KUBO Hiroshi 久保裕司

Researcher Number	20332504
Other IDs	https://orcid.org/0000-0001-6097-4542
External Links
Affiliation (based on the past Project Information) *help	2015: 東北大学, 医学系研究科, 准教授 2011 – 2015: 東北大学, 医学(系)研究科(研究院), 准教授 2014: 東北大学, 医学系研究科, 研究員 2008 – 2012: Tohoku University, 大学院・医学系研究科, 准教授 2008 – 2009: 東北大学, 医学系研究科, 准教授 … More 2007: Tohoku University, 病院, 助教 2006: 東北大学, 病院・助手 2004 – 2006: Tohoku University, Hospital, Research Associate, 病院, 助手 2004: Tohoku University, Hospital, Research Associate, 病院・助手 2002 – 2003: Tohoku University Hospital, Research Associate, 医学部附属病院, 助手 2001: 東北大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine / Thoracic surgery
Keywords	Principal Investigator 呼吸器病学 / 再生医療 / 分化 / 細胞治療 / 遺伝子発現 / 幹細胞 / 組織幹細胞 / 培養細胞 / 老化 / COPD … More / 慢性閉塞性肺疾患 / 肺胞上皮細胞 / LPS / 肺気腫 / 肺胞 II 型上皮細胞 / 肺線維症 / 再生医療 / 肺胞II型上皮細胞 / 創薬 / 癌 / 海洋生物 / 薬剤反応性 / シグナル伝達 / 薬学 / マイクロアレイ / 薬理学 / トランスレーショナルリサーチ / 肺細胞 / エピジェネティクス / 血管内皮細胞 / 肺血管内皮細胞 / 喫煙 / 肺疾患 / 骨髄 / 炎症 / 再生 / 修復 / 前駆細胞 / 肺 / 肺炎 / 肺傷害 / 骨髄幹細胞 / 再生医学 / 好中 / bone marrow / inflammation / regeneration / repair / progenitor cell / lung / stem cell / 肺再生 / 骨髄由来幹細胞 / 増殖因子 / 肺胞上皮 / 肺毛細血管内皮 / regenerative medicine / lung regeneration / pulmonary emphysema / bone marrow-derived cells / stem cells / growth factors / alveolar epithelial cells / capillary endothelial cells / 移植・再生医療 / 呼吸器 / 組織修復 / Regenerative Medicine / Cell therapy / Respiratory Medicine / Pulmonary emphysema / Stem cell / Differentiation / Lung epithelial cell / Tissue repair / 内皮細胞 / 微小粒子 … More Except Principal Investigator 急性肺損傷 / 肺胞上皮細胞 / 好中球 / アポトーシス / 好中球エラスターゼ / プロテアーゼ受容体 / 組織修復 / ARDS / 肺移植 / 血管内皮前駆細胞 / インターロイキン-10 / GFPラット / 虚血・再灌流傷害 / 細胞移植 / 血管内皮前前駆細胞 / IL-10 / 組胞移植 / 組織固有幹細胞 / 肺癌 / サイトカイン / 血管新生 / 血管新生因子 / Lung Cancer / Cytokine / Angiogenesis Less

COPD-血管内皮微小粒子のin vivoイメージングPrincipal Investigator
- Principal Investigator
  
  久保裕司
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
難治性肺疾患における肺胞構成細胞機能解析Principal Investigator
- Principal Investigator
  
  久保裕司
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Identification of somatic stem cells in an alveolar epithelial cell population using a label-retaining strategy
- Principal Investigator
  
  YAMADA Mitsuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Mechanisms of an anti-cancer effect of a novel marine natural compound, exiguolide.Principal Investigator
- Principal Investigator
  
  KUBO Hiroshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Human alveolar epithelial progenitor cells revealed pathophysiological mechanisms of refractory pulmonary diseasesPrincipal Investigator
- Principal Investigator
  
  KUBO Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Iung repair by lung endogenous stem cellsPrincipal Investigator
- Principal Investigator
  
  KUBO Hiroshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Treatment for primary lung graft dysfunction by transfusion of endothelial progenitor cells transferred with intreleukin-10 gene.
- Principal Investigator
  
  OKADA Yoshinori
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Tohoku University
急性肺損傷の新規治療法の開発;PARの役割と治療への応用
- Principal Investigator
  
  鈴木朋子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Development of Regenerative Medicine for COPDPrincipal Investigator
- Principal Investigator
  
  KUBO Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Investigation of the role for novel angiogenic factor IL-17 in human non-small cell lung cancer-induced tumor angiogenesis
- Principal Investigator
  
  NUMASAKI Muneo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
The role on bone marrow-derived cells in lung repair and regeneration.Principal Investigator
- Principal Investigator
  
  KUBO Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  TOHOKU UNIVERSITY
An importance on bone marrow-derived cells on lung repairPrincipal Investigator
- Principal Investigator
  
  KUBO Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book Patent

[Book] Annual Review 呼吸器 20142014
- Author(s)
  久保裕司
- Total Pages
  273
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-25293190
[Book] 特集注目される呼吸器疾患の病態・診断・治療「急性肺傷害における肺胞上皮傷害と修復」呼吸器内科2013
- Author(s)
  久保裕司
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 一週一話:肺の再生医療-研究の現状と今後の展望.日本医事新報2012
- Author(s)
  久保裕司
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 特集呼吸器のサイエンス「肺血管再生医療の現状」.アンチ・エイジング医学(日本抗加齢医学会雑誌)2012
- Author(s)
  久保裕司
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 総説肺の stem cells.呼吸2012
- Author(s)
  久保裕司
- Publisher
  Respiration Research Foundation
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 高齢者の肺炎治療・リハビリテーション・予防2011
- Author(s)
  久保裕司
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 呼吸と循環.炎症損傷における組織幹細胞2011
- Author(s)
  久保裕司
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 特集COPD-生命予後の改善を目指して-:COPDの治療.非薬物療法.肺再生医療の現状と今後の展望.日本臨牀2011
- Author(s)
  久保裕司
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 特集急性肺損傷/急性呼吸窮迫症候群(ALI/ARDS):診断と治療の進歩.トピックスIV.最近の話題.3.急性肺損傷における細胞治療の可能性.日内会誌2011
- Author(s)
  久保裕司
- Publisher
  日本内科学会
- Data Source
  KAKENHI-PROJECT-22390163
[Book] ARDS-新しい治療標的. Annual Review 呼吸器2010
- Author(s)
  久保裕司
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 第80回閉塞性肺疾患研究会.「COPD 研究の最前線:基礎から臨床まで」幹細胞より見た COPD:肺再生へのアプローチ.呼吸2010
- Author(s)
  久保裕司
- Publisher
  Respiration Research Foundation
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 炎症損傷における組織幹細胞の関与.日本アレルギー学会誌2010
- Author(s)
  久保裕司
- Publisher
  日本アレルギー学会
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 喘息/COPD の基礎研究最前線. COPD における組織幹細胞の関与International Review of Asthma & COPD2010
- Author(s)
  久保裕司
- Publisher
  Medical Review社
- Data Source
  KAKENHI-PROJECT-22390163
[Book] ARDS up-to-date:ARDS治療へ向けた幹細胞研究の進歩Shock2010
- Author(s)
  久保裕司
- Publisher
  日本ショック学会
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 別冊・医学のあゆみ最新ARDSのすべて再生医療・細胞治療の可能性2010
- Author(s)
  久保裕司
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 肺のprogenitor cellについて.呼吸2010
- Author(s)
  久保裕司
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 最新医学別冊「新しい診断と治療のABC慢性閉塞性肺疾患改訂第2版」2010
- Author(s)
  久保裕司
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 老年医学の展望-肺の再生.老年医学update 2010-112010
- Author(s)
  久保裕司
- Publisher
  メディカルビュー社
- Data Source
  KAKENHI-PROJECT-22390163
[Book] 特集-肺再生医学-現状と将来-COPDにおける再生医学The LUNG Perspective2009
- Author(s)
  久保裕司
- Total Pages
  277
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 特集-肺再生医学-現状と将来-COPDにおける再生医学2009
- Author(s)
  久保裕司
- Publisher
  The LUNG Perspective
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 老年医学の展望肺の再生2009
- Author(s)
  久保裕司
- Publisher
  日老医誌
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 特集-「各臓器・組織における細胞・幹細胞移植の現状と可能性」肺における細胞治療の可能性(移植)2008
- Author(s)
  久保裕司
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 肺の再生と幹細胞(呼吸と循環)2008
- Author(s)
  久保裕司
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 肺損傷と修復のメカニズム. Annual Review 呼吸器2008
- Author(s)
  久保裕司
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 初学者に必要なARDS診療ノウハウ. 病態生理2008
- Author(s)
  久保裕司
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-19390222
[Book] Annual Review呼吸器2008. 肺損傷と修復のメカニズム2008
- Author(s)
  久保裕司
- Total Pages
  277
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 肺の修復と再生(呼吸)2008
- Author(s)
  久保裕司
- Data Source
  KAKENHI-PROJECT-19390222
[Book] Annual Review呼吸器2008:肺損傷と修復のメカニズム2008
- Author(s)
  久保裕司
- Total Pages
  277
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 日本老年医学会雑誌(肺胞の再生と治療への展望)2007
- Author(s)
  石沢興太, 久保裕司
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 特集 : ALI/ARDSの病態と治療. ALI/ARDSにおける肺の修復と再生(呼吸と循環)2007
- Author(s)
  久保裕司
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 特集 : 慢性閉塞性肺疾患-最近の動向-再生医療の展望(最新医学)2007
- Author(s)
  久保裕司
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 特集 : 慢性閉塞性肺疾患 (COPD)-最新の基礎・臨床研究-. 特論細胞治療の可能性(日本臨床)2007
- Author(s)
  久保裕司
- Data Source
  KAKENHI-PROJECT-19390222
[Book] 最新医学.肺損傷と修復の分子メカニズム.2006
- Author(s)
  久保裕司
- Total Pages
  14
- Publisher
  最新医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590774
[Book] 最新医学.肺損傷と修復の分子メカニズム.2006
- Author(s)
  久保裕司
- Total Pages
  14
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-17590774
[Book] 医学のあゆみ:ARDSの全て.再生医療の可能性.2004
- Author(s)
  久保裕司
- Total Pages
  370
- Publisher
  医歯薬出版株式会社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590792
[Book] 医学のあゆみ:ARDSの全て.再生医療の可能性2004
- Author(s)
  久保裕司
- Total Pages
  370
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-15590792
[Journal Article] Cyclin-dependent kinase-specific activity predicts the prognosis of stage I and stage II non-small cell lung cancer.2014
- Author(s)
  Kubo H, Suzuki T, Matsushima T, Ishihara H, Uchino K, Suzuki S, Tada S, Yoshimura M, Kondo T.
- Journal Title
  
  BMC Cancer
  
  Volume: 14 Pages: 755-755
- DOI
  10.1186/1471-2407-14-755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293190
[Journal Article] The role of microparticles in COPD.2014
- Author(s)
  Takahashi T and Kubo H.
- Journal Title
  
  Int J COPD
  
  Volume: 9 Pages: 30-314
- DOI
  10.2147/copd.s38931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293190
[Journal Article] c-Kit immunoexpression delineates a putative endothelial progenitor cell population in developing human lungs.2014
- Author(s)
  Suzuki T, Suzuki S, Fujino N, Ota C, Yamada M, Suzuki T, Yamaya M, Kondo T, Kubo H.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 印刷中
- DOI
  10.1152/ajplung.00211.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293190
[Journal Article] Pulmonary administration of Am80 regenerates collapsed alveoli.2014
- Author(s)
  Sakai H, Horiguchi M, Ozawa C, Akita T, Hirot K, Shudo K, Terada H, Makino K, Kubo H, Yamashita C.
- Journal Title
  
  J Control Release
  
  Volume: 196 Pages: 154-160
- DOI
  10.1016/j.jconrel.2014.10.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293190
[Journal Article] Annual FEV1 changes and numbers of circulating endothelial microparticles in COPD patients.2014
- Author(s)
  Takahashi T， Kobayashi S， Fujino N， Suzuki T， Ota C， Tando Y， Yamada M， Yanai M， Yamaya M， Kurosawa S， Yamauchi M， Kubo H
- Journal Title
  
  BMJ Open
  
  Volume: 4
- DOI
  10.1136/bmjopen-2013-004571
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592350, KAKENHI-PROJECT-25293190
[Journal Article] ulmonary administration of integrin-nanoparticles regenerates collapsed alveoli.2014
- Author(s)
  Horiguchi M, Kojima H, Sakai H, Kubo H, Yamashita C.
- Journal Title
  
  J Control Release
  
  Volume: 187 Pages: 167-174
- DOI
  10.1016/j.jconrel.2014.05.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293190
[Journal Article] Increased severity of H1N1 pandemic influenza virus infection in alveolar type II cells from patients with pulmonary fibrosis.2013
- Author(s)
  Fujino N, Kubo H, Ota C, Suzuki T, Takahashi T, Yamada M, Suzuki S, Kondo T, Nagatomi R, Tando Y, Yamaya M.
- Journal Title
  
  J Infect Dis
  
  Volume: 207 Pages: 692-693
- DOI
  10.1093/infdis/jis739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-24659398
[Journal Article] Differences in the released endothelial microparticle subtypes between human pulmonary microvascular endothelial cells and aortic endothelial cells in vitro.2013
- Author(s)
  Takahashi T, Kobayashi S, Fujino N, Suzuki T, Ota C, Tando Y, He M, Yamada M, Kurosawa S, Yamaya M, Kubo H
- Journal Title
  
  Exp Lung Res
  
  Volume: 39 Pages: 155-161
- DOI
  10.3109/01902148.2013.784932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-25293190
[Journal Article] The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells.2013
- Author(s)
  Mitsuhiro Yamada, Hiroshi Kubo, Chiharu Ota, Toru Takahashi, Yukiko Tando, Takaya Suzuki, Naoya Fujino, Tomonori Makiguchi, Kiyoshi Takagi, Takashi Suzuki, Masakazu Ichinose
- Journal Title
  
  Respir Res
  
  Volume: 14 Pages: 95-95
- DOI
  10.1186/1465-9921-14-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591148, KAKENHI-PROJECT-25293190
[Journal Article] Total Synthesis and Biological Evaluation of (－)-Exiguolide Analogues: Importance of the Macrocyclic Backbone.2013
- Author(s)
  Haruhiko Fuwa, Kana Mizunuma, Makoto Sasaki, Takaya Suzuki, Hiroshi Kubo
- Journal Title
  
  Organic & Bioorganic Chemistry
  
  Volume: 11 Pages: 3442-3450
- DOI
  10.1039/c3ob40131f
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23102016, KAKENHI-PROJECT-23659427, KAKENHI-PROJECT-23681045, KAKENHI-PROJECT-23890020, KAKENHI-PUBLICLY-24102507, KAKENHI-PROJECT-25282228
[Journal Article] 急性肺傷害における肺胞上皮傷害と修復2013
- Author(s)
  久保　裕司
- Journal Title
  
  呼吸器内科
  
  Volume: 23 Pages: 25-31
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Tissue engineering for pulmonary diseases-Insights from the laboratory2012
- Author(s)
  Kubo H
- Journal Title
  
  Respirology
  
  Volume: 17 Pages: 445-454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Clinical prospects for treating COPD with regenerative approaches2012
- Author(s)
  Kubo H.
- Journal Title
  
  Stem Cells Trans Med
  
  Volume: 1 Pages: 627-631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Analysis of gene expression profiles in alveolar epithelial type II-like cells differentiated from human alveolar epithelial progenitor cells.2012
- Author(s)
  Fujino N, Ota C, Suzuki T, Suzuki S, Hegab AE, Yamada M, Takahashi T, He M, Kondo T, Kato H, Yamaya M, Kubo H.
- Journal Title
  
  Resp Invest
  
  Volume: 50 Pages: 110-116
- DOI
  10.1016/j.resinv.2012.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Tissue engineering for pulmonary diseases – Insights from the laboratory.2012
- Author(s)
  Kubo H
- Journal Title
  
  Resprology
  
  Volume: 17 Pages: 445-454
- DOI
  10.1111/j.1440-1843.2012.02145.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Levofloxacin inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells2012
- Author(s)
  Yamaya M, Nishimura H, Hatachi Y, Yasuda H, Deng X, Sasaki T, Mizuta K, Kubo H, and Nagatomi R.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 56 Pages: 4052-4061
- DOI
  10.1128/aac.00259-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-24659398
[Journal Article] Surgical stress increases circulating endothelial microparticlesin the elderly2012
- Author(s)
  Takahashi T, Kubo H, Fujino N, Suzuki T, Ota C, Yamada M, Yamaya M, Suzuki S, Kurosawa S.
- Journal Title
  
  Anaesthesia & Intensive Care
  
  Volume: 40 Pages: 899-902
- URL
  http://www.aaic.net.au/document/?D=20120405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] 呼吸器のサイエンス「肺血管再生医療の現状」2012
- Author(s)
  久保　裕司
- Journal Title
  
  アンチ・エイジング医学（日本抗加齢医学会雑誌）
  
  Volume: 8 Pages: 555-560
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Increased circulating endothelial microparticles in COPDpatients: a potential biomarker for COPD exacerbation susceptibility2012
- Author(s)
  Takahashi T, Kobayashi S, Fujino N, Suzuki T, Ota C, He M, Yamada M, Suzuki S, Yanai M, Kurosawa S, Yamaya M, Kubo H.
- Journal Title
  
  Thorax
  
  Volume: 67 Pages: 1067-1074
- DOI
  10.1136/thoraxjnl-2011-201395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-22591702
[Journal Article] L-carbocisteine inhibits respiratory syncytial virus infection in human tracheal epithelial cells2012
- Author(s)
  Asada M, Yoshida M, Hatachi Y, Sasaki T, Yasuda H, Deng X, Nishimura H, Kubo H, Nagatomi R, Yamaya M.
- Journal Title
  
  Respir Physiol Neurobiol
  
  Volume: 180 Pages: 112-118
- DOI
  10.1016/j.resp.2011.10.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Gene expression profiles of alveolar type II cells of chronic obstructive pulmonary disease: A case-control study.2012
- Author(s)
  Fujino N, Ota C, Takahashi T, Suzuki T, Suzuki S, Yamada M, Nagatomi R, Kondo T, Yamaya M, Kubo H
- Journal Title
  
  BMJ Open
  
  Volume: 2
- DOI
  10.1136/bmjopen-2012-001553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-23890020, KAKENHI-PROJECT-24890016
[Journal Article] Repetetive pneumonia and wheezing in an elderly patient after radiation therapy2012
- Author(s)
  Yoshida M, Yamaya M, Asada M, Kubo H, Arai H.
- Journal Title
  
  Geriatr Gerontol Int
  
  Volume: 12 Pages: 352-353
- DOI
  10.1111/j.1447-0594.2011.00751.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Clinical prospects for treating COPD with regenerative approaches.2012
- Author(s)
  Kubo H.
- Journal Title
  
  Stem Cells Trans Med
  
  Volume: 17 Pages: 445-454
- DOI
  10.5966/sctm.2012-0065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] A novel method for isolating individual cellular components from the adult human distal lung2012
- Author(s)
  Fujino N, Kubo H, Ota C, Suzuki T, Suzuki S, Yamada M, Takahashi T, He M, Suzuki T, Kondo T, Yamaya M.
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 46 Pages: 422-430
- DOI
  10.1165/rcmb.2011-0172oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Inhibitory effects of tiotropium on rhinovirus infection in human airway epithelial cells2012
- Author(s)
  Yamaya M, Nishimura H, Hatachi Y, Yasuda H, Deng X, Sasaki T, Kubo H, and Nagatomi R
- Journal Title
  
  Eur Respir J
  
  Volume: 40 Pages: 122-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] p62/SQSTM1Accumulation is associated with poor prognosis of lung adenocarcinomapatients2012
- Author(s)
  Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S, Sugawara S, Watanabe M, Sakurada A, Endo C, Uruno A, Sasano H, Nakagawa T, Satoh K, Tanaka N, Kubo H, Motohashi H, Yamamoto M
- Journal Title
  
  Cancer Sci.
  
  Volume: 103 Pages: 760-6
- DOI
  10.1111/j.1349-7006.2012.02216.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-23592521, KAKENHI-PROJECT-23659166, KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24591184, KAKENHI-PROJECT-24592613, KAKENHI-PROJECT-24790306, KAKENHI-PLANNED-23116002
[Journal Article] 肺のstem cells2012
- Author(s)
  久保　裕司
- Journal Title
  
  呼吸
  
  Volume: 31 Pages: 1085-1092
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice2012
- Author(s)
  Fujino N, Kubo H, Suzuki T, He M, Suzuki T, Yamada M, Takahashi T, Ota C, Yamaya M.
- Journal Title
  
  Exp Lung Res
  
  Volume: 38 Pages: 28-36
- DOI
  10.3109/01902148.2011.633306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] RAGE binds phophatidylserine and mediates clearance of apoptotic cells2011
- Author(s)
  He M, Kubo H, Morimoto K, Fujino N, Suzuki T, Takahashi T, Yamada M, Yamaya M, Maekawa T, Yamamoto Y, Yamamoto H.
- Journal Title
  
  EMBO Rep
  
  Volume: 12 Pages: 358-364
- DOI
  10.1038/embor.2011.28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-23659430
[Journal Article] Surfactant protein C G100S mutation causes familial pulmonary fibrosis in Japanese kindred.2011
- Author(s)
  Ono S, Tanaka T, Ishida M, Kinoshita A, Fukuoka J, Takaki M, Sakamoto N,Ishimatsu Y, Kohno S, Hayashi T, Senba M, Yasunami M, Kubo Y, Yoshida LM, Kubo H, Ariyoshi K, Yoshiura K, Morimoto K.
- Journal Title
  
  Eur.Respir.J
  
  Volume: 38 Pages: 861-869
- DOI
  10.1183/09031936.00143610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-22590416, KAKENHI-PROJECT-22659071
[Journal Article] Molecular Basis of Lung Tissue Regeneration2011
- Author(s)
  Kubo H.
- Journal Title
  
  Gen Thorac Cardiovasc Surg
  
  Volume: 59 Pages: 231-244
- DOI
  10.1007/s11748-010-0757-x
- NAID
  10029018885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Impaired endothelial progenitor cell mobilization and colony-forming capacity in chronic obstructive pulmonary disease2011
- Author(s)
  Takahashi T, Suzuki S, Kubo H, Yamaya M, Kurosawa S, Kato M.
- Journal Title
  
  Respirology
  
  Volume: 16 Pages: 680-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Isolation of alveolar epithelial type II progenitor cells from adult human lungs2011
- Author(s)
  Fujino N, Kubo H, Suzuki T, Ota C, Hegab AE, He M, Suzuki S, Suzuki T, Yamada M, Kondo T, Kato H, Yamaya M.
- Journal Title
  
  Lab Invest
  
  Volume: 91 Pages: 363-378
- DOI
  10.1038/labinvest.2010.187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Inducible disruption of autophagy in the lung causes airway hyper-responsivenes2011
- Author(s)
  Inoue D, Kubo H, Taguchi K, Suzuki T, Komatsu M, Motohashi H, Yamamoto M
- Journal Title
  
  Biochem BiophysRes Commun
  
  Volume: 405 Pages: 13-18
- DOI
  10.1016/j.bbrc.2010.12.092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21591216, KAKENHI-PROJECT-22390163
[Journal Article] Evidence forHuman Lung Stem Cells2011
- Author(s)
  Suzuki T, Kondo T, Kubo H.
- Journal Title
  
  New Engl J Med
  
  Volume: 365 Pages: 464-466
- DOI
  10.1056/nejmc1106693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells2011
- Author(s)
  Yamaya M, Nishimura H, Hatachi Y, Yoshida M, Fujiwara H, Asada M, Nakayama K, Yasuds H, Deng X, Sasaki T, Kubo H, and Nagatomi R
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 650 Pages: 431-444
- DOI
  10.1016/j.ejphar.2010.09.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163
[Journal Article] The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury2011
- Author(s)
  Yamada M, Kitagawa M, Yano H, Tamamura H, Fujii N, Kaku M, et al.
- Journal Title
  
  Cellular & molecular immunology
  
  Volume: 8 Pages: 305-314
- DOI
  10.1038/cmi.2011.8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390029, KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-22659021, KAKENHI-PROJECT-22790745
[Journal Article] Isolation and characterization of murine multipotent lung stem cells2010
- Author(s)
  Hegab AE, Kubo H, Fujino N, Suzuki T, He M, Kato H, Yamaya M.
- Journal Title
  
  Stem Cells Dev 19
  
  Pages: 523-535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Preservation Solution for Endogenous Tisssue Stem Cells.2009
- Author(s)
  T.Suzuki, H.Kubo, N.Fujino, A.E.Hegab, M.He, Y.Okada, M.Yamaya, T.Kondo.
- Journal Title
  
  Am J Respir Crit Care Med 179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591608
[Journal Article] Impairment of swallowing in COPD2009
- Author(s)
  Kobayashi S, Kubo H, Yanai M.
- Journal Title
  
  Am J Respir Crit Care Med 180
  
  Pages: 481-481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Effects of pneumococcal vaccination on hospitalization and exacerbations in elderly Japanese chronic obstructive pulmonary disease patients2009
- Author(s)
  Yamaya M, Fujino N, Kubo H, Arai H.
- Journal Title
  
  Geriatr Gerontol Int 9
  
  Pages: 206-209
- NAID
  10025226913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Seizure and pneumonia in an elderly patients with systemic lupus erythematosus2009
- Author(s)
  Yamaya M, Yoshida M, Kubo H, Furukawa K.
- Journal Title
  
  Journal of the American Geriatrics Society 57
  
  Pages: 1709-1710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] CD117 positive cells without mast cell lineage are localized in the lung parenchyma and alveolar wall in adult human lungs.2009
- Author(s)
  T.Suzuki, H.Kubo, N.Fujino, A.E.Hegab, M.He, Y.Okada, M.Yamaya, T.Kondo
- Journal Title
  
  Am J Respir Crit Care Med 179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591608
[Journal Article] L-Carbocisteine reduces neutrophil elastase-induced mucin production2009
- Author(s)
  Yasuo M, Fujimoto K, Imamura H, Ushiki A, Kanda S, Tsushima K, Kubo H, Yamaya M, Kubo K.
- Journal Title
  
  Respir Physiol Neurobiol 167
  
  Pages: 214-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells2009
- Author(s)
  Asada M, Yoshida M, Suzuki T, Hatachi Y, Ssasaki T, Yasuda H, Nakayama K, Nishimura H, Nagatomi R, Kubo H, Yamaya M.
- Journal Title
  
  Antiviral Research 83
  
  Pages: 191-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells2009
- Author(s)
  Yoshida M, Nakayama K, Yasuda H, Kubo H, Kuwano K, Arai H, Yamaya M.
- Journal Title
  
  Respirology 14
  
  Pages: 1027-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Erythromycin attenuates MUC5AC synthesis and secretion in cultured human tracheal cells with RV14 infection2008
- Author(s)
  Inoue D, Kubo H, Sasaki T, Yasuda H, Numasaki M, Sasaki H, Yamaya M.
- Journal Title
  
  Respirology 13
  
  Pages: 215-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Intranasal HGF administration ameliorates the physiologic and morphologic changes in lung emphysema2008
- Author(s)
  Hegab AE, Kubo H, Yamaya M, Asada m, He M, Fujino N, Mizuno S, Nakamura T.
- Journal Title
  
  Molecular Therapy 16
  
  Pages: 1417-1426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Submucosal gland cells in human lower airways produce MUC5AC protein2008
- Author(s)
  Inoue D, Kubo H, Watanabe M, Sasaki T, Yasuda H, Numasaki M, Sasaki H, Yamaya M.
- Journal Title
  
  Respirology 13
  
  Pages: 285-287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Endogenous lung stem cells increased after lung injury2008
- Author(s)
  Kubo H, et.al.
- Journal Title
  
  Proc. AM. Thorac. Soc. 5
  
  Pages: 362-363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Endogenous lung stem cells increased after lung injury2008
- Author(s)
  Kubo H, Hegab AE, He M, Ishizawa K, Yamada M.
- Journal Title
  
  Proc Am Thorac Soc 5
  
  Pages: 362-363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Identification of Pendrin as a Common Mediator for Mucus Production in Bronchial Asthma and Chronic Obstructive Pulmonary Disease2008
- Author(s)
  Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, Sagara H, Sugiyama K, Tanaka H, Toda S, Hayashi H, Inoue H, Hoshino T, Shiraki A, Inoue M, Suzuki K, Aizawa H, Okinami S, Nagai H, Hasegawa M, Fukuda T, Green ED, Izuhara K.
- Journal Title
  
  J Immunol 180
  
  Pages: 6262-6269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] The role of the receptor for advanced glycation end-products in lung fibrosis2007
- Author(s)
  He M, Kubo H, Ishizawa K, Hegab AE, Yamamoto Y, Yamamoto H, Yamaya M.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice2007
- Author(s)
  Yanagi S, Kishimoto H, Kawahara K, Sasaki T, Sasaki M, Nishio M, Yajima N, Hamada K, Hori Y, Kubo H, Whitsett JA, Mak TW, Nakano T, Makazato M, Suzuki A.
- Journal Title
  
  J Clin Invest 117
  
  Pages: 2929-2940
- NAID
  120003728373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Impairment of the swallowing reflex in exacerbations of COPD2007
- Author(s)
  Kobayashi S, Kubo H, Yanai M.
- Journal Title
  
  Thorax 62
  
  Pages: 1017-1017
- NAID
  120003780210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390222
[Journal Article] Comment on "Cutting Edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury2006
- Author(s)
  Kubo H, et al.
- Journal Title
  
  J immunol 176
  
  Pages: 3856-3856
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590774
[Journal Article] Comment on "Cutting Edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury"2006
- Author(s)
  Kubo H, et. al.
- Journal Title
  
  Jimmunol 176
  
  Pages: 3856-3856
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590774
[Journal Article] Comment on "Cutting Edge : TLR4 deficiency confers susceptibility to lethal oxidant lung injury"2006
- Author(s)
  Kubo H, et al.
- Journal Title
  
  J immunol 176
  
  Pages: 3856-3856
- Data Source
  KAKENHI-PROJECT-17590774
[Journal Article] Is cell therapy in acute lung injury a realistic dream?2005
- Author(s)
  Kubo H, et al.
- Journal Title
  
  American Journal of Respiratory and Critical Care Medicine 172
  
  Pages: 794-795
- Data Source
  KAKENHI-PROJECT-17590774
[Journal Article] Anticoagulant therapy for idiopathic pulmonary fibrosis.2005
- Author(s)
  Kubo H, et al.
- Journal Title
  
  Chest 128
  
  Pages: 1475-1482
- Data Source
  KAKENHI-PROJECT-17590774
[Journal Article] Bone marrow-derived progenitor cells are important for lung repair after LPS-induced, lung injury.2004
- Author(s)
  Yamada M, Kubo H, Kobayashi S, et al.
- Journal Title
  
  J.Immunology 172
  
  Pages: 1266-1272
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590792
[Journal Article] Interferon-g : a key contributor to hyperoxia-induced lung injury in mice.2004
- Author(s)
  Yamada M, Kubo H.Kobayashi S, et al.
- Journal Title
  
  Am J Physiol : Lung Cell Mol Physiol 287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590792
[Journal Article] Effects of antiplatelet agents on pulmonary haemodynamic response to fMLP in endotoxin primed rats.2004
- Author(s)
  Song C, Suzuki S, Kubo H, et al.
- Journal Title
  
  Thorax 59
  
  Pages: 39-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590792
[Journal Article] Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cells.2004
- Author(s)
  Ishizawa K, Kubo H. Yamada M, et al.
- Journal Title
  
  Biochem Biophys Res Commun 324
  
  Pages: 276-280
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590792
[Journal Article] Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema.2004
- Author(s)
  Ishizawa K, Kubo H, Yamada M, et al.
- Journal Title
  
  FEBS Letter 556
  
  Pages: 249-252
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590792
[Patent] ヒト肺組織幹細胞の調製方法及び肺胞上皮細胞への分化誘導方法2009
- Inventor(s)
  久保裕司, 他
- Industrial Property Rights Holder
  東北テクノアーチ社
- Industrial Property Number
  2009-100548
- Filing Date
  2009-04-17
- Data Source
  KAKENHI-PROJECT-19390222
[Patent] ヒト肺組織幹細胞の調製方法及び肺胞上皮細胞への分化誘導方法2009
- Inventor(s)
  久保裕司, 藤野直也, 鈴木隆哉, 山谷睦雄
- Industrial Property Rights Holder
  東北テクノアーチ社
- Industrial Property Number
  2009-100548
- Acquisition Date
  2009-04-17
- Data Source
  KAKENHI-PROJECT-19390222
[Patent] 血管分化誘導促進剤2004
- Inventor(s)
  久保裕司
- Industrial Property Number
  2004-066415
- Filing Date
  2004-03-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590792
[Patent] 肺胞分化再生誘導剤2004
- Inventor(s)
  久保裕司
- Industrial Property Number
  2004-066410
- Filing Date
  2004-03-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590792
[Presentation] The increase of miR-21 in serum exosomes during human interstitial lung diseases2014
- Author(s)
  山田充啓、久保裕司、牧口友紀、小林誠一、矢内　勝、一ノ瀬正和
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  大阪市
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-24591148
[Presentation] 肺胞 II 型上皮細胞および肺胞上皮幹細胞の解析2014
- Author(s)
  久保裕司
- Organizer
  日本肺サーファクタント・界面医学会　第50回記念学術研究会
- Place of Presentation
  マリオス（盛岡市）
- Year and Date
  2014-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-25293190
[Presentation] Alveolar epithelial type II cell specific epigenetic modifications in idiopathic pulmonary fibrosis.2013
- Author(s)
  Ota C, Fujino N, Yamada M, Tando Y, Motohashi H, Suzuki T, Takahashi T, Suzuki S, Kondo T, Kato H, Yamaya M, Kubo H.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-25293190
[Presentation] Stem cells in lung biology and pulmonary diseases.2013
- Author(s)
  Kubo H.
- Organizer
  International Symposium: Anatomical Science for advance in health and clinical therapy.
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-25293190
[Presentation] Identification and characteristics of lung alveolar epithelial label-retaining cells2013
- Author(s)
  Mitsuhiro Yamada, Hiroshi Kubo, Naoya Fujino, Toru Takahashi, Chiharu Ota, Takaya Suzuki, Yukiko Tando, Masakazu Ichinose
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-24591148
[Presentation] Relationships Between Annual Changes In FEV1 And Numbers Of Circulating Endothelial Microparticles In COPD Patients.2013
- Author(s)
  Takahashi T Kobayashi S, Fujino N, Suzuki T, Tando Y, Ota C, Yamada M, Kurosawa S, Yanai M, Yamaya M, Kubo H.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-25293190
[Presentation] 学術講演：再生医療の肺への応用2013
- Author(s)
  久保　裕司
- Organizer
  第105回ACCP日本部会定期教育講演会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25293190
[Presentation] Tulobuterol Inhibits Rhinovirus Infection In Human Airway Epithelial Cells2012
- Author(s)
  Yamaya M, Hatachi Y, Kubo H, and Nishimura H.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  サンフランシスコ,米国
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] 特別講演:肺胞の破壊と再構築 -肺胞構成細胞の変化2012
- Author(s)
  久保裕司
- Organizer
  第21回 Kinki Chest Club
- Place of Presentation
  大阪
- Year and Date
  2012-10-27
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] Formoterol And Budesonide Inhibit Rhinovirus Infection In Human Airway Epithelial Cells2012
- Author(s)
  Yamaya M, Hatachi Y, Kubo H, and Nishimura H.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  サンフランシスコ,米国
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] International Symposium 4: Mechanisms of lung injury and repair. Lung injury and repair -the role of the receptor for advanced glycation end-products (RAGE)2012
- Author(s)
  久保裕司
- Organizer
  第52回日本呼吸器学会学術講演会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] 特別講演:急性肺損傷:修復のメカニズム2012
- Author(s)
  久保裕司
- Organizer
  第11回福岡肺分子病態研究会
- Place of Presentation
  福岡
- Year and Date
  2012-01-08
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] 特別講演:呼吸器病学への再生医療の応用2012
- Author(s)
  久保裕司
- Organizer
  第2回長崎呼吸器疾患と移植再生フォーラム
- Place of Presentation
  長崎
- Year and Date
  2012-04-05
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] Gene Expression Profiles Of Alveolar Type II Cells From COPD Patients2012
- Author(s)
  Fujino N, Ota C, Suzuki T, Suzuki S, Yamada M, Takahashi T, He M, Kondo T,Yamaya M, and Kubo H.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  サンフランシスコ,米国
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] 特別講演:急性肺損傷における組織修復2012
- Author(s)
  久保裕司
- Organizer
  第22回日本集中治療医学会九州地方会
- Place of Presentation
  鹿児島
- Year and Date
  2012-07-14
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] An Anti-Cancer Effect Of Newly Synthesized Marine Macrolide, (-)-Exiguolide2012
- Author(s)
  Suzuki T, Kubo H, Yamada M, Fuwa H, Fujino N, Takahashi T, Ota C, Yamaya M, and Kondo T
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  米国
- Year and Date
  2012-05-22
- Data Source
  KAKENHI-PROJECT-23659427
[Presentation] L-Carbocisteine InhibitsRespiratory Syncytial Virus Infection In Human Airway Epithelial Cells2012
- Author(s)
  Yamaya M, Hatachi Y, Kubo H, andNishimura H.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  サンフランシスコ,米国
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] Number Of Circulating Endothelial Microparticles Are Increased During Acute Exacerbation Of COPD; Potential Biomarkers For Progression Of Exacerbation2012
- Author(s)
  Takahashi T, Kobayashi S, Fujino N, Suzuki T, Ota C, Yamada M, He M, Kurosawa S, Yamaya M, and Kubo H.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  サンフランシスコ,米国
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] Supplementation Of MiR-200c Or Inhibition Of MiR-21Attenuates TGF-ss-InducedEpithelial-Mesenchymal Transition In Mouse Alveolar Type II Cells2012
- Author(s)
  Yamada M, Kubo H, Fujino N, Ota C, SuzukiT, Takahashi T, Kunishima H, Aoyagi T, Yamaya M, and Kaku M.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  サンフランシスコ,米国
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] Deacetylase Inhibitor Restores The Gene Expression Of Human Lung Surfactant Protein C DuringEpithelial-Mesenchymal Transition in vitro2012
- Author(s)
  Ota C, Fujino N, Yamada M, Motohashi H, Kato H, Yamaya M, and Kubo H. Histone
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  サンフランシスコ,米国
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] An anti-cancer effect of newly synthesized macrolide compounds2011
- Author(s)
  Suzuki T, Kubo H, Fuwa H, Kondo T
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  米国
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-23659427
[Presentation] Concurrent Symposia: Cell and Molecular Biology. Roles of Stem Cells in the Lung2011
- Author(s)
  Kubo H
- Organizer
  The 16th Congress of the APSR
- Place of Presentation
  上海,中国
- Year and Date
  2011-11-06
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] 「細胞から見た呼吸器病学」のはじまり2011
- Author(s)
  久保裕司
- Organizer
  Meet the Specialist -呼吸器疾患の診断と治療-
- Place of Presentation
  東京
- Year and Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] Expression patterns of two important regulatory microRNAs inepithelial-mesenchymal transition during experimental bleomycin-induced lung fibrosis2011
- Author(s)
  Yamada M, Kubo H, Fujino N, He M, Suzuki T, Takahashi T, Ota C, Aoyagi T, Kunishima H, Yamaya M, Kaku M.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  デンバー,米国
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] A newflow-cytometric method for isolating component cells individually from adult human distal lungs2011
- Author(s)
  Fujino N, Ota C, Suzuki T, He M, Takahashi T, Yamada M, Suzuki S, Kondo T, Yamaya M, Kubo H.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  デンバー,米国
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] 特別講演:肺再生研究の現状2011
- Author(s)
  久保裕司
- Organizer
  Respiratory Symposium in 札幌
- Place of Presentation
  札幌
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] A novel differentiation assay system for human alveolar epithelialtype ii cells from alveolar epithelial stem/progenitor cells in vitro2011
- Author(s)
  Ota C, Fujino N, Suzuki T, He M, Suzuki S, Yamada M, Kondo T, Kato H, Yamaya M, Kubo H.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  デンバー,米国
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] 特別講演:肺再生医療について-これからの呼吸器病学2011
- Author(s)
  久保裕司
- Organizer
  第5回神奈川COPD先端治療研究会
- Place of Presentation
  横浜
- Year and Date
  2011-07-07
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] Circulating endothelial microparticles are increased in patients with COPD; a potential novel biomarker for COPD2011
- Author(s)
  Takahashi T, Suzuki S, Kobayashi S, HeM, Suzuki T, Fujino N, Ota C, Kurosawa S, Kato M, Yamaya M, Kubo H.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  デンバー,米国
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] Endogenous progenitor cells in adult human lungs2011
- Author(s)
  Kubo H, Fujino N, Suzuki T, Ota C, He M, Yamada M, Yamaya M.
- Organizer
  15th Congress of the Asian Pacific Society of Respirology
- Place of Presentation
  マニラ,フィリピン
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] 急性肺損傷-個別化医療・細胞治療の可能性2011
- Author(s)
  久保裕司
- Organizer
  第32回日本呼吸器学会生涯教育講演会
- Place of Presentation
  東京
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] 難治性肺疾患に対する肺再生・修復治療の開発をめざして2010
- Author(s)
  久保裕司
- Organizer
  第12回東海分子呼吸器研究会
- Place of Presentation
  名古屋
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] 肺再生の可能性2010
- Author(s)
  久保裕司
- Organizer
  第9回 Organ Microcirculation Forum
- Place of Presentation
  東京
- Year and Date
  2010-01-14
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] ミニシンポジウム. 幹細胞より見たCOPD-肺再生へのアプローチ2010
- Author(s)
  久保裕司
- Organizer
  第80回閉塞性肺疾患研究会 (第100回肺気腫研究会)
- Place of Presentation
  東京
- Year and Date
  2010-01-23
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] 特別講演:肺の損傷と修復-肺胞に幹細胞は存在するか?2010
- Author(s)
  久保裕司
- Organizer
  第3回九州胸部疾患研究グループ(KREST-SG)の会
- Place of Presentation
  大分
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-22390163
[Presentation] Preservation Solution for Endogenous Tisssue Stem Cells2009
- Author(s)
  Suzuki T, Kubo H, Fujino N, Hegab AE, He M, Okada Y, Yamaya M, Kondo T.
- Organizer
  Am J Respir Crit Care Med 179 : 1997. American Thoracic Society
- Place of Presentation
  San Francisco
- Year and Date
  2009-05-18
- Data Source
  KAKENHI-PROJECT-19591608
[Presentation] 教育セミナー肺修復と肺胞II型上皮前駆細胞2009
- Author(s)
  久保裕司
- Organizer
  第63回呼吸器合同北陸地方会
- Place of Presentation
  富山
- Year and Date
  2009-11-08
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] 肺損傷と修復のダイナミズム. 肺損傷と修復における組織幹細胞の関与2009
- Author(s)
  久保裕司
- Organizer
  第7回肺研究フォーラム21
- Place of Presentation
  東京
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] New Preservation Solution for Endogenous Tissue Stem Cells2009
- Author(s)
  Suzuki T, Kubo H, et al.
- Organizer
  Am J Respir Crit Care Med.
- Place of Presentation
  ATS International Conference, San Diego, USA
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] CD117 Positive Cells without Mast Cell Lineage Are Localized in the Lung Parenchyma and Alveolar Wall in Adult Human Lungs2009
- Author(s)
  Suzuki T, Kubo H, et al.
- Organizer
  Am J Respir Crit Care Med.
- Place of Presentation
  ATS International Conference, San Diego, USA
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] 炎症損傷における組織幹細胞の関与2009
- Author(s)
  久保裕司
- Organizer
  第59回日本アレルギー学会秋期学術大会
- Place of Presentation
  秋田
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] Mesenchymal Stem Cells with Alveolar Epithelial Phenotype Were Isolated from Adult Human Lungs2009
- Author(s)
  Fujino N, Kubo H.
- Organizer
  Am J Respir Crit Care Med.
- Place of Presentation
  ATS International Conference, San Diego, USA
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] 肺再生医療への挑戦2009
- Author(s)
  久保裕司
- Organizer
  「学都仙台コンソーシアム」サテライトキャンパス公開講座
- Place of Presentation
  仙台
- Year and Date
  2009-12-19
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] 肺胞の再生と治療への展望2008
- Author(s)
  久保裕司
- Organizer
  第60回日本呼吸器学会九州地方会
- Place of Presentation
  宮崎
- Year and Date
  2008-04-26
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] Role of Neutrophil Elastase In the Repair Phase of Acute Lung Injury2008
- Author(s)
  Fujino N, Kubo H, et al.
- Organizer
  Am J Respir Crit Care Med.
- Place of Presentation
  ATS International Conference, Toronto, Canada
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] COPD2008
- Author(s)
  久保裕司
- Organizer
  第28回六甲カンファランス
- Place of Presentation
  神戸
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] 肺病変の修復と再生へのアプローチ2008
- Author(s)
  久保裕司
- Organizer
  第38回北陸呼吸器シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2008-02-01
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] 肺損傷と修復メカニズムの解明を元にしたトランスレーショナルリサーチへの展開2008
- Author(s)
  久保裕司
- Organizer
  第9回武蔵呼吸カンファランス
- Place of Presentation
  大宮
- Year and Date
  2008-01-19
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] Hyperoxia induces Toll-like receptor 4 upregulation on both hematopoietic and lung parenchymal cells2008
- Author(s)
  Kubo H, et al.
- Organizer
  Am J Respir Crit Care Med.
- Place of Presentation
  ATS International Conference, Toronto, Canada
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] Hyperoxia induces Toll-like receptor 4 upregulation on both hematopoietic and lung parenchymal cells2008
- Author(s)
  Kubo H, et.al.
- Organizer
  American Thoracic Soiety International Conference
- Place of Presentation
  トロント,カナダ
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] シンポジウム肺血管損傷と修復機構. ARDSにおける肺血管修復2008
- Author(s)
  久保裕司
- Organizer
  第48回日本呼吸器学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] Endogenous lung stem cells increased after lung injury.2007
- Author(s)
  Kubo H
- Organizer
  Thomas L. Petty Aspen Lung Conference, 50th Annual Meeting
- Place of Presentation
  アスペン,コロラド,USA
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] COPDにおける肺の修復と再生2007
- Author(s)
  久保裕司
- Organizer
  第6回山形COPD研究会
- Place of Presentation
  山形
- Year and Date
  2007-06-01
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] 喘息とCOPD-類似点と相違点-2007
- Author(s)
  久保裕司
- Organizer
  第35回箱根呼吸討論会
- Place of Presentation
  福岡
- Year and Date
  2007-06-16
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] Regeneration of ARDS lungs. (Congress of the APSR)2007
- Author(s)
  Kubo H.
- Organizer
  12th Concurrent Symposia : Critical Care. ARDS : Basic and Clinical Science
- Place of Presentation
  Queensland, Australia
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] Endogenous lung stem cells increased after lung injury2007
- Author(s)
  Kubo H.
- Organizer
  Aspen Lung Conference
- Place of Presentation
  Aspen, USA
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] 肺における細胞治療の可能性2007
- Author(s)
  久保裕司
- Organizer
  移植遺伝子工学シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2007-11-23
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] 肺の老化2007
- Author(s)
  久保裕司
- Organizer
  第13回東北老年医療シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2007-09-22
- Data Source
  KAKENHI-PROJECT-19390222
[Presentation] The Receptor For Advanced Glycation End-Products Of Alveolar Epithelial Cells Is A Key Modulator Of Hyperoxia-Induced Lung Injury
- Author(s)
  Ota C, Ishizawa K, Yamada M, Tando Y, He M, Takahashi T, Yamaya M, Yamamoto Y, Yamamoto H, Kubo H.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-05-17 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-25293190
[Presentation] COPD増悪と内皮細胞
- Author(s)
  Kubo H.
- Organizer
  The 2nd Tongji Respiratory Forum
- Place of Presentation
  上海，中国
- Year and Date
  2014-07-11 – 2014-07-12
- Invited
- Data Source
  KAKENHI-PROJECT-25293190
[Presentation] AXL receptor tyrosine kinase inhibition drives epithelial differentiation of human lung progenitor cells.
- Author(s)
  Fujino N, Kubo H, Maciewicz R.
- Organizer
  James Black meeting: Inspired Biologics (British Pharmacological Society)
- Place of Presentation
  Cambridge, UK
- Year and Date
  2014-09-18 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-25293190

1. KATO Hidemasa (50292123)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
2. OKADA Yoshinori (90323104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. SADO Tetsu (20396485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. HOSHIKAWA Yasushi (90333814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KONDO Takashi (10195901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. YAMADA Mitsuhiro (00396483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. NUMASAKI Muneo (50344677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUZUKI Takashi (10261629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 鈴木朋子 (10400342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松村輔二 (80281997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 不破春彦 (90359638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. SUZUKI Takaya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. FUJINO Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. YAMAUCHI Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. SUZUKI Norio

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. SUZUKI Takafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. TAGUCHI Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 山本博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 久保嘉直

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 山谷睦雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 西村秀一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 黒澤伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 佐々木誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 本橋ほづみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 田中伸幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 宇留野晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 玉村啓和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUBO Hiroshi 久保 裕司

Research Projects

Research Products

Co-Researchers

COPD-血管内皮微小粒子のin vivoイメージングPrincipal Investigator

Principal Investigator

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難治性肺疾患における肺胞構成細胞機能解析Principal Investigator

Principal Investigator

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Research Institution

Identification of somatic stem cells in an alveolar epithelial cell population using a label-retaining strategy

Principal Investigator

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Mechanisms of an anti-cancer effect of a novel marine natural compound, exiguolide.Principal Investigator

Principal Investigator

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Research Institution

Human alveolar epithelial progenitor cells revealed pathophysiological mechanisms of refractory pulmonary diseasesPrincipal Investigator

Principal Investigator

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Iung repair by lung endogenous stem cellsPrincipal Investigator

Principal Investigator

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Research Institution

Treatment for primary lung graft dysfunction by transfusion of endothelial progenitor cells transferred with intreleukin-10 gene.

Principal Investigator

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Research Institution

急性肺損傷の新規治療法の開発;PARの役割と治療への応用

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Development of Regenerative Medicine for COPDPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Investigation of the role for novel angiogenic factor IL-17 in human non-small cell lung cancer-induced tumor angiogenesis

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

The role on bone marrow-derived cells in lung repair and regeneration.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

An importance on bone marrow-derived cells on lung repairPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

[Book] Annual Review 呼吸器 20142014

Author(s)

Total Pages

Publisher

KUBO Hiroshi 久保裕司

[Book] 一週一話:肺の再生医療-研究の現状と今後の展望.日本医事新報2012

[Book] 総説肺の stem cells.呼吸2012

[Book] 第80回閉塞性肺疾患研究会.「COPD 研究の最前線:基礎から臨床まで」幹細胞より見た COPD:肺再生へのアプローチ.呼吸2010