Morimura Toshifumi 守村敏史

… Alternative Names

MORIMURA Toshifumi 守村敏史

守村敏史モリムラトシフミ

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Researcher Number	20333338
Other IDs
Affiliation (Current)	2025: 滋賀医科大学, 動物生命科学研究センター, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 滋賀医科大学, 動物生命科学研究センター, 准教授 2015 – 2019: 滋賀医科大学, 神経難病研究センター, 助教 2015: 滋賀医科大学, 学内共同利用施設等, 助教 2012 – 2014: 滋賀医科大学, 分子神経科学研究センター, 助教 2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第二部, 流動研究員 … More 2010: The Institute of Physical and Chemical Research, 神経研究所疾病研究第二部, 流動研究員 2009 – 2010: National Center of Neurology and Psychiatry, 神経研究所・疾病研究第二部, 流動研究員 2008: The Institute of Physical and Chemical Research, 小川研究ユニット, 研究員 2007: The Institute of Physical and Chemical Research, 細胞培養技術開発チーム, 研究員 2006: 独立行政法人理化学研究所, 細胞培養技術肺発チーム, 研究員 2003 – 2004: 独立行政法人理化学研究所, 細胞培養技術開発チーム, 研究員 Less
Review Section/Research Field	Principal Investigator Basic veterinary science/Basic zootechnical science / Basic Section 42020:Veterinary medical science-related / Veterinary medical science Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 56010:Neurosurgery-related / Basic Section 55050:Anesthesiology-related / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator ALS / 小胞体ストレス / オートファジー / チロシンリン酸化 / in utero electroporation / Srcファミリーチロシンキナーゼ / Reelin / Dab1 / TDP-43 / ユビキチン … More / SOD1 / ミスフォールド蛋白質 / 転写因子 / 大脳皮質 / endocytosis / カニクイザル / caspase 3 / 低分子化合物 / protein folding / 食品機能性成分 / ミスフォールディング / 分子プローブ / 発光プローブ / ポリフェノール / 発光タンパク質 / diosmetin / ミスフォールドタンパク質 / 小胞体 / ホタルルシフェラーゼ / プロテアソーム / S409/S410リン酸化 / 不溶性蛋白質 / CTF-25 / VHL / 細胞質凝集体 / ノックダウン / 筋萎縮性側索硬化症（ALS） / 孤発性ALS / 子宮内エレクトロポレーション / 筋萎縮性側索硬化症(ALS) / リン酸化 / 神経変性疾患 / 酸化 / autophagy / 食品成分 / チロシンリン酸 / Srcファミイーチロシンキナーゼ / Dabl / migration / 放射状移動 / 投射ニューロン / 核移行 / nucleocytoplasmic shuttling / ニューロン / PTBドメイン / 新規Dab1結合タンパク質 / 細胞内輸送 / Reelin受容体 … More Except Principal Investigator 筋萎縮性側索硬化症 / ノックインマウス / 変異遺伝子スクリーニング / Fused in sarcoma (FUS) / 低分子スクリーニング / RNA / DHX30 / FUS / 動物モデル / 脳動脈瘤 / kidney / endothelium / cerebral aneurysm / PKD / GCH1 / pChAT / Pain / serotonin / acetylcholine / peripheral ChAT / scFv / immunotherapy / 3D imaging / amyloid beta / conformational antibody / BH4 / GTP cyclohydrolase 1 / intrabody / scfv / antibody / tetrahyrobiopterin / GTP Cyclohydrolase 1 / 治療 / モデルマウス / プローブ / 先制医療 / エピトープ / 抗体 / TDP-43 / シグナル伝達 / 蛋白質 / 脳神経疾患 / 蛋白質分解 / 抗体医療 / 神経変性疾患 / ミスフォールドプロテイン / 筋萎縮性側索硬化症（ALS) Less

Pathological and diagnostic significance of the N-terminal fragment of TDP-43 in ALSPrincipal Investigator
- Principal Investigator
  
  守村敏史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Shiga University of Medical Science
PKD遺伝子異常に伴う脳動脈瘤発生の病態解明
- Principal Investigator
  
  野崎和彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Shiga University of Medical Science
新規ミトコンドリア蛋白質の構造異常によるALS病態の解析と評価モデル系の開発
- Principal Investigator
  
  漆谷真
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
Drug discovery against ER stress by using a novel luminescence probe sensing ER environmentsPrincipal Investigator
- Principal Investigator
  
  Morimura Toshifumi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Shiga University of Medical Science
Evaluation of an immunotherapy for chronic pain by expressing a single domain intrabody against the pain marker GCH1 in the rat dorsal root ganglion neurons
- Principal Investigator
  
  Bellier Jean-Pierre
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Shiga University of Medical Science
Pathological and therapeutic research of sporadic ALSPrincipal Investigator
- Principal Investigator
  
  Morimura Toshifumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  Shiga University of Medical Science
Development of a novel molecular targeting therapy and probe, using antibodies against pathogenic epitopes in TDP-43
- Principal Investigator
  
  Makoto Urushitani
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
  Kyoto University
Analysis of ALS related gene products in the mouse central nerve systemPrincipal Investigator
- Principal Investigator
  
  Toshifumi Morimura
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  Shiga University of Medical Science
Clinical application of autophagy-inducing factors from food supplementsPrincipal Investigator
- Principal Investigator
  
  MORIMURA Toshifumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Shiga University of Medical Science
  National Center of Neurology and Psychiatry
Functional analysis of Dab1as a transcription factor for transmission of Reelin signalingPrincipal Investigator
- Principal Investigator
  
  MORIMURA Toshifumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The Institute of Physical and Chemical Research
細胞内アダプター蛋白質Dab1によるニューロンの位置決定機構の解析Principal Investigator
- Principal Investigator
  
  守村敏史
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The Institute of Physical and Chemical Research
大脳皮質の構築に必須なアダプター蛋白質Dab1及びその結合蛋白質の機能解析Principal Investigator
- Principal Investigator
  
  守村敏史
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 組織細胞化学2014（日本組織細胞化学会編）2014
- Author(s)
  守村　敏史
- Total Pages
  8
- Publisher
  中西印刷
- Data Source
  KAKENHI-PROJECT-26450403
[Book] Nova Publisher, Inc (Hauppauge, NY)2013
- Author(s)
  Urushitani M, Morimura T.
- Total Pages
  24
- Publisher
  Molecular Target Therapy against Amyotrophic Lateral Sclerosis. In Amyotrophic Lateral Sclerosis.
- Data Source
  KAKENHI-PROJECT-23580417
[Book] 遺伝子医学MOOK別冊　細胞死研究の今ー疾患との関わり、創薬に向けてのアプローチ2013
- Author(s)
  守村敏史、高橋良輔、漆谷真
- Total Pages
  8
- Publisher
  メディカルドウ
- Data Source
  KAKENHI-PROJECT-23580417
[Book] ミスフォールド蛋白質による神経細胞死と治療戦略辻本賀英(編)遺伝子医学MOOK別冊細胞死研究の今—疾患との関わり、創薬に向けてのアプローチ2013
- Author(s)
  守村敏史、高橋良輔、漆谷真
- Publisher
  メディカルドウ社
- Data Source
  KAKENHI-PROJECT-23580417
[Book] Molecular target therapy against Amyotrophic Lateral Sclerosis. In K. Segawa & R. Ijichi (Eds.) Amyotrophic Lateral Sclerosis. Hauppauge, NY2012
- Author(s)
  Urushitani M, Morimura T.
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-23580417
[Journal Article] In vivo analysis of aggregation propensity of low levels of mislocalized TDP-43 on cytopathological and behavioral phenotype of ALS/FTLD2023
- Author(s)
  Wada H, Hikiami R, Kusui M, Minamiyama S, Asada-Utsugi M, Shodai A, Muramatsu SI, Morimura T, Urushitani M.
- Journal Title
  
  Neuroscience Research
  
  Volume: 印刷中 Pages: 41-51
- DOI
  10.1016/j.neures.2023.02.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-23K24211
[Journal Article] Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro2022
- Author(s)
  Asada-Utsugi Megumi、Uemura Kengo、Ayaki Takashi、T. Uemura Maiko、Minamiyama Sumio、Hikiami Ryota、Morimura Toshifumi、Shodai Akemi、Ueki Takatoshi、Takahashi Ryosuke、Kinoshita Ayae、Urushitani Makoto
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 00-00
- DOI
  10.1038/s42003-022-03312-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03573, KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-19K16277
[Journal Article] Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates2022
- Author(s)
  Hikiami R, Morimura T, Ayaki T, Tsukiyama T, Morimura N, Kusui M, Wada H, Minamiyama S, Shodai A, Asada-Utsugi M, Muramatsu SI, Ueki T, Takahashi R, Urushitani M.
- Journal Title
  
  Scxeintific Reports
  
  Volume: 12 Issue: 1 Pages: 16030-16046
- DOI
  10.1038/s41598-022-20405-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-22K06429, KAKENHI-PROJECT-22K19246, KAKENHI-ORGANIZER-20H05760, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-23K23794, KAKENHI-PROJECT-23K24211
[Journal Article] Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis2020
- Author(s)
  Buyandelger Undral、Walker Douglas G.、Yanagisawa Daijiro、Morimura Toshifumi、Tooyama Ikuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 10 Pages: 3635-3635
- DOI
  10.3390/ijms21103635
- NAID
  120006862374
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-19K07843
[Journal Article] Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-β precursor protein2020
- Author(s)
  Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T, Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: - Issue: 1 Pages: 45-60
- DOI
  10.3233/jad-191081
- NAID
  120006859791
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17K08077, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-17K17812, KAKENHI-PROJECT-20K21370, KAKENHI-PROJECT-19K16023, KAKENHI-PROJECT-20K16491, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-18H02566
[Journal Article] Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals.2018
- Author(s)
  Tamaki Y, Shodai A, Morimura T, Hikiami R, Minamiyama S, Ayaki T, Tooyama I, Furukawa Y, Takahashi R, Urushitani M.
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中 Issue: 1 Pages: 6030-6030
- DOI
  10.1038/s41598-018-24463-3
- NAID
  120006482849
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08077, KAKENHI-PROJECT-26290023, KAKENHI-PUBLICLY-17H05705, KAKENHI-PUBLICLY-18H04564, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-16K18383
[Journal Article] CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.2016
- Author(s)
  Uchida T, Tamaki Y, Ayaki T, Shodai A, Kaji S, Morimura T, Banno Y, Nishitsuji K, Sakashita N, Maki T, Yamashita H, Ito H, Takahashi R, Urushitani M.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 19118-19136
- DOI
  10.1038/srep19118
- NAID
  120005689210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26450403, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-26670190, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-26290023, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-16K08712
[Journal Article] Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria medicine, cloroquine2014
- Author(s)
  Morimura T, Numata Y, Nakamura S, Hirano E, Gotoh L, Goto YI, Urushitani M, Inoue K.
- Journal Title
  
  Exp. Biol. Med. (Maywood)
  
  Volume: 239 Pages: 489-501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580417
[Journal Article] Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine.2014
- Author(s)
  Morimura T, Numata Y, Nakamura S, Hirano E, Gotoh L, Goto YI, Urushitani M, Inoue K.
- Journal Title
  
  Exp Biol Med
  
  Volume: 239 Issue: 4 Pages: 489-501
- DOI
  10.1177/1535370213520108
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23580417, KAKENHI-PROJECT-25670485
[Journal Article] Aberrant assembly of RNA-recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein-43 (TDP-43)2013
- Author(s)
  Shodai A, Morimura T, Ido A, Uchida T, Ayaki T, Takahashi R, Kitazawa S, Suzuki S, Shirouzu M, Kigawa T, Muto Y, Yokoyama S, Takahashi R, Kitahara R, Ito H, Fujiwara N, Urushitani M
- Journal Title
  
  J Biol Chem
  
  Volume: 288(21) Issue: 21 Pages: 14886-14905
- DOI
  10.1074/jbc.m113.451849
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23370080, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23580417, KAKENHI-PROJECT-23591259, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-25840025
[Journal Article] Depletion of molecular chaperones from the endoplasmic reticulum and fragmentation of the Golgi apparatus associated with pathogenesis in Pelizaeus-Merzbacher disease2013
- Author(s)
  Numata Y, Morimura T, Nakamura S, Hirano E, Kure S, Goto YI, Inoue K.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 288 Pages: 7451-7466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580417
[Journal Article] Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43)2013
- Author(s)
  Shodai A, Morimura T, Ido A, Uchida T, Ayaki T, Takahashi R, Kitazawa S, Suzuki S, Shirouzu M, Kigawa T, Muto Y, Yokoyama S, Takahashi R, Kitahara R, Ito H, Fujiwara N, Urushitani M.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 288 Pages: 14886-14905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580417
[Journal Article] Depletion of molecular chaperones from the endoplasmic reticulum and fragmentation of the Golgi apparatus associated with pathogenesis in Pelizaeus-Merzbacher disease.2013
- Author(s)
  Numata Y, Morimura T, Nakamura S, Hirano E, Kure S, Goto YI, Inoue, K.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 288 Issue: 11 Pages: 7451-7466
- DOI
  10.1074/jbc.m112.435388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580417, KAKENHI-PROJECT-23659531, KAKENHI-PROJECT-24659486
[Journal Article] Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-432012
- Author(s)
  Shodai A
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 12 Pages: e52776-e52776
- DOI
  10.1371/journal.pone.0052776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300131, KAKENHI-PROJECT-23580417, KAKENHI-PROJECT-23591259, KAKENHI-PROJECT-24300132, KAKENHI-PLANNED-23111002
[Journal Article] Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-432012
- Author(s)
  Shodai A, Ido A, Fujiwara N, Ayaki T, Morimura T, Oono M, Uchida T, Takahashi R, Ito H, Urushitani M.
- Journal Title
  
  PLoS One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580417
[Journal Article] Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease2012
- Author(s)
  Yu LH, Morimura T, Numata Y, Yamamoto R, Inoue N, Antalfy B, Goto Y, Deguchi K, Osaka H, Inoue K.
- Journal Title
  
  Mol. Genet. Metab
  
  Volume: 106 Pages: 108-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580417
[Journal Article] Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease.2012
- Author(s)
  Yu LH, Morimura T, Numata Y, Yamamoto R, Inoue N, Antalfy B, Goto Y, Deguchi K, Osaka H, Inoue K.
- Journal Title
  
  Molecular Genetics and Metabolism
  
  Volume: 106 Pages: 108-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580417
[Journal Article] Analysis of relative roles of the individual phosphotyrosine of Disabled-1 in Reelin signaling2009
- Author(s)
  Morimura, T., Ogawa M
- Journal Title
  
  Neuroscience Research 65
- Data Source
  KAKENHI-PROJECT-20580335
[Journal Article] Relative importance of the tyrosine phosphorylation sites of Disabled-1 to the transmission of Reelin signaling2009
- Author(s)
  Morimura T, Ogawa M
- Journal Title
  
  Brain research 1304
  
  Pages: 26-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580335
[Journal Article] Relative importance of the tyrosine phosphorylation sites of Disabled-1 to the transmission of Reelin signaling2009
- Author(s)
  Toshifumi Morimura, Masaharu Ogawa
- Journal Title
  
  Brain Research 1304
  
  Pages: 26-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580335
[Journal Article] Analysis of relative roles of the individual phosphotyrosine of Disabled-1 in Reelin signaling2009
- Author(s)
  Toshifumi Morimura, Masaharu Ogawa
- Journal Title
  
  Neuroscience Research 65
- Data Source
  KAKENHI-PROJECT-20580335
[Journal Article] Visualizing spatiotemporal dynamics of multicellular cell-cycle progression.2008
- Author(s)
  Sakaue-Sawano, A., Kurokawa, H., Morimura, T., Hanyu, A., Hama, H., Osawa, H., Kashiwagi, S., Fukami, K., Miyata, T., Miyoshi, H., Imamura, T., Ogawa, M., Masai, H., and Miyawaki, A.
- Journal Title
  
  Cell 132
  
  Pages: 487-498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780222
[Journal Article] A role of Disabled-1 as a transcription factor in Reelin signaling.2007
- Author(s)
  Morimura, T., Hisatsune, C., Hattori, M., Mikoshiba, K., and Ogawa, M.
- Journal Title
  
  Neuroscience Research 58
- Data Source
  KAKENHI-PROJECT-18780222
[Journal Article] Modulation of Reelin signaling by cyclin-dependent kinase 5.2007
- Author(s)
  Ohsima, T., Suzuki, H., Morimura, T., M. Ogawa, and K Mikoshiba
- Journal Title
  
  Brain Research 1140
  
  Pages: 84-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780222
[Journal Article] Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1.2004
- Author(s)
  Suetsugu S., Tezuka T., Morimura T., Hattori M., Mikoshiba K., Yamamoto T., Takenawa T.
- Journal Title
  
  Biochemical Journal 384・1
  
  Pages: 1-8
- Data Source
  KAKENHI-PROJECT-15780192
[Journal Article] Reelinシグナルと脳の層構造形成2004
- Author(s)
  守村敏史, 小川正晴
- Journal Title
  
  The Lipid 15・5
  
  Pages: 477-480
- Data Source
  KAKENHI-PROJECT-15780192
[Journal Article] Disabled1 regulates the intracellular trafficking of Reelin receptors.
- Author(s)
  Morimura T., Hattori M., Ogawa M., Mikoshiba K.
- Journal Title
  
  The Journal of Biological Chemistry (印刷中)
- Data Source
  KAKENHI-PROJECT-15780192
[Patent] ミスフォールドタンパク質の構造変化に基づく小胞体ストレスを改善する化合物のスクリーニング方法2021
- Inventor(s)
  守村　敏史
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-058672
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K06391
[Presentation] カニクイザルの複数回採卵の試み2022
- Author(s)
  守村　敏史、清田　弥寿成、岩谷　千鶴、土屋　英明、板垣　伊織、木須　伊織、依馬　正次
- Organizer
  日本実験動物学会
- Data Source
  KAKENHI-PROJECT-20K06391
[Presentation] タウ分子病理とDNA損傷修復機構の関連について2022
- Author(s)
  浅田めぐみ，植村健吾，綾木孝，上村麻衣子，南山素三雄，引網亮太，守村敏史，小代明美，植木孝俊，高橋良輔，木下彩栄，漆谷真
- Organizer
  第41回　日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24211
[Presentation] バイオマテリアルとしてのカニクイザル不死化 Bリンパ球バンクの構築2021
- Author(s)
  守村敏史、伊藤靖、等誠司、遠山育夫、依馬正次
- Organizer
  日本獣医学会
- Data Source
  KAKENHI-PROJECT-20K06391
[Presentation] アルツハイマー病関連変異型amyloid precursor protein発現トランスジェニックカニクイザルの作出2019
- Author(s)
  守村敏史、清田弥寿成、渡邊直希、岩谷千鶴、土屋英明、中村紳一郎、鈴木利治, 依馬正次, 西村正樹, 遠山育夫
- Organizer
  第46回日本脳科学会
- Data Source
  KAKENHI-PROJECT-17K08077
[Presentation] Generating new ALS model mice replicating TDP-43 proteinopathy.2018
- Author(s)
  引網亮太、小代明美、南山素三雄、玉木良高、守村敏史、高橋　良輔、漆谷真
- Organizer
  第59回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08077
[Presentation] GTPシクロヒドロラーゼ1とその調節タンパク質GFRPのin vivo相互作用2018
- Author(s)
  Jean-Pierre Bellier, Toshifumi Morimura, Yu Xie, Ikuo Tooyama
- Organizer
  日本神経化学会
- Data Source
  KAKENHI-PROJECT-18K08853
[Presentation] In vivo interaction between GTP cyclohydrolase 1 and its regulatory protein GFRP2018
- Author(s)
  Jean-Pierre Bellier, Toshifumi Morimura, Yu Xie, Ikuo Tooyama
- Organizer
  第61回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-17K08077
[Presentation] 骨髄単核球の細胞保護型ミクログリア細胞への分化誘導法の検討～神経変性疾患の細胞治療への応用を目指して2017
- Author(s)
  小橋修平　寺島智也　中江由希　樫美和子　守村敏史　小島秀人漆谷真
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-26450403
[Presentation] Degradative intrabody for selective elimination of pathogenic TDP-43 aggregates in vitro and in murine embryos' cerebrum.2017
- Author(s)
  Tamaki Y, Shodai A, Hikiami R, Minamiyama S, Morimura T, Ayaki T, Takahashi R, Urushitani M.
- Organizer
  World Congress of Neurology
- Data Source
  KAKENHI-PROJECT-17K08077
[Presentation] Development of an effective technology for inductive differentiation from bone marrow-derived mononuclear cells to neuroprotective microglia.2017
- Author(s)
  Kobashi S, Terashima T, Nakae Y, Katagi M , Morimura T, Kojima H, Urushitani M.
- Organizer
  World Congress of Neurology
- Data Source
  KAKENHI-PROJECT-17K08077
[Presentation] Degradative intrabody for selective elimination of pathogenic TDP-43 aggregates in vitro and in murine embryos’ cerebrum2017
- Author(s)
  Tamaki Y, Shodai A, Hikiami R, Minamiyama S, Morimura T, Ayaki T, Takahashi R, Urushitani M.
- Organizer
  World Congress of Neurology. 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] Development of an effective technology for inductive differentiation from bone marrow-derived mononuclear cells to neuroprotective microglia.2017
- Author(s)
  Kobashi S, Terashima T, Nakae Y, Katagi M, Morimura T, Kojima H, Urushitani M
- Organizer
  World Congress of Neurology. 2017,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] ER-Golgi transport may serve as a novel drug target for Pelizaeus-Merzbacher disease caused by PLP1 amino acid substitutions.2016
- Author(s)
  K Inoue, H Li, P.R.Mangalika, A Nishizawa, Y Numata, S Nakamura, T Morimura, H Saya, Y Goto.
- Organizer
  13th International Congress of Human Genetics.
- Place of Presentation
  Kyoto
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450403
[Presentation] VHL とCUL2; TDP-43 の凝集を促進するVHL と分解を促進するCUL2. TDP-43 proteinopathy におけるVHL の2 面性2015
- Author(s)
  内田司, 玉木良高, 小代明美, 綾木孝, 守村敏史, 辰巳新水, 伊東秀文, 坂下直実, 高橋良輔, 漆谷真
- Organizer
  第56回日本神経学会　学術集会
- Place of Presentation
  新潟市
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] VHLとCUL2;TDP-43の凝集えを促進するVHLと分解を促進するCUL22015
- Author(s)
  内田　司、小代　明美、玉木　良高、辰己　新水、守村　敏史、綾木　孝、伊藤　秀文、坂下　直美、高橋　良輔、漆谷　真
- Organizer
  第56回日本神経学会
- Place of Presentation
  新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26450403
[Presentation] ALSのTDP-43のinclusion形成におけるVon Hippel-Lindau proteinの役割2014
- Author(s)
  内田司，小代明美，守村敏史，辰巳新水，高橋良輔，漆谷真
- Organizer
  第３7回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] TDP-43のCullin-2型E3リガーゼの同定及び機能解析2014
- Author(s)
  内田司, 小代明美, 大野美樹, 辰巳新水, 守村敏史, 高橋良輔, 漆谷真
- Organizer
  第55回日本神経学会学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] Preclinical studies for the treatment of Pelizaeus-Merzbacher disease with clinically applicable compounds, curumin and chloroquine2013
- Author(s)
  Inoue K, Morimura T,Numata Y,Yu L-H, Gotoh L, Yamamoto R, Inoue N, Antalfy B, Deguchi K, Osaka H, Goto Y.
- Organizer
  23rd Meeting of the European Neurological Society
- Place of Presentation
  Barcelona, Spain (一般)
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] More than ER stress : molecular mechanism for misfolded PLP1 that impacts subcellular dynamics and clinical severity of Pelizaeus-Merzbacher disease2013
- Author(s)
  Numata Y, Morimura T, NakamuraS, Hirano E, Kure S, Goto Y, Inoue K.
- Organizer
  62rd Annual meeting of the American Society of Human Genetics
- Place of Presentation
  Boston, USA(一般)
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] More than ER stress: molecular mechanism for misfolded PLP1 that impacts subcellular dynamics and clinical severity of Pelizaeus-Merzbacher disease. 2013.10.22-26.2013
- Author(s)
  Numata Y, Morimura T, Nakamura S, Hirano E, Kure S, Goto Y, Inoue K.
- Organizer
  62rd Annual meeting of the American Society of Human Genetics
- Place of Presentation
  ボストン（アメリカ）
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] Preclinical studies for the treatment of Pelizaeus-Merzbacher disease with clinically applicable compounds, curumin and chloroquine.2013
- Author(s)
  InoueK, Morimura T,Numata Y,Yu L-H, Gotoh L, Yamamoto R, Inoue N, Antalfy B, Deguchi K, Osaka H, Goto Y.
- Organizer
  23rd Meeting of the European Neurological Society
- Place of Presentation
  バルセロナ（スペイン）
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] Treating Pelizaeus-Merzbacher disease with clinically applicable compounds, curumin and chloroquine : preclinical studies2012
- Author(s)
  Inoue K, Morimura T, Numata Y, Yu, H, Gotoh L, Yamamoto R, Inoue N, Antalfy B, Deguchi K, Osaka H, Goto Y.
- Organizer
  62nd Annual meeting of the American Society of Human Genetics
- Place of Presentation
  San Francisco, USA(一般)
- Year and Date
  2012-11-08
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] Pelizaeus-Merzbacher病の治療法開発への試み2012
- Author(s)
  井上　健、守村　敏史、沼田　有里佳、Li-Hua Yu、後藤　玲央、山本　良子、井上　直子、出口　貴美子、小坂　仁、後藤　雄一
- Organizer
  第57回日本人類遺伝学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] 培養細胞モデルを用いたALSにおけるTDP-43の分子的機構の解析2012
- Author(s)
  内田司,井戸明美,小代明美,大野美樹、守村敏史,高橋良輔,漆谷真
- Organizer
  第35回神経科学大会
- Place of Presentation
  名古屋(一般)
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] 培養細胞モデルを用いたALSにおけるTDP-43の分子的機構の解析2012
- Author(s)
  内田　司,　井戸　明美,　小代　明美,　大野　美樹、守村　敏史,　高橋　良輔,　漆谷　真
- Organizer
  第35回神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] テトラサイクリン誘導性にTDP-43を発現するヒト神経由来細胞の樹立とその応用2012
- Author(s)
  内田　司,　井戸　明美,　小代　明美,　守村　敏史,　高橋　良輔,　漆谷　真
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] 小胞体ストレス型Pelizaeus-Merzbacher病に対する抗マラリア薬であるクロロキンの応用2012
- Author(s)
  守村敏史、沼田由里佳、有馬恵里子、後藤玲央、後藤雄一、井上健
- Organizer
  第35回神経科学大会
- Place of Presentation
  名古屋(一般)
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] テトラサイクリン誘導性にTDP-43を発現するヒト神経由来細胞の樹立とその応用2012
- Author(s)
  内田司,井戸明美,小代明美,守村敏史,高橋良輔,漆谷真
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京(一般)
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] 小胞体ストレス関連疾患（Pelizaeus-Merzbacher病）における、小胞体からのシャペロンの排除2012
- Author(s)
  沼田有里佳，守村敏史，有馬恵里子，後藤雄一，井上　健
- Organizer
  第35回神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] Pelizaeus-Merzbacher disease with clinically applicable compounds, curumin and chloroquine: preclinical studies.2012
- Author(s)
  Inoue K, Morimura T, NumataY, Yu H, Gotoh L, Yamamoto　R, Inoue N, Antalfy B, Deguchi K, Osaka H, Goto Y.
- Organizer
  62nd Annual meeting of the American Society of Human Genetics
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] Pelizaeus-Merzbacher病の治療法開発への試み2012
- Author(s)
  井上健、守村敏史、沼田有里佳、Li-Hua Yu、後藤玲央、山本良子、井上直子、出口貴美子、小坂仁、後藤雄一
- Organizer
  第57回日本人類遺伝学会
- Place of Presentation
  東京(一般)
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] 小胞体ストレス関連疾患(Pelizaeus-Merzbacher病)における、小胞体からのシャペロンの排除2012
- Author(s)
  沼田有里佳,守村敏史,有馬恵里子,後藤雄一,井上健
- Organizer
  第35回神経科学大会
- Place of Presentation
  名古屋(一般)
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] 小胞体ストレス型Pelizaeus-Merzbacher病に対する抗マラリア薬であるクロロキンの応用2012
- Author(s)
  守村敏史、沼田由里佳、有馬恵里子、後藤　玲央、後藤雄一、井上健
- Organizer
  第35回神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] フレームシフト変異によるPLP1mRNAの不安定化:軽症型Pelizaeus-Merzbacher病の分子病態2011
- Author(s)
  沼田有里佳、守村敏史、畠山英之、横田睦美、後藤雄一、涌澤圭介、植松貢、大沼晃、井上健
- Organizer
  第56回人類遺伝学会
- Place of Presentation
  千葉(一般)
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] 小胞体ストレスを標的としたPelizaeus-Merzbacher病に対する治療薬の確立2011
- Author(s)
  守村敏史、沼田由里佳、有馬恵里子、後藤雄一、井上健
- Organizer
  第33回日本神経科学大会
- Place of Presentation
  横浜(一般)
- Year and Date
  2011-09-11
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] 小胞体ストレスを標的とした Pelizaeus-Merzbacher 病に対する治療薬の確立2011
- Author(s)
  守村敏史、沼田由里佳、有馬恵里子、後藤雄一、井上健
- Organizer
  第３４回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] フレームシフト変異によるPLP1mRNAの不安定化：軽症型Pelizaeus-Merzbacher病の分子病態2011
- Author(s)
  沼田　有里佳、守村　敏史、畠山　英之、横田　睦美、後藤　雄一、涌澤圭介、植松　貢、大沼　晃、井上　健
- Organizer
  第５６回人類遺伝学会
- Place of Presentation
  幕張メッセ（千葉市）
- Data Source
  KAKENHI-PROJECT-23580417
[Presentation] Analysis of relative roles of the individual phosphotyrosine of Disabled-1 in Reelin signaling2009
- Author(s)
  Morimura T., Ogawa M.
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋国際会議場、名古屋
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-20580335
[Presentation] Analysis of relative roles of the individual phosphotyrosine of Disabled-1 in Reelin signaling2009
- Author(s)
  Toshifumi Morimura, Masaharu Ogawa
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋、名古屋国際会議場
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-20580335
[Presentation] A role of Disabled-1 as a transcription factor in Reelin signaling.2007
- Author(s)
  Morimura, T., Hisatsune, C., Hattori, M., Mikoshiba, K., and Ogawa, M.
- Organizer
  Neuro2007(第30回日本神経学大会、第50回日本神経化学会大会、第17回神経回路学会大会)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-18780222
[Presentation] 子宮内エレクトロポレーションによる神経系での遺伝子産物の解析
- Author(s)
  守村　敏史
- Organizer
  第39回組織細胞化学講習会
- Place of Presentation
  滋賀県大津市（ピアザ淡水）
- Year and Date
  2014-08-06 – 2014-08-08
- Invited
- Data Source
  KAKENHI-PROJECT-26450403
[Presentation] PLP1 missense mutations impair subcellular organelle dynamics that impact clinical severity of Pelizaeus-Merzbacher disease.
- Author(s)
  Inoue K, Numata Y, Morimura T, Nakamura S, Goto Y.
- Organizer
  Biennial Meeting of the International Society for Developmental Neuroscience.
- Place of Presentation
  Hilton Montreal Bonaventure, Montreal, Canada
- Year and Date
  2014-07-19 – 2014-07-24
- Data Source
  KAKENHI-PROJECT-26450403
[Presentation] PLP1点変異の新規分子病態を標的としたドラッグ・リポジショニングによるPelizaeus-Merzbacher病の治療法開発
- Author(s)
  井上　健、マンガリイ・プリアンティ、沼田　有里佳、中村　祥子、守村　敏史、佐谷　秀行、後藤　雄一
- Organizer
  第59回日本人類遺伝学会
- Place of Presentation
  東京都（タワーホール船堀）
- Year and Date
  2014-11-19 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-26450403

1. Makoto Urushitani (60332326)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
2. 依馬正次 (60359578)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. OGAWA Masaharu (50111951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. INOUE Ken (30392418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
5. Bellier Jean-Pierre (80346022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 野崎和彦 (90252452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松本翔馬 (00881517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 辻敬一 (80838045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 河野浩人 (90894056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 青木友浩 (40633144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山海直 (80300937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 和泉唯信 (10335812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 森野豊之 (10397953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 柳沢大治郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 高橋良輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 西村正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morimura Toshifumi 守村 敏史

MORIMURA Toshifumi 守村 敏史

守村 敏史 モリムラ トシフミ

Research Projects

Research Products

Co-Researchers

Pathological and diagnostic significance of the N-terminal fragment of TDP-43 in ALSPrincipal Investigator

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PKD遺伝子異常に伴う脳動脈瘤発生の病態解明

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新規ミトコンドリア蛋白質の構造異常によるALS病態の解析と評価モデル系の開発

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Drug discovery against ER stress by using a novel luminescence probe sensing ER environmentsPrincipal Investigator

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Evaluation of an immunotherapy for chronic pain by expressing a single domain intrabody against the pain marker GCH1 in the rat dorsal root ganglion neurons

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Pathological and therapeutic research of sporadic ALSPrincipal Investigator

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Development of a novel molecular targeting therapy and probe, using antibodies against pathogenic epitopes in TDP-43

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Analysis of ALS related gene products in the mouse central nerve systemPrincipal Investigator

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Clinical application of autophagy-inducing factors from food supplementsPrincipal Investigator

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Functional analysis of Dab1as a transcription factor for transmission of Reelin signalingPrincipal Investigator

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細胞内アダプター蛋白質Dab1によるニューロンの位置決定機構の解析Principal Investigator

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大脳皮質の構築に必須なアダプター蛋白質Dab1及びその結合蛋白質の機能解析Principal Investigator

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[Book] 組織細胞化学2014（日本組織細胞化学会編）2014

Author(s)

Morimura Toshifumi 守村敏史

MORIMURA Toshifumi 守村敏史

守村敏史モリムラトシフミ

[Book] 遺伝子医学MOOK別冊　細胞死研究の今ー疾患との関わり、創薬に向けてのアプローチ2013