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TAKAHASHI Toshifumi  高橋 俊文

Researcher Number 20302292
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-0955-4248
Affiliation (Current) 2022: 福島県立医科大学, 公私立大学の部局等, 教授
Affiliation (based on the past Project Information) *help 2016 – 2021: 福島県立医科大学, 公私立大学の部局等, 教授
2007 – 2015: Yamagata University, School of Medicine, Associate professor
2010: 山形大学, 医学部, 講獅
2006: 山形大学, 医学部, 助手
1998 – 2003: 山形大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Obstetrics and gynecology / Obstetrics and gynecology / Basic Section 58010:Medical management and medical sociology-related
Except Principal Investigator
Obstetrics and gynecology / Obstetrics and gynecology / Basic Section 58010:Medical management and medical sociology-related / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 58070:Lifelong developmental nursing-related
Keywords
Principal Investigator
卵の加齢 / ミトコンドリア / 加齢マウス / 不妊症 / GFP / FRET / EGF / IGF-1 / 未受精卵 / 凍結保存 … More / ガラス化法 / 細胞内カルシウム濃度 / 体外受精 / メタボロミクス / オートファジー / 細胞内カルシウム制御機構 / ATP / 細胞内カルシウム / カルシウムオシレーション / メタボローム / アポトーシス / 酸化ストレス / リピドミクス / ベータ酸化 / 脂肪酸 / カルニチン / ピルビン酸脱水素酵素 / エストロゲン / 選択的エストロゲン受容体モジュレーター(SERM) / 成長因子 / エストロゲン受容体 / SERM / estrogen / selective estrogen receptor modulator (SERM) / growth factor / イオンチャネル / 子宮平滑筋 / 妊娠 / カルシウムチャネル / Kチャネル / 分子生理学 / Ion channels / Smooth muscle cells / Pregnancy / Calcium channel / Potasium channel / マイトファジー / LC3 / Parkin / TFAM / 産婦人科 / 地域格差 / NDB / DPC / ビッグデータ / 腹腔鏡下手術 / 子宮摘出 / 医療ビッグデータ / GIS … More
Except Principal Investigator
ハニカム膜 / 卵巣癌 / 薬剤耐性 / エストロゲン / エストロゲン受容体 / 血管平滑筋細胞 / 誘導型NO合成酵素 / 転写因子 / 生殖医学 / 小胞体ストレス / 若返り / 細胞増殖 / 細胞接着 / 卵巣癌幹細胞 / 癌幹細胞 / 卵胞 / CD44 / 体外受精 / 顕微授精 / 不妊症 / マウス卵 / 加齢 / thapsigargin / tunicamycin / BiP / 血管平滑筋 / 卵巣がん / 薬剤耐性化 / Rho/ROCK経路 / EGF受容体 / Trabectedin / mTOR / メタボローム解析 / 卵巣明細胞腺癌 / microRNA / オートファジー / メタボロミクス / 薬剤耐性化機構 / トラベクテジン / AKT-mTORシグナル / ポリコーム複合体 / 薬剤感受性 / エピジェネティク / マウス / 加齢卵 / salubrinal / salburinal / ミトコンドリア / 小胞体 / Salubrinal / 生体親和性多孔性膜 / 顆粒膜細胞 / steroid産生 / アポトージス / 卵透明帯 / Ovarian follicle / Granulosa Cell / Steroidogenesis / Apoptosis / 卵の質 / 細胞周期 / 酸化ストレス / 8-OHdG / グルタチオンリダクターゼ / 卵 / 胚 / テロメラーゼ / アポトーシス / 凍結 / ヒアルロン酸 / quality of oocyte / oxidative stress / cell cycle / 8 OhdG / glutathione reductase / 子宮平滑筋 / イオンチャネル / 分子生理学 / Myometrium / Ion channel / Molecular physiology / 卵細胞質内精子注入法 / 子宮内膜症 / 心血管系疾患 / 炎症 / ナースヘルス研究 / ヘルスケア / ホルモン療法 / 先制医療 / 生殖補助医療 / 臨床決断 / 判断樹 / ビッグデータ / プレコンセプションケア / 不育症 / 栄養 / 災害医療 / 産科医療教育 / シミュレーション / 妊産婦 / 産科医療 Less
  • Research Projects

    (22 results)
  • Research Products

    (56 results)
  • Co-Researchers

    (35 People)
  •  The elucidation of the molecular mechanism of fertility improvement by improving the nutritional environment as preconception care

    • Principal Investigator
      太田 邦明
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Toho University
  •  災害時の産科医療教育プログラムと妊産婦行動支援のための情報ツールの開発

    • Principal Investigator
      神保 正利
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58070:Lifelong developmental nursing-related
    • Research Institution
      Fukushima Medical University
  •  Quantitative analysis of regional disparities in medical care in obstetrics and gynecology-analysis using medical big data and GPrincipal Investigator

    • Principal Investigator
      高橋 俊文
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58010:Medical management and medical sociology-related
    • Research Institution
      Fukushima Medical University
  •  Development of treatment algorithm in infertility couples based on big data analysis

    • Principal Investigator
      鈴木 大輔
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58010:Medical management and medical sociology-related
    • Research Institution
      Fukushima Medical University
  •  卵細胞質内精子注入法に特化した精子選択法・精子評価法の確立と治療前診断への応用

    • Principal Investigator
      菅沼 亮太
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Fukushima Medical University
  •  Possibility of preemptive medicine for cardiovascular disease in women with endometriosis: a clinical epidemiology approach

    • Principal Investigator
      Mizunuma Hideki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Fukushima Medical University
  •  Development of a new treatment for the deterioration of egg quality by aging based on mitochondrial quality controlPrincipal Investigator

    • Principal Investigator
      Takahashi Toshifumi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Fukushima Medical University
  •  Therapeutic strategy for reproductive aged women by regulation of oxidative stress and endoprasmic reticulum stress

    • Principal Investigator
      IGARASHI Hideki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  The possibility of 3D porous scaffold honeycomb films for the new strategy of treatment with ovarian cancer

    • Principal Investigator
      OHTA Tsuyoshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  Development of treatment strategy for age-related decline in oocyte quality by analyzing lipid metabolismPrincipal Investigator

    • Principal Investigator
      Takahashi Toshifumi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  The role of epigenetic effector polycomb group gene in ovarian cancers

    • Principal Investigator
      SUDO Takeshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  The identification of drug resistance in ovarian cancer : new insights form metabolomics and autophagy

    • Principal Investigator
      KURACHI HIROHISA
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  Molecular mechanism of aging-related decline in oocyte quality: a study of metabolomics and autophagyPrincipal Investigator

    • Principal Investigator
      TAKAHASHI Toshifumi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  Analysis of regulation of the inducible nitric oxide synthase geneby estrogen receptor alpha and beta

    • Principal Investigator
      TSUTSUMI Seiji
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  Study of rejuvenation of aged oocyte "Aim at the establishment of the strategy of a new fertility treatment"

    • Principal Investigator
      IGARASHI Hideki
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  Differential regulation of the inducible nitric oxide synthase gene by estrogen receptors αand β

    • Principal Investigator
      TSUTSUMI Seiji
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  Study ofion channels involved in uterine smooth muscle cells contraction by using molecular physiological approachPrincipal Investigator

    • Principal Investigator
      TAKAHASHI Toshifumi, 手塚 尚広
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  Crosstalk between estrogen receptor and transcriptional factors in the presence of SERMPrincipal Investigator

    • Principal Investigator
      KOJIMAHARA Takanobu, 高橋 俊文
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  DYNAMICS OF ION CHANNEL EXPRESSION IN PREGNANT RAT MYOMETRIUM : ANALYSIS MOLECULAR PHYSIOLOGICAL

    • Principal Investigator
      TEZUKA Naohiro
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  ガラス化法による女性配偶子の凍結保存に関する研究Principal Investigator

    • Principal Investigator
      高橋 俊文
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  Study of factors regulating the development of follicles, oocytes and embryos

    • Principal Investigator
      SAITO Hidekazu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  Studies on the regulatory mechanism of interaction between the development of ovulatry follicle and ovum in the ovary.

    • Principal Investigator
      HIROI Masahiko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      YAMAGATA UNIVERSITY

All 2020 2019 2017 2016 2015 2013 2012 2011 2010 2008 2007 2005 Other

All Journal Article Presentation

  • [Journal Article] The number of overall hysterectomies per population with the perimenopausal status is increasing in Japan: A national representative cohort study2020

    • Author(s)
      Isobe Masanori、Kataoka Yuki、Chikazawa Kenro、Nishigori Hiroshi、Takahashi Toshifumi、Enomoto Takayuki
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 46 Pages: 2651-2661

    • DOI

      10.1111/jog.14517

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K10486
  • [Journal Article] Correlation between the number of laparoscopy‐qualified gynecologists and the proportion of laparoscopic surgeries for benign gynecological diseases in Japan: An ecological study2020

    • Author(s)
      Isobe Masanori、Kataoka Yuki、Chikazawa Kenro、Hada Tomonori、Nishigori Hiroshi、Takahashi Toshifumi、Enomoto Takayuki
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 47 Pages: 329-336

    • DOI

      10.1111/jog.14528

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K10486
  • [Journal Article] Poor embryo development in post-ovulatoryin vivo-aged mouse oocytes is associated with mitochondrial dysfunction, but mitochondrial transfer from somatic cells is not sufficient for rejuvenation2016

    • Author(s)
      Igarashi H, Takahashi T, Abe H, Nakano H, Nakajima O, Nagase S
    • Journal Title

      Human Reproduction

      Volume: 31 Pages: 23331-23338

    • DOI

      10.1093/humrep/dew203

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462474, KAKENHI-PROJECT-16K11080, KAKENHI-PROJECT-16H03189
  • [Journal Article] Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies2015

    • Author(s)
      Igarashi, Hideki Takahashi, Toshifumi Nagase, Satoru
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 14 Pages: 159-169

    • DOI

      10.1007/s12522-015-0209-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462474
  • [Journal Article] miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression.2013

    • Author(s)
      Ohyagi-Hara C, Sawada K, Mabuchi S, Takahashi T, Kurachi H.(他12名、15番目)
    • Journal Title

      Am J Pathol

      Volume: 182 Pages: 1876-1889

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390308
  • [Journal Article] Non-sex Cord-stromal ovarian tumors frequently produce and secrete estrogen in postmenopausal women: impact on bone metabolism and abnormal endometrial histology.2013

    • Author(s)
      Matsumura S, Ohta T, Takahashi T, T Kurachi H
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: 98(7) Pages: 2775-2782

    • DOI

      10.1210/jc.2013-1267

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-24659723, KAKENHI-PROJECT-24791680, KAKENHI-PROJECT-25340047
  • [Journal Article] Non-sex cord-stromal ovarian tumors frequently produce and secrete estrogen in postmenopausal women:impact on bone metabolism and abnormal endometrial histology.2013

    • Author(s)
      Matsumura S, Ohta T, Takahashi T, T Kurachi H. (他2名、6番目)
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 98 Pages: 2775-2782

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390308
  • [Journal Article] MiR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression.2013

    • Author(s)
      Ohyagi-Hara C, Sawada K, Kamiura S, Tomita Y, Isobe A, Hashimoto K, Kinose Y, Mabuchi S, Hisamatsu T, Takahashi T, Kumasawa K, Nagata S, Morishige K-I, Lengyel E, Kurachi H, Kimura T.
    • Journal Title

      Am J Pathol

      Volume: in press

    • Data Source
      KAKENHI-PROJECT-22390308
  • [Journal Article] Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells.2013

    • Author(s)
      Ohta T, Takahashi T, Kurachi H
    • Journal Title

      Cancer Biol Ther

      Volume: 13(7) Pages: 25-33

    • DOI

      10.4161/cbt.13.1.18440

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-24659723, KAKENHI-PROJECT-24791680
  • [Journal Article] Estradiol and raloxifene induce the proliferation of osteoblasts through G-protein-coupled receptor GPR30.2013

    • Author(s)
      Ohyagi-Hara C, Sawada K, Mabuchi S, Takahashi T, Kurachi H
    • Journal Title

      Am J Pathol.

      Volume: 182(5) Pages: 1876-1889

    • DOI

      10.1016/j.ajpath.2013.01.039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-23592443, KAKENHI-PROJECT-23592447, KAKENHI-PROJECT-23890102, KAKENHI-PROJECT-24249080, KAKENHI-PROJECT-24590459, KAKENHI-PROJECT-24659723, KAKENHI-PROJECT-25293342, KAKENHI-PROJECT-25462588
  • [Journal Article] [妊孕能を考える]卵の加齢2012

    • Author(s)
      高橋俊文、高橋可菜子、倉智博久
    • Journal Title

      産婦人科の実際

      Volume: 61 Pages: 1885-1890

    • Data Source
      KAKENHI-PROJECT-22591815
  • [Journal Article] Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells.2012

    • Author(s)
      Ohta T, Takahashi T, Kurachi H
    • Journal Title

      Cancer Biol Ther

      Volume: 13(6) Pages: 408-16

    • DOI

      10.4161/cbt.19292

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-24659723, KAKENHI-PROJECT-24791680
  • [Journal Article] 酸化ストレスと卵の加齢2012

    • Author(s)
      高橋俊文、石田博美、倉智博久
    • Journal Title

      HORMONE FRONTIER INGYNECOLOGY

      Volume: 19 Pages: 149-155

    • Data Source
      KAKENHI-PROJECT-22591815
  • [Journal Article] 婦人科腫瘍との鑑別が困難であったGISTの2例.2012

    • Author(s)
      松村創平,太田 剛,水谷雅臣,蜂谷 修,木村 理,菅井幸雄,高橋一広,倉智博久.
    • Journal Title

      臨床婦人科産科

      Volume: 66(9) Pages: 799-802

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390308
  • [Journal Article] Estrogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells2011

    • Author(s)
      高橋一広、堤誠司、倉智博久, 他
    • Journal Title

      Mol Cell Neurosci

      Volume: 48 Pages: 217-224

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592121
  • [Journal Article] The activity of trabectedin as a single agent or in combination with everolimus for clear cell carcinoma of the ovary2011

    • Author(s)
      Mabuchi S, Sawada K, Takahashi T, Kurachi H
    • Journal Title

      Clin Cancer Res

      Volume: 17(13) Pages: 4462-4473

    • DOI

      10.1158/1078-0432.ccr-10-2987

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-23890101, KAKENHI-PROJECT-24659723
  • [Journal Article] Cellular and molecular mechanisms of various types of oocyteaging2011

    • Author(s)
      Takahashi T, Igarashi H, Amita M, Hara S, Kurachi H.
    • Journal Title

      Reprod Med Biol

      Volume: 10 Pages: 239-249

    • DOI

      10.1007/s12522-011-0099-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591815
  • [Journal Article] 母体の加齢による卵の加齢のメカニズム2011

    • Author(s)
      高橋俊文、前川絢子、倉智博久
    • Journal Title

      産科と婦人科

      Volume: 78 Pages: 929-934

    • Data Source
      KAKENHI-PROJECT-22591815
  • [Journal Article] Estrogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells2011

    • Author(s)
      Takahashi K, Piao S, Yamatani H, Du B, Yin L, Ohta T, Kawagoe J, Takata K, Tsutsumi S, Kurachi H
    • Journal Title

      Mol Cell Neurosci

      Volume: 48 Pages: 217-224

    • DOI

      10.1016/j.mcn.2011.08.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390308
  • [Journal Article] Estrogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells2011

    • Author(s)
      Takahashi K, Piao S, Yamatani H, Du B, Yin L, Ohta T, Kawagoe J, Takata K, Tsutsumi S, Kurachi H.
    • Journal Title

      Mol Cell Neurosci

      Volume: 48 Pages: 217-24

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592121
  • [Journal Article] Effect of dienogest on estrogen-induced nitric oxide production in human umbilical vein endothelial cell and endothelium-dependent vasodilatation in postmenopausal women.2010

    • Author(s)
      堤誠司、高橋俊文、倉智博久, 他
    • Journal Title

      Menopause

      Volume: 17 Pages: 615-621

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592121
  • [Journal Article] Roles of prostagrandins during oocytes maturation : lessons from knockout mice.2010

    • Author(s)
      Takahashi T, Igarashi H, Amita M, Hara S, Kurachi H
    • Journal Title

      J Mamm Ova Res 27

      Pages: 11-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591905
  • [Journal Article] Effect of dienogest on estrogen-induced nitric oxide production in human umbilical vein endothelial cells and endothelium-dependent vasodilatation in postmenopausal women2010

    • Author(s)
      Henmi N, Takahashi K, Amita M, Takata K, Ohta T, Tsutsumi S, Takahashi T, Kurachi H.
    • Journal Title

      Menopause

      Volume: 17 Pages: 615-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592121
  • [Journal Article] Usefulness of Bezafibrate for Ovulation Induction in Clomiphene Citrate-Resistant Polycystic Ovary Syndrome Patients with Dyslipidemia : A Prospective Pilot study of Seven Cases.2010

    • Author(s)
      Hara S, Takahashi T, Amita M, Igarashi H, Kurachi H
    • Journal Title

      Gynecol Obstet Invest. 16

      Pages: 166-172

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591905
  • [Journal Article] Usefulness of Bezafibrate for Ovulation Induction in Clomiphene Citrate-Resistant Polycystic Ovary Syndrome Patients with Dyslipidemia : A Prospective Pilot Study of Seven Cases.2010

    • Author(s)
      Shuichiro Hara, Toshifumi Takahashi, Mitsuyoshi Amita, Hideki Igarashi, Hirohisa Kurachi
    • Journal Title

      Gynecol Obstet Invest.

      Volume: 70 Pages: 166-172

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591905
  • [Journal Article] Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate2010

    • Author(s)
      Amita M, Takahashi T, Tsutsumi S, Ohta T, Takata K, Henmi N, Hara S, Igarashi H, Takahashi K, Kurachi H.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 394-405

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592121
  • [Journal Article] Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate.2010

    • Author(s)
      堤誠司、高橋俊文、倉智博久, 他
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 394-405

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592121
  • [Journal Article] Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate2010

    • Author(s)
      Amita M, Takahashi T, Ohta T, Takata K, Kurachi H
    • Journal Title

      Endocrinology

      Volume: 151(1) Pages: 394-405

    • DOI

      10.1210/en.2009-0721

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-24659723
  • [Journal Article] Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate.2010

    • Author(s)
      Amita M, Takahashi T, Tsutsumi S, Ohta T, Takata K, Henmi N, Hara S, Igarashi K, Takahashi K, Kurachi H.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 394-405

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390308
  • [Journal Article] Differential regulation of the induciblenitric oxide synthase gene by estrogen receptors 1 and 22008

    • Author(s)
      Tsutsumi S, Zhang X, Takata K, Takahashi K, Karas RH, Kurachi H. Mendelsohn ME.
    • Journal Title

      J Endocrinol 199(2)

      Pages: 267-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591922
  • [Journal Article] Mechanism of the divergent effects of estrogen on the cell proliferation of human umbilical endothelial versus aortismooth muscle cells2007

    • Author(s)
      Kawagoe J, Ohmichi M, Tsutsumi S, OhtaT, Takahashi K, Kurachi H.
    • Journal Title

      Endocrinology 148(12)

      Pages: 6092-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591922
  • [Journal Article] Raloxifene improves the ovariectomy-induced impairment in endothelium-dependent vasodilation2007

    • Author(s)
      Takahashi, K.
    • Journal Title

      Menopause 14

      Pages: 656-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591922
  • [Journal Article] Growth Factors Change Nuclear Distribution of Estrogen receptor-a via Mitogen-activated Protein Kinase or Phosphatidylinositol 3-kinase Cascade in a Human Breast Cancer Cell Line2005

    • Author(s)
      Takahashi T et al.
    • Journal Title

      Endocrinology 146

      Pages: 4082-44089

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591726
  • [Journal Article] Molecular mechanism of poor embryo development in postovulatory aged oocytes

    • Author(s)
      Takahashi T, Igarashi H, Amita M, Hara S, Koki M, Kurachi H.
    • Journal Title

      Mini review

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591815
  • [Presentation] Prevalence and predictive factors for complete fertilization failure in in vitro fertilization treatment cycles: a retrospective analysis of a large-scale nationwide database study2020

    • Author(s)
      Takahashi T, Ota K, Mizunuma H.
    • Organizer
      36th Annual Meeting ESHRE
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09976
  • [Presentation] Predictive factors for dizygotic twin pregnancies after single embryo transfer: a retrospective analysis of a large-scale nationwide database study2020

    • Author(s)
      Takahashi T, Ota K.
    • Organizer
      ASRM 2020 Scientific Congress & Expo
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09976
  • [Presentation] Predictive factors for dizygotic twin pregnancies after single embryo transfer: a retrospective analysis of a large-scale nationwide database study2019

    • Author(s)
      Takahashi T, Takehara I, Ota K, Mizunuma H, Nagase S
    • Organizer
      35th Annual Meeting ESHRE
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09976
  • [Presentation] Predictive factors for oocyte retrieval failure in treatment cycles with assisted reproductive technology: a retrospective cohort study using the nation-wide ART registry of Japan.2019

    • Author(s)
      Takahashi T, Ota K
    • Organizer
      ASRM 2019 Scientific Congress & Expo
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09976
  • [Presentation] Mitochondrial transfer from somatic cells is not sufficient for rejuvenation of postovulatory in vivo-aged mouse oocytes2017

    • Author(s)
      Igarashi H, Takahashi T, Abe H, Nakano H, Nakajima O, Nagase S, Kyono K
    • Organizer
      The 7th Congress of Asia Pacific Initiative on Reproduction
    • Place of Presentation
      Kuala Lumpur, Malaysia, Kuala Lumpur Convention Centre
    • Year and Date
      2017-03-30
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462474
  • [Presentation] MITOCHONDRIAL TRANSFER FROM SOMATIC CELLS IS NOT SUFFICIENT FOR REJUVENATION OF POSTOVULATORY IN VIVOAGED MOUSE OOCYTES2017

    • Author(s)
      Igarashi H, Takahashi T, Abe H, Nakano H, Nakajima O, Nagase S, Kyono K
    • Organizer
      The 7th Congress of the Asia Pacific Initiative on Reproduction
    • Place of Presentation
      Kuala Lumpur Convention Center, Kuala Lumpur, Malaysia
    • Year and Date
      2017-03-30
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11080
  • [Presentation] 2年前の膀胱癌由来と思われる腹膜偽粘液腫の1例2013

    • Author(s)
      小島原敬信, 高橋俊文, 松尾幸城, 松村創平, 小幡美由紀, 松川淳, 倉智博久
    • Organizer
      第65回日本産科婦人科学会
    • Place of Presentation
      札幌市教育文化会館(札幌市)
    • Data Source
      KAKENHI-PROJECT-22390308
  • [Presentation] 2年前の膀胱癌由来と思われる腹膜偽粘液腫の1例.2013

    • Author(s)
      小島原敬信, 高橋俊文, 松尾幸城, 松村創平, 小幡美由紀, 松川 淳, 倉智博久.
    • Organizer
      第65回日本産科婦人科学会
    • Place of Presentation
      札幌市教育文化会館(札幌市)
    • Data Source
      KAKENHI-PROJECT-22390308
  • [Presentation] 卵の加齢の分子機構2012

    • Author(s)
      高橋俊文
    • Organizer
      第64回日本産科婦人科学会
    • Place of Presentation
      神戸ポートピアホテルおよび神戸国際展示場(神戸市)
    • Year and Date
      2012-04-13
    • Data Source
      KAKENHI-PROJECT-22591815
  • [Presentation] 術後に卵巣小細胞癌と子宮体癌の重複癌と判明した一例.2012

    • Author(s)
      松村創平,高橋俊文,倉智博久.
    • Organizer
      第133回東北連合産科婦人科学会
    • Place of Presentation
      秋田
    • Data Source
      KAKENHI-PROJECT-22390308
  • [Presentation] 術後多発肺転移をきたした類上皮栄養膜細胞腫瘍の一症例2011

    • Author(s)
      須藤毅, 小島原敬信, 成味恵, 清野学, 高橋一広, 中原健次, 倉智博久, 本山悌一
    • Organizer
      第50回日本産科腫瘍学会
    • Place of Presentation
      札幌コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-22390308
  • [Presentation] 卵加齢メカニズムの新しい概念:マウス卵の加齢に小胞体ストレスが関与する2011

    • Author(s)
      五十嵐秀樹、網田光善、原周一郎、堤誠司、高橋俊文、倉智博久
    • Organizer
      第63回日本産科婦人科学会
    • Place of Presentation
      リーガロイヤルホテル大阪および大阪国際会議場(大阪市)
    • Year and Date
      2011-08-29
    • Data Source
      KAKENHI-PROJECT-22591815
  • [Presentation] 卵のagingと酸化ストレス2011

    • Author(s)
      高橋俊文
    • Organizer
      第29回日本受精着床学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-09-09
    • Data Source
      KAKENHI-PROJECT-22591815
  • [Presentation] 卵の加齢メカニズムにおける小胞体ストレスの関与についての検討2011

    • Author(s)
      五十嵐秀樹、高橋俊文、原周一郎、松尾幸城、倉智博久
    • Organizer
      第56回日本生殖医学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-12-08
    • Data Source
      KAKENHI-PROJECT-22591815
  • [Presentation] GFP-ERαを用いた子宮内膜細胞におけるエストロゲン・抗エストロゲン作用の可視化2010

    • Author(s)
      網田光善, 高橋俊文, 原周一郎, 五十嵐秀樹, 倉智博久
    • Organizer
      第55回日本生殖医学会
    • Place of Presentation
      徳島あわぎんホール
    • Data Source
      KAKENHI-PROJECT-22390308
  • [Presentation] 化学療法後の卵巣癌再発巣におけるAktとERKの活性化は予後良好因子である2010

    • Author(s)
      清野 学, 太田剛, 高橋俊文, 逸見典子, 須藤毅, 本山悌一, 倉智博久
    • Organizer
      第62回日本産科婦人科学会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Data Source
      KAKENHI-PROJECT-22390308
  • [Presentation] 加齢マウスにおける卵の老化による胚発育悪化のメカニズム2010

    • Author(s)
      高橋俊文
    • Organizer
      第28回日本受精着床学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-07-28
    • Data Source
      KAKENHI-PROJECT-22591815
  • [Presentation] GFP結合ERαを用いた子宮内膜細胞におけるエストロゲン, 抗エストロゲン作用の可視化2010

    • Author(s)
      網田光善, 高橋俊文, 原周一郎, 五十嵐秀樹, 倉智博久
    • Organizer
      第62回日本産科婦人科学会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Data Source
      KAKENHI-PROJECT-22390308
  • [Presentation] マウス加齢卵における卵の質の改善を目的としたミトコンドリア移植の試み.2008

    • Author(s)
      五十嵐秀樹、高橋俊文、網田光善、倉智博久
    • Organizer
      第49回日本哺乳動物卵子学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-05-17
    • Data Source
      KAKENHI-PROJECT-20591905
  • [Presentation] マウス加齢卵におけるミトコンドリア機能の評価とミトコンドリア移植の試み2008

    • Author(s)
      五十嵐秀樹、高橋俊文、網田光善、倉智博久
    • Organizer
      第53回日本生殖医学会総会・学術講演会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-10-23
    • Data Source
      KAKENHI-PROJECT-20591905
  • [Presentation] Impact of endoplasmic reticulum stress on the postovulatory aging of the mouse oocyte

    • Author(s)
      H. Igarashi, T. Takahashi, M. Amita, A. Hasegawa
    • Organizer
      ASRM 2014
    • Place of Presentation
      Hawaii Convention Center (Honolulu, Hawaii)
    • Year and Date
      2014-10-18 – 2014-10-22
    • Data Source
      KAKENHI-PROJECT-26462474
  • [Presentation] 卵の加齢の分子機構

    • Author(s)
      高橋俊文
    • Organizer
      第64回日本産科婦人科学会
    • Place of Presentation
      神戸国際会議場
    • Invited
    • Data Source
      KAKENHI-PROJECT-22591815
  • 1.  KURACHI Hirohisa (40153366)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 34 results
  • 2.  IGARASHI Hideki (80333970)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 14 results
  • 3.  TSUTSUMI Seiji (50323168)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 8 results
  • 4.  OHTA Tsuyoshi (50375341)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 9 results
  • 5.  太田 邦明 (90424142)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  SUTOH Takeshi (70466605)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 7.  SAITO Takakazu (00272071)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  SAITO Hidekazu (90125766)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  AMITA Mitsuyoshi (30420061)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 10.  NAKAHARA Kenji (80250934)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  TEZUKA Naohiro (60261690)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  TAKAHASHI Kazuhiro (20292427)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 13.  KOJIMAHARA Takanobu (20344806)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  菅沼 亮太 (30528211)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  TAKATA Keiko (70375343)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 16.  MABUCHI Seiji (00452441)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 17.  SAWADA Kenjiro (00452392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 18.  HARA Shuichiro (10436230)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  MATSUO Koki (90594317)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  HIROI Masahiko (60018364)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  ITOH Mariko (40292429)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KAWACHIYA Satoshi (30322001)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  Mizunuma Hideki (10125875)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  太田 信彦 (40301072)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  鈴木 大輔 (90401851)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  神保 正利 (80750413)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  MIMURA Kazuya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  ISOBE Aki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  ABE Hiroyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  山崎 岳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  森重 健一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  橋本 香映
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  熊澤 惠一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  木村 正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  富田 裕彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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