshi、Shinkai Hiroki、Sato Mitsuru、Uenishi Hirohide
- Journal Title
  
  Frontiers in Veterinary Science
  
  Volume: 4 Pages: 1-9
- DOI
  10.3389/fvets.2017.00132
- NAID
  120006626771
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08148
[Journal Article] マクロファージの簡便な大量回収法とその利用2016
- Author(s)
  竹之内敬人、吉岡都、木谷裕、山中典子
- Journal Title
  
  ケミカルエンジニヤリング
  
  Volume: 61 Pages: 510-515
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08148
[Journal Article] Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson's disease2016
- Author(s)
  Sugama S, Sekiyama K, Kodama T, Takamatsu Y, Takenouchi T, Hashimoto M, Conti B, Kakinuma Y
- Journal Title
  
  Brain Behav Immun
  
  Volume: 51 Pages: 39-46
- DOI
  10.1016/j.bbi.2015.08.015
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-25460333, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-16K08560
[Journal Article] Combined immunotherapy with “anti-insulin resistance” therapy as a novel therapeutic strategy against neurodegenerative diseases.2016
- Author(s)
  Takamatsu Y, Ho G, Koike W, Sugama S, Takenouchi T, Waragai M, Wei J, Sekiyama K, Hashimoto M.
- Journal Title
  
  npj Parkinson’s Disease
  
  Volume: 3 Issue: 1 Pages: 4-4
- DOI
  10.1038/s41531-016-0001-1
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-15K06783
[Journal Article] Extracellular ATP induces unconventional release of glyceraldehyde-3-phosphate dehydrogenase from microglial cells2015
- Author(s)
  Takenouchi T, Tsukimoto M, Iwamaru Y, Sugama S, Sekiyama K, Sato M, Kojima S, Hashimoto M, Kitani H
- Journal Title
  
  Immunol Lett
  
  Volume: 167 Issue: 2 Pages: 116-124
- DOI
  10.1016/j.imlet.2015.08.002
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-25450521
[Journal Article] ATP-triggered unconventional secretion of GAPDH from macrophages: Its putative role as a modulator of inflammation.2015
- Author(s)
  Takenouchi T., Tsukimoto M., Hashimoto M., Kitani H.
- Journal Title
  
  Macrophage
  
  Volume: 2
- DOI
  10.14800/macrophage.1083
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25450521
[Journal Article] Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death.2015
- Author(s)
  Toki Y, Takenouchi T, Harada H, Tanuma S, Kitani H, Kojima S, Tsukimoto M.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 458(4) Issue: 4 Pages: 771-776
- DOI
  10.1016/j.bbrc.2015.02.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590125, KAKENHI-PROJECT-25450521, KAKENHI-PROJECT-25460156, KAKENHI-PROJECT-25290019
[Journal Article] Purinergic signaling via P2Y receptors up-mediates IL-6 production by liver macrophages/Kupffer cells2014
- Author(s)
  Ishimaru M, Yusuke N, Tsukimoto M, Harada H, Takenouchi T, Kitani H, Kojima S
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 39 Pages: 413-423
- NAID
  130004447125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450521
[Journal Article] Extracellular ATP does not induce P2X7 receptor-dependent responses in cultured renal- and liver-derived swine macrophages2014
- Author(s)
  Takenouchi T, Suzuki S, Shinkai H, Tsukimoto M, Sato M, Uenishi H, Kitani H
- Journal Title
  
  Results in Immunology
  
  Volume: 4 Pages: 62-67
- DOI
  10.1016/j.rinim.2014.07.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25450521
[Journal Article] Disease-Modifying Effect of Adiponectin in Model of a-Synucleinopathies2014
- Author(s)
  Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada AR, Masliah E, Hashimoto M
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume: 1 Pages: 479-489
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500465
[Journal Article] Inflammasome activation by danger signals: extracellular ATP and pH2014
- Author(s)
  Takenouchi T, Tsukimoto M, Hashimoto M, Kitani H
- Journal Title
  
  Inflammasome
  
  Volume: 1 Issue: 1 Pages: 76-80
- DOI
  10.2478/infl-2014-0008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25450521
[Journal Article] Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle2014
- Author(s)
  Kojima S, Negishi Y, Tsukimoto M, Takenouchi T, Kitani H, Takeda K
- Journal Title
  
  Toxicology
  
  Volume: 321 Pages: 13-20
- DOI
  10.1016/j.tox.2014.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450521
[Journal Article] Cytochalasin D enhances the accumulation of a protease-resistant form of prion protein in ScN2a Cells: Involvement of PI3 kinase/Akt signaling pathway.2012
- Author(s)
  Takenouchi T. et al.
- Journal Title
  
  Cell Biol. Int.
  
  Volume: 36 Issue: 12 Pages: 1223-1231
- DOI
  10.1042/cbi20120329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390040, KAKENHI-PROJECT-22580389, KAKENHI-PROJECT-24500465, KAKENHI-PLANNED-22113009
[Journal Article] Ibuprofen ameliorates protein aggregation and astrocytic gliosis, but not cognitive dysfunction, in a transgenic mouse expressing dementia with Lewy bodies-linked P123H b-synuclein2012
- Author(s)
  S ekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Waragai M, Takenouchi T, Sugama S, Hashimoto M
- Journal Title
  
  Neurosci Lett
  
  Volume: 515(1) Issue: 1 Pages: 97-101
- DOI
  10.1016/j.neulet.2012.03.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359, KAKENHI-PROJECT-21700399, KAKENHI-PROJECT-24500465, KAKENHI-PUBLICLY-24111555
[Journal Article] Corticosteroids limit microglial activation occurring during acute stress2012
- Author(s)
  Sugama S, Takenouchi T, Fujita M, Kitani H, Conti B, Hashimoto M
- Journal Title
  
  Neuroscience
  
  Volume: 232 Pages: 13-20
- DOI
  10.1016/j.neuroscience.2012.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500465
[Journal Article] Anti-prion activity of Brilliant Blue G.2012
- Author(s)
  Iwamaru Y*, Takenouchi T*, Murayama Y, Okada H,Imamura M, Shimizu Y, Hashimoto M, Mohri S, Yokoyama T, Kitani H.
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 5 Pages: 37896-37896
- DOI
  10.1371/journal.pone.0037896
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580389, KAKENHI-PROJECT-23780313
[Journal Article] Cold stress induced morphological microglial activation and increased IL-1β expression in astroglial cells in rat brain2011
- Author(s)
  Sugama S, Takenouchi T, Fujita M, Kitani H, Hashimoto M
- Journal Title
  
  J.Neuroimmunol
  
  Volume: 233巻 Pages: 29-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580389
[Journal Article] The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1b under acidic extracellular pH in LPS-primed microglial cells2011
- Author(s)
  T akenouchi T, Iwamaru Y, Sugama S, Tsukimoto M, Fujita M, Sekigawa A, Sekiyama K, Sato M, Kojima S, Conti B, Hashimoto M, Kitani H
- Journal Title
  
  J. Neurochem
  
  Volume: 117 Pages: 712-723
- DOI
  10.1111/j.1471-4159.2011.07240.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359, KAKENHI-PROJECT-21700399, KAKENHI-PROJECT-22580389
[Journal Article] Reversible conversion of epithelial and mesenchymal phenotypes in SV40 large T antigen-immortalized rat liver cell lines2010
- Author(s)
  Takenouchi T, Yoshioka M, Yamanaka N, Kitani H.
- Journal Title
  
  Cell Biol. Int. Rep
  
  Volume: 17 Issue: 1 Pages: 1-1
- DOI
  10.1042/cbr20100001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580389
[Journal Article] Reversible conversion of epithelial and mesenchymal phenotypes in SV40 large Tantigen-immortalized rat liver cell lines2010
- Author(s)
  Takenouchi T, Yoshioka M, Yamanaka N, Kitani H
- Journal Title
  
  Cell Biol.Int.Rep
  
  Volume: 17巻
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580389
[Journal Article] Establishment of an SV40 large T antigen-immortalized bovine brain cell line and its neuronal differentiation by dibutyryl cyclic AMP.2009
- Author(s)
  Takenouchi T., Iwamaru Y., Sato M.,Yokoyama T., Kitani H
- Journal Title
  
  Cell Biol. Int 33
  
  Pages: 187-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780081
[Journal Article] Establishment of an SV40 large T antigen-immortalized bovine brain cell line and its neuronal differentiation by dibutyryl cyclic AMP.2009
- Author(s)
  Takenouchi T, Iwamaru Y, Sato M, Yokoyama T, Kitani H
- Journal Title
  
  Cell Biol. Int. 33
  
  Pages: 187-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780081
[Journal Article] The activation of P2X7 receptor impairs lysosomal functions and stimulates the release of autophagolysosomes in microglial cells.2009
- Author(s)
  Takenouchi T., Nakai M., Iwamaru Y.,Sugama S., Tsukimoto M., Fujita M., Wei J.,Sekigawa A., Sato M., Kojima S., Kitani H.,and Hashimoto M.
- Journal Title
  
  J. Immunol 182
  
  Pages: 2051-2062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780081
[Journal Article] The activation of P2X7 receptor impairs lysosomal functions and stimulates the release of autophagolysosomes in microglial cells.2009
- Author(s)
  Takenouchi T., Nakai M., Iwamaru Y., Sugama S., Tsukimoto M., Fujita M., Wei J., Sekigawa A., Sato M., Kojima S., Kitani H., Hashimoto M.
- Journal Title
  
  J. Immunol. 182
  
  Pages: 2051-2062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780081
[Journal Article] ミクログリア細胞株を用いたプリオン持続感染モデル系の作出とその特性解析2008
- Author(s)
  竹之内敬人、岩丸祥史、横山隆、木谷裕,
- Journal Title
  
  生化学 80巻7号
- NAID
  10021924827
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780081
[Journal Article] Lysophospholipids and ATP mutually suppress maturation and release of IL-1β in mouse microglial cells using a Rho-dependent pathway.2008
- Author(s)
  Takenouchi T., Iwamaru Y., Sugama S., Sato M., Hashimoto M., Kitani H.
- Journal Title
  
  J. Immunol. 180
  
  Pages: 7827-7839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780081
[Journal Article] Lysophospholipids and ATP mutually suppress maturation and release of IL-1υ in mouse microglial cells using a Rho-dependent pathway.2008
- Author(s)
  Takenouchi T., Iwamaru Y., Sugama S., Sato M., Hashimoto M., and Kitani H.
- Journal Title
  
  J. Immunol. 180
  
  Pages: 7827-7839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780081
[Journal Article] Prion infection correlates with hypersensitivity of P2X7 nucleotide receptor in amouse microglial cell line.2007
- Author(s)
  Takenouchi T, Iwamaru Y, Imamura M, Kato N, Sugama S, Fujita M, Hashimoto M, Sato M, Okada H, Yokoyama T, Mohri S, Kitani H.
- Journal Title
  
  FEBS Lett. 581
  
  Pages: 3019-3026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780081
[Journal Article] Lysophosphatidylcholine potentiates Ca^<2+> influx, pore formation and p44/42 MAP kinase phosphorylation mediated by P2X7 receptor activation in mouse microglial cells.2007
- Author(s)
  Takenouchi T., Sato M., Kitani H.
- Journal Title
  
  J. Neurochem. 102
  
  Pages: 1518-1532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780081
[Journal Article] Establishment and characterization of SV40large T antigen-immortalized cell lines derived from fetal bovine brain tissues after prolonged cryopreservation2007
- Author(s)
  Takenouchi T, Iwamaru Y, Sato M, Yokoyama T, Shinagawa M, Kitani H
- Journal Title
  
  Cell Biology International 31(1)
  
  Pages: 57-64
- Data Source
  KAKENHI-PROJECT-18780081
[Journal Article] Prion infection correlates with hypersensitivity of P2X7 nucleotide receptor in a mouse microglial cell line.2007
- Author(s)
  Takenouchi T., Iwamaru Y., Imamura M., Kato N., Sugama S., Fujita M., Hashimoto M., Sato M., Okada H., Yokoyama T., Mohri S, Kitani H
- Journal Title
  
  FEBS Lett. 581
  
  Pages: 3019-3026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780081
[Journal Article] Establishment and characterization of SV40 large T antigen-immortalized cell lines derived from fetal bovine brain tissues after prolonged cryopreservation.2007
- Author(s)
  Takenouchi T., Iwamaru Y., Sato M., Yokoyama T., Shinagawa M., Kitani H.
- Journal Title
  
  Cell Biol. Int 31
  
  Pages: 57-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780081
[Journal Article] Lysophosphatidylcholine potentiates Ca^2+ influx, pore formation and p44/42 MAP kinase phosphorylation mediated by P2X7 receptor activation in mouse microglial cells.2007
- Author(s)
  Takenouchi T, Sato M, Kitani H.
- Journal Title
  
  J. Neurochem. 102
  
  Pages: 1518-1532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780081
[Presentation] 腎マクロファージにおけるP2X7受容体活性化による免疫調節因子の放出2018
- Author(s)
  箱田公樹、竹之内敬人、木谷裕、月本光俊
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08148
[Presentation] ブタマクロファージ不死化細胞株の樹立と特性解析2018
- Author(s)
  竹之内敬人、木谷裕、鈴木俊一、中井美智子、淵本大一郎、月本光俊、新開浩樹、佐藤充、上西博英
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-16K08148
[Presentation] 腎マクロファージにおけるP2X7受容体活性化による免疫調節因子の放出2017
- Author(s)
  箱田公樹、竹之内敬人、木谷裕、月本光俊
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08148
[Presentation] ミクログリアにおけるGAPDHの非典型的放出機構と自然免疫応答調節2016
- Author(s)
  竹之内敬人, 月本光俊, 佐藤充, 木谷裕
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌
- Year and Date
  2016-03-30
- Data Source
  KAKENHI-PROJECT-25450521
[Presentation] ブタの免疫能選抜により生じた遺伝的特性変化の解明2016
- Author(s)
  新開浩樹・高萩陽一・松本敏美・土岐大輔・竹之内敬人・木谷裕・鈴木啓一・上西博英
- Organizer
  日本畜産学会第121回大会
- Place of Presentation
  日本獣医生命科学大学
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26850173
[Presentation] ブタ腎臓および肝臓マクロファージの単離・培養とP2X7受容体機能解析2015
- Author(s)
  竹之内敬人, 鈴木俊一, 新開浩樹, 月本光俊, 佐藤充, 上西博英, 木谷裕
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-25450521
[Presentation] プリオン感染N2a細胞での異常プリオン蛋白蓄積におけるアクチン骨格及びPI3キナーゼ経路の関与2013
- Author(s)
  竹之内敬人,岩丸祥史,今村守一,佐藤充,横山隆,毛利資郎,木谷裕
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台
- Year and Date
  2013-03-26
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] P2X7 receptor-mediated pathways2012
- Author(s)
  Takenouchi T, Iwamaru Y, Tsukimoto M, Sato M, Kojima S, Hashimoto M, Kitani H.
- Organizer
  involved in the production and release of a 20-kDa form of IL-1β from LPS-primed microglial cells. Purine 2012
- Place of Presentation
  福岡
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] P2X7 receptor-mediated pathways involved in the production and release of a 20-kDa form of IL-1β from LPS-primed microglial cells.2012
- Author(s)
  Takenouchi T, Iwamaru Y, Tsukimoto M, Sato M, Kojima S, Hashimoto M, Kitani H
- Organizer
  Purine 2012
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] Brilliant blue G, an antagonist of the ATP sensitive receptor P2X7 prevents prion accumulation2011
- Author(s)
  Iwamaru Y, Takenouchi T, Imamura M, Shimizu Y, Murayama Y, Mohri S, Yokoyama T, Kitani H
- Organizer
  Prion 2011
- Place of Presentation
  モントリオール、カナダ
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] Brilliant blue G2011
- Author(s)
  Iwamaru Y, Takenouchi T, Imamura M, Shimizu Y, Murayama Y, Mohri S, Yokoyama T, Kitani H.
- Organizer
  an antagonist of the ATP sensitive receptor P2X7 prevents prion accumulation. Prion 2011
- Place of Presentation
  モントリオール、カナダ
- Year and Date
  2011-05-17
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] Anti-prion activity of Brilliant blue G, an antagonist of the ATP-sensitive receptor P2X72011
- Author(s)
  Iwamaru Y, Takenouchi T, Imamura M, Shimizu Y, Murayama Y, Mohri S, Yokoyama T, Kitani H
- Organizer
  Asian Pacific Prion Symposium 2011
- Place of Presentation
  軽井沢
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] P2X7受容体活性化に伴うミクログリアからの20-kDa IL-1βフラグメントの産生機構2011
- Author(s)
  竹之内敬人、岩丸祥史、洲鎌秀永、月本光俊、佐藤充、小島周二、橋本款、木谷裕
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] P2X7受容体活性化に伴うミクロクリアからの20-kDa IL-1βフラグメントの産生機構2011
- Author(s)
  竹之内敬人、岩丸祥史、洲鎌秀永、月本光俊、佐藤充、小島周二、橋本款、木谷裕
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] Anti-prion activityof Brilliant blue G2011
- Author(s)
  Iwamaru Y, Takenouchi T, Imamura M, Shimizu Y, Murayama Y, Mohri S, Yokoyama T, Kitani H.
- Organizer
  an antagonist of the ATP-sensitive receptor P2X7. Asian Pacific Prion Symposium 2011
- Place of Presentation
  軽井沢
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] P2X7受容体阻害剤Brilliant Blue Gは持続感染細胞におけるプリオン増殖を阻害する2010
- Author(s)
  岩丸祥史, 竹之内敬人, 清水善久, 今村守一, 村山裕一, 横山隆, 木谷裕
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  ホートアイランド(神戸)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] P2X7受容体阻害剤Brilliant Blue Gは持続感染細胞におけるプリオン増殖を阻害する2010
- Author(s)
  岩丸祥史,竹之内敬人,清水善久,今村守一,村山裕一,横山隆,木谷裕
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] ミクログリアでのATPによる成熟型インターロイキシ-1β産生に対するリゾリン脂質の効果2009
- Author(s)
  竹之内敬人,木谷裕
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-18780081
[Presentation] ミクロダリアでのATPによる成熟型インターロイキシー1β産生に対するリゾリン脂質の効果2009
- Author(s)
  竹之内敬人, 木谷裕
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-18780081
[Presentation] リゾリン脂質とATPはミクログリアにおける成熟型インターロイキシー1βの産生を互いに抑制する2008
- Author(s)
  竹之内敬人, 岩丸祥史, 洲鎌秀永, 佐藤充, 橋本款, 木谷裕
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Year and Date
  2008-12-08
- Data Source
  KAKENHI-PROJECT-18780081
[Presentation] リゾリン脂質とATPはミクログリアにおける成熟型インターロイキシ-1βの産生を互いに抑制する2008
- Author(s)
  竹之内敬人, 岩丸祥史, 洲鎌秀永, 佐藤充, 橋本款, 木谷裕
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Year and Date
  2008-12-08
- Data Source
  KAKENHI-PROJECT-18780081
[Presentation] リゾホスファチジルコリンによるミクログリアP2X7受容体の機能調節2008
- Author(s)
  竹之内敬人、佐藤充、木谷裕
- Organizer
  日本農芸化学会2008年度大会
- Place of Presentation
  名古屋
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18780081
[Presentation] リゾボスファチジルコリンによるミクログリアP2X7受容体の機能調節2008
- Author(s)
  竹之内敬人、佐藤充、木谷裕
- Organizer
  日本農芸化学会2008年度大会
- Place of Presentation
  名古屋
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18780081
[Presentation] Potentiation of nucleotides-induced P2X7 receptor activation by lysophosphatidylcholine in mouse microglial cells2007
- Author(s)
  Takenouchi T, Sugama S, Sato M, Kitani H
- Organizer
  Society for Neuroscience 2007
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-18780081
[Presentation] Potentiation of nucleotides-induced P2X7 receptor activation by lysophosphatidylcholine in mouse microglial cells.2007
- Author(s)
  Takenouchi T, Sugama S, Sato M, Kitani H
- Organizer
  Society for Neuroscience
- Place of Presentation
  サンディエゴ(米国)
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-18780081

1. IWAMARU Yoshifumi (20355142)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. SUGAMA Shuei (70302461)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. HASHIMOTO Makoto (50189502)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. TSUKIMOTO Mitsutoshi (70434040)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
5. Shinkai Hiroki (30502687)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. UENISHI Hirohide (80391556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KITANI Hiroshi (30355739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. TAKAHAGI Yoichi (80520379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. KAKINUMA Yoshihiko (40233944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 北澤春樹 (10204885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 西山啓太 (40756029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大坪和香子 (00598203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 野地智法 (10708001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 須田義人 (90404847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Binghui Zhou (70906031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 原口清輝 (10324576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 舛甚賢太郎 (70425578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 平松香菜恵 (20969513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 池田里奈 (50991395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SUZUKI Junichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. MATSUMOTO Toshimi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. TOKI Daisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. Conti Bruno

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Takenouchi Takato 竹之内 敬人

TAKENOUCHI Takato 竹之内 敬人

Research Projects

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Co-Researchers

Development of in vitro models for analysis of livestock pathogens using a red river hog macrophage cell linePrincipal Investigator

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家畜健全育成向上戦略：イムノバイオティクスと自然免疫受容体の腸-肺軸シンフォニー

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The role of neuromodulatory factors in innate immune systemPrincipal Investigator

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Investigation of microglia and chronic stress in the onset of Parkinson disease

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Elucidation of genetic change associated with selection of immune competence in swine

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Secretome analysis for the search for novel danger signal alarmins in ATP-stimulated macrophagesPrincipal Investigator

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Investigation of microglial activation through noradrenaline in the process of neurodegenerative disease

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Study on the molecular mechanisms of prion secretion from microglial cellsPrincipal Investigator

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Establishment and characterization of immortalized cell lines derived from bovine brain tissuesPrincipal Investigator

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[Book] EMERGING DRUGS AND TARGETS FOR PARKINSON´S DISEASE2014

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[Book] Role of autophagy in P2X7 receptor-mediated maturation and unconventional secretion of IL-1β in microglia. AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection2013

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[Book] AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection (CHAPTER: ROLE OF AUTOPHAGY IN P2X7 RECEPTOR-MEDIATED MATURATION AND UNCONVENTIONAL SECRETION OF IL-1β IN MICROGLIA)2013

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[Journal Article] Evolvability of amyloidogenic proteins in human brain2018

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[Journal Article] Potential application of centrifuges to protect the CNS in space and on earth2018

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Takenouchi Takato 竹之内敬人

TAKENOUCHI Takato 竹之内敬人