Hirawa Nobuhito 平和伸仁

… Alternative Names

HIRAWA Nobuhito 平和伸仁

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Researcher Number	20315766
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 附属市民総合医療センター, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 横浜市立大学, 附属市民総合医療センター, 准教授 2015: 横浜市立大学, 付属市民総合医療センター, 准教授 2014 – 2015: 横浜市立大学, 大学病院, 准教授 2013 – 2015: 横浜市立大学, 市民総合医療センター, 准教授 2013: 横浜市立大学, 附属市民総合医療センター, 准教授 … More 2009 – 2010: 横浜市立大学, 市民総合医療センター, 准教授 2008: 横浜市立大学, 附属市民総合医療センター・血液浄化室, 准教授 2004: 横浜市立大学, 医学部附属病院, 助教授 2004: Yokohama City University, YCU Medical Center, Associate Professor, 附属市民総合医療センター, 准教授 2001 – 2003: 横浜市立大学, 医学部, 助手 2000: 横浜市立大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Kidney internal medicine / Kidney internal medicine / Basic Section 53040:Nephrology-related Except Principal Investigator Kidney internal medicine / Basic Section 53020:Cardiology-related / Cardiovascular medicine
Keywords	Principal Investigator 高血圧 / ATP2B1 / カルシウム / Ca代謝 / SNPs / D / ACE I / KLK-1 / 一酸化窒素 / トランスジェニック … More / ノックアウト / 尿細管 / カリクレイン / 腎臓 / 血圧 / カルシウム代謝 / 利尿 / 水代謝 / 遺伝子 / 血管収縮 / 降圧メカニズム / Ca拮抗薬 / 副甲状腺ホルモン / カルシウムチャネル / hemodialysis / disequilibrium / prognosis / chronic kidney disease / kallikrein / SNP / 予後予測因子 / 慢性腎不全 / 血液透析 / 連鎖 / 生命予後 / 遺伝子変異 / 腎不全 / eNOS / カルシウム利尿 / 細胞内カルシウム / PMCA1 / 血管平滑筋 / knock out / mice / GWAS / nitric oxide / hypertension / ACE多型 / 臓器障害 / 遺伝子多型 / 本態性高血圧 … More Except Principal Investigator 本態性高血圧 / LPIN1遺伝子 / ATP2B1遺伝子 / ノックアウトマウス / fldマウス / ゲノムワイド関連解析 / fatty liver dystrophy / 脂質代謝 / 交感神経 / fld / 高血圧 / 遺伝子改変マウス / SNP / 臨床血管学 / 動脈硬化症 / SNPs / 高血圧合併腎疾患 / カルシウム動態 / CAVI / 動脈硬化 / 遺伝子発現解析 / バイオインフォマティクス / ゲノム多型 Less

Elucidation of the pathophysiology of hypertension with a focus on the LPIN1 gene.
- Principal Investigator
  
  FUJIWARA AKIRA
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yokohama City University
高血圧関連遺伝子ATP2B1の腎機能および尿細管における意義に関する研究Principal Investigator
- Principal Investigator
  
  平和伸仁
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Yokohama City University
Elucidation of pathophysiology for development of new hypertension gene ATP2B1 and carotid atherosclerosis and development of treatment strategy
- Principal Investigator
  
  Yatsu Keisuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yokohama City University
The implication of ATP2B1 gene in blood pressure regulation and Ca homeostasisPrincipal Investigator
- Principal Investigator
  
  Hirawa Nobuhito
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Yokohama City University
Analysis of new candidate genes for essential hypertension: ATP2B1 gene and LPIN1 gene
- Principal Investigator
  
  UMEMURA Satoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Yokohama City University
The effects of ATP2B1, a hypertension susceptibility gene, on blood pressure and organ injuries.Principal Investigator
- Principal Investigator
  
  Hirawa Nobuhito
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Yokohama City University
Functional analysis of the new three disease-susceptibility genes for essential hypertension
- Principal Investigator
  
  UMEMURA Satoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Yokohama City University
The implications of tissue kallikrein gene polymorphisms in chronic kidney disease.Principal Investigator
- Principal Investigator
  
  HIRAWA Nobuhito
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Yokohama City University
組織カリクレイン遺伝子多型と高血圧臓器障害における遺伝子解析の意義Principal Investigator
- Principal Investigator
  
  平和伸仁
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Yokohama City University

[Book] 日本高血圧学会高血圧診療ガイド20202020
- Author(s)
  土橋卓也、平和　伸仁他日本高血圧学会高血圧診療ガイド2020作成委員会
- Total Pages
  119
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-19K08709
[Book] 腎血管性高血圧症2015
- Author(s)
  平和伸仁
- Total Pages
  2096
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-25461249
[Book] 遺伝性高血圧血圧 162009
- Author(s)
  谷津圭介, 平和伸仁, 梅村敏
- Data Source
  KAKENHI-PROJECT-20390239
[Journal Article] ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population2024
- Author(s)
  Kobayashi Yusuke、Yatsu Keisuke、Haruna Aiko、Kawano Rina、Ozawa Moe、Haze Tatsuya、Komiya Shiro、Suzuki Shota、Ohki Yuki、Fujiwara Akira、Saka Sanae、Hirawa Nobuhito、Toya Yoshiyuki、Tamura Kouichi
- Journal Title
  
  The Journal of Clinical Hypertension
  
  Volume: 26 Issue: 4 Pages: 355-362
- DOI
  10.1111/jch.14785
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08709
[Journal Article] LPIN1 is a new target gene for essential hypertension2022
- Author(s)
  Fujiwara Akira、Ozawa Moe、Sumida Koichiro、Hirawa Nobuhito、Yatsu Keisuke、Ichihara Nao、Haze Tatsuya、Komiya Shiro、Ohki Yuki、Kobayashi Yusuke、Wakui Hiromichi、Tamura Kouichi
- Journal Title
  
  Journal of Hypertension
  
  Volume: 40(3) Issue: 3 Pages: 536-543
- DOI
  10.1097/hjh.0000000000003046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08586, KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-20K07786, KAKENHI-PROJECT-20K21606, KAKENHI-PROJECT-19K08709
[Journal Article] 血圧管理2020
- Author(s)
  平和　伸仁
- Journal Title
  
  腎と透析
  
  Volume: 88 Pages: 778-782
- Data Source
  KAKENHI-PROJECT-19K08709
[Journal Article] 高血圧管理および治療の基本方針　Update2020
- Author(s)
  平和　伸仁
- Journal Title
  
  内科
  
  Volume: 125 Pages: 189-192
- Data Source
  KAKENHI-PROJECT-19K08709
[Journal Article] 高血圧ガイドライン20192020
- Author(s)
  平和　伸仁、梅村　敏
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 109 Pages: 778-783
- Data Source
  KAKENHI-PROJECT-19K08709
[Journal Article] JSH2019ガイドラインの作成プロセスと要点2020
- Author(s)
  平和　伸仁、梅村　敏
- Journal Title
  
  CURRENT THERAPY
  
  Volume: 38 Pages: 8-13
- Data Source
  KAKENHI-PROJECT-19K08709
[Journal Article] Atherosclerosis of the carotid bulb is associated with the severity of orthostatic hypotension in non-diabetic adult patients: a cross-sectional study.2018
- Author(s)
  Kobayashi Y, Ishiguro H, Fujikawa T, Kobayashi H, Sumida K, Kagimoto M, Okuyama Y, Ehara Y, Katsumata M, Fujita M, Fujiwara A, Saka S, Yatsu K, Hirawa N, Toya Y, Yasuda G, Umemura S, Tamura K.
- Journal Title
  
  Clin Exp Hypertens.
  
  Volume: Apr 19 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09477
[Journal Article] Reduced secretion of parathyroid hormone and hypocalcemia in systemic heterozygous ATP2B1-null hypertensive mice2018
- Author(s)
  Ehara Yosuke、Hirawa Nobuhito、Sumida Kouichiro、Fujiwara Akira、Kagimoto Minako、Ooki-Okuyama Yuki、Fujita Megumi、Katsumata Mari、Kobayashi Yusuke、Saka Sanae、Katou Ikuma、Yatsu Keisuke、Umemura Satoshi、Tamura Kouichi
- Journal Title
  
  Hypertension Research
  
  Volume: 41 Issue: 9 Pages: 699-707
- DOI
  10.1038/s41440-018-0067-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09477, KAKENHI-PROJECT-16K09648
[Journal Article] The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice.2018
- Author(s)
  Okuyama Y, Hirawa N, Fujita M, Fujiwara A, Ehara Y, Yatsu K, Sumida K, Kagimoto M, Katsumata M, Kobayashi Y, Saka S, Umemura S, Tamura K.
- Journal Title
  
  Hypertens Res.
  
  Volume: 41(2) Issue: 2 Pages: 80-87
- DOI
  10.1038/hr.2017.92
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09477, KAKENHI-PROJECT-16K09648
[Journal Article] Enhancement of intrarenal plasma membrane calcium pump isoform 1 expression in chronic angiotensin II-infused mice2017
- Author(s)
  Wakui Hiromichi、Sumida Koichiro、Fujita Megumi、Ohtomo Yuta、Ohsawa Masato、Kobayashi Ryu、Uneda Kazushi、Azushima Kengo、Haruhara Kotaro、Yatsu Keisuke、Hirawa Nobuhito、Minegishi Shintaro、Ishigami Tomoaki、Umemura Satoshi、Tamura Kouichi
- Journal Title
  
  Physiological Reports
  
  Volume: 5 Issue: 11 Pages: e13316-e13316
- DOI
  10.14814/phy2.13316
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09647, KAKENHI-PROJECT-16K09648, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-17H06993, KAKENHI-PROJECT-15K09293
[Journal Article] 高血圧の遺伝要因：ATP2B1の意義2015
- Author(s)
  平和伸仁
- Journal Title
  
  腎と透析
  
  Volume: 79 Pages: 353-356
- Data Source
  KAKENHI-PROJECT-25461249
[Journal Article] Genome-wide association study of IgA nephropathy using 23 465 microsatellite markers in a Japanese population.2015
- Author(s)
  Saka S, Hirawa N, Oka A, Yatsu K, Hirukawa T, Yamamoto R, Matsusaka T, Imai E, Narita I, Endoh M, Ichikawa I, Umemura S, Inoko H.
- Journal Title
  
  J Hum Genet.
  
  Volume: 60・10 Issue: 10 Pages: 573-80
- DOI
  10.1038/jhg.2015.88
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23249047, KAKENHI-PROJECT-25461249
[Journal Article] Effects of doxazosin as the third agent on morning hypertension and position-related blood pressure changes in diabetic patients with chronic kidney disease.2015
- Author(s)
  Yasuda, G, Saka, S, Ando, D, Hirawa, N
- Journal Title
  
  Clin Exp Hypertens
  
  Volume: 37 Issue: 1 Pages: 75-81
- DOI
  10.3109/10641963.2014.913599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461249
[Journal Article] Impaired NO Production and Increased Blood Pressure in Systemic Heterozygous ATP2B1 Null Mice2014
- Author(s)
  Akira Fujiwara, Nobuhito Hirawa, Megumi Fujita, Yusuke Kobayashi, Yuki Okuyama, Keisuke Yatsu, Mari Katsumata, Yuichiro Yamamoto, Naoaki Ichihara, Sanae Saka, Yoshiyuki Toya, Gen Yasuda, Yoshio Goshima, Yasuharu Tabara, Tetsuro Miki, Hirotsugu Ueshima, Yoshihiro Ishikawa and Satoshi Umemura
- Journal Title
  
  Journal of Hypertension
  
  Volume: e-pub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461249
[Journal Article] Impaired no production and increased blood pressure in systemic heterozygous atp2b1 null mice2014
- Author(s)
  Fujiwara A, Hirawa N, Fujita M, Kobayashi Y, Okuyama Y, Yatsu K, Katsumata M, Yamamoto Y, Ichihara N, Saka S, Toya Y, Umemura S.
- Journal Title
  
  Jourenal of Hypertension
  
  Volume: Published Ahead-of-Print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293196
[Journal Article] Impaired NO Production and Increased Blood Pressure in Systemic Heterozygous ATP2B1 Null Mice.2014
- Author(s)
  Fujiwara A, Hirawa N, Fujita M, Kobayashi Y, Okuyama Y, Yatsu K, Katsumata M, Yamamoto y, Ichihara N, Saka S, Toya Y, Yasuda G, Tabara Y, Miki T, Ueshima H, Ishikawa Y, and Umemura S
- Journal Title
  
  J Hypertension.
  
  Volume: 32 Issue: 7 Pages: 1415-1423
- DOI
  10.1097/hjh.0000000000000206
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22136009, KAKENHI-PROJECT-24390084, KAKENHI-PROJECT-24390200, KAKENHI-PROJECT-25293196, KAKENHI-PROJECT-25461249, KAKENHI-PROJECT-25670131
[Journal Article] ATP2B1 and blood pressure: from associations to pathophysiology.2013
- Author(s)
  Hirawa N, Fujiwara A, Umemura S.
- Journal Title
  
  Curr Opin Nephrol Hypertens.
  
  Volume: Mar, 22 Issue: 2 Pages: 177-184
- DOI
  10.1097/mnh.0b013e32835da4ca
- Data Source
  KAKENHI-PROJECT-25293196
[Journal Article] Cardiac-specific activation of angiotensin II type 1 receptor associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice.2010
- Author(s)
  Tamura K, Hirawa N, Umemura S, et al.
- Journal Title
  
  Hypertension
  
  Volume: 55 Pages: 1157-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390239
[Journal Article] Common variants in the ATP2B1 gene are associated with susceptibility to hyper-tension : the Japanese Millennium Genome Project.2010
- Author(s)
  Tabara Y, Hirawa N, Umemura S, et al.
- Journal Title
  
  Hypertension 56
  
  Pages: 973-980
- Data Source
  KAKENHI-PROJECT-20390239
[Journal Article] Common variants in the ATP2B1 gene are associated with susceptibility to hypertension : the Japanese Millennium Genome Project.2010
- Author(s)
  Tabara Y, Hirawa N, Umemura S, et al.
- Journal Title
  
  Hypertension
  
  Volume: 56 Pages: 973-980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390239
[Journal Article] Cardiac-specific activation of angiotensin II type 1 receptor associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II infused mice.2010
- Author(s)
  Tamura K, Hirawa N, Umemura S, et al.
- Journal Title
  
  Hypertension 55
  
  Pages: 1157-64
- Data Source
  KAKENHI-PROJECT-20390239
[Journal Article] 遺伝性高血圧2009
- Author(s)
  谷津圭介, 平和伸仁, 梅村敏
- Journal Title
  
  血圧 16
  
  Pages: 661-664
- Data Source
  KAKENHI-PROJECT-20390239
[Journal Article] Association of TNFRSF4 gene polymorphisms with essential hypertension.2008
- Author(s)
  Mashimo Y, Suzuki Y, Hatori K, Hirawa N, Umemura S, et al.
- Journal Title
  
  J Hypertens 26(5)
  
  Pages: 902-913
- Data Source
  KAKENHI-PROJECT-20390239
[Journal Article] Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach : the millennium genome project for hypertension.2008
- Author(s)
  Kohara K, Tabara Y, Nakura J, Umemura S, Hirawa N, et al.
- Journal Title
  
  Hypertens Res 31(2)
  
  Pages: 203-212
- NAID
  10024359591
- Data Source
  KAKENHI-PROJECT-20390239
[Journal Article] The gene, synthesis, function of kallikrei2005
- Author(s)
  Hirawa N, Umemura S.
- Journal Title
  
  Nippon Rinsho. 63 Suppl 3
  
  Pages: 363-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571029
[Journal Article] カリクレインの遺伝子、生合成、機能.2005
- Author(s)
  平和伸仁, 梅村敏
- Journal Title
  
  日本臨床 63
  
  Pages: 363-368
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571029
[Journal Article] Prostaglandin/bradykinin2004
- Author(s)
  Hirawa N, Umemura S.
- Journal Title
  
  Nippon Rinsho. 62 Suppl 6
  
  Pages: 183-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571029
[Journal Article] プロスタグランジン/ブラジキニン2004
- Author(s)
  平和伸仁, 梅村敏
- Journal Title
  
  日本臨床 62
  
  Pages: 183-188
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571029
[Patent] Identification of hypertension Susceptibility gene group2015
- Inventor(s)
  Miki T, Hirawa N 他7名
- Industrial Property Rights Holder
  愛媛大学、横浜市大、滋賀医大横浜市大、滋賀医大
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-21
- Acquisition Date
  2015-12-16
- Overseas
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] Features and Issues of JSH2019 Aiming to improve Blood Pressure Control JSH2019で取り上げられたこと、明らかにされたこと2023
- Author(s)
  平和　伸仁
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08709
[Presentation] JSH Guideline for the Management of Hypertension 2019 (JSH2019) ~ Concept and Subsequent Challenges ~2022
- Author(s)
  Nobuhito Hirawa
- Organizer
  The 29th Scientific Meeting of the International Society of Hypertension (ISH 2022 Kyoto)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08709
[Presentation] JSH2019で残した課題と新たな課題2022
- Author(s)
  平和　伸仁
- Organizer
  第10回臨床高血圧フォーラム
- Data Source
  KAKENHI-PROJECT-19K08709
[Presentation] 血管平滑筋特異的ATP2B1ノックアウトマウスにおける高血圧のメカニズムと降圧薬の効果2018
- Author(s)
  奥山由紀、平和伸仁、藤田恵美、藤原亮、江原洋介、谷津圭介、角田剛一郎、鍵本美奈子、勝又真理、小林雄祐、坂早苗、梅村敏、田村功一
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-16K09648
[Presentation] Renal plasma membrane calcium pump isoform 1 expression is involved in hypertension-related kidney injury.2018
- Author(s)
  Koichiro Sumida, Hiromichi Wakui, Megumi Fujita,Yuta Ohtomo, Masato Ohsawa, Ryu Kobayashi, Kengo Azushima, Kotaro Haruhara, Yuki Oki, Yousuke Ehara, Shota Suzuki, Keisuke Yatsu, Nobuhito Hirawa, Shintaro Minegishi, Tomoaki Ishigami, Yosiyuki Toya, Satoshi Umemura and Kouichi Tamura.
- Organizer
  ISN frontier 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09477
[Presentation] Decreased blood pressure in vascular smooth muscle specific ATP2B1 overexpressing mice2017
- Author(s)
  Yosuke Ehara, Nobuhito Hirawa, Kouichiro Sumida, Minako Kagimoto, Yuki Ooki, Megumi Fujita, Mari Katumata, Akira Fujiwara, Yusuke Kobayashi, Sanae Saka, Ikuma Katou, Keisuke Yatsu, Satoshi Umemura, and Kouichi Tamura
- Organizer
  American Society of Nephrology Kidney Week 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09648
[Presentation] Calcium metabolism in systemic heterozygous ATP2B1-null mice2017
- Author(s)
  Yosuke Ehara, Nobuhito Hirawa, Kouichiro Sumida, Minako Kagimoto, Yuki Ooki, Megumi Fujita, Mari Katumata, Akira Fujiwara, Yusuke Kobayashi, Sanae Saka, Ikuma Katou, Keisuke Yatsu, Satoshi Umemura, and Kouichi Tamura
- Organizer
  American Society of Nephrology Kidney Week 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09648
[Presentation] 血管平滑筋特異的ATP2B1ノックアウトマウスはCaチャネル拮抗薬に対する薬剤応答性を認めた2016
- Author(s)
  奥山由紀，角田剛一郎，鍵本美奈子, 江原洋介，勝又真理，藤田恵美，藤原亮，小林雄祐，坂早苗，谷津圭介，梅村敏，平和伸仁
- Organizer
  第３９回日本高血圧学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-16K09648
[Presentation] ATP2B1血管平滑筋過剰発現マウスの作製と解析2016
- Author(s)
  江原洋介，角田剛一郎，鍵本美奈子，奥山由紀，勝又真理，藤田恵美，藤原亮，小林雄祐，坂早苗，谷津圭介，安田元，梅村敏，平和伸仁
- Organizer
  第３９回日本高血圧学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-16K09648
[Presentation] ATP2B1の血管内皮における血圧への影響：血管内皮特異的ノックアウトマウスを用いた検討2015
- Author(s)
  奥山由紀，藤原亮, 平和伸仁, 鍵本美奈子, 江原洋介, 勝又真理, 藤田恵美，小林雄祐，坂早苗，谷津圭介，戸谷義幸，梅村敏
- Organizer
  日本臨床分子医学会
- Place of Presentation
  京都
- Year and Date
  2015-04-10
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] 遠位尿細管特異的ATP2B1欠損マウスは食塩感受性高血圧を呈する2015
- Author(s)
  藤田恵美、平和伸仁、江原洋介、奥山由紀、谷津圭介、梅村敏
- Organizer
  第51回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] 高血圧感受性遺伝子ATP2B1の血管平滑筋における役割～血管平滑筋特異的ATP2B1KOマウスを用いた降圧薬の効果比較～．2015
- Author(s)
  奥山由紀, 平和伸仁, 鍵本美奈子, 江原洋介, 勝又真理, 藤田恵美，藤原亮, 小林雄祐，坂早苗，谷津圭介，戸谷義幸，梅村敏
- Organizer
  第51回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] 全身ヘテロATP2B1欠損マウスにおける高血圧と低Ca血症の関連について2015
- Author(s)
  江原洋介、藤原亮、平和伸仁、角田剛一朗、奥山由紀、藤田恵美、勝又真理、小林雄祐、坂早苗、谷津圭介、戸谷義幸、安田元、梅村敏
- Organizer
  第38回日本高血圧学会総会
- Place of Presentation
  ひめぎんホール（愛媛県松山市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-25293196
[Presentation] 全身ヘテロATP2B1欠損マウスにおける高血圧と低Ca血症2015
- Author(s)
  江原洋介，藤原亮，平和伸仁, 角田剛一郎，奥山由紀，藤田恵美，勝又真理，小林雄祐，坂早苗，谷津圭介，戸谷義幸，安田元，梅村敏
- Organizer
  第51回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] 全身ヘテロATP2B1欠損マウスにおける高血圧と低Ca血症について2015
- Author(s)
  江原洋介，藤原亮，平和伸仁, 角田剛一郎，奥山由紀，藤田恵美，勝又真理，小林雄祐，坂早苗，谷津圭介，戸谷義幸，安田元，梅村敏
- Organizer
  第38回日本高血圧学会総会
- Place of Presentation
  松山
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] ゲノムワイド解析による高血圧遺伝子ATP2B1の発見と遺伝子改変マウスを用いた機能解析.2013
- Author(s)
  平和伸仁、小林雄祐、藤原亮、藤田恵美、奥山由紀、勝又真理、坂早苗、山本有一郎、谷津圭介、戸谷義幸、安田元、梅村敏.
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] ヒトゲノムワイド解析の成果を遺伝子改変動物を用いて証明・発展させる.2013
- Author(s)
  平和伸仁、小林雄祐、藤原亮、藤田恵美、奥山由紀、坂早苗、谷津圭介、梅村敏.
- Organizer
  第49回高血圧疾患モデル学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] ATP2B1遺伝子の全身ヘテロノックアウトマウスにおける血圧上昇とNO産生の低下.2013
- Author(s)
  藤原亮、平和伸仁、奥山由紀、藤田恵美、小林雄祐、谷津圭介、戸谷義幸、梅村敏.
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] 高血圧感受性遺伝子ATP2B1の機能遠位尿細管特異的ATP2B1欠損マウスを用いた検討.2013
- Author(s)
  藤田恵美，平和伸仁，奥山由紀，藤原亮，宮崎喜子，坂早苗，小林雄祐，長濱清隆，山本有一郎，谷津圭介，戸谷義幸，梅村敏.
- Organizer
  第56回日本腎臓学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] 本態性高血圧症の新規候補遺伝子SMOC-2の高密度SNP関連解析2008
- Author(s)
  谷津圭介, 平和伸仁, 梅村敏, など
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-20390239
[Presentation] 本態性高血圧症の新規候補遺伝子SMOC-2の高密度SNP関連解析2008
- Author(s)
  谷津圭介, 平和伸仁, 梅村敏, など
- Organizer
  第31回日本高血圧学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-20390239
[Presentation] 本態性高血圧症のQTL解析の結果と遺伝・環境因子相互作用の検討2008
- Author(s)
  谷津圭介, 平和伸仁, 梅村敏, など
- Organizer
  第51回日本腎臓学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-20390239
[Presentation] 遺伝子解析からモデル動物での機能解析への戦略：ATP2B1遺伝子欠損マウス.
- Author(s)
  谷津圭介、平和伸仁、奥山由紀、江原洋介、藤田恵美、藤原亮、小林雄佑、坂早苗、戸谷義幸、梅村敏.
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] ゲノムワイド解析による高血圧関連遺伝子ATP2B1の発見と遺伝子改変マウスを用いた機能解析
- Author(s)
  平和伸仁、小林雄祐、藤原亮、藤田恵美、奥山由紀、勝又真理、坂早苗、山本有一郎、谷津圭介、戸谷義幸、梅村敏
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Data Source
  KAKENHI-PROJECT-25293196
[Presentation] 長期にわたる遠位尿細管ATP2B1欠損が及ぼす影響：高齢マウスを用いた検討.
- Author(s)
  中山雄太、藤田恵美、平和伸仁、江原洋介、奥山由紀、勝又真理、藤原亮、小林雄佑、坂早苗、谷津圭介、戸谷義幸、梅村敏.
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] ATP2B1遺伝子の全身ヘテロノックアウトマウスにおける臓器障害とカルシウム代謝.
- Author(s)
  藤原亮、平和伸仁、江原洋介、奥山由紀、藤田恵美、勝又真理、小林雄佑、坂早苗、谷津圭介、戸谷義幸、梅村敏.
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] 遺伝子解析からモデル動物での機能解析への戦略：ATP2B1遺伝子欠損マウス
- Author(s)
  谷津　圭介、平和　伸仁、奥山　由紀、江原　洋介、藤田　恵美、藤原　亮、小林　雄祐、坂　早苗、戸谷　義幸、梅村　敏
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-10-17 – 2014-10-19
- Invited
- Data Source
  KAKENHI-PROJECT-25293196
[Presentation] 遠位尿細管特異的ATP2B1欠損マウスの食塩負荷による血圧変動について.
- Author(s)
  江原洋介、藤田恵美、平和伸仁、奥山由紀、勝又真理、藤原亮、坂早苗、小林雄佑、谷津圭介、戸谷義幸、安田元、梅村敏.
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] 高血圧感受性遺伝子ATP2B1遠位尿細管特異的欠損マウスの解析.
- Author(s)
  藤田恵美、平和伸仁、江原洋介、奥山由紀、勝又真理、藤原亮、小林雄佑、涌井広道、坂早苗、谷津圭介、橋本達夫、戸谷義幸、梅村敏.
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] LPIN1欠損マウスを用いたLPIN1遺伝子の血圧制御機能の解析
- Author(s)
  奥山　由紀、谷津　圭介、江原　洋介、勝又　真理、藤田　恵美、藤原　亮、小林　雄祐、坂　早苗、平和　伸仁、戸谷　義幸、梅村　敏
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市）
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-25293196
[Presentation] Distal tubules-specific knockput of ATP2B1 is associated with severe polyuria and hypercalciuria without hypertension.
- Author(s)
  1.Fujita M, Hirawa N, Okuyama Y, Fujiwara A, Kobayashi Y, Saka S, Yatsu K, Umemura S.
- Organizer
  The 14th Asian Pacific Congress of Nephrology.
- Place of Presentation
  Shinagawa Prince Hotel
- Year and Date
  2014-05-14 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] ATP2B1遺伝子の全身ヘテロノックアウトマウスにおける臓器障害とカルシウム代謝
- Author(s)
  藤原　亮、平和　伸仁、江原　洋介、奥山　由紀、藤田　恵美、勝又　真理、小林　雄祐、坂　早苗、谷津　圭介、戸谷　義幸、梅村　敏
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-25293196
[Presentation] 本態性高血圧の成因における遺伝子変異～GWASの意義とATP2B1の働き～
- Author(s)
  平和　伸仁
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-10-17 – 2014-10-19
- Invited
- Data Source
  KAKENHI-PROJECT-25293196
[Presentation] ATP2B1遺伝子の全身ヘテロノックアウトマウスにおける血圧上昇とNO産生の低下
- Author(s)
  藤原亮、平和伸仁、奥山由紀、藤田恵美、小林雄祐、谷津圭介、戸谷義幸、梅村敏
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Data Source
  KAKENHI-PROJECT-25293196
[Presentation] Distal tubules-specific knockout of ATP2B1 is associated with severe polyuria hypertension.
- Author(s)
  Fujita M, Hirawa N, Okuyama Y, Fujiwara A, Kobayashi Y, Saka S, Yatsu K, Nagahama K, Umemura S
- Organizer
  The 14th Asian Pacific Congress of Nephrology
- Place of Presentation
  品川プリンスホテル（東京都港区）
- Year and Date
  2014-05-14 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25293196
[Presentation] Ca transporter（PMCA1）をコードするATP2B1のSNAP多型を用いたテーラーメードー医療の可能性　GEANE研究サブスタディー.
- Author(s)
  谷津圭介、神出計、平和伸仁、奥山由紀、江原洋介、藤田恵美、藤原亮、小林雄佑、坂早苗、戸谷義幸、花田裕典、宮田敏行、河野雄平、梅村敏.
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-25461249
[Presentation] 本態性高血圧の成因における遺伝子変異.　GWASの意義とATP2B1の働き.
- Author(s)
  平和伸仁
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Invited
- Data Source
  KAKENHI-PROJECT-25461249

1. YATSU Keisuke (10457856)

# of Collaborated Projects: 6 results

# of Collaborated Products: 39 results
2. UMEMURA Satoshi (00128589)

# of Collaborated Projects: 5 results

# of Collaborated Products: 45 results
3. OKA Akira (80384866)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MIZUKI Nobuhisa (90336579)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. FUJIWARA AKIRA (20733447)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. INOKO Hidetoshi (10101932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAMURA Koichi (40285143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. KOBAYASHI Yusuke (60612629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
9. 坂早苗 (90723320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. WAKUI Hiromichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. ICHIKAWA Iekuni

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 大澤正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 松阪泰二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 石川義弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 藤田孝之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirawa Nobuhito 平和 伸仁

HIRAWA Nobuhito 平和 伸仁

Research Projects

Research Products

Co-Researchers

Elucidation of the pathophysiology of hypertension with a focus on the LPIN1 gene.

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Review Section

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高血圧関連遺伝子ATP2B1の腎機能および尿細管における意義に関する研究Principal Investigator

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Elucidation of pathophysiology for development of new hypertension gene ATP2B1 and carotid atherosclerosis and development of treatment strategy

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The implication of ATP2B1 gene in blood pressure regulation and Ca homeostasisPrincipal Investigator

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Analysis of new candidate genes for essential hypertension: ATP2B1 gene and LPIN1 gene

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The effects of ATP2B1, a hypertension susceptibility gene, on blood pressure and organ injuries.Principal Investigator

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Functional analysis of the new three disease-susceptibility genes for essential hypertension

Principal Investigator

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The implications of tissue kallikrein gene polymorphisms in chronic kidney disease.Principal Investigator

Principal Investigator

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組織カリクレイン遺伝子多型と高血圧臓器障害における遺伝子解析の意義Principal Investigator

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[Book] 日本高血圧学会高血圧診療ガイド20202020

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[Book] 腎血管性高血圧症2015

Author(s)

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[Book] 遺伝性高血圧 血圧 162009

Author(s)

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[Journal Article] ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population2024

Author(s)

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DOI

Data Source

[Journal Article] LPIN1 is a new target gene for essential hypertension2022

Author(s)

Journal Title

Hirawa Nobuhito 平和伸仁

HIRAWA Nobuhito 平和伸仁

[Book] 遺伝性高血圧血圧 162009

[Journal Article] 高血圧管理および治療の基本方針　Update2020

[Journal Article] Genome-wide association study of IgA nephropathy using 23 465 microsatellite markers in a Japanese population.2015