WATANABE Yasuhiro 渡辺保裕

… Alternative Names

渡辺保裕ワタナベヤスヒロ

Watanabe Yasuhiro 渡辺保裕

渡邉保裕ワタナベヤスヒロ

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Researcher Number	20335540
Other IDs
Affiliation (Current)	2025: 鳥取大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 鳥取大学, 医学部, 准教授 2013 – 2018: 鳥取大学, 医学部, 講師 2007: Tottori University, 医学部・附属病院, 助教 2005 – 2006: 鳥取大学, 医学部附属病院, 助手 2003: 鳥取大, 医学部附属病院, 助手 2002: 鳥取大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related / Neurology
Keywords	Principal Investigator 筋萎縮性側索硬化症 / 細胞移植 / 神経栄養因子 / 原発性進行性失語症 / 原発性進行性失語症 / 前頭側頭型認知症 / 神経成長因子 / 神経細胞死 / 筋萎縮性側索症 / 細胞シート … More / 細胞治療 / 再生医療 / 遺伝子治療 / 人口染色体 / 人工染色体 / olfactory ensheathing cell / 定位脳手術 / 間葉系幹細胞 / トランスジェニックマウス / apoptosis / Bcl-2 / 破傷風毒素 Less

Neuropsychological and neuroradiorodical examination in amyotrophic lateral sclerosis (including language evaluation))Principal Investigator
- Principal Investigator
  
  WATANABE Yasuhiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tottori University
Intraventricular pulsatile injection of trophic factors in mice model of ALSPrincipal Investigator
- Principal Investigator
  
  WATANABE Yasuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tottori University
Use of a human artificial chromosome for delivering trophic factorsPrincipal Investigator
- Principal Investigator
  
  Watanabe Yasuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tottori University
家族性筋萎縮性側索硬化症モデルマウスに対する神経幹細胞治療Principal Investigator
- Principal Investigator
  
  渡邉保裕
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Tottori University
破傷風毒素とBc1-2の融合蛋白を用いた運動神経細胞死抑制Principal Investigator
- Principal Investigator
  
  渡邉保裕 (渡辺保裕)
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Tottori University

[Book] 神経症候群（第２版）2014
- Author(s)
  渡辺保裕，中島健二
- Total Pages
  5
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-25461315
[Journal Article] Roles of microglia/macrophage and antibody in cell sheet transplantation in the central nervous system2022
- Author(s)
  Honda Naoto、Watanabe Yasuhiro、Tokuoka Yuta、Hanajima Ritsuko
- Journal Title
  
  Stem Cell Research & Therapy
  
  Volume: 13 Issue: 1 Pages: 470-470
- DOI
  10.1186/s13287-022-03168-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18429, KAKENHI-PROJECT-20K07867
[Journal Article] Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial2022
- Author(s)
  Imamura K、Izumi Y、Nagai M、Nishiyama K、Watanabe Y、Hanajima R、Egawa N、Ayaki T、Oki R、Fujita K、Uozumi R、Morinaga A、Hirohashi T、Fujii Y、Yamamoto T、Tatebe H、Tokuda T、Takahashi N、Morita S、Takahashi R、Inoue H
- Journal Title
  
  eClinicalMedicine
  
  Volume: 53 Pages: 101707-101707
- DOI
  10.1016/j.eclinm.2022.101707
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07883, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-20K07867
[Journal Article] SOD1-interacting proteins: Roles of aggregation cores and protein degradation systems2021
- Author(s)
  Une Mio、Yamakawa Miho、Watanabe Yasuhiro、Uchino Kazuyuki、Honda Naoto、Adachi Mayuka、Nakanishi Mami、Umezawa Akihiro、Kawata Yasushi、Nakashima Kenji、Hanajima Ritsuko
- Journal Title
  
  Neuroscience Research
  
  Volume: 170 Pages: 295-305
- DOI
  10.1016/j.neures.2020.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07867
[Journal Article] Dravet syndrome with parkinsonian symptoms and intact dopaminergic neurons: A case report2021
- Author(s)
  Kanatani M, Adachi T, Sakata R, Nishimura Y, Saito Y, Maegaki Y, Watanabe Y, Hanajima R.
- Journal Title
  
  Brain and development
  
  Volume: 43 Issue: 3 Pages: 486-489
- DOI
  10.1016/j.braindev.2020.10.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07783, KAKENHI-PROJECT-20K07867
[Journal Article] The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) for Japanese ALS and FTD patients2021
- Author(s)
  Watanabe Yasuhiro、Ogino Mieko、Ichikawa Hiroo、Hanajima Ritsuko、Nakashima Kenji
- Journal Title
  
  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  
  Volume: 22 Issue: 1-2 Pages: 66-72
- DOI
  10.1080/21678421.2020.1801751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07867
[Journal Article] Cognitive and behavioral status in Japanese ALS patients: a multicenter study.2020
- Author(s)
  Watanabe Y, Raaphorst J, Izumi Y, Yoshino H, Ito S, Adachi T, Takigawa H, et al.
- Journal Title
  
  Journal of Neurology
  
  Volume: 267 Issue: 5 Pages: 1321-1330
- DOI
  10.1007/s00415-019-09655-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07939, KAKENHI-PROJECT-16K09239, KAKENHI-PROJECT-17K09778, KAKENHI-PROJECT-20K07867
[Journal Article] 筋萎縮性側索硬化症（ALS）[指定難病２]2020
- Author(s)
  渡辺保裕
- Journal Title
  
  指定難病ペディア2019
  
  Volume: 148 Pages: 83-85
- Data Source
  KAKENHI-PROJECT-20K07867
[Journal Article] 増大特集 ALS2019 ALSとFTD2019
- Author(s)
  渡辺保裕
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 71 Issue: 11 Pages: 1227-1235
- DOI
  10.11477/mf.1416201432
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2019-11-01
- Data Source
  KAKENHI-PROJECT-20K07867
[Journal Article] Cowden Syndrome with a Novel <i>PTEN</i> Mutation Presenting with Partial Epilepsy Related to Focal Cortical Dysplasia2018
- Author(s)
  Adachi T, Takigawa H, Nomura T, Watanabe Y, Kowa H
- Journal Title
  
  Intern. Med.
  
  Volume: 57 Issue: 1 Pages: 97-99
- DOI
  10.2169/internalmedicine.9052-17
- NAID
  130006301270
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09239, KAKENHI-PROJECT-16K09719, KAKENHI-PROJECT-16K19312
[Journal Article] Tetanus toxin fragments and Bcl-2 fusion proteins: cytoprotection and retrograde axonal migration.2018
- Author(s)
  Watanabe Y, Matsuba T, Nakanishi M, Une M, Hanajima R, Nakashima K.
- Journal Title
  
  BMC Biotechnol.
  
  Volume: 18 Issue: 1 Pages: 39-39
- DOI
  10.1186/s12896-018-0452-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09719
[Journal Article] 下肢筋力低下で発症しSOD1L126S変異を認めた家族性筋萎縮性側索硬化症の3例2017
- Author(s)
  種田健太，足立正，足立芳樹，渡辺保裕，花島律子
- Journal Title
  
  神経内科
  
  Volume: 87 Pages: 545-549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09719
[Journal Article] Japanese version of the ALS-FTD-Questionnaire (ALS-FTD-Q-J).2016
- Author(s)
  Watanabe Y, et al.
- Journal Title
  
  J Neurol Sci
  
  Volume: 367 Pages: 51-55
- DOI
  10.1016/j.jns.2016.05.036
- Data Source
  KAKENHI-PROJECT-16K09719
[Journal Article] Structural basis of Cu, Zn-superoxide dismutase amyloid fibril formation involves interaction of multiple peptide core regions2016
- Author(s)
  Ida, M. Ando, M. Adachi, M. Tanaka, A. Machida, K. Hongo, K. Mizobata, T. Yamakawa, M. Y. Watanabe, Y. Nakashima, K. Kawata, Y.
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 159 Issue: 2 Pages: 247-260
- DOI
  10.1093/jb/mvv091
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440026, KAKENHI-PROJECT-25440027, KAKENHI-PROJECT-25461315, KAKENHI-PROJECT-16K09719
[Journal Article] Anthocyanin suppresses the toxicity of Abeta deposits through diversion of molecular forms in in vitro and in vivo models of Alzheimer's disease2016
- Author(s)
  Yamakawa, M. Y. Uchino, K. Watanabe, Y. Adachi, T. Nakanishi, M. Ichino, H. Hongo, K. Mizobata, T. Kobayashi, S. Nakashima, K. Kawata, Y.
- Journal Title
  
  Nutritional Neuroscience
  
  Volume: 19 Issue: 1 Pages: 32-42
- DOI
  10.1179/1476830515y.0000000042
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440026, KAKENHI-PROJECT-25440027, KAKENHI-PROJECT-16K09719
[Journal Article] Use of a Human Artificial Chromosome for Delivering Trophic Factors in a Rodent Model of Amyotrophic Lateral Sclerosis.2015
- Author(s)
  Watanabe Y, Kazuki Y, Kazuki K, Ebiki M, Nakanishi M, Nakamura K, Yoshida Yamakawa M, Hosokawa H, Ohbayashi T, Oshimura M, Nakashima K.
- Journal Title
  
  Mol Ther Nucleic Acids.
  
  Volume: 4 Pages: e253-e253
- DOI
  10.1038/mtna.2015.28
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K12141, KAKENHI-PROJECT-25461315, KAKENHI-PROJECT-25540134
[Journal Article] Use of Ramelteon for the Treatment of Secondary REM Sleep Behavior Disorder2013
- Author(s)
  Nomura T, Kawase S, Watanabe Y, Nakashima K.
- Journal Title
  
  Intern. Med.
  
  Volume: 52 Issue: 18 Pages: 2123-2126
- DOI
  10.2169/internalmedicine.52.9179
- NAID
  130003365835
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461315
[Journal Article] Mitochdndrial changes in motor neurons of homozygotes of leucine 126 TT deletion SOD1 transgenic mice.2008
- Author(s)
  Doi K, Watanabe Y, et. al.
- Journal Title
  
  Neuropathology 28
  
  Pages: 269-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17790582
[Journal Article] Gene expression analysis of the murine model of amyotrophic lateral sclerosis: studies of the Leul26delTT mutation in SOD1.2007
- Author(s)
  Fukada Y, Watanabe Y, et. al.
- Journal Title
  
  Brain Res. 1160
  
  Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17790582
[Journal Article] Olfactory ensheathing cell Tranplantation in ALS model mice2006
- Author(s)
  Watanabe Y, et al.
- Journal Title
  
  Amyotrophic lateral sclerosis 7・supple 1
  
  Pages: 119-119
- Data Source
  KAKENHI-PROJECT-17790582
[Journal Article] Mouse motor neuron disease caused by truncated SOD1 with or without C-terminal modification2005
- Author(s)
  Y Watanabe
- Journal Title
  
  Brain Res Mol Brain Res. 135(1-2)
  
  Pages: 12-20
- Data Source
  KAKENHI-PROJECT-17790582
[Patent] 視線運動の評価による神経変性疾患診断補助ツール2020
- Inventor(s)
  渡辺保裕，上原正剛
- Industrial Property Rights Holder
  渡辺保裕，上原正剛
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-086916
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K07867
[Presentation] Clinical trial of bosutinib for amyotrophic lateral sclerosis: Induced pluripotent stem cell-based Drug Repurposing for Amyotrophic Lateral Sclerosis Medicine (iDReAM) study2021
- Author(s)
  Keiko Imamura, Yuishin Izumi, Makiko Nagai, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ritsuko Hanajima, Naohiro Egawa, Takashi Ayaki, Ryosuke Oki, Koji Fujita, Akiko Morinaga, Tomoko Hirohashi, Yosuke Fujii, Naoto Takahashi, Ryuji Uozumi, Satoshi Morita, Ryosuke Takahashi, Haruhisa Inoue
- Organizer
  32nd international symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07867
[Presentation] A phase I dose escalation study of bosutinib for amyotrophic lateral sclerosis: Induced pluripotent stem cell-based drug repurposing for amyotrophic lateral sclerosis medicine (IDREAM) study2021
- Author(s)
  Haruhisa Inoue, Keiko Imamura, Yuishin Izumi, Makiko Nagai, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ritsuko Hanajima, Naohiro Egawa, Takashi Ayaki, Ryosuke Oki, Koji Fujita, Akiko Morinaga, Tomoko Hirohashi, Yosuke Fujii, Satoshi Morita, Ryosuke Takahashi
- Organizer
  the World Congress of Neurology (WCN 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07867
[Presentation] The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) for Japanese ALS and FTD Patients2020
- Author(s)
  7.Yasuhiro Watanabe, Mieko Ogino, Hiroo Ichikawa, Kenji Nakashima, Ritsuko Hanajima
- Organizer
  第61回神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07867
[Presentation] 細胞シート状態で大脳へ移植した間葉系幹細胞の生着に関与する因子の検討．2019
- Author(s)
  本多直人，渡辺保裕，花島　律子，寺嶋智也
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-16K09719
[Presentation] Rretrograde axonal migration and neuroprotection of tetanus toxin fragments and Bcl2 fusion proteins2017
- Author(s)
  Watanabe Y, Matsuba T, Nkanishi M, Une M, Hnajima R
- Organizer
  28th International Symposium on ASL/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09719
[Presentation] Identification of protein-interacting Cu/Zn superoxide dismutase (SOD1): participation of the SOD1 aggregation core and the protein degradation system2017
- Author(s)
  Une M, Yamakawa M, Nakanishi M, Kawata Y, Watanabe Y, Nakashima K, Hanajima R
- Organizer
  28th International Symposium on ASL/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09719
[Presentation] The ability of retrograde axonal migration and neuroprotection of tetanus toxin fragments and Bcl2 fusion proteins2017
- Author(s)
  Watanabe Y, Nakanishi M, Une M, Nakashima K
- Organizer
  23rd World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09719
[Presentation] Efficacy of long-term engraftment of modified MSCs in a mouse model of ALS - use of cell-sheet technology2017
- Author(s)
  Nakanisi M, Une M, Watanabe Y Nakashima K, Hanajima R
- Organizer
  28th International Symposium on ASL/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09719
[Presentation] 細胞移植によるALS治療法開発の可能性2014
- Author(s)
  渡辺保裕
- Organizer
  筋萎縮側索硬化症（ALS）新規治療法開発をめざした病態解明　平成26年度　ワークショップ
- Place of Presentation
  都市センターホテル（東京都千代田区）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-25461315
[Presentation] 人工染色体改変ヒト骨髄間葉系幹細胞を用いたALSモデルマウスに対する細胞移植2013
- Author(s)
  渡辺保裕，安井建一，中野俊也，中島健二
- Organizer
  第31回日本神経治療学会総会
- Place of Presentation
  東京ドームホテル
- Data Source
  KAKENHI-PROJECT-25461315
[Presentation] Chromosomally-modified mesenchymal stem cells secreting GDNF, IGF-1, and HGF attenuate disease progression in an ALS animal model2013
- Author(s)
  Y Watanabe, M Yamakawa, M Ebiki, H Hosokawa, K Yasui, T Nakano, and K Nakashima.
- Organizer
  24th international symposium on ALS/MND
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-25461315
[Presentation] Optimal conditions for transplantation of mesenchymal stem cells in the ALS model
- Author(s)
  M Ebiki, K Nakamura, Y Watanabe, Y Kazuki, M Yoshida-Yamakawa, H Hosokawa, M Oshimura, K Nakashima
- Organizer
  25th International Symposium on ALS/MND
- Place of Presentation
  Brussels, Belgium
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-25461315
[Presentation] 神経栄養因子高発現型間葉系幹細胞のALSモデルマウスへの適正な移植条件の検討
- Author(s)
  恵比木満喬，中村和臣，細川洋行，中西真実，山川三穂，渡辺保裕，中島健二
- Organizer
  第32回日本神経治療学会総会
- Place of Presentation
  東京ドームホテル（東京都文京区）
- Year and Date
  2014-11-20 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25461315

1. 本多直人 (10838486)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 笹岡直人 (80432607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TOKUOKA Yuta

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 江川斉宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 溝端知宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 足立正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 瀧川洋史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 大林徹也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 中村和臣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WATANABE Yasuhiro 渡辺 保裕

渡辺 保裕 ワタナベ ヤスヒロ

Watanabe Yasuhiro 渡辺 保裕

渡邉 保裕 ワタナベ ヤスヒロ

Research Projects

Research Products

Co-Researchers

Neuropsychological and neuroradiorodical examination in amyotrophic lateral sclerosis (including language evaluation))Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intraventricular pulsatile injection of trophic factors in mice model of ALSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Use of a human artificial chromosome for delivering trophic factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

家族性筋萎縮性側索硬化症モデルマウスに対する神経幹細胞治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

破傷風毒素とBc1-2の融合蛋白を用いた運動神経細胞死抑制Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 神経症候群（第２版）2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Roles of microglia/macrophage and antibody in cell sheet transplantation in the central nervous system2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SOD1-interacting proteins: Roles of aggregation cores and protein degradation systems2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dravet syndrome with parkinsonian symptoms and intact dopaminergic neurons: A case report2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) for Japanese ALS and FTD patients2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cognitive and behavioral status in Japanese ALS patients: a multicenter study.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 筋萎縮性側索硬化症（ALS）[指定難病２]2020

Author(s)

Journal Title

Data Source

[Journal Article] 増大特集 ALS2019 ALSとFTD2019

Author(s)

Journal Title

DOI

WATANABE Yasuhiro 渡辺保裕

渡辺保裕ワタナベヤスヒロ

Watanabe Yasuhiro 渡辺保裕

渡邉保裕ワタナベヤスヒロ