Matsumura Tomohiro 松村智裕

… Alternative Names

MATSUMURA Tomohiro 松村智裕

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Researcher Number	20297930
Other IDs
Affiliation (Current)	2025: 日本医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2017: 日本医科大学, 医学部, 助教 2007 – 2010: Nippon Medical School, 医学部, Assist.Professor 1998 – 2006: 日本医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Functional biochemistry Except Principal Investigator Functional biochemistry / Otorhinolaryngology / Chemistry related to living body / Pathological medical chemistry / General medical chemistry / Structural biochemistry / Pathological medical chemistry / Biological Sciences
Keywords	Principal Investigator 結晶化 / X線結晶構造解析 / キサンチン尿症 / システインリアーゼ / キサンチン酸化還元酵素 / モリブドプテリンコファクター / モリブデン酵素 Except Principal Investigator キサンチン脱水素酵素 / 活性酸素 / peroxiredoxin … More / キサンチン酸化酵素 / HBP23 / 非ヘム鉄 / X線結晶解析 / ペルオキシレドキシン / 鉄結合タンパク質 / 金属タンパク質 / ALS / rat / ラット / non-heme iron / xanthine dehydrogenase / Xanthine Dehydrogenase / Xanthine Oxidase / EPR / フリーラジカル / 金属フラビン酵素 / NO合成酵素 / モリブデン酵素 / フラビン酵素 / スーパーオキシド / mRNA / Cochlin / cochlin / COCH / miRNA / inner ear / x-ray crystallography / Molecular dynamics / Xanthine oxidase / Anti-gout drug / Three-dimensional-structure based drug design / キサンチン脱水素酸素 / モリブデン配位子 / X-線結晶構造 / モリブデン水酸化機構 / モリブデン金属 / 蛋白質の基準振動計算 / X線結晶構造解析 / 蛋白質の基準振動検査 / キサンチンオキシダーゼ / 抗痛風薬 / 蛋白質の立体構造に基づく創薬 / c-Abl / c-Abl tyrosine kinase / チオレドキシン / c-Abe tyrosine kinase / Iron-binding protein / Peroxiredoxin / Non-heme iron / X-ray crystallography / Metallo protein / Active Oxygen / Peroxidase / peroxidase / superoxide anion / active oxygen / molybdenum enzyme / flavoprotein / xnathine oxidase / X-ray crystal structure / 部位特異的変異法 / X-線結晶解析 / heme binding protein / metallo-protein / niric oxide synthase / xanthine oxidase / reactive oxygen species / super oxide anion / nitric oxide / free radical / metalloprotein / Flavoprotein / nNOS / X線結晶構造 / 電子スピン共鳴 / セロビオース脱水素酵素 / モリブデン酸素 / 酸化酵素型-脱水素酵素型変換 / ノックインマウス / キサンチチン脱水素酵素 / キサンチチン酸化酵素 / トランスジェニックマウス / キサンチン酸化還元酵素 / 分子病態学 / ペルオキレドキシン Less

Development of a novel treatment for inner ear deafness -inhibition of the expression of Cochlin with RNAi-
- Principal Investigator
  
  Sekine Kuwon
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Nippon Medical School
Phasogenesis study of XOR mutant knock-in mouse.
- Principal Investigator
  
  OKAMOTO Ken, NISHINO Tomoko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nippon Medical School
モリブデン酵素の活性化を調節する新規タンパク質の反応機構Principal Investigator
- Principal Investigator
  
  松村智裕
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Nippon Medical School
Determination of fine structure of the molybdo-enzyme and mechanism of hydroxylation and protein vibration.
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Nippon Medical School
The role of HBP23 to chronic myelogenous keukemia
- Principal Investigator
  
  ABE Yasuko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nippon Medical School
Structure and function complex flavo-proteins which produce free radicals
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  NIPPON MEDICAL SCHOOL
活性酸素種による遺伝子発現誘導の分子基盤
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nippon Medical School
Analysis of cellular function of HBP23 on redox regulation
- Principal Investigator
  
  ABE Yasuko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Nippon Medical School
The structure and function of a complex metalloflavoprotein
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nippon Medical School
Structures and functions of metalloflavoenzymes which produce free radicals
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Functional biochemistry
- Research Institution
  NIPPON MEDICAL SCHOOL

All 2017 2011 2010 2009 2008 2007 2003 Other

All Journal Article Presentation

[Journal Article] Expression profiling of microRNAs in the inner ear of elderly people by real-time PCR quantification2017
- Author(s)
  Kuwon Sekine, Tomohiro Matsumura, Toshihiro Takizawa, Yurika Kimura, Shiho Saito, Kyoko Shiiba , Susumu Shindo, Kimihiro Okubo, Tesuo Ikezono
- Journal Title
  
  Audiol Neurootol
  
  Volume: 22 Issue: 3 Pages: 135-145
- DOI
  10.1159/000479724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11256, KAKENHI-PROJECT-26861423
[Journal Article] Dimer-Oligomer Interconversion of Wild-type and Mutant Rat 2-Cys Peroxiredoxin2008
- Author(s)
  Tomohiro Matsumura
- Journal Title
  
  J. B. C. 283(1)
  
  Pages: 284-293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16205021
[Journal Article] Dimer-Oligomer Interconversion of Wild-type and Mutant Rat2-Cys Peroxiredoxin2008
- Author(s)
  Tomohiro Matsumura
- Journal Title
  
  J.Biol.Chem. 283(1)
  
  Pages: 284-893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Journal Article] Dimer-Oligomer Interconversion of Wild-type and Mutant Rat 2-Cys Peroxiredoxi-n2008
- Author(s)
  Tormohiro Matsumura
- Journal Title
  
  J.Biol.Chem. 283・1
  
  Pages: 284-293
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16205021
[Journal Article] Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase.2003
- Author(s)
  Kuwabara, Y., Nishino, T., Okamoto, K., Matsumura, T., Eger, B., Pal, E., Nishino, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 100
  
  Pages: 8170-8175
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570132
[Journal Article] Redox sysetm expression in the motor neurone in amyrotropic lateral sclerosis (ASL):Immunohistochemical studies on sporadic ALS, superoxide dismutase 1 (SOD-1)mutated familial ALS, and SOD-1mutated ALS animal models.
- Author(s)
  Kato, S., Kato, M., Abe, Y., Matsumura, T., Nishino, T., Aoki, M., Itoyame, Y., Asayame, K., Awaya, A., Hirano, A., Ohama, E.
- Journal Title
  
  Acta Neuropathol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570132
[Presentation] Reaction mechanism and substrate binding mode of xanthine oxidoreductase.2011
- Author(s)
  Ken Okamoto、Yuko Kawaguchi、Teruo Kusano、Tomohiro Matsumura1、Koji Matsumoto、Takeshi Nishino
- Organizer
  14th International Symposium on Purine and Pyrimidine Metabolism in Man
- Place of Presentation
  東京
- Year and Date
  2011-02-20
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 14th International Symposium on Purine and Pyrimidine Metabolism in Man Reaction mechanism and substrate binding mode of xanthine oxidoreductase.2011
- Author(s)
  Ken Okamoto、Yuko Kawaguchi、Teruo Kusano、Tomohiro Matsumura 1、Koji Matsumoto、Takeshi Nishino
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ウシキサンチン酸化還元酵素と天然基質キサンチンとの反応中間体結晶構造Structure of xanthine oxidoreductase in action ; Reaction intermediate structure of milk xanthine oxidoreductase and natural substrate xanthine.2010
- Author(s)
  Ken Okamoto, Tomohiro Matsumura, Kusano Teruo, Koji Matsumoto, Takeshi Nishino
- Organizer
  2010年日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 新規キサンチン酸化還元酵素剤FYX-051の酵素学的,構造生物学的解析2009
- Author(s)
  松本浩二, 岡本研, 松村智裕, 草野輝男, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン酸化還元酵素の基質結合様式と基質活性化機構2009
- Author(s)
  岡本研, 松村智裕, 草野輝男, 松本浩二, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ラットキサンチン脱水素酵素におけるCH...O結合がFADの酸化還元電位に与える影響について2009
- Author(s)
  川口裕子, 西野朋子, 松村智裕, 岡本研, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ブチロフィリンが有す多機能B30.2/SPRYドメインとミルクキサンチン脱水素酵素との結合様式について2009
- Author(s)
  西野朋子, 李穎, 岡本研, 草野輝男, 川口裕子, 松村智裕, 他
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ラットキサンチン脱水素酵素における機能的CH...O水素結合の存在2009
- Author(s)
  川口裕子, 西野朋子, 松村智裕, 岡本研, 西野武士
- Organizer
  第9回蛋白質科学会年会
- Place of Presentation
  熊本
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] Crystal Structure of Human Xanthine Oxidoreductase2007
- Author(s)
  Tomohiro Matsumura
- Organizer
  Gordon Research Conferences(Molybdenum & Tungsten Enzymes)
- Place of Presentation
  U.S.A
- Year and Date
  2007-07-01
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] Mutational Analysis of Human Xanthine Oxidase: Roles of the Amino Acid Residues around the Active Site in Purine Oxidation Reaction2007
- Author(s)
  Tomohiro Matsumura
- Organizer
  12th International Symposium on Purine and Pyrimidine Metabolism in Man
- Place of Presentation
  アメリカシカゴ
- Year and Date
  2007-06-24
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] Mutatioanl Analysis of Human Xanthine Oxidase : Roles of the Amino Acid Residues around the Active Site in Purine Oxidation Reaction2007
- Author(s)
  Tomohiro Matsumura
- Organizer
  12th International Symposiumj on Purine and Pyrimidine Metabolism in Man
- Place of Presentation
  アメリカ
- Year and Date
  2007-06-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] Crystal Structure of Human Xanthine Oxidoreductase2007
- Author(s)
  Tomohiro Matsumura
- Organizer
  Goodon Research Conferences(Molybdenum & Tungstem Enzymes)
- Place of Presentation
  アメリカ
- Year and Date
  2007-07-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] Mutational Analysis of Human Xanthine Oxidase : Roles of the Amino Acid Residues around the Active Site in Purine Oxidation Reaction2007
- Author(s)
  Tomohiro Matsumura
- Organizer
  12th International Symposium on Purine and Pyrimidine Metabolism in Man
- Place of Presentation
  U.S.A
- Year and Date
  2007-06-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] ヒトキサンチン酸化還元酵素の構造解析2007
- Author(s)
  松村智裕
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] Crystal Structure of Human Xanthine Oxidoreductase2007
- Author(s)
  Tomohiro Matsumura
- Organizer
  Gordon Research Conferences(Molybdenum & Tungsten Enzymes)
- Place of Presentation
  アメリカニューロンドン
- Year and Date
  2007-07-01
- Data Source
  KAKENHI-PROJECT-16205021

1. NISHINO Takeshi (40094312)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
2. OKAMOTO Ken (60267143)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
3. ABE Yasuko (60089612)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
4. NISHINO Tomoko (80075613)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
5. IWASAKI Toshio (40277497)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KUSANO Teruo (30434129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. KIKUCHI Hiroto (00224907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Sekine Kuwon (20566377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IKEZONO Tetsuo (80277491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 片山映 (10333113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 堀弘幸 (20256960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 永原則之 (10208043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. PAI Emil F.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 瀧澤俊広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Matsumura Tomohiro 松村 智裕

MATSUMURA Tomohiro 松村 智裕

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モリブデン酵素の活性化を調節する新規タンパク質の反応機構Principal Investigator

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[Journal Article] Expression profiling of microRNAs in the inner ear of elderly people by real-time PCR quantification2017

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[Journal Article] Dimer-Oligomer Interconversion of Wild-type and Mutant Rat 2-Cys Peroxiredoxin2008

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[Journal Article] Dimer-Oligomer Interconversion of Wild-type and Mutant Rat2-Cys Peroxiredoxin2008

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[Journal Article] Dimer-Oligomer Interconversion of Wild-type and Mutant Rat 2-Cys Peroxiredoxi-n2008

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[Journal Article] Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase.2003

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Matsumura Tomohiro 松村智裕

MATSUMURA Tomohiro 松村智裕