Horie Hisanaga 堀江久永

… Alternative Names

堀江久永ホリエヒサナガ

HORIE Hisanaga 堀江久永

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Researcher Number	20316532
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 自治医科大学, 医学部, 教授 2007 – 2009: Jichi Medical University, 医学部, 講師 2003 – 2005: 自治医科大学, 医学部, 講師 2001 – 2002: 自治医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Digestive surgery / Rehabilitation science/Welfare engineering / Digestive surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Digestive surgery
Keywords	Principal Investigator 小腸大腸肛門外科学 / 消化器外科学 / 癌 / LuM1 / 免疫放射線療法 / abscopal effect / 免疫療法 / アデノシン / 放射線療法 / Abscopal effect … More / 接着 / CD73 / 放射線治療 / 肺転移 / 直腸癌 / 長期臥床 / 重度身体障害者 / ポータブル / シリコンマット / 空気圧コントロール / 送気ユニット / 褥創防止 / 腸内細菌叢 / 大腸癌予防 / プロバイオティクス … More Except Principal Investigator 直腸癌 / メトホルミン / QOL / 転移 / 発癌 / 糖尿病 / 多重免疫染色 / 腫瘍浸潤リンパ球 / 好中球細胞外トラップ / 免疫 / 大腸癌 / フェロトーシス / 化学放射線療法耐性 / 発がん / 再発 / 上部消化管癌 / 大網 / 腹腔内マクロファージ / がん免疫微小環境 / 肝転移 / 大網乳班 / T細胞 / マクロファージ / 腹腔免疫 / 大腸乳斑 / 腹膜播種 / 胃癌 / コリン作動性シグナル / 迷走神経 / アデノシン / Abscopal Effect / 肺転移 / Abscopal Effect / 免疫放射線療法 / reconstruction / rectal cancer / sphincter / neoanus / アヌス / 人工肛門 / 肛門機能再建 / 再建 / 括約筋 / 新肛門 Less

化学放射線療法耐性直腸癌に対するフェロトーシス誘導療法の開発
- Principal Investigator
  
  井上賢之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Jichi Medical University
Role of neutrophil extracellular traps in the pathophysiology of colorectal cancer
- Principal Investigator
  
  鯉沼広治
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jichi Medical University
Oncological significance of vagotomy in upper gastrointestinal surgery
- Principal Investigator
  
  Hosoya Yoshinori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jichi Medical University
Novel radioimmunotherapy for rectal cancer based on the tumor metabolism
- Principal Investigator
  
  Koinuma Koji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jichi Medical University
Radiation and immune checkpoint inhibition for the treatment of advanced rectal cancer with distant micrometastasisPrincipal Investigator
- Principal Investigator
  
  Horie Hisanaga
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Jichi Medical University
Portable sore pressure prevention device to sick person who needs prolonged immobility DevelopmentPrincipal Investigator
- Principal Investigator
  
  HORIE Hisanaga
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Jichi Medical University
Study on the role of pudendal nerve innervation and the optimum conditions
- Principal Investigator
  
  OKADA Masaki
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  JICHI MEDICAL SCHOOL
プロバイオティクス(生菌製剤)による大腸癌予防Principal Investigator
- Principal Investigator
  
  堀江久永
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Jichi Medical University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Metformin may improve the outcome of patients with colorectal cancer and type 2 diabetes mellitus partly through effects on neutrophil extracellular traps.2023
- Author(s)
  Saito A, Koinuma K, Kawashima R, Miyato H, Ohzawa H, Horie H, Yamaguchi H, Kawahira H, Mimura T, Kitayama J, Sata N.
- Journal Title
  
  BJC Reports
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08901
[Journal Article] Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model2022
- Author(s)
  Tojo Mineyuki、Miyato Hideyo、Koinuma Koji、Horie Hisanaga、Tsukui Hidenori、Kimura Yuki、Kaneko Yuki、Ohzawa Hideyuki、Yamaguchi Hironori、Yoshimura Kotaro、Lefor Alan Kawarai、Sata Naohiro、Kitayama Joji
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1
- DOI
  10.1038/s41598-022-11236-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08901, KAKENHI-PROJECT-23K24411
[Journal Article] The Regional Specificity of Mucosa-Associated Microbiota in Patients with Distal Colorectal Cancer2022
- Author(s)
  Kono Yoshihiko、Inoue Ryo、Teratani Takumi、Tojo Mineyuki、Kumagai Yuko、Morishima So、Koinuma Koji、Lefor Alan Kawarai、Kitayama Joji、Sata Naohiro、Horie Hisanaga
- Journal Title
  
  Digestion
  
  Volume: 103 Issue: 2 Pages: 141-149
- DOI
  10.1159/000519487
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08901, KAKENHI-PROJECT-22K16543, KAKENHI-PROJECT-21K20958
[Journal Article] CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model2020
- Author(s)
  H. Tsukui, H. Horie, K. Koinuma, H. Ohzawa, Y. Sakuma, Y. Hosoya, H. Yamaguchi, K. Yoshimura, A. K. Lefor, N. Sata, J. Kitayama.
- Journal Title
  
  BMC Cancer
  
  Volume: 20(1) Issue: 1 Pages: 411-411
- DOI
  10.1186/s12885-020-06893-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09225
[Journal Article] CD73 Blockade Enhances the Local and Abscopal Effects of Radiotherapy in a Murine Rectal Cancer Model2020
- Author(s)
  Hidenori Tsukui, Hisanaga Horie, Koji Koinuma, Hideyuki Ohzawa, Yasunaru Sakuma, Yoshinori Hosoya, Hironori Yamaguchi, Kotaro Yoshimura, Alan Kawarai Lefor , Naohiro Sata , Joji Kitayama.
- Journal Title
  
  BMC Cancer
  
  Volume: 20 Pages: 411-411
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] 大腸がん患者の術直後の血中低比重好中球比率が補助化学療法の再発予測因子となるか2022
- Author(s)
  風當ゆりえ, 北山丈二, 金子勇貴, 高橋和也, 木村有希, 熊谷祐子, 太白健一, 直井大志, 佐田友藍, 大澤英之, 宮戸秀世, 鯉沼広治, 堀江久永, 山口博紀,佐田尚宏
- Organizer
  第60回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08901
[Presentation] 大腸癌患者の術後末梢血中低比重好中球と予後の関連性2022
- Author(s)
  風當ゆりえ, 北山丈二, 金子勇貴, 髙橋和也, 木村勇希, 太田学, 熊谷祐子, 太白健一, 直井大志, 佐田友藍, 井上賢之, 大澤英之, 宮戸秀世, 鯉沼広治, 佐久間康成, 堀江久永, 細谷好則,佐田尚宏
- Organizer
  第77回日本大腸肛門病学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08901
[Presentation] Expression of programmed cell death ligand 1 in peripheral blood monocytes is associated with the response to preoperative chemoradiotherapy for rectal cancer.2022
- Author(s)
  高橋礼, 東條峰之, 津久井秀則, 松宮美沙希, 金子勇貴, 風當ゆりえ, 木村有希, 髙橋和也, 大澤英之, 宮戸秀世, 鯉沼広治, 山口博紀, 佐久間康成, 川平洋, 堀江久永, 細谷好則, 味村俊樹, アラン瓦井レフォー, 北山丈二,佐田尚宏
- Organizer
  第26回日本外科病理学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08901
[Presentation] 直腸癌術前放射線化学療法の奏効率と末梢血単核球上PDL1との関連2021
- Author(s)
  東條峰之, 津久井秀則, 金子勇貴, 風當ゆりえ, 木村有希, 髙橋和也, 齋藤晶, 大澤英之, 宮戸秀世, 鯉沼広治, 堀江久永, 佐田尚宏，北山丈二
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09225
[Presentation] 直腸癌に対する術前CRTと選択的側方郭清併用による治療成績2020
- Author(s)
  堀江久永, 鯉沼広治, 巷野佳彦, 佐田友藍, 直井大志, 佐久間康成, 細谷好則, 味村俊樹, 北山丈二, 佐田尚宏
- Organizer
  第75回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-19K09225
[Presentation] CD73 targeting therapy enhances the antitumor effect of radiotherapy in rectal cancer2020
- Author(s)
  津久井秀則, 堀江久永, 大澤英之, 山口博紀, 佐久間康成, 川平洋, 細谷好則, 味村俊樹, 鯉沼広治, 吉村浩太郎, Alan Lefor, 佐田尚宏, 北山丈二
- Organizer
  第120回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09225
[Presentation] Combination therapy of local radiation and metformin can suppress the spontaneous lung metastases of murine tumor2020
- Author(s)
  東條峰之, 津久井秀則, 齋藤晶, 高橋和也, 木村有希, 熊谷祐子, 宮戸秀世, 大澤英之, 鯉沼広治, 堀江久永, 佐田尚宏, 北山丈二
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09225
[Presentation] CD73 targeting therapy enhances the antitumor effect of radiotherapy in rectal caner.2019
- Author(s)
  Hidenori Tsukui, Hisanaga Horie, Naohiro Sata, Kitayama. Joji.
- Organizer
  The 5th JMU Workshop for Graduate Students 2019
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] 術前CRTと側方郭清による側方リンパ節転移の制御．2019
- Author(s)
  堀江　久永，鯉沼　広治，井上　賢之，田原　真紀子，巷野　佳彦，佐久間　康成，細谷　好則，味村　俊樹，北山　丈二，佐田　尚宏．
- Organizer
  第74回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] CD73 targeting therapy enhances the antitumor effect of radiotherapy in recral caner.2019
- Author(s)
  Hidenori Tsukui., Hiedyuki Ohzawa., Hironori Yamaguchi., Sakuma. Yasunaru., Hiroshi Kawahira., Hisanaga Horie., Yoshinori Hosoya., Toshiki Mimura., Kotaro Yoshimura., Naohiro Sata., Joji Kitayama.
- Organizer
  第18回自治医科大学シンポジウム2019
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] 放射線照射直腸癌におけるアデノシン及びアデノシン産生酵素CD73発現について Adenosine and adenosine producing 5'-Nucleotidase/CD73 in irradiated rectal cancer.2019
- Author(s)
  津久井　秀則，大澤　英之，山口　博紀，佐久間　康成，細谷　好則，堀江　久永，藤井　博文，佐田　尚宏，北山　丈二．
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] 術前CRTと側方郭清による側方リンパ節転移の制御．2019
- Author(s)
  堀江　久永，鯉沼　広治，井上　賢之，田原　真紀子，巷野　佳彦，佐久間　康成，細谷　好則，味村　俊樹，北山　丈二，佐田　尚宏．
- Organizer
  第74回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-19K09225
[Presentation] 大腸癌所属リンパ節内のTリンパ球におけるPD-1の発現について．2019
- Author(s)
  津久井　秀則，齋藤　晶，東條　峰之，大澤　英之，佐久間　康成，細谷　好則，堀江久永，佐田　尚宏，北山　丈二．
- Organizer
  第74回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] 放射線化学療法(CRT) 後の直腸癌組織におけるCD73の発現2018
- Author(s)
  津久井秀則, 大澤英之, 山口博紀, 佐久間康成, 細谷好則, 堀江久永, 藤井博文, 若月優, 佐田尚宏, 北山丈二
- Organizer
  第39回癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] 担癌マウスリンパ節におけるアデノシン脱リン酸化酵素（ＣＤ39，ＣＤ73）発現についての解析(Expression of adenosine generating ecto-enzymes, CD39 and CD73, in lymphocytes in tumor bearing mouse.)2018
- Author(s)
  津久井秀則, 大澤英之, 山口博紀, 佐久間康成, 細谷好則, 堀江久永, 藤井博文, 佐田尚宏, 北山丈二
- Organizer
  第77回日本癌学会総会記事
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] Expression of adenosine generating ecto-enzymes, CD39 and CD73 in tumor bearing mouse and irradiated cell line.2018
- Author(s)
  Hidenori Tsukui, Hideyuki Ohzawa, Hironori Yamaguchi, Yasunaru Sakuma, Yoshinori Hosoya, Hisanaga Horie, Hirofumi Fuji, Naohiro Sata and Joji Kitayama.
- Organizer
  第17回自治医科大学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] 放射線化学療法(CRT)後の直腸癌組織におけるCD73の発現2018
- Author(s)
  津久井秀則, 大澤英之, 山口博紀, 佐久間康成, 細谷好則, 堀江久永, 藤井博文, 若月優, 佐田尚宏, 北山丈二
- Organizer
  第73回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] 直腸癌術前化学放射線療法における治療前後末梢血好中球リンパ球による治療効果予測2018
- Author(s)
  津久井秀則, 北山丈二, 森本光昭, 熊谷祐子, 佐田友藍, 清水徹一郎, 直井大志, 田原真紀子, 巷野佳彦, 森和亮, 伊藤誉, 井上賢之, 鯉沼広治, 佐久間康成, 細谷好則, 堀江久永, Alan Lefor, 佐田尚宏
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] Local irradiation with systemic anti-PD1 antibody may effectively suppress the micrometastasis in distant organ through the induction of abscopal effects.2017
- Author(s)
  Hidenori Tsukui, Rihito Kanamaru, Ai Sadatomo, Daishi Naoi, Tetsuichiro Shimizu, Makiko Tahara, Katsusuke Mori, Homare Ito, Mitsuaki Morimoto, Yoshihiko Kono, Yoshiyuki Inoue, Hiroyuki Maruyama, Koji Koinuma, Hisanaga Horie, Yasunaru Sakuma, Yoshinori Hosoya, Naohiro Sata, Joji Kitayama.
- Organizer
  AACR 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] 当院における局所進行下部直腸癌に対する術前化学放射線療法の有用性と課題について2017
- Author(s)
  森本光昭,津久井秀則,熊谷祐子,佐田友藍,清水徹一郎,直井大志,田原真紀子,巷野佳彦,森和亮,伊藤誉,井上賢之,鯉沼広治,佐久間康成,細谷好則,北山丈二,堀江久永,Lefor Alan ,佐田尚宏
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10649

1. 北山丈二 (20251308)

# of Collaborated Projects: 5 results

# of Collaborated Products: 25 results
2. Koinuma Koji (20382905)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
3. 井上賢之 (80375279)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. 佐田友藍 (40528585)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. OHDAIRA Takeshi (00275695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OKADA Masaki (40254924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ENDO Noriyuki (30296090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Hosoya Yoshinori (30275698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山口博紀 (20376445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
10. 田原真紀子 (30406102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 齋藤心 (60382909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 倉科憲太郎 (70382900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 宮戸秀世 (90813163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 佐久間康成 (10296105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 高橋将文 (40296108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 山田直也 (50611787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 金丸理人 (10625544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ISHIBASHI Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Horie Hisanaga 堀江 久永

堀江 久永 ホリエ ヒサナガ

HORIE Hisanaga 堀江 久永

Research Projects

Research Products

Co-Researchers

化学放射線療法耐性直腸癌に対するフェロトーシス誘導療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of neutrophil extracellular traps in the pathophysiology of colorectal cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Oncological significance of vagotomy in upper gastrointestinal surgery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel radioimmunotherapy for rectal cancer based on the tumor metabolism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Radiation and immune checkpoint inhibition for the treatment of advanced rectal cancer with distant micrometastasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Portable sore pressure prevention device to sick person who needs prolonged immobility DevelopmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the role of pudendal nerve innervation and the optimum conditions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プロバイオティクス(生菌製剤)による大腸癌予防Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Metformin may improve the outcome of patients with colorectal cancer and type 2 diabetes mellitus partly through effects on neutrophil extracellular traps.2023

Author(s)

Journal Title

Data Source

[Journal Article] Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Regional Specificity of Mucosa-Associated Microbiota in Patients with Distal Colorectal Cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD73 Blockade Enhances the Local and Abscopal Effects of Radiotherapy in a Murine Rectal Cancer Model2020

Author(s)

Journal Title

Data Source

[Presentation] 大腸がん患者の術直後の血中低比重好中球比率が補助化学療法の再発予測因子となるか2022

Author(s)

Organizer

Horie Hisanaga 堀江久永

堀江久永ホリエヒサナガ

HORIE Hisanaga 堀江久永