OHTSUKA Toshiyuki 大塚俊之

… Alternative Names

OUTSUKA Toshiyuki 大塚俊之

大塚俊之オオツカトシユキ

Less

Researcher Number	20324709
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2021: 京都大学, ウイルス・再生医科学研究所, 准教授 2015: 京都大学, ウイルス研究所, 准教授 2008 – 2013: Kyoto University, ウイルス研究所, 准教授 2004 – 2005: 京都大学, ウイルス研究所, 助教授 2003 – 2004: 京都大学, ウイルス研究所, 助手 2000: 京都大学, ウイルス研究所, 助手
Review Section/Research Field	Principal Investigator Basic Section 44020:Developmental biology-related / Neurochemistry/Neuropharmacology / 幹細胞生物学 / Neuroscience in general / Stem cell biology and medical science / Biological Sciences Except Principal Investigator Biological Sciences / General medical chemistry / Otorhinolaryngology / Biological Sciences
Keywords	Principal Investigator 再生医学 / 神経科学 / 脳・神経 / 発生・分化 / 神経発生 / 神経幹細胞 / 脳形態形成 / Hes / 脳進化 / 脳発生 … More / 幹細胞 / Shh / Sonic hedgehog / 脈絡叢 / HES / Regenerative medicine / Neuroscience / Brain・Nervous system / Development・Differentiation / 転写因子 … More Except Principal Investigator Hes1 / Hes7 / 生物時計 / 神経発生 / 認知機能 / 成体脳ニューロン新生 / 若返り / anti-Dyrk1a / Plagl2 / Ascl1 / 振動遺伝子 / 短周期振動 / Dusp7 / Erk / p21 / サイクリン依存性キナーゼ阻害因子 / 中間前駆細胞 / Neurog2 / Tbr2 / 短周期発現振動 / 細胞周期 / 光遺伝学 / 発現振動 / 神経幹細胞 / Somitogenesis / Negative feedback / 2-hour periodicity / bHLH factor / Oscillation / Biological clock / ネガティブフィードバック / 体節形成 / ネガティブフィードバック / 2時間周期 / bHLH因子 / オシレーション / 聴覚再生 / 音響障害 / 発達 / ヒト難聴等価モデル / 動態 / ラセン神経節 / トランスジェニック動物 / 組織学的検索 / 難聴モデルマウス / 難聴 / in vitro / in vivo / 難聴モデル動物 / lineage tracing / 衛星細胞 / 前駆細胞 / らせん神経節細胞 / 網膜器官培養 / ノックアウトマウス / 転写因子 / 神経前駆細胞 / グリア細胞 / 神経細胞 / 神経分化 Less

Physiological significance of ultradian oscillatory gene expression
- Principal Investigator
  
  影山龍一郎
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
Analysis of the mechanisms underlying mammalian brain development and evolutionPrincipal Investigator
- Principal Investigator
  
  Ohtsuka Toshiyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Kyoto University
Analysis of the mechanisms underlying the maintenance/differentiation of neural stem cells and brain development/evolution in mammalsPrincipal Investigator
- Principal Investigator
  
  OHTSUKA Toshiyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyoto University
Analysis of the mechanisms underlying the layer- and region-specificity during brain developmentPrincipal Investigator
- Principal Investigator
  
  OHTSUKA TOSHIYUKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Kyoto University
Visualizing and dynamic analysis of spiral ganglion cell progenitors b using of human hearing-loss model animals
- Principal Investigator
  
  KOJIMA Ken
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kyoto University
Analysis of the molecular mechanisms regulating the maintenance of multipotency and the dedifferentiation of neural stem cellsPrincipal Investigator
- Principal Investigator
  
  OHTSUKA Toshiyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Stem cell biology and medical science
- Research Institution
  Kyoto University
神経発生及び再生における幹細胞の可視化とニューロン・グリア産生機構の解明Principal Investigator
- Principal Investigator
  
  大塚俊之
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Visualization of the neural stem cells and application to the regenerative medicinePrincipal Investigator
- Principal Investigator
  
  OHTSUKA Toshiyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  幹細胞生物学
- Research Institution
  Kyoto University
Molecular analysis for the novel two-hour cycle biological clocks Hes1 and Hes7
- Principal Investigator
  
  KAGEYAMA Ryoichiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
神経発生分化におけるbHLH型転写因子の役割の解析
- Principal Investigator
  
  別所康全
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University

[Book] 実験医学（増刊号）脳神経回路と高次脳機能　榎本和生、岡部繁男編2018
- Author(s)
  影山龍一郎、大塚俊之、下條博美
- Publisher
  羊土社（東京）
- Data Source
  KAKENHI-PROJECT-18K06253
[Journal Article] Modification of gene expression and soluble factor secretion in the lateral ventricle choroid plexus: Analysis of the impacts on the neocortical development2022
- Author(s)
  Kinoshita Akira、Shqirat Mohammed、Kageyama Ryoichiro、Ohtsuka Toshiyuki
- Journal Title
  
  Neuroscience Research
  
  Volume: 177 Pages: 38-51
- DOI
  10.1016/j.neures.2021.12.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04976
[Journal Article] Sonic hedgehog expands neural stem cells in the neocortical region leading to an expanded and wrinkled neocortical surface2021
- Author(s)
  Shqirat Mohammed、Kinoshita Akira、Kageyama Ryoichiro、Ohtsuka Toshiyuki
- Journal Title
  
  Genes to Cells
  
  Volume: － Issue: 6 Pages: 399-410
- DOI
  10.1111/gtc.12847
- Data Source
  KAKENHI-PROJECT-18K06253
[Journal Article] Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain2021
- Author(s)
  Ohtsuka Toshiyuki、Kageyama Ryoichiro
- Journal Title
  
  Development
  
  Volume: 148 Issue: 4 Pages: 189191-189191
- DOI
  10.1242/dev.189191
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06480, KAKENHI-PROJECT-18K06253
[Journal Article] Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors2019
- Author(s)
  Tadanobu Matsuzaki, Toru Yoshihara, Toshiyuki Ohtsuka, Ryoichiro Kageyama
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 8251-8251
- DOI
  10.1038/s41598-019-44698-y
- NAID
  120006644067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06253
[Journal Article] Regulation of temporal properties of neural stem cells and transition timing of neurogenesis and gliogenesis during mammalian neocortical development2019
- Author(s)
  Toshiyuki Ohtsuka, Ryoichiro Kageyama
- Journal Title
  
  Seminars in Cell & Developmental Biology
  
  Volume: 95 Pages: 4-11
- DOI
  10.1016/j.semcdb.2019.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06253
[Journal Article] Dynamic control of neural stem cells by bHLH factors2019
- Author(s)
  Kageyama Ryoichiro、Shimojo Hiromi、Ohtsuka Toshiyuki
- Journal Title
  
  Neuroscience Research
  
  Volume: 138 Pages: 12-18
- DOI
  10.1016/j.neures.2018.09.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06253, KAKENHI-PROJECT-18K06254
[Journal Article] The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development2018
- Author(s)
  Ando Mitsushige、Goto Masanori、Hojo Masato、Kita Aya、Kitagawa Masashi、Ohtsuka Toshiyuki、Kageyama Ryoichiro、Miyamoto Susumu
- Journal Title
  
  Journal of Molecular Endocrinology
  
  Volume: 61 Issue: 3 Pages: 127-138
- DOI
  10.1530/jme-18-0090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06253, KAKENHI-PLANNED-16H06480
[Journal Article] Hes5 regulates the transition timing of neurogenesis and gliogenesis in mammalian neocortical development2017
- Author(s)
  Bansod Shama、Kageyama Ryoichiro、Ohtsuka Toshiyuki
- Journal Title
  
  Development
  
  Volume: 144 Issue: 17 Pages: 3156-3167
- DOI
  10.1242/dev.147256
- NAID
  120006488607
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06480, KAKENHI-PROJECT-15K06773
[Journal Article] Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis.2016
- Author(s)
  Shimojo H, Isomura A, Ohtsuka T, Kori H, Miyachi H, Kageyama R
- Journal Title
  
  Genes Dev.
  
  Volume: 30 Issue: 1 Pages: 102-116
- DOI
  10.1101/gad.270785.115
- NAID
  120005980896
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06773, KAKENHI-PUBLICLY-26119708, KAKENHI-PROJECT-15H02349, KAKENHI-PROJECT-15H05326
[Journal Article] Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development.2015
- Author(s)
  Goto M, Hojo M, Ando M, Kita A, Kitagawa M, Ohtsuka T, Kageyama R, Miyamoto S
- Journal Title
  
  Brain Res
  
  Volume: 1625 Pages: 206-217
- DOI
  10.1016/j.brainres.2015.08.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06773, KAKENHI-PROJECT-23592121
[Journal Article] The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.2015
- Author(s)
  Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, Asano T, Yoshimi K, Zhang CL, Matsumoto G, Ohtsuka T, Kageyama R, Kiyonari H, Shioi G, Nukina N, Hattori N, Takahashi R
- Journal Title
  
  PLoS Genet.
  
  Volume: 11 Issue: 9 Pages: e1005503-e1005503
- DOI
  10.1371/journal.pgen.1005503
- NAID
  120005946994
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06773, KAKENHI-PROJECT-26860219, KAKENHI-PLANNED-23111002, KAKENHI-PUBLICLY-15H01561, KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26670442
[Journal Article] Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression.2015
- Author(s)
  Watanabe N, Kageyama R, Ohtsuka T
- Journal Title
  
  Development
  
  Volume: 142 Pages: 2278-2290
- DOI
  10.1242/dev.120477
- NAID
  120006488606
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06773, KAKENHI-PROJECT-15H02349
[Journal Article] Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene.2013
- Author(s)
  Harima Y, Takashima Y, Ueda Y, Ohtsuka T, Kageyama R.
- Journal Title
  
  Cell Rep.
  
  Volume: 3 Pages: 1-7
- NAID
  120005024759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500390
[Journal Article] Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development.2013
- Author(s)
  Kitagawa M, Hojo M, Imayoshi I, Goto M, Ando M, Ohtsuka T, Kageyama R, Miyamoto S.
- Journal Title
  
  Mech Dev.
  
  Volume: 130 Issue: 9-10 Pages: 458-66
- DOI
  10.1016/j.mod.2013.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500390
[Journal Article] Genetic visualization of notch signaling in mammalian neurogenesis.2013
- Author(s)
  Imayoshi I, Shimojo H, Sakamoto M, Ohtsuka T, Kageyama R
- Journal Title
  
  Cell Mol Life Sci.
  
  Volume: 70 Issue: 12 Pages: 2045-57
- DOI
  10.1007/s00018-012-1151-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500390, KAKENHI-PUBLICLY-24116705, KAKENHI-PROJECT-24700354
[Journal Article] Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development.2012
- Author(s)
  Tan SL, Nishi M, Ohtsuka T, Matsui T, Takemoto K, Kamio-Miura A, Aburatani H, Shinkai Y, Kageyama R.
- Journal Title
  
  Development
  
  Volume: 139 Pages: 3806-3816
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500390
[Journal Article] ヒストンメチルトランスフェラーゼESET は発生過程における神経前駆細胞のエピジェネティックな制御に必須である2012
- Author(s)
  Siok-Lay Tan, 西美幸, 大塚俊之, 他6名
- Journal Title
  
  Development
  
  Volume: 139(20) Pages: 3806-3816
- URL
  http://dev.biologists.org/content/139/20/3806.long
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500390
[Journal Article] 発生過程の脳においてmicroRNA9 はHes1 発現動態を調節することにより神経幹細胞の分化を制御する2012
- Author(s)
  Siok-Lay Tan, 大塚俊之, Aitor González, 影山龍一郎
- Journal Title
  
  Genes Cells
  
  Volume: 17(12) Issue: 12 Pages: 952-961
- DOI
  10.1111/gtc.12009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500390, KAKENHI-PROJECT-24240049, KAKENHI-PLANNED-22123002
[Journal Article] The identification of transcriptional targets of Ascl1 in oligodendrocyte development.2012
- Author(s)
  Ueno T, Ito J, Hoshikawa S, Ohori Y, Fujiwara S, Yamamoto S, Ohtsuka T, Kageyama R, Akai M, Nakamura K, Ogata T.
- Journal Title
  
  Glia
  
  Volume: 60 Pages: 1495-1505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500390
[Journal Article] The role of Hes genes in intestinal development, homeostasis and tumor formation.2012
- Author(s)
  Ueo T, Imayoshi I, Kobayashi T, Ohtsuka T, Seno H, Nakase H, Chiba T, Kageyama R
- Journal Title
  
  Development
  
  Volume: 139 Pages: 1071-1082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500390
[Journal Article] MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain.2012
- Author(s)
  Tan SL, Ohtsuka T, Gonzalez A, Kageyama R.
- Journal Title
  
  Genes Cells
  
  Volume: 17 Pages: 952-961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500390
[Journal Article] Continuous neurogenesis in the adult forebrain is required for innate olfactory responses.2011
- Author(s)
  Sakamoto M, Imayoshi I, Ohtsuka T, Yamaguchi M, Mori K, Kageyama R
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 108 Pages: 8479-8484
- NAID
  120003001324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500390
[Journal Article] Gene Expression Profiling of Neural Stem Cells and Identification of Regulators of Neural Differentiation During Cortical Development.2011
- Author(s)
  Ohtsuka T, Shimojo H, Matsunaga M, Watanabe N, Kometani K, Minato N, Kageyama R
- Journal Title
  
  Stem Cells
  
  Volume: 29 Pages: 1817-1828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500390
[Journal Article] Continuous neurogenesis in the adult forebrain is required for innate olfactory responses2011
- Author(s)
  M.Sakamoto, I.Imayoshi, T.Ohtsuka, M.Yamaguchi, K.Mori, R.Kageyama
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 108 Issue: 20 Pages: 8479-8484
- DOI
  10.1073/pnas.1018782108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04652, KAKENHI-PROJECT-21240028, KAKENHI-PLANNED-22123002, KAKENHI-PROJECT-23240046, KAKENHI-PROJECT-23500390
[Journal Article] Gene expression profiling of neural stem cells and identification of regulators of neural differentiation during cortical development2011
- Author(s)
  Ohtsuka, T., Shimojo, H., Matsunaga, M., Watanabe, N., Kometani, K., Minato, N., and Kageyama, R.
- Journal Title
  
  Stem Cells
  
  Volume: 29 Issue: 11 Pages: 1817-1828
- DOI
  10.1002/stem.731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240028, KAKENHI-PLANNED-22123002, KAKENHI-PROJECT-23500390
[Journal Article] Dynamic expression of notch signaling genes in neural stem/progenitor cells.2011
- Author(s)
  Shimojo H, Ohtsuka T, Kageyama R
- Journal Title
  
  Front Neurosci.
  
  Volume: 5 Pages: 78-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500390
[Journal Article] Continuous neurogenesis in the adult brain2009
- Author(s)
  Itaru Imayoshi, Masayuki Sakamoto, Toshiyuki Ohtsuka, Ryoichiro Kageyama
- Journal Title
  
  Dev. Growth Differ.
- NAID
  10025375872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610001
[Journal Article] Roles of Hes genes in neural development2008
- Author(s)
  Ryoichiro Kageyama, Toshiyuki Ohtsuka, Taeko Kobayashi
- Journal Title
  
  Dev. Growth Diff. 50 Suppl.
- NAID
  10024399396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610001
[Journal Article] Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline2008
- Author(s)
  Ryoichiro Kageyama, Toshiyuki Ohtsuka, Taeko Kobayashi
- Journal Title
  
  Development 135
  
  Pages: 2531-2541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610001
[Journal Article] Oscillations in notch signaling regulate maintenance of neural progenitors2008
- Author(s)
  Hiromi Shimojo, Toshiyuki Ohtsuka, Ryoichiro Kageyama
- Journal Title
  
  Neuron 58
  
  Pages: 52-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610001
[Journal Article] Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition2008
- Author(s)
  Ryoichiro Kageyama, Toshiyuki Ohtsuka, Hiromi Shimojo, Itaru Imayoshi
- Journal Title
  
  Nat. Neurosci. 11
  
  Pages: 1247-1251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610001
[Journal Article] Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells2008
- Author(s)
  Nakamura T, Ohtsuka T, Sekiyama T, Cooper LJ, Kokubu H, Fullwood XJ, Barrandon Y, Kageyama R, Kinoshita S
- Journal Title
  
  Stem cells 26
  
  Pages: 1265-1274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610001
[Journal Article] Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain2008
- Author(s)
  Imayoshi I, Sakamoto M, Ohtsuka T, Takao T, Mivakawa I, Yamaguchi M, Mori K, Ikeda T, Itohara S, Kageyama R
- Journal Title
  
  Nat. Neurosci. 11
  
  Pages: 1153-1161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610001
[Journal Article] Visualization of embryonic neural stem cells using Hes promoters in transgenic mice.2006
- Author(s)
  Toshiyuki Ohtsuka, Itaru Imayoshi, Hiromi Shimojo, Eiichiro Nishi, Ryoichiro Kageyama, Susan K.McConneil
- Journal Title
  
  Molecular and Cellular Neuroscience 31
  
  Pages: 109-122
- Data Source
  KAKENHI-PROJECT-16047219
[Journal Article] Visualization of embryonic neural stem cells using Hes promoters in transgenic mice2006
- Author(s)
  Toshiyuki Ohtsuka, Itaru Imayoshi, Hiromi Shimojo, Eiichiro Nishi, Ryoichiro Kageyama, Susan K. McConnell
- Journal Title
  
  Molecular and Cellular Neuroscience 31
  
  Pages: 109-122
- Data Source
  KAKENHI-PROJECT-16606002
[Journal Article] Visualization of embryonic neural stem cells using Hes promoters in transgenic mice2006
- Author(s)
  Toshiyuki Ohtsuka, Itaru Imayoshi, Hiromi Shimojo, Eiichiro Nishi, Ryoichiro Kageyama, Susan K.McConnell
- Journal Title
  
  Molecular and Cellular Neuroscience 31
  
  Pages: 109-122
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16606002
[Journal Article] Visualization of embryonic neural stem cells using Hespromoters in transgenic mice2006
- Author(s)
  Toshiyuki Ohtsuka, Itaru Imayoshi, Hiromi Shimojo, Eiichiro Nishi, Ryoichiro Kageyama, Susan K.McConnell
- Journal Title
  
  Molecular and Cellular Neuroscience 31
  
  Pages: 109-122
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16606002
[Presentation] Embryonic neural stem cells with high levels of Hes1 expression proliferate less frequently and remain as neural stem cells in the postnatal brain2018
- Author(s)
  大塚俊之
- Organizer
  新学術領域研究「脳構築における発生時計と場の連携」第３回領域班会議（ネオオリエンタルリゾート八ヶ岳高原、山梨県北杜市）
- Data Source
  KAKENHI-PROJECT-18K06253
[Presentation] Overexpression of Hes1 leads to prolonged neocortical neurogenesis and expansion of neural stem cell reservoir in postnatal brain2018
- Author(s)
  Toshiyuki Ohtsuka, Ryoichiro Kageyama
- Organizer
  ISDN 2018 (Nara, Japan)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06253
[Presentation] 神経幹細胞制御による脳形態形成の改変2018
- Author(s)
  大塚俊之、影山龍一郎
- Organizer
  神経発達・再生研究会（名古屋市立大学、名古屋）
- Data Source
  KAKENHI-PROJECT-18K06253
[Presentation] Overexpression of Hes1 leads to prolonged neocortical neurogenesis and expansion of neural stem cell reservoir in postnatal brain2018
- Author(s)
  Toshiyuki Ohtsuka, Ryoichiro Kageyama
- Organizer
  The CDB Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06773
[Presentation] Hes genes regulate the transition timing of neurogenesis and gliogenesis in neocortical development2017
- Author(s)
  大塚俊之
- Organizer
  新学術領域研究「脳構築における発生時計と場の連携」第２回領域班会議
- Data Source
  KAKENHI-PROJECT-15K06773
[Presentation] Hes5 regulates the transition timing of neurogenesis and gliogenesis in neocortical development via downregulation of Hmga genes2017
- Author(s)
  大塚俊之
- Organizer
  新学術領域「脳構築における発生時計と場の連携」第１回班会議
- Place of Presentation
  沼津ふじのくに千本松フォーラム
- Year and Date
  2017-01-27
- Data Source
  KAKENHI-PROJECT-15K06773
[Presentation] Hes5 regulates the transition timing of neurogenesis and gliogenesis in neocortical development via downregulation of Hmga genes2017
- Author(s)
  大塚俊之、Bansod Shama、影山龍一郎
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15K06773
[Presentation] 大脳皮質形成期においてHbp1は細胞周期の長さを延長することによってニューロン分化のタイミングを制御する2015
- Author(s)
  渡邊直希、影山龍一郎、大塚俊之
- Organizer
  第３８回　日本分子生物学会年会　第８８回　日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06773
[Presentation] Hes1強制発現により大脳皮質ニューロン産生が遷延し生後脳における神経幹細胞プールが増大する2015
- Author(s)
  大塚俊之、影山龍一郎
- Organizer
  第３８回　日本分子生物学会年会　第８８回　日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06773
[Presentation] Dynamic expression of Notch ligand Dll1 during development2015
- Author(s)
  Hiromi Shimojo, Hiroshi Kori, Akihiro Isomura, Toshiyuki Ohtsuka, Hitoshi Miyachi, Ryoichiro Kageyama
- Organizer
  第３８回　日本分子生物学会年会　第８８回　日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06773
[Presentation] Hes1 強制発現による大脳皮質ニューロン産生遅延および生後脳における神経幹細胞の増加2013
- Author(s)
  大塚俊之, 影山龍一郎
- Organizer
  第5回国際幹細胞学会
- Place of Presentation
  エルサレム, イスラエル
- Year and Date
  2013-10-08
- Data Source
  KAKENHI-PROJECT-23500390
[Presentation] 神経発生過程における遺伝子発現ダイナミクスによる神経分化制御機構の解明2013
- Author(s)
  下條博美, 播磨有希子, 前田勇樹, 大塚俊之, 他2名
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2013-12-13
- Data Source
  KAKENHI-PROJECT-23500390
[Presentation] 神経発生過程における遺伝子発現ダイナミクスによる神経分化制御機構の解明2013
- Author(s)
  下條博美、播磨有希子、前田勇樹、大塚俊之、宮地均、影山龍一郎
- Organizer
  第３６回　日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23500390
[Presentation] Overexpression of Hes1 Leads to Decelerated Timing of Cortical Neurogenesis and Expansion of Neural Stem Cell Reservoir in Postnatal Brain2013
- Author(s)
  Toshiyuki Ohtsuka, Ryoichiro Kageyama
- Organizer
  5th International Stem Cell Meeting
- Place of Presentation
  Jerusalem, Israel
- Data Source
  KAKENHI-PROJECT-23500390
[Presentation] 神経幹細胞における遺伝子発現プロファイルングおよび大脳皮質形成過程における神経分化制御因子の同定2011
- Author(s)
  大塚俊之, 他6名
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-23500390
[Presentation] 大脳新皮質発生における神経幹細胞の遺伝子発現プロファイリング2010
- Author(s)
  大塚俊之
- Organizer
  第17回東アジア医科学シンポジウム
- Place of Presentation
  台北、台湾
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-20610001
[Presentation] Gene expression profiling of neural stem cells during cortical development2010
- Author(s)
  Toshiyuki Ohtsuka
- Organizer
  The 17^<th> East Asia Joint Symposium on Biomedical Research
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-20610001
[Presentation] Satellite cells include stem cells in the spiral ganglion of the postnatal mouse inner ear2008
- Author(s)
  K. Kojima, T. Ohtsuka, T, Tateya, K, Ono, S. Takebayashi, R, Kageyama
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20591980
[Presentation] Satellite cells include stem cells in thespiral ganglion of the postnatal mouseinner ear2008
- Author(s)
  K. Kojima, T. Ohtsuka, T, Tateya, K, Ono, S. Takebayashi, R, Kageyama
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20591980
[Presentation] Gene expression profiling of neural stem cells and identification of regulators of neural differentiation during cortical development
- Author(s)
  大塚俊之、下條博美、松永充博、渡邊直希、米谷耕平、湊長博、影山龍一郎
- Organizer
  第３４回　日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23500390

1. KAGEYAMA Ryoichiro (80224369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. KOJIMA Ken (60378685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. IKEDA Katsuhisa (70159614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 別所康全 (70261253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 冨田江一 (80314285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 磯村彰宏 (70512466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHTSUKA Toshiyuki 大塚 俊之

OUTSUKA Toshiyuki 大塚 俊之

大塚 俊之 オオツカ トシユキ

Research Projects

Research Products

Co-Researchers

Physiological significance of ultradian oscillatory gene expression

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the mechanisms underlying mammalian brain development and evolutionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the mechanisms underlying the maintenance/differentiation of neural stem cells and brain development/evolution in mammalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanisms underlying the layer- and region-specificity during brain developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Visualizing and dynamic analysis of spiral ganglion cell progenitors b using of human hearing-loss model animals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the molecular mechanisms regulating the maintenance of multipotency and the dedifferentiation of neural stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経発生及び再生における幹細胞の可視化とニューロン・グリア産生機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Visualization of the neural stem cells and application to the regenerative medicinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular analysis for the novel two-hour cycle biological clocks Hes1 and Hes7

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経発生分化におけるbHLH型転写因子の役割の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 実験医学（増刊号）脳神経回路と高次脳機能 榎本和生、岡部繁男編2018

Author(s)

Publisher

Data Source

[Journal Article] Modification of gene expression and soluble factor secretion in the lateral ventricle choroid plexus: Analysis of the impacts on the neocortical development2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sonic hedgehog expands neural stem cells in the neocortical region leading to an expanded and wrinkled neocortical surface2021

Author(s)

Journal Title

DOI

Data Source

OHTSUKA Toshiyuki 大塚俊之

OUTSUKA Toshiyuki 大塚俊之

大塚俊之オオツカトシユキ

[Book] 実験医学（増刊号）脳神経回路と高次脳機能　榎本和生、岡部繁男編2018