Saito Sakae 齋藤さかえ

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SAITO Sakae 齋藤さかえ

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Researcher Number	20335491
Other IDs
Affiliation (Current)	2025: 東北大学, 未来型医療創成センター, 講師 2025: 東北大学, 東北メディカル・メガバンク機構, 講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 東北大学, 未来型医療創成センター, 講師 2013 – 2020: 東北大学, 東北メディカル・メガバンク機構, 講師 2011 – 2012: 京都大学, 医学(系)研究科(研究院), 研究員 2009: Japanese Foundation For Cancer Research, 癌化学療法センターゲノム研究部, 研究員 2009: Japanese Foundation For Cancer Research, 癌化学療法センター, 研究員 2008: Japanese Foundation For Cancer Research, 癌化学療法センター・ゲノム研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Pharmacology in pharmacy / Tumor biology / General pharmacology Except Principal Investigator Basic Section 56010:Neurosurgery-related / Tumor diagnostics / Digestive surgery
Keywords	Principal Investigator 小胞体ストレス / 癌 / マイクロバイオーム / ストレス / 腫瘍微小環境 / 抗がん剤 / マイクロアレイ / 分子標的薬 / 創薬 Except Principal Investigator 微小環境 … More / メチル化 / 放射線治療 / テモゾロミド / 腸内細菌 / 膠芽腫 / ゲノム解析 / 全ゲノム解読 / 一般住民 / がん関連遺伝子 / 有害変異 / 家族性乳がん卵巣がん症候群 / 前向きゲノムコホート / VUS / がん素因遺伝子 / 免疫学 / 外科 / 癌 / TCRレパトア / 治療効果 / 免疫多様性 / T細胞受容体 / 放射線化学療法 / レパトア解析 / T細胞受容体遺伝子 / 予後予測因子 / 腫瘍免疫 / 化学放射線療法 / 食道癌 Less

腸内・腫瘍内細菌叢による膠芽腫治療の新機軸
- Principal Investigator
  
  金森政之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Tohoku University
Elucidating the pathogenic mechanisms of systemic diseases associated with oral microbiomePrincipal Investigator
- Principal Investigator
  
  Saito Sakae
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tohoku University
Analyses of effects of variants with uncertain significance in the cancer related genes on the carcinogenesis in general population
- Principal Investigator
  
  Yasuda Jun
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
  Tohoku University
T-Cell Receptor repertoire analyses in patients with esophageal cancer
- Principal Investigator
  
  Mori Takahiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Analysis and modeling of the effect of microenvironment on tumor growth.Principal Investigator
- Principal Investigator
  
  SAITO Sakae
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Tohoku University
Characterization of the unfolded protein response (UPR) modulatorsin solid tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  SAITO Sakae
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kyoto University
In silico screening and characterization of modulators of the unfolded protein response (UPR)Principal Investigator
- Principal Investigator
  
  SAITO Sakae
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Japanese Foundation For Cancer Research

[Book] マイクロアレイを用いた遺伝子発現解析2009
- Author(s)
  齋藤さかえ, 冨田章弘
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] A global phylogenetic analysis of Japanese tonsil-derived Epstein-Barr virus strains using viral whole-genome cloning and long-read sequencing2021
- Author(s)
  Yajima Misako、Kakuta Risako、Saito Yutaro、Kitaya Shiori、Toyoda Atsushi、Ikuta Kazufumi、Yasuda Jun、Ohta Nobuo、Kanda Teru
- Journal Title
  
  Journal of General Virology
  
  Volume: 102 Issue: 3
- DOI
  10.1099/jgv.0.001549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09184, KAKENHI-PROJECT-20K08213, KAKENHI-PROJECT-19H03795, KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-18K10057, KAKENHI-PROJECT-16H06279
[Journal Article] Analysis of HLA-G long-read genomic sequences in mother?offspring pairs with preeclampsia2020
- Author(s)
  Nishizawa Ayako、Kumada Kazuki、Tateno Keiko、Wagata Maiko、Saito Sakae、Katsuoka Fumiki、Mizuno Satoshi、Ogishima Soichi、Yamamoto Masayuki、Yasuda Jun、Sugawara Junichi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 20027-20027
- DOI
  10.1038/s41598-020-77081-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11545, KAKENHI-PROJECT-19H03795, KAKENHI-PROJECT-17K07193
[Journal Article] Identification of genetic alterations in extramammary Paget disease using whole exome analysis2019
- Author(s)
  Kiniwa Yukiko、Yasuda Jun、Saito Sakae、Saito Rumiko、Motoike Ikuko N.、Danjoh Inaho、Kinoshita Kengo、Fuse Nobuo、Yamamoto Masayuki、Okuyama Ryuhei
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 94 Issue: 1 Pages: 229-235
- DOI
  10.1016/j.jdermsci.2019.03.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-17H04240
[Journal Article] Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing2018
- Author(s)
  Mimori T, Fumiki K, Sakae S、Naoki N, 、Akira O, Minegishi N, Kinoshita K, Nagasaki M, Yamamoto M
- Journal Title
  
  Pharmacogenomics
  
  Volume: 63 Issue: 2 Pages: 213-230
- DOI
  10.1038/s41397-017-0010-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09464, KAKENHI-PROJECT-17K17589, KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-16K10488, KAKENHI-PROJECT-18H02940
[Journal Article] Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing2017
- Author(s)
  Shibuya Yusuke、Tokunaga Hideki、Saito Sakae、Shimokawa Kazurou、Katsuoka Fumiki、Bin Li、Kojima Kaname、Nagasaki Masao、Yamamoto Masayuki、Yaegashi Nobuo、Yasuda Jun
- Journal Title
  
  Genes Chromosomes Cancer.
  
  Volume: 57 Issue: 2 Pages: 51-60
- DOI
  10.1002/gcc.22507
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-15H04978, KAKENHI-PROJECT-16K10488
[Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds.2013
- Author(s)
  Ushijima M, Mashima T, Tomida A, Dan S, Saito S, Furuno A, Tsukahara S, Seimiya H, Yamori T, Matsuura M.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104(3) Issue: 3 Pages: 360-368
- DOI
  10.1111/cas.12071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240092, KAKENHI-PROJECT-22300341, KAKENHI-PROJECT-23501319, KAKENHI-PROJECT-23701067, KAKENHI-PROJECT-24240042, KAKENHI-PROJECT-24650626, KAKENHI-PROJECT-24650639, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25290061, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-23117527
[Journal Article] Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling2012
- Author(s)
  Saito S, Furuno A, Sakurai J, Park HR, Shin-ya K, Tomida A
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 9 Pages: e45845-e45845
- DOI
  10.1371/journal.pone.0045845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300342, KAKENHI-PROJECT-23701067, KAKENHI-PROJECT-24650626
[Journal Article] Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions2010
- Author(s)
  Naomi Haga, Sakae Saito, Yoshinori Tsukumo, Junko Sakurai, Aki Furuno, Takashi Tsuruo, Akohiro Tomida
- Journal Title
  
  Cancer Science Vol.101,No.5
  
  Pages: 1125-1132
- NAID
  10026591912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site2009
- Author(s)
  Yoshinori Tsukumo, Satomi Tsukahara, Sakae Saito, Takashi Tsuruo, Akihiro Tomida
- Journal Title
  
  J Biol Chem. Vol.284,No.40
  
  Pages: 27500-27510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation2009
- Author(s)
  Sakae Saito, Aki Furuno, Junko Sakurai, Asami Sakamoto, Hae-Ryong Park, Kazuo Shin-ya, Takashi Tsuruo, Akihiro Tomida
- Journal Title
  
  Cancer Research Vol.69,No.10
  
  Pages: 4225-4234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation.2009
- Author(s)
  Sakae Saito, et. Al.
- Journal Title
  
  Cancer Research 69
  
  Pages: 4225-4234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] がんにおける小胞体ストレス-UPRを標的とした抗がん剤の開発2009
- Author(s)
  齋藤さかえ, 冨田章弘
- Journal Title
  
  最新医学 64巻
  
  Pages: 242-250
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] 小胞体ストレス応答を標的とした癌治療2009
- Author(s)
  齋藤さかえ, 冨田章弘
- Journal Title
  
  実験医学 27巻,2号
  
  Pages: 298-304
- Data Source
  KAKENHI-PROJECT-20790217
[Journal Article] 小胞体ストレスとがん治療2008
- Author(s)
  齋藤さかえ, 冨田章弘
- Journal Title
  
  Cancer Frontier 10巻
  
  Pages: 26-31
- NAID
  40016270403
- Data Source
  KAKENHI-PROJECT-20790217
[Presentation] Integrated genomic characterization of non-small cell lung cancer cell lines.2016
- Author(s)
  Saito, S., Motoike, I.N., Kinoshita, K., Yasuda, J., Ishii, H., Yamamoto, M.
- Organizer
  Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research
- Place of Presentation
  Maui, Hawaii USA
- Year and Date
  2016-02-16
- Data Source
  KAKENHI-PROJECT-25460097
[Presentation] 腫瘍内細胞のシングルセル解析2015
- Author(s)
  齋藤さかえ、永山勝也
- Organizer
  NGS現場の会第4回研究会
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2015-07-01
- Data Source
  KAKENHI-PROJECT-25460097
[Presentation] 統合オミクス解析に向けた非小細胞肺がん細胞株のゲノム多型解析2015
- Author(s)
  齋藤さかえ、元池育子、潘小青、齊藤智、齋藤るみ子、檀上稲穂、鈴木隆史、本橋ほづみ、木下賢吾、安田純、石井啓文、山本雅之
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460097
[Presentation] Particle simulation of cancer growth and angiogenesis ─ based on the image of mouse2014
- Author(s)
  Hiroto Tanaka, Yuki Oshiumi, Katsuya Nagayama, Ichiro Miura, Sakae Saito
- Organizer
  The Second BMIRC International Symposium on Advances in Bioinformatics and Medical Engineering: In Memory of Professor Akinori Sarai
- Place of Presentation
  福岡県立飯塚研究開発センター（福岡県飯塚市）
- Data Source
  KAKENHI-PROJECT-25460097
[Presentation] 腫瘍増殖の3次元粒子シミュレーション－細胞増殖と血管新生の相互作用モデル2013
- Author(s)
  永山勝也, 三浦一郎, 齋藤さかえ, 立野玲子, 小倉潔
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-25460097
[Presentation] Dorsomorphin はグルコース飢餓により誘導される小胞体ストレス応答を阻害する2011
- Author(s)
  齋藤さかえ、新家一男、冨田章弘
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-23701067
[Presentation] グルコース飢餓環境下における小胞体ストレス応答(UPR)制御薬剤の作用機序の解析2011
- Author(s)
  齋藤さかえ、芳賀直実、築茂由則、新家一男、冨田章弘
- Organizer
  第15回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-23701067
[Presentation] Gene expression -based analysis identifies the unfolded protein response as a target for selective cancer cell killing2010
- Author(s)
  Sakae Saito, et, al.
- Organizer
  8th AACR-JCA Joint Conference
- Place of Presentation
  Hilton Waikoloa Village (Hawaii, U.S. )
- Year and Date
  2010-02-08
- Data Source
  KAKENHI-PROJECT-20790217
[Presentation] Gene expression-based analysis identifies the unfolded protein response as a target for selective cancer cell killing2010
- Author(s)
  齋藤さかえ, 他
- Organizer
  8th AACR-JCA Joint Conference
- Place of Presentation
  Hilton Waikoloa Village(Hawaii, USA)
- Year and Date
  2010-02-08
- Data Source
  KAKENHI-PROJECT-20790217
[Presentation] 遺伝子発現プロファイルを利用した小胞体ストレス応答制御薬剤の探索2009
- Author(s)
  齋藤さかえ, 他
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20790217
[Presentation] インシリコスクリーニングによる小胞体ストレス応答制御薬剤の探索2009
- Author(s)
  齋藤さかえ、他
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテルクレメント徳島
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-20790217
[Presentation] インシリコスクリーニングによる小胞体ストレス応答制御薬剤の探索2009
- Author(s)
  齋藤さかえ, 他
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテルクレメント徳島(徳島県)
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-20790217
[Presentation] 腫瘍成長と血管新生の3D粒子シミュレーション -壊死に関する研究-
- Author(s)
  永山勝也, 齋藤さかえ, 三浦一郎, 立野玲子, 小倉潔
- Organizer
  日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460097
[Presentation] Particle Simulation on Cancer Growth and Angiogenesis- Modeling of stromal cells
- Author(s)
  Yukio Nagamizu, Youhei Tajima, Katsuya Nagayama, Ichiro Miura, Sakae Saito
- Organizer
  The Third BMIRC International Symposium for Virtual Physiological Human
- Place of Presentation
  のがみプレジデントホテル（福岡県飯塚市）
- Year and Date
  2015-03-05 – 2015-03-06
- Data Source
  KAKENHI-PROJECT-25460097
[Presentation] RNA sequencing and whole transcriptome analysis of tumor-associated monocytes.
- Author(s)
  Sakae Saito
- Organizer
  Joint Meeting of the 1st Africa International Biotechnology & Biomedical Conference and the 8th International Workshop on Approaches to Single-Cell Analysis
- Place of Presentation
  Safari Park Hotel (Nairobi, Kenya)
- Year and Date
  2014-09-09 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-25460097
[]
[]

1. Yasuda Jun (00281684)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. TOMIDA Akihiro (40251483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. NAGAYAMA Katsuya (70363398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. Mori Takahiro (00323030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 金森政之 (60420022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 山下理宇 (10401259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 信國宇洋 (30731674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 下田由輝 (30815444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 矢守隆夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 旦慎吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 椎名勇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 荻島創一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 峯岸直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 神田輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saito Sakae 齋藤 さかえ

SAITO Sakae 齋藤 さかえ

Research Projects

Research Products

Co-Researchers

腸内・腫瘍内細菌叢による膠芽腫治療の新機軸

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the pathogenic mechanisms of systemic diseases associated with oral microbiomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyses of effects of variants with uncertain significance in the cancer related genes on the carcinogenesis in general population

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

T-Cell Receptor repertoire analyses in patients with esophageal cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis and modeling of the effect of microenvironment on tumor growth.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of the unfolded protein response (UPR) modulatorsin solid tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In silico screening and characterization of modulators of the unfolded protein response (UPR)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] マイクロアレイを用いた遺伝子発現解析2009

Author(s)

Publisher

Data Source

[Journal Article] A global phylogenetic analysis of Japanese tonsil-derived Epstein-Barr virus strains using viral whole-genome cloning and long-read sequencing2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of HLA-G long-read genomic sequences in mother?offspring pairs with preeclampsia2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of genetic alterations in extramammary Paget disease using whole exome analysis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds.2013

Author(s)

Journal Title

DOI

Saito Sakae 齋藤さかえ

SAITO Sakae 齋藤さかえ