YAMASHITA Hitoshi 山下均

Researcher Number	20342967
Other IDs
Affiliation (Current)	2025: 中部大学, 生命健康科学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 中部大学, 生命健康科学部, 教授 2012 – 2017: 中部大学, 生命健康科学部, 教授 2006: Chubu University, College of Life and Health Sciences, Professor, 生命健康科学部, 教授 2005: 国立長寿医療センター, (研究所)・老化制御研究部, 室長
Review Section/Research Field	Principal Investigator Applied molecular and cellular biology / Basic Section 59040:Nutrition science and health science-related / Basic Section 42030:Animal life science-related Except Principal Investigator Biophysics
Keywords	Principal Investigator CREG1 / 褐色脂肪 / UCP1 / 肥満 / 褐色脂肪細胞 / 糖尿病 / バトカイン / 熱産生細胞 / 骨格筋 / 筋分化 / Creg1 / 代謝性疾患 / エネルギー代謝 … More Except Principal Investigator … More cell death / uncoupling protein 2 / reactive oxygen species / bioimaging / biophysics / mitochondria / 神経細胞 / 酸化ストレス / 膜電位 / UCP2 / 細胞死 / 脱共役蛋白質UCP2 / 活性酸素 / バイオイメージング / 生物物理学 / ミトコンドリア Less

新規バトカインCREG1の糖代謝における役割と作用機序の解明Principal Investigator
- Principal Investigator
  
  山下均
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Chubu University
Role of CREG1 on the regulation of thermogenic cells and body temperaturePrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hitoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Chubu University
Physiological role of Creg1 on brown adipogenesisPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hitoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Chubu University
Study of the mechanism inducing brown adipocyte differentiationPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hitoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Chubu University
High accuracy function analysis of mitochondria with organelle adsorption method
- Principal Investigator
  
  OHTA Yoshihiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Tokyo University of Agriculture and Technology

All 2023 2022 2021 2020 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Patent

[Journal Article] The effect of Dunaliella tertiolecta supplementation on diet-induced obesity in UCP1-deficient mice.2023
- Author(s)
  Yamashita Y, Takeuchi T, Endo Y, Goto A, Uno M, Sakaki S, Yamaguchi Y, Takenaka H, Yamashita H.
- Journal Title
  
  Bioscience, Biotechnology ＆ Biochemistry.
  
  Volume: 88(1) Issue: 1 Pages: 16-25
- DOI
  10.1093/bbb/zbad138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K17668, KAKENHI-PROJECT-23K10881
[Journal Article] CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells2023
- Author(s)
  Goto A, Endo Y, Yamashita H.
- Journal Title
  
  Biochem Biophys Res Commun .
  
  Volume: 641 Pages: 162-167
- DOI
  10.1016/j.bbrc.2022.12.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K17668, KAKENHI-PROJECT-20K06450
[Journal Article] CREG1 improves diet‐induced obesity via uncoupling protein 1‐dependent manner in mice2022
- Author(s)
  Endo Yuki、Hashimoto Michihiro、Kusudo Tatsuya、Okada Tadashi、Takeuchi Tamaki、Goto Ayumi、Yamashita Hitoshi
- Journal Title
  
  Genes to Cells
  
  Volume: 27 Issue: 3 Pages: 202-213
- DOI
  10.1111/gtc.12920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06450, KAKENHI-PROJECT-21K17668
[Journal Article] 脂肪細胞をターゲットとした肥満・メタボの予防2022
- Author(s)
  山下均
- Journal Title
  
  Food STYLE 21
  
  Volume: 26 Pages: 49-51
- Data Source
  KAKENHI-PROJECT-20K06450
[Journal Article] CREG1 administration stimulates BAT thermogenesis and improves diet-induced obesity in mice2021
- Author(s)
  Kusudo Tatsuya、Okada Tadashi、Hashimoto Michihiro、Takeuchi Tamaki、Endo Yuki、Niwa Ayumi、Yamashita Hitoshi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 171 Issue: 1 Pages: 63-73
- DOI
  10.1093/jb/mvab106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06450
[Journal Article] Effects of CREG1 on age-associated metabolic phenotypes and renal senescence in mice2021
- Author(s)
  Hashimoto M, Goto A, Endo Y, Sugimoto M, Ueda J, and Yamashita H
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 22 Issue: 3 Pages: 1276-1276
- DOI
  10.3390/ijms22031276
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06450, KAKENHI-PROJECT-18K11034, KAKENHI-PROJECT-18K17934, KAKENHI-PROJECT-20H04116, KAKENHI-PROJECT-19K06452
[Journal Article] 脂肪組織特異的CREG1-Tgマウスを利用した老化研究2020
- Author(s)
  橋本理尋、上田潤、山下　均
- Journal Title
  
  細胞
  
  Volume: 52 Pages: 623-627
- NAID
  40022426640
- Data Source
  KAKENHI-PROJECT-20K06450
[Journal Article] Dietary Supplementation with Dunaliella Tertiolecta Prevents Whitening of Brown Fat and Controls Diet-Induced Obesity at Thermoneutrality in Mice2020
- Author(s)
  Yamashita Y, Takeuchi T, Endo Y, Goto A, Sakaki S, Yamaguchi Y, Takenaka H, Yamashita H
- Journal Title
  
  Nutrients
  
  Volume: 12 Issue: 6 Pages: 1686-1686
- DOI
  10.3390/nu12061686
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06450
[Journal Article] High temperature promotes amyloid β-protein production and γ-secretase complex formation via Hsp902020
- Author(s)
  Arshad Ali Noorani, Hitoshi Yamashita, Yuan Gao, Sadequl Islam, Yang Sun, Tomohisa Nakamura, Hiroyuki Enomoto, Kun Zou, Makoto Michikawa
- Journal Title
  
  J Biol Chem
  
  Volume: 295 Issue: 52 Pages: 18010-22
- DOI
  10.1074/jbc.ra120.013845
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07846, KAKENHI-PROJECT-20K06450, KAKENHI-PROJECT-20K07861
[Journal Article] Brown adipocytes suppress kidney stone formation via heat-producing protein, uncoupling protein 12020
- Author(s)
  Sugino T, Tanaka Y, Unno R, Taguchi K, Hamamoto S, Ando R, Okada A, Mogami T, Yamashita H, and Yasui T.
- Journal Title
  
  J. Urol.
  
  Volume: 203 (4S) Issue: Supplement 4
- DOI
  10.1097/ju.0000000000000824.09
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06450
[Journal Article] Silencing of FABP1 ameliorates hepatic steatosis, inflammation, and oxidative stress in mice with nonalcoholic fatty liver disease2017
- Author(s)
  Mukai Takako、Egawa Miki、Takeuchi Tamaki、Yamashita Hitoshi、Kusudo Tatsuya
- Journal Title
  
  FEBS Open Bio
  
  Volume: 7 Issue: 7 Pages: 1009-1016
- DOI
  10.1002/2211-5463.12240
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19938, KAKENHI-PROJECT-15K07846
[Journal Article] 脂肪組織特異的CREG1トランスジェニックマウスを利用した褐色脂肪化促進と生活習慣病改善の検討2016
- Author(s)
  橋本理尋、楠堂達也、竹内環、遠藤優貴、山下均
- Journal Title
  
  基礎老化研究
  
  Volume: 40 Pages: 35-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07846
[Patent] 褐色脂肪細胞分化誘導剤2013
- Inventor(s)
  山下　均、楠堂達也
- Industrial Property Rights Holder
  中部大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013
- Overseas
- Data Source
  KAKENHI-PROJECT-24580499
[Patent] 褐色脂肪細胞分化誘導剤2012
- Inventor(s)
  山下　均、楠堂達也
- Industrial Property Rights Holder
  中部大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-180905
- Filing Date
  2012
- Data Source
  KAKENHI-PROJECT-24580499
[Presentation] CREG1が骨格筋再生過程に及ぼす影響2023
- Author(s)
  後藤亜由美、西本蒼、星谷龍、遠藤優貴、山下　均
- Organizer
  第46回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-23K10881
[Presentation] CREG1 enhances glucose uptake via AMPK in C2C12 myotube2022
- Author(s)
  GOTO Ayumi, ENDO Yuki, HASHIMOTO Michihiro, UNO Misa, YAMASHITA Hitoshi
- Organizer
  第45回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-20K06450
[Presentation] CREG1が骨格筋糖代謝に及ぼす影響2022
- Author(s)
  後藤亜由美、遠藤優貴、宇野未沙、山下均
- Organizer
  第77回日本体力医学会
- Data Source
  KAKENHI-PROJECT-20K06450
[Presentation] 糖尿病モデルマウスにおけるCREG1の病態生理学的役割の検討2022
- Author(s)
  宇野未紗、杉原由佳、惠木沙織、所綾香、後藤亜由美、遠藤優貴、橋本理尋、山下均
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K06450
[Presentation] UCP1はCREG1の抗肥満作用に不可欠である2021
- Author(s)
  遠藤優貴, 橋本理尋, 楠堂達也, 岡田只士, 後藤亜由美, 宇野未紗, 山下均
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K06450
[Presentation] CREG1 enhances muscle function in mice2021
- Author(s)
  GOTO Ayumi, HASHIMOTO Michihiro, YOKOGAWA Sho, ENDO Yuki, MARUYAMA Mitsuo, YAMASHITA Hitoshi
- Organizer
  第44回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-20K06450
[Presentation] The effect of CREG1 for energy metabolism in aged mice2020
- Author(s)
  Ayumi Goto, Yuki Endo, Michihiro Hashimoto, Hitoshi Yamashita
- Organizer
  第43回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-20K06450
[Presentation] 絶食下におけるCREG1の生理的役割の検討2020
- Author(s)
  遠藤優貴, 後藤亜由美, 松井美佳, 山下均
- Organizer
  第43回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K06450
[Presentation] Higher core body temperature exacerbates the pathologies of Alzheimer's disease2020
- Author(s)
  Jung CG, Yamashita H, Michikawa M
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-20K06450
[Presentation] CREG1が高齢マウスの脂質代謝に及ぼす影響2020
- Author(s)
  後藤亜由美、橋本理尋、遠藤優貴、山下　均
- Organizer
  第75回日本体力医学会
- Data Source
  KAKENHI-PROJECT-20K06450
[Presentation] Study of pathophysiological role of CREG1 protein using aP2-CREG1 transgenic mice.2017
- Author(s)
  HASHIMOTO M, KUSUDO T, TAKEUCHI T, OHMI Y, YAMASHITA H
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-15K07846
[Presentation] 白色脂肪組織の褐色脂肪化におけるCREG1の役割2017
- Author(s)
  楠堂達也，橋本理尋，竹内環，片岡直也，山下均
- Organizer
  平成28年度温熱生理研究会
- Data Source
  KAKENHI-PROJECT-15K07846
[Presentation] 脂肪酸結合タンパク質の発現抑制が非アルコール性肝疾患の改善に及ぼす効果2017
- Author(s)
  向丼貴子、江川美貴、山下均、楠堂達也
- Organizer
  第40回日本分子生物学会・第90回日本生化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-15K07846
[Presentation] 生体内におけるCREG1の褐色脂肪化促進作用の検討2017
- Author(s)
  橋本理尋、楠堂達也、竹内環、山下均
- Organizer
  第40回日本分子生物学会・第90回日本生化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-15K07846
[Presentation] RNA結合タンパク質KHDRBS3が褐色脂肪分化に及ぼす影響2017
- Author(s)
  楠堂達也、片岡直也、山下均
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-15K07846
[Presentation] 褐色脂肪細胞分化における転写後調節の関り2017
- Author(s)
  楠堂達也、宮越あみ、山口奈津絵、向丼貴子、片岡直也、山下均
- Organizer
  第40回日本分子生物学会・第90回日本生化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-15K07846
[Presentation] CREG1の抗肥満作用に対する環境温度の影響について2016
- Author(s)
  遠藤優貴、橋本理尋、竹内環、楠堂達也、岡田只士、山下均
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K07846
[Presentation] 脂肪組織特異的CREG1-Tgマウスによる褐色脂肪化と生活習慣病改善の検討2016
- Author(s)
  橋本理尋、楠堂達也、竹内環、遠藤優貴、山下均
- Organizer
  第39回日本基礎老化学会大会
- Place of Presentation
  伊勢原市民文化会館（神奈川県・伊勢原市）
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-15K07846
[Presentation] 分泌型糖タンパク質CREG1の褐色脂肪化作用2015
- Author(s)
  楠堂達也、遠藤優貴、片岡直也、橋本理尋、岡田只士、山下均
- Organizer
  第20回アディポサイエンス・シンポジウム
- Place of Presentation
  千里ライフサイエンスセンター（大坂府・豊中市）
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-15K07846
[Presentation] 個体レベルにおける分泌型糖タンパク質CREG1の作用2015
- Author(s)
  岡田只士、楠堂達也、竹内環、遠藤優貴、橋本理尋、西沢祐治、山下均
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K07846
[Presentation] 褐色脂肪化における分泌糖タンパク質CREG1の作用の検討2015
- Author(s)
  楠堂達也、片岡直也、橋本理尋、岡田只士、山下均
- Organizer
  第36回日本肥満学会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K07846
[Presentation] 分泌型糖タンパク質CREG1による褐色脂肪化作用の解析2014
- Author(s)
  楠堂達也、片岡直也、野崎絢、山下均
- Organizer
  第35回日本肥満学会
- Place of Presentation
  宮崎シーガイアコンベンションセンター
- Year and Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-24580499
[Presentation] 分泌型糖タンパク質CREG1は褐色脂肪細胞の分化を促進する2014
- Author(s)
  野崎絢、楠堂達也、竹内環、山下均
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-24580499
[Presentation] UCP1/ApoEダブルノックアウトマウスにおける皮下白色脂肪の褐色脂肪化に関連する遺伝子の解析．
- Author(s)
  李　勇学、楠堂達也、片岡直也、山下均
- Organizer
  第33回日本肥満学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24580499
[Presentation] CREG1による褐色脂肪化作用の検討
- Author(s)
  楠堂達也、片岡直也、野崎絢、山下　均
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24580499
[Presentation] Cellular Repressor of E1A-stimulated genes 1 is a novel regulator of brown adipocyte differentiation
- Author(s)
  Kusudo, T., Kataoka, N., Takeuchi, T., Nozaki, A. and Yamashita, H.
- Organizer
  12th International Congress on Obesity (ICO2014)
- Place of Presentation
  Kuala Lumpur (Malaysia)
- Data Source
  KAKENHI-PROJECT-24580499
[Presentation] リコンビナントCREG1による褐色脂肪分化作用の検討
- Author(s)
  楠堂達也、李勇学、片岡直也、江川美貴、山下均
- Organizer
  日本農芸化学会2012大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24580499

1. KUSUDO Tatsuya (00460535)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
2. 竹内環 (90392018)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. OHTA Yoshihiro (10223843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 後藤亜由美 (20780969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
5. KATAOKA Naoya

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. LI Yongxue

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. KOJIMA Motoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NOZAKI Aya

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. HASHIMOTO Michihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
10. OKADA Tadashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. ENDO Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. ZOU Kun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 向井貴子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMASHITA Hitoshi 山下 均

Research Projects

Research Products

Co-Researchers

新規バトカインCREG1の糖代謝における役割と作用機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of CREG1 on the regulation of thermogenic cells and body temperaturePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Physiological role of Creg1 on brown adipogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of the mechanism inducing brown adipocyte differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

High accuracy function analysis of mitochondria with organelle adsorption method

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The effect of Dunaliella tertiolecta supplementation on diet-induced obesity in UCP1-deficient mice.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CREG1 improves diet‐induced obesity via uncoupling protein 1‐dependent manner in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 脂肪細胞をターゲットとした肥満・メタボの予防2022

Author(s)

Journal Title

Data Source

[Journal Article] CREG1 administration stimulates BAT thermogenesis and improves diet-induced obesity in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of CREG1 on age-associated metabolic phenotypes and renal senescence in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 脂肪組織特異的CREG1-Tgマウスを利用した老化研究2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Dietary Supplementation with Dunaliella Tertiolecta Prevents Whitening of Brown Fat and Controls Diet-Induced Obesity at Thermoneutrality in Mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High temperature promotes amyloid β-protein production and γ-secretase complex formation via Hsp902020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Brown adipocytes suppress kidney stone formation via heat-producing protein, uncoupling protein 12020

Author(s)

YAMASHITA Hitoshi 山下均