Kotake Yaichiro 古武弥一郎

… Alternative Names

Researcher Number	20335649
Other IDs	https://orcid.org/0000-0003-2645-3078
Affiliation (Current)	2019: 広島大学, 医系科学研究科(薬), 教授
Affiliation (based on the past Project Information) *help	2018 – 2019: 広島大学, 医歯薬保健学研究科(薬), 教授 2016 – 2017: 広島大学, 医歯薬保健学研究科(薬), 准教授 2015 – 2016: 広島大学, 医歯薬保健学研究院(薬), 准教授 2014 – 2015: 広島大学, 大学院医歯薬保健学研究院(薬), 准教授 2014: 広島大学, 大学院医歯薬保健学研究院, 准教授 … More
Review Section/Research Field	Principal Investigator Environmental pharmacy / Risk sciences of radiation/Chemicals / Environmental and hygienic pharmacy / Drug development chemistry / Risk sciences of radiation and chemicals / Medium-sized Section 58:Society medicine, nursing, and related fields Except Principal Investigator Environmental pharmacy / Risk sciences of radiation/Chemicals / Environmental and hygienic pharmacy / 医薬分子機能学 … More
Keywords	Principal Investigator 環境化学物質 / グルタミン酸受容体 / 神経毒性 / 有機スズ / グルタミン酸 / 核呼吸因子-1 / パーキンソン病 / 大脳皮質 / 神経細胞死 / ATP … More Except Principal Investigator パーキンソニズム / 神経毒 / パーキンソン病 / 薬物動態 / Parkinson's disease / 毒性 / 化学物質 / 薬物代謝酵素 / 1MeTIQ / サワーソップ / Annonaceae family / テトラヒドロイソキノリン / parkinsonism / tetrahydroisoquinoline / β-チューブリン / ユビキチン化 / チューブリン / parkin / ユビキチン化阻害 / テトラハイドロイソキノリン / Parkin / 神経毒性 / ニューロステロイド / エストラジオール / 海馬 / メチル水銀 / トリブチルスズ / 神経保護作用 / プロゲステロン / トリメチルスズ / ヒト肝細胞移植キメラマウス / リスク評価 / 薬物代謝 / 薬学 / ユビキチンプロテアソーム / アセトアミノフェン / 3次元培養 / オートファジー / サルゾリノール / 代謝変換 / ドーパミン神経 / 1ベンジルTIQ / ミトコンドリア呼吸鎖阻害 / 細胞培養系 / tetrahydroisogunoline / anti-parkinsonian drug / structure-activity relationship / アルカロイド / レティキュリン / ノルレティキュリン / 国際情報交換 / フィリピン:フランス / tetrahvdroisogunoline / SH-SY5Y cells / progressive supranuclear palsy / テトラヒドロイソキノリン類 / P糖タンパク質 / バンレイシ科 / benzylisoguinoline / reticuline / N-methylcoculaurine / LC / MS / French West Indies / P糖蛋白質 / プロドラッグ / P-glycoprotein / neurotxin / prodrug / カリブ諸島 / Annonaceae / neurotoxin / Caribbean islands / 薬毒物 / 代謝 / 心筋細胞 / 神経細胞 / 肝細胞 / スフェロイド / 危険ドラッグ / 動態 / 構造活性相関 / 小胞体ストレス / セロトニントランスポーター / プロテインキナーゼC / 神経変性疾患 / 肝再生 / トランスポーター / 肝臓 / 小腸 Less

Identification of novel ER stress relieving drugs using a high-content microscope and application to therapeutic developmentOngoing
- Principal Investigator
  
  酒井規雄
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Hiroshima University
危険ドラッグの新規化学構造と毒性・動態相関の解明およびヒトへの影響予測Ongoing
- Principal Investigator
  
  太田茂
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58040:Forensics medicine-related
- Research Institution
  Hiroshima University
肝再生における臓器間連携による薬物動態変化と毒性発現を考慮した薬物治療戦略Ongoing
- Principal Investigator
  
  佐能正剛
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hiroshima University
Risk of Parkinson's disease focused on the cause of diabetesPrincipal InvestigatorOngoing
- Principal Investigator
  
  古武弥一郎
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Hiroshima University
Structure-toxicity relationship of designer drug having phenethylamine moietyPrincipal Investigator
- Principal Investigator
  
  KOTAKE YAICHIRO
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Hiroshima University
Development of neuro and cardiac toxicity models considering disposition and interactions of toxic chemicals
- Principal Investigator
  
  Ohta Shigeru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Legal medicine
- Research Institution
  Hiroshima University
Neurotoxicity of organotins via nuclear respiratory factor-1 (NRF-1) inhibitionPrincipal Investigator
- Principal Investigator
  
  古武弥一郎
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hiroshima University
Assessment of toxicity associated with protein degradation of drug-metabolizing enzymes by cehemicals in three-dimensional culture
- Principal Investigator
  
  Ohta Shigeru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Hiroshima University
Cell response of glutamate transporter against rotenonePrincipal Investigator
- Principal Investigator
  
  Kotake Yaichiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Hiroshima University
Investigation and model preparation of tropical area-specific endemic neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  KOTAKE Yaichiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hiroshima University
Can tubulin be a novel target of toxicity of environmental chemicals ?Principal Investigator
- Principal Investigator
  
  KOTAKE Yaichiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Hiroshima University
Organotin-induced GluR2 decrease and its in vivo neuronal effectsPrincipal Investigator
- Principal Investigator
  
  KOTAKE Yaichiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Hiroshima University
Risk assessment of chemicals using chimeric mice with humanized liver
- Principal Investigator
  
  OHTA SHIGERU
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hiroshima University
Protective effect of neurosteroids on developmental brains
- Principal Investigator
  
  YAMAZAKI Takeshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Hiroshima University
Pathogenetic mechanism of sporadic Parkinson's disease based on familial Parkinson's disease
- Principal Investigator
  
  OHTA Shigeru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hiroshima University
Neuronal cell death induced by ATP-decreasing environmental chemicalsPrincipal Investigator
- Principal Investigator
  
  KOTAKE Yaichiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hiroshima University
Development of anti-Parkinson's disease drugs using P-glycoprotein knockout mice heated with endogenous neurotoxin.
- Principal Investigator
  
  OHTA Shigeru
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hiroshima University
Integrated analysis of environmental and genetic factors against Caribbean parkinsonism
- Principal Investigator
  
  OHTA Shigeru
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hiroshima University
環境化学物質のグルタミン酸神経毒性メカニズムによる系統的分類と構造毒性相関Principal Investigator
- Principal Investigator
  
  古武弥一郎
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hiroshima University
Elucidation of the cause of Caribbean parkinsonism and prevention in other area
- Principal Investigator
  
  OHTA Shigeru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY
Development of anti-parkinsonian drug using structure-activity relationship
- Principal Investigator
  
  OHTA Shigeru
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  HIROSHIMA UNIVERSITY
Detection of parkinsonism causing substances in French West Indies
- Principal Investigator
  
  OHTA Shigeru
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  HIROSHIMA UNIVERSIlY

[Book] Gereral and Applied Toxicology 3rd edition
- Author(s)
  Kitamura S., Sugihara K., Nakamura K., Kotake Y., Kashiwagi A., Fujimoto N
- Publisher
  Endocrine disruption in toxic response.(in press)
- Data Source
  KAKENHI-PROJECT-19790106
[Journal Article] Coordinated cytochrome P450 expression in mouse liver and intestine under different dietary conditions during liver regeneration after partial hepatectomy2019
- Author(s)
  Fujino Chieri、Sanoh Seigo、Tateno Chise、Ohta Shigeru、Kotake Yaichiro
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 370 Pages: 133-144
- DOI
  10.1016/j.taap.2019.03.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06750
[Journal Article] Perfluorooctane sulfonate induces neuronal vulnerability by decreasing GluR2 expression2017
- Author(s)
  Ishida K., Tsuyama Y., Sanoh S., Ohta S., Kotake Y.
- Journal Title
  
  Archives of Toxicology
  
  Volume: 未定 Pages: 885-895
- DOI
  10.1007/s00204-016-1731-x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J06534, KAKENHI-PROJECT-16K15147, KAKENHI-PROJECT-15H02826
[Journal Article] Mild MPP(+) exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation.2017
- Author(s)
  Sakamoto S, Miyara M, Sanoh S, Ohta S, Kotake Y
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Pages: 46668-46668
- DOI
  10.1038/srep46668
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K15147
[Journal Article] Low-Concentration Tributyltin Decreases GluR2 Expression via Nuclear Respiratory Factor-1 Inhibition2017
- Author(s)
  Ishida Keishi、Aoki Kaori、Takishita Tomoko、Miyara Masatsugu、Sakamoto Shuichiro、Sanoh Seigo、Kimura Tomoki、Kanda Yasunari、Ohta Shigeru、Kotake Yaichiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 18
- DOI
  10.3390/ijms18081754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02826
[Journal Article] Lead-Induced ERK Activation Is Mediated by GluR2 Non-containing AMPA Receptor in Cortical Neurons2017
- Author(s)
  Ishida K, Kotake Y, Sanoh S, Ohta S.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 40(3) Issue: 3 Pages: 303-309
- DOI
  10.1248/bpb.b16-00784
- NAID
  130005398478
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J06534, KAKENHI-PROJECT-16K15147, KAKENHI-PROJECT-15H02826
[Journal Article] Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation2017
- Author(s)
  Santoh M, Sanoh S, Ohtsuki Y, Ejiri Y, Kotake Y, Ohta S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 486 Pages: 303-309
- DOI
  10.1016/j.bbrc.2017.03.073
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293029, KAKENHI-PROJECT-16K15147
[Journal Article] Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction2016
- Author(s)
  Santoh M, Sanoh S, Takagi M, Ejiri Y, Kotake Y, Ohta S.
- Journal Title
  
  SCIENTIFIC REPORTS
  
  Volume: 6 Pages: 21373-21373
- DOI
  10.1038/srep21373
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293029
[Journal Article] Methoxychlor and fenvalerate induce neuronal death by reducing GluR2 expression2016
- Author(s)
  Umeda K., Kotake Y., Miyara M., Ishida K., Sanoh S., Ohta S.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 41 Issue: 2 Pages: 255-264
- DOI
  10.2131/jts.41.255
- NAID
  130005132655
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J06534, KAKENHI-PROJECT-16K15147
[Journal Article] Mild MPP+exposure impairs autophagic degradation through a novel lysosomal acidity-independent mechanism2016
- Author(s)
  Miyara M, Kotake Y, Tokunaga W, Sanoh S, Ohta S
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 139 Pages: 294-308
- DOI
  10.1111/jnc.13700
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K15147, KAKENHI-PROJECT-15H02826
[Journal Article] Detection of metabolic activation leading to drug-induced phospholipidosis in rat hepatocyte spheroids2016
- Author(s)
  Takagi M, Sanoh S, Santoh M, Ejiri Y, Kotake Y, Ohta S
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 41 Issue: 1 Pages: 155-164
- DOI
  10.2131/jts.41.155
- NAID
  130005119791
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293029
[Journal Article] Tributyltin induces G2/M cell cycle arrest via NAD<sup>+</sup>-dependent isocitrate dehydrogenase in human embryonic carcinoma cells2016
- Author(s)
  Asanagi M, Yamada S, Hirata N, Itagaki H, Kotake Y, Sekino Y, Kanda Y
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 41 Issue: 2 Pages: 207-215
- DOI
  10.2131/jts.41.207
- NAID
  130005132668
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K15147
[Journal Article] Protein extracts from cultured cells contain nonspecific serum albumin2016
- Author(s)
  Miyara M*, Umeda K*, Ishida K, Sanoh S, Kotake Y, Ohta S. *equal contribution
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: Epub ahead of print Pages: 1164-1167
- DOI
  10.1080/09168451.2016.1151338
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J06235, KAKENHI-PROJECT-14J06534, KAKENHI-PROJECT-16K15147
[Journal Article] NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells2014
- Author(s)
  Yamada S, Kotake Y, Demizu Y, Kurihara M, Sekino Y, Kanda Y.
- Journal Title
  
  Sci. Rep.
  
  Volume: 4 Pages: 5952-5952
- DOI
  10.1038/srep05952
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24406004, KAKENHI-PROJECT-26460169
[Journal Article] Detection of a novel neurotoxic metabolite of Parkinson's disease-related neurotoxin, 1-benzyl-1,2,3,4- tetrahydroisoquinoline.2014
- Author(s)
  Kotake Y, Sekiya Y, Okuda K, Ohta S.
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 39 Pages: 749-754
- NAID
  130004690962
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24406004
[Journal Article] Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.2014
- Author(s)
  Contu VR, Kotake Y, Toyama T, Okuda K, Miyara M, Sakamoto S, Samizo S, Sanoh S, Kumagai Y, Ohta S.
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 130 Pages: 826-838
- DOI
  10.1111/jnc.12762
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-24406004, KAKENHI-PROJECT-25220103
[Journal Article] Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death.2013
- Author(s)
  Ishida K, Kotake Y, Miyara M, Aoki K, Sanoh S, Kanda Y, Ohta S.
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 38 Pages: 513-521
- NAID
  10031158917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310047
[Journal Article] Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death2013
- Author(s)
  Ishida K, Kotake Y, Miyara M, Aoki K, Sanoh S, Kanda Y, Ohta S
- Journal Title
  
  J Toxicol Sci
  
  Volume: 38(3) Pages: 513-21
- NAID
  10031158917
- URL
  https://www.jstage.jst.go.jp/article/jts/38/3/38513/article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24651061
[Journal Article] Tributyltin-induced endoplasmic reticulum stress and its Ca(2+)-mediated mechanism.2013
- Author(s)
  Isomura M, Kotake Y, Masuda K, Miyara M, Okuda K, Samizo S, Sanoh S, Hosoi T, Ozawa K, Ohta S
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 272(1) Pages: 137-146
- DOI
  10.1016/j.taap.2013.05.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310047, KAKENHI-PROJECT-24406004, KAKENHI-PROJECT-24651061, KAKENHI-PROJECT-25460101
[Journal Article] AMP-activated protein kinase-mediated glucose transport as a novel target of tributyltin in human embryonic carcinoma cells.2013
- Author(s)
  Yamada S, Kotake Y, Sekino Y, Kanda Y
- Journal Title
  
  Metallomics
  
  Volume: 5(5) Pages: 484-491
- DOI
  10.1039/c3mt20268b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310047, KAKENHI-PROJECT-23590322, KAKENHI-PROJECT-24406004, KAKENHI-PROJECT-24651061
[Journal Article] Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death.2013
- Author(s)
  Ishida K, Kotake Y, Miyara M, Aoki K, Sanoh S, Kanda Y, Ohta S.
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 38 Pages: 513-521
- NAID
  10031158917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24651061
[Journal Article] Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death.2013
- Author(s)
  Ishida K, Kotake Y, Miyara M, Aoki K, Sanoh S, Kanda Y, Ohta S.
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 38 Pages: 513-521
- NAID
  10031158917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24406004
[Journal Article] Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death2013
- Author(s)
  Ishida K, Kotake Y, Miyara M, Aoki K, Sanoh S, Kanda Y, Ohta S
- Journal Title
  
  J Toxicol Sci
  
  Volume: 38(3) Pages: 513-21
- NAID
  10031158917
- URL
  https://www.jstage.jst.go.jp/article/jts/38/3/38_513/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310047
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy2012
- Author(s)
  Klionsky DJ,・・・, Kotake Y,・・・,et al.
- Journal Title
  
  Autophagy
  
  Volume: 8(4) Pages: 445-544
- URL
  https://www.landesbioscience.com/journals/autophagy/article/19496/?nocache=1671244998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310047
[Journal Article] Molecular mechanisms of environmental organotin toxicity in mammals2012
- Author(s)
  Kotake Y
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 35(11) Pages: 1876-80
- NAID
  130001872281
- URL
  https://www.jstage.jst.go.jp/article/bpb/35/11/35_b212017/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310047
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy2012
- Author(s)
  Klionsky DJ,・・・, Kotake Y,・・・, et al
- Journal Title
  
  Autophagy
  
  Volume: 8(4) Pages: 445-544
- URL
  https://www.landesbioscience.com/journals/autophagy/article/19496/?nocache=1671244998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24651061
[Journal Article] Prediction of In Vivo Hepatic Clearance and Half-life of Drug Candidates in Human using Chimeric Mice with Humanized Liver.2012
- Author(s)
  Sanoh S., Horiguchi A., Sugihara K., Kotake Y., Tayama Y., Uramaru N., Ohshita H., Tateno C., Horie T., Kitamura S., Ohta S
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 40(2) Pages: 2267-2272
- DOI
  10.1124/dmd.111.040923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510071, KAKENHI-PROJECT-22790109, KAKENHI-PROJECT-23310047, KAKENHI-PROJECT-23390030, KAKENHI-PROJECT-23659053
[Journal Article] Molecular mechanisms of environmental organotin toxicity in mammals2012
- Author(s)
  Kotake
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 35 Pages: 1876-1880
- NAID
  130001872281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310047
[Journal Article] Predictability of metabolism of Ibuprofen and naproxen using chimeric mice with human hepatocytes.2012
- Author(s)
  Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Uramaru N, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 40(12) Pages: 2267-2272
- DOI
  10.1124/dmd.112.047555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310047, KAKENHI-PROJECT-23390030, KAKENHI-PROJECT-23659053, KAKENHI-PROJECT-24651061, KAKENHI-PROJECT-24790111, KAKENHI-PROJECT-24790126
[Journal Article] Molecular mechanisms of environmental organotin toxicity in mammals2012
- Author(s)
  Kotake Y
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 35(11) Pages: 1876-80
- NAID
  130001872281
- URL
  https://www.jstage.jst.go.jp/article/bpb/35/11/35_b212017/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24651061
[Journal Article] Proteindi sulfide isomerase knockdown-induced cell death is cell-line-dependent and involves apoptosis in MCF-7 cells.2011
- Author(s)
  Hashida T, Kotake Y, Ohta S.
- Journal Title
  
  J.Toxicol.Sci. 36
  
  Pages: 1-7
- NAID
  10027420192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390040
[Journal Article] 1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination.2010
- Author(s)
  Kohta R, Kotake Y, Hosoya T, Hiramatsu T, Otsubo Y, Koyama H, Hirokane Y, Yokoyama Y, Ikeshoji H, Oofusa K, Suzuki M, Ohta S.
- Journal Title
  
  J.Neurochem. 114
  
  Pages: 1291-1301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390040
[Journal Article] Involvement of autophagy via mammalian target of rapamycin (mTOR) inhibition in tributyltin-induced neuronal cell death.2010
- Author(s)
  Nakatsu Y, Kotake Y, Takai N, Ohta S.
- Journal Title
  
  J.Toxicol.Sci. 35
  
  Pages: 245-251
- NAID
  10026193491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390040
[Journal Article] Modulation of connexin 43 in rotenone-induced model of Parkinson's disease2009
- Author(s)
  Kawasaki A., Hayashi T., Nakachi K., Trosko J. E., Sugihara K., Kotake Y., Ohta S
- Journal Title
  
  Neuroscience 160
  
  Pages: 61-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790106
[Journal Article] Modulation of connexin 43 in rotenone-induced model of Parkinson's disease.2009
- Author(s)
  Kawasaki A, Hayashi T, Nakachi K, Trosko JE, Sugihara K, Kotake Y, Ohta S.
- Journal Title
  
  Neuroscience 160
  
  Pages: 61-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390040
[Journal Article] Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate.2009
- Author(s)
  Nakatsu Y, Kotake Y, Takishita T, Ohta S.
- Journal Title
  
  Toxicol.Appl.Pharmacol. 240
  
  Pages: 292-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390040
[Journal Article] Activation of AMP-activated protein kinase by tributyltin induces neuronal cell death2008
- Author(s)
  Yusuke, Nakatsu, Yaichiro, Kotake, Atsuko, Hino, Shigeru, Ohta
- Journal Title
  
  Toxicol. Appl. Pharmacol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390037
[Journal Article] Activation of AMP-activated protein kinase by tributyltin induces neuronal cell death.2008
- Author(s)
  Nakatsu Y, Kotake Y, Hino A, Ohta S.
- Journal Title
  
  Toxicol.Appl.Pharmacol. 230
  
  Pages: 358-363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390040
[Journal Article] Activation of AMP-activated protein kinase by tributyltin induces neuronal cell death.2008
- Author(s)
  Nakatsu Y., Kotake Y., Hino A.,Ohta S
- Journal Title
  
  Toxicol.Appl.Pharmacol 230
  
  Pages: 358-363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790106
[Journal Article] Cytotoxicity of 17 tetrahydroisoquinoline derivatives in SH-SY5Y human neuroblastoma cells is related to mitochondrial NADH-ubiquinone oxidoreductase inhibition.2007
- Author(s)
  Kotake Y. et al.
- Journal Title
  
  Neurotoxicology 28・1
  
  Pages: 27-32
- Data Source
  KAKENHI-PROJECT-17790099
[Journal Article] Cytotoxicity of 17 tetrahydroisoquinoline derivatives in SH-SY5Y human neuroblastoma cells is related to mitochondrial NADH-ubiquinone oxidore ductase inhibition.2007
- Author(s)
  Y. Kotake, et. al.
- Journal Title
  
  Neurotoxicology 28
  
  Pages: 27-32
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406004
[Journal Article] Concentration dependence of the mechanisms of tributyltin-induced apoptosis2007
- Author(s)
  Yusuke, Nakatsu, Yaichiro, Kotake, Shigeru, Ohta
- Journal Title
  
  Toxicol. Sci 97
  
  Pages: 438-447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390037
[Journal Article] Neurotoxicity induced by environmental low-molecular-weight substances2007
- Author(s)
  Yaichiro, Kotake, et. al.
- Journal Title
  
  J. Health Sci 53
  
  Pages: 639-643
- NAID
  110006545929
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18406004
[Journal Article] Cytotoxicity of 17 tetrahydroisoquinoline derivatives in SH-SY5Y human neuroblastoma cells is related to mitochondrial NADH-ubiquinone oxidoreductase inhibition2007
- Author(s)
  Yaichiro, Kotake, et. al.
- Journal Title
  
  Neurotoxicol 28
  
  Pages: 27-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18406004
[Journal Article] Neurotoxicity induced by environmental low-molecular-weight substances.(review)2007
- Author(s)
  Kotake Y
- Journal Title
  
  J. Health Sci 53
  
  Pages: 639-643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790106
[Journal Article] Cytotoxicity of 17 tetrahydroisoquinoline derivatives in SH-SY5Y human neuroblastoma cells is related to mitochondrial NADH-ubiquinone oxidore ductase inhibition.2007
- Author(s)
  Y. Kotake, et. al.
- Journal Title
  
  Neurotoxicology 28
  
  Pages: 27-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390037
[Journal Article] Cytotoxicity of 17 tetrahydroisoquinoline derivatives in SH-SY5Y human neuroblastoma cells is related to mitochondrial NADH-ubiquinone oxidoreductase inhibition2007
- Author(s)
  Yaichiro, Kotake, Yoko, Sekiya, Katsuhiro, Okuda, Shigeru, Ohta
- Journal Title
  
  Neurotoxicology 28
  
  Pages: 27-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390037
[Journal Article] Concentration dependence of the mechanisms of tributyltin-indeced apoptosis. Toxicol2007
- Author(s)
  Nakatsu Y., Kotake Y., Ohta S
- Journal Title
  
  Toxicol. Sci 97
  
  Pages: 438-447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790106
[Journal Article] Cytotoxicity of 17 tetrahydroisoquinoline derivatives in SH-SY5Y human neuroblastoma cells is related to mitochondrial NADH-ubiquinone oxidore ductase inhibition.2007
- Author(s)
  Y. Kotake, et. al.
- Journal Title
  
  Neurotoxicology 28
  
  Pages: 27-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790106
[Journal Article] Neurotoxicity induced by environmental low-molecular-weight substances.2007
- Author(s)
  Y. Kotake
- Journal Title
  
  J. Health Sci. 53
  
  Pages: 639-643
- NAID
  110006545929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790106
[Journal Article] Cytotoxicity of 17 tetrahydroisoquinolinederivatives in SH-SY5Y human neuroblastomacells is related to mitochondrialNADH-ubiquinone oxidoreductase inhibition2007
- Author(s)
  Kotake Y.,Sekiya Y.,Okuda K.,Ohta S
- Journal Title
  
  Neurotoxicology 28
  
  Pages: 27-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790106
[Journal Article] Cytotoxicity of 17 tetrahydroisoquinoline derivatives in SH-SY5Y human neuroblastoma cells is related to mitochondria)NADH-ubiquinone oxidoreductase inhibition.2007
- Author(s)
  Y. Kotake, et. al.
- Journal Title
  
  Neurotoxicology 28
  
  Pages: 27-32
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390037
[Journal Article] Ohta, "Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons."2006
- Author(s)
  Yusuke, Nakatsu, Yaichiro, Kotake, Kazuya, Komasaka, Hiroko, Hakozaki, Ryota, Taguchi, Toshiaki, Kume, Akinori, Akaike, Shigeru
- Journal Title
  
  Toxicol. Sci 89
  
  Pages: 235-242
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390037
[Journal Article] Tributyltin-induced cell death is meadiated by calpain in PC12 cells2006
- Author(s)
  Yusuke, Nakatsu, Yaihchiro, Kotake, Shigeru, Ohta
- Journal Title
  
  Neurotoxicology 27
  
  Pages: 587-593
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390037
[Journal Article] Parkinsonism-preventing activity of 1-methyl-1,2,3,4-tetrahydroisoquinoline derivatives in C57BL mouse in vivo2006
- Author(s)
  Katsuhiro, Okuda, Yaichiro, Kotake, Shigeru, Ohta
- Journal Title
  
  Biol. Pharm. Bull 29
  
  Pages: 1401-1403
- NAID
  110005602310
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390037
[Journal Article] Neuroprotective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins.2005
- Author(s)
  Kotake Y. et al.
- Journal Title
  
  Brain Res. 1033
  
  Pages: 143-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406004
[Journal Article] Neuroprotective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins2005
- Author(s)
  Y.Kotake et al.
- Journal Title
  
  Brain Res. 1033
  
  Pages: 143-150
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16406004
[Journal Article] Neuroprotective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins.2005
- Author(s)
  Y.Kotake et al.
- Journal Title
  
  Brain Res. 1033
  
  Pages: 143-150
- Data Source
  KAKENHI-PROJECT-16406004
[Journal Article] Detection and determination of reticuline and N-methylcoculaurine in the Annonaceae family using liquid chromatography-tandem mass spectrometry.2004
- Author(s)
  Kotake Y. et al.
- Journal Title
  
  Chromatography B. 806
  
  Pages: 75-78
- NAID
  10016551931
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406004
[Journal Article] Detection and determination of reticuline and N-methylcoculaurine in the Annonaceae family using liquid chromatography-tandem mass spectrometry.2004
- Author(s)
  Y.Kotake, et al.
- Journal Title
  
  J.Chromatogr.B 806
  
  Pages: 75-78
- NAID
  10016551931
- Data Source
  KAKENHI-PROJECT-16406004
[Presentation] 神経・肝・心筋細胞の3次元培養系の構築とジフェンヒドラミンの毒性評価2019
- Author(s)
  今子千鶴，佐能正剛，藤野智恵里，大月佑也，采洋太朗，髙木優志，山頭征岳，宮良政嗣，江尻洋子，奥田勝博，藤本成明，河合秀彦，太田茂，古武弥一郎
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18H03066
[Presentation] 合成したフェネチルアミン誘導体の薬理評価および構造毒性相関に関する研究2018
- Author(s)
  須山翔太，佐能正剛，梅原祥太，奥田勝博，太田茂、古武弥一郎
- Organizer
  日本法中毒学会第37年会
- Data Source
  KAKENHI-PROJECT-18H03066
[Presentation] 核呼吸因子-1発現減少による網羅的な遺伝子発現変動2018
- Author(s)
  齊木崇史，石田慶士，太田茂，古武弥一郎
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H02826
[Presentation] Characterization of varidations in CYP expression during liver regeneration after partial hepatectomy in mice: possible contribution of endogeneous molecules2018
- Author(s)
  Fujino Chieri, Sanoh Seigo,Tateno Chise, Ohta Shigeru, Kotake Yaichiro,
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06750
[Presentation] 化学合成した危険ドラッグの薬理評価と毒性化学構造同定2018
- Author(s)
  須山翔太，佐能正剛，梅原祥太，奥田勝博，太田茂、古武弥一郎
- Organizer
  「広島神経医科学研究会」第2回学生・若手研究者ポスター発表会
- Data Source
  KAKENHI-PROJECT-18H03066
[Presentation] 肝細胞の三次元培養系およびヒト肝細胞移植キメラマウスを用いたカチノン誘導体の共通代謝物の探索2017
- Author(s)
  渡部祥子，佐能正剛，梅原祥太，山頭征岳，江尻洋子，石田雄二，加国雅和，立野知世，古武弥一郎，太田茂
- Organizer
  日本薬学会第137回年会
- Place of Presentation
  仙台国際センター・東北大学川内地区
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26293029
[Presentation] 肝細胞の三次元培養系およびヒト肝細胞移植キメラマウスを用いたカチノン誘導体の共通代謝物の探索2017
- Author(s)
  渡部祥子佐能正剛, 梅原祥太, 山頭征岳, 江尻洋子, 石田雄二, 加国雅和, 立野知世, 古武弥一郎, 太田茂
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K15147
[Presentation] フェネチルアミン誘導体およびカチノン誘導体のin vitro/in vivo 薬物動態評価2016
- Author(s)
  佐能正剛，渡部祥子，須山翔太，梅原祥太，奥田勝博，石田雄二，加国雅和，立野知世，古武弥一郎，太田茂
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-16K15147
[Presentation] 毒性評価系構築を目指した3次元神経細胞培養系の検討2016
- Author(s)
  采洋太朗，古武弥一郎，江尻洋子，佐能正剛，太田茂
- Organizer
  フォーラム2016衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学薬学部
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-16K15404
[Presentation] カチノン誘導体における肝細胞三次元培養系を用いた共通代謝物の探索2016
- Author(s)
  渡部祥子，佐能正剛，須山翔太，梅原祥太，山頭征岳，江尻洋子，古武弥一郎，太田茂
- Organizer
  フォーラム2016衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学薬学部
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-26293029
[Presentation] 毒性評価系構築を目指した3次元神経細胞培養系の検討2016
- Author(s)
  采洋太朗，古武弥一郎，江尻洋子，佐能正剛，太田茂
- Organizer
  フォーラム2016衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学薬学部
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-26293029
[Presentation] ロテノン曝露により放出された因子が大脳皮質神経細胞に与える影響2016
- Author(s)
  ○菅田和子, 古武弥一郎, 足立暁, 太田茂
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26670063
[Presentation] フェネチルアミン系危険ドラッグのトキシコフォア同定を目指した構造毒性相関研究2016
- Author(s)
  古武弥一郎，梅原祥太，須山翔太，渡部祥子，奥田勝博，佐能正剛，太田茂
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-16K15147
[Presentation] フェネチルアミン誘導体およびカチノン誘導体のin vitro/in vivo薬物動態評価2016
- Author(s)
  佐能正剛，渡部祥子，須山翔太，梅原祥太，奥田勝博，石田雄二，加国雅和，立野知世，古武弥一郎，太田茂
- Organizer
  フォーラム2016衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学薬学部
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-26293029
[Presentation] カチノン誘導体における肝細胞三次元培養系を用いた共通代謝物の探索2016
- Author(s)
  渡部祥子，佐能正剛，須山翔太，梅原祥太，山頭征岳，江尻洋子，古武弥一郎，太田茂
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-16K15147
[Presentation] Acetaminophen induces accumulation of functional rat CYP3A by altering gp78 localization.2016
- Author(s)
  Santoh M, Sanoh S, Takagi M, Ejiri Y, Kotake Y, Ohta S
- Organizer
  The 11th International ISSX Meeting
- Place of Presentation
  BEXCO (Busan, Korea)
- Year and Date
  2016-06-12
- Data Source
  KAKENHI-PROJECT-26293029
[Presentation] ラット肝細胞3次元培養系を用いたカチノン誘導体の還元代謝活性2016
- Author(s)
  佐能正剛、渡部祥子、梅原祥太、山頭征岳、江尻洋子、古武弥一郎、太田茂
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  ウィンクあいち
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-26293029
[Presentation] 有機スズ神経毒性に関与する核呼吸因子-1 (NRF-1) 阻害機構の解明2015
- Author(s)
  石田慶士、古武弥一郎、青木香織、瀧下智子、木村朋紀、諫田泰成、太田　茂
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  金沢市
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-15H02826
[Presentation] アセトアミノフェンが誘発するユビキチンプロテアソーム系阻害を介したラットCYP3A1の蓄積2015
- Author(s)
  山頭征岳, 佐能正剛，髙木優志，江尻洋子，古武弥一郎，太田茂
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26293029
[Presentation] 低濃度トリブチルスズによるニューロン脆弱化機構の解明2015
- Author(s)
  石田慶士、古武弥一郎、青木香織、瀧下智子、木村朋紀、諫田泰成、太田　茂
- Organizer
  メタルバイオサイエンス研究会2015
- Place of Presentation
  名古屋市
- Year and Date
  2015-08-27
- Data Source
  KAKENHI-PROJECT-15H02826
[Presentation] 低濃度MPP+によるオートファジー阻害を介した神経毒性メカニズムの解明2014
- Author(s)
  宮良政嗣, 古武弥一郎, 太田茂
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] 低濃度MPP+によるオートファジー阻害を介した神経毒性メカニズムの解明2014
- Author(s)
  宮良政嗣、古武弥一郎、太田　茂
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24406004
[Presentation] 低濃度MPP+によるオートファジー阻害を介した神経毒性メカニズムの解明2014
- Author(s)
  宮良政嗣、古武弥一郎、太田茂
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24651061
[Presentation] Low concentration of Parkinson's disease-related neurotoxin MPP+ inhibits autophagy2013
- Author(s)
  Miyara M, Kotake Y, Ohta S
- Organizer
  The 13th International Congress of Toxicology
- Place of Presentation
  ソウル(韓国)
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] Low concentration of Parkinson’s disease-related neurotoxin MPP+ inhibits autophagy.2013
- Author(s)
  Miyara M, Kotake Y, Ohta S.
- Organizer
  The 13th International Congress of Toxicology
- Place of Presentation
  ソウル、韓国
- Data Source
  KAKENHI-PROJECT-24406004
[Presentation] パーキンソン病関連神経毒MPP+低濃度曝露によるオートファジー阻害2013
- Author(s)
  宮良政嗣、古武弥一郎、太田　茂
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24406004
[Presentation] パーキンソン病関連神経毒MPP+低濃度曝露によるオートファジー阻害2013
- Author(s)
  宮良政嗣, 古武弥一郎, 太田茂
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] In vitro long-term exposure to perfluorooctane sulfonate (PFOS) leads to decrease in GluR2 protein.2013
- Author(s)
  Tsuyama Y, ○Sugiyama C, Sanoh S, Kotake Y, Ohta S.
- Organizer
  The 13th International Congress of Toxicology
- Place of Presentation
  ソウル、韓国
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] Tributyltin-induced endoplasmic reticulum stress and its mechanism.2013
- Author(s)
  Kotake Y, Isomura M, Masuda K, Miyara M, Okuda K, Samizo S, Sanoh S, Hosoi T, Ozawa K, Ohta S.
- Organizer
  49th Congress of the European Scieties of Toxicology (EUROTOX 2013)
- Place of Presentation
  インターラーケン、スイス
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] 有機スズ投与動物の脳内におけるBDNF発現減少とうつ病様症状の関連2013
- Author(s)
  神野麻美、古武弥一郎、田中早紀、奥田勝博、阿南弥寿美、小椋康光、太田　茂
- Organizer
  フォーラム2013 衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] 神経脆弱化の指標となるGluR2発現簡便評価系の開発2013
- Author(s)
  杉山千尋、古武弥一郎、津山由美、奥田勝博、太田　茂
- Organizer
  フォーラム2013 衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] Low concentration of Parkinson's disease-related neurotoxin MPP+ inhibits autophagy2013
- Author(s)
  Miyara M, Kotake Y, Ohta S
- Organizer
  The 13th International Congress of Toxicology
- Place of Presentation
  ソウル(韓国)
- Data Source
  KAKENHI-PROJECT-24651061
[Presentation] 有機スズによるグルタミン酸受容体発現減少を介した神経影響2013
- Author(s)
  古武弥一郎
- Organizer
  メタルバイオサイエンス 2013
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] グルタミン酸受容体が関与する鉛の神経毒性メカニズム解明2013
- Author(s)
  石田慶士、古武弥一郎、宮良政嗣、青木香織、佐能正剛、諫田泰成、太田　茂
- Organizer
  フォーラム2013 衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] パーキンソン病関連神経毒MPP+低濃度曝露によるオートファジー阻害2013
- Author(s)
  宮良政嗣、古武弥一郎、太田茂
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24651061
[Presentation] 有機スズによるグルタミン酸受容体発現減少を介した神経影響2013
- Author(s)
  古武弥一郎
- Organizer
  メタルバイオサイエンス2013
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24651061
[Presentation] Low concentration of Parkinson’s disease-related neurotoxin MPP+ inhibits autophagy.2013
- Author(s)
  Miyara M, Kotake Y, Ohta S.
- Organizer
  The 13th International Congress of Toxicology
- Place of Presentation
  ソウル、韓国
- Data Source
  KAKENHI-PROJECT-24651061
[Presentation] パーキンソン病関連化学物質による神経毒性メカニズム2012
- Author(s)
  古武弥一郎, 幸田龍紀, 宮良政嗣, 太田茂
- Organizer
  フォーラム 2012 衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] パーキンソン病関連化学物質による神経毒性メカニズム2012
- Author(s)
  古武弥一郎ら
- Organizer
  フォーラム2012 衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] パーキンソン病関連化学物質による神経毒性メカニズムフォーラム2012
- Author(s)
  古武弥一郎、幸田龍紀、宮良政嗣、太田茂
- Organizer
  2012衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24651061
[Presentation] パーキンソン病関連神経毒性物質によるチューブリンのユビキチン化阻害とオートファジー2012
- Author(s)
  古武弥一郎
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] 有機スズ神経毒性のカギを握る核呼吸因子-1発現減少2012
- Author(s)
  古武弥一郎ら
- Organizer
  第3回メタロミクス研究フォーラム
- Place of Presentation
  町田
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] パーキンソン病関連化学物質による神経毒性メカニズム2012
- Author(s)
  古武弥一郎, ら
- Organizer
  フォーラム2012 衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋(招待講演)
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-24406004
[Presentation] パーキンソン病関連神経毒性物質によるチューブリンのユビキチン化阻害とオートファジー2012
- Author(s)
  古武　弥一郎
- Organizer
  第39回日本毒性学会学術年会（招待講演）
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-24651061
[Presentation] パーキンソン病関連神経毒性物質によるチューブリンのユビキチン化阻害とオートファジー2012
- Author(s)
  古武弥一郎
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台(招待講演)
- Year and Date
  2012-07-19
- Data Source
  KAKENHI-PROJECT-24406004
[Presentation] パーキンソン病関連神経毒性物質によるチューブリンのユビキチン化阻害とオートファジー2012
- Author(s)
  古武弥一郎
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24651061
[Presentation] パーキンソン病関連化学物質による神経毒性メカニズム2012
- Author(s)
  古武　弥一郎
- Organizer
  フォーラム2012 衛生薬学・環境トキシコロジー（招待講演）
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-24651061
[Presentation] Disturbance of glutamate receptor expression induced by tributyltin : inplication for brain disease2011
- Author(s)
  Yaichiro Kotake
- Organizer
  5th International Conference of Metals and Genetics
- Place of Presentation
  Kobe(招待講演)
- Year and Date
  2011-09-06
- Data Source
  KAKENHI-PROJECT-23310047
[Presentation] カテコール骨格を有するパーキンソン病関連神経毒がユビキチンE3リガーゼparkinに与える影響2010
- Author(s)
  佐溝茂良、古武弥一郎、廣兼裕司、幸田龍紀、太田茂
- Organizer
  フォーラム2010衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-20390040
[Presentation] パーキンソン病関連神経毒はParkinに影響を与え、小胞体ストレスを誘発する2010
- Author(s)
  佐溝茂良、古武弥一郎、横山雄一、細井徹、小澤光一郎、太田茂
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20390040
[Presentation] パーキンソン病関連神経毒MPP+によるparkin活性阻害と基質タンパク質tubulinの蓄積2010
- Author(s)
  廣兼裕司、古武弥一郎、幸田龍紀、太田茂
- Organizer
  第49回日本薬学会中国四国支部学術大会
- Place of Presentation
  米子
- Year and Date
  2010-11-06
- Data Source
  KAKENHI-PROJECT-20390040
[Presentation] 家族性パーキンソン病原因タンパクParkinに対する1BnTIQの影響2010
- Author(s)
  廣兼裕司、幸田龍紀、古武弥一郎、太田茂
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20390040
[Presentation] パーキンソン病関連伸経毒によるtubuhn結合タンパク質α-synucleinのオリゴマー化2009
- Author(s)
  山脇裕一郎、幸田龍紀、古武弥一郎、太田茂
- Organizer
  フォーラム2009衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-20390040
[Presentation] パーキンソン病関連脳内在性アミンTIQ誘導体の小胞体ストレス誘発作用2009
- Author(s)
  佐溝茂良、古武弥一郎、横山雄一、細井徹、小澤光一郎、太田茂
- Organizer
  フォーラム2009衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-20390040
[Presentation] α-synucleinオリゴマー化に対するパーキンソン病関連神経毒の影響2009
- Author(s)
  山脇裕一郎、幸田龍紀、古武弥一郎、太田茂
- Organizer
  第48回日本薬学会中国四国支部会学術大会
- Place of Presentation
  徳島
- Year and Date
  2009-11-08
- Data Source
  KAKENHI-PROJECT-20390040
[Presentation] パーキンソン病関連神経毒によるParkinタンパク質の不溶化および不活性化2009
- Author(s)
  廣兼裕司、幸田龍紀、古武弥一郎、太田茂
- Organizer
  フォーラム2009衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-20390040
[Presentation] 環境化学物質のタンパク結合を介した作用とパーキンソン病2008
- Author(s)
  古武弥一郎、太田茂
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18406004
[Presentation] 環境化学物質のタンパク結合を介した作用とパーキンソン病2008
- Author(s)
  古武弥一郎他
- Organizer
  日本薬学会第128年会シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2008-03-25
- Data Source
  KAKENHI-PROJECT-19790106
[Presentation] 環境化学物質のタンパク結合を介した作用とパーキンソン病2008
- Author(s)
  古武弥一郎、幸田龍紀、太田茂
- Organizer
  日本薬学会第128年会シンポジウム若手が切り開くMolecular Toxicology3〜化学物質の脳神経毒性とその作用メカニズム〜
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19790106
[Presentation] 環境化学物質のタンパク結合を介した作用とパーキンソン病2008
- Author(s)
  古武弥一郎、太田茂
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390037
[Presentation] 環境汚染化学物質トリブチルスズによるAMP-activated protein kinase を介した神経細胞死2007
- Author(s)
  古武弥一郎他
- Organizer
  第34回日本トキシコロジー学会学術集会
- Place of Presentation
  東京
- Year and Date
  2007-06-27
- Data Source
  KAKENHI-PROJECT-19790106
[Presentation] パーキンソン病関連神経毒1BnTIQはtubulinに結合する2007
- Author(s)
  幸田龍紀、古武弥一郎、泉俊輔、杉原数美、細谷孝充、平松俊行、大坪裕子、古山浩子、鈴木正昭、太田茂
- Organizer
  第30回日本神経科学学会大会・第50回日本神経化学会大会・第17回日本神経回路学会大会合同大
- Place of Presentation
  横浜
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-19790106
[Presentation] パーキンソン病発症物質候補テトラハイドロイソキノリン誘導体のチューブリン結合を介した作用2007
- Author(s)
  古武弥一郎
- Organizer
  北陸大学学術フロンティア推進事業・サテライトミーティング~内因性および外因性因子の毒性発現にかかわる分子標的と生体応答を担うシステム~
- Place of Presentation
  岐阜
- Year and Date
  2007-07-28
- Data Source
  KAKENHI-PROJECT-19790106
[Presentation] パーキンソン病誘発物質はAstrocyteにおいてギャップ結合による細胞間伝達を促進させる2007
- Author(s)
  河嵜麻実、林奉権、中地啓、古武弥一郎、太田茂
- Organizer
  第30回日本神経科学学会大会・第50回日本神経化学会大会・第17回日本神経回路学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-19790106
[Presentation] Parkinsonism-causing toxins enhance gap junction in astrocytes2007
- Author(s)
  Asami, Kawasaki, Tomonori, Hayashi, Kei, Nakachi, Yaichiro, Kotake, Shigeru, Ohta
- Organizer
  Neuro2007
- Place of Presentation
  Yokohama
- Year and Date
  2007-09-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390037
[Presentation] A Parkinson's disease-related neurotoxin binds to tubulin.2007
- Author(s)
  Ryuki, Kohta, Yaichiro, Kotake, Shunsuke, Izumi, Kazumi, Sugihara, Takamitsu, Hosoya, Toshiyuki, Hiramatsu, Yuko, Ohtsubo, Hiroko, Koyama, Masaaki, Suzuki, Shigeru, Ohta
- Organizer
  Neuro 2007
- Place of Presentation
  Yokohama
- Year and Date
  2007-09-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390037
[Presentation] Parkinsonism-causing toxins enhance gap junction in astrocytes2007
- Author(s)
  Asami, Kawasaki, Tomonori, Hayashi, Kei, Nakachi, Kotake, Yaichiro, Shigeru, Ohta
- Organizer
  Neuro2007
- Place of Presentation
  Yokohama
- Year and Date
  2007-09-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18406004
[Presentation] Mechanism of tributyltin-induced cell death in cultured rat cortical neurons2007
- Author(s)
  Y. Kotake, et. al.
- Organizer
  11th International Congress of Toxicology
- Place of Presentation
  モントリオール
- Data Source
  KAKENHI-PROJECT-19790106
[Presentation] 環境汚染化学物質トリブチルスズによるAMP-activated protein kinaseを介した神経細胞死2007
- Author(s)
  古武弥一郎、中津祐介、太田茂
- Organizer
  第34回日本トキシコロジー学会学術年会
- Place of Presentation
  東京
- Year and Date
  2007-06-28
- Data Source
  KAKENHI-PROJECT-19790106
[Presentation] A Parkinson's disease-related neurotoxin binds to tubulin2007
- Author(s)
  Ryuki, Kohta, Yaichiro, Kotake, Shunsuke, Izumi, Kazumi, Sugihara, Takamitsu, Hosoya, Toshiyuki, Hiramatsu, Yuko, Ohtsubo, Hiroko, Koyama, Masaaki, Suzuki, Shigeru, Ohta
- Organizer
  Neuro2007
- Place of Presentation
  Yokohama
- Year and Date
  2007-09-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18406004
[Presentation] パーキンソン病関連神経毒テトラハイドロイソキノリン誘導体によるチューブリンを介した作用2007
- Author(s)
  古武弥一郎
- Organizer
  北陸大学学術フロンティアサテライトシンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-19790106
[Presentation] トリブチルスズによる神経細胞死メカニズム2007
- Author(s)
  古武弥一郎
- Organizer
  第26回チョークトーク生体と金属に関する研究会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-19790106
[Presentation] Neuroprotective mechanism of 1MeTIQ and its derivatives against glutamate-induced neurotoxicity2006
- Author(s)
  Toshiyuki, Ohsawa, Yaichiro, Kotake, Yusuke, Nakatsu, Katsuhiro, Okuda, Shigeru, Ohta
- Organizer
  49th Japanese Society for Neurochemistry
- Place of Presentation
  Nagoya
- Year and Date
  2006-09-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18406004
[Presentation] AMP-activated protein kinase is involved in tributyltin neurotoxicity in cultured cortical neurons.2006
- Author(s)
  Yusuke, Nakatsu, Yaichiro, Kotake, Shigeru, Ohta
- Organizer
  49th Japanese Society for Neurochemistry
- Place of Presentation
  Nagoya
- Year and Date
  2006-09-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390037
[Presentation] AMP-activated protein kinase is involved in tributyltin neurotoxicity in cultured cortical neurons2006
- Author(s)
  Yusuke, Nakatsu, Yaichiro, Kotake, Shigeru, Ohta
- Organizer
  49th Japanese Society for Neurochemistry
- Place of Presentation
  Nagoya
- Year and Date
  2006-09-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18406004
[Presentation] Neuroprotective mechanism of 1MeTIQ and its derivatives against glutamate-induced neurotoxicity2006
- Author(s)
  Toshiyuki, Ohsawa, Yaichiro, Kotake, Yusuke, Nakatsu, Katsuhiro, Okuda, Shigeru, Ohta
- Organizer
  49th Japanese Society for Neurochemistry
- Place of Presentation
  Nagoya
- Year and Date
  2006-09-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390037
[Presentation] ミトコンドリア呼吸鎖阻害剤によるEAAT3発現上昇とそのメカニズム解明
- Author(s)
  足立　暁、古武弥一郎、山本智美、菅田和子、太田　茂
- Organizer
  フォーラム2014　衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-26670063
[Presentation] 低濃度パーキンソン病関連化学物質によるリソソーム機能低下とオートファジー阻害
- Author(s)
  宮良政嗣、古武弥一郎、徳永　航、太田　茂
- Organizer
  フォーラム2014 衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24406004

1. OHTA Shigeru (60160503)

# of Collaborated Projects: 15 results

# of Collaborated Products: 80 results
2. SUGIHARA Kazumi (20271067)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
3. SANOH Seigo (00552267)

# of Collaborated Projects: 5 results

# of Collaborated Products: 18 results
4. 奥田勝博 (00389115)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 清水惠子 (90312462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. YAMAZAKI Takeshi (30192397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SKATA Shogo (50153888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ISHIDA Atsuhiko (90212886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MUKUDA Takao (60346335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHIHARA Yasuhiro (80435073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OGRA Yasumitsu (40292677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. FUJIMOTO Nariaki (40243612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MURATA Miho (30282643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KITAMURA Shigeyuki (40136057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. TOSHIHARA Shinnichi (00037607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KUZUHARA Shigeki (70111383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 酒井規雄 (70263407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 秀和泉 (20253073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 田中茂 (20512651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 河合秀彦 (30379846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 杉田誠 (50235884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 原田佳奈 (90609744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 宮良政嗣 (60816346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. URAMARU Naoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. HORIGUCHI Aya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. KANDA Yasunari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 出水庸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 細井徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 熊谷嘉人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kotake Yaichiro 古武 弥一郎

KOTAKE Yaichiro 古武 弥一郎

Research Projects

Research Products

Co-Researchers

Identification of novel ER stress relieving drugs using a high-content microscope and application to therapeutic developmentOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

危険ドラッグの新規化学構造と毒性・動態相関の解明およびヒトへの影響予測Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肝再生における臓器間連携による薬物動態変化と毒性発現を考慮した薬物治療戦略Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Risk of Parkinson's disease focused on the cause of diabetesPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure-toxicity relationship of designer drug having phenethylamine moietyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neurotoxicity of organotins via nuclear respiratory factor-1 (NRF-1) inhibitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cell response of glutamate transporter against rotenonePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation and model preparation of tropical area-specific endemic neurodegenerative diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Can tubulin be a novel target of toxicity of environmental chemicals ?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Organotin-induced GluR2 decrease and its in vivo neuronal effectsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Kotake Yaichiro 古武弥一郎

KOTAKE Yaichiro 古武弥一郎