HARADA Hironobu 原田広信

Researcher Number	20335897
Affiliation (based on the past Project Information) *help	2013: 愛媛大学, 医学部附属病院, 講師 2008: 愛媛大学, 医学部・附属病院, 講師 2006 – 2008: Ehime University, University Hospital, instructor, 医学部附属病院, 講師 2006: 愛媛大学, 医学部附属病院, 特任講師 2002 – 2005: 愛媛大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Cerebral neurosurgery / Neurosurgery Except Principal Investigator Cerebral neurosurgery / Cerebral neurosurgery
Keywords	Principal Investigator グリオーマ / VEGF / HIF-1α / in vivo 光イメージング / 血管新生阻害剤 / cancer stem cell / Oct-3/4 / HVJ-E vector / siRNA / Ku80 … More / Ku70 / アンチセンス / 腫瘍血管新生 / ラミニン-8 … More Except Principal Investigator siRNA / Ku70 / グリオーマ / 腫瘍浸潤 / HVJ-E vector / DNA repair / radiotherapy / glioma / DNA二本鎖切断 / HVJ-Eベクター / DNA修復 / 放射線治療 / ANTISENSE / LAMININ-8 / TUMOR INVASION / GLIOMA / アンチセンス / ラミニン-8 / 腫瘍発生 / マトリックスメタロプロテアーゼ / 腫瘍増殖 / 腫瘍幹細胞 / 悪性グリオーマ Less

In vivo 光イメージングを利用した膠芽腫幹細胞の破綻環境の探索Principal Investigator
- Principal Investigator
  
  原田広信
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Ehime University
Development of effective therapy for glioma invasion based on a glioma-derived tumor stem cell
- Principal Investigator
  
  OHNISHI Takanori
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Ehime University
悪性グリオーマにおけるDNA二重鎖切断修復遺伝子制御による新規放射線療法の開発Principal Investigator
- Principal Investigator
  
  原田広信
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Ehime University
Novel radiation therapy for malignant gliomas based on inhibition of DNA repair
- Principal Investigator
  
  OHNISHI Takanori
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Ehime University
悪性グリオーマにおけるラミニン-8アンチセンスによる腫瘍血管新生抑制に関する研究Principal Investigator
- Principal Investigator
  
  原田広信
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Ehime University
Establishment of a novel therapy for glioma invasion by antisense inhibition of the targeting molecule.
- Principal Investigator
  
  OHNISHI Takanori
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Ehime University

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Downregulation of SPARC expression inhibits cell migration and invasion in malignant gliomas.2009
- Author(s)
  Seno T, Harada H, Kohno S, Teraoka M, Inoue A, Ohnishi T
- Journal Title
  
  Int J Oncol 34
  
  Pages: 707-715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591683
[Journal Article] 脳浮腫2008
- Author(s)
  原田広信, 大西丘倫
- Journal Title
  
  Brain Nursing 24 (2)
  
  Pages: 23-25
- Data Source
  KAKENHI-PROJECT-19591683
[Journal Article] Silencing hypoxia-inducible factor-lalpha inhibits cell migration and invasion under hypoxic enviroment in malignant gliomas.2007
- Author(s)
  Fujiwara S, Nakagawa K, Harada H, et al.
- Journal Title
  
  Int J Oncol 30
  
  Pages: 793-802
- Data Source
  KAKENHI-PROJECT-17790974
[Journal Article] Silencing hypoxiainducible factor-1a inhibits cell migration and invasion under hypoxic environment in malignant gliomas2007
- Author(s)
  Fujiwara S, Nakagawa K, Harada H, Nagato S, Furukawa K, Teraoka M, Seno T, Oka K, Iwata S, Ohnishi T
- Journal Title
  
  Int J Oncol 30
  
  Pages: 793-802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591683
[Journal Article] PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules.2006
- Author(s)
  Furukawa K, Kumon Y, Harada H, et al.
- Journal Title
  
  Int J Oncol 29
  
  Pages: 73-81
- Data Source
  KAKENHI-PROJECT-17790974
[Journal Article] Down-regulation of laminin α 4 chain expression inhibits glioma invasion in vitro and in vivo2005
- Author(s)
  Nagato S, Nakagawa K, Harada H, et al.
- Journal Title
  
  Int J Cancer 117
  
  Pages: 41-50
- Data Source
  KAKENHI-PROJECT-17790974
[Journal Article] Midkine promoter-based conditionally replicative adenovirus for malignant Glioma therapy2004
- Author(s)
  Kohno S, Nakagawa K, Harada H, et al.
- Journal Title
  
  Oncol Rep 12
  
  Pages: 73-78
- Data Source
  KAKENHI-PROJECT-15790770
[Journal Article] Introduction of p16 inhibits telomerase activity through transcriptional Suppression of human telomerase reverse transcriptase expression in human gliomas2004
- Author(s)
  Saito M, Nakagawa K, Harada H, et al.
- Journal Title
  
  Int J Oncol 24
  
  Pages: 1213-1220
- Data Source
  KAKENHI-PROJECT-15790770
[Journal Article] Down-regulation of laminin α4 chain expression inhibits glioma invasion in vitro and in vivo
- Author(s)
  Nagato S, Nakagawa K, Harada H, et al.
- Journal Title
  
  Int J Cancer (In press)
- Data Source
  KAKENHI-PROJECT-15790770
[Journal Article] PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules
- Author(s)
  Furukawa K, Harada H, Ohnishi T, et al.
- Journal Title
  
  Int J Oncol (In press)
- Data Source
  KAKENHI-PROJECT-17790974
[Presentation] 中枢神経系悪性リンパ腫におけるHD-MTX時代の問題点2008
- Author(s)
  原田広信、大西丘倫、他
- Organizer
  第67回日本脳神経外科学会総会
- Place of Presentation
  岩手
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-19591683
[Presentation] 悪性グリオーマの浸潤におけるSPARCの役割2008
- Author(s)
  瀬野利太, 原田広信, 大西丘倫, 他
- Organizer
  第67回日本脳神経外科学会総会
- Place of Presentation
  岩手
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-19591683
[Presentation] 再発グリオーマにおけるSPARC 発現についての検討2007
- Author(s)
  原田広信、大西丘倫、他
- Organizer
  第25 回日本脳腫瘍学会
- Place of Presentation
  東京
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-19591683

1. OHNISHI Takanori (70233210)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. NAKAGAWA Kou (50155678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 井上明宏 (20593403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HARADA Hironobu 原田 広信

Research Projects

Research Products

Co-Researchers

In vivo 光イメージングを利用した膠芽腫幹細胞の破綻環境の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of effective therapy for glioma invasion based on a glioma-derived tumor stem cell

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

悪性グリオーマにおけるDNA二重鎖切断修復遺伝子制御による新規放射線療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel radiation therapy for malignant gliomas based on inhibition of DNA repair

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

悪性グリオーマにおけるラミニン-8アンチセンスによる腫瘍血管新生抑制に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of a novel therapy for glioma invasion by antisense inhibition of the targeting molecule.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Downregulation of SPARC expression inhibits cell migration and invasion in malignant gliomas.2009

Author(s)

Journal Title

Data Source

[Journal Article] 脳浮腫2008

Author(s)

Journal Title

Data Source

[Journal Article] Silencing hypoxia-inducible factor-lalpha inhibits cell migration and invasion under hypoxic enviroment in malignant gliomas.2007

Author(s)

Journal Title

Data Source

[Journal Article] Silencing hypoxiainducible factor-1a inhibits cell migration and invasion under hypoxic environment in malignant gliomas2007

Author(s)

Journal Title

Data Source

[Journal Article] PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules.2006

Author(s)

Journal Title

Data Source

[Journal Article] Down-regulation of laminin α 4 chain expression inhibits glioma invasion in vitro and in vivo2005

Author(s)

Journal Title

Data Source

[Journal Article] Midkine promoter-based conditionally replicative adenovirus for malignant Glioma therapy2004

Author(s)

Journal Title

Data Source

[Journal Article] Introduction of p16 inhibits telomerase activity through transcriptional Suppression of human telomerase reverse transcriptase expression in human gliomas2004

Author(s)

Journal Title

Data Source

[Journal Article] Down-regulation of laminin α4 chain expression inhibits glioma invasion in vitro and in vivo

Author(s)

Journal Title

Data Source

[Journal Article] PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules

Author(s)

Journal Title

Data Source

HARADA Hironobu 原田広信