Shimada Masayuki 島田昌之

… Alternative Names

SHIMADA Masayuki 島田昌之

島田昌幸シマダマサユキ

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Researcher Number	20314742
Other IDs
Affiliation (Current)	2025: 広島大学, 統合生命科学研究科(生), 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 広島大学, 統合生命科学研究科(生), 教授 2017 – 2019: 広島大学, 生物圏科学研究科, 教授 2018: 広島大学, 統合生命科学研究科, 教授 2013 – 2016: 広島大学, 生物圏科学研究科, 准教授 2007 – 2012: Hiroshima University, 大学院・生物圏科学研究科, 准教授 … More 2011: 広島大学, 生物圏科学研究科, 准教授 2006: 広島大学, 大学院生物圏科学研究科, 助教授 2005: 広島大, 助手 2002 – 2004: Animal reproduction, Graduate School of Biosphere Sciences, Assistant Professor, 大学院・生物圏科学研究科, 助手 2002: Animal reproduction, Graduate School of Biosphere Sciences, Assistant Professor 2000 – 2001: 広島大学, 生物生産学部, 助手 Less
Review Section/Research Field	Principal Investigator Applied animal science / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Basic Section 42010:Animal production science-related / Basic Section 42010:Animal production science-related / Veterinary medical science, Animal science, and related fields / Animal production science / Biological Sciences / Biological Sciences / Applied animal science Except Principal Investigator Basic Section 42010:Animal production science-related … More / Animal production science / Boundary agriculture / General fisheries / Applied animal science / Applied animal science / Zootechnical science/Grassland science Less
Keywords	Principal Investigator 卵巣 / 排卵 / 卵丘細胞 / 妊孕性 / 成長因子 / 遺伝子発現 / 受精 / 繁殖障害 / 卵 / 卵成熟 … More / 精子 / シグナル伝達 / 体外成熟培養 / プロジェステロン / 卵子 / ミトコンドリア / 慢性炎症 / 加齢 / 線維化 / 応用動物 / DNAメチル化 / 顆粒層細胞 / ライディッヒ細胞 / シグナル伝達経路 / 顆粒膜細胞 / IVM / 減数分裂 / siRNA / 自然免疫 / 遺伝子改変マウス / 性ステロイドホルモン / 代謝 / 間質 / 臓器完成 / 間葉系幹細胞 / 感染 / 酸化ストレス / 間質細胞 / 加齢化 / 免疫学 / 畜産学 / 発情周期 / 抗精子抗体 / 免疫応答 / 受精卵 / 免疫機構 / 卵管 / 子宮 / 卵巣機能 / 家畜繁殖 / エピジェネティクス / メチル化 / エピジェネティクス制御 / 卵胞発育 / クロマチン構造 / エピゲノム / レチノイン酸代謝 / 精子形成 / 局所性成長因子 / 精巣 / 生殖 / 2 / ERK1 / neureulin 1 / 転写制御 / cAMP / sphingogosine 1 kinase / neuregulin 1 / プロスタグランジン / プロテアーゼ / エキソサイトーシス / サイトカイン / 内分泌 / マイクロアレイ / コレステロール合成 / タンパク分解酵素 / プロジェステロン受容体 / ブタ卵子 / LH / 発生工学 / LH受容体 / 体外受精 / 体外成熟 / ブタ … More Except Principal Investigator ウシ / 精子 / 卵成熟 / TLR2 / 受胎 / 受精卵 / 子宮 / 卵巣 / 排卵 / 卵胞発育 / 卵子 / 内在性レトロウイルス / トロホブラスト / 胎盤 / 免疫反応 / IFNT / 免疫寛容 / メチル化 / 代謝能 / 鉄 / 鉄イオン / エピゲノム / 生殖生理学 / エピゲノム修飾 / エピジェネティック制御 / トランスフェリン / 卵子成熟 / 免疫 / 妊娠 / 乳牛 / 免疫システム / 初期胚 / 免疫細胞 / 受胎性 / 免疫応答 / 配偶子 / 卵管 / extracellular matrix / ovary / progesterone / feces / sex differentiation / vasculogenesis / retinoic acid / estrogen / 雄特異的遺伝子 / rolB / シロイヌナズナ / トランスジェニックメダカ / エストロゲン受容体 / エストロンサルフェート / ノニルフェノール / 細胞外マトリックス / プロジェステロン / 糞 / 性分化 / 血管形成 / レチノイン酸 / エストロゲン / Stock contribution / Mating / Gonad development / Growth / Genetic tag / Microsatellite / Stock efficiency / Black sea bream / DNAフィンガープリント / 遺伝的多様性 / 遺伝標織 / 親子鑑定 / 放流種苗 / マイクロサテライトマーカー / 資源添加 / 繁殖 / 生殖腺 / 成長 / 遺伝標識 / マイクロサテライト / 放流効果 / クロダイ / Seminal plasma / Intracellular ice / Cryoresistance / Cyclodextrin / Cholesterol in sperm membrane / Fluidity of sperm membrane / Cryopreservation / Spermatozoa / 細胞膜 / Methyl-beta-cyclodextrin / 2-Hydropropyl-beta-cyclodextrin / 先体 / 凍結用希釈液 / 浸透圧 / 卵胞液 / コレステロール / ブタ / 温度衝撃 / 凍結障害 / 精漿 / 細胞内結晶 / 耐凍性 / サイクロデキストリン / 膜のコレステロール / 膜の流動性 / 凍結保存 / 体外成熟培養法 / ANNEXIN / 体外成熟培養 / Neurotensin / EGF-like factor / ADAM17 / ミトコンドリア配置制御因子 / ギャップ結合制御因子 / IVMFC技術 / 体外成熟卵子 / dbcAMP / 中心小体周辺物質 / 紡錘体 / Akt / 発生能力 / 受精能 / ミトコンドリア / ギャップ結合 / IVMFC 技術 / 微小器官動態 / プロラクチン受容体発現量 / プロテインキナーゼ活性 / プロラクチン感受性 / 乳腺細胞 / 夏季乾乳 / 乳生産 Less

Elucidation of the differentiation mechanism of bovine placental cells focusing on the intracellular energy metabolism system
- Principal Investigator
  
  草間和哉
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Study of the Mechanism of Ovarian Maturation Focusing on Gradual Cellular Composition Changes in the StromPrincipal Investigator
- Principal Investigator
  
  島田昌之
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Hiroshima University
Mechanism of amplifying the immune tolerance toward pregnancy in the cow by the innate immune receptor TLR2 in sperm and embryo
- Principal Investigator
  
  宮本明夫
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
The mechanisms of chronic inflammation in ovarian stromaPrincipal Investigator
- Principal Investigator
  
  島田昌之
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Hiroshima University
A mechasism for bovine maternal immune tolerance toward pregnancy via sensing sperm and embryo
- Principal Investigator
  
  Miyamoto Akio
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Analysis and application of follicular somatic cell-dependent oocyte metabolic regulation and epigenome regulation controled by iron during follicular development.
- Principal Investigator
  
  Yasuhisa Yamashita
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Prefectural University of Hiroshima
The study for understanding the mechanisms how MSCs induce ovarian agingPrincipal Investigator
- Principal Investigator
  
  Shimada Masayuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Hiroshima University
The development of prevention and treatemnt methods of fertilization failure from mice modelPrincipal Investigator
- Principal Investigator
  
  Shimada Masayuki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Veterinary medical science, Animal science, and related fields
- Research Institution
  Hiroshima University
Immune system of oviduct for very early pregnancy in dairy cattle: A crostalk between sperm/embryo and immune cells
- Principal Investigator
  
  Miyamoto Akio
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Animal production science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
The epigenetic regulation of follicular development by the expression of non-coding RNAPrincipal Investigator
- Principal Investigator
  
  Shimada Masayuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Animal production science
- Research Institution
  Hiroshima University
Exploration of oocyte maturation inducing factor by analysis of time-specific regulation of ADAM17 substrate specificity during follicular development and ovulation process.
- Principal Investigator
  
  Yamashita Yasuhisa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Animal production science
- Research Institution
  Prefectural University of Hiroshima
卵巣および精巣局所因子の発現，機能解析による配偶子形成機構の解明Principal Investigator
- Principal Investigator
  
  島田昌之
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
The molecular endocrinology analysis of early fertility decline mouse to develop the novel breeding marker of livestock animalsPrincipal Investigator
- Principal Investigator
  
  Shimada Masayuki
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Applied animal science
- Research Institution
  Hiroshima University
卵丘細胞のERKとPKB系に着目した哺乳動物卵子減数分裂再開制御因子の探索Principal Investigator
- Principal Investigator
  
  島田昌之
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
Next generation of IVMFC technical development by identification of the microtubule control factor of oocyte.
- Principal Investigator
  
  SATO Eimei
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied animal science
- Research Institution
  Tohoku University
The study for development of novel in vitro oocyte maturation technique generated from expression profile of micro-RNA during ovulation processPrincipal Investigator
- Principal Investigator
  
  SHIMADA Masayuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Applied animal science
- Research Institution
  Hiroshima University
The study for development of novel mammalian oocyte culture system generated from microarray data base of ovulating processPrincipal Investigator
- Principal Investigator
  
  SHIMADA Masayuki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Applied animal science
- Research Institution
  Hiroshima University
機能的LH受容体の発現誘導によるブタ体外成熟卵子の発生能向上に関する研究Principal Investigator
- Principal Investigator
  
  島田昌之
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied animal science
- Research Institution
  Hiroshima University
Environmental pollution by sex steroids and assessment for their effects on animals and plants
- Principal Investigator
  
  YAMASHITA Ichiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Boundary agriculture
- Research Institution
  HIROSHIMA UNIVERSITY
LH受容体発現解析によるブタ体外成熟卵子の発生能向上に関する生理・生化学的研究Principal Investigator
- Principal Investigator
  
  島田昌之
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied animal science
- Research Institution
  Hiroshima University
Contribution assessment of hatchery origin black sea bream Acanthopagrus schlegeli into natural populations using microsatellite markers
- Principal Investigator
  
  UMINO Tetsuya
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General fisheries
- Research Institution
  HIROSHIMA UNIVERSITY
暑熱の影響を受けた乳腺細胞のホルモン感受性の解析
- Principal Investigator
  
  藤田正範
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Zootechnical science/Grassland science
- Research Institution
  Hiroshima University
Physiological and biochemical studies on freezability boar spermatozoa
- Principal Investigator
  
  TERADA Takato
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  HIROSHIMA UNIVERSITY

[Book] 哺乳動物卵子の成熟と排卵のメカニズム（日本卵子学会胚培養士テキスト）2016
- Author(s)
  島田昌之、星野由美、山下泰尚
- Total Pages
  8
- Publisher
  日本卵子学会
- Data Source
  KAKENHI-PROJECT-26450381
[Book] Knobil and Neill’s Physiology of Reproduction 4th Edition2014
- Author(s)
  Richards JS, Liu Z, Shimada M
- Total Pages
  2503
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-24688028
[Book] Knobil and Neill’s Physiology of Reproduction 4th Edition2014
- Author(s)
  Richards JS, Liu Z, Shimada M
- Total Pages
  2503
- Publisher
  Academic Press
- Data Source
  KAKENHI-PUBLICLY-25132708
[Book] Oocyte Physiology and Development in Domestic Animals2013
- Author(s)
  Masayuki Shimada
- Total Pages
  248
- Publisher
  Wiley
- Data Source
  KAKENHI-PROJECT-24688028
[Book] Oocyte Physiology and Development in Domestic Animal2013
- Author(s)
  Masayuki Shimada
- Total Pages
  248
- Publisher
  Wiley
- Data Source
  KAKENHI-PUBLICLY-25132708
[Book] 卵子学2011
- Author(s)
  森崇英、島田昌之
- Total Pages
  1187
- Publisher
  京大出版会
- Data Source
  KAKENHI-PROJECT-21688019
[Book] 卵子学2011
- Author(s)
  森崇英(総編集), 島田昌之(編集幹事)
- Total Pages
  1187
- Publisher
  京大出版会
- Data Source
  KAKENHI-PROJECT-21688019
[Book] New Impact on Protein Modifications in the Regulation of Reproductive System (Editor : Toshinobu Tokumoto)2005
- Author(s)
  M.Shimada
- Total Pages
  18
- Publisher
  Research Signpost
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] Testosterone-Induced Metabolic Changes in Seminal Vesicle Epithelial cells Alter Plasma Components to Enhance Sperm Fertility2024
- Author(s)
  Yamanaka Takahiro、Xiao Zimo、Tsujita Natsumi、Awad Mahmoud、Umehara Takashi、Shimada Masayuki
- Journal Title
  
  eLife
  
  Volume: -
- DOI
  10.7554/elife.95541.1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00361
[Journal Article] Neurotensin induces sustainable activation of the ErbB-ERK1/2 pathway, which is required for developmental competence of oocytes in mice2024
- Author(s)
  Okamoto Asako、Nakanishi Tomoya、Tonai Shingo、Shimada Masayuki、Yamashita Yasuhisa
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 23 Issue: 1
- DOI
  10.1002/rmb2.12571
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14984, KAKENHI-PROJECT-23H00361
[Journal Article] Effect of globin peptide on female fertility in aging granulosa cell-specific <i>Nrg1</i> knockout mice2024
- Author(s)
  UMEHARA Takashi、OGASAHARA Marino、PREMARATHNE D.M.V. Supun、SASAKAWA Yuka、SUMIDA Yasuo、SHIMADA Masayuki
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 70 Issue: 3 Pages: 202-206
- DOI
  10.1262/jrd.2023-076
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23H00361
[Journal Article] Activation of sperm Toll-like receptor 2 induces hyperactivation to enhance the penetration to mucus and uterine glands: a trigger for the uterine inflammatory cascade in cattle2023
- Author(s)
  Akthar Ihshan、Kim Yejin、Umehara Takashi、Kanno Chihiro、Sasaki Motoki、Marey Mohamed Ali、Yousef Mohamed Samy、Haneda Shingo、Shimada Masayuki、Miyamoto Akio
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14
- DOI
  10.3389/fimmu.2023.1319572
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KF0018, KAKENHI-PROJECT-23K27049
[Journal Article] Toll-like receptor 2 is involved in Calcium influx and acrosome reaction to facilitate sperm penetration to oocytes during in vitro fertilization in cattle.2022
- Author(s)
  Ma D, Marey MA, Shimada M, Miyamoto A.
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 10 Pages: 810961-810961
- Open Access
- Data Source
  KAKENHI-PROJECT-20H03122
[Journal Article] Sperm interaction with the uterine innate immune system: toll-like receptor 2 (TLR2) is a main sensor in cattle2022
- Author(s)
  Akthar Ihshan、Marey Mohamed A.、Kim Yejin、Shimada Masayuki、Suarez Susan S.、Miyamoto Akio
- Journal Title
  
  Reproduction, Fertility and Development
  
  Volume: 34 Issue: 2 Pages: 139-148
- DOI
  10.1071/rd21265
- Open Access
- Data Source
  KAKENHI-PROJECT-20H03122
[Journal Article] Intrauterine infusion of low levels of interferon‐tau on day‐8 post‐estrus stimulates the bovine endometrium to secrete apolipoprotein‐A1: A possible implication for early embryo tolerance2022
- Author(s)
  Rashid Mohammad B.、Marey Mohamed A.、Fukuda Kenji、Haneda Shingo、Kusama Kazuya、Shimada Masayuki、Imakawa Kazuhiko、Miyamoto Akio
- Journal Title
  
  American Journal of Reproductive Immunology
  
  Volume: 88 Issue: 3
- DOI
  10.1111/aji.13592
- Open Access
- Data Source
  KAKENHI-PROJECT-20H03122
[Journal Article] Neutrophils recognize and amplify IFNT signals derived from day 7 bovine embryo for stimulation of ISGs expression in vitro: A possible implication for the early maternal recognition of pregnancy.2021
- Author(s)
  Fiorenza MF, Marey MA, Rashid MB, Zinnah MA, Ma D, Morillo VA, Kusama K, Shimada M, Imakawa K, Antoniazzi AQ, Miyamoto A.
- Journal Title
  
  Biochem Biophy Res Comm
  
  Volume: 553 Pages: 37-43
- Open Access
- Data Source
  KAKENHI-PROJECT-20H03122
[Journal Article] Day 7 embryos change the proteomics and exosomal micro-RNAs content of bovine uterine fluid: Involvement of innate immune functions.2021
- Author(s)
  Kusama K, Rashid MB, Kowsar R, Marey MA, Talukder AK, Nagaoka K, Shimada M, Khatib H, Imakawa K, Miyamoto A.
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 12 Pages: 676791-676791
- Open Access
- Data Source
  KAKENHI-PROJECT-20H03122
[Journal Article] Peptidoglycan Switches Off the TLR2-Mediated Sperm Recognition and Triggers Sperm Localization in the Bovine Endometrium2021
- Author(s)
  Elesh IF, Marey MA, Zinnah MA, Akhtar I, Kawai Naim TF, Goda W, Abou Rawash AR, Sasaki M, Shimada M, Miyamoto A.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 619408-619408
- DOI
  10.3389/fimmu.2020.619408
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03122
[Journal Article] Cortisol induces follicle regression, while FSH prevents cortisol-induced follicle regression in pigs2021
- Author(s)
  Nakanishi Tomoya、Okamoto Asako、Ikeda Maki、Tate Sachiko、Sumita Miyu、Kawamoto Rie、Tonai Shingo、Lee Joo Yeon、Shimada Masayuki、Yamashita Yasuhisa
- Journal Title
  
  Molecular Human Reproduction
  
  Volume: 27 Issue: 7 Pages: 99-99
- DOI
  10.1093/molehr/gaab038
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06359, KAKENHI-PROJECT-19H03108
[Journal Article] LH Induces De Novo Cholesterol Biosynthesis via SREBP Activation in Granulosa Cells During Ovulation in Female Mice2021
- Author(s)
  Nakanishi Tomoya、Tanaka Risa、Tonai Shingo、Lee Joo Yeon、Yamaoka Manami、Kawai Tomoko、Okamoto Asako、Shimada Masayuki、Yamashita Yasuhisa
- Journal Title
  
  Endocrinology
  
  Volume: 162 Issue: 11 Pages: 99-99
- DOI
  10.1210/endocr/bqab166
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06359, KAKENHI-PROJECT-19H03108
[Journal Article] Large-scale DNA demethylation occurs in proliferating ovarian granulosa cells during mouse follicular development.2021
- Author(s)
  Kawai T, Richards JS, Shimada M.
- Journal Title
  
  Commun Biol.
  
  Volume: 4 Issue: 1 Pages: 1334-1334
- DOI
  10.1038/s42003-021-02849-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14961, KAKENHI-PROJECT-19H03108
[Journal Article] Peptidoglycan disrupts early embryo-maternal crosstalk via suppression of ISGs expression induced by interferon-tau in the bovine endometrium2020
- Author(s)
  Zinnah MA, Marey MA, Akthar I, Elesh IF, Matsuno Y, Elweza AE, Ma DX, Fiorenza MF, Sasaki M, Shimada M, Imakawa K, Miyamoto A.
- Journal Title
  
  Biochem Biophy Res Comm
  
  Volume: 532 Issue: 1 Pages: 101-107
- DOI
  10.1016/j.bbrc.2020.08.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03122
[Journal Article] Sperm enter glands of preovulatory bovine endometrial explants and initiate inflammation2020
- Author(s)
  Akthar I, Suarez SS, Morillo VA, Sasaki M, Ezz MA, Takahashi KI, Shimada M, Marey MA, Miyamoto A.
- Journal Title
  
  Reproduction
  
  Volume: 159 Issue: 2 Pages: 181-192
- DOI
  10.1530/rep-19-0414
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05013, KAKENHI-PROJECT-17F17407, KAKENHI-PROJECT-18K19259
[Journal Article] Iron deficiency induces female infertile in order to failure of follicular development in mice2020
- Author(s)
  Tonai S, Kawabata A, Nakanishi T, Lee JY, Okamoto A, Shimada M, Yamashita Y.
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 66 Issue: 5 Pages: 475-483
- DOI
  10.1262/jrd.2020-074
- NAID
  130007925583
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06359, KAKENHI-PROJECT-19H03108
[Journal Article] Impact of lipopolysaccharide administration on luteinizing hormone/choriogonadotropin receptor (Lhcgr) expression in mouse ovaries.2020
- Author(s)
  Adetunji AO, Kawai T, Shimada M
- Journal Title
  
  J Reprod Immunol
  
  Volume: 142 Pages: 103193-103193
- DOI
  10.1016/j.jri.2020.103193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03108
[Journal Article] Methyl-beta cyclodextrin and creatine work synergistically under hypoxic conditions to improve the fertilization ability of boar ejaculated sperm.2020
- Author(s)
  Umehara T, Tsujita N, Goto M, Tonai S, Nakanishi T, Yamashita Y, Shimada M.
- Journal Title
  
  Animal Science Journal
  
  Volume: 91 Issue: 1
- DOI
  10.1111/asj.13493
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06359
[Journal Article] Pretreatment of ovaries with collagenase before vitrification keeps the ovarian reserve by maintaining cell-cell adhesion integrity in ovarian follicles.2020
- Author(s)
  Tomoko Kawai and Masayuki Shimada
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Issue: 1 Pages: 6841-6841
- DOI
  10.1038/s41598-020-63948-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03108
[Journal Article] Adverse effect of superoxide-induced mitochondrial damage in granulosa cells on follicular development in mouse ovaries.2020
- Author(s)
  Hoque SAM, Umehara T, Kawai T, Shimada M
- Journal Title
  
  Free Radic Biol Med.
  
  Volume: 163 Pages: 344-355
- DOI
  10.1016/j.freeradbiomed.2020.12.434
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03108, KAKENHI-PROJECT-21K14961
[Journal Article] Cutting the ovarian surface improves the responsiveness to exogenous hormonal treatment in aged mice.2020
- Author(s)
  Umehara T, Urabe N, Obata T, Yamaguchi T, Tanaka A, Shimada M.
- Journal Title
  
  Reprod Med Biol
  
  Volume: 19 Issue: 4 Pages: 415-424
- DOI
  10.1002/rmb2.12345
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03108
[Journal Article] Roadmap to pregnancy in the first 7 days post-insemination in the cow: Immune crosstalk in the corpus luteum, oviduct, and uterus2020
- Author(s)
  Talukder AK, Marey MA, Shirasuna K, Kusama K, Shimada M, Imakawa K, Miyamoto A.
- Journal Title
  
  Theriogenology
  
  Volume: 148 Pages: 313-320
- DOI
  10.1016/j.theriogenology.2020.01.071
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05013, KAKENHI-PROJECT-17F17407, KAKENHI-PROJECT-18K19259, KAKENHI-PROJECT-16H02584
[Journal Article] TLR2/4 signaling pathway mediates sperminduced inflammation in bovine endometrial epithelial cells in vitro.2019
- Author(s)
  Ezz MA, Marey MA, Elweza AE, Kawai T, Heppelmann M, Pfarrer C, Balboula AZ, Montaser A, Imakawa K, Zaabel SM, Shimada M, Miyamoto A.
- Journal Title
  
  PLoS ONE
  
  Volume: 14 Issue: 4 Pages: e0214516-e0214516
- DOI
  10.1371/journal.pone.0214516
- NAID
  120006644937
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19259, KAKENHI-PROJECT-17F17407, KAKENHI-PROJECT-16H05013, KAKENHI-PROJECT-16H02584
[Journal Article] Gene Expression and Protein Synthesis in Mitochondria Enhance the Duration of High-Speed Linear Motility in Boar Sperm2019
- Author(s)
  Zhu Zhendong、Umehara Takashi、Okazaki Tetsuji、Goto Masaaki、Fujita Yoko、Hoque S. A. Masudul、Kawai Tomoko、Zeng Wenxian、Shimada Masayuki
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 10 Pages: 252-252
- DOI
  10.3389/fphys.2019.00252
- NAID
  120006799358
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19324
[Journal Article] A proinflammatory response of bovine endometrial epithelial cells to active sperm in vitro.2018
- Author(s)
  Elweza AE, Ezz MA, Acosta TJ, Talukder AK, Shimizu T, Hayakawa H, Shimada M, Imakawa K, Zaghloul AH, Miyamoto A.
- Journal Title
  
  Mol Reprod Dev
  
  Volume: 85 Issue: 3 Pages: 215-226
- DOI
  10.1002/mrd.22955
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19324, KAKENHI-PROJECT-16H05013, KAKENHI-PROJECT-16H02584
[Journal Article] Oviduct epithelium induces interferon-tau in bovine Day-4 embryos, which generates an anti-inflammatory response in immune cells.2018
- Author(s)
  Talukder AK, Rashid MB, Yousef MS, Kusama K, Shimizu T, Shimada M, Suarez SS, Imakawa K, Miyamoto A.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 7580-7580
- DOI
  10.1038/s41598-018-26224-8
- NAID
  120006694201
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02584, KAKENHI-PROJECT-16H05013, KAKENHI-PROJECT-17K19324
[Journal Article] Evidence that interferon-tau secreted from Day-7 embryo in vivo generates anti-inflammatory immune response in the bovine uterus2018
- Author(s)
  Rashid MB, Talukder AK, Kusama K, Haneda S, Takedomi T, Yoshino H, Moriyasu S, Matsui M, Shimada M, Imakawa K, Miyamoto A.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 500 Issue: 4 Pages: 879-884
- DOI
  10.1016/j.bbrc.2018.04.178
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02584, KAKENHI-PROJECT-16H05013, KAKENHI-PROJECT-17K19324
[Journal Article] The Cell Type-Specific Expression of Lhcgr in Mouse Ovarian Cells: Evidence for a DNA-Demethylation-Dependent Mechanism.2018
- Author(s)
  Kawai T, Richards JS, Shimada M.
- Journal Title
  
  Endocrinology
  
  Volume: 159 Issue: 5 Pages: 2062-2074
- DOI
  10.1210/en.2018-00117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05017
[Journal Article] Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice.2018
- Author(s)
  Kitasaka H, Kawai T, Hoque SAM, Umehara T, Fujita Y, Shimada M.
- Journal Title
  
  Plos One
  
  Volume: 13
- NAID
  120006799356
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05017
[Journal Article] Mitochondrial Protein Turnover Is Critical for Granulosa Cell Proliferation and Differentiation in Antral Follicles2018
- Author(s)
  Hoque S A Masudul、Kawai Tomoko、Zhu Zhendong、Shimada Masayuki
- Journal Title
  
  Journal of the Endocrine Society
  
  Volume: 3 Issue: 2 Pages: 324-339
- DOI
  10.1210/js.2018-00329
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05017
[Journal Article] Creatine enhances the duration of sperm capacitation: a novel factor for improving in vitro fertilization with small numbers of sperm.2018
- Author(s)
  Umehara Takashi, Kawai1 Tomoko, Goto Masaaki, JoAnne S. Richards, Shimada Masayuki.
- Journal Title
  
  Human reproduction
  
  Volume: in press Issue: 6 Pages: 1117-1129
- DOI
  10.1093/humrep/dey081
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J05331, KAKENHI-PROJECT-16H05017, KAKENHI-PROJECT-17K19324
[Journal Article] The acceleration of reproductive aging in Nrg1flox/flox ;Cyp19-Cre female mice.2017
- Author(s)
  Umehara T, Kawai T, Kawashima I, Tanaka K, Okuda S, Kitasaka H, Richards JS, Shimada M.
- Journal Title
  
  Aging Cell.
  
  Volume: 16 Issue: 6 Pages: 1288-1299
- DOI
  10.1111/acel.12662
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20167, KAKENHI-PROJECT-16H05017, KAKENHI-PROJECT-15J05331
[Journal Article] Bovine embryo induces an anti-inflammatory response in uterine epithelial cells and immune cells <i>in vitro</i>: possible involvement of interferon tau as an intermediator2017
- Author(s)
  Fadhillah, Yoshioka S, Nishimura R, Kiyoshi Okuda
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 63 Issue: 4 Pages: 425-434
- DOI
  10.1262/jrd.2017-056
- NAID
  130005982816
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26292136, KAKENHI-PROJECT-16H05013
[Journal Article] Neuregulin 1 regulates proliferation of leydig cells to support spermatogenesis and sexual behavior in adult mice2016
- Author(s)
  Umehara T, Kawashima I, Kawai T, Hoshino Y, Morohashi KI, Shima Y, Richards JS, Shimada M
- Journal Title
  
  Endocrinology
  
  Volume: 157 Issue: 12 Pages: 4899-4913
- DOI
  10.1210/en.2016-1478
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05017, KAKENHI-PROJECT-16H05142, KAKENHI-PROJECT-15J05331, KAKENHI-PROJECT-15K20167
[Journal Article] Roles of epidermal growth factor (EGF)-like factor in the ovulation process2016
- Author(s)
  Masayuki Shimada , Takashi Umehara, Yumi Hoshino
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 15 Issue: 4 Pages: 1-16
- DOI
  10.1007/s12522-016-0236-x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15J05331, KAKENHI-PROJECT-24688028
[Journal Article] Developmental of artificial insemination technique in pig production based on the evidence of physiology and molecular biology in reproductive organs2016
- Author(s)
  Shimada M, Okazaki T, Yamashita Y.
- Journal Title
  
  Agri-Bioscience Monographs
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26450381
[Journal Article] The novel pig in vitro maturation system to improve developmental competence of oocytes derived from atretic non-vascularized follicle.2016
- Author(s)
  Okamoto A, Ikeda M, Kaneko A, Kishida C, Shimada M, Yamashita Y
- Journal Title
  
  Biology of Reproduction
  
  Volume: 95 Issue: 4 Pages: 1-16
- DOI
  10.1095/biolreprod.116.138982
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05017, KAKENHI-PROJECT-26450381
[Journal Article] Development of artificial insemination technique in pig production based on the evidence of physiology and molecular biology in reproductive organs.2016
- Author(s)
  Shimada M, Yamashita Y, Okazaki T.
- Journal Title
  
  Agri-Biosciene Monographs
  
  Volume: 6 Issue: 2 Pages: 59-83
- DOI
  10.5047/agbm.2016.00602.0059
- NAID
  40021125070
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26450381
[Journal Article] De novo-synthesized retinoic acid in ovarian antral follicles enhances FSH-mediated ovarian follicular cell differentiation and female fertility2016
- Author(s)
  Shimada M
- Journal Title
  
  Endocrinology
  
  Volume: in press Issue: 5 Pages: 2160-2172
- DOI
  10.1210/en.2015-2064
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24688028, KAKENHI-PROJECT-16H05017, KAKENHI-PROJECT-26660112
[Journal Article] The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice.2014
- Author(s)
  Nakagawa S, Shimada M, Yanaka K, Mito M, Arai T, Takahashi E, Fujita Y, Fujimori T, Standaert L, Marine JC, Hirose T.
- Journal Title
  
  Development
  
  Volume: 141 Issue: 23 Pages: 4618-27
- DOI
  10.1242/dev.110544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21116005, KAKENHI-PUBLICLY-25132708, KAKENHI-PLANNED-26113005, KAKENHI-PROJECT-26291001, KAKENHI-ORGANIZER-26113001, KAKENHI-PLANNED-26113002, KAKENHI-PROJECT-24688028
[Journal Article] The expression and roles of semaphorin type 3C in granulosa cells dureing the luteinization process2014
- Author(s)
  Okabe A, Hiramatsu R, Umehara T, Fujita Y, Shimada M
- Journal Title
  
  Journal of Mammlian Ova Research
  
  Volume: 31 Pages: 31-39
- NAID
  130004436880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24688028
[Journal Article] Protein kinase C (PKC) increases TACE/ADAM17 enzyme activity in porcine ovarian somatic cells, which is essential for granulosa cell luteinization and oocyte maturation.2014
- Author(s)
  Yamashita Y, Okamoto M, Ikeda M, Okamoto A, Sakai M, Gunji Y, Nishimura R, Hishinuma M, Shimada M
- Journal Title
  
  Ｅｎｄｏｃｒｉｎｏｌｏｇｙ
  
  Volume: 155 Issue: 3 Pages: 1080-1090
- DOI
  10.1210/en.2013-1655
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24688028, KAKENHI-PROJECT-24780271, KAKENHI-PUBLICLY-25132708
[Journal Article] The Expression and Roles of Semaphorin Type 3C in Granulosa Cells during The Luteinization Process2014
- Author(s)
  Okabe A, Hiramatsu R, Umehara T, Fujita Y, Shimada M.
- Journal Title
  
  Journal of Mammalian Ova Research
  
  Volume: 31 Issue: 1 Pages: 31-39
- DOI
  10.1274/jmor.31.31
- NAID
  130004436880
- ISSN
  1341-7738, 1347-5878
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25132708, KAKENHI-PROJECT-24688028
[Journal Article] Targeted disruption of Nrg1 in granulosa cells alters the temporal progression of oocyte maturation.2014
- Author(s)
  Kawashima et al
- Journal Title
  
  Molecular Endocrinology
  
  Volume: 28 Issue: 5 Pages: 706-721
- DOI
  10.1210/me.2013-1316
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J11037, KAKENHI-PROJECT-24688028, KAKENHI-PUBLICLY-25132708
[Journal Article] Protein kinase C (PKC) increases TACE/ADAM17 enzyme activity in porcine ovarian somatic cells, which is essential for granulosa cell luteinization and oocyte maturation.2014
- Author(s)
  Yamashita Y, Okamoto M, Ikeda M, Okamoto A, Sakai M, Gunji Y, Nishimura R, Hishinuma M, Shimada M.
- Journal Title
  
  Endocrinology
  
  Volume: 155(3) Pages: 1080-1090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26450381
[Journal Article] The Release of EGF Domain from EGF-like Factors by a Specific Cleavage Enzyme Activates the EGFR-MAPK3/1 Pathway in Both Granulosa Cells and Cumulus Cells During the Ovulation Process2012
- Author(s)
  Yamashita & Shimada
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 58 Issue: 5 Pages: 510-514
- DOI
  10.1262/jrd.2012-056
- NAID
  10031123293
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24688028, KAKENHI-PROJECT-24780271
[Journal Article] ERK1/ 2の活性化増強システムが,卵子成熟,卵丘細胞の膨潤,顆粒膜細胞の黄体化に必須である,2012
- Author(s)
  川島一公, 野間紀孝, Heng-Yu Fan, JoAnne S. Richards, 島田昌之
- Journal Title
  
  日本生殖内分泌学会誌
  
  Volume: 14巻 Pages: 35-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] Anti-bacterial factors secreted from cumulus cells of ovulated COCs enhance sperm capacitation during in vitro fertilization.2012
- Author(s)
  Shimada, et al.
- Journal Title
  
  Am. J. Reprod. Immunol.
  
  Volume: 69 Issue: 2 Pages: 168-179
- DOI
  10.1111/aji.12024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24688028
[Journal Article] The Positive Feedback Loop Between Prostaglandin E2 and EGF-Like Factors Is Essential for the Sustainable Activation of MAPK3/ 1 in Cumulus Cells During In Vitro Maturation of Porcine Cumulus-Oocyte Complexes2012
- Author(s)
  Y. Yamashita, M. Okamoto, I. Kawashima, T. Okazaki, R. Nishimura, Y. Gunji, M. Hishinuma, M. Shimada
- Journal Title
  
  Biol Reprod
  
  Volume: 85 Pages: 1073-1082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] Endogenous acetaldehyde toxicity during antral follicular development in the mouse ovary2012
- Author(s)
  Kawai T, Mihara T, Kawashima I, Fujita Y, Ikeda C, Negishi H, RichardsJS, Shimada M
- Journal Title
  
  Reprod Toxicol
  
  Volume: 33 Pages: 322-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] LHinduces Neuregulin 1(NRG1) type III specific transcripts that interact with EGF-like factor pathways to control granulosa cell differen tiation and oocyte maturation2011
- Author(s)
  N. Noma, I. Kawashima, H. Y. Fan, Y. Fujita, T. Kawai, Y. Tomoda, T. Mihara, J. S. Richards, M. Shimada
- Journal Title
  
  Mol. Endocrinol
  
  Volume: 25(1) Pages: 104-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] Toll-like receptors(TLR) 2 and 4 on human sperm recognize bacterial endotoxins and mediate apoptosis2011
- Author(s)
  Y. Fujita, T. Mihara, T. Okazaki, M. Shitanaka, R. Kushino, C. Ikeda, H. Negishi, Z. Liu, J. S. Richards, M. Shimada
- Journal Title
  
  Hum Reprod
  
  Volume: 26(10) Pages: 2799-2806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] The key signaling cascades in granulosa cells during follicular development and ovulation process2011
- Author(s)
  Shimada M
- Journal Title
  
  J Mamm Ova Res
  
  Volume: (In press)
- NAID
  10028124268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] The key signaling cascades in granulosa cells during follicular development and ovulation process2011
- Author(s)
  Shimada M
- Journal Title
  
  J Mamm Ova Res
  
  Volume: (In press)
- NAID
  10028124268
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21028014
[Journal Article] Th ekey signaling cascades in granulosa cells during follicular development and ovulation process2011
- Author(s)
  M. Shimada, Y. Yamashita
- Journal Title
  
  J Mamm Ova Res
  
  Volume: 28 Pages: 25-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] Possible involvement of phosphatidylinositol 3-kinase in the maintenance of metaphase II attest in porcine oocytes matured in vitro2010
- Author(s)
  J. Ito, M. Shimada, N. Kashiwazaki
- Journal Title
  
  Anim Sci J
  
  Volume: 81 Pages: 42-47
- NAID
  10027888464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] Murine sperm expresses Toll-like receptor(TLR) family that responds to the pathogens released from virus, and decreases fertilization ability by the stimuli2010
- Author(s)
  T. Mihara, K. Fukumoto, T. Okazaki, M. Shimada
- Journal Title
  
  J Mamm Ova Res
  
  Volume: 27 Pages: 136-143
- NAID
  130004436779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] 卵子卵丘細胞複合体と卵子形成2010
- Author(s)
  島田昌之
- Journal Title
  
  J Mamm Ova Res
  
  Volume: 26 Pages: 189-194
- NAID
  10026350030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] Progesterone is essential for maintenance of Tace/ Adam17 mRNA expression, but not EGF-like factor, incumulus cells, which enhances EGF receptor signaling pathway during in vitro maturation of porcine COCs2010
- Author(s)
  Y. Yamashita, I. Kawashima, Y. Gunji, M. Hishinuma, M. Shimada
- Journal Title
  
  J Reprod Dev
  
  Volume: 56(3) Pages: 315-323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] Cumulus cells are an essential mediator of ovulation stimuli from granulosa cells to oocyte2010
- Author(s)
  M. Shimada, J. S. Rochards
- Journal Title
  
  J Mamm Ova Res
  
  Volume: 27(1) Pages: 2-10
- NAID
  10026350251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] Cumulus cells are an essential mediator of ovulation stimuli from granulosa cells to oocyte (Review article)2010
- Author(s)
  Shimada M
- Journal Title
  
  J Mamm Ova Res (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21028014
[Journal Article] β-Catenin(CTNNB1) Promotes Preovulatory Follicular Development but Represses LH-Mediated Ovulation and Luteinization2010
- Author(s)
  H. Y. Fan, A. O' Connor, M. Shitanaka, M. Shimada, Z. Liu, J. S. Richards
- Journal Title
  
  Mol Endocrinol
  
  Volume: 24(8) Pages: 1529-1542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] Cumulus cells are an essential mediator of ovulation stimuli from granulosa cells to oocyte (Review article)2010
- Author(s)
  Shimada M
- Journal Title
  
  J Mamm Ova Res (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] Richards(2009) ERK1/ 2 inovarian granulosa cells are critical for female fertility2009
- Author(s)
  H. Y. Fan, Z. Liu, M. Shimada, E. Sterneck, P. F. Johnson, S. M. Hedrick, J. S
- Journal Title
  
  Science
  
  Volume: vol, 324 Pages: 938-941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] an autocrine regulator of the mouse cumulus cell-oocyte complex expansion process2009
- Author(s)
  Z. Liu, D. G. de Matos, H. Y. Fan, M. Shimada, S. Palmer, J. S. Richards
- Journal Title
  
  Endocrinology
  
  Volume: vol, 150(8) Pages: 3360-3368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] 卵子卵丘細胞複合体と卵子形成2009
- Author(s)
  島田昌之
- Journal Title
  
  J Mamm Ova Res 26
  
  Pages: 189-194
- NAID
  10026350030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] IL6: an autocrine regulator of the mouse cumulus cell-oocyte complex expansion process2009
- Author(s)
  Liu Z, de Matos DG, Fan HY, Shimada M, Palmer S, Richards JS
- Journal Title
  
  Endocrinology doi:10.1210/en
  
  Pages: 2008-1532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Activation of PKA, p38MAPK and ERK1/ 2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ ADAM17 gene expression during in vitro maturation of porcine COCs2009
- Author(s)
  Y. Yamashita, M. Hishinuma, M. Shimada
- Journal Title
  
  J Ova Res
  
  Volume: 2(1) Pages: 20-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21688019
[Journal Article] ERK1/2 in ovarian granulosa cells are critical for female fertility2009
- Author(s)
  Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick SM, Richards JS
- Journal Title
  
  Science 324
  
  Pages: 938-941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Sequential exposure of porcine cumulus cells to FSH and/or LH is critical for appropriate expression of steroidogenic and ovulation related genes that impact oocyte maturation in vivo and in vitro2008
- Author(s)
  Kawashima I, Okazaki T, Noma N, Nishibori M, Yamashita Y, Shimada M
- Journal Title
  
  Reproduction vol. 136 (1)
  
  Pages: 9-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Hormone-induced expression of TACE/ADAM17 protease impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the EGF receptor2008
- Author(s)
  Yamashita Y, Kawashima I, Yanai Y, Nishibori M, Richards JS, Shimada M
- Journal Title
  
  Endocrinology vol.148
  
  Pages: 6164-6175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Hyaluronan fragments generated by sperm-secreted hyaluronidase stimulate cytokines/chemokines production via TLR2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilization.2008
- Author(s)
  M. Shimada
- Journal Title
  
  Development 135・11
  
  Pages: 2001-2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Somatic Expression of K-rasG12D in mouse ovary causes defects of follicle development and ovulation2008
- Author(s)
  Fan HY, Shimada M, Liu Z, Cahill N, Noma N, Wu Y, Gossen J, Richards JS
- Journal Title
  
  Development vol. 135 (12)
  
  Pages: 2127-2137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] 卵子・卵丘細胞複合体-卵丘細胞による卵子成熟の制御機構-2008
- Author(s)
  島田昌之
- Journal Title
  
  産婦人科診療 96・1
  
  Pages: 18-24
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Hyaluronan fragments generated by sperm-secreted hyaluronidase stimula-te cytokines/chemokines production via TLR2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilization2008
- Author(s)
  Shimada M, Yanai Y, Okazaki T, Noma N, Kawashima I, Mori T, Richards JS
- Journal Title
  
  Development vol. 135 (11)
  
  Pages: 2001-2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] The Immune-like Mechanisms in Ovulation2008
- Author(s)
  Richards JS, Liu Z, Shimada M
- Journal Title
  
  Trend Endocrinol Metab vol. 19 (6)
  
  Pages: 191-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Synaptosomal associated protein 25 (Snap25) gene expression is hormonally regulated during ovulation and is involved in cytokine/chemokine exocytosis from granulosa cells2007
- Author(s)
  Shimada M, Yanai Y, Okazaki T, Yamashita Y, Sriraman Y, Wilson MC, Richards JS
- Journal Title
  
  Mol Endocrinol vol. 21(10)
  
  Pages: 2487-2502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Involvement of Ca^<2+>-dependent proteasome in the degradation of both cyclin B1 and Mos during spontaneous activation of matured rat oocytes2007
- Author(s)
  J.Ito, M.Shimada et al.4名中2番目
- Journal Title
  
  Theriogenology 67
  
  Pages: 475-485
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Assessment of human oocyte developmental competence by cumulus cell morphology and circulating hormone profile2007
- Author(s)
  C.Sato, M.Shimada et al.7名中2番目
- Journal Title
  
  Reproductive BioMedicine Online 14 (1)
  
  Pages: 49-56
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Synaptosonial-associated protein 25 gene expression is hormonally regulated during ovulation and is involved in cytokine/chemokine exocsrtosis from granulosa cells2007
- Author(s)
  M. Shimada
- Journal Title
  
  Molecular Endocrinology 21・10
  
  Pages: 2487-2502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Paracrine and autocrine regulation of epidermal growth factor-like factors in cumulus oocyte complexes and granulosa cells : Key roles for prostaglandin synthase 2 and progesterone receptor2006
- Author(s)
  M.Shimada et al.
- Journal Title
  
  Molecular Endocrinology 20(6)
  
  Pages: 1352-1365
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Induced expression of pattern recognition receptors (PRRs) in cumulus oocyte complexes (COCs) : Novel evidence for immune-like functions during ovulation2006
- Author(s)
  Shimada M, Hernandez-Gonzalez I, Gonzalez-Robayna I, Richards JS
- Journal Title
  
  Mol Endocrinol. vol. 20
  
  Pages: 3228-3239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Induced expression of pattern recognition receptors in cumulus oocyte complexes : Novel evidence for innate immune-like functions during ovulation2006
- Author(s)
  M.Shimada et al.
- Journal Title
  
  Molecular Endocrinology 20(12)
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Gene expression profiles of cumulus cell oocyte complexes during ovulation reveal cumulus cells express neuronal and immune-related genes : Does this expand their role in the ovulation process?2006
- Author(s)
  I, Hernandez-Gonzalez, M. Shimada et al. 7名中3番目
- Journal Title
  
  Molecular Endocrinology 20(6)
  
  Pages: 1300-1321
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] Paracrine and autocrine regulation of EGF-like factors in cumulus oocyte complexes (COCs) and granulosa cells : key roles for prostanglandin synthase 2 (Ptgs2) and progesterone receptor (Pgr)2006
- Author(s)
  Shimada M, Hernandez-Gonzalez I, Gonzalez-Robayna I, Richards JS
- Journal Title
  
  Mol Endocrinol. Vol.20 (6)
  
  Pages: 1352-1365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18688016
[Journal Article] The gonadotropin-induced cumulus cell differentiations play important roles in in vitro meiotic maturation of porcine oocytes2005
- Author(s)
  M.Shimada
- Journal Title
  
  New Impact on Protein Modifications in the Regulation of Reproductive System (Editor : Toshinobu Tokumoto)(published by Research Signpost)
  
  Pages: 1-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] Effects of adding LH to FSH-containing medium on progesterone-induced differentiation of cumulus cells during meiotic resumption of porcine oocytes2005
- Author(s)
  M.Shimada
- Journal Title
  
  Animal Science Journal 75(6)
  
  Pages: 515-524
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] Effects of adding LH to FSH-containing medium on progesterone-induced differentiation of cumulus cells during meiotic resumption of porcine oocytes2005
- Author(s)
  M.Shimada
- Journal Title
  
  Animal Science Journal (In press)
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] Effects of adding LH to FSH-containing medium on progesterone-induced differentiation of cumulus cells during meiotic resumption of porcine oocytes2005
- Author(s)
  M.Shimada
- Journal Title
  
  Anim Sci J 75
  
  Pages: 515-524
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] Expression of two progesterone receptor isoforms in cumulus cells and their roles during meiotic resumption of porcine oocytes2004
- Author(s)
  M.Shimada
- Journal Title
  
  Journal of Molecular Endocrinology 33
  
  Pages: 209-215
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] FSH-induced Activation of PI 3-kinase-PKB Pathway is Essential for LH Receptor Formation in Cumulus Cells during Meiotic Resumption of Porcine Oocytes2004
- Author(s)
  Shimada M.
- Journal Title
  
  Jap J Reprod Endocrinol 9
  
  Pages: 49-55
- NAID
  40006844914
- Data Source
  KAKENHI-PROJECT-16780195
[Journal Article] FSH-induced activation of PI 3-kinase-PKB pathway is essential for LH receptor formation in cumulus cells during meiotic resumption of porcine oocytes.2004
- Author(s)
  M.Shimada
- Journal Title
  
  Jap J Reprod Endoc 9
  
  Pages: 49-55
- NAID
  40006844914
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] FSH-induced activation of PI 3-kinase-PKB pathway is essential for LH receptor formation in cumulus cells during meiotic resumption of porcine oocytes2004
- Author(s)
  M.Shimada
- Journal Title
  
  Japanese Journal of Reproductive Endocrinology (In press)
- NAID
  40006844914
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] Down-regulated expression of A disintegrin and metalloproteinase with thrombospondin-like repeats-1 by progesterone receptor antagonist is associated with impaired expansion of pocine COCs.2004
- Author(s)
  Shimada M.
- Journal Title
  
  Endocrinology 145(10)
  
  Pages: 4603-4614
- Data Source
  KAKENHI-PROJECT-16780195
[Journal Article] Effects of adding luteinizing hormone to a medium containing follicle stimulating hormone on progesterone-induced differentiation of cumulus cells during meiotic resumption of porcine oocytes2004
- Author(s)
  Shimada M.
- Journal Title
  
  Anim Sci J 75(6)
  
  Pages: 515-524
- NAID
  10018625080
- Data Source
  KAKENHI-PROJECT-16780195
[Journal Article] Expression of two progesterone receptor isoforms in cumulus cells and their roles during meiotic resumption of porcine oocytes2004
- Author(s)
  M.Shimada
- Journal Title
  
  J Mol Endocrinol 33
  
  Pages: 209-225
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] FSH-induced activation of PI 3-kinase-PKB pathway is essential for LH receptor formation in cumulus cells during meiotic resumption of porcine oocytes2004
- Author(s)
  M.Shimada
- Journal Title
  
  Japanese Journal of Reproductive Endocrinology 9
  
  Pages: 49-55
- NAID
  40006844914
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] Down-regulated expression of a disintegrin and metalloproteinase with thrombospondin-like repeats-1 by progesterone receptor antagonist is associated2004
- Author(s)
  M.Shimada
- Journal Title
  
  Endocrinology 145
  
  Pages: 4603-4614
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] Down-regulated expression of a disintegrin and metalloproteinase with thrombospondin-like repeats-1 by progesterone receptor antagonist is associated with impaired expansion of porcine cumulus-oocyte complexes.2004
- Author(s)
  M.Shimada
- Journal Title
  
  Endocrinology 145
  
  Pages: 4603-4614
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] Expression of two progesterone receptor isoforms in cumulus cells and their roles during meiotic resumption of porcine oocytes2004
- Author(s)
  Shimada M.
- Journal Title
  
  J Mol Endocrinol 33(1)
  
  Pages: 209-225
- Data Source
  KAKENHI-PROJECT-16780195
[Journal Article] Time dependent changes in progesterone receptor expression in cumulus cells during meiotic resumption of porcine oocytes2003
- Author(s)
  M.Shimada
- Journal Title
  
  J Mamm Ova Res 20
  
  Pages: 113-117
- NAID
  10012455097
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380222
[Journal Article] Time dependent changes in progesterone receptor expression in cumulus cells during meiotic resumption of porcine oocytes2003
- Author(s)
  M.Shimada
- Journal Title
  
  Journal of Mammalian Ova Research 20
  
  Pages: 113-117
- NAID
  10012455097
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380222
[Presentation] 精嚢腺上皮細胞における代謝関連遺伝子群の発現変動が，精子の受精能を向上させる2023
- Author(s)
  山中貴寛, 梅原崇，辻田菜摘, 島田昌之
- Organizer
  日本受精着床学会
- Data Source
  KAKENHI-PROJECT-23H00361
[Presentation] Metabolic Decline of Ovarian Stromal Cells with Aging: Inducing Ovarian Fibrosis and Inhibiting Follicular Development2023
- Author(s)
  島田昌之
- Organizer
  日本生殖医学会　KSRM-JSRM joint session
- Invited
- Data Source
  KAKENHI-PROJECT-23H00361
[Presentation] 間葉系幹(間質)細胞に着眼した新たな人工授精／体外受精法開発の試み2023
- Author(s)
  島田昌之
- Organizer
  日本IVF学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23H00361
[Presentation] Testosterone-induced metabolism-related genes in seminal vesicle impact on the quality of seminal plasma for improving sperm fertilization ability in mice2023
- Author(s)
  Takahiro Yamanaka, Takashi Umehara, Natsumi Tsujita, Masayuki Shimada
- Organizer
  Society for the Study of Reproudction annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00361
[Presentation] マウスをモデルとした精巣の手術侵襲による機能低下機構の解析2023
- Author(s)
  佐藤亜美，山中貴寛，島田昌之
- Organizer
  日本生殖免疫学会
- Data Source
  KAKENHI-PROJECT-23H00361
[Presentation] TLR7/8刺激により排卵期卵巣が産生するIL5は炎症に伴う卵成熟の抑制を改善し、受精と胚発生を亢進する2023
- Author(s)
  岡本麻子，島田昌之
- Organizer
  日本生殖内分泌学会
- Data Source
  KAKENHI-PROJECT-23H00361
[Presentation] ミトコンドリア機能低下が引き起こす卵巣老化，その老化防止と根治法の開発2023
- Author(s)
  島田昌之
- Organizer
  日本抗加齢医学会
- Invited
- Data Source
  KAKENHI-PROJECT-23H00361
[Presentation] Sperm interaction with the uterine innate immune system: Toll-like receptor 2 (TLR2) is a main sensor in cattle.2022
- Author(s)
  Miyamoto A, Akthar I, Marey MA, Kim Y, Shimada M, Suarez SS.
- Organizer
  48th Annual Conference of International Embryo Technology Society (IETS), Savannah, Georgia USA.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03122
[Presentation] Sperm penetrate the uterine glands and induce uterine secretions that enhances other sperm hyperactivation and death.2022
- Author(s)
  6)Akthar I, Sumitani M, Aoki R, Shimada M, Miyamoto A.
- Organizer
  第115回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-20H03122
[Presentation] Roadmap to pregnancy in the first 7 days post-insemination in the cow: Immune cross-talk in the corpus luteum, oviduct and uterus.2022
- Author(s)
  2)Miyamoto A, Talukder AK, Marey MA, Shirasuna K, Kusama K, Shimada M, Imakawa K.
- Organizer
  19th International Congress on Animal Reproduction (ICAR)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03122
[Presentation] Sperm interaction with the uterine innate immune system: Toll-like receptor 2 (TLR2) is a main sensor in cattle.2022
- Author(s)
  1)Miyamoto A, Akthar I, Marey MA, Kim Y, Shimada M, Suarez SS.
- Organizer
  48th Annual Conference of International Embryo Technology Society (IETS)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03122
[Presentation] 前胞状卵胞における卵胞閉鎖酸化ストレスと抗酸化因子のバランス2021
- Author(s)
  島田昌之
- Organizer
  第39回日本受精着床学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] 種雄豚の生殖生理と繁殖技術2021
- Author(s)
  島田昌之
- Organizer
  第164回日本獣医学会学術集会獣医繁殖学分科会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] FSHが誘導するコルチゾール代謝亢進による卵胞選抜メカニズムの解明2021
- Author(s)
  中西寛弥, 岡本麻子, 島田昌之, 山下泰尚
- Organizer
  日本畜産学会第129回大会
- Data Source
  KAKENHI-PROJECT-19K06359
[Presentation] マウスを用いた基礎研究から，ブタの産子数向上技術へのトランスレーション2021
- Author(s)
  島田昌之
- Organizer
  第129回日本畜産学会第129回大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] Activation of sperm toll-like receptor 2 induces the mucus penetrating ability and subsequent sperm-induced uterine gland inflammatory responses in cattle.2021
- Author(s)
  Akthar I, Kim Y, Umehara T, Marey MA, Shimada M, Miyamoto A.
- Organizer
  第114回日本繁殖生物学会、2021.9.21-9.24、京都大
- Data Source
  KAKENHI-PROJECT-20H03122
[Presentation] 精子に発現するToll様受容体（TLR family）の役割と精子選別法2021
- Author(s)
  島田昌之
- Organizer
  第20回生殖バイオロジー東京シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] Sperm TLR2 regulates Ca2+ influx and acrosome reaction to facilitate sperm penetration to oocytes during in vitro fertilization in cows.2021
- Author(s)
  Ma D, Marey MA, Akthar I, Shimada M, Miyamoto A.
- Organizer
  第114回日本繁殖生物学会、2021.9.21-9.24、京都大
- Data Source
  KAKENHI-PROJECT-20H03122
[Presentation] 脂肪化精巣・脂肪化卵巣からわかる「老化」の新知見2021
- Author(s)
  島田昌之
- Organizer
  第21回日本抗加齢医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] 生殖生物学の新知見に基づく家畜繁殖技術開発2021
- Author(s)
  島田昌之
- Organizer
  第66回日本生殖医学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] 繁殖生物学の基礎研究から健康と福祉、食料生産への貢献2021
- Author(s)
  島田昌之
- Organizer
  日本学術会議，日本繁殖生物学会共催
- Invited
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] マウスにおける鉄欠乏は卵胞発育不全による雌性不妊を引き起こす2020
- Author(s)
  藤内慎梧，河端茜，島田昌之，山下泰尚
- Organizer
  第23回日本IVF学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06359
[Presentation] 生殖細胞におけるミトコンドリアと細胞質，核の情報交換2020
- Author(s)
  島田昌之
- Organizer
  日本受精着床学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] 哺乳類の雌雄比が1:1となる仕組み2020
- Author(s)
  島田昌之
- Organizer
  日本繁殖生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] NeurotensinはERK1/2系の持続的リン酸化を促進し排卵を誘起する2020
- Author(s)
  岡本麻子，島田昌之，山下泰尚
- Organizer
  第23回日本IVF学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06359
[Presentation] 顆粒膜細胞で発現上昇するSREBPは，排卵期のプロゲステロン産生に必須である2020
- Author(s)
  中西寛弥，田中里沙，島田昌之，山下泰尚
- Organizer
  第23回日本IVF学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06359
[Presentation] 精子，卵，受精卵の代謝機構とその人為的制御，ARTへの応用2020
- Author(s)
  島田昌之
- Organizer
  日本IVF学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] より多く、より良い成熟卵を得るための対ミトコンドリア戦略2019
- Author(s)
  島田昌之
- Organizer
  日本受精着床学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] 比較生殖生物学，精子の動物種間差～基礎研究を日々の臨床につなげるために～2019
- Author(s)
  島田昌之
- Organizer
  第２４回日本臨床エンブリオロジスト学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19324
[Presentation] The pretreatment with collagenase before vitrification improves the ovarian reserve due to the maintenance of the cell-cell attachments with oocyte and granulosa cells2019
- Author(s)
  Tomoko Kawai and Masayuki Shimada
- Organizer
  35th Eshre annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] 卵胞発育と酸化ストレス2019
- Author(s)
  島田昌之
- Organizer
  生殖バイオロジー東京シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] 排卵前卵胞の顆粒膜細胞における大規模なゲノム構造の変化は、顆粒膜細胞の分化に重要である2019
- Author(s)
  川合智子, S.A Masudul Hoque, JoAne S. Richards 島田昌之
- Organizer
  日本生殖内分泌学会
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] Dramatic epigenetic changes in the genome impact gene expression and the differentiation of ovarian granulosa cells2019
- Author(s)
  Tomoko Kawai, S.A Masudul Hoque, JoAne S. Richards and Masayuki Shimada
- Organizer
  Society for the Study of Reproduction
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03108
[Presentation] The aging ovary: restriction of follicle growth by abnormal endocrine functions and ovarian stromal matrix fibrosis2018
- Author(s)
  Masayuki Shimada
- Organizer
  15th International Symposium of Immunology of Reproduction
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] 精液成分が決定する精子の直進運動性～その持続時間に関するミトコンドリア内セントラルドグマと酸化ストレスとの関係～2018
- Author(s)
  島田昌之
- Organizer
  第18回日本Men’s Health医学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19324
[Presentation] シンポジウム「エピジェネティックスと生殖」卵胞発育過程における大規模なDNA脱メチル化による排卵準備2018
- Author(s)
  島田昌之
- Organizer
  第36回日本受精着床学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] シンポジウム２「「家畜繁殖技術の温故知新　ブレークスルーのために」」ブタ人工授精技術のイノベーション2018
- Author(s)
  島田昌之
- Organizer
  第111回日本繁殖生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] シンポジウム「IVMの新展開」卵胞発育ステージに合わせたIVM2018
- Author(s)
  島田昌之
- Organizer
  第36回日本受精着床学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] シンポジウム「加齢と妊孕能」加齢に伴う卵巣機能低下の原因探索2018
- Author(s)
  島田昌之
- Organizer
  第36回日本受精着床学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] シンポジウム27　「ホルモンと生殖」　Neuregulin1による雌雄配偶子形成メカニズム2018
- Author(s)
  島田昌之
- Organizer
  第91回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] ランチョンセミナー6　成熟卵・良好胚を獲得するために～基礎・臨床から考える～2018
- Author(s)
  島田昌之
- Organizer
  第63回日本生殖医学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] ブタ人工授精技術のイノベーション2018
- Author(s)
  島田昌之
- Organizer
  第111回日本繁殖生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19324
[Presentation] 加齢に伴う卵胞発育不全（ローレスポンダー）の原因探索とその治療戦略2017
- Author(s)
  島田昌之
- Organizer
  内分泌代謝アップデート
- Invited
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] 高FSH/高LHがもたらす卵巣皮質の繊維化による2次卵胞発育不全～Nrg1KOマウスをモデルとした卵巣加齢化研究～2017
- Author(s)
  島田昌之
- Organizer
  日本生殖医学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] 卵巣の老化と卵成熟障害2017
- Author(s)
  島田昌之
- Organizer
  日本受精着床学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] CYP26b1-induced degradation of retinoic acid is essential for the differentiation of trophoblast cells2017
- Author(s)
  Tomoko Kawai, Yumi Hoshino and Masayuki Shimada
- Organizer
  Annual meeting of Society for the Study of Reproduction
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] 排卵過程で産生されるfibronectinの卵成熟に果たす役割2017
- Author(s)
  北坂，川合智子，梅原崇，島田昌之
- Organizer
  日本卵子学会
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] 多嚢胞性卵巣症候群における内分泌破綻，マウスモデルを用いた原因と卵胞発達・排卵への影響探索2017
- Author(s)
  島田昌之
- Organizer
  日本産婦人科学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] Creatine enhances sperm capacitation and is associated with successful in vivo and in vitro fertilization in mice2017
- Author(s)
  Takashi Umehara, Satoshi Okuda, Tomoko Kawai, JoAnne S. Richards, Masayuki Shimada
- Organizer
  Annual meeting of Society for the Study of Reproduction
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] 内分泌・代謝学的アプローチから畜産の生産性アップへ，それに貢献する繁殖技術開発2017
- Author(s)
  島田昌之
- Organizer
  2017年度生命科学系学会（分子生物学会，生化学会）合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19324
[Presentation] 精液中微量成分分析とバイオマーカーとしての有用性について2017
- Author(s)
  陸彦、瀧本陽介、島田昌之、堀江重郎
- Organizer
  メンズヘルス医学会
- Data Source
  KAKENHI-PROJECT-17K19324
[Presentation] Embryo induces immune tolerance in bovine oviduct and uterus in vitro.2017
- Author(s)
  Talukder AK, Yousef MS, Rashid MB, 粟井健介, 清水隆, 島田昌之, 今川和彦, 宮本明夫
- Organizer
  日本畜産学会第１２２回大会
- Place of Presentation
  神戸大学（兵庫県・神戸市）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16H05013
[Presentation] 卵丘細胞で発現するNeurotensinのEGFR活性維持を介した卵成熟調節機能2016
- Author(s)
  岡本麻子、島田昌之、山下泰尚
- Organizer
  第20回日本生殖内分泌学会学術集会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2016-01-09
- Data Source
  KAKENHI-PROJECT-26450381
[Presentation] 採卵時に未成熟であった卵を如何に臨床に用いるか？2016
- Author(s)
  島田昌之
- Organizer
  日本生殖再生医学会学術集会
- Place of Presentation
  東京都
- Year and Date
  2016-03-04
- Invited
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] Cell type-specific demethylation of LH Receptor (Lhcgr) promoter regions facilitates FSH mediated induction of Lhcgr in murine granulosa cells of preovulatory follicles.2016
- Author(s)
  Kawai T, Richards JS and Shimada M
- Organizer
  49th Annual Meeting of Society for the Study of Reproduction, USA
- Place of Presentation
  サンディエゴ，USA
- Year and Date
  2016-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] 精子の免疫能と耐凍能2016
- Author(s)
  島田昌之
- Organizer
  日本がん生殖学会
- Place of Presentation
  東京都
- Year and Date
  2016-02-07
- Invited
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] 排卵時の顆粒膜細胞で発現するNeurotensinはADAM17活性を亢進し、卵丘細胞のEGF受容体-ERK1/2系の持続的活性化を誘導する2016
- Author(s)
  岡本麻子、島田昌之、山下泰尚
- Organizer
  第57回日本卵子学会
- Place of Presentation
  朱鷺メッセ（新潟市）
- Year and Date
  2016-05-14
- Data Source
  KAKENHI-PROJECT-26450381
[Presentation] 採卵された（てしまった）未成熟卵を如何に培養するか？2016
- Author(s)
  島田昌之
- Organizer
  日本受精着床学会
- Place of Presentation
  軽井沢
- Year and Date
  2016-09-20
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] Transferrin(TF)-Fe3+により誘導されるブタ卵の減数分裂裁可抑制とその卵の発生に及ぼす影響2016
- Author(s)
  河端茜、堺優俊、清亜咲美、島田昌之、山下泰尚
- Organizer
  第121回日本畜産学会学術集会
- Place of Presentation
  日本獣医生命科学大学
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26450381
[Presentation] プロゲステロン代謝酵素依存的に蓄積するコルチゾールとその卵胞退行への影響2016
- Author(s)
  岡本麻子、金子亜絵理、池田真規、島田昌之、山下泰尚
- Organizer
  第121回日本畜産学会学術集会
- Place of Presentation
  日本獣医生命科学大学
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26450381
[Presentation] LH-induced NRG1 is essential for adult Leydig cell proliferation in the infant testis that determines androgen production and spermatogenesis in adult male mice.2016
- Author(s)
  Umehara T, Zeng WX, Richards JS and Shimada M
- Organizer
  49th Annual Meeting of Society for the Study of Reproduction, USA
- Place of Presentation
  サンディエゴ，USA
- Year and Date
  2016-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05017
[Presentation] 加齢に伴う卵巣機能低下が及ぼす卵成熟への影響2015
- Author(s)
  島田昌之
- Organizer
  日本受精着床学会学術集会
- Place of Presentation
  東京都
- Year and Date
  2015-11-20
- Invited
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] 顆粒膜細胞が分泌する局所因子による卵丘細胞の機能的変化と卵成熟制御2015
- Author(s)
  島田昌之
- Organizer
  日本生殖医学会総会
- Place of Presentation
  横浜
- Year and Date
  2015-04-17
- Invited
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] 顆粒膜細胞のCYP11B1発現依存的コルチゾール産生が引き起こす卵胞退行メカニズム2015
- Author(s)
  岡本麻子、池田真規、島田昌之、山下泰尚
- Organizer
  第56回日本卵子学会学術集会
- Place of Presentation
  栃木県総合文化センター
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-26450381
[Presentation] Transferrin-Fe3+は顆粒層細胞と卵丘細胞の機能性を亢進し、卵胞発育を誘導する2015
- Author(s)
  河端茜、内橋しづき、島田昌之、山下泰尚
- Organizer
  第108回日本繁殖生物学会学術集会
- Place of Presentation
  宮崎大学
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-26450381
[Presentation] 受精に関わる免疫機能の解明とそれを利用した繁殖技術の開発2015
- Author(s)
  島田昌之
- Organizer
  日本生殖工学会学術集会
- Place of Presentation
  東京都
- Year and Date
  2015-12-13
- Invited
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] プロゲステロン代謝抑制が誘導するブタ卵胞部選抜メカニズム2015
- Author(s)
  岡本麻子、金子亜絵理、池田真規、島田昌之、山下泰尚
- Organizer
  第108回日本繁殖生物学会学術集会
- Place of Presentation
  宮崎大学
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-26450381
[Presentation] The dramatic changes cumulus cell functions during ovulation process impact meiotic progression and fertilization ability of oocyte2015
- Author(s)
  Shimada M
- Organizer
  14th International Symposium of Immunology of Reproduction,
- Place of Presentation
  Varna, Bulgaria
- Year and Date
  2015-06-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] The innate immune functions of male and female germ cells2015
- Author(s)
  島田昌之
- Organizer
  日本繁殖生物学会学術集会
- Place of Presentation
  宮崎
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] Cumulus cells are essential mediators of LH induced ovulation stimuli from granulosa cells to the oocyte.2014
- Author(s)
  Shimada M.
- Organizer
  3ed World Congress of Reproductive Biology,
- Invited
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] 1.遺伝子改変（欠損）マウスの解析から体外成熟培養，体外受精系を考える2014
- Author(s)
  島田昌之
- Organizer
  日本卵子学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] The role of cumulus cells in meiotic resumption and oocyte maturation2013
- Author(s)
  島田昌之
- Organizer
  International Ovarina Conference, 2013
- Place of Presentation
  Taipei・Taiwan(招待講演)
- Year and Date
  2013-03-10
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] Cumulus cells are an essential mediator of ovulation stimuli from granulosa cells to oocyte2012
- Author(s)
  Shimada M
- Organizer
  International Ovarian Conference
- Place of Presentation
  東京都(シンポジウム)(招待講演)
- Year and Date
  2012-03-17
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 成熟卵のクオリティーと卵丘細胞の機能変化2012
- Author(s)
  島田昌之
- Organizer
  日本受精着床学会
- Place of Presentation
  大阪市(招待講演)
- Year and Date
  2012-08-30
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] Cumulus cells are an essential mediator of ovulation stimuli from granulosa cells to oocyte, International Ovarian Conference2012
- Author(s)
  M. Shimada
- Organizer
  東京都
- Place of Presentation
  東京都
- Year and Date
  2012-03-17
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 卵胞環境の時期特異的変化を考慮した体外成熟培養2011
- Author(s)
  島田昌之
- Organizer
  日本受精着床学会
- Place of Presentation
  東京都(招待講演)
- Year and Date
  2011-09-07
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] EGF like factorによる卵成熟,排卵調節機構2011
- Author(s)
  島田昌之
- Organizer
  日本内分泌学会
- Place of Presentation
  神戸市(招待講演)
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 卵胞発育,排卵期におけるか流膜細胞のシグナル伝達経路の役割2011
- Author(s)
  島田昌之
- Organizer
  第51回日本哺乳動物卵子学会
- Place of Presentation
  大田原市
- Year and Date
  2011-05-22
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 卵胞環境の時期特異的変化を考慮した体外成熟培養2011
- Author(s)
  島田昌之
- Organizer
  第29回日本受精着床学会,東京都
- Place of Presentation
  東京都
- Year and Date
  2011-09-07
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] EGF like factorによる卵成熟,排卵調節機構2011
- Author(s)
  島田昌之
- Organizer
  第84回日本内分泌学会,神戸市
- Place of Presentation
  神戸市
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] Cumulus cell-oocyte complex expansion is regulated by Ca2+ induced m-calpain activity leading to cumulus cell motility and migration2011
- Author(s)
  I. Kawashima, Z. Liu, L. K. Mullany, J. S. Richards, M. Shimada
- Organizer
  44th Annual Meeting of Society for the Study of Reproduction
- Place of Presentation
  Portland, Oregon, USA
- Year and Date
  2011-08-05
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] Cumulus cells play an important role to induce meiotic resumption and progression of oocyte2011
- Author(s)
  Shimada M
- Organizer
  日本繁殖生物学会JSPS Japan-Poland Joint Seminar Cutting-edge Reproductive Physiology
- Place of Presentation
  盛岡市(招待講演)
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 卵胞発育,排卵期における顆粒膜細胞のシグナル伝達経路の役割2011
- Author(s)
  島田昌之
- Organizer
  日本哺乳動物卵子学会
- Place of Presentation
  栃木県大田原市(招待講演)
- Year and Date
  2011-05-22
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 卵胞発育と卵成熟2011
- Author(s)
  島田昌之
- Organizer
  生殖バイオロジー東京シンポジウム
- Place of Presentation
  東京都(招待講演)
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] The expression of acetaldehyde dehydrogenase (ALDH) type I family is required for the decrease of endogenous acetaldehyde toxicity during ovarian follicular development in mouse and human2011
- Author(s)
  Shimada M
- Organizer
  北米繁殖生物学会(Society for the Study of Reproduction)
- Place of Presentation
  Portland(米国)
- Year and Date
  2011-08-05
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 排卵刺激は,卵子成熟のみでなく受精能,着床誘導をも司るエッセンシャルファクターである2011
- Author(s)
  島田昌之
- Organizer
  東京受精・胚培養研究会
- Place of Presentation
  東京都(招待講演)
- Year and Date
  2011-07-10
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 卵子の受精後の発生能を高める仕組みの解明とそのIVMへの応用2010
- Author(s)
  島田昌子
- Organizer
  第5回日本生殖再生医学会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 凍結精液の作製とその利用法を考える-「きちんと凍結する」,「上手に融かす」,「最適条件で受(授)精させる」-2010
- Author(s)
  島田昌之
- Organizer
  日本受精着床学会
- Place of Presentation
  横浜市(招請講演)
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PUBLICLY-21028014
[Presentation] Cumulus cells are an essential mediator of ovulation stimuli from granulosa cells to oocyte2010
- Author(s)
  島田昌之
- Organizer
  日本繁殖生物学会
- Place of Presentation
  十和田市(招待講演)
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 卵子の受精後の発生能を高める仕組みの解明とそのIVMへの応用2010
- Author(s)
  島田昌之
- Organizer
  第5回日本生殖再生医学会
- Place of Presentation
  東京都
- Year and Date
  2010-02-21
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] The innate immunefunctions of male and female germcells-The expression of TLR familyreduces the risk of infection problemfrom fetus2010
- Author(s)
  M. Shimada
- Organizer
  30^<th> Annual meeting of The American Society for ReproductiveImmunology
- Place of Presentation
  Pennsylvania ，USA
- Year and Date
  2010-05-17
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] Cumulus cells are an essential mediator of ovulation stimuli from granulosa cells to oocyte2010
- Author(s)
  島田昌之
- Organizer
  日本繁殖生物学会
- Place of Presentation
  十和田市(招請講演)
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PUBLICLY-21028014
[Presentation] Cumulus cells are anessential mediator of ovulationstimuli from granulosa cells to oocyte2010
- Author(s)
  島田昌之
- Organizer
  第103回日本繁殖生物学会
- Place of Presentation
  十和田市
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 卵子成熟を制御する顆粒膜細胞分泌因子2010
- Author(s)
  島田昌之
- Organizer
  日本生殖内分泌学会
- Place of Presentation
  大阪府吹田市(招請講演)
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PUBLICLY-21028014
[Presentation] 卵子の受精後の発生能を高める仕組みの解明とそのIVMへの応用2010
- Author(s)
  島田昌之
- Organizer
  第5回日本生殖再生医学会シナポジウム
- Place of Presentation
  東京
- Year and Date
  2010-02-25
- Data Source
  KAKENHI-PUBLICLY-21028014
[Presentation] 卵子成熟を制御する顆粒膜細胞分泌因子2010
- Author(s)
  島田昌之
- Organizer
  日本生殖内分泌学会
- Place of Presentation
  大阪府吹田市(招待講演)
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 顆粒膜細胞に発現するALDH1familyが,産生されるアセトアルデヒドを分解し,排卵前卵胞への発育を促進する2010
- Author(s)
  川合智子, 川島一公, Zhilin Liu, 藤田陽子, 根岸広明, JoAnne S. Richards, 島田昌之
- Organizer
  第50回日本哺乳動物卵子学会
- Place of Presentation
  新潟市
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 卵胞発育,排卵過程の顆粒膜細胞におけるToll-likereceptor familyの発現とその機能解析2010
- Author(s)
  畑慧, 川合智子, 下中麻奈美, 島田昌之, hilin Liu, JoAnne S. Richards, 渡辺浩彦, 森崇英
- Organizer
  第55回日本生殖医学会,徳島市
- Place of Presentation
  徳島市
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] The innate immune functions of male and female germ cells-The expression of TLR family reduces the risk of infection problem from fetus2010
- Author(s)
  島田昌之
- Organizer
  30^<th> annual meeting of American society of reproductive immunology
- Place of Presentation
  ピッツバーグ,アメリカ合衆国(招請講演)
- Year and Date
  2010-05-17
- Data Source
  KAKENHI-PUBLICLY-21028014
[Presentation] The innate immune functions of male and female germ cells -The expression of TLR family reduces the risk of infection problem from fetus2010
- Author(s)
  島田昌之
- Organizer
  30^<th> annual meeting of American society of reproductive immunology
- Place of Presentation
  ピッツバーグ,アメリカ合衆国(招待講演)
- Year and Date
  2010-05-17
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 卵子成熟を制御する顆粒膜細胞分泌因子2010
- Author(s)
  島田昌之
- Organizer
  第15回日本生殖内分泌学会第15回日本生殖内分泌学会
- Place of Presentation
  吹田市
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 凍結精液の作製とその利用法を考える-「きちんと凍結する」,「上手に融かす」,「最適条件で受(授)精させる」-2010
- Author(s)
  島田昌之
- Organizer
  日本受精着床学会
- Place of Presentation
  横浜市(招待講演)
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] ブタ成熟卵子の発生能向上に果たすNeuregulin 1 の役割2009
- Author(s)
  川島一公・田畑慧・野間紀孝・岡崎哲司・島田昌之
- Organizer
  第110回日本畜産学会大会
- Place of Presentation
  藤沢
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] Neuregulin 1 is a novel oocyte maturation regulatory factor expressed in granulosa cells during ovulation process in mice2009
- Author(s)
  Shimada M
- Organizer
  42^<th> Annual Meeting of Society for the Study of Reproduction, oral presentation
- Place of Presentation
  Pittsburgh, USA
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PUBLICLY-21028014
[Presentation] The involvement of Toll-like receptor family expressed oncumulus cells in fertilization2009
- Author(s)
  M. Shimada
- Organizer
  12^<th> International symposium of Immunology of Reproduction
- Place of Presentation
  Verna, Bulgaria
- Year and Date
  2009-06-18
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 排卵刺激による卵胞環境の段階的誘導(sequential induction)が卵子成熟を制御する2009
- Author(s)
  島田昌子
- Organizer
  第27回日本受精着床学会教育講演
- Place of Presentation
  京都
- Year and Date
  2009-08-05
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] The involvement of Toll-like receptor family expressed on cumulus cells in fertilization2009
- Author(s)
  Shimada M
- Organizer
  12^<th> International symposium of Immunology of Reproduction, invited speaker
- Place of Presentation
  Bulgaria, Varna
- Year and Date
  2009-06-18
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 排卵刺激による卵胞環境の段階的誘導(sequential induction)が卵子成熟を制御する2009
- Author(s)
  島田昌之
- Organizer
  第27回日本受精着床学会教育講演
- Place of Presentation
  京都
- Year and Date
  2009-08-05
- Data Source
  KAKENHI-PUBLICLY-21028014
[Presentation] Neuregulin 1 is a novel oocyte maturation regulatory factor expressed in granulosa cells during ovulation process in mice2009
- Author(s)
  Shimada M
- Organizer
  42^<th> Annual Meeting of Society for the Study of Reproduction,oral presentation
- Place of Presentation
  USA、Pittsburgh Pennsylvania
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 顆粒膜細胞で発現するNeuregulin-1(NRG1)は, Sphingosine-1-Phosphate(S1P)の産生を介して卵子の減数分裂進行速度を調整し,発生能を獲得させる2009
- Author(s)
  川島一公, 野間紀孝, 島田昌之
- Organizer
  第14回日本生殖内分泌学会大会
- Place of Presentation
  東京都
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] 顆粒膜細胞特異的ERK1/2 遺伝子欠損マウスを用いたLH サージによる卵胞内エストロジェン濃度低下が誘起する排卵機構の解析2009
- Author(s)
  田畑慧・Fan HY・Richards JS.・下中麻奈美・野々口耕介・渡辺浩彦・森崇英・島田昌之
- Organizer
  第50回日本哺乳動物卵子学会大会
- Place of Presentation
  東京
- Year and Date
  2009-05-08
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] ERK1/2 系が顆粒層細胞の排卵期特異的な遺伝子発現を誘起する2009
- Author(s)
  下中麻奈美, 田畑慧, Fan HY, Richards JS, 島田昌之
- Organizer
  第4回日本生殖再生医学会
- Place of Presentation
  東京
- Year and Date
  2009-03-15
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] 排卵刺激による卵胞環境の段階的誘導(sequential induction)が卵子成熟を制御する2009
- Author(s)
  島田昌之
- Organizer
  第27回日本受精着床学会総会・学術集会,教育講演
- Place of Presentation
  京都市
- Year and Date
  2009-08-05
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] Neuregulin 1 is a novel oocyte maturation regulatory factor expressed in granulosa cells during ovulation process in mice2009
- Author(s)
  M. Shimada, N. Noma, M. Shitanaka, I. Kawashima, H. Y. Fan, J. S. Richards
- Organizer
  42^<th> Annual Meeting of Society for the Study of Reproduction
- Place of Presentation
  Pittsburg, USA
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-21688019
[Presentation] The involvement of Toll-like receptor family expressed on cumulus cells in fertilization2009
- Author(s)
  Shimada M
- Organizer
  12^<th> International symposium of Immunology of Reproduction, invited speaker
- Place of Presentation
  Varna, Bulgaria
- Year and Date
  2009-06-18
- Data Source
  KAKENHI-PUBLICLY-21028014
[Presentation] Expression of synaptotagniin 1 (Syt1) is induced and facilitatcs secretion vubicle binding to the granulosa/cumulus cell plasma membrane protein SNAP 25 during ovulation in the mouse2008
- Author(s)
  M. Shimada
- Organizer
  The Endocrine Society
- Place of Presentation
  San Francisco, USA
- Year and Date
  2008-06-04
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] 卵丘細胞に発現するToll-like receptor(TLR)によるケモカイン分泌磯構の基礎的解明とヒト体外受精不成功症例におけるケモカイン類の網羅的解析2008
- Author(s)
  島田昌之
- Organizer
  日本受精着床学会
- Place of Presentation
  福岡市
- Year and Date
  2008-08-24
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] Sequential exposure of porcine cumulus cells to FSH and LH is critical for appropriate expression of steroidogenic and ovulation related genes that impact oocyte maturation in vivo and in vitro2008
- Author(s)
  M. Shimada
- Organizer
  The Society for the Study of Reproduction
- Place of Presentation
  Kona, USA
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] LSL/KrasG12/D ; Cyp19Cre マウスを用いたEGF like family が誘起する卵子成熟機構の解析2008
- Author(s)
  野間紀孝・Fan HY・Richards JS・島田昌之
- Organizer
  第49回日本哺乳動物卵子学会大会
- Place of Presentation
  名古屋
- Year and Date
  2008-05-13
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] 排卵過程の顆粒層細胞におけるAmphiregulin (AREG)発現制御機構の解析2008
- Author(s)
  下中麻奈美,Richards JS,島田昌之
- Organizer
  第13回日本生殖内分泌学会大会
- Place of Presentation
  大阪
- Year and Date
  2008-11-30
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] Sequential exposure of porcine cumulus cells to FSH and LH is critical for appropriate expression of steroidogenic and ovulation related genes that impact oocyte maturation in vivo2008
- Author(s)
  Shimada M, Kawashima I, Okazaki T, Yamashita Y
- Organizer
  in vitro 41th Annual Meeting of Society for the Study of Reproduction
- Place of Presentation
  Cona,Hawai,USA
- Year and Date
  2008-05-25
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] 排卵過程の顆粒層細胞におけるSNAP25により制御されるホルモン分泌機構2007
- Author(s)
  島田昌之
- Organizer
  日本生殖内分泌学会
- Place of Presentation
  東京都
- Year and Date
  2007-10-29
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] 受精過程に分解されるヒアルロン酸は,卵丘細胞のToll-like receptorを介してケモカインを分泌させ,精子の受精能獲得を誘起させる2007
- Author(s)
  島田昌之
- Organizer
  日本受精着床学会
- Place of Presentation
  仙台市
- Year and Date
  2007-08-29
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] Activation of Toll-like receptors 2 and 4 on cumulus cells of ovulated cumulus oocyte complexes stimulates production of cytokines/chemokines that can induce sperm capacitation leading to successful fertilization2007
- Author(s)
  Shimada M, Yanai Y, Okazaki T, Richards JS
- Organizer
  40th Annual Meeting of Society for the Study of Reproduction
- Place of Presentation
  San Antonio, USA
- Year and Date
  2007-07-26
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] 受精過程に分解されるヒアルロン酸は,卵丘細胞のToll-like receptor を介してケモカインを分泌させ,精子の受精能獲得を誘起させる2007
- Author(s)
  島田昌之,柳内嘉在,岡崎哲司, Richards JS
- Organizer
  第25回日本受精着床学会
- Place of Presentation
  仙台
- Year and Date
  2007-08-30
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] Activation of Toll-like receptors 2 and 4 on cumulus cells of ovulated cumulus oocyte complexes stimulates production of cytokines/cliemokines that can induce sperm capacitation leading to successful fertilization2007
- Author(s)
  M. Shimada
- Organizer
  The Society for the Study of Reproduction
- Place of Presentation
  San Antonio, USA
- Year and Date
  2007-07-20
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] Expression of the murine synaptosome-associated protein 25 (Snap25) gene is required for cytokine exocvtosis from granulosa cells2007
- Author(s)
  M. Shimada
- Organizer
  The Endocrine Society
- Place of Presentation
  Toronto, Canada
- Year and Date
  2007-06-02
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] 排卵過程の顆粒層細胞におけるSNAP25 により制御されるホルモン分泌機構2007
- Author(s)
  島田昌之,柳内嘉在,西松恵子,Richards JS,西堀正英
- Organizer
  第12回日本生殖内分泌学会大会
- Place of Presentation
  東京
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] During ovulation pattern recognition receptors (PRRs) characteristic of immune cells are induced in cumulus oocyte complexes (COCs) to confer immune cell-like functions2006
- Author(s)
  Shimada M, Hernandez-Gonzalez I, Gonzalez-Robanya I, Richards JS
- Organizer
  39th Annual Meeting of Society for the Study of Reproduction
- Place of Presentation
  Omaha,USA
- Year and Date
  2006-07-31
- Data Source
  KAKENHI-PROJECT-18688016
[Presentation] 健常卵胞のステロイドホルモン環境が退行卵胞由来COCのアポトーシスに及ぼす影響
- Author(s)
  池田真規、清亜咲美、門川真諭、島田昌之、山下泰尚
- Organizer
  第107回日本繁殖生物学会
- Place of Presentation
  帯広畜産大学
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-26450381
[Presentation] 排卵期の卵丘細胞で活性化するCalpain 2－その活性化機構と排卵，卵成熟への役割－
- Author(s)
  島田昌之
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PUBLICLY-25132708
[Presentation] ブタ卵胞発育時のプロゲステロン代謝酵素・AKR1C1の発現と役割
- Author(s)
  岡本麻子、門川真諭、池田真規、島田昌之、山下泰尚
- Organizer
  第119回日本畜産学会
- Place of Presentation
  宇都宮大学
- Year and Date
  2015-03-27 – 2015-03-30
- Data Source
  KAKENHI-PROJECT-26450381
[Presentation] 卵丘細胞におけるNeurotensinのEGF受容体発現上昇作用とそれが卵丘細胞膨潤と卵成熟に果たす役割
- Author(s)
  岡本麻子、成田恵菜、河端茜、島田昌之、山下泰尚
- Organizer
  第107回日本繁殖生物学会
- Place of Presentation
  帯広畜産大学
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-26450381
[Presentation] 1.遺伝子改変（欠損）マウスの解析から体外成熟培養，体外受精系を考える
- Author(s)
  島田昌之
- Organizer
  日本卵子学会学術集会
- Place of Presentation
  神戸市
- Year and Date
  2014-05-17 – 2014-05-18
- Invited
- Data Source
  KAKENHI-PUBLICLY-25132708
[Presentation] マウスモデルにおける雌個体の加齢による卵巣機能の低下－解毒作用の低下の可能性－
- Author(s)
  島田昌之
- Organizer
  日本IVF学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PUBLICLY-25132708
[Presentation] Cumulus cells are essential mediators of LH induced ovulation stimuli from granulosa cells to the oocyte.
- Author(s)
  Shimada M
- Organizer
  3ed World Congress of Reproductive Biology,
- Place of Presentation
  Edinburg, Scotland
- Year and Date
  2014-09-02 – 2014-09-04
- Invited
- Data Source
  KAKENHI-PUBLICLY-25132708
[Presentation] The immune cell-like functions of cumulus cells during ovulation and fertilization process
- Author(s)
  Masayuki Shimada
- Organizer
  International Congress of Reproductive Immunology
- Place of Presentation
  Boston, USA
- Invited
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] ブタ卵丘細胞卵複合体(COC)の体外培養時におけるNeurotensin(NTS)の発現とその役割
- Author(s)
  永村優、岡本麻子、島田昌之、山下泰尚
- Organizer
  第107回日本繁殖生物学会
- Place of Presentation
  帯広畜産大学
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-26450381
[Presentation] Neurotensinは、排卵時にヒアルロン酸産生を促し、卵丘細胞の膨潤を促進する
- Author(s)
  岡本麻子、島田昌之、山下泰尚
- Organizer
  第55回日本卵子学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2014-05-17 – 2014-05-18
- Data Source
  KAKENHI-PROJECT-26450381
[Presentation] 新たな顆粒膜細胞の分泌因子NRG1の卵成熟に果たす役割
- Author(s)
  島田昌之
- Organizer
  日本内分泌学会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] The immune cell-like functions of cumulus cells impact ovulation and the fertilization process
- Author(s)
  Masayuki Shimada
- Organizer
  International Congress of Reproductive Immunology
- Place of Presentation
  Boston, USA
- Invited
- Data Source
  KAKENHI-PUBLICLY-25132708
[Presentation] Targeted disruption of neuregulin 1 in granulosa cells reveals an important role in oocyte maturation in vivo
- Author(s)
  Masayuki Shimada
- Organizer
  Annual Meeting of Society for the Study of Reproduction
- Place of Presentation
  Montriol, Canada
- Data Source
  KAKENHI-PUBLICLY-25132708
[Presentation] 新たな顆粒膜細胞の分泌因子NRG1の卵成熟に果たす役割
- Author(s)
  島田昌之
- Organizer
  日本内分泌学会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PUBLICLY-25132708
[Presentation] Targeted disruption of neuregulin 1 in granulosa cells reveals an important role in oocyte maturation in vivo
- Author(s)
  Masayuki Shimada
- Organizer
  Annual Meeting of Society for the Study of Reproduction
- Place of Presentation
  Montriol, Canada
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] 排卵期の卵丘細胞で活性化するCalpain 2－その活性化機構と排卵，卵成熟への役割－
- Author(s)
  島田昌之
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] 二つの意味の卵の老化と卵巣の老化
- Author(s)
  島田昌之
- Organizer
  日本抗加齢医学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24688028
[Presentation] 二つの意味の卵の老化と卵巣の老化
- Author(s)
  島田昌之
- Organizer
  日本抗加齢医学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PUBLICLY-25132708

1. Miyamoto Akio (10192767)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
2. 今川和彦 (00291956)

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3. Yamashita Yasuhisa (50452545)

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6. ISOBE Naoki (80284230)

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7. SATO Eimei (80093243)

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8. TERADA Takato (60034477)

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10. SAKAI Youichi (70309946)

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11. YAMASHITA Ichiro (20144884)

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13. TAKASE Minoru (80226779)

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14. 藤田正範 (20124802)

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15. 中川平介 (00034471)

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18. 堀正敏 (70211547)

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19. 梅原崇 (60826858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
20. 杉野利久 (90363035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. Richards JoAnne S.

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
22. ELHAMOULY MOUSTAFA

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 川島一公

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 藤森俊彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 岡本麻子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 川合智子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimada Masayuki 島田 昌之

SHIMADA Masayuki 島田 昌之

島田 昌幸 シマダ マサユキ

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Study of the Mechanism of Ovarian Maturation Focusing on Gradual Cellular Composition Changes in the StromPrincipal Investigator

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The mechanisms of chronic inflammation in ovarian stromaPrincipal Investigator

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The study for understanding the mechanisms how MSCs induce ovarian agingPrincipal Investigator

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The development of prevention and treatemnt methods of fertilization failure from mice modelPrincipal Investigator

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The epigenetic regulation of follicular development by the expression of non-coding RNAPrincipal Investigator

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卵巣および精巣局所因子の発現，機能解析による配偶子形成機構の解明Principal Investigator

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The molecular endocrinology analysis of early fertility decline mouse to develop the novel breeding marker of livestock animalsPrincipal Investigator

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卵丘細胞のERKとPKB系に着目した哺乳動物卵子減数分裂再開制御因子の探索Principal Investigator

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Shimada Masayuki 島田昌之

SHIMADA Masayuki 島田昌之

島田昌幸シマダマサユキ