TAKAHASHI Toshifumi 高橋俊文

Researcher Number	20302292
Other IDs	https://orcid.org/0000-0003-0955-4248
Affiliation (Current)	2022: 福島県立医科大学, 公私立大学の部局等, 教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 福島県立医科大学, 公私立大学の部局等, 教授 2007 – 2015: Yamagata University, School of Medicine, Associate professor 2010: 山形大学, 医学部, 講獅 2006: 山形大学, 医学部, 助手 1998 – 2003: 山形大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology / Basic Section 58010:Medical management and medical sociology-related Except Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology / Basic Section 58010:Medical management and medical sociology-related / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 58070:Lifelong developmental nursing-related
Keywords	Principal Investigator 卵の加齢 / ミトコンドリア / 加齢マウス / 不妊症 / GFP / FRET / EGF / IGF-1 / 未受精卵 / 凍結保存 … More Except Principal Investigator ハニカム膜 / 卵巣癌 / 薬剤耐性 / エストロゲン / エストロゲン受容体 / 血管平滑筋細胞 / 誘導型NO合成酵素 / 転写因子 / 生殖医学 / 小胞体ストレス / 若返り / 細胞増殖 / 細胞接着 / 卵巣癌幹細胞 / 癌幹細胞 / 卵胞 / CD44 / 体外受精 / 顕微授精 / 不妊症 / マウス卵 / 加齢 / thapsigargin / tunicamycin / BiP / 血管平滑筋 / 卵巣がん / 薬剤耐性化 / Rho/ROCK経路 / EGF受容体 / Trabectedin / mTOR / メタボローム解析 / 卵巣明細胞腺癌 / microRNA / オートファジー / メタボロミクス / 薬剤耐性化機構 / トラベクテジン / AKT-mTORシグナル / ポリコーム複合体 / 薬剤感受性 / エピジェネティク / マウス / 加齢卵 / salubrinal / salburinal / ミトコンドリア / 小胞体 / Salubrinal / 生体親和性多孔性膜 / 顆粒膜細胞 / steroid産生 / アポトージス / 卵透明帯 / Ovarian follicle / Granulosa Cell / Steroidogenesis / Apoptosis / 卵の質 / 細胞周期 / 酸化ストレス / 8-OHdG / グルタチオンリダクターゼ / 卵 / 胚 / テロメラーゼ / アポトーシス / 凍結 / ヒアルロン酸 / quality of oocyte / oxidative stress / cell cycle / 8 OhdG / glutathione reductase / 子宮平滑筋 / イオンチャネル / 分子生理学 / Myometrium / Ion channel / Molecular physiology / 卵細胞質内精子注入法 / 子宮内膜症 / 心血管系疾患 / 炎症 / ナースヘルス研究 / ヘルスケア / ホルモン療法 / 先制医療 / 生殖補助医療 / 臨床決断 / 判断樹 / ビッグデータ / プレコンセプションケア / 不育症 / 栄養 / 災害医療 / 産科医療教育 / シミュレーション / 妊産婦 / 産科医療 Less

The elucidation of the molecular mechanism of fertility improvement by improving the nutritional environment as preconception care
- Principal Investigator
  
  太田邦明
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Toho University
災害時の産科医療教育プログラムと妊産婦行動支援のための情報ツールの開発
- Principal Investigator
  
  神保正利
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58070:Lifelong developmental nursing-related
- Research Institution
  Fukushima Medical University
Quantitative analysis of regional disparities in medical care in obstetrics and gynecology-analysis using medical big data and GPrincipal Investigator
- Principal Investigator
  
  高橋俊文
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Fukushima Medical University
Development of treatment algorithm in infertility couples based on big data analysis
- Principal Investigator
  
  鈴木大輔
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Fukushima Medical University
卵細胞質内精子注入法に特化した精子選択法・精子評価法の確立と治療前診断への応用
- Principal Investigator
  
  菅沼亮太
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Fukushima Medical University
Possibility of preemptive medicine for cardiovascular disease in women with endometriosis: a clinical epidemiology approach
- Principal Investigator
  
  Mizunuma Hideki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Fukushima Medical University
Development of a new treatment for the deterioration of egg quality by aging based on mitochondrial quality controlPrincipal Investigator
- Principal Investigator
  
  Takahashi Toshifumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Fukushima Medical University
Therapeutic strategy for reproductive aged women by regulation of oxidative stress and endoprasmic reticulum stress
- Principal Investigator
  
  IGARASHI Hideki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
The possibility of 3D porous scaffold honeycomb films for the new strategy of treatment with ovarian cancer
- Principal Investigator
  
  OHTA Tsuyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Development of treatment strategy for age-related decline in oocyte quality by analyzing lipid metabolismPrincipal Investigator
- Principal Investigator
  
  Takahashi Toshifumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
The role of epigenetic effector polycomb group gene in ovarian cancers
- Principal Investigator
  
  SUDO Takeshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
The identification of drug resistance in ovarian cancer : new insights form metabolomics and autophagy
- Principal Investigator
  
  KURACHI HIROHISA
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Molecular mechanism of aging-related decline in oocyte quality: a study of metabolomics and autophagyPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Toshifumi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Analysis of regulation of the inducible nitric oxide synthase geneby estrogen receptor alpha and beta
- Principal Investigator
  
  TSUTSUMI Seiji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Study of rejuvenation of aged oocyte "Aim at the establishment of the strategy of a new fertility treatment"
- Principal Investigator
  
  IGARASHI Hideki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Differential regulation of the inducible nitric oxide synthase gene by estrogen receptors αand β
- Principal Investigator
  
  TSUTSUMI Seiji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Study ofion channels involved in uterine smooth muscle cells contraction by using molecular physiological approachPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Toshifumi, 手塚尚広
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Crosstalk between estrogen receptor and transcriptional factors in the presence of SERMPrincipal Investigator
- Principal Investigator
  
  KOJIMAHARA Takanobu, 高橋俊文
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
DYNAMICS OF ION CHANNEL EXPRESSION IN PREGNANT RAT MYOMETRIUM : ANALYSIS MOLECULAR PHYSIOLOGICAL
- Principal Investigator
  
  TEZUKA Naohiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
ガラス化法による女性配偶子の凍結保存に関する研究Principal Investigator
- Principal Investigator
  
  高橋俊文
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Study of factors regulating the development of follicles, oocytes and embryos
- Principal Investigator
  
  SAITO Hidekazu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Studies on the regulatory mechanism of interaction between the development of ovulatry follicle and ovum in the ovary.
- Principal Investigator
  
  HIROI Masahiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  YAMAGATA UNIVERSITY

All 2020 2019 2017 2016 2015 2013 2012 2011 2010 2008 2007 2005 Other

All Journal Article Presentation

[Journal Article] The number of overall hysterectomies per population with the perimenopausal status is increasing in Japan: A national representative cohort study2020
- Author(s)
  Isobe Masanori、Kataoka Yuki、Chikazawa Kenro、Nishigori Hiroshi、Takahashi Toshifumi、Enomoto Takayuki
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 46 Pages: 2651-2661
- DOI
  10.1111/jog.14517
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10486
[Journal Article] Correlation between the number of laparoscopy‐qualified gynecologists and the proportion of laparoscopic surgeries for benign gynecological diseases in Japan: An ecological study2020
- Author(s)
  Isobe Masanori、Kataoka Yuki、Chikazawa Kenro、Hada Tomonori、Nishigori Hiroshi、Takahashi Toshifumi、Enomoto Takayuki
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 47 Pages: 329-336
- DOI
  10.1111/jog.14528
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10486
[Journal Article] Poor embryo development in post-ovulatoryin vivo-aged mouse oocytes is associated with mitochondrial dysfunction, but mitochondrial transfer from somatic cells is not sufficient for rejuvenation2016
- Author(s)
  Igarashi H, Takahashi T, Abe H, Nakano H, Nakajima O, Nagase S
- Journal Title
  
  Human Reproduction
  
  Volume: 31 Pages: 23331-23338
- DOI
  10.1093/humrep/dew203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462474, KAKENHI-PROJECT-16K11080, KAKENHI-PROJECT-16H03189
[Journal Article] Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies2015
- Author(s)
  Igarashi, Hideki Takahashi, Toshifumi Nagase, Satoru
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 14 Pages: 159-169
- DOI
  10.1007/s12522-015-0209-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462474
[Journal Article] miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression.2013
- Author(s)
  Ohyagi-Hara C, Sawada K, Mabuchi S, Takahashi T, Kurachi H.（他12名、15番目）
- Journal Title
  
  Am J Pathol
  
  Volume: 182 Pages: 1876-1889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308
[Journal Article] Non-sex Cord-stromal ovarian tumors frequently produce and secrete estrogen in postmenopausal women: impact on bone metabolism and abnormal endometrial histology.2013
- Author(s)
  Matsumura S, Ohta T, Takahashi T, T Kurachi H
- Journal Title
  
  J Clin Endocrinol Metab.
  
  Volume: 98(7) Pages: 2775-2782
- DOI
  10.1210/jc.2013-1267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-24659723, KAKENHI-PROJECT-24791680, KAKENHI-PROJECT-25340047
[Journal Article] Non-sex cord-stromal ovarian tumors frequently produce and secrete estrogen in postmenopausal women:impact on bone metabolism and abnormal endometrial histology.2013
- Author(s)
  Matsumura S, Ohta T, Takahashi T, T Kurachi H. （他2名、6番目）
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: 98 Pages: 2775-2782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308
[Journal Article] MiR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression.2013
- Author(s)
  Ohyagi-Hara C, Sawada K, Kamiura S, Tomita Y, Isobe A, Hashimoto K, Kinose Y, Mabuchi S, Hisamatsu T, Takahashi T, Kumasawa K, Nagata S, Morishige K-I, Lengyel E, Kurachi H, Kimura T.
- Journal Title
  
  Am J Pathol
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-22390308
[Journal Article] Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells.2013
- Author(s)
  Ohta T, Takahashi T, Kurachi H
- Journal Title
  
  Cancer Biol Ther
  
  Volume: 13(7) Pages: 25-33
- DOI
  10.4161/cbt.13.1.18440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-24659723, KAKENHI-PROJECT-24791680
[Journal Article] Estradiol and raloxifene induce the proliferation of osteoblasts through G-protein-coupled receptor GPR30.2013
- Author(s)
  Ohyagi-Hara C, Sawada K, Mabuchi S, Takahashi T, Kurachi H
- Journal Title
  
  Am J Pathol.
  
  Volume: 182(5) Pages: 1876-1889
- DOI
  10.1016/j.ajpath.2013.01.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-23592443, KAKENHI-PROJECT-23592447, KAKENHI-PROJECT-23890102, KAKENHI-PROJECT-24249080, KAKENHI-PROJECT-24590459, KAKENHI-PROJECT-24659723, KAKENHI-PROJECT-25293342, KAKENHI-PROJECT-25462588
[Journal Article] [妊孕能を考える]卵の加齢2012
- Author(s)
  高橋俊文、高橋可菜子、倉智博久
- Journal Title
  
  産婦人科の実際
  
  Volume: 61 Pages: 1885-1890
- Data Source
  KAKENHI-PROJECT-22591815
[Journal Article] Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells.2012
- Author(s)
  Ohta T, Takahashi T, Kurachi H
- Journal Title
  
  Cancer Biol Ther
  
  Volume: 13(6) Pages: 408-16
- DOI
  10.4161/cbt.19292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-24659723, KAKENHI-PROJECT-24791680
[Journal Article] 酸化ストレスと卵の加齢2012
- Author(s)
  高橋俊文、石田博美、倉智博久
- Journal Title
  
  HORMONE FRONTIER INGYNECOLOGY
  
  Volume: 19 Pages: 149-155
- Data Source
  KAKENHI-PROJECT-22591815
[Journal Article] 婦人科腫瘍との鑑別が困難であったGISTの2例.2012
- Author(s)
  松村創平,太田剛,水谷雅臣,蜂谷修,木村理,菅井幸雄,高橋一広,倉智博久.
- Journal Title
  
  臨床婦人科産科
  
  Volume: 66（9） Pages: 799-802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308
[Journal Article] Estrogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells2011
- Author(s)
  高橋一広、堤誠司、倉智博久, 他
- Journal Title
  
  Mol Cell Neurosci
  
  Volume: 48 Pages: 217-224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592121
[Journal Article] The activity of trabectedin as a single agent or in combination with everolimus for clear cell carcinoma of the ovary2011
- Author(s)
  Mabuchi S, Sawada K, Takahashi T, Kurachi H
- Journal Title
  
  Clin Cancer Res
  
  Volume: 17(13) Pages: 4462-4473
- DOI
  10.1158/1078-0432.ccr-10-2987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-23890101, KAKENHI-PROJECT-24659723
[Journal Article] Cellular and molecular mechanisms of various types of oocyteaging2011
- Author(s)
  Takahashi T, Igarashi H, Amita M, Hara S, Kurachi H.
- Journal Title
  
  Reprod Med Biol
  
  Volume: 10 Pages: 239-249
- DOI
  10.1007/s12522-011-0099-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591815
[Journal Article] 母体の加齢による卵の加齢のメカニズム2011
- Author(s)
  高橋俊文、前川絢子、倉智博久
- Journal Title
  
  産科と婦人科
  
  Volume: 78 Pages: 929-934
- Data Source
  KAKENHI-PROJECT-22591815
[Journal Article] Estrogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells2011
- Author(s)
  Takahashi K, Piao S, Yamatani H, Du B, Yin L, Ohta T, Kawagoe J, Takata K, Tsutsumi S, Kurachi H
- Journal Title
  
  Mol Cell Neurosci
  
  Volume: 48 Pages: 217-224
- DOI
  10.1016/j.mcn.2011.08.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308
[Journal Article] Estrogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells2011
- Author(s)
  Takahashi K, Piao S, Yamatani H, Du B, Yin L, Ohta T, Kawagoe J, Takata K, Tsutsumi S, Kurachi H.
- Journal Title
  
  Mol Cell Neurosci
  
  Volume: 48 Pages: 217-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592121
[Journal Article] Effect of dienogest on estrogen-induced nitric oxide production in human umbilical vein endothelial cell and endothelium-dependent vasodilatation in postmenopausal women.2010
- Author(s)
  堤誠司、高橋俊文、倉智博久, 他
- Journal Title
  
  Menopause
  
  Volume: 17 Pages: 615-621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592121
[Journal Article] Roles of prostagrandins during oocytes maturation : lessons from knockout mice.2010
- Author(s)
  Takahashi T, Igarashi H, Amita M, Hara S, Kurachi H
- Journal Title
  
  J Mamm Ova Res 27
  
  Pages: 11-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591905
[Journal Article] Effect of dienogest on estrogen-induced nitric oxide production in human umbilical vein endothelial cells and endothelium-dependent vasodilatation in postmenopausal women2010
- Author(s)
  Henmi N, Takahashi K, Amita M, Takata K, Ohta T, Tsutsumi S, Takahashi T, Kurachi H.
- Journal Title
  
  Menopause
  
  Volume: 17 Pages: 615-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592121
[Journal Article] Usefulness of Bezafibrate for Ovulation Induction in Clomiphene Citrate-Resistant Polycystic Ovary Syndrome Patients with Dyslipidemia : A Prospective Pilot study of Seven Cases.2010
- Author(s)
  Hara S, Takahashi T, Amita M, Igarashi H, Kurachi H
- Journal Title
  
  Gynecol Obstet Invest. 16
  
  Pages: 166-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591905
[Journal Article] Usefulness of Bezafibrate for Ovulation Induction in Clomiphene Citrate-Resistant Polycystic Ovary Syndrome Patients with Dyslipidemia : A Prospective Pilot Study of Seven Cases.2010
- Author(s)
  Shuichiro Hara, Toshifumi Takahashi, Mitsuyoshi Amita, Hideki Igarashi, Hirohisa Kurachi
- Journal Title
  
  Gynecol Obstet Invest.
  
  Volume: 70 Pages: 166-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591905
[Journal Article] Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate2010
- Author(s)
  Amita M, Takahashi T, Tsutsumi S, Ohta T, Takata K, Henmi N, Hara S, Igarashi H, Takahashi K, Kurachi H.
- Journal Title
  
  Endocrinology
  
  Volume: 151 Pages: 394-405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592121
[Journal Article] Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate.2010
- Author(s)
  堤誠司、高橋俊文、倉智博久, 他
- Journal Title
  
  Endocrinology
  
  Volume: 151 Pages: 394-405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592121
[Journal Article] Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate2010
- Author(s)
  Amita M, Takahashi T, Ohta T, Takata K, Kurachi H
- Journal Title
  
  Endocrinology
  
  Volume: 151(1) Pages: 394-405
- DOI
  10.1210/en.2009-0721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-24659723
[Journal Article] Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate.2010
- Author(s)
  Amita M, Takahashi T, Tsutsumi S, Ohta T, Takata K, Henmi N, Hara S, Igarashi K, Takahashi K, Kurachi H.
- Journal Title
  
  Endocrinology
  
  Volume: 151 Pages: 394-405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308
[Journal Article] Differential regulation of the induciblenitric oxide synthase gene by estrogen receptors 1 and 22008
- Author(s)
  Tsutsumi S, Zhang X, Takata K, Takahashi K, Karas RH, Kurachi H. Mendelsohn ME.
- Journal Title
  
  J Endocrinol 199(2)
  
  Pages: 267-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591922
[Journal Article] Mechanism of the divergent effects of estrogen on the cell proliferation of human umbilical endothelial versus aortismooth muscle cells2007
- Author(s)
  Kawagoe J, Ohmichi M, Tsutsumi S, OhtaT, Takahashi K, Kurachi H.
- Journal Title
  
  Endocrinology 148(12)
  
  Pages: 6092-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591922
[Journal Article] Raloxifene improves the ovariectomy-induced impairment in endothelium-dependent vasodilation2007
- Author(s)
  Takahashi, K.
- Journal Title
  
  Menopause 14
  
  Pages: 656-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591922
[Journal Article] Growth Factors Change Nuclear Distribution of Estrogen receptor-a via Mitogen-activated Protein Kinase or Phosphatidylinositol 3-kinase Cascade in a Human Breast Cancer Cell Line2005
- Author(s)
  Takahashi T et al.
- Journal Title
  
  Endocrinology 146
  
  Pages: 4082-44089
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591726
[Journal Article] Molecular mechanism of poor embryo development in postovulatory aged oocytes
- Author(s)
  Takahashi T, Igarashi H, Amita M, Hara S, Koki M, Kurachi H.
- Journal Title
  
  Mini review
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591815
[Presentation] Prevalence and predictive factors for complete fertilization failure in in vitro fertilization treatment cycles: a retrospective analysis of a large-scale nationwide database study2020
- Author(s)
  Takahashi T, Ota K, Mizunuma H.
- Organizer
  36th Annual Meeting ESHRE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09976
[Presentation] Predictive factors for dizygotic twin pregnancies after single embryo transfer: a retrospective analysis of a large-scale nationwide database study2020
- Author(s)
  Takahashi T, Ota K.
- Organizer
  ASRM 2020 Scientific Congress & Expo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09976
[Presentation] Predictive factors for dizygotic twin pregnancies after single embryo transfer: a retrospective analysis of a large-scale nationwide database study2019
- Author(s)
  Takahashi T, Takehara I, Ota K, Mizunuma H, Nagase S
- Organizer
  35th Annual Meeting ESHRE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09976
[Presentation] Predictive factors for oocyte retrieval failure in treatment cycles with assisted reproductive technology: a retrospective cohort study using the nation-wide ART registry of Japan.2019
- Author(s)
  Takahashi T, Ota K
- Organizer
  ASRM 2019 Scientific Congress & Expo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09976
[Presentation] Mitochondrial transfer from somatic cells is not sufficient for rejuvenation of postovulatory in vivo-aged mouse oocytes2017
- Author(s)
  Igarashi H, Takahashi T, Abe H, Nakano H, Nakajima O, Nagase S, Kyono K
- Organizer
  The 7th Congress of Asia Pacific Initiative on Reproduction
- Place of Presentation
  Kuala Lumpur, Malaysia, Kuala Lumpur Convention Centre
- Year and Date
  2017-03-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462474
[Presentation] MITOCHONDRIAL TRANSFER FROM SOMATIC CELLS IS NOT SUFFICIENT FOR REJUVENATION OF POSTOVULATORY IN VIVOAGED MOUSE OOCYTES2017
- Author(s)
  Igarashi H, Takahashi T, Abe H, Nakano H, Nakajima O, Nagase S, Kyono K
- Organizer
  The 7th Congress of the Asia Pacific Initiative on Reproduction
- Place of Presentation
  Kuala Lumpur Convention Center, Kuala Lumpur, Malaysia
- Year and Date
  2017-03-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11080
[Presentation] 2年前の膀胱癌由来と思われる腹膜偽粘液腫の1例2013
- Author(s)
  小島原敬信, 高橋俊文, 松尾幸城, 松村創平, 小幡美由紀, 松川淳, 倉智博久
- Organizer
  第65回日本産科婦人科学会
- Place of Presentation
  札幌市教育文化会館(札幌市)
- Data Source
  KAKENHI-PROJECT-22390308
[Presentation] 2年前の膀胱癌由来と思われる腹膜偽粘液腫の1例.2013
- Author(s)
  小島原敬信, 高橋俊文, 松尾幸城, 松村創平, 小幡美由紀, 松川淳, 倉智博久.
- Organizer
  第65回日本産科婦人科学会
- Place of Presentation
  札幌市教育文化会館（札幌市）
- Data Source
  KAKENHI-PROJECT-22390308
[Presentation] 卵の加齢の分子機構2012
- Author(s)
  高橋俊文
- Organizer
  第64回日本産科婦人科学会
- Place of Presentation
  神戸ポートピアホテルおよび神戸国際展示場(神戸市)
- Year and Date
  2012-04-13
- Data Source
  KAKENHI-PROJECT-22591815
[Presentation] 術後に卵巣小細胞癌と子宮体癌の重複癌と判明した一例.2012
- Author(s)
  松村創平,高橋俊文,倉智博久.
- Organizer
  第133回東北連合産科婦人科学会
- Place of Presentation
  秋田
- Data Source
  KAKENHI-PROJECT-22390308
[Presentation] 術後多発肺転移をきたした類上皮栄養膜細胞腫瘍の一症例2011
- Author(s)
  須藤毅, 小島原敬信, 成味恵, 清野学, 高橋一広, 中原健次, 倉智博久, 本山悌一
- Organizer
  第50回日本産科腫瘍学会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22390308
[Presentation] 卵加齢メカニズムの新しい概念:マウス卵の加齢に小胞体ストレスが関与する2011
- Author(s)
  五十嵐秀樹、網田光善、原周一郎、堤誠司、高橋俊文、倉智博久
- Organizer
  第63回日本産科婦人科学会
- Place of Presentation
  リーガロイヤルホテル大阪および大阪国際会議場(大阪市)
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-22591815
[Presentation] 卵のagingと酸化ストレス2011
- Author(s)
  高橋俊文
- Organizer
  第29回日本受精着床学会
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-22591815
[Presentation] 卵の加齢メカニズムにおける小胞体ストレスの関与についての検討2011
- Author(s)
  五十嵐秀樹、高橋俊文、原周一郎、松尾幸城、倉智博久
- Organizer
  第56回日本生殖医学会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-22591815
[Presentation] GFP-ERαを用いた子宮内膜細胞におけるエストロゲン・抗エストロゲン作用の可視化2010
- Author(s)
  網田光善, 高橋俊文, 原周一郎, 五十嵐秀樹, 倉智博久
- Organizer
  第55回日本生殖医学会
- Place of Presentation
  徳島あわぎんホール
- Data Source
  KAKENHI-PROJECT-22390308
[Presentation] 化学療法後の卵巣癌再発巣におけるAktとERKの活性化は予後良好因子である2010
- Author(s)
  清野学, 太田剛, 高橋俊文, 逸見典子, 須藤毅, 本山悌一, 倉智博久
- Organizer
  第62回日本産科婦人科学会
- Place of Presentation
  東京国際フォーラム(東京都)
- Data Source
  KAKENHI-PROJECT-22390308
[Presentation] 加齢マウスにおける卵の老化による胚発育悪化のメカニズム2010
- Author(s)
  高橋俊文
- Organizer
  第28回日本受精着床学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-22591815
[Presentation] GFP結合ERαを用いた子宮内膜細胞におけるエストロゲン, 抗エストロゲン作用の可視化2010
- Author(s)
  網田光善, 高橋俊文, 原周一郎, 五十嵐秀樹, 倉智博久
- Organizer
  第62回日本産科婦人科学会
- Place of Presentation
  東京国際フォーラム(東京都)
- Data Source
  KAKENHI-PROJECT-22390308
[Presentation] マウス加齢卵における卵の質の改善を目的としたミトコンドリア移植の試み.2008
- Author(s)
  五十嵐秀樹、高橋俊文、網田光善、倉智博久
- Organizer
  第49回日本哺乳動物卵子学会
- Place of Presentation
  名古屋
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-20591905
[Presentation] マウス加齢卵におけるミトコンドリア機能の評価とミトコンドリア移植の試み2008
- Author(s)
  五十嵐秀樹、高橋俊文、網田光善、倉智博久
- Organizer
  第53回日本生殖医学会総会・学術講演会
- Place of Presentation
  神戸市
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-20591905
[Presentation] Impact of endoplasmic reticulum stress on the postovulatory aging of the mouse oocyte
- Author(s)
  H. Igarashi, T. Takahashi, M. Amita, A. Hasegawa
- Organizer
  ASRM 2014
- Place of Presentation
  Hawaii Convention Center (Honolulu, Hawaii)
- Year and Date
  2014-10-18 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-26462474
[Presentation] 卵の加齢の分子機構
- Author(s)
  高橋俊文
- Organizer
  第64回日本産科婦人科学会
- Place of Presentation
  神戸国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-22591815

1. KURACHI Hirohisa (40153366)

# of Collaborated Projects: 9 results

# of Collaborated Products: 34 results
2. IGARASHI Hideki (80333970)

# of Collaborated Projects: 8 results

# of Collaborated Products: 14 results
3. TSUTSUMI Seiji (50323168)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
4. OHTA Tsuyoshi (50375341)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
5. 太田邦明 (90424142)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SUTOH Takeshi (70466605)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. SAITO Takakazu (00272071)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SAITO Hidekazu (90125766)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. AMITA Mitsuyoshi (30420061)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
10. NAKAHARA Kenji (80250934)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. TEZUKA Naohiro (60261690)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. TAKAHASHI Kazuhiro (20292427)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
13. KOJIMAHARA Takanobu (20344806)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 菅沼亮太 (30528211)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. TAKATA Keiko (70375343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. MABUCHI Seiji (00452441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
17. SAWADA Kenjiro (00452392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
18. HARA Shuichiro (10436230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MATSUO Koki (90594317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HIROI Masahiko (60018364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ITOH Mariko (40292429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KAWACHIYA Satoshi (30322001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. Mizunuma Hideki (10125875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 太田信彦 (40301072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 鈴木大輔 (90401851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 神保正利 (80750413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. MIMURA Kazuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. ISOBE Aki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. ABE Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 山崎岳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 森重健一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 橋本香映

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 熊澤惠一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 木村正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 富田裕彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAHASHI Toshifumi 高橋 俊文

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Quantitative analysis of regional disparities in medical care in obstetrics and gynecology-analysis using medical big data and GPrincipal Investigator

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Development of a new treatment for the deterioration of egg quality by aging based on mitochondrial quality controlPrincipal Investigator

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Development of treatment strategy for age-related decline in oocyte quality by analyzing lipid metabolismPrincipal Investigator

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Molecular mechanism of aging-related decline in oocyte quality: a study of metabolomics and autophagyPrincipal Investigator

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TAKAHASHI Toshifumi 高橋俊文