Maruyama Wakako 丸山和佳子

… Alternative Names

MARUYAMA Wakako 丸山和佳子

丸山和佳子マルヤマワカコ

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Researcher Number	20333396
Other IDs
External Links
Affiliation (Current)	2025: 愛知学院大学, 健康科学部, 教授 2025: 国立研究開発法人国立長寿医療研究センター, その他部局等, その他
Affiliation (based on the past Project Information) *help	2023: 愛知学院大学, 健康科学部, 教授 2018 – 2022: 愛知学院大学, 心身科学部, 教授 2012 – 2014: 独立行政法人国立長寿医療研究センター, 加齢健康脳科学研究部, 部長 2013: 独立行政法人国立長寿医療研究センター, その他部局等, 部長 2010: 独立行政法人国立長寿医療研究センター, 加齢健康脳科学研究部, 部長 … More 2009: National Institute for Longevity Sciences,NCGG, 老年病研究部, 部長 2004 – 2005: 国立長寿医療センター, 老年病研究部, 部長(研究職) 2004: 国立長寿医療センター, (研究所)・老年病研究部, 部長 2004: National Center for Geriatrics and Gerontology, Department of Geriatric Medicine, Head, 老年病研究部, 部長 2003: 国立長寿医療センター, 老化機構研究部・代謝研究室, 室長 2002: NATIONAL INSTITUTE FOR LONGEVITY SCIENCES DEPARTMENT OF BASIC GERONTOLOGY SECTION CHIEF, 長寿医療研究センター・老化機構研究部, 室長 2001: 国立療養所中部病院(長寿医療研究センター), 老化機構研究部, 室長 Less
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Neurology / Neurology / Applied health science / Biological Sciences Except Principal Investigator Food science / Laboratory medicine
Keywords	Principal Investigator パーキンソン病 / 酸化ストレス / 脂質過酸化 / 口腔炎症 / complex I / 神経変性 / ミトコンドリア / アルファシヌクレイン / 構造異常アルファシヌクレイン / 口腔内炎症 … More / ミエロペルオキシダーゼ / アルファーシヌクレイン / シヌクレイン / 神経老化 / オートファジー / alpha-synuclein / Japanese monkey / Cerebrospinal fluid / Transcription factor / Propargylamine / Alzheimer's disease / Parkinson's disease / Neurotrophic factor / Neuroprotective drug / モノアミンオキシダーゼ / プロパルジルアミン / NFκB / BCL-2 / ニホンザル / 脳脊髄液 / 転写制御 / propargylamine / アルツハイマー病 / 神経栄養因子 / 神経保護薬 / OXIDATIVE STRESS / PROTEOME / PROTEIN AGGREGATION / DIAGNOSTIC MARKER / OXIDIZED PROTEIN / PROTEASOME / MITOCHONDRIA / PARKINSON DISEASE / peroxynitrite / 酸化タンパク / 老化 / タンパク凝集 / プロテオーム解析 / たんぱく凝集 / 診断マーカー / 酸化修飾たんぱく / プロテアソーム / 加齢・老化 / N-methyl(R)salsolinol / ミトコンドリア膜透過性(PT) / アポトーシス … More Except Principal Investigator 酸化ストレスバイオマーカー / 脳内老化 / 抗酸化食品因子 / Antibody-chip / Tetrahydrocurcumin / Inflammation reaction / Antioxidative food factors / A-beta-amyloids / Parkinson syndrome / Alzheimer's disease / Anti-brain aging / ゴマリグナン / モノクローナル抗体 / DHA / パーキンソン症 / 高酸化食品因子 / 抗体チップ / テトラヒドロクルクミン / 炎症反応 / Aβタンパク質 / パーキンソン病 / アルツハイマー病 / 脳内老化抑制 / 突発性正常水頭症 / 糖鎖解析 / 髄液 / マーカー / Ｎ結合型糖鎖 / 脳脊髄液 / アミノリン脂質修飾 / 抗炎症反応 / アスタキサンチン / アルツハイマー症 / 脳内神経細胞 / リポソーム / ヘキサノイル型付加体 / プロパノイル型付加体 / アルキルアミド型付加体 Less

Oral inflammation induces Parkinson disease via production of oxidized synucleinPrincipal Investigator
- Principal Investigator
  
  Maruyama Wakako
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Aichi Gakuin University
Membrane lipid peroxidation is involved in the pathogenesis of Parkinson diseasePrincipal Investigator
- Principal Investigator
  
  Maruyama Wakako
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Aichi Gakuin University
Establishment and application of evaluation system of brain aging using alkyl-amide adducts as probe
- Principal Investigator
  
  OSAWA TOSHIHIKO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Food science
- Research Institution
  Aichi Gakuin University
Development of a technology to analyze total N-glycans contained in cerebrospinal fluid
- Principal Investigator
  
  IKENAKA Kazuhiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  National Institute for Physiological Sciences
老化シグナルを制御し、神経変性を予防する食品成分の開発Principal Investigator
- Principal Investigator
  
  丸山和佳子
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied health science
- Research Institution
  National Center for Geriatrics and Gerontology
Establishment of oxidative stress biomarkers in regulation of brain-aging and protective role of antioxidative food factors
- Principal Investigator
  
  OSAWA Toshihiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Food science
- Research Institution
  Nagoya University
Development of a drug, which can pass the blood-brain barrier and induces neuroprotective proteins in the brain.Principal Investigator
- Principal Investigator
  
  MARUYAMA Wakako
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY
孤発性パーキンソン病の神経細胞変性の機序;ミトコンドリアにおける細胞死制御機構Principal Investigator
- Principal Investigator
  
  丸山和佳子
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Longevity Sciences,NCGG
THE MECHANISM OF NEURONAL AGING : THE INACTIVATION AND CONFORMATIONAL CHANGE OF PROTEINS BY OXIDATIVE MODIFICATIONPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Wakako
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  NATIONAL INSTITUTE FOR LONGEVITY SCIENCES

[Book] Lipid Hydroperoxide-Derived Modification of Biomolecules（Subcellular Biochemistry 77)2014
- Author(s)
  Maruyama W, Shaomoto-Nagai M, Kato Y, Hisaka S, Osawa T, Naoi M.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-24248024
[Book] A Handbook of Neurotoxicity2013
- Author(s)
  Naoi M, Maruyama W.
- Publisher
  Springer Science Publishing
- Data Source
  KAKENHI-PROJECT-24248024
[Book] Current Topics in Medical Chemistry2013
- Author(s)
  Naoi M, Maruyama W, Inaba-Hasegawa K.
- Publisher
  Bentham Science Publishers
- Data Source
  KAKENHI-PROJECT-24248024
[Book] アスタキサンチンの機能と応用2012
- Author(s)
  丸山和佳子、永井雅代、能勢弓、大澤俊彦、直井信
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-24248024
[Book] 機能性食品・素材と運動療法ー生活習慣病予防と運動機能維持、向上をめざしてー2012
- Author(s)
  丸山和佳子、永井雅代、能勢弓、大澤俊彦、直井信
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-24248024
[Book] Oxidative Stress, Inflammation and Health2005
- Author(s)
  Maruyama W, Akao Y, Nitta A, Naoi M.
- Total Pages
  240
- Data Source
  KAKENHI-PROJECT-15590925
[Book] Oxidative Stress, Inflammation and Health2005
- Author(s)
  Naoi M, Maruyama W, Shamoto-Nagai M, Kato Y, Tanaka M.
- Total Pages
  240
- Data Source
  KAKENHI-PROJECT-15590925
[Book] 神経保護薬2004
- Author(s)
  丸山和佳子, 直井信
- Total Pages
  165
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Book] Parkinson病の発症機序-Up date2004
- Author(s)
  丸山和佳子, 直井信
- Total Pages
  122
- Data Source
  KAKENHI-PROJECT-15590925
[Book] 神経保護薬2004
- Author(s)
  丸山和佳子, 直井信
- Total Pages
  800
- Data Source
  KAKENHI-PROJECT-15590925
[Book] Monoamine Oxidase inhibitors and their role in neurotransmission2004
- Author(s)
  Naoi M, Maruyama W.
- Total Pages
  403
- Data Source
  KAKENHI-PROJECT-15590925
[Book] Parkinson病の発症機序-Up date2004
- Author(s)
  丸山和佳子, 直井信
- Total Pages
  110
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Book] 神経毒によるパーキンソン病モデル:細胞死機序の解明と神経保護薬の開発2004
- Author(s)
  直井信, 丸山和佳子
- Total Pages
  575
- Data Source
  KAKENHI-PROJECT-15590925
[Book] Mercel Dekker, New York, Oxidative Stress, Inflammation and Health(Surh Y-J. (ed))2004
- Author(s)
  Maruyama W, Akao Y, Nitta A, Naoi M.
- Total Pages
  240
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Book] Mercel Dekker, New York, Oxidative Stress, Inflammation and Health(Surh Y-J. (ed))2004
- Author(s)
  Naoi M, Maruyama W, Shamoto-Nagai M, Kato Y, Tanaka M.
- Total Pages
  240
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Book] Medicina Publishing House, Budapest, Milestones in monoamine resarch.(Lorok Tl (ed))2003
- Author(s)
  Naoi M, Maruyama W.
- Total Pages
  420
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Book] 孤発性パーキンソン病の病因2003
- Author(s)
  丸山和佳子, 直井信
- Total Pages
  110
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] 高齢者のフレイルと認知症に関する最近の話題2024
- Author(s)
  丸山和佳子
- Journal Title
  
  全国歯科衛生士教育協議会雑誌
  
  Volume: 28 Pages: 3-6
- Data Source
  KAKENHI-PROJECT-21K07402
[Journal Article] Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson’s disease2024
- Author(s)
  Naoi Makoto、Maruyama Wakako、Shamoto-Nagai Masayo、Riederer Peter
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: in press Issue: 6 Pages: 639-661
- DOI
  10.1007/s00702-023-02730-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07402
[Journal Article] Phytochemical in synucleinopathies: Targeting mitochondrial dysfunction and a-synuclein toxicity.2022
- Author(s)
  Naoi M, Maruyama M, Shamoto-Nagai M
- Journal Title
  
  Studies in Natural Product Chemistry
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-21K07402
[Journal Article] N-Methyl-(R)salsolinol and enzymes involved in enantioselective biosynthesis, bioactivation, and toxicity in Parkinson’s disease.2022
- Author(s)
  Naoi M, Maruyama W
- Journal Title
  
  Handbook of Neurotoxicology
  
  Volume: - Pages: 1573-1592
- Data Source
  KAKENHI-PROJECT-21K07402
[Journal Article] Ginseng and ginsenosides in depression.2022
- Author(s)
  Naoi M, Maruyama M, Shamoto-Nagai M
- Journal Title
  
  NeuroPsyvhopharmacology
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-21K07402
[Journal Article] Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies2022
- Author(s)
  Naoi Makoto、Maruyama Wakako、Shamoto-Nagai Masayo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 19 Pages: 11059-11059
- DOI
  10.3390/ijms231911059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07402
[Journal Article] Parkinsonian toxins: From MPTP to endogenous neurotoxin2022
- Author(s)
  Naoi M, Maruyama M, Shamoto-Nagai M
- Journal Title
  
  NeuroPsyvhopharmacology
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-21K07402
[Journal Article] Nutrition in Brain Ageing; Its relevance to Age-associated Neurodegeneration.2021
- Author(s)
  Maruyama W, Shamoto-Nagai M, Naoi M.
- Journal Title
  
  NeuroPsychopharmacology
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07402
[Journal Article] Disease-modifying treatment of Parkinson’s disease by phytochemicals: targeting multiple pathogenic factors2021
- Author(s)
  Naoi Makoto、Maruyama Wakako、Shamoto-Nagai Masayo
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: - Issue: 5-6 Pages: 737-753
- DOI
  10.1007/s00702-021-02427-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07402
[Journal Article] TCM substances in Neuropsychopharmaco-therapy: Basic Aspects with a focus on depression.2021
- Author(s)
  Naoi M, Maruyama W, Riederer P.
- Journal Title
  
  NeuroPsychopharmacology
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07402
[Journal Article] Rasagiline and selegiline modulate mitochondrial homeostasis, intervene apoptosis system and mitigate α-synuclein cytotoxicity in disease-modifying therapy for Parkinson's disease.2020
- Author(s)
  Naoi M, Maruyama W, Shamoto-Nagai M.
- Journal Title
  
  J Neural Transm
  
  Volume: 127 Pages: 131-147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07430
[Journal Article] Neuroprotection of multifunctional phytochemicals as novel therapeutic strategy for neurodegenerative disorders: antiapoptotic and antiamyloidogenic activities by modulation of cellular signal pathways.2019
- Author(s)
  Naoi Makoto、Maruyama Wakako、Shamoto-Nagai Masayo
- Journal Title
  
  Future Neurol.
  
  Volume: 14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07430
[Journal Article] Mitochondria in Neuroprotection by Phytochemicals: Bioactive Polyphenols Modulate Mitochondrial Apoptosis System, Function and Structure2019
- Author(s)
  Naoi Makoto、Wu Yuqiu、Shamoto-Nagai Masayo、Maruyama Wakako
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 10 Pages: 2451-2451
- DOI
  10.3390/ijms20102451
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07430
[Journal Article] 要介護高齢者と健常高齢者における口腔機能と全身状態の関連2019
- Author(s)
  西口寛一朗，小島規永，永井雅代，熊野弘一，丸山和佳子，武部　純
- Journal Title
  
  愛知学院大学歯学会誌
  
  Volume: 57 Pages: 259-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07430
[Journal Article] Type A and B monoamine oxidases distinctly modulate signal transduction pathway and gene expression to regulate brain function and survival of neurons2018
- Author(s)
  Naoi Makoto、Maruyama Wakako、Shamoto-Nagai Masayo
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 125 Issue: 11 Pages: 1635-1650
- DOI
  10.1007/s00702-017-1832-6
- Data Source
  KAKENHI-PROJECT-18K07430
[Journal Article] Modification of α-synuclein by lipid peroxidation products derived from polyunsaturated fatty acids promotes toxic oligomerization: its relevance to Parkinson disease2018
- Author(s)
  Shamoto-Nagai Masayo、Hisaka Shinsuke、Naoi Makoto、Maruyama Wakako
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 62 Issue: 3 Pages: 207-212
- DOI
  10.3164/jcbn.18-25
- NAID
  130006730724
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07430
[Journal Article] Introduction to the special issue on monoamine oxidase A and B: eternally enigmatic isoenzymes2018
- Author(s)
  Shih Jean Chen、Riederer Peter、Maruyama Wakako、Naoi Makoto
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 125 Issue: 11 Pages: 1517-1518
- DOI
  10.1007/s00702-018-1920-2
- Data Source
  KAKENHI-PROJECT-18K07430
[Journal Article] Modulation of monoamine oxidase (MAO) expression in neuropsychiatric disorders: genetic and environmental factors involved in type A MAO expression.2015
- Author(s)
  Naoi M, Riederer P, Maruyama W.
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 印刷中 Issue: 2 Pages: 91-106
- DOI
  10.1007/s00702-014-1362-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24248024
[Journal Article] SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation.2015
- Author(s)
  Hayakawa T, Iwai M, Aoki S, Takimoto K, Maruyama M, Maruyama W, Motoyama N.
- Journal Title
  
  PLoS One.
  
  Volume: 10(1) Issue: 1 Pages: e0116480-e0116480
- DOI
  10.1371/journal.pone.0116480
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24248024, KAKENHI-PROJECT-24590369
[Journal Article] Rasagiline and selegiline suppress calcium effux from mitochondria by PK11195-induced opening of mitochondrial permeability transition pore: a novel anti-apopticfunction for neuroprotection2015
- Author(s)
  Wu, Y., Kazumura, K., Maruyama, W., Osawa, T., Naoi, M.
- Journal Title
  
  J of Neural Transmission
  
  Volume: 印刷中 Issue: 10 Pages: 1399-1407
- DOI
  10.1007/s00702-015-1398-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24248024
[Journal Article] クルクミン誘導体、とくにテトラヒドロクルクミンによる寿命延長効果「食品と疾病―クルクミン」2015
- Author(s)
  丸山和佳子、永井雅代、山岡朗子
- Journal Title
  
  Functional Food
  
  Volume: 9(1)
- Data Source
  KAKENHI-PROJECT-24248024
[Journal Article] Rasagiline and selegiline, inhibitors of type B monoamine oxidase, induce type A monoamine oxidase in human SH-SY5Y cells.2013
- Author(s)
  Inaba-Hasegawa K, Akao Y, Maruyama W, Naoi M.
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 120(3) Issue: 3 Pages: 435-444
- DOI
  10.1007/s00702-012-0899-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24248024
[Journal Article] Rasagiline prevents apoptosis induced by PK11195, a ligand of the outer membrane translocator protein (18 kDa), in dopaminergic SH-SY5Y cells through preventing cytochrome c release from mitochondria.2013
- Author(s)
  Naoi M, Maruyama W, Yi H.
- Journal Title
  
  J Neural Transm.
  
  Volume: 120(11) Issue: 11 Pages: 1539-1551
- DOI
  10.1007/s00702-013-1033-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24248024
[Journal Article] Revelation in the neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms.2013
- Author(s)
  Naoi M, Maruyama W, Inaba-Hasegawa K.
- Journal Title
  
  Expert Rev Neurother.
  
  Volume: 13(6) Issue: 6 Pages: 671-684
- DOI
  10.1586/ern.13.60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24248024
[Journal Article] Induction of glial cell line-derived and brain-derived neurotrophic factors by rasagiline and (-)deprenyl: A way to a disease-modifying therapy?2013
- Author(s)
  Maruyama W, Naoi M
- Journal Title
  
  Journal Neural Transmission
  
  Volume: 120(1) Pages: 83-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24248024
[Journal Article] Type A monoamine oxidase is associated with induction of neuroprotective Bcl-2 by rasagiline, an inhibitor of type B monoamine oxidase.2012
- Author(s)
  Inaba-Hasegawa K, Akao Y, Maruyama W, Naoi M.
- Journal Title
  
  Journal Neural Transmission
  
  Volume: 119 Issue: 4 Pages: 405-414
- DOI
  10.1007/s00702-011-0730-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24248024
[Journal Article] Type A and B monoamine oxidase in age-related neurodegenerative disorders: their distinct roles in neuronal death and survival2012
- Author(s)
  Naoi M, Maruyama W, Inaba-Hasegawa K.
- Journal Title
  
  Curr Top Med Chem.
  
  Volume: 12(20) Issue: 20 Pages: 2177-2188
- DOI
  10.2174/1568026611212200006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24248024
[Journal Article] Monoamine oxidase inhibitors as neuroprotective agents in age-dependent neurodegenerative disorders.2010
- Author(s)
  Naoi M, Maruyama W.
- Journal Title
  
  Curr Pharm Des.
  
  Volume: 16 Pages: 2799-817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21650184
[Journal Article] Systemic disorders of calcium dynamics in rats with adenine-induced renal failure : implication for chronic kidney disease-related complications.2010
- Author(s)
  Ikeda R, Imai Y, Maruyama W, Mizoguchi K.
- Journal Title
  
  Nephrology
  
  Volume: 15 Pages: 54-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21650184
[Journal Article] functional mechanism of neuroprotection by in hibitors of type Bmonoamine oxidase in Parkinson's disease.2009
- Author(s)
  Naoi M, Maruyama W.
- Journal Title
  
  Expert Rew Neurother. 9(8)
  
  Pages: 1233-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21650184
[Journal Article] Mitochondria in neurodegenerative disorders : regulation of the redox state and death signaling leading to neuronal death and survival2009
- Author(s)
  Naoi M, Maruyama W, Yi H, Inaba K, Akao Y, Shamoto-Nagai M.
- Journal Title
  
  J Neural Transm. 116(11)
  
  Pages: 1371-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21650184
[Journal Article] Rasagiline : Neurodegeneration, neuroprotection, and mitochondrial Permeability transition.2005
- Author(s)
  Youdim MBH, Bar Am O, Yogev-Falach M, Weinreb O, Maruyama W, Naoi M.Am
- Journal Title
  
  J.Neurosci.Res 79
  
  Pages: 172-179
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Dopamine-derived salsolinol derivatives as endogenous monoamioxidase inhibitors : Occurrence, meta- bolism and function2004
- Author(s)
  Naoi M, Maruyama W, Nagy GM
- Journal Title
  
  NeuroToxicol. 25
  
  Pages: 193-204
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] N-Propargyl-1(R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Ycells through activation of NF-kappaB transcription factor.2004
- Author(s)
  Maruyama W, Nitta A, Shamoto-Nagai M, Hirata Y, Akao Y, Youdim M, Furukawa S, Nabeshima T, Naoi M.
- Journal Title
  
  Neurochem.Int. 44
  
  Pages: 393-400
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Dopamine-derived salsolinol derivatives as endogenous monoaraine oxidase inhibitors : Occurrence, metabolism and function in human brains.2004
- Author(s)
  M.Naoi, W.Maruyama, G.M.Nagy
- Journal Title
  
  Neuro Toxicology 25
  
  Pages: 193-204
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Neuroprotective function of R-(-)-(benzyofuran-2-yl) -2-propylamino-pentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells.2004
- Author(s)
  Maruyama W, Yi H, Takahashi T, Shimazu S, Ohde H, Yoneda K, Iwasa K, Naoi M.
- Journal Title
  
  Life Sci. 21
  
  Pages: 107-117
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neurobalstoma SH-SY5Y cells.2004
- Author(s)
  Akao Y, Seki N, Nakagawa Y, Yi H, Matsumoto K, Ito Y, Ito K, Funaoka M, Maruyama W, Naoi M, Nozawa Y.
- Journal Title
  
  Bioorg.Med.Chem. 12
  
  Pages: 4794-4801
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Neuroprotective function of R-(-)-(benzyofuran-2-yl)-2-propylamino-pentane, [R-(-)- BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells.2004
- Author(s)
  Maruyama W, Yi H, Takahashi T, Shimazu S, Ohde H, Yoneda K, Iwasa K, Naoi M.
- Journal Title
  
  Life Sci. 75
  
  Pages: 107-117
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase in hibitors : Occurrence, meta- bolism and function in human brains.2004
- Author(s)
  Naoi M, Maruyama W, Nagy GM
- Journal Title
  
  NeuroToxicology 25
  
  Pages: 193-204
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] N-Propargyl-1(R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor(GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kB transcription factor.2004
- Author(s)
  W.Maruyama, A.Nitta, M.Shamoto-Nagai, Y.Hirata, Y.Akao, S.Furukawa, T.Nabeshima, M.Naoi
- Journal Title
  
  Neurochem.Int. 25
  
  Pages: 193-204
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] N-Propargyl-1(R)-aminoindan, rasagiline, increases glial cell line- derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor.2004
- Author(s)
  Maruyama W, Nitta A, Shamoto-Nagai M, Hirata Y, Akao Y, Youdim M, Furukawa S, Nabeshima T, Naoi M.
- Journal Title
  
  Neurochem.Int. 25
  
  Pages: 193-204
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Neuroprotective function of R-(-)-(benzyofuran-2-yl)-2-propylatnino-pentane, R-(-)-BPAP], against apoptosis induced by N-methyl (R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoraa SH-SY5Y cells.2004
- Author(s)
  W.Maruyama, H.Yi, T.Takahashi, S.Shimazu, H.Ohde, K.Yoneda, K.Iwasa, M.Naoi
- Journal Title
  
  Life Sci. 21
  
  Pages: 107-117
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Neuromelanin inhibits enzymatic activity of 26S proteasome in human dopaminergic SH-SY5Y cells.2004
- Author(s)
  Shamoto-Nagai M, Maruyama W, Akao Y, Osawa T, Tribl F, Gerlach M, Zucca FA, Zecca L, Riederer P, Naoi M.
- Journal Title
  
  J.Neural Transm. 111
  
  Pages: 1253-1265
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cells.2003
- Author(s)
  M.Shamoto-Nagai, W.Maruyama, Y.Kato, K.Isobe, M.Tanaka, M.Naoi, T.Osawa
- Journal Title
  
  J.Neurosci.Res. 74
  
  Pages: 589-597
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cells.2003
- Author(s)
  Shamoto-Nagai M, Maruyama W, Kato Y, Isobe K, Tanaka M, Naoi M, Osawa T.
- Journal Title
  
  J.Neurosci.Res. 74
  
  Pages: 589-597
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] The Essentiality of bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroproective-antiapoptotic action of the anti-Parkinson drug, rasagiline.2003
- Author(s)
  MB H.Youdim, T Amit, M.Falach-Yogev, OB.Am, Maruyama W, Naoi M.
- Journal Title
  
  Biochem.Pharmacol. 66
  
  Pages: 1635-1641
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Anti-apoptotic function of propargylamine inhibitors of type-B -monoamine oxidase.2003
- Author(s)
  Naoi M, Maruyama W, M.B.H.Youdim, P.Yu, A.A.Boulton.
- Journal Title
  
  Inflammopharmacology 11
  
  Pages: 175-181
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor2003
- Author(s)
  Maruyama W, M.Weinstock, MBH Youdim, Nagai M, Naoi M.
- Journal Title
  
  Neurosci.Lett. 341(3)
  
  Pages: 233-236
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Anti-apoptotic function of propargylamine inhibitors of type-B-monoamine oxidase.2003
- Author(s)
  M.Naoi, W.Maruyama, M.B.H.Youdira, P.Yu, A.A.Boulton
- Journal Title
  
  Inflammopharmacology 11
  
  Pages: 175-181
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor.2003
- Author(s)
  W.Maruyama, M.Weinstock, MBH Youdim, M.Nagai, M.Naoi
- Journal Title
  
  Neurosci.Lett. 341(3)
  
  Pages: 233-236
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] The Essentiality of bcl-2,PKC and proteasome-ubiquitin complex activations in the neuroproective-antiapoptotic action of the anti-Parkinson drug, rasagiline.2003
- Author(s)
  MB H.Youdira, T Amit, M.Falach-Yogev, OB.Am, W.Maruyama, M.Naoi:
- Journal Title
  
  Biochem.Pharmacol. 66
  
  Pages: 1635-1641
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Mitochondrial Genome Variation in Eastern Asia and the Peopling of Japan.
- Author(s)
  M.Tanaka, V.M.Cabrera, A.M.Gonzalez, J.M.Larruga, T.Takeyasu, N.Fuku, L-J.Guo, R.Hirose, Y.Fujita, M.Kurata, K.Shinoda, K.Umetsu, Y.Yamada, Y.Oshida, Y.Sato, N.Hattori, Y.Mizuno, Y.Arai, N.Hirose, S.Ohta, O.Ogawa, Y.Tanaka, R.Kawamori, M.Shamoto-Nagai, W.Maruyama, H.Shimokata, R.Suzuki, H.Shimodaira
- Journal Title
  
  Genome Res. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Mitochondrial Genome Variation in Eastern Asia and the Peopling of Japan.
- Author(s)
  Tanaka M, V.M.Cabrera, A.M.Gonzalez, J.M.Larruga, Takeyasu T, Fuku N, L-J.Guo, Hirose R, Fujita Y, Kurata M, Shinoda K, Umetsu K, Yamada Y, Oshida Y, Sato Y, Hattori N, Mizuno Y, Arai Y, Hirose N, Ohta S, Ogawa O, Tanaka Y, Kawamori R, Shamoto-Nagai M, Maruyama W, Shimokata H, Suzuki R, Shimodaira H.
- Journal Title
  
  Genome Res. In press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Monoamine oxidase and the inhibitors : Involvement in cell death and survival of neurons.
- Author(s)
  M.Naoi, W.Maruyama
- Journal Title
  
  Milestones in monoamine research. (I Lorok Tl (ed))(Medicina Publishing House, Budapest) (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Oxidative stress in mitochondrial : The involvement in neurodegene-ative diseases.
- Author(s)
  M.Naoi, W.Maruyama, M.Shamoto-Nagai, Y.Kato, M.Tanaka
- Journal Title
  
  The involvement in neurodegeneative diseases. Inflammation and Health(Surh Y-J. (ed)) (Mercel Dekker, New York, Oxidative Stress) (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Journal Article] Neuroprotection by rasagiline, N-propargyl-1R(+)-aminoindan, and related propargylamines is mediated by suppression of mitochondrial death signal and induction of anti-apoptotic genes.
- Author(s)
  W.Maruyama, Y.Akao, A.Nitta, M.Naoi
- Journal Title
  
  Inflammation and Health(Surh Y-J. (ed)) (Mercel Dekker, New York, Oxidative Stress) (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590925
[Presentation] 認知症予防のための栄養学的介入の試み2024
- Author(s)
  丸山和佳子
- Organizer
  神経科学研究会
- Data Source
  KAKENHI-PROJECT-21K07402
[Presentation] 口腔内炎症のパーキンソン病発症に及ぼす影響2023
- Author(s)
  永井雅代、平山正昭、直井信、丸山和佳子
- Organizer
  日本神経化学会
- Data Source
  KAKENHI-PROJECT-21K07402
[Presentation] 高齢者のフレイルと認知症に関する最近の話題2023
- Author(s)
  丸山和佳子
- Organizer
  全国歯科衛生士教育協議会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07402
[Presentation] 緑茶カテキンによる唾液中myeloperoxidaseの阻害機構（2-II-15）2022
- Author(s)
  永井雅代、直井信、丸山和佳子
- Organizer
  第74回日本ビタミン学会
- Data Source
  KAKENHI-PROJECT-21K07402
[Presentation] 老化に関する最近の話題2022
- Author(s)
  丸山和佳子
- Organizer
  第19回高付加価値食品開発のためのフォーラム　(日本食品・機械研究会)
- Invited
- Data Source
  KAKENHI-PROJECT-21K07402
[Presentation] 神経変性疾患に対する栄養学的先制医療の可能性について2022
- Author(s)
  丸山和佳子
- Organizer
  第19回　神経科学研究会
- Data Source
  KAKENHI-PROJECT-21K07402
[Presentation] 健康寿命を伸ばす栄養のヒント2022
- Author(s)
  丸山和佳子
- Organizer
  なごや健康カレッジ
- Invited
- Data Source
  KAKENHI-PROJECT-21K07402
[Presentation] Traditional Japanese medicine in anxiety and depression2022
- Author(s)
  Makoto Naoi, Wakako Maruyama and Masayo Shamoto-Nagai
- Organizer
  World Association for Stress Related and Anxiety Disorders
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07402
[Presentation] Neurotrophic function of phytochemicals in synucleinopathies2022
- Author(s)
  Makoto Naoi and Wakako Maruyama
- Organizer
  Clinical Neurochemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07402
[Presentation] Traditional Japanese Medicine, Kampo, in anxiety and depression.2021
- Author(s)
  Naoi M, Maruyama W, Shamoto-Nagai M.
- Organizer
  The 3rd International Congress of the World Association for Stress Related and Anxiety Disorders (WASAD)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07402
[Presentation] Involvement of Foxo3a in neuronal and cognitive functions in mice2020
- Author(s)
  Maruyama H, Izuo N,, Yamada K., Wang F., Uno K., Noboru Motoyama N., Maruyama W., Nitta A.
- Organizer
  36th International Annual Meeting in Pharmaceutical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07430
[Presentation] 緑茶カテキン類はmyeloperoxidaseを阻害することで口腔内炎症を抑制する2020
- Author(s)
  永井雅代、三瀬奏絵、湊春菜、西口寛一朗、直井信、丸山和佳子
- Organizer
  日本ビタミン学会
- Data Source
  KAKENHI-PROJECT-18K07430
[Presentation] Epigallocatechin gallate (EGCG)はドパミンによる神経細胞死を増強する2019
- Author(s)
  永井雅代、松島由来、山下桃花、直井信、丸山和佳子
- Organizer
  第70回日本ビタミン学会
- Data Source
  KAKENHI-PROJECT-18K07430
[Presentation] 老化を遅延させるストラテジーとは？：口腔内慢性炎症制御について2019
- Author(s)
  丸山和佳子
- Organizer
  神経科学研究会
- Data Source
  KAKENHI-PROJECT-18K07430
[Presentation] Myeloperoxidase (MPO)は歯周病の定量的評価に有用である;老年病発症リスクとの関連2019
- Author(s)
  西口寛一朗、丸山和佳子、永井雅代、直井信、野内美邑、中村早希、小島規永、武部　純
- Organizer
  日本口腔ケア学会
- Data Source
  KAKENHI-PROJECT-18K07430
[Presentation] Role of type A and B monoamine oxidase in expression of pro-survival genes in neuroblastoma SH-SY5Y and glioblastoma U118MG cells2019
- Author(s)
  Masayo Shamoto-Nagai, Keiko Inaba-Hasegawa, Wakako Maruyama, Makoto Naoi
- Organizer
  日本神経化学会
- Data Source
  KAKENHI-PROJECT-18K07430
[Presentation] Quantitative analysis of myeloperoxidase (MPO) and brain-derived neurotrophic factor (BDNF) in plasma and saliva in aged2018
- Author(s)
  Masayo Shamoto-Nagai, Kanichiro Nishiguchi, Norinaga Kojima, Jun Takebe, Makoto Naoi, Wakako Maruyama
- Organizer
  日本神経化学大会
- Data Source
  KAKENHI-PROJECT-18K07430
[Presentation] 超高齢社会における認知症とオーラルフレイルに関する最新の知見2018
- Author(s)
  丸山和佳子
- Organizer
  日本補綴歯科学会　支部学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07430
[Presentation] Accumulated oxidative injury in neuronal ageing and Parkinson disease2018
- Author(s)
  Wakako Maruyama
- Organizer
  日本神経化学大会
- Data Source
  KAKENHI-PROJECT-18K07430
[Presentation] 口腔昨日低下症患者における唾液および血液中ミエロペルオキシダーゼ(MPO)の検討2018
- Author(s)
  西口寛一朗、小島規永、永井雅代、藤波和華子、田中茂生、丸山和佳子、武部純
- Organizer
  日本補綴歯科学会　支部学術大会
- Data Source
  KAKENHI-PROJECT-18K07430
[Presentation] Propanoylation of amyloid β is the key post-translational modification to enhance its aggregability and neurotoxicity in Alzheimer’s disease2014
- Author(s)
  Shinsuke Hisaka, Yoshimi Hayashi, Hiroyasu Akatsu, Masayo Shamoto-Nagai, Yoji Kato, Mitsuhiko Nose, Wakako Maruyama, Toshihiko Osawa
- Organizer
  17th Biennial Meeting of Society for Free Radical Research International
- Place of Presentation
  国立京都国際会館（京都市）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] Alpha-synuclein の主たる分解系はautophagyであるが、脂質酸化ストレス下では他の分解系が活性化される。2013
- Author(s)
  永井雅代、日坂真輔、大澤俊彦、直井信、南山誠、本山昇、丸山和佳子
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] DHA increases abnormal alpha-synuclein and perturbs ubiquitin proteasome system.(多価不飽和脂肪酸はドーパミン神経細胞の過酸化およびリン酸化alpha-synucleinを増加させるとともにubiquitin proteasome systemの機能を低下させる。)2013
- Author(s)
  Shamoto-Nagai Masayo, Hisaka Shinsuke, Osawa Toshihiko, Naoi Makoto, Kurokawa-Nose Yumi, Maruyama Wakako.
- Organizer
  Neuro2013
- Place of Presentation
  国立京都国際会館（京都市）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] Modification of a-synuclein by lipidperoxide derived from PUFA.2013
- Author(s)
  Nagai-Shamoto M., Hisaka S., Osawa T., Naoi M, Nose-Kurokawa Y., Maruyama W.
- Organizer
  Neuro2013
- Place of Presentation
  国立京都国際会館（京都市）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] The creation trial of the new Lewy body disease model considered aging.2013
- Author(s)
  Minamiyama M., Long N., Nose Y., Motoyama M., Shamoto-Nagai M., Ibaraki K., Hayakawa T., Yamada Y., Naoi M., Maruyama W.
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego（アメリカ合衆国）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] Development of new antibody array and its application to evaluate anti-dementia drugs.2013
- Author(s)
  Maruyama W., Shamoto-Nagai M., Naoi M., Takatsu Y., Wu X.
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego（アメリカ合衆国）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] Interaction of type A monamine oxidase with type B monoamine oxidase.2013
- Author(s)
  Naoi　M., Inaba-Hasegawa K., Maruyama W.
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego（アメリカ合衆国）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] 加齢を考慮したレビー小体病モデルの検討2013
- Author(s)
  南山　誠、龍　訥、能勢　弓、本山　昇、永井雅代、茨木京子、早川智久、山田洋美、直井　信、丸山和佳子
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] Modification of alpha-synuclein by lipidperoxide derived from PUFA-The relevance of cell death in PD.2013
- Author(s)
  Shamoto-Nagai M., Hisaka S., Osawa T., Naoi M., Maruyama W.
- Organizer
  第５回NAGOYAグローバルリトリート
- Place of Presentation
  愛知健康プラザ（愛知県）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] DHA peroxidation induced neural cell death_but alpha-synuclein play a neuroprotective role with proteolysis system in SH-SY5Y cells overexpressed alpha-synuclein.2013
- Author(s)
  Shamoto-Nagai M., Hisaka S., Osawa T., Naoi M., Kurokawa-Nose Y., Maruyama W.
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego（アメリカ合衆国）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] Modification of alpha-synuclein by lipidperoxide derived from PUFA.2012
- Author(s)
  Shamoto-Nagai M., Shinsuke H., Osawa T., Naoi M., Kurokawa-Nose Y., Maruyama W.
- Organizer
  Society for Neuroscience
- Place of Presentation
  ニューオリンズ（米国）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] 食品由来成分による高齢者認知症に対する介入の試み2012
- Author(s)
  永井雅代、直井信、丸山和佳子
- Organizer
  フォーラム2012　衛生薬学・環境トキシコロジー学会
- Place of Presentation
  名古屋観光ホテル（愛知県）
- Invited
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] 加齢に伴う認知症の環境要因による制御の可能性2012
- Author(s)
  丸山和佳子
- Organizer
  フォーラム2012　衛生薬学・環境トキシコロジー学会
- Place of Presentation
  名古屋観光ホテル（愛知県）
- Invited
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] Induction of GDNF and neurotrophins by rasagiline and selegiline: Regulation by type B monoamine oxidase2012
- Author(s)
  Inaba-Hasegawa K., Maruyama W., Shamoto-Nagai M., Naoi M.
- Organizer
  Asia-Pasific Society for Neurochemistry
- Place of Presentation
  神戸コンベンションセンター（兵庫県）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] Induction of GDNF and neurotrophins by rasagiline and selegiline.2012
- Author(s)
  Inaba-Hasegawa K., Naoi M., Shamoto-Nagai M., Maruyama W
- Organizer
  Society for Neuroscience
- Place of Presentation
  ニューオリンズ（米国）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] アミロイドβタンパク質における脂質過酸化に由来する翻訳後修飾による細胞毒性発現機構の解析2012
- Author(s)
  日坂真輔、林佳美、赤津裕康、永井雅代、加藤陽二、能勢充彦、丸山和佳子、大澤俊彦
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] alpha-synucleinは脂質過酸化ストレスによるドパミン神経細胞死を抑制し、毒性をもつ異常構造体を生成する2012
- Author(s)
  永井雅代、日坂真輔、大澤俊彦、直井信、丸山和佳子
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] Chicken extracts containing imidazole dipeptide, L-carnosine and L-anserine increase brain-derived neurotrophic factor (BDNF) and mental performance in the aged.2012
- Author(s)
  Maruyama W., Shamoto-Nagai M., Nagaya M., Naoi M., Sato M., Miyaji T., Morimatsu F.
- Organizer
  Society for Neuroscience
- Place of Presentation
  ニューオリンズ（米国）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] 脳髄液中に含まれるN結合型糖鎖解析2012
- Author(s)
  小池崇子、吉村武、文堂昌彦、丸山和佳子、池中一裕
- Organizer
  第85回日本生化学会
- Place of Presentation
  福岡県、福岡国際会議場
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-24659287
[Presentation] 多価不飽和脂肪酸は酸化ストレスを介して神経変性疾患を惹起しうるか2012
- Author(s)
  日坂真輔、林佳美、赤津裕康、永井雅代、加藤陽二、能勢充彦、丸山和佳子、大澤俊彦
- Organizer
  フォーラム2012　衛生薬学・環境トキシコロジー学会
- Place of Presentation
  名古屋観光ホテル（愛知県）
- Invited
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] Modification of α-synuclein by lipid peroxide derived from PUFA.2012
- Author(s)
  Shamoto-Nagai M., Hisaka S., Osawa T., Naoi M., Nose Y., Maruyama W.
- Organizer
  Asia-Pasific Society for Neurochemistry
- Place of Presentation
  神戸コンベンションセンター（兵庫県）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] 脳脊髄液に含まれるN結合型糖鎖構造解析2012
- Author(s)
  小池崇子、吉村武、文堂昌彦、丸山和佳子、池中一裕
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] CADASILモデルとしての変異NOTCH3ノックインマウスの作成と解析2010
- Author(s)
  國本正子、渡辺淳、足立香代、松崎三記子、武田和也、脇田英明、Rajesh N.Kalaria、丸山和佳子、高橋憲吉
- Organizer
  Neuro2010 第20回日本神経科学会
- Place of Presentation
  神戸
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] B型モノアミン酸化酵素阻害剤による神経保護剤による神経保護の機序にはモノアミン酸化酵素が関与する2010
- Author(s)
  稲葉桂子、直井信、丸山和佳子、永井雅代
- Organizer
  Neuro2010 第53回日本神経化学会
- Place of Presentation
  神戸
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] 生体内脂質過酸化による酸化傷害機構の化学的解明2010
- Author(s)
  日坂真輔、林佳美、加藤陽二、赤津裕康、丸山和佳子、大澤俊彦
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] ヒト変異Notch3重合体の分解促進剤のスクリーニング2010
- Author(s)
  渡邉淳、足立香代、國本正子、武田和也、脇田英明、丸山和佳子、高橋慶吉
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] Propanoylation of amyloid b is trigger to the aggregation and enhanced its neurotoxicity.2010
- Author(s)
  Shinsuke Hisaka, Yoshimi Hayashi, Masayo Shamoto-Nagai, Yoji Kato, Hiroyasu Akatsu, Mitsuhiko Nose, Wakako Maruyama, Toshihiko Osawa
- Organizer
  Society for Free Radical Biology and Medicine (SFRBM)'s 17th Annual Meeting
- Place of Presentation
  Orlando, Florida, USA
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] Alpha-synuclein modified by lipid peroxide derived from DHA oxidation enhances the cytotoxicity to Dopaminergic neurons2010
- Author(s)
  永井雅代, 丸山和佳子, 大澤俊彦
- Organizer
  グローバルCOE第2回NAGOYAグローバルリトリート
- Place of Presentation
  Kobe, Japan.
- Year and Date
  2010-02-26
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] Hutchson-Gilford Progeria Syndromeモデルマウスの寿命制御におけるChk2を介したDNA損傷応答の関与2010
- Author(s)
  大矢恵、鈴木今日子、大田久美子、早川智久、Stephen G Young、丸山和佳子、本山昇
- Organizer
  BMB2010(第33回日本分子生物学会年会、第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] Selective dephosphorylation of FOXO by PP2A mediates cellular oxidative stress response.2010
- Author(s)
  Yanagino T, Furukawa-Hibi Y, Iemura S, Natsume T, Watanabe K, Maruyama W, Motoyama N
- Organizer
  Cold Spring Harbor Laboratory Meeting on "Molecular Genetics of Aging"
- Place of Presentation
  Cold Spring Harbor, NY, USA
- Year and Date
  2010-09-30
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] The role of lipid peroxidation in ageing-related neurodegeneration, and the possible prevention by food factors.2010
- Author(s)
  Wakako Maruyama
- Organizer
  The Second Workshop on Beneficial Marine Lipids as Ingredients for Functional Foods
- Place of Presentation
  Wellington New Zealand.
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] Alpha-synucleinは不飽和脂肪酸による酸化ストレス障害を抑制することでドパミン神経を保護する2010
- Author(s)
  永井雅代、能勢弓、直井信、大澤俊彦、丸山和佳子
- Organizer
  BMB2010(第33回日本分子生物学会年会、第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] 抗体チップを用いた尿中酸化ストレスマーカーの測定2010
- Author(s)
  星野文彦、渡辺修、呉暁紅、瀧本陽介、竹内征夫、丸山和佳子、大澤俊彦
- Organizer
  BMB2010(第33回日本分子生物学会年会、第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] Role of ageing on the pathogenesis of neurodegeneration2010
- Author(s)
  Wakako Maruyama
- Organizer
  First Workshop on Beneficial Marine Lipids as Ingredients for Functional Foods.
- Place of Presentation
  東京
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] 酸化ストレスによるフォークヘッド型転写因子FOXOの活性化メカニズムの解析2010
- Author(s)
  柳野卓也、日比陽子、伊藤雄貴、家村俊一郎、夏目徹、渡辺研、丸山和佳子、本山昇
- Organizer
  第33回日本基礎老化学会
- Place of Presentation
  名古屋
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] 不飽和脂肪酸は神経芽細胞腫SH-SY5Y細胞の酸化ストレスと細胞死を誘導する2010
- Author(s)
  永井雅代、能勢弓、直井信、丸山和佳子
- Organizer
  Neuro2010 第53回日本神経化学会
- Place of Presentation
  神戸
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] Immunological detection of propanoy1-1ysine produced by reaction of lysine with oxidized omega-3 polyunsaturated fatty acids in vivo.2009
- Author(s)
  Shinsuke Hisaka, Yoji Kato, Wakako Maruyama, Toshihiko Osawa
- Organizer
  The Societies For Free Radical Research Australasia and Japan
- Place of Presentation
  Sydney, Austria
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] Alpha-synuclein modified by lipid peroxide derived from DHA oxidation enhances the cytotoxicity to Dopaminergic neurons2009
- Author(s)
  Masayo Shamoto-Nagai, Toshihiko Osawa, Wakako Maruyama
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  Kobe, Japan.
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] Immunological detection of Ne-propanoy1-1ysine produced by reaction of lysine with oxidized w-3 polyunsaturated fatty acidsin vivo.2009
- Author(s)
  日坂真輔、加藤陽二、丸山和佳子、大澤俊彦
- Organizer
  グローバルCOE第2回国際シンポジウム
- Place of Presentation
  Nagoya, Japan.
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] 生体内脂質過酸化による酸化傷害機構の化学的解明2009
- Author(s)
  日坂真輔、林佳美、加藤陽二、赤津裕康、丸山和佳子、大澤俊彦
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  Kobe, Japan.
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] DHA由来の脂質過酸化物によるα-シヌクレイン修飾は神経細胞に対する毒性を増加させる2009
- Author(s)
  永井雅代, 丸山和佳子, 日坂真輔, 直井信, 大澤俊彦
- Organizer
  グローバルCOE第2回国際シンポジウム
- Place of Presentation
  Nagoya, Japan.
- Data Source
  KAKENHI-PROJECT-21650184
[Presentation] Role of lipid peroxide derived from PUFA in the conformational change of alpha-synuclein and cell death in Parkinson disease.
- Author(s)
  Maruyama W., Shamoto-Nagai M., Naoi M., Hisaka S., Osawa T., Minamiyama M., Motoyama N.
- Organizer
  Society for Neuroscience
- Place of Presentation
  ワシントンDC(アメリカ合衆国）
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] alpha-synuclein は細胞内の活性酸素産生を低下させ、タンパク分解系を活性化することで神経細胞を保護している
- Author(s)
  永井雅代、日坂真輔、大澤俊彦、直井信、南山誠、本山昇、丸山和佳子
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] alpha-synuclein 過剰発現細胞では脂質過酸化ストレス下でタンパク分解系が活性化する
- Author(s)
  永井雅代、直井信、大澤俊彦、丸山和佳子
- Organizer
  第57回日本神経化学会
- Place of Presentation
  奈良県文化会館（奈良県）
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] 鶏肉由来ジペプチド、カルノシンによる高齢者認知症に対する介入研究の試み
- Author(s)
  山岡朗子、永井雅代、南山誠、長屋政博、鷲見幸彦、丸山和佳子
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Year and Date
  2014-05-21 – 2015-05-24
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] DHA induces the dysfunction of cellular proteolysis system and the formation of alpha-synuclein aggregates in SH-SY5Y cells.
- Author(s)
  Shamoto-Nagai M., Naoi M., Osawa T., Motoyama N., Minamiyama M., Maruyama W.
- Organizer
  Society for Neuroscience
- Place of Presentation
  ワシントンDC(アメリカ合衆国）
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24248024
[Presentation] Rasagiline prevents calcium release and apoptosis by opeining mitochondrial permeability transition pore; Assayed by a novel measurement for cytoplasmic calcium.
- Author(s)
  Wu Y., Kazumura K., Osawa T., Maruyama W., Naoi M.
- Organizer
  Society for Neuroscience
- Place of Presentation
  ワシントンDC(アメリカ合衆国）
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24248024

1. OSAWA TOSHIHIKO (00115536)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
2. KATO Yoji (30305693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. HISAKA Shinsuke (60583838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
4. IKENAKA Kazuhiro (00144527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. BUNDO Masahiko (10426497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. YOSHIMURA Takeshi (60402567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 中村宜督 (60324381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Maruyama Wakako 丸山 和佳子

MARUYAMA Wakako 丸山 和佳子

丸山 和佳子 マルヤマ ワカコ

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Oral inflammation induces Parkinson disease via production of oxidized synucleinPrincipal Investigator

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Membrane lipid peroxidation is involved in the pathogenesis of Parkinson diseasePrincipal Investigator

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Establishment and application of evaluation system of brain aging using alkyl-amide adducts as probe

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Development of a technology to analyze total N-glycans contained in cerebrospinal fluid

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老化シグナルを制御し、神経変性を予防する食品成分の開発Principal Investigator

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Establishment of oxidative stress biomarkers in regulation of brain-aging and protective role of antioxidative food factors

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Development of a drug, which can pass the blood-brain barrier and induces neuroprotective proteins in the brain.Principal Investigator

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孤発性パーキンソン病の神経細胞変性の機序;ミトコンドリアにおける細胞死制御機構Principal Investigator

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THE MECHANISM OF NEURONAL AGING : THE INACTIVATION AND CONFORMATIONAL CHANGE OF PROTEINS BY OXIDATIVE MODIFICATIONPrincipal Investigator

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[Book] Lipid Hydroperoxide-Derived Modification of Biomolecules（Subcellular Biochemistry 77)2014

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[Book] A Handbook of Neurotoxicity2013

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[Book] Current Topics in Medical Chemistry2013

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[Book] アスタキサンチンの機能と応用2012

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[Book] 機能性食品・素材と運動療法ー生活習慣病予防と運動機能維持、向上をめざしてー2012

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Maruyama Wakako 丸山和佳子

MARUYAMA Wakako 丸山和佳子

丸山和佳子マルヤマワカコ