AKITA Yukihiro 秋田幸大

… Alternative Names

秋田幸大アキタユキヒロ

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Researcher Number	20330821
Affiliation (Current)	2025: 久留米大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2008: 久留米大, 医学部, 助教 2007: KURUME UNIVERSITY, medical department, assistant 2004 – 2006: 久留米大学, 医学部, 助手 2001 – 2002: 久留米大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics Except Principal Investigator Pediatrics / Pediatrics
Keywords	Principal Investigator エネルギー全般 / ミトコンドリア / 遺伝子 / 老化 / プロセッシング / L-アルギニン / 血管内皮障害 / スクリーニング / 点変異 / ミトコンドリア病 … More Except Principal Investigator … More MELAS / 点変異 / energy crisis / ragged red fiber / respiratory chain enzyme defect / point mutation / mitohondrial gene / nuclear gene / mitochondrial myopathy / ミトコンドリア脳筋症 / ミトコンドリア脳菌 / エネルギー不全 / ragged-red fibers / 電子伝達系酵素欠損 / ミトコンドリア遺伝子 / 核遺伝子 / ミトコンドリア脳筋 / Klotho Knockout mouse / RNA19 / L-arginine / mitochondrial tRNA mutation / Mitochondrial disease / Nitric oxide / endothelial dyfunction / Mitochondrial stroke / L-アルギニン / ミトコンドリア病 / 一酸化窒素 / 血管内皮障害 / ミトコンドリア脳卒中 / 遺伝子相互作用 / A3243G変異 / 電子伝達系酵素活性 / 分子集合 / シナジー効果 / 核DNA / ミトコンドリアDNA Less

早期老化モデルマウスを用いたミトコンドリア機能障害の分子基盤解明Principal Investigator
- Principal Investigator
  
  秋田幸大
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
電子伝達系酵素アッセンブリーにおける核およびミトコンドリア多型のシナジー効果
- Principal Investigator
  
  KOGA Yasutoshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
早期老化モデルマウスを用いたエネルギー産生機能異常の分子基盤解明Principal Investigator
- Principal Investigator
  
  秋田幸大
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Analysis of mitochondria-nucleus inter-genetic network
- Principal Investigator
  
  KOGA Yasutoshi
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
ミトコンドリア異常症の新しい遺伝子異常発見のスクリーニングシステムの構築Principal Investigator
- Principal Investigator
  
  秋田幸大
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Molecular Basis of Mitochondrial Myopathy and Animal Models Related to the Energy Abnormality
- Principal Investigator
  
  KOGA Yasutoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  KURUME UNIVERSITY

All 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Inappropriate intracranial hemodynamics in the natural course of MELAS.2008
- Author(s)
  Nishioka J, Akita Y, Yatsuga S, Katayama K, Koga Y
- Journal Title
  
  Brain and Dev. 30
  
  Pages: 100-105
- NAID
  10025169185
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Journal Article] Effect of L-arginine on synaptosomal mitochondrial functio2008
- Author(s)
  Hirata K, Akita Y, Povalko N, Nishioka J, Yatsuga S, Matsuishi T, Koga Y
- Journal Title
  
  Brain and Dev. 30
  
  Pages: 238-245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Journal Article] MELAS and L-arginine therapy.2007
- Author(s)
  Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N,Katayama K, Matsuishi T
- Journal Title
  
  Mitochondrion 7
  
  Pages: 133-139
- NAID
  10027697233
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Journal Article] MELAS and L-arginine therapy.2007
- Author(s)
  Koga Y, Akita Y, 他5名
- Journal Title
  
  Mitochondrion 7(1-2)
  
  Pages: 133-139
- Data Source
  KAKENHI-PROJECT-17790733
[Journal Article] Mitochondrial tRNA gene mutation in patients having mitochondrial disease with lactic acidosis.2006
- Author(s)
  Ueki I, Akita Y, 他6名
- Journal Title
  
  Mitochondrion 6(1)
  
  Pages: 39-48
- Data Source
  KAKENHI-PROJECT-17790733
[Journal Article] Mitochondrial tRNA gene mutation in patients having mitochondrial disease with lactic acidosis.2006
- Author(s)
  Ueki I, Koga Y, Akita Y, 他5名
- Journal Title
  
  Mitochondrion 6(1)
  
  Pages: 39-48
- Data Source
  KAKENHI-PROJECT-17790733
[Journal Article] Endothelial dysfunction in MELAS was improved by L-arginine supplementation.2006
- Author(s)
  Koga Y, Akita Y, 他6名
- Journal Title
  
  Neurology 66(11)
  
  Pages: 1766-1769
- Data Source
  KAKENHI-PROJECT-17790733
[Journal Article] Mitochondrial tRNA gene mutations in patients having mitochondrial disease with lactic acidosis.2006
- Author(s)
  Ueki I, Koga Y, Povalko N, Akita Y, Nishioka J, Yatsuga S, Fukiyama R, Matsuishi T
- Journal Title
  
  Mitochondrion 6
  
  Pages: 39-48
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Journal Article] Endothelial dysfunction in MELAS was improved by L-arginine supplementation.2006
- Author(s)
  Koga Y, Akita Y, 他6名
- Journal Title
  
  Neurology In Press
- Data Source
  KAKENHI-PROJECT-17790733
[Journal Article] Endothelial dysfunction in MELAS was improved by L-arginine supplementation.2006
- Author(s)
  Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Fukiyama R, Ishii M, Matsuishi T
- Journal Title
  
  Neurology 66
  
  Pages: 1766-1769
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Journal Article] A new sequence variant in mitochondrial DNA associated with high penetrance of Russian Leber hereditary optic neuropathy.2005
- Author(s)
  Povalko N, Akita Y, 他5名
- Journal Title
  
  Mitochondrion 5(3)
  
  Pages: 194-199
- Data Source
  KAKENHI-PROJECT-17790733
[Journal Article] L-arginine improves the symptoms of stroke-like episodes in MELAS.2005
- Author(s)
  Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Tanabe Y, Fujimoto S, _Matsuis
- Journal Title
  
  Neurology 64
  
  Pages: 710-712
- Data Source
  KAKENHI-PROJECT-16390308
[Journal Article] Fujimoto S, Matsuishi T: L-arginine improves the symptoms of stroke? like episodes in MELAS.2005
- Author(s)
  Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Tanabe Y
- Journal Title
  
  Neurology 64(4)
  
  Pages: 710-712
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Journal Article] A new sequence variant in mitochondrial DNA associated with high penetrance of Russian Leber hereditary optic neuropathy.2005
- Author(s)
  Povalko N, Zakharova E, Rudenskaia G, Akita Y, Hirata K, Matsuishi T, Koga Y
- Journal Title
  
  Mitochondrion (in press)
- Data Source
  KAKENHI-PROJECT-16390308
[Journal Article] A new sequence variant in mitochondrial DNA associated with high penetrance of Russian Leber hereditary optic neuropathy.2005
- Author(s)
  Povalko N, Zakharova E, Rudenskaia G, Akita Y, Hirata K, Matsuishi T, Koga Y
- Journal Title
  
  Mitochondrion 5
  
  Pages: 194-199
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Presentation] L-arginine cure the stroke-like episodes in MELAS by Improving endothelial function.2007
- Author(s)
  Koga Y, Akita Y, Nishioka J, Yatsuga S, Katayama K, Matsuishi T, Povalko N.
- Organizer
  The 4th Annual Meeting of Asian Society for Mitochondrial Research and Medicine.
- Place of Presentation
  Seoul, Korea
- Year and Date
  2007-02-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Presentation] Study design in investigator-initiated phase III clinical trial of L-arginine on MELAS.2007
- Author(s)
  Koga Y, Akita Y, Nishioka J, Yatsuga S, Katayama K, Matsuishi T.
- Organizer
  11th Congress of the federation of neurological societies.
- Place of Presentation
  Brussels, Belgium
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Presentation] Incience and natural course of MELAS in Japan-Japanese cohort study-.2007
- Author(s)
  Koga Y, Yatsuga S, Akita Y, Nishioka J, Katayama K, Povalko N, Matsuishi T.
- Organizer
  48th annual meeting of the European society for pediatric research.
- Place of Presentation
  Prague, Czech
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Presentation] MELAS and L-arginine therapy.2006
- Author(s)
  Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Katayama K, Matsuishi T.
- Organizer
  Workshop sponsored by the Research Grant(17A-10) for Nervous and Mental Disorders. The Front Line of Therapy for Mitochondrial Myopathy
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2006-10-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Presentation] MELAS and L-arginine therapy.2006
- Author(s)
  Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N.
- Organizer
  11th International Congress on Neur omuscular Diseases.
- Place of Presentation
  Istanbul, Turkey
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Presentation] L-arginine therapy in MELAS.2005
- Author(s)
  Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Matsuishi T.
- Organizer
  18th World Congress of Neurology.
- Place of Presentation
  Sydney, Australia
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Presentation] A new sequence variant in mitochondrial DNA associated with high penetrance of Russian Leber hereditary optic neuropathy.2005
- Author(s)
  Povalko N, Zakharova E, Rudenskaia G, Akita Y, Hirata K, Matsuishi T, Koga Y.
- Organizer
  18th World Congress of Neurology.
- Place of Presentation
  Sydney, Australia
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Presentation] Entire mtDNA sequence analysis in Russian LHON family.2004
- Author(s)
  Povalko N, Zakharova E, Akita Y, Nishioka J, Koga Y.
- Organizer
  6th European Meeting on Mitochondrial Pathology.
- Place of Presentation
  Nijmegen, Holland
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308
[Presentation] MELAS and -arginine Therapy.2004
- Author(s)
  Koga Y, Akita Y, Nishioka J, Povalko N, Matsuishi T.
- Organizer
  6th European Meeting on Mitochondrial Pathology.
- Place of Presentation
  Nijmegen, Holland
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390308

1. KOGA Yasutoshi (00225400)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. NISHIOKA Jyunko (00449919)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
3. YATSUGA Shuichi (10454919)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
4. FUKIYAMA Ryo (40289434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. IWANAGA Rikako (20258396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HIRATA Koji (50360293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. MAJIMA Hideyuki (60165701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AKITA Yukihiro 秋田 幸大

秋田 幸大 アキタ ユキヒロ

Research Projects

Research Products

Co-Researchers

早期老化モデルマウスを用いたミトコンドリア機能障害の分子基盤解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

電子伝達系酵素アッセンブリーにおける核およびミトコンドリア多型のシナジー効果

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

早期老化モデルマウスを用いたエネルギー産生機能異常の分子基盤解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of mitochondria-nucleus inter-genetic network

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ミトコンドリア異常症の新しい遺伝子異常発見のスクリーニングシステムの構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Basis of Mitochondrial Myopathy and Animal Models Related to the Energy Abnormality

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inappropriate intracranial hemodynamics in the natural course of MELAS.2008

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Effect of L-arginine on synaptosomal mitochondrial functio2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] MELAS and L-arginine therapy.2007

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] MELAS and L-arginine therapy.2007

Author(s)

Journal Title

Data Source

[Journal Article] Mitochondrial tRNA gene mutation in patients having mitochondrial disease with lactic acidosis.2006

Author(s)

Journal Title

Data Source

[Journal Article] Mitochondrial tRNA gene mutation in patients having mitochondrial disease with lactic acidosis.2006

Author(s)

Journal Title

Data Source

[Journal Article] Endothelial dysfunction in MELAS was improved by L-arginine supplementation.2006

Author(s)

Journal Title

Data Source

[Journal Article] Mitochondrial tRNA gene mutations in patients having mitochondrial disease with lactic acidosis.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Endothelial dysfunction in MELAS was improved by L-arginine supplementation.2006

AKITA Yukihiro 秋田幸大

秋田幸大アキタユキヒロ